CN114062036B - Blood sample distribution method, blood detection device, and computer-readable storage medium - Google Patents
Blood sample distribution method, blood detection device, and computer-readable storage medium Download PDFInfo
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- CN114062036B CN114062036B CN202010761455.0A CN202010761455A CN114062036B CN 114062036 B CN114062036 B CN 114062036B CN 202010761455 A CN202010761455 A CN 202010761455A CN 114062036 B CN114062036 B CN 114062036B
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- 210000004369 blood Anatomy 0.000 title claims abstract description 288
- 239000008280 blood Substances 0.000 title claims abstract description 288
- 238000001514 detection method Methods 0.000 title claims abstract description 268
- 238000000034 method Methods 0.000 title claims abstract description 65
- 238000005070 sampling Methods 0.000 claims abstract description 218
- 238000000926 separation method Methods 0.000 claims abstract description 58
- 238000012360 testing method Methods 0.000 claims description 44
- 238000004140 cleaning Methods 0.000 claims description 37
- 239000007788 liquid Substances 0.000 claims description 35
- 238000002156 mixing Methods 0.000 claims description 14
- 239000012530 fluid Substances 0.000 claims description 8
- 230000036039 immunity Effects 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims 5
- 239000000523 sample Substances 0.000 description 161
- 210000004027 cell Anatomy 0.000 description 116
- 210000000265 leukocyte Anatomy 0.000 description 83
- 239000003085 diluting agent Substances 0.000 description 22
- 210000003743 erythrocyte Anatomy 0.000 description 22
- 238000006073 displacement reaction Methods 0.000 description 16
- 238000009534 blood test Methods 0.000 description 14
- 210000000601 blood cell Anatomy 0.000 description 12
- 238000010586 diagram Methods 0.000 description 8
- 238000012864 cross contamination Methods 0.000 description 7
- 238000004062 sedimentation Methods 0.000 description 7
- 238000003018 immunoassay Methods 0.000 description 4
- 239000002699 waste material Substances 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000009666 routine test Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1445—Overpressure, pressurisation at sampling point
- G01N2001/1463—Injector; Air-lift
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- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Hydrology & Water Resources (AREA)
- Investigating Or Analysing Biological Materials (AREA)
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Abstract
The application relates to the technical field of medical treatment, and discloses a blood sample distribution method, a blood detection device and a computer readable storage medium. The blood sample distribution method comprises the following steps: controlling a sampling needle to suck a blood sample to be detected; controlling sampling to perform blood separation operation on the WBC detection pond; and controlling sampling to perform blood separation operation on the rest detection pools, wherein the rest detection pools at least comprise immune detection pools. By the mode, the accuracy of blood sample detection can be improved.
Description
Technical Field
The present invention relates to the field of medical technology, and in particular, to a blood sample distribution method, a blood detection device, and a computer readable storage medium.
Background
In order to increase the speed, the current blood detection device firstly divides blood in an immune detection cell and then runs to a blood routine detection cell, so that when the user selects or does not select immune channels or the number of the selected immune channels is not constant, the volume of the sucked blood sample is not determined, and the position of the blood sample which is divided to the blood routine is also not determined.
The method has the defects that on one hand, the volume of the blood sample sucked by the sampling needle is also uncertain due to the uncertainty of the quantity of the blood sample detection items, so that the volume of the blood sample which is divided into a blood conventional detection pool each time has larger deviation, and the accuracy of blood sample detection is affected; on the other hand, the number of the immune detection cells used for detection also affects the time that the blood sample stays in the sampling needle, and the more the number of the immune detection cells used for detection is, the longer the time that the blood sample stays in the sampling needle is, when the blood sample is separated into the blood conventional detection cells, the number of blood cells contained in the blood sample is less, and the accuracy of blood sample detection is affected.
Disclosure of Invention
The technical problem that this application mainly solves is to provide blood sample distribution method, blood detection device and computer-readable storage medium, can improve blood sample detection's accuracy.
The technical scheme adopted by the application is to provide a blood sample distribution method, which comprises the following steps: controlling a sampling needle to suck a blood sample to be detected; controlling sampling to perform blood separation operation on the WBC detection pond; and controlling sampling to perform blood separation operation on the rest detection pools, wherein the rest detection pools at least comprise immune detection pools.
Wherein, control sampling is to remaining detection pond carry out blood separation operation, include: performing blood separation operation on at least one immune detection cell according to a preset sequence; performing blood separation operation on the DIFF detection cell; and (5) performing blood separation operation on the RBC detection pool.
Wherein the method further comprises: in the process of blood sample distribution of at least one immune detection cell, the liquid in the WBC detection cell is uniformly mixed.
Wherein, in the process of carrying out blood sample distribution to at least one immune detection cell, carry out the operation of mixing to the liquid in the WBC detection cell, include: in the course of blood sample distribution for each immunodetection cell, the liquid in the WBC detection cell is subjected to a single homogenization operation.
Wherein, carry out blood separation operation to at least one immunodetection pond according to predetermineeing the order, include: controlling the sampling needle and the swab component to move to a target immune detection pool; controlling the sampling needle to throw blood in the swab assembly; controlling the sampling needle to move downwards, and distributing a preset volume of blood sample to be detected to a target immune detection pool; and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the upward movement process.
