CN114068131A - A transcranial magnetic stimulation coil - Google Patents
A transcranial magnetic stimulation coil Download PDFInfo
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- CN114068131A CN114068131A CN202111386520.7A CN202111386520A CN114068131A CN 114068131 A CN114068131 A CN 114068131A CN 202111386520 A CN202111386520 A CN 202111386520A CN 114068131 A CN114068131 A CN 114068131A
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- 238000011491 transcranial magnetic stimulation Methods 0.000 title claims abstract description 39
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F5/00—Coils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F27/00—Details of transformers or inductances, in general
- H01F27/02—Casings
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F27/00—Details of transformers or inductances, in general
- H01F27/02—Casings
- H01F27/022—Encapsulation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F27/00—Details of transformers or inductances, in general
- H01F27/24—Magnetic cores
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F27/00—Details of transformers or inductances, in general
- H01F27/28—Coils; Windings; Conductive connections
- H01F27/30—Fastening or clamping coils, windings, or parts thereof together; Fastening or mounting coils or windings on core, casing, or other support
- H01F27/306—Fastening or mounting coils or windings on core, casing or other support
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Abstract
本发明提供了一种经颅磁刺激线圈，涉及经颅磁刺激技术领域，包括由内向外依次设置的定位壳，线圈以及主壳体，所述定位壳包括呈倒锥状的侧壳以及与侧壳一体成型的定位柱，所述定位柱位于侧壳的底部且沿侧壳的轴线方向内凹，所述线圈均匀的缠设在侧壳的外表面且线圈的中心轴与主壳体的中心轴相对应，所述定位柱内插设有铁芯，所述主壳体包括底座，侧壁以及位于侧壁顶部的上盖，所述上盖的顶面设有线圈接口。本发明通过将线圈设计成圆锥形的结构并增加铁芯材料，显著增加了线圈的聚焦性，还可以增大刺激强度，本发明适用于针对大鼠等小动物的经颅磁刺激实验研究。
The invention provides a transcranial magnetic stimulation coil, which relates to the technical field of transcranial magnetic stimulation. The positioning column is integrally formed with the side shell. The positioning column is located at the bottom of the side shell and is concave in the axial direction of the side shell. Corresponding to the central axis, an iron core is inserted into the positioning column, the main casing includes a base, a side wall and an upper cover located on the top of the side wall, and the top surface of the upper cover is provided with a coil interface. By designing the coil into a conical structure and increasing the iron core material, the present invention significantly increases the focusability of the coil and can also increase the stimulation intensity. The present invention is suitable for experimental research on transcranial magnetic stimulation of small animals such as rats.
Description
Technical Field
The invention relates to the technical field of transcranial magnetic stimulation, in particular to a transcranial magnetic stimulation coil for improving the focality of transcranial magnetic stimulation.
Background
Transcranial magnetic stimulation is a non-invasive and painless biological stimulation technology, and the principle is Faraday electromagnetic induction, and utilizes a variable magnetic field to generate an induction electric field in a cerebral cortex to stimulate neuron cells, so as to generate a series of physiological reactions and achieve the purpose of treating diseases. The technology is widely used for treating diseases such as depression, insomnia, Parkinson's disease, Alzheimer's disease, epilepsy, schizophrenia and the like, has potential clinical treatment value, and becomes an effective examination and treatment means in the biomedical research field and the neurological medicine research field. The magnetic stimulation coil is used as the output end of the whole device and is an important component of the skull magnetic stimulation instrument, and the energy output by the coil directly acts on the focal zone of a patient. Induced electric field distributions generated by different coil shapes can be different, and the action effect can be greatly different. The structure of the coil was studied by many researchers afterwards to improve the stimulation effect, and mainly human coils were studied, such as a circular coil, a figure-8 coil, a Slink coil, a biconical coil, a coil with a shield plate, a coil with a ferrite core, and so on.
Two important indexes for measuring the performance of the transcranial magnetic stimulation coil are focusing performance and stimulation intensity, wherein the focusing performance refers to the size of a focusing area of the effect of the coil at a target point of the head of a patient, under the condition of certain stimulation intensity, the smaller the focusing area is, the higher the focusing performance is, the stimulation intensity is usually represented by induction electric field intensity, and the larger the stimulation intensity is, the more the tissue structure in the deep part of the brain of the patient can be stimulated, and the more the treatment effect can be achieved. Transcranial magnetic stimulation has good potential in regulating human brain plasticity, but the mechanism of cells and molecules for inducing plasticity is still unclear, and the animal model plays an important role in understanding the potential mechanism of transcranial magnetic stimulation. The present animal model experiment research is mainly performed on rats, and one of the main limitations is the lack of specific magnetic stimulation coils for rats, if a typical human stimulation coil with a radius of 30mm is applied to the brain of rats, the whole brain of rats is stimulated, but only a more concentrated region on the human brain is stimulated, so that it is necessary to develop a magnetic stimulation coil for rats, which has high focusing property and can maintain high stimulation intensity.
