CN114042126B - A traditional Chinese medicine composition for raising qing, removing turbidity, removing dampness, nourishing qi, slimming and lipid-lowering and preparation method thereof - Google Patents
A traditional Chinese medicine composition for raising qing, removing turbidity, removing dampness, nourishing qi, slimming and lipid-lowering and preparation method thereof Download PDFInfo
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Abstract
本发明公开了一种升清化浊利湿益气减肥降脂中药组合物，由下述重量份的药材配制而成：人参12~24份、荷叶12~24份、茯苓15~24份、桑葚8~12份、百合8~12份、佛手12~18份、菊花8~12份、淡竹叶12~18份、铁皮石斛12~18份、山楂12~18份、炒决明子12~18份、莲子8~12份和杜仲叶8~12份，将药材破壁处理后，采用瞬时压差工艺提取，然后过滤，减压浓缩得稠膏，减压干燥制得药粉，把药粉粉碎，机械均化、包装得到中药制剂。The invention discloses a traditional Chinese medicine composition for promoting clearing, removing turbidity, removing dampness, benefiting qi, losing weight and lowering lipids, which is prepared from the following medicinal materials in parts by weight: 12-24 parts of ginseng, 12-24 parts of lotus leaf, and 15-24 parts of Poria cocos , 8~12 parts mulberry, 8~12 parts lily, 12~18 parts bergamot, 8~12 parts chrysanthemum, 12~18 parts light bamboo leaves, 12~18 parts Dendrobium officinale, 12~18 parts hawthorn, 12~18 parts fried cassia seeds parts, 8-12 parts of lotus seeds and 8-12 parts of Eucommia ulmoides leaves, after the medicinal materials are broken into walls, extracted by instantaneous pressure difference process, then filtered, concentrated under reduced pressure to obtain a thick paste, dried under reduced pressure to obtain medicinal powder, pulverized the medicinal powder, The traditional Chinese medicine preparation is obtained by mechanical homogenization and packaging.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition for ascending the clear, eliminating turbid, promoting diuresis, benefiting qi, losing weight and reducing fat and a preparation method thereof.
Background
With the progress of society and the rapid development of economy, the living standard of people is gradually improved. Meanwhile, more and more people have excess nutrition, and in the modern society with fast life rhythm, people hardly do exercise, so that the number of simple obese patients is greatly increased. Simple obesity is an independent chronic disease widely prevalent in the world and mainly characterized by excessive fat accumulation in the body. According to the data of research and investigation, the problem of overweight and obesity is continuously highlighted, and the obesity rate of men and women of residents aged 18 and older is increased year by year. Obesity is a fulcrum for prying diabetes, hypertension, various cardiovascular and cerebrovascular diseases and cancers. It not only affects the beauty of human body, but also seriously affects the living quality of people. In the face of the problem of obesity which is eye-surprised, people deserve to think that an effective weight-reducing prescription is researched. The research shows that if the transportation, transformation and catharsis of the internal organs such as the spleen, the stomach, the kidney, the lung and the like of a human body are disordered, so that phlegm-dampness is accumulated in the human body, the obesity can be caused. The traditional Chinese medicines for soothing the liver, strengthening the spleen, promoting diuresis, excreting dampness, ascending the clear, eliminating turbid, benefiting the stomach, promoting the production of body fluid and the like are effective in treating obesity from phlegm-dampness, and can solve the obesity caused by simple spleen deficiency and dampness.
Disclosure of Invention
In order to solve the serious obesity problem, an effective and simple treatment scheme is provided for the obese patients. The invention provides a traditional Chinese medicine preparation which has simple formula, easily obtained component sources, obvious curative effect and convenient carrying, and has the obvious effects of ascending the clear and eliminating turbid pathogen, promoting diuresis, tonifying qi, losing weight and reducing fat. The invention focuses on regulating qi of spleen and stomach, is compatible with each other, is matched with traditional Chinese medicines for tonifying qi and spleen and promoting blood circulation to remove turbid urine on the premise of ascending the clear and resolving turbidity, and promoting diuresis and excreting dampness, and plays the roles of eliminating dampness and reducing phlegm, promoting blood circulation to remove turbid urine, tonifying qi and spleen, and relaxing bowel together, thereby finally achieving the purposes of losing weight and reducing fat. In the formula, ginseng, lotus leaf and tuckahoe are used as monarch drugs; mulberry, lily, chrysanthemum, fingered citron, lophatherum gracile, dendrobium officinale and hawthorn are used as ministerial drugs; parched semen Cassiae, semen Nelumbinis, and folium Eucommiae as adjuvant drugs.
The invention is realized by the following technical scheme: a traditional Chinese medicine composition for ascending the clear, resolving turbidity, promoting diuresis, benefiting qi, losing weight and reducing fat is prepared from the following medicinal materials in parts by weight: 12-24 parts of ginseng, 12-24 parts of lotus leaf, 15-24 parts of poria cocos, 8-12 parts of mulberry, 8-12 parts of lily, 12-18 parts of fingered citron, 8-12 parts of chrysanthemum, 12-18 parts of lophatherum gracile, 12-18 parts of dendrobium officinale, 12-18 parts of hawthorn, 12-18 parts of fried cassia seed, 8-12 parts of lotus seed and 8-12 parts of eucommia leaf.
Further preferably, the traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 24 parts of ginseng, 16 parts of lotus leaf, 18 parts of poria cocos, 10 parts of mulberry, 8 parts of lily, 16 parts of fingered citron, 10 parts of chrysanthemum, 16 parts of lophatherum gracile, 16 parts of dendrobium officinale, 12 parts of hawthorn, 15 parts of fried cassia seed, 8 parts of lotus seed and 8 parts of eucommia leaf.
Further preferably, the traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 12 parts of ginseng, 20 parts of lotus leaf, 15 parts of poria cocos, 10 parts of mulberry, 8 parts of lily, 12 parts of fingered citron, 10 parts of chrysanthemum, 16 parts of lophatherum gracile, 12 parts of dendrobium officinale, 12 parts of hawthorn, 18 parts of fried cassia seed, 10 parts of lotus seed and 8 parts of eucommia leaf.
The invention is preferably a genuine medicinal material, the ginseng selected by the invention is produced from northeast, the lotus leaf is produced from Jiangxi, the poria cocos is produced from Yunnan, the mulberry is produced from Anhui, the lily is produced from Hunan West, the chrysanthemum is produced from Anhui, the fingered citron is produced from Guangdong, the lophatherum gracile is produced from Anhui, the dendrobium officinale is produced from Yunnan, the hawthorn is produced from Shandong, the cassia seed is produced from Anhui, the lotus seed is produced from Jiangxi, and the eucommia bark leaf is produced from Sichuan.
The traditional Chinese medicine composition with the formula of ascending the clear, eliminating turbid, promoting diuresis, benefiting qi, losing weight and reducing fat provided by the invention can be directly decocted for oral administration, and can also be prepared into a traditional Chinese medicine preparation, such as granules or capsules. The traditional Chinese medicine preparation for ascending the clear, eliminating the turbid, promoting diuresis, tonifying qi, losing weight and reducing fat has the advantages of simple formula, easily obtained component types, convenience in carrying and eating, good patient compliance, no side effect and capability of being eaten by patients for a long time. The invention achieves the purpose of conditioning the disease and treating the external diseases by the lipid regulating effect of the components such as lotus leaves and the like, the functions of ascending the clear and dissolving the turbid, and the functions of ginseng and tuckahoe, such as diuresis and qi benefiting. The traditional Chinese medicine preparation is particularly suitable for treating phlegm-damp obesity symptoms caused by long-term liver-qi stagnation, spleen deficiency, insomnia and body metabolism regulation dysfunction.