Wherein, carry out blood separation operation to DIFF detection cell, include: controlling the sampling needle and the swab assembly to move to the DIFF detection cell; controlling the sampling needle to throw blood in the swab assembly; controlling the sampling needle to move downwards and distributing a preset volume of blood sample to be detected to a DIFF detection pool; and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the upward movement process.
Wherein, before carrying out blood separation operation to RBC detection pond, include: controlling the sampling needle and the swab assembly to move to the WBC detection cell; controlling the sampling needle to throw blood in the swab component, and cleaning the inner wall of the sampling needle; controlling the sampling needle to move downwards into the WBC detection cell and sucking part of liquid from the WBC detection cell; and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the upward movement process.
Wherein, carry out blood separation operation to RBC detection pond, include: controlling the sampling needle and the swab component to move to the RBC detection pool; controlling the sampling needle to throw blood in the swab assembly; controlling the sampling needle to move downwards and distributing part of liquid in the sampling needle to the RBC detection pool; and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the upward movement process.
Another technical scheme adopted by the application is to provide a blood detection device, which comprises a processor and a memory connected with the processor; the memory is used for storing program data, and the processor is used for executing the program data to realize the method provided by the technical scheme.
Another technical solution adopted in the present application is to provide a computer readable storage medium for storing program data, which when executed by a processor, is configured to implement the method provided in the above technical solution.
The beneficial effects of this application are: in contrast to the prior art, a blood sample dispensing method of the present application comprises: controlling a sampling needle to suck a blood sample to be detected; controlling sampling to perform blood separation operation on the WBC detection pond; and controlling sampling to perform blood separation operation on the rest detection pools, wherein the rest detection pools at least comprise immune detection pools. Through the mode, compared with the prior art, on one hand, the volume of the blood sample to be detected, which is distributed to the WBC detection pond, is determined due to the fact that the WBC detection pond is subjected to blood separation operation preferentially, the residence time of the blood sample to be detected, which is distributed to the WBC detection pond, in the sampling needle is reduced, the problem of blood cell sedimentation in the blood sample to be detected in the sampling needle is solved, the number of blood cells in the blood sample to be detected, which is distributed to the WBC detection pond, can be guaranteed, the accuracy of blood sample detection is improved, on the other hand, the joint progress of a plurality of detection items can be realized, and the detection efficiency is improved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art. Wherein:
FIG. 1 is a schematic view of an embodiment of a blood test apparatus provided herein;
FIG. 2 is a schematic flow chart of a first embodiment of a blood sample dispensing method provided herein;
FIG. 3 is a schematic diagram of an application field Jing Liucheng of the blood sample dispensing method provided herein;
FIG. 4 is a schematic flow chart of a second embodiment of a blood sample dispensing method provided herein;
FIG. 5 is a schematic diagram of the specific flow of step 408 in FIG. 4 provided herein;
FIG. 6 is a schematic diagram of a specific flow chart of step 409 in FIG. 4 provided herein;
FIG. 7 is a schematic diagram of a specific flow chart of step 410 in FIG. 4 provided herein;
FIG. 8 is a schematic view of a structure of a sampling needle according to the present disclosure after sucking a sample;
FIG. 9 is a schematic view of another structure of the sampling needle provided in the present application after aspiration;
FIG. 10 is a schematic view of another embodiment of a blood test apparatus provided herein;
fig. 11 is a schematic structural diagram of an embodiment of a computer readable storage medium provided in the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the specific embodiments described herein are for purposes of illustration only and are not limiting. It should be further noted that, for convenience of description, only some, but not all of the structures related to the present application are shown in the drawings. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the present application. The appearances of such phrases in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those of skill in the art will explicitly and implicitly appreciate that the embodiments described herein may be combined with other embodiments.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a blood test apparatus provided in the present application. The blood testing device 10 includes a sample-aspirating assembly 11, a blood routine testing well 12, an immunoassay well 13, a washing assembly 14, and a drive assembly 15.
The blood routine test cell 12 includes at least a WBC (white blood cell) test cell, a RBC (red blood cell) test cell, and a DIFF (differential) test cell.
Wherein the immunodetection cell 14 comprises at least one immunodetection cell, as shown in FIG. 1, the immunodetection cell 14 comprises n immunodetection cells, wherein n >2. Each immunodetection cell was used for detection of different immune functions.
Wherein the sample collection assembly 11 is used for collecting and dispensing a blood sample. The sample sucking assembly 11 comprises a sampling needle, a small-displacement syringe for sucking blood samples, a swab assembly for cleaning the sampling needle, a large-displacement syringe for cleaning diluent, a negative pressure assembly for sucking waste liquid in the cleaning sampling needle and the swab assembly, and a reversing valve and a pipeline connector for connecting the components.
The sampling needle is moved to a designated test well by a drive assembly 15 and then precisely dispensed to a designated test well, such as blood conventional test well 12, immune test well 13, by a small-displacement syringe in the sample-aspiration assembly 11.