Disclosure of Invention
The invention aims to solve the technical problem of overcoming the defects in the prior art and provides a transcranial magnetic stimulation coil for improving the focality of transcranial magnetic stimulation.
The invention is realized by the following technical scheme: a transcranial magnetic stimulation coil is characterized by comprising a positioning shell, a coil and a main shell, wherein the positioning shell, the coil and the main shell are sequentially arranged from inside to outside, the positioning shell comprises a side shell in an inverted cone shape and a positioning column integrally formed with the side shell, the positioning column is located at the bottom of the side shell and is recessed along the axis direction of the side shell, the coil is uniformly wound on the outer surface of the side shell, the central axis of the coil corresponds to the central axis of the main shell, an iron core is inserted into the positioning column, the main shell comprises a base, a side wall and an upper cover located at the top of the side wall, and a coil interface is arranged on the top surface of the upper cover.
According to the technical scheme, preferably, the coil is uniformly wound on the side shell of the positioning shell in a spiral ascending mode, the overall shape of the coil is conical, the outer diameter of the bottom surface is 10mm, the outer diameter of the top surface is 60-90 mm, and the height is 100-150 mm.
According to the technical scheme, preferably, the side wall, the upper cover and the side shell are provided with ventilation openings.
According to the above technical solution, preferably, the surface of the coil is wrapped with an epoxy resin cured layer.
According to the above technical solution, preferably, the iron core is a cylindrical soft magnetic ferrite with a diameter of 4mm and a height equal to the height of the coil.
According to the above technical solution, preferably, the base, the side wall and the upper cover of the main housing are connected in a split manner.
According to the technical scheme, preferably, the main shell and the positioning shell are both made of high-temperature-resistant materials.
According to the technical scheme, preferably, the side shell is of an open structure with an unsealed top, and the height of the positioning column is 20-50 mm.
The invention has the beneficial effects that: (1) the invention adopts the coil with the conical structure, when in use, the base of the main shell is directly contacted with the target point of the rat head, and the central axis of the coil is vertically arranged with the target point. The classical circular coil is vertically placed on the organism tissue to generate an induction electric field which is distributed in a circular ring shape, the edge of the circular ring can reach the maximum induction electric field, the coil with a large radius can generate a larger induction electric field at the head of a rat, but the focusing performance is poor, and the coil with a small radius can generate a smaller induction electric field, but the focusing performance is good. The radius below the coil is only 5mm, and the part of the coil directly acting on the target point is below the coil, so that the acting area of the transcranial magnetic stimulation coil is limited within a small range, the stimulation area is obviously reduced, and the focusing performance of the coil is improved. In order to make up for the insufficient stimulation intensity caused by the smaller radius of the lower coil, the coil adopts a spiral ascending winding mode, and the magnetic field is increased by increasing the number of turns of the coil, so that the induced electric field intensity at a target point is improved, the stimulation intensity at the target point is increased, in addition, the radius of the upper coil is gradually increased, the coil with the larger radius can generate a larger induced electric field at the head of a rat, and the transcranial magnetic stimulation coil provided by the invention is ensured to have higher focusing performance and larger stimulation intensity.
(2) The invention adds an iron core structure, the iron core can adopt manganese zinc ferrite with high magnetic conductivity, so that most of magnetic field in the air around the coil passes through the iron core, the dispersion of the magnetic field is reduced, the diameter of the iron core is only 4mm, the use of the iron core not only increases the focusing property of the coil but also increases the magnetic field intensity, and the iron core and the coil are superposed to realize high-focusing high-intensity stimulation.
(3) According to the invention, the positioning shell structure is added, the side shell of the positioning shell is an arc-shaped surface, the coil is spirally and uniformly wound on the side shell, and epoxy resin is wrapped on the outer surface of the coil, so that the positioning effect is increased, and the coil is prevented from moving in the shell.