The invention also provides a preparation method of the traditional Chinese medicine preparation for ascending the clear, eliminating the turbid, promoting diuresis, benefiting qi, losing weight and reducing fat, which comprises the following steps:
s1: preparing medicinal materials: weighing 12-24 parts of ginseng, 12-24 parts of lotus leaf, 15-24 parts of poria cocos, 8-12 parts of mulberry, 8-12 parts of lily, 12-18 parts of fingered citron, 8-12 parts of chrysanthemum, 12-18 parts of lophatherum gracile, 12-18 parts of dendrobium officinale, 12-18 parts of hawthorn, 12-18 parts of fried cassia seed, 8-12 parts of lotus seed and 8-12 parts of eucommia leaf, respectively cleaning, cutting, airing at normal temperature, and putting the materials into a wall breaking machine together for wall breaking for 5-15 min;
s2: extraction: adding the mixture of the medicinal materials obtained by breaking the wall in the step S1 into an extraction tank, adding distilled water to submerge all the medicinal materials, soaking for 2-3 h, decocting for 1-1.5 h for the first time, and collecting decoction; adding distilled water into the residues obtained after the first decoction, decocting for 0.5-1 h for the second time, and collecting the decoction again; combining the two collected decoctions;
s3: preparing medicinal powder: filtering the decoction, concentrating the filtrate under reduced pressure by a concentration drying device under the conditions of-0.09 Mpa and 40-60 ℃ to obtain thick paste with the relative density of 1.30-1.40, drying the thick paste under reduced pressure under-0.09 Mpa and 40-60 ℃ to obtain medicinal powder;
s4: preparation: and (4) crushing the medicinal powder obtained in the step (S3), mechanically homogenizing, sieving by a 16-20-mesh sieve, grading, and subpackaging by a 10-30 g medicinal bag or a capsule shell to prepare a capsule.
Preferably, in step S1, 30 parts of ginseng, 10 parts of lotus leaf, 15 parts of poria cocos, 5 parts of mulberry, 15 parts of lily, 10 parts of fingered citron, 5 parts of chrysanthemum, 10 parts of lophatherum gracile, 10 parts of dendrobium officinale, 10 parts of hawthorn, 15 parts of fried cassia seed, 10 parts of lotus seed and 3 parts of folium cortex eucommiae are weighed according to parts by weight.
Preferably, in step S2, during the decoction process, repeatedly pressurizing and depressurizing to form an instantaneous pressure difference, first pressurizing to 0.1-0.5 Mpa, maintaining the pressure for 30-180S, then depressurizing, and vacuumizing to-0.1 Mpa to form an instantaneous pressure difference to promote the effective components of the drug to be separated out, and repeating the steps until the extraction is finished.
Preferably, in step S2, the mass ratio of the distilled water to the medicinal materials is 5-6: 1 during the first decoction; and (3) adding distilled water into the second decoction and the subsequent decoction according to the mass ratio of the distilled water to the decoction dregs of a decoction of 3-4: 1.
Preferably, in step S2, during the first batch of decoction, the decoction is taken to perform near infrared spectroscopy and medicinal material content measurement, a near infrared spectroscopy and medicinal material content correlation model is established, and the decoction endpoint is determined according to the measurement value of the on-line near infrared spectroscopy detection device in the subsequent decoction process.
In the formula of the traditional Chinese medicine preparation, the effects and the characteristics of the traditional Chinese medicine components are as follows:
ginseng: it has effects in invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting salivation, nourishing blood, tranquilizing mind, and improving intelligence.
Lotus leaf: clear summer-heat, resolve dampness, raise hair, clear yang, cool blood and stop bleeding. Can be used for treating summer heat, polydipsia, summer damp diarrhea, spleen deficiency diarrhea, blood heat, hematochezia, metrorrhagia and metrostaxis.
Tuckahoe, Poria promotes diuresis and eliminates dampness, strengthens spleen and calms heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, peaceful diarrhea, uneasiness, palpitation, and insomnia.
And (3) mulberry fruit: has effects in dispelling pathogenic wind and heat, clearing lung-heat, moistening dryness, removing liver heat, and improving eyesight.
Lily: has effects in nourishing yin, moistening lung, clearing away heart-fire, and tranquilizing mind. Can be used for treating dry cough due to yin deficiency, cough with hemoptysis, vexation, pavor, insomnia, dreaminess, and absentmindedness.
Fingered citron: has effects in dispersing stagnated liver qi, regulating stomach function, relieving pain, eliminating dampness, and eliminating phlegm. Can be used for treating stagnation of qi of liver and stomach, distending pain in chest and hypochondrium, flatulence, fullness, anorexia, emesis, cough and excessive phlegm.
Chrysanthemum: has effects in removing liver heat, promoting bile flow, invigorating stomach, resolving food stagnation, inducing diuresis, and relieving swelling. Can be used for treating jaundice due to damp-heat pathogen, stomach ache, anorexia, edema, and oliguria.
Herba lophatheri: relieve exterior syndrome, relieve restlessness, disperse stagnated heat. Can be used for treating common cold, headache due to cold and heat, dysphoria, chest distress, and insomnia due to vexation.
Dendrobium officinale: has effects in invigorating stomach, promoting salivation, nourishing yin, and clearing away heat. Can be used for treating fever, body fluid consumption, dry mouth, polydipsia, stomach yin deficiency, anorexia, retching, asthenia heat, yin deficiency, hyperactivity of fire, bone steaming, fatigue, dim eyesight, and flaccidity of tendons and bones.
Hawthorn fruit: promoting blood circulation, removing blood stasis, regulating qi, dredging collaterals, eliminating turbid pathogen, and reducing blood lipid. Can be used for treating qi stagnation and blood stasis, thoracic obstruction, cardiodynia, chest distress, palpitation, amnesia, vertigo, tinnitus, and hyperlipidemia.
Parching semen Cassiae: has effects in clearing away heat, improving eyesight, and loosening bowel to relieve constipation. Can be used for treating conjunctival congestion, photophobia, lacrimation, headache, vertigo, dim eyesight, and constipation.
Lotus seed: tonify spleen to check diarrhea, stop leukorrhagia, tonify kidney to arrest seminal emission, nourish heart to induce tranquilization. Can be used for treating diarrhea due to spleen deficiency, leukorrhagia, spermatorrhea, palpitation, and insomnia.
Eucommia leaves: has effects in nourishing liver and kidney, and strengthening tendons and bones. Can be used for treating deficiency of liver and kidney, dizziness, soreness of waist and knees, and flaccidity of tendons and bones.
The 13 components used in the invention, namely ginseng, lotus leaf, tuckahoe, mulberry, lily, fingered citron, chrysanthemum, lophatherum gracile, dendrobium officinale, hawthorn, fried cassia seed, lotus seed and eucommia leaf, are all from the homology of medicine and food catalogue issued by the Weijian Commission of China, and almost have no side effect.
The invention is characterized in the following aspects:
firstly, the particularity of compatibility:
the major treatise on Su Wen and six micro-ideas is recorded in the book: "go up and down and go in and out without any apparatus. Therefore, this is the organ of biochemistry. The organ is divided into . Therefore, the device is free from going in and out and lifting. In the human body, the spleen and stomach are the pivot of qi movement, the spleen is the viscera of damp earth of taiyin, the stomach is the fu-organs of dry earth of yang-improving, yin-yang-ascending and yang-descending of the spleen and stomach can produce the intercourse and movement of yin and yang, so as to complete the accepting, transportation and transformation processes of food essence, the spleen governs ascending, clearing, stomach governing descending, turbid and the mutual cooperation of the two to maintain the normal physiological function. The theory of the spleen and stomach mentions that: "or lack of food but fat, but fat but not lifted by limbs, covered by spleen and excessive pathogenic qi". The spleen governs transportation and transformation, and dysfunction of transportation and transformation leads to disorder of qi movement, and food can not be transformed into fine substances to nourish the whole body, but instead accumulates in the body, so that dampness is endogenous, and obesity is caused for a long time. The records of Jingyue quan Shu, miscellaneous syndrome plan, non-wind: "fattened person is wet and stagnant". Therefore, the pathogenesis of obesity is mainly determined by spleen and stomach, and the pathogenesis of the disease is phlegm-dampness and qi deficiency, and the disease should regulate the qi activity of the human body, ascend the clear and resolve the turbid, promote diuresis and tonify qi. The traditional Chinese medicine composition for ascending the clear, resolving the turbid, promoting diuresis, tonifying qi, losing weight and reducing fat is prepared from the aspects of strengthening the spleen, harmonizing the stomach, tonifying qi and drying dampness, so that the problem of clinical obesity is prevented and treated.