The cleaning component 14 is used for cleaning the detection cell after the blood sample signal collection is completed, and adding base fluid to enable the detection cell to be in a ready state, cleaning a pipeline connected with the detection cell, and then returning the cleaning component 16 to an initial state, so that the follow-up of the next blood sample is not affected.
In some embodiments, the workflow of the blood testing device is: and controlling a sampling needle in the sample suction assembly 11 to suck a preset volume of blood sample to be detected, and then performing blood separation operation on the blood conventional detection pool 12 and the immune detection pool 13 according to a preset sequence, wherein the blood conventional detection pool and the immune detection pool detect the blood sample to obtain corresponding detection results.
In some embodiments, the blood conventional test cell 12 in the blood test apparatus 10 may not include a DIFF test cell.
Referring to fig. 2, fig. 2 is a schematic flow chart of a first embodiment of a blood sample distribution method provided in the present application. The method comprises the following steps:
step 21: and controlling the sampling needle to suck the blood sample to be detected.
In some embodiments, the blood testing device includes a sample-aspirating assembly for aspirating a blood sample to be tested. The sample sucking component comprises a sampling needle and a syringe A. Wherein, syringe A passes through the pipeline with the sampling needle and connects. When the blood sample to be detected is sucked, the sampling needle is controlled to move downwards into the blood sample container and enter the blood sample, the injector A works, and the sampling needle is controlled to suck the blood sample to be detected.
It will be appreciated that the volume of each blood sample drawn is determined on a per-demand basis.
In some embodiments, the volume of each draw of blood sample may be set to a fixed volume that can meet the blood sample requirements of all test items in the blood test device.
Step 22: control samples are subjected to a blood separation operation for the WBC detection cell.
In some embodiments, step 22 may be controlling the movement of the sampling needle over the WBC test cell and then injecting a second volume of blood sample to be tested into the WBC test cell.
In some embodiments, the sampling needle is controlled to expel a first volume of blood sample to be tested and to clean the outer wall of the sampling needle during movement of the sampling needle to the WBC test cell. After the sampling needle moves to the WBC detection cell, the sampling needle is controlled to inject a second volume of blood sample to be detected into the WBC detection cell.
Step 23: and controlling sampling to perform blood separation operation on the rest detection pools, wherein the rest detection pools at least comprise immune detection pools.
In some embodiments, the remaining test pools are validated according to the requirements of the current test. The detection requirements are WBC detection, multiple immunity detection and RBC detection. After the WBC detection pond is subjected to the blood separation operation, the plurality of immune detection ponds corresponding to the plurality of immune detection ponds are subjected to the blood separation operation, and after the plurality of immune detection ponds are subjected to the blood separation operation, the RBC detection pond is subjected to the blood separation operation.
In some embodiments, the WBC detection cells are homogenized during a control sample blood separation operation for the remaining detection cells.
In an application scenario, the following description refers to fig. 3:
firstly, the sampling needle is cleaned, and the sampling needle is controlled to suck the sample so as to suck the blood sample to be detected with a preset volume. Then the sampling needle is controlled to move to the WBC detection pond to perform blood throwing operation so as to control the sampling needle to throw away the first volume of blood sample to be detected, and then the WBC detection pond is controlled to perform blood dividing operation to distribute the second volume of blood sample to be detected. The sampling needle is controlled to move to the first immune detection cell to perform blood throwing operation so as to control the sampling needle to throw away the first volume of blood sample to be detected, then the first immune detection cell is subjected to blood dividing operation, the third volume of blood sample to be detected is distributed, and after the blood dividing operation is completed, the mixing operation is performed so that the third volume of blood sample to be detected is uniformly distributed in the first immune detection cell. At this time, the first immunodetection cell can perform the subsequent operations of blood sample calibration, channel detection, data acquisition, channel cleaning and the like. After the first immune detection cell is uniformly mixed with blood, the sampling needle is controlled to move to the nth immune detection cell for blood throwing operation, so that the sampling needle is controlled to throw away the first volume of blood sample to be detected, the nth immune detection cell is subjected to blood dividing operation, the fourth volume of blood sample to be detected is distributed, and after the blood dividing operation is finished, the mixing operation is performed, so that the fourth volume of blood sample to be detected is uniformly distributed in the nth immune detection cell. At this time, the nth immunodetection cell can perform the subsequent operations of blood sample calibration, channel detection, data acquisition, channel cleaning and the like. After the nth immune detection cell is subjected to blood separation and mixing, the sampling needle is controlled to move to the DIFF detection cell to perform blood throwing operation so as to control the sampling needle to throw away the first volume of blood sample to be detected, the DIFF detection cell is subjected to blood separation operation, the fifth volume of blood sample to be detected is distributed, and after the blood separation is finished, the mixing operation is performed so that the fifth volume of blood sample to be detected is uniformly distributed in the DIFF detection cell. At this time, the DIFF detection cell can perform subsequent operations such as blood sample calibration, channel detection, data collection, and channel cleaning. After the DIFF detection pool is evenly mixed with blood, the sampling needle is controlled to move to the WBC detection pool, the inner wall and the outer wall of the sampling needle are cleaned in the moving process, and after the cleaning is finished, the sampling needle is controlled to absorb liquid with a preset volume from the WBC detection pool. And then controlling the sampling needle to move to the RBC detection pool, and distributing the liquid with the preset volume to the RBC detection pool. After the sampling needle sucks the liquid with preset volume from the WBC detection pool, the reagent is added into the WBC detection pool to mix uniformly, and then the WBC can perform the working of channel detection, channel cleaning and the like. After the sampling needle is controlled to distribute the liquid with the preset volume to the RBC detection tank, the liquid in the RBC detection tank is uniformly mixed, and then the channel detection is carried out so as to carry out the channel cleaning and other works after the detection is completed.