Drawings
FIG. 1 shows a schematic structural diagram of an embodiment of the present invention;
FIG. 2 shows a block diagram of a coil in accordance with an embodiment of the present invention;
fig. 3 shows a structural view of a core in an embodiment of the present invention;
FIG. 4 shows a block diagram of a main housing of an embodiment of the invention;
fig. 5 shows a block diagram of a positioning housing according to an embodiment of the invention.
In the figure: 1. a positioning shell; 11. a side casing; 12. a positioning column; 2. a coil; 3. a main housing; 31. a base; 32. a side wall; 33. an upper cover; 34. a coil interface; 4. an iron core; 5. and a vent.
Detailed Description
In order to make the technical solutions of the present invention better understood by those skilled in the art, the present invention will be further described in detail with reference to the accompanying drawings and preferred embodiments.
As shown in the figures, the transcranial magnetic stimulation coil is characterized by comprising a positioning shell 1, a coil 2 and a main shell 3 which are sequentially arranged from inside to outside, wherein the positioning shell 1 comprises a side shell 11 in an inverted cone shape and a positioning column 12 integrally formed with the side shell 11, the positioning column 12 is located at the bottom of the side shell 11 and is recessed along the axis direction of the side shell 11, the coil 2 is uniformly wound on the outer surface of the side shell 11, the central axis of the coil 2 corresponds to the central axis of the main shell 3, an iron core 4 is inserted into the positioning column 12, the main shell 3 comprises a base 31, a side wall 32 and an upper cover 33 located at the top of the side wall 32, and a coil interface 34 is arranged on the top surface of the upper cover 33.
The working principle of the invention is as follows: the coil is wound on the shell of the positioning shell, the surface of the coil is wrapped by the epoxy resin curing layer, the iron core is placed into the positioning column, and finally the coil, the iron core and the positioning shell are placed into the main shell together, so that the central axis of the coil corresponds to the central axis of the main shell. When the magnetic stimulation device is used, the base of the main shell is in direct contact with a target point of the head of a rat, the central axis of the coil is perpendicular to the target point, and the coil interface can facilitate the control system to supply power to the transcranial magnetic stimulation coil aiming at the rat.
The classical circular coil is vertically placed on the organism tissue to generate an induction electric field which is distributed in a circular ring shape, the edge of the circular ring can reach the maximum induction electric field, the coil with a large radius can generate a larger induction electric field at the head of a rat, but the focusing performance is poor, and the coil with a small radius can generate a smaller induction electric field, but the focusing performance is good.
Because the radius below the coil is smaller, and the part of the coil directly acting on the target point is below the coil, the action area of the transcranial magnetic stimulation coil is limited within a small range, the stimulation area is obviously reduced, and the focusing performance of the coil is improved. In order to make up for the insufficient stimulation intensity caused by the smaller radius of the lower coil, the coil adopts a spiral ascending winding mode, and the magnetic field is increased by increasing the number of turns of the coil, so that the induced electric field intensity at a target point is improved, the stimulation intensity at the target point is increased, in addition, the radius of the upper coil is gradually increased, the coil with the larger radius can generate a larger induced electric field at the head of a rat, and the transcranial magnetic stimulation coil provided by the invention is ensured to have higher focusing performance and larger stimulation intensity.
According to the above embodiment, preferably, the coil is uniformly wound on the side casing of the positioning shell in a spiral rising manner, the overall shape of the coil is conical, the outer diameter of the bottom surface is 10mm, the outer diameter of the top surface is 60-90 mm, and the height is 100-150 mm, the radius of the upper part of the coil is gradually increased, and the coil with larger radius can generate larger induced electric field on the head of the rat, so that larger stimulation intensity is ensured. This both increases the focality to the target site and increases the stimulation intensity of the transcranial magnetic stimulation coil for the rat.
According to the above embodiment, it is preferable that the side walls, the upper cover, and the side cases are provided with the ventilation openings 5.
According to the embodiment, the surface of the coil is wrapped with the epoxy resin curing layer, so that the degree of freedom of the coil in the shell is limited, the positioning effect is increased, the coil is prevented from moving in the shell, and the practicability of the transcranial magnetic stimulation coil for rats is improved.
According to the above embodiment, preferably, the iron core is a cylindrical soft magnetic ferrite, the diameter is 4mm, and the height is the same as the height of the coil, so that most of the magnetic field in the air around the coil passes through the iron core, the dispersion of the magnetic field is reduced, the diameter of the iron core is only 4mm, the use of the iron core increases the focusing property and the magnetic field strength of the coil, and the iron core is superposed with the action of the coil, so that high-focusing high-strength stimulation is realized, the focusing property of the transcranial magnetic stimulation coil for rats on a target point is further improved, and the stimulation strength of the transcranial magnetic stimulation coil for rats is also improved.