The formula of the invention comprises the following monarch drugs: ginseng, lotus leaf, tuckahoe. The three medicines enter spleen and stomach channels, and can strengthen spleen and replenish qi, eliminate dampness and promote diuresis, relax bowel without hurting spleen, and play the roles of strengthening middle-jiao and replenishing qi, strengthening spleen and eliminating dampness. The compatibility of ginseng, lotus leaf and tuckahoe mainly aims at qi and blood disorder caused by viscera dysfunction, abnormal circulation of body fluid, long-term accumulation of turbid phlegm and accumulation of damp phlegm to cause obesity. In the formula, the three herbs of Ginseng, Lotus leaf and Poria are added to raise the clear and descend the turbid, so as to resolve the damp-turbidity qi. The transportation and transformation functions of the human body are strengthened by regulating stomach qi.
Modern pharmacological research shows that ginseng has the effects of reducing blood sugar, regulating energy metabolism and promoting the immune function of organisms; the effective components of the lotus leaf have the effects of regulating blood fat, resisting lipid peroxidation, inhibiting bacteria and the like; poria has diuretic effect, and single herb has no longer diuretic effect than compound prescription. The three medicinal materials are used for the major part of the recipe, one is to take the effect of inducing diuresis and excreting dampness, the other two is to be used together, which also has the effect of consolidating the constitution and tonifying qi.
The prescription of the invention comprises the following ministerial drugs: mulberry, lily, chrysanthemum, fingered citron, lophatherum gracile, dendrobium officinale and hawthorn. The invention predicts the functions of tonifying qi, removing dampness, ascending the clear and eliminating the turbid through the analysis of the effect target of the monarch drug. The combination of the principal drugs is called earth-banking and vital-gold-generating, and the effect of regulating lung and regulating qi is achieved by regulating the pivot of qi and spleen and stomach. The ministerial drugs assist each other, and on the basis of excreting dampness and reducing diarrhea, the ministerial drugs help the monarch drugs to protect the qi of the middle jiao, strengthen the body resistance and strengthen the origin, thereby fundamentally improving the phlegm-dampness obesity constitution. The mulberry can enrich blood, nourish yin, clear away lung-heat, moisten dryness, and the lophatherum gracile can drain dampness and purge fire, and can help the ginseng and the tuckahoe to invigorate spleen, replenish qi, promote qi circulation and reduce phlegm; the lily has the effects of clearing away heart-fire and tranquilizing the mind, and the chrysanthemum has the effects of dispelling wind and clearing heat, and the lily and the chrysanthemum together help the poria to invigorate spleen and assist transportation, and excrete dampness and relieve diarrhea; the fingered citron has the effects of regulating qi and harmonizing stomach, eliminating dampness and phlegm, and assisting the tuckahoe to remove dampness, and the dendrobium officinale, the dendrobium officinale and the dendrobium officinale, which are compatible with the stomach tonifying and body fluid production, have the effects of removing dampness and tonifying stomach; haw promotes blood circulation to remove blood stasis, promotes digestion to eliminate stagnation, and can not only promote qi circulation and harmonize stomach, help the action of dehumidification, but also dredge qi movement.
The formula of the invention comprises the following adjuvant drugs: parched semen Cassiae, semen Nelumbinis, and folium Eucommiae. When the turbid qi of the human body rises, the basal metabolic rate is reduced, and the pathogenesis of the traditional Chinese medicine is that the spleen qi is not transported further, the damp turbidity stops internally, the spleen qi accumulates in the body and turns into grease, the earth is congested and full, and the obesity is born from the condition. Therefore, the reduction of turbidity, the discharge of turbidity and the discharge of metabolites out of the body are problems to be solved urgently in obesity. The invention aims at the problem and adopts the compatibility of a plurality of medicinal materials. The fried cassia seed has the effects of lubricating the intestines and clearing heat, and helping lotus leaves to ascend clear, resolve dampness and eliminate food retention, and the lotus leaves, the turbid pathogen and the food retention can be combined with the cassia seed to tonify qi, moisten the lung, invigorate the spleen, promote qi circulation, eliminate food retention and eliminate dampness; lotus seed and eucommia bark leaf can tonify spleen and kidney, benefit liver and kidney, reinforce kidney and replenish qi, and strengthen tendons and bones.
In the overall formula, the ginseng, the lotus leaf and the tuckahoe which have the effects of ascending the clear, resolving the turbid, promoting diuresis and tonifying qi are taken as main medicinal materials in the formula. The weight-losing tea has the effects of tonifying qi and nourishing, consolidating the foundation and harmonizing the stomach, avoiding diarrhea and treating both principal and secondary aspects of diseases, and is reasonable in compatibility. The formula has the effects of tonifying spleen and eliminating dampness, ascending the clear and eliminating turbid, and regulating gravity and qi, and regulating multiple internal organs, and is the embodiment of the overall regulating thinking of the traditional Chinese medicine.
Second, the specificity of the dosage
The formula of the invention comprises the following raw materials in parts by weight: 12-24 parts of ginseng, 12-24 parts of lotus leaf, 15-24 parts of poria cocos, 8-12 parts of mulberry, 8-12 parts of lily, 12-18 parts of fingered citron, 8-12 parts of chrysanthemum, 12-18 parts of lophatherum gracile, 12-18 parts of dendrobium officinale, 12-18 parts of hawthorn, 12-18 parts of fried cassia seed, 8-12 parts of lotus seed and 8-12 parts of eucommia leaf.
The monarch drug in the invention is prepared from 12-24 parts of ginseng, 12-24 parts of lotus leaf and 15-24 parts of poria cocos. As recorded in the Fa Xiang of herbs, ren Shen, Fu Ling and Ye can treat insufficiency of yang qi of spleen and lung, and tonify lung, promote qi circulation, shorten qi and reduce qi. The three herbs are combined according to the proportion to tonify and moderate, purge fire evil in spleen, lung and stomach, and treat short breath well. The formula is mainly used for regulating qi activity of a human body, ascending the clear and resolving the turbid, and promoting diuresis and tonifying qi, so that the dosage of the three medicines is properly increased, and the effect of strengthening the foundation while treating obesity is enhanced.
Meanwhile, 8-12 parts of mulberry, 8-12 parts of lily, 12-18 parts of fingered citron, 8-12 parts of chrysanthemum, 12-18 parts of lophatherum gracile, 12-18 parts of dendrobium officinale and 12-18 parts of hawthorn are taken as ministerial medicines. The dosage of the mulberry, the lily and the chrysanthemum is slightly less, and one of the three medicines has the effects of enriching blood, nourishing yin, clearing away heart fire, soothing the nerves, dissipating wind and clearing heat so as to assist weight reduction; and the second time, the taste and the smell are improved. The dosages of the fingered citron, the lophatherum gracile, the dendrobium officinale and the hawthorn are increased compared with the dosages of other ministerial drugs. The medicines enter spleen and stomach meridians, mainly promote diuresis and relieve diarrhea, dry dampness and resolve phlegm, and can help monarch drugs promote diuresis and tonify qi. Modern pharmacological research also shows that the fingered citron has the effect of promoting the secretion of digestive juice; lophatherum gracile has diuretic effect; the dendrobium officinale has a certain promotion effect on gastrointestinal functions; the fructus crataegi has blood lipid reducing effect. Therefore, the medicines are clinically used for a plurality of times, and the weight loss is obvious.
12-18 parts of fried cassia seed, 8-12 parts of lotus seed and 8-12 parts of eucommia leaf, and the three medicines are slightly less than the whole formula. The three herbs are mainly used for strengthening the heart and kidney, tranquilizing the mind and tonifying the kidney, so the dosage is slightly reduced.