It will be appreciated that when the sampling needle is performing a blood separation in the immunodetection cell and/or the DIFF detection cell, the WBC detection cell is simultaneously subjected to a bubble blending operation to avoid sedimentation of blood cells in the blood sample to be detected in the WBC detection cell.
In some embodiments, the blood test apparatus is not provided with a DIFF test cell, and no blood separation of the DIFF test cell is required when separating blood.
In this embodiment, compared to the prior art, the blood sample to be detected is sucked by controlling the sampling needle; controlling sampling to perform blood separation operation on the WBC detection pond; and controlling sampling to perform blood separation operation on the rest detection pools, wherein the rest detection pools at least comprise immune detection pools. On one hand, the WBC detection pond is subjected to blood separation operation preferentially, the volume of the blood sample to be detected, which is distributed to the WBC detection pond, is determined, the residence time of the blood sample to be detected, which is distributed to the WBC detection pond, in the sampling needle is reduced, the problem of sedimentation of blood cells in the blood sample to be detected in the sampling needle is solved, the quantity of the blood cells in the blood sample to be detected, which is distributed to the WBC detection pond, can be ensured, the accuracy of blood sample detection is improved, on the other hand, the joint progress of a plurality of detection items can be realized, and the detection efficiency is improved.
Referring to fig. 4, fig. 4 is a schematic flow chart of a second embodiment of a blood sample distribution method provided in the present application. The method comprises the following steps:
step 401: the sampling needle and swab assembly are controlled to move to the blood sample container.
In some embodiments, the sampling needle is disposed within the swab assembly. The swab assembly includes a first outlet and a second outlet. The first outlet is connected with the negative pressure component and is used for pumping out liquid in the swab component through the first outlet under the action of the negative pressure component. The second outlet is connected with a large-displacement syringe for providing diluent cleaning, and when the sampling needle needs to be cleaned, the large-displacement syringe injects the diluent into the swab component through the second outlet, and after cleaning, the negative pressure component pumps the diluent out through the first outlet.
Step 402: the sampling needle is controlled to move downwards, and the set volume of blood sample to be detected is sucked.
Step 403: and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the moving process.
It will be appreciated that when the sampling needle draws a set volume of blood sample to be tested, the outer wall of the sampling needle contacts the blood sample to be tested, which will adhere to a portion of the blood sample to be tested, and the portion of the blood sample to be tested contacts the air and is contaminated. The outer wall of the sampling needle is cleaned by injecting diluent into the swab assembly using a large-displacement syringe.
Step 404: the sampling needle is controlled to move to the WBC detection cell.
Step 405: a first volume of blood sample to be tested is dispensed to a WBC test cell.
Step 406: the liquid in the WBC detection cell is drained.
It will be appreciated that the sampling needle collects a sample of blood to be tested in the blood sample container, readily adsorbs debris when moving down and up through the sealing layer of the lancing blood sample container and moving out of the blood sample container, and by cleaning the outer wall of the sampling needle and dispensing a first volume of the sample of blood to be tested in the WBC test cell, a substantial portion of the debris can be removed therefrom with the fluid in the WBC test cell, thereby avoiding the impact of the debris on the blood test device, reducing the failure rate of the blood test device, and improving the test accuracy of the blood test device.
In some embodiments, steps 405 and 406 may be to dispense a first volume of blood sample to be tested in the swab assembly, and control the negative pressure assembly to draw the first volume of blood sample to be tested.
Step 407: a second volume of blood sample to be tested is dispensed to the WBC test cell.
It will be appreciated that the second volume of blood sample to be tested may be used as a subsequent test blood sample.
In some embodiments, after a second volume of blood sample to be tested is dispensed into the WBC test cell, the remaining components can be controlled to inject a base reagent into the WBC test cell to mix the second volume of blood sample to be tested.
Step 408: and performing blood separation operation on at least one immune detection cell according to a preset sequence.
In some embodiments, the immune items to be detected are acquired, the corresponding immune detection pools are acquired according to the immune items, and then the blood separation operation is performed on the immune detection pools corresponding to the immune items according to the preset sequence of the immune items. The immunization program to be detected is A, B, C. The immune item A corresponds to the immune detection pool A, the immune item B corresponds to the immune detection pool B, and the immune item C corresponds to the immune detection pool C. The priority of the immune projects is obtained, the immune projects with high priority are ordered according to the priority, and blood separation operation is carried out first.