According to the above embodiment, preferably, the base, the side wall and the upper cover of the main housing are connected in a split manner.
According to the embodiment, preferably, the main shell and the positioning shell are made of high-temperature-resistant materials, the coil and the iron core can generate a large amount of heat due to long-time work, the main shell and the positioning shell have high temperature resistance and mechanical strength, the main shell is arranged to protect the coil and the iron core, and the durability of the transcranial magnetic stimulation coil for rats is improved.
According to the embodiment, the side shell is preferably of an open structure with an unsealed top, the height of the positioning column is 20-50 mm, the positioning column is convenient to place the iron core, the iron core is prevented from shaking inside the coil when the transcranial magnetic stimulation coil for rats is used, and the practicability of the transcranial magnetic stimulation coil for rats is improved.
The arrangement of the ventilation opening enables the cooling structure to be simple and easy to process and manufacture. The positioning shell is not closed, the positioning column is low in height, heat dissipation of the iron core is facilitated, and the structures are beneficial to cooling of the coil, so that the coil can work for a long time.
For a circular coil, when the central axis of the coil is vertical to a target point, the generated induction electric field is in a circular ring shape, a larger induction electric field is generated at the edge of the circular ring, when the coil is slightly inclined at a certain angle, the distribution of the induction electric field in a focus area can be changed, so that the electric field distribution has asymmetry, the larger induction electric field is intensively distributed at the position contacted with the target point, therefore, the coil can be inclined by 5-10 degrees during use, which is beneficial to positioning a certain focus area of a rat for targeted treatment, the focusing property of the coil on the head of the rat is increased, and the stimulation of non-target cells is reduced. Further increasing the focusability of the transcranial magnetic stimulation coil for rats with respect to the target site.
The invention has the beneficial effects that: (1) the invention adopts the coil with the conical structure, when in use, the base of the main shell is directly contacted with the target point of the rat head, and the central axis of the coil is vertically arranged with the target point. The classical circular coil is vertically placed on the organism tissue to generate an induction electric field which is distributed in a circular ring shape, the edge of the circular ring can reach the maximum induction electric field, the coil with a large radius can generate a larger induction electric field at the head of a rat, but the focusing performance is poor, and the coil with a small radius can generate a smaller induction electric field, but the focusing performance is good. The radius below the coil is only 5mm, and the part of the coil directly acting on the target point is below the coil, so that the acting area of the transcranial magnetic stimulation coil is limited within a small range, the stimulation area is obviously reduced, and the focusing performance of the coil is improved. In order to make up for the insufficient stimulation intensity caused by the smaller radius of the lower coil, the coil adopts a spiral ascending winding mode, and the magnetic field is increased by increasing the number of turns of the coil, so that the induced electric field intensity at a target point is improved, the stimulation intensity at the target point is increased, in addition, the radius of the upper coil is gradually increased, the coil with the larger radius can generate a larger induced electric field at the head of a rat, and the transcranial magnetic stimulation coil provided by the invention is ensured to have higher focusing performance and larger stimulation intensity.
(2) The invention adds an iron core structure, the iron core can adopt manganese zinc ferrite with high magnetic conductivity, so that most of magnetic field in the air around the coil passes through the iron core, the dispersion of the magnetic field is reduced, the diameter of the iron core is only 4mm, the use of the iron core not only increases the focusing property of the coil but also increases the magnetic field intensity, and the iron core and the coil are superposed to realize high-focusing high-intensity stimulation.
(3) According to the invention, the positioning shell structure is added, the side shell of the positioning shell is an arc-shaped surface, the coil is spirally and uniformly wound on the side shell, and epoxy resin is wrapped on the outer surface of the coil, so that the positioning effect is increased, and the coil is prevented from moving in the shell.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (8)
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| CN202111386520.7A CN114068131A (en) | 2021-11-22 | 2021-11-22 | A transcranial magnetic stimulation coil |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114712717A (en) * | 2022-04-13 | 2022-07-08 | 北京脑陆科技有限公司 | Transcranial magnetic stimulation system and method |
| CN120771455A (en) * | 2025-09-09 | 2025-10-14 | 佛山玉玄宫科技股份有限公司 | Multi-point dense fine magnetic therapy device |
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