Third, the principle of instantaneous differential pressure extraction process
The medicinal raw materials are placed under high saturated vapor pressure for a short time, then the pressure is suddenly reduced to a vacuum state, the plant tissues are continuously contracted and expanded and endowed with a porous structure by continuous pressure reduction and pressure reduction circulation in the extraction process, cells are instantaneously burst by high pressure difference and fully contacted with a solvent, the condition is the primary condition for realizing the extraction rate of more than 95 percent, and the molecular release is facilitated. Before each experiment, firstly removing the air in the whole extraction device to keep a vacuum state, so that the medicinal material and steam have a good mass transfer effect, and secondly performing appropriate pressure and pressure rise circulation operation to extract effective components until the active components of the medicinal material are completely extracted.
The invention has the beneficial effects that: the selected traditional Chinese medicines have simple compatibility and easily obtained sources, and the prepared preparation is convenient to carry. Aiming at the phlegm-damp type obesity patients, the traditional Chinese medicine composition is combined with various traditional Chinese medicine components from the aspects of ascending the clear and resolving the turbid, and tonifying qi and spleen, wherein ginseng, lotus leaves and poria cocos are used as monarch drugs; mulberry, lily, chrysanthemum, fingered citron, lophatherum gracile, dendrobium officinale and hawthorn are used as ministerial drugs; parched semen Cassiae, semen Nelumbinis, and folium Eucommiae as adjuvant drugs. Wherein the ginseng, the tuckahoe and the lotus seed can tonify qi, invigorate spleen, strengthen body resistance and lose weight; semen Cassiae preparata has effects of relaxing bowels and removing food retention, and folium Nelumbinis, Poria and fructus crataegi have effects of eliminating dampness, eliminating phlegm, regulating lipid, eliminating the symptoms and reducing weight; the chrysanthemum is beneficial to restoring liver function and improving abnormal synthesis and metabolism of cholesterol; the eucommia leaves tonify the liver and the kidney and enhance the immunity of the organism; the dendrobium officinale can promote the production of body fluid and nourish yin, and can prevent the heat and yin injury of the obese people with phlegm-dampness, qi stagnation and blood stasis; bulbus Lilii and herba Lophatheri have effects of calming heart, tranquilizing mind, relieving restlessness, and regulating mental anxiety and insomnia. The medicines are compatible and cooperate to generate the effect, and the effects of strengthening spleen, soothing liver, tonifying kidney, calming heart, eliminating dampness and regulating fat are achieved together. The traditional Chinese medicine preparation is particularly suitable for obesity caused by long-term improper diet, work and rest degree and emotional disorder, and has a remarkable curative effect. Has the functions of invigorating spleen and stomach, eliminating dampness and phlegm, loosening bowel to relieve constipation, reducing blood fat and losing weight.
The invention adopts an instantaneous differential pressure extraction process to promote the separation of the active ingredients of the medicinal materials and improve the extraction efficiency, and adopts a near infrared spectrum detection method to judge the decoction endpoint, thereby being convenient to control the decoction extraction quality of the medicinal materials, and preventing the medicinal materials from generating toxicity due to overcooking and scorching or preventing the quality fluctuation of the liquid medicine due to insufficient decoction from influencing the efficacy of the decoction.
Detailed Description
1. Screening of monarch drug active ingredient and related target spot
On the basis of collecting active compounds of ginseng, lotus leaf and tuckahoe in a traditional Chinese medicine database TCMSP (https:// TCMSP-e.com /), chemical components meeting the Oral Bioavailability (OB) of not less than 40% and the drug-like property (DL) of not less than 0.18 are selected as candidate active components (see Table 1). And selecting the species as Homo sapiens by using a UniProt database to obtain 107 pieces of genetic symbol information.
2. Collection of obesity-related targets
Obesity drug action targets were collected from the Genecards (https:// www.genecards.org /) database, for a total of 9489 obesity-related targets.
3. Construction of drug component-target gene-disease network
Introducing the obtained medicine gene symbol and obesity target gene into a Wien diagram on-line tool (https:// bioinfogp. cnb. csic. es/tools/venny/index. html /), obtaining 98 targets related to obesity of ginseng, lotus leaf and tuckahoe components, then introducing the target information and the screened active components and the corresponding relation thereof into Cytoscape 3.7.0, selecting a network topology analysis function visualization analysis result, and obtaining a medicine-component-target-disease network diagram.
PPI network construction
And (3) introducing 98 common targets into a String database for network topology analysis, wherein the database comprises 98 nodes and 927 edges. According to the protein interconnection, it can be seen that IL6 is related to 114 other proteins, and HSP90AA1, CASP3, ESR1, HIF1A, PPARG, EGFR and MYC are related to 112, 104, 102 and 100 other proteins, respectively. Suggesting that these targets may be core targets associated with obesity.
GO enrichment analysis and KEGG pathway enrichment analysis
Studies GO enrichment and KEGG pathway enrichment assays were performed using Bioconductor (R) v3.13 (http:// bioconductor. org /). GO functional enrichment analysis obtains 117 GO entries (P < 0.05), which mainly relate to the processes of nuclear receptor activity, ligand activated transcription factor activity, DNA binding transcription factor binding, RNA polymerase II specific DNA binding transcription factor binding, steroid hormone receptor, ubiquitin-like protein ligase binding, ubiquitin protein ligase binding, steroid binding and DNA binding transcription activation activity, RNA polymerase II specificity, DNA binding transcription activation factor activity, cysteine endopeptidase activity participating in apoptosis signal pathway, transcription co-activation factor binding, transcription co-regulator binding, postsynaptic neurotransmitter receptor activity, cysteine endopeptidase activity participating in apoptosis process, Hsp90 protein binding, activation transcription factor binding, acetylcholine receptor activity, ATPase binding and the like.
Through KEGG gene annotation functional analysis, 98 relevant targets are enriched and mapped to 130 signal pathways, including endocrine resistance, lipid and atherosclerosis, apoptosis, fluid shear stress and atherosclerosis, AGE-RAGE signal pathways in diabetic complications, tumor necrosis factor signal pathways, prostatic cancer, colorectal cancer, proteoglycan in cancer, hepatocellular carcinoma, small cell lung cancer and other pathways.
The analysis of the prediction analysis result of the monarch drug target point shows that: the combination of monarch drugs ginseng, lotus leaf and tuckahoe can effectively regulate and control related passages of obesity, metabolic diseases caused by obesity, inflammation caused by obesity, cancer and other related diseases, and by combining the monarch drugs ginseng, lotus leaf and tuckahoe in the pharmacological formula of the monarch drugs, the monarch drugs ginseng tonifies spleen and benefits lung, greatly supplements primordial qi, lotus leaf lifts clear and dissolves dampness, the three drugs ginseng, lotus leaf and tuckahoe in the pharmacological formula of the monarch drugs can be used together to strengthen spleen and replenish qi, and can also dispel dampness and promote diuresis, relax bowel and relieve constipation without hurting spleen, and the function of regulating and controlling the related passages can be presumed to come from the regulation and control mechanism of the functions of monarch drugs in combination of tonifying qi, promoting diuresis, lifting clear and dissolving turbidity.
The invention designs a traditional Chinese medicine composition for ascending the clear, eliminating the turbid, promoting diuresis, tonifying qi, losing weight and reducing fat by analyzing according to the network pharmacology research result, which comprises the following medicinal materials: ginseng, lotus leaves, poria cocos, mulberries, lilies, fingered citron, chrysanthemum, lophatherum gracile, dendrobium officinale, hawthorn, fried cassia seeds, lotus seeds and eucommia leaves. The technical solutions of the present invention are described below clearly and completely with reference to the following embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments.
Example 1
A traditional Chinese medicine composition for ascending the clear, resolving turbidity, promoting diuresis, benefiting qi, losing weight and reducing fat is prepared from the following medicinal materials in parts by weight: 24 parts of ginseng, 16 parts of lotus leaf, 18 parts of tuckahoe, 10 parts of mulberry, 8 parts of lily and Hunan West, 16 parts of fingered citron, 10 parts of Guangdong chrysanthemum, 16 parts of Anhui bamboo leaf, 16 parts of Anhui dendrobium and dendrobium officinale, 12 parts of Yunnan hawthorn, 15 parts of cassia seed, 8 parts of Anhui lotus seed, 8 parts of Jiangxi eucommia bark leaf and Sichuan also.