In some embodiments, the fluid in the WBC test cells is homogenized during the blood sample distribution to at least one of the immune test cells. Specifically, the liquid in the WBC detecting cells can be uniformly mixed once in the process of distributing the blood sample in each immune detecting cell, so as to avoid sedimentation of blood cells in the WBC detecting cells.
In some embodiments, during the blood sample dispensing of the at least one immunodetection cell, the fluid in the WBC detection cell may be homogenized in a manner that the fluid in the WBC detection cell is homogenized at predetermined time intervals. Such as 2 seconds, 3 seconds, 5 seconds, and 10 seconds for the preset time interval. It will be appreciated that in practical situations, the preset time interval is set according to the requirements.
In some embodiments, the outer wall of the sampling needle is cleaned within the swab assembly prior to step 408.
In some embodiments, the specific steps of step 408 may be:
step 4081: and controlling the sampling needle and the swab assembly to move to the target immune detection cell.
Step 4082: the sampling needle is controlled to perform a blood throwing operation in the swab assembly.
It will be appreciated that the sampling needle is controlled to perform a blood throwing operation in the swab assembly and the negative pressure assembly is used to draw away the portion of the blood sample to be tested, avoiding cross-contamination between the channels.
Step 4083: and controlling the sampling needle to move downwards, and distributing the blood sample to be detected with a preset volume to a target immune detection pool.
In some embodiments, the sampling needle is controlled to move down into the interior of the target immunoassay well and a predetermined volume of blood sample to be tested is dispensed to the target immunoassay well.
Step 4084: and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the upward movement process.
In some embodiments, the sampling needle is controlled to move upwards, and in the upwards moving process, the large-displacement injector is controlled to inject the diluent into the swab assembly so as to clean the outer wall of the sampling needle, and the diluent after the cleaning is pumped away by utilizing the negative pressure assembly.
In some embodiments, after completion of step 4084, the sampling needle and swab assembly is controlled to move to the next target immunodetection pool and steps 4082-4084 described above are performed; until all the immune detection cells needed to be used complete blood separation operation.
Step 409: and performing blood separation operation on the DIFF detection cell.
In some embodiments, the specific steps of step 409 may be:
step 4091: the sampling needle and swab assembly are controlled to move to the DIFF detection cell.
Step 4092: the sampling needle is controlled to perform a blood throwing operation in the swab assembly.
It will be appreciated that the sampling needle is controlled to perform a blood throwing operation in the swab assembly and the negative pressure assembly is used to draw away the portion of the blood sample to be tested, avoiding cross-contamination between the channels.
Step 4093: the needle is controlled to move down and a predetermined volume of blood sample to be tested is dispensed to the DIFF test cell.
In some embodiments, the sampling needle is controlled to move down into the interior of the target immunoassay well and a predetermined volume of blood sample to be tested is dispensed to the DIFF test well.
Step 4094: and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the upward movement process.
In some embodiments, the sampling needle is controlled to move upwards, and in the upwards moving process, the large-displacement injector is controlled to inject the diluent into the swab assembly so as to clean the outer wall of the sampling needle, and the diluent after the cleaning is pumped away by utilizing the negative pressure assembly.
In some embodiments, if the blood test apparatus is not provided with a DIFF test cell, step 410 may be performed directly without performing step 409 when bleeding.
Step 410: and (5) performing blood separation operation on the RBC detection pool.
In some embodiments, step 410 may be preceded by the steps of:
step A: the sampling needle and swab assembly is controlled to move to the WBC detection cell.
After the completion of the blood separation operation on the DIFF test cell, the sampling needle and swab assembly is controlled to move to the WBC test cell.
And (B) step (B): the sampling needle is controlled to throw blood in the swab component, and the inner wall of the sampling needle is cleaned.
It can be understood that after the sampling needle separates blood into the DIFF detection cell, the residual blood sample to be detected in the sampling needle does not need to be used, and then diluent is injected into the sampling needle by using a large-displacement syringe, so that the residual blood sample to be detected in the sampling needle is completely pushed out to the swab component, the inner wall of the sampling needle is cleaned by using the diluent, and then the residual blood sample to be detected and the diluent are pumped away by using the negative pressure component and recycled to the waste liquid barrel.
Step C: the control sampling needle is moved down into the WBC detection cell and draws a portion of the liquid from the WBC detection cell.
It will be appreciated that the WBC test cell includes a mixed fluid in which a second volume of blood sample to be tested is mixed.
Step D: and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the upward movement process.
In some embodiments, the sampling needle is controlled to move upwards, and in the upwards moving process, the large-displacement injector is controlled to inject the diluent into the swab assembly so as to clean the outer wall of the sampling needle, and the diluent after the cleaning is pumped away by utilizing the negative pressure assembly.
In some embodiments, the specific steps of step 410 may be:
step 4101: the sampling needle and swab assembly is controlled to move to the RBC test cell.
In some embodiments, after the sampling needle draws a portion of the fluid from the WBC detection cell, the sampling needle and swab assembly are controlled to move to the RBC detection cell.
Step 4102: the sampling needle is controlled to perform a blood throwing operation in the swab assembly.
In some embodiments, the bleeding operation at this time is to discard a portion of the volume of liquid from the portion of liquid drawn from the WBC test cell, avoiding channel contamination.
Step 4103: the sampling needle is controlled to move downwards and part of liquid in the sampling needle is distributed to the RBC detection pool.
It will be appreciated that there is some liquid in the needle that is drawn from the WBC detection cell at this point, the needle is controlled to move down and some liquid in the needle is dispensed to the RBC detection cell.
Step 4104: and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the upward movement process.
In some embodiments, the sampling needle is controlled to move upwards, and in the upwards moving process, the large-displacement injector is controlled to inject the diluent into the swab assembly so as to clean the outer wall of the sampling needle, and the diluent after the cleaning is pumped away by utilizing the negative pressure assembly.
After the completion of the execution of step 4104, the sampling needle is cleaned and controlled to move to the initial position for the next blood sample aspiration.
In an application scenario, the following is described with reference to fig. 8:
the sampling needle and the swab component are controlled to move to a sample sucking position, and the high-precision small-displacement syringe sucks the volume of the blood sample to be detected required by the current counting according to the time sequence requirement, and as shown in fig. 8, the blood sample to be detected is distributed into b1, b2, a1, a2, an, delta a, b3, b4, b5 and the like according to the volume.
After the sample is sucked, the sampling needle is lifted upwards to return to the initial position of the vertical position, meanwhile, in the lifting process of the sampling needle, the large-displacement syringe and the valve assembly start to work, diluent is provided, the outer wall of the sampling needle is cleaned in the swab assembly, the negative pressure assembly is also started at the same time, and the diluent used for cleaning in the swab assembly is timely pumped away, so that the outer wall of the sampling needle is ensured to be clean.
Then the sampling needle and the swab component are controlled to run into the WBC detection pool, the head blood b1 part of the sampling needle is firstly spitted out in the WBC detection pool and is discharged along with the bottom liquid in the WBC detection pool, and then the sampling needle is controlled to distribute b2 volumes of blood to be detected into the WBC detection pool. The blood is firstly separated into the WBC detection pool, so that no matter what detection items are selected, the positions of the blood sample to be detected, which is separated into the WBC detection pool each time, in the sampling needle can be guaranteed to be the same, the consistency of the blood separation can be guaranteed, and the repeatability and the stability of the measurement result can be improved; meanwhile, the sampling needle is easy to have scraps during puncture, and most scraps can be discharged together with the bottom liquid of the WBC detection pond by cleaning the sampling needle part and spitting head blood in the WBC detection pond, so that the failure rate of the instrument can be reduced to a great extent.
After the WBC detection cell is completely bled, the sampling needle and the swab component are controlled to move to the immune detection cell x1. When the sampling needle runs to the upper side of the immune detection pool x1, the sampling needle firstly spits out the blood sample to be detected with the delta a volume in the swab component, and the blood sample is pumped away by the negative pressure component, so that cross contamination of a detection channel is avoided. Then the sampling needle is controlled to move down to the inside of the immune detection pool x1, a 1-delta a volume of blood sample to be detected is distributed to the immune detection pool x1, and the blood sample to be detected is fused into an immunoreagent through a mixing pipeline of the immune detection pool x1, so that the blood separation action of an x1 channel of the immune detection pool is completed.
After the immune detection cell x1 is completely bled, the sampling needle and the swab component are controlled to move to the immune detection cell x2. When the sampling needle runs to the position vertically above the immune detection pool x2, the sampling needle firstly spits out the blood sample to be detected with the delta a volume in the swab component, and the blood sample is pumped away by the negative pressure component, so that cross contamination of a detection channel is avoided. Then the sampling needle is controlled to move down to the inside of the immune detection pool x2, a 2-delta a volume of blood sample to be detected is distributed to the immune detection pool x2, and the blood sample to be detected is fused into an immunoreagent through a mixing pipeline of the immune detection pool x2, so that the blood separation action of an x2 channel of the immune detection pool is completed.
After the immune detection cell x2 is completely bled, the sampling needle and the swab component are controlled to move to the immune detection cell x3. When the sampling needle runs to the upper side of the immune detection pool x3 vertically, the sampling needle firstly spits out the blood sample to be detected with the delta a volume in the swab component, and the blood sample is pumped away by the negative pressure component, so that cross contamination of a detection channel is avoided. Then the sampling needle is controlled to move down to the inside of the immune detection pool x3, a 3-delta a volume of blood sample to be detected is distributed to the immune detection pool x3, and the blood sample to be detected is fused into an immunoreagent through a mixing pipeline of the immune detection pool x3, so that the blood separation action of an x3 channel of the immune detection pool is completed.
According to the steps, the sampling needle and the swab component are controlled to move to the immune detection pool xn. When the sampling needle runs to the position vertically above the immune detection pool xn, the sampling needle firstly spits out the blood sample to be detected with the delta a volume in the swab component, and the blood sample is pumped away by the negative pressure component, so that cross contamination of a detection channel is avoided. Then the sampling needle is controlled to move down to the inside of the immune detection pool xn, an a-delta a volume of blood sample to be detected is distributed to the immune detection pool xn, and the blood sample to be detected is fused into an immunoreagent through a mixing pipeline of the immune detection pool xn, so that the blood separation action of an xn channel of the immune detection pool is completed. The immune channel was completed by this time.