The preparation of the traditional Chinese medicine preparation for ascending the clear, resolving the turbid, promoting diuresis, tonifying qi, losing weight and reducing fat comprises the following steps:
s1: preparing medicinal materials: weighing 24 parts of ginseng, 16 parts of lotus leaf, 18 parts of poria cocos, 10 parts of mulberry, 8 parts of lily, 16 parts of fingered citron, 10 parts of chrysanthemum, 16 parts of lophatherum gracile, 16 parts of dendrobium officinale, 12 parts of hawthorn, 15 parts of fried cassia seed, 8 parts of lotus seed and 8 parts of eucommia leaf according to parts by weight, respectively cleaning, cutting, airing at normal temperature, and putting into a wall breaking machine for wall breaking for 10 min.
S2: extraction: adding the mixture of the medicinal materials obtained by breaking the walls in the step S1 into an extraction tank, adding distilled water to submerge all the medicinal materials, adding the distilled water and the medicinal materials with the mass ratio of 5:1, soaking for 3 hours, decocting for 1.5 hours for the first time, and collecting decoction; adding distilled water into the residue after the first decoction, wherein the mass ratio of the added distilled water to the residue is 4:1, decocting for 1h for the second time, and collecting the decoction again; combining the two collected decoctions; in the decocting process, repeatedly pressurizing and depressurizing to form instantaneous pressure difference, pressurizing to 0.5Mpa by a gas booster pump, maintaining the pressure for 180 seconds, then depressurizing by a relief valve, discharging high-pressure steam into a condensation buffer tank for condensation, reserving condensate for later use, vacuumizing an extraction tank to-0.1 Mpa by a vacuum pump to form instantaneous pressure difference to promote the effective components of the medicine to be separated out, and circulating in the way until the extraction is finished.
S3: preparing medicinal powder: filtering the decoction, concentrating the filtrate and condensate under reduced pressure at 50 deg.C under-0.09 Mpa to obtain soft extract with relative density of 1.34 (50 deg.C), and drying under reduced pressure at 60 deg.C under-0.09 Mpa to obtain medicinal powder;
s4: preparation: pulverizing the medicinal powder obtained in step S3, mechanically homogenizing, sieving with 20 mesh sieve, grading, and packaging into 20g medicinal bags or capsule shells to make into capsule.
Example 2
A traditional Chinese medicine composition for ascending the clear, resolving turbidity, promoting diuresis, benefiting qi, losing weight and reducing fat is prepared from the following medicinal materials in parts by weight: 12 parts of ginseng, 20 parts of lotus leaf, 15 parts of tuckahoe, 10 parts of mulberry, 8 parts of lily and Hunan West, 12 parts of fingered citron, 10 parts of Guangdong chrysanthemum, 16 parts of Anhui and lophatherum gracile, 12 parts of Anhui and dendrobium officinale, 12 parts of Yunnan and hawthorn, 18 parts of Shandong and fried cassia seed, 10 parts of Anhui lotus seed, 8 parts of Jiangxi and eucommia bark leaf and Sichuan.
The preparation of the traditional Chinese medicine preparation for ascending the clear, resolving the turbid, promoting diuresis, tonifying qi, losing weight and reducing fat comprises the following steps:
s1: preparing medicinal materials: weighing 12 parts of ginseng, 20 parts of lotus leaf, 15 parts of poria cocos, 10 parts of mulberry, 8 parts of lily, 12 parts of fingered citron, 10 parts of chrysanthemum, 16 parts of lophatherum gracile, 12 parts of dendrobium officinale, 12 parts of hawthorn, 18 parts of fried cassia seed, 10 parts of lotus seed and 8 parts of eucommia leaf according to parts by weight, respectively cleaning, cutting, airing at normal temperature, and putting into a wall breaking machine for wall breaking for 5 min.
S2: extraction: adding the mixture of the medicinal materials obtained by breaking the walls in the step S1 into an extraction tank, adding distilled water to submerge all the medicinal materials, adding the distilled water and the medicinal materials with the mass ratio of 5:1, soaking for 3 hours, decocting for 1.5 hours for the first time, and collecting decoction; adding distilled water into the residue after the first decoction, wherein the mass ratio of the added distilled water to the residue is 4:1, decocting for 1h for the second time, and collecting the decoction again; combining the two collected decoctions; in the decocting process, repeatedly pressurizing and depressurizing to form instantaneous pressure difference, pressurizing to 0.5Mpa by a gas booster pump, maintaining the pressure for 180 seconds, then depressurizing by a relief valve, discharging high-pressure steam into a condensation buffer tank for condensation, reserving condensate for later use, vacuumizing an extraction tank to-0.1 Mpa by a vacuum pump to form instantaneous pressure difference to promote the effective components of the medicine to be separated out, and circulating in the way until the extraction is finished.
S3: preparing medicinal powder: filtering the decoction, concentrating the filtrate and condensate under reduced pressure at-0.09 Mpa and 60 deg.C to obtain soft extract with relative density of 1.4 (60 deg.C), and drying under reduced pressure at-0.09 Mpa and 60 deg.C to obtain medicinal powder;
s4: preparation: pulverizing the medicinal powder obtained in step S3, mechanically homogenizing, sieving with 20 mesh sieve, grading, and packaging into 10g medicinal bags or capsule shells to make into capsule.
Example 3
A traditional Chinese medicine composition for ascending the clear, resolving turbidity, promoting diuresis, benefiting qi, losing weight and reducing fat is prepared from the following medicinal materials in parts by weight: 20 parts of ginseng, 24 parts of lotus leaf, 16 parts of tuckahoe, 8 parts of mulberry, 12 parts of Anhui and lily, 12 parts of Hunan West and fingered citron, 8 parts of Guangdong and chrysanthemum, 12 parts of Anhui and lophatherum gracile, 12 parts of Anhui and dendrobium officinale, 12 parts of Yunnan and hawthorn, 15 parts of Shandong and fried cassia seed, 12 parts of Anhui and lotus seed, 10 parts of Jiangxi and eucommia leaf and Sichuan.
The preparation of the traditional Chinese medicine preparation for ascending the clear, resolving the turbid, promoting diuresis, tonifying qi, losing weight and reducing fat comprises the following steps:
s1: preparing medicinal materials: weighing 20 parts of ginseng, 24 parts of lotus leaf, 16 parts of poria cocos, 8 parts of mulberry, 12 parts of lily, 12 parts of fingered citron, 8 parts of chrysanthemum, 12 parts of lophatherum gracile, 12 parts of dendrobium officinale, 12 parts of hawthorn, 15 parts of fried cassia seed, 12 parts of lotus seed and 10 parts of eucommia leaf according to parts by weight, respectively cleaning, cutting, airing at normal temperature, and putting into a wall breaking machine for wall breaking for 15 min.
S2: extraction: adding the mixture of the medicinal materials obtained by breaking the walls in the step S1 into an extraction tank, adding distilled water to submerge all the medicinal materials, adding the distilled water and the medicinal materials with the mass ratio of 6:1, soaking for 2 hours, decocting for 1 hour for the first time, and collecting decoction; adding distilled water into the residue after the first decoction, wherein the mass ratio of the added distilled water to the residue is 3:1, decocting for 1h for the second time, and collecting the decoction again; combining the two collected decoctions; in the decocting process, repeatedly pressurizing and depressurizing to form instantaneous pressure difference, pressurizing to 0.3Mpa by a gas booster pump, maintaining the pressure for 120 seconds, then decompressing by a pressure relief valve, discharging high-pressure steam into a condensation buffer tank for condensation, reserving condensate for later use, vacuumizing to-0.1 Mpa by a vacuum pump extraction tank to form instantaneous pressure difference to promote the effective components of the medicine to be separated out, and circulating in the way until the extraction is finished.
S3: preparing medicinal powder: filtering the decoction, wherein the aperture of the microfiltration membrane is 1 μm, concentrating the filtrate and condensate under reduced pressure at-0.09 Mpa and 40 deg.C to obtain soft extract with relative density of 1.30 (40 deg.C), and drying under reduced pressure at-0.09 Mpa and 60 deg.C to obtain medicinal powder;
s4: preparation: pulverizing the medicinal powder obtained in step S3, mechanically homogenizing, sieving with 20 mesh sieve, grading, and packaging into 30g medicinal bags or capsule shells to make into capsule.
Example 4
A traditional Chinese medicine composition for ascending the clear, resolving turbidity, promoting diuresis, benefiting qi, losing weight and reducing fat is prepared from the following medicinal materials in parts by weight: 16 parts of ginseng, 20 parts of lotus leaf, 20 parts of Jiangxi, 20 parts of tuckahoe, 12 parts of Yunnan, mulberry, 12 parts of Anhui and lily, 12 parts of Hunan West and fingered citron, 10 parts of Guangdong and chrysanthemum, 18 parts of Anhui and lophatherum gracile, 12 parts of Anhui and dendrobium officinale, 14 parts of Yunnan and hawthorn, 12 parts of Shandong and fried cassia seed, 12 parts of Anhui and lotus seed, 8 parts of Jiangxi and eucommia leaf and Sichuan.
The preparation of the traditional Chinese medicine preparation for ascending the clear, resolving the turbid, promoting diuresis, tonifying qi, losing weight and reducing fat comprises the following steps:
s1: preparing medicinal materials: weighing 16 parts of ginseng, 20 parts of lotus leaf, 20 parts of poria cocos, 12 parts of mulberry, 12 parts of lily, 12 parts of fingered citron, 10 parts of chrysanthemum, 18 parts of lophatherum gracile, 12 parts of dendrobium officinale, 14 parts of hawthorn, 12 parts of fried cassia seed, 12 parts of lotus seed and 8 parts of eucommia leaf according to parts by weight, respectively cleaning, cutting, airing at normal temperature, and putting into a wall breaking machine for wall breaking for 10 min.
S2: extraction: adding the medicinal material mixture obtained by breaking the walls in the step S1 into an extraction tank, adding distilled water to submerge all the medicinal materials, adding distilled water and the medicinal materials with a mass ratio of 5:1, soaking for 3h, carrying out first decoction, taking decoction for near infrared spectrum and medicinal material content determination during first decoction, establishing a near infrared spectrum and medicinal material content correlation model, determining the end point of decoction in the subsequent decoction process according to the near infrared spectrum determined by an online near infrared spectrum detection device, repeatedly pressurizing and depressurizing to form instantaneous pressure difference in the decoction process, pressurizing to 0.2MPa by a gas booster pump, maintaining the pressure for 60 seconds, then depressurizing by a relief valve, discharging high-pressure steam into a condensation buffer tank for condensation, reserving condensate, vacuumizing the extraction tank to-0.1 MPa by a vacuum pump to form the instantaneous pressure difference to promote the effective components of the medicines to be separated out, and circulating in such a manner until the extraction is finished, collecting decoction; adding distilled water into the dregs obtained after the first decoction, wherein the mass ratio of the distilled water to the dregs is 4:1, carrying out the second decoction, carrying out near infrared spectrum and medicinal material content measurement on the decoction, establishing a near infrared spectrum and medicinal material content correlation model, determining a decoction endpoint according to the near infrared spectrum measured by an online near infrared spectrum detection device in the subsequent batch of decoction, repeatedly pressurizing and depressurizing the decoction again in the second decoction to form instantaneous pressure difference, and collecting the decoction again; combining the two collected decoctions;
s3: preparing medicinal powder: filtering the decoction, concentrating the filtrate under reduced pressure at 50 deg.C under-0.09 Mpa to obtain soft extract with relative density of 1.34 (50 deg.C), and drying the soft extract under reduced pressure at 60 deg.C under-0.09 Mpa to obtain medicinal powder;
s4: preparation: pulverizing the medicinal powder obtained in step S3, mechanically homogenizing, sieving with 20 mesh sieve, grading, and packaging into 20g medicinal bags or capsule shells to make into capsule.
Example 5
A traditional Chinese medicine composition for ascending the clear, resolving turbidity, promoting diuresis, benefiting qi, losing weight and reducing fat is prepared from the following medicinal materials in parts by weight: 14 parts of ginseng, 18 parts of lotus leaf, 20 parts of tuckahoe, 8 parts of mulberry, 10 parts of Anhui lily, 15 parts of Hunan West and fingered citron, 12 parts of Guangdong chrysanthemum, 12 parts of Anhui bamboo leaf, 18 parts of Anhui dendrobium, 16 parts of Yunnan and hawthorn, 12 parts of Shandong cassia seed, 8 parts of Anhui lotus seed, 12 parts of Jiangxi eucommia bark leaf and Sichuan Si.
The preparation of the traditional Chinese medicine preparation for ascending the clear, resolving the turbid, promoting diuresis, tonifying qi, losing weight and reducing fat comprises the following steps:
s1: preparing medicinal materials: 14 parts of ginseng, 18 parts of lotus leaf, 18 parts of Jiangxi, 20 parts of tuckahoe, 8 parts of mulberry, 10 parts of Anhui and lily, 15 parts of Hunan West and fingered citron, 12 parts of Guangdong and chrysanthemum, 12 parts of Anhui and lophatherum gracile, 18 parts of Anhui and dendrobium officinale, 16 parts of Yunnan and hawthorn, 12 parts of Shandong and fried cassia seed, 8 parts of Anhui and lotus seed, 12 parts of Jiangxi and eucommia leaf and Sichuan are respectively cleaned, cut off and dried at normal temperature, and are put into a machine together for wall breaking treatment for 10 min.
S2: extraction: adding the mixture of the medicinal materials obtained by breaking the wall in the step S1 into an extraction tank, adding distilled water to submerge all the medicinal materials, adding the distilled water and the medicinal materials with the mass ratio of 5:1, soaking for 3h, decocting for the first time, when decocting the first time, collecting decoction, performing near infrared spectrum and medicinal material content measurement, establishing a near infrared spectrum and medicinal material content correlation model, in the subsequent batch decocting process, the terminal point of the decoction is judged according to the near infrared spectrum detected by the on-line near infrared spectrum detection device, repeatedly pressurizing and depressurizing to form instantaneous pressure difference, pressurizing to 0.5Mpa by a gas booster pump, maintaining the pressure for 30 seconds, then the pressure is released by a pressure release valve, high-pressure steam is discharged into a condensation buffer tank for condensation, condensate is reserved, and vacuumizing the extraction tank to-0.1 Mpa by a vacuum pump to form instantaneous pressure difference to promote the effective components of the medicine to be separated out, circulating the steps until the extraction is finished, and collecting decoction; adding distilled water into the dregs obtained after the first decoction, wherein the mass ratio of the added distilled water to the dregs is 4:1, carrying out the second decoction, taking decoction, carrying out near infrared spectrum and medicinal material content measurement, establishing a near infrared spectrum and medicinal material content correlation relationship, determining a decoction endpoint according to the near infrared spectrum measured by an online near infrared spectrum detection device in the subsequent batch of decoction, repeatedly pressurizing and depressurizing in the second decoction to form instantaneous pressure difference, and collecting decoction again; combining the two collected decoctions;
s3: preparing medicinal powder: filtering the decoction, concentrating the filtrate under reduced pressure at 50 deg.C under-0.09 Mpa to obtain soft extract with relative density of 1.40 (50 deg.C), and drying the soft extract under reduced pressure at 60 deg.C under-0.09 Mpa to obtain medicinal powder;
s4: preparation: pulverizing the medicinal powder obtained in step S3, mechanically homogenizing, sieving with 20 mesh sieve, grading, and packaging into 20g medicinal bags or capsule shells to make into capsule.
Example 6
A traditional Chinese medicine composition for ascending the clear, resolving turbidity, promoting diuresis, benefiting qi, losing weight and reducing fat is prepared from the following medicinal materials in parts by weight: 12 parts of ginseng, 16 parts of lotus leaf, 24 parts of tuckahoe, 8 parts of mulberry, 10 parts of Anhui lily, 18 parts of Hunan West and fingered citron, 10 parts of Guangdong chrysanthemum, 14 parts of Anhui bamboo leaf, 16 parts of Anhui dendrobium and dendrobium officinale, 18 parts of Yunnan and hawthorn, 12 parts of Shandong and fried cassia seed, 8 parts of Anhui lotus seed, 12 parts of Jiangxi and eucommia leaf and four Sichuan.