Because the application is that the WBC detection pond is firstly divided into blood and then the blood is divided into the immune detection pond, the time from the completion of the blood division of the WBC detection pond to the start of detection needs to be longer, the time length is related to the number of the selected immune detection pond, the sedimentation of blood cells in the WBC detection pond is avoided, the subsequent secondary sample suction is ensured to be uniform, and the WBC detection pond is subjected to primary bubble mixing operation every time the blood is divided into the immune detection pond.
After the immune detection cell xn is used for separating blood, the sampling needle and the swab component are controlled to move to the DIFF detection cell. When the sampling needle runs to the vertical upper part of the DIFF detection pool, the sampling needle spits out b3 volume of blood sample to be detected in the swab component, and the blood sample is pumped away by the negative pressure component, so that cross contamination of a channel is avoided. Then the sampling needle is controlled to move down to the inside of the DIFF detection cell, b4 volumes of blood to be detected are distributed to the DIFF detection cell, and the blood distribution of the DIFF detection cell is completed.
After the DIFF detection cell is completely bled, the sampling needle and the swab assembly are controlled to move to the WBC detection cell. In the moving process, the sampling needle is lifted, and meanwhile, diluent is added to the swab component through the large-displacement syringe, so that the outer wall of the sampling needle is cleaned. When the needle point of the sampling needle reaches the inside of the swab component, the large-displacement injector is used as power to inject diluent into the sampling needle, and the residual b5 volume of blood sample to be detected in the sampling needle is completely pushed out and the inner wall of the sampling needle is cleaned. And recycling the waste liquid barrel by utilizing the negative pressure component. After the sampling needle moves to the WBC detection pond, a diluent injector is used as power to absorb a certain amount of mixed partial liquid in the WBC detection pond as blood sample liquid in the RBC detection pond.
And controlling the sampling needle and the swab component to move to the RBC pool, injecting the sucked partial liquid into the sampling needle by using the large-displacement injector as power, and distributing the partial liquid and the partial diluent to the RBC detection pool so as to complete the blood separation and sample addition of the RBC detection pool. Finally, the sampling needle and the swab assembly are controlled to return to the initial position.
In some embodiments, the blood sample dispensed to the WBC test cell is determined inside the sampling needle, and the blood sample at the remaining location may be dispensed to the remaining test cell at the fixed location. The method can be used for preferentially arranging and distributing the blood samples to the immune detection cell with long detection time or more urgent need, flexibly arranging and distributing the sequence of the blood samples and accelerating the whole detection flow.
As shown in fig. 9, a sampling needle 91 in the blood test apparatus is connected to a tube 92, and then the sampling needle 91 is controlled to suck a blood sample, and a corresponding volume of the blood sample is stored in the sampling needle 91 and the tube 92. As shown in fig. 9, the sampling needle 91 is divided into a section a, a section B, a section C and a section D; the blood sample in the section D is used as head blood, and the blood sample in the section A is used for detection items with high priority, such as immunization items and classification items; the blood sample in section B is used for routine blood tests, such as WBC tests. The blood sample in section C and line 92 is used for the remaining test items.
By the method, the blood sample can be preferentially distributed to the detection tanks of the detection items with long detection time or more urgent need, the sequence of distributing the blood sample is flexibly arranged, the detection efficiency of the whole detection flow is improved, the position of the blood sample distributed to the blood routine detection tank is fixed in the sampling needle, the residence time of the blood sample to be detected distributed to the blood routine detection tank in the sampling needle is reduced, the problem of blood cell sedimentation in the blood sample to be detected in the sampling needle is solved, the quantity of blood cells in the blood sample to be detected distributed to the blood routine detection tank (such as the WBC detection tank) can be ensured, and the accuracy of blood sample detection is improved.
In this embodiment, by the above manner, on one hand, the volume of the blood sample to be detected, which is distributed to the WBC detection cell, is determined by preferentially performing the blood separation operation on the WBC detection cell, and the residence time of the blood sample to be detected, which is distributed to the WBC detection cell, in the sampling needle is reduced, so that the problem of sedimentation of blood cells in the blood sample to be detected in the sampling needle is improved, the number of blood cells in the blood sample to be detected, which is distributed to the WBC detection cell, can be ensured, the accuracy of blood sample detection is improved, and on the other hand, the joint progress of a plurality of detection items can be realized, and the detection efficiency is improved.
Referring to fig. 10, fig. 10 is a schematic structural diagram of another embodiment of a blood test apparatus provided in the present application. The blood test apparatus 100 includes a processor 101 and a memory 102 connected to the processor 101; the memory 102 is used for storing program data and the processor 101 is used for executing the program data to implement the following method steps:
controlling a sampling needle to suck a blood sample to be detected; controlling sampling to perform blood separation operation on the WBC detection pond; and controlling sampling to perform blood separation operation on the rest detection pools, wherein the rest detection pools at least comprise immune detection pools.
It will be appreciated that the method described in any of the embodiments above may also be implemented when the processor 101 is configured to execute program data.