The preparation of the traditional Chinese medicine preparation for ascending the clear, resolving the turbid, promoting diuresis, tonifying qi, losing weight and reducing fat comprises the following steps:
s1: preparing medicinal materials: according to the weight portion, 12 portions of ginseng, 16 portions of lotus leaf, 24 portions of tuckahoe, 8 portions of Yunnan and mulberry, 10 portions of lily and Anhui, 18 portions of fingered citron, 10 portions of Guangdong and chrysanthemum, 14 portions of Anhui and lophatherum gracile, 16 portions of Anhui and dendrobium officinale, 18 portions of Yunnan and hawthorn, 12 portions of Shandong and fried cassia seed, 8 portions of Anhui and lotus seed, 12 portions of Jiangxi and eucommia bark leaf and Sichuan are respectively cleaned, cut off and dried at normal temperature, and are put into a wall breaking machine together for wall breaking treatment for 10 min.
S2: extraction: adding the mixture of the medicinal materials obtained by breaking the wall in the step S1 into an extraction tank, adding distilled water to submerge all the medicinal materials, adding the distilled water and the medicinal materials with the mass ratio of 5:1, soaking for 3h, decocting for the first time, when decocting the first time, collecting decoction, performing near infrared spectrum and medicinal material content measurement, establishing a near infrared spectrum and medicinal material content correlation model, in the subsequent batch decocting process, the terminal point of the decoction is judged according to the near infrared spectrum detected by the on-line near infrared spectrum detection device, repeatedly pressurizing and depressurizing to form instantaneous pressure difference, pressurizing to 0.1Mpa by a gas booster pump, maintaining the pressure for 180 seconds, then the pressure is released by a pressure release valve, high-pressure steam is discharged into a condensation buffer tank for condensation, condensate is reserved, and vacuumizing the extraction tank to-0.1 Mpa by a vacuum pump to form instantaneous pressure difference to promote the effective components of the medicine to be separated out, circulating the steps until the extraction is finished, and collecting decoction; adding distilled water into the dregs obtained after the first decoction, wherein the mass ratio of the distilled water to the dregs is 4:1, carrying out the second decoction, carrying out near infrared spectrum and medicinal material content measurement on the decoction, establishing a near infrared spectrum and medicinal material content correlation model, determining a decoction endpoint according to the near infrared spectrum measured by an online near infrared spectrum detection device in the subsequent batch of decoction, repeatedly pressurizing and depressurizing the decoction again in the second decoction to form instantaneous pressure difference, and collecting the decoction again; combining the two collected decoctions;
s3: preparing medicinal powder: filtering the decoction, concentrating the filtrate under reduced pressure at 50 deg.C under-0.09 Mpa to obtain soft extract with relative density of 1.36 (50 deg.C), and drying the soft extract under reduced pressure at 60 deg.C under-0.09 Mpa to obtain medicinal powder;
s4: preparation: pulverizing the medicinal powder obtained in step S3, mechanically homogenizing, sieving with 20 mesh sieve, grading, and packaging into 20g medicinal bags or capsule shells to make into capsule.
1. Clinical data
1.1 sources of cases
120 simple obese people who are hospitalized in the hospital from 1 month in 2020 to 1 month in 2021 are selected.
1.2 diagnostic criteria
Refer to the "guidelines for preventing and controlling overweight and obesity of Chinese adults" issued by department of health, China department of health in 4 months in 2003 and the "guidelines for diagnosing and treating obesity at the primary level of Chinese medical society in 2019: adult 24.0 kg/m2≤BMI＜28.0 kg/m2Is overweight, not less than 28.0 kg/m2Is obese; central obesity can be determined by waist circumference: the waist of the male is 85-90 cm, the waist of the female is 80-85 cm, the waist of the male is more than or equal to 90cm, and the waist of the female is more than or equal to 85cm, the male is central obesity.
1.3 case selection
1.3.1 case inclusion criteria
(1) The diagnosis standard of simple obesity in western medicine is met;
(2) the diagnosis standard of the traditional Chinese medicine obesity is met;
(3) the compliance is good, the treatment and the nursing are matched, and no special dietary addiction exists;
(4) no other weight loss treatments were received within the last 3 months;
(5) the age is 18-60 years;
(6) clear consciousness, sign related informed consent, voluntarily enter the team.
1.3.2 case exclusion criteria
(1) Non-compliance with diagnostic criteria, secondary obesity due to other causes: hyperthyroidism, hypothyroidism, pituitary diseases, hypogonadism, drug-induced obesity, etc.;
(2) patients with severe visceral diseases such as heart, liver and kidney or blood system diseases;
(3) those under 18 years of age or over 60 years of age;
(4) those who have been allergic to a variety of traditional Chinese medicines or are known to be susceptible to allergy;
(5) poor compliance, inability to adhere to treatment or to coordinate treatment and follow-up;
(6) those with mental or intellectual disabilities who are not matched;
(7) pregnant and lactating women.
1.3.3 case knockout criteria
(1) Those who withdraw from the treatment process;
(2) calculating adverse reaction statistics for the patients with adverse reaction in the research;
(3) if the patients do not take the medicine according to the requirements, the results are biased;
(4) during the treatment process, other diseases are caused, and the investigators need to be stopped;
(5) those who are lost of visit.
2. Research method
2.1 grouping method
120 patients meeting the inclusion criteria were grouped according to the random number table method, and were divided into 2 groups on average, of which 60 patients in the treatment group and 60 patients in the control group.
2.2 test methods
(1) The patient is signed with a treatment informed consent before treatment, and the patient is subjected to healthy propaganda and education of obesity, so that the cognition of the patient on the obesity, which is an important risk factor causing various diseases, is deepened, the patient is informed of the help of a scientific life style on the prevention and treatment of the obesity, the concept that the patient takes medicines according to the advice of a doctor is strengthened, and the treatment compliance is improved.
(2) Method of treatment
General treatment: diet, exercise, and psychological guidance were given to both groups. All patients calculated basal metabolism according to body weight, daily activities, and the like, and managed diet and exercise according to the basal metabolism.
Treatment groups: 12-24 parts of ginseng, 12-24 parts of lotus leaf, 15-24 parts of poria cocos, 8-12 parts of mulberry, 8-12 parts of lily, 12-18 parts of fingered citron, 8-12 parts of chrysanthemum, 12-18 parts of lophatherum gracile, 12-18 parts of dendrobium officinale, 12-18 parts of hawthorn, 12-18 parts of fried cassia seed, 8-12 parts of lotus seed and 8-12 parts of folium cortex eucommiae are treated according to dialectical theory, the qi deficiency and phlegm dampness are obvious, and the amount of ginseng and poria cocos is large; the qi movement is not smooth, and the lotus leaf amount is large; the amount of lily, chrysanthemum, folium cortex eucommiae and mulberry is large when the lung, kidney and liver are regulated; the amount of fingered citron, hawthorn, dendrobium officinale and lotus seeds which are involved in spleen and stomach disharmony is large; for constipation, the amount of parched semen Cassiae is large; for restlessness due to deficiency and insomnia, the usage amount of lophatherum gracile is large.
One dose is taken every day, warm taken in the morning and evening after meals.
Control group: metformin hydrochloride tablet (Shanghai Shi Guibao pharmacy Co., Ltd., China American, approval No.: national standard character H20023370, specification: 0.5 g/tablet x20 tablet) is orally administered 1 time 0.5g 3 times a day in meals.
The treatment period of the treatment group and the control group is 2 months.
2.3 Observation of therapeutic Effect
2.3.1 body weight, body Mass index observations
Recording the height and weight of the patient before and after treatment, calculating the body mass index BMI = weight (kg)/(height (m))2。
2.3.2 waistline Observation
Measuring Waist Circumference (WC) of the patient before and after treatment, method: the subject takes the vertical position and measures the circumferential length of the body at the horizontal position of the lower edge of the costal arch of the axillary midline and the midpoint of the connecting line of the iliac spines.
2.3.3 lipid indicator observations
Detecting blood lipid of patients before and after treatment, and observing the change of Total Cholesterol (TC), Triglyceride (TG), low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C) index.
2.3.4 safety index observations
The method comprises the following steps of: observing general vital signs of blood pressure, respiration, pulse, heart rate and the like of a patient before and after taking the medicine;
routine blood and urine, electrocardiogram, liver function, kidney function and other general auxiliary tests; ③ adverse events (detailed record at any time).
2.4 determination of therapeutic Effect on obesity
(1) And (3) healing: the body weight reaches the standard body weight range, and the Body Mass Index (BMI) is less than 24kg/m2；
(2) The effect is shown: the weight of the patient is reduced by more than 5kg (including 5 kg), and the Body Mass Index (BMI) is reduced by more than or equal to 4kg/m2；
(3) The method has the following advantages: the weight is reduced by 2-5 kg (containing 2kg), the BMI is reduced by 2-less than 4kg/m2；
(4) And (4) invalidation: body weight is not reduced or reduced by less than 2kg, BMI is reduced by less than 2kg/m2。
Total effective rate = (number of effective cases + number of effective cases)/total number of cases x 100%.
2.5 Security determination
Level 1: the patient has no adverse reaction, and the detection index has no abnormal change.
And 2, stage: the patient has mild adverse reaction, but can tolerate the drug without stopping the drug treatment.
And 3, level: the patients have obvious adverse reactions, the adverse reactions need to be treated symptomatically, and the drug tests and treatments can be continued after the treatment.
4, level: the patients have obvious adverse reactions and cannot tolerate the drug treatment, and the test needs to be stopped.
3. Statistical method
Statistical processing is carried out by using SPSS 26.0 software, and the measured data are calculated by mean +/-standard deviation
The comparison between the front and the back is performed by adopting a matched sample t test, the counting data is compared by adopting a chi-square test and a rank sum test, the difference of the experimental results of the two samples has statistical significance when P is less than 0.05, and the difference has significant statistical significance when P is less than 0.01.
4. Results of the study
4.1 gender and age
Treatment groups 23 men and 37 women; the control group had 26 men and 34 women. The counting data chi-square test analysis is applied, P is more than 0.05, no statistical significance is suggested, and the two groups have comparability.
The mean age of the treated group was 37.45 ± 10.63 years, and the mean age of the control group was 37.08 ± 10.71 years. Independent sample t test analysis shows that P is greater than 0.05, suggesting that the difference is not statistically significant, and the two groups are comparable and detailed in Table 2.
4.2 analysis of the body weight, body mass index and waist circumference treatment effect of two groups of patients
4.2.1 comparison of body weight, body Mass index and waist circumference of the two groups before treatment
Before treatment, the body weights, Body Mass Index (BMI) and Waist Circumference (WC) of two groups of patients were analyzed by independent sample t test, and P was greater than 0.05, indicating that the difference was not statistically significant, and that the two groups were comparable, as detailed in Table 3.
4.2.2 comparison of body weight, body Mass index, waist circumference before and after treatment of patients in the treatment group
After treatment, the body weight, BMI and WC of patients are reduced compared with those before treatment, and the P is less than 0.01 after the analysis of matched t test, which indicates that the difference is significant, and shows that the traditional Chinese medicine formula can reduce the body weight, body mass index and waist circumference of obese patients, and the detailed table is shown in Table 4.
4.2.3 comparison of body weight, body mass index, waist circumference before and after treatment in control patients
After the control group is treated, the body weight, BMI and WC of the patients are reduced compared with those before the treatment, and the P is less than 0.01 by the analysis of the matched t test, which indicates that the difference is significant, and the weight, body mass index and waist circumference of the obese patients can also be reduced by the metformin, which is detailed in Table 5.
4.2.4 comparison of body weight, body mass index, waist reduction after treatment in the two groups
The weight, body mass index and waist reduction after treatment of the two groups are compared between the groups, and the P is less than 0.01 after t-test analysis of independent samples, so that the prompt difference is significant, the reduction mean value of the treatment group is greater than that of the control group, and the curative effect of the treatment group is better than that of the control group, as shown in table 6.
4.3 analysis of blood lipid treatment effects of two groups of patients
4.3.1 comparison of blood lipid indicators before and after treatment of two groups of patients
Comparing the blood lipid indexes (TC, TG and LDL-C, HDL-C) of the two groups before treatment, P is greater than 0.05, which indicates that the difference is not statistically significant, and the two groups have comparability.
Compared with the blood lipid indexes (TC, TG and LDL-C, HDL-C) before and after treatment in a treatment group, P is less than 0.01, and the prompt difference has significance, which indicates that the traditional Chinese medicine formula disclosed by the invention has an obvious improvement effect on TC, TG and LDL-C, HDL-C.
The blood lipid indexes before and after treatment of the control group are compared, and P is less than 0.01 before and after treatment of TC, TG and LDL-C, so that the prompt difference has statistical significance, which indicates that the control group has obvious improvement on TC, TG and LDL-C; comparison before and after HDL-C treatment revealed that P was > 0.05 and was not statistically significant, as shown in Table 7.
Note: represents P <0.05 compared with the same group before treatment
4.3.2 comparison of the difference between the two groups of patients before and after blood lipid treatment
The blood lipid difference values before and after treatment of the two groups are compared, and independent t test shows that the comparison P of the TC difference value and the HDL-C difference value is less than 0.05, the difference has statistical significance, and the improvement effect of the treatment group on the TC and the HDL-C is more obvious than that of a control group; the comparison of the TG difference and LDL-C difference, P > 0.05, was statistically insignificant, as shown in Table 8.
Note: delta denotes P <0.05 in comparison with the control group
4.4 comparison of therapeutic effects of the two groups
The two groups of medicines have curative effects on obesity, the difference has statistical significance after the rank sum test that P =0.02 and is less than 0.05, and the total effective rate of a treatment group is obviously superior to that of a control group by 93.3 percent, which is shown in Table 9.
Note: delta denotes P <0.05 in comparison with the control group
4.5 two sets of safety comparisons
By observing that 3 patients in the treatment group have slight diarrhea in the process of taking the medicine, but the symptom is relieved and disappears after several days; in contrast, in the control group, 1 patient suffered from nausea, 2 patients suffered from mild diarrhea, and 2 patients suffered from abdominal distension, and the symptoms were relieved after symptomatic treatment. Statistics show that the adverse reaction rate of the treatment group is lower than that of the control group, but the P is more than 0.05 through the test, and the conclusion is not statistically significant. See table 10.
5. Typical case
Case one
Wu somewhere, female, 38 years old, West lake region of Nanchang city.
The patient is fat for more than 6 years, has full abdomen after two fetuses before 6 years, has tried to reduce weight by diet, but the effect is not ideal, and has no consistent movement for various reasons, nearly 1 year with listlessness and hypodynamia, especially after meals, dry mouth, phlegm at the throat in the morning, good diet and sleep, 1-2 rows of excrement every day, thin quality and even urine. Pale-red tongue with white and thick coating, weak pulse and slippery right guan. The weight of the patient was 81kg, the height was 1.6m, and the waist circumference was 94 cm. The past history is not special, and the mother has hypertension.
And (3) Western diagnosis: simple obesity
Traditional Chinese medicine diagnosis: obesity
The treatment method comprises the following steps: order the patient to eat light and low-fat food, and avoid spicy, greasy and high-sugar foods as much as possible. More exercise, less and longer sitting, 3-5 moderate exercises 30min per week. One dose of the traditional Chinese medicine is taken every day.
And B, diagnosis: after 4 weeks of administration, the Chinese medicinal composition is refreshing, has reduced asthenia, and can be used for treating listlessness after meals, dry mouth, defecation 1 time, occasional diarrhea, and most of time for shaping. The body weight is reduced by 1.5 Kg to 79.5Kg, and the waist circumference is reduced by 2cm to