Referring to fig. 11, fig. 11 is a schematic structural diagram of an embodiment of a computer readable storage medium provided in the present application. The computer readable storage medium 110 is for storing program data 111, which program data 111, when executed by a processor, is for carrying out the method steps of:
controlling a sampling needle to suck a blood sample to be detected; controlling sampling to perform blood separation operation on the WBC detection pond; and controlling sampling to perform blood separation operation on the rest detection pools, wherein the rest detection pools at least comprise immune detection pools.
It will be appreciated that the program data 111, when executed by a processor, may also implement the method described in any of the embodiments above.
In the several embodiments provided in the present application, it should be understood that the disclosed methods and apparatuses may be implemented in other manners. For example, the above-described device embodiments are merely illustrative, e.g., the division of the modules or units is merely a logical functional division, and there may be additional divisions when actually implemented, e.g., multiple units or components may be combined or integrated into another system, or some features may be omitted, or not performed.
The units described as separate units may or may not be physically separate, and units shown as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the embodiment.
In addition, each functional unit in each embodiment of the present application may be integrated into one processing unit, each unit may exist alone physically, or two or more units may be integrated into one unit. The integrated units may be implemented in hardware or in software functional units.
The integrated units of the other embodiments described above may be stored in a computer readable storage medium if implemented in the form of software functional units and sold or used as stand alone products. Based on such understanding, the technical solution of the present application may be embodied in essence or a part contributing to the prior art or all or part of the technical solution, in the form of a software product stored in a storage medium, including several instructions to cause a computer device (which may be a personal computer, a server, or a network device, etc.) or a processor (processor) to perform all or part of the steps of the methods described in the embodiments of the present application. And the aforementioned storage medium includes: a U-disk, a removable hard disk, a Read-Only Memory (ROM), a random access Memory (RAM, random Access Memory), a magnetic disk, or an optical disk, or other various media capable of storing program codes.
The foregoing description is only of embodiments of the present application, and is not intended to limit the scope of the patent application, and all equivalent structures or equivalent processes using the descriptions and the contents of the present application or other related technical fields are included in the scope of the patent application.
Claims (9)
1. A method of dispensing a blood sample, the method comprising:
controlling a sampling needle to suck a blood sample to be detected;
controlling the sampling to perform blood separation operation on the WBC detection cell;
performing blood separation operation on at least one immune detection cell according to a preset sequence;
performing blood separation operation on the DIFF detection cell;
controlling the sampling needle to draw a portion of the fluid from the WBC detection cell,
and (3) performing a blood separation operation on the RBC detection pool based on the part of the liquid.
2. The method of claim 1, wherein the step of determining the position of the substrate comprises,
the method further comprises the steps of:
and in the process of distributing blood samples in the at least one immune detection cell, uniformly mixing the liquid in the WBC detection cell.
3. The method of claim 2, wherein the step of determining the position of the substrate comprises,
the step of uniformly mixing the liquid in the WBC detection pond in the process of blood sample distribution of the at least one immunity detection pond comprises the following steps:
and in the process of distributing blood samples to each immune detection cell, carrying out one-time uniform mixing operation on the liquid in the WBC detection cell.
4. The method of claim 1, wherein the step of determining the position of the substrate comprises,
the blood separation operation is carried out on at least one immune detection cell according to a preset sequence, and the blood separation operation comprises the following steps:
controlling the sampling needle and the swab component to move to a target immune detection pool;
controlling the sampling needle to perform a blood throwing operation in the swab assembly;
controlling the sampling needle to move downwards, and distributing the blood sample to be detected with a preset volume to the target immune detection pool;
and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the upward movement process.
5. The method of claim 1, wherein the step of determining the position of the substrate comprises,
the blood separation operation is carried out on the DIFF detection cell, and the blood separation operation comprises the following steps:
controlling the sampling needle and swab assembly to move to a DIFF detection cell;
controlling the sampling needle to perform a blood throwing operation in the swab assembly;
controlling the sampling needle to move downwards and distributing the blood sample to be detected with a preset volume to the DIFF detection cell;
and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the upward movement process.
6. The method of claim 1, wherein the step of determining the position of the substrate comprises,
the controlling the sampling needle to draw a portion of the liquid from the WBC detection cell includes:
controlling the sampling needle and swab assembly to move to a WBC detection cell;
controlling the sampling needle to throw blood in the swab component, and cleaning the inner wall of the sampling needle;
controlling the sampling needle to move downwards into the WBC detection cell and sucking part of liquid from the WBC detection cell;
and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the upward movement process.
7. The method of claim 6, wherein the step of providing the first layer comprises,
the blood separation operation is carried out on the RBC detection pool, which comprises the following steps:
controlling the sampling needle and the swab assembly to move to an RBC detection pool;
controlling the sampling needle to perform a blood throwing operation in the swab assembly;
controlling the sampling needle to move downwards and distributing part of liquid in the sampling needle to the RBC detection pool;
and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the upward movement process.
8. A blood testing device, comprising a processor and a memory coupled to the processor; the memory is configured to store program data and the processor is configured to execute the program data to implement the method of any one of claims 1-7.
9. A computer readable storage medium for storing program data which, when executed by a processor, is adapted to carry out the method of any one of claims 1-7.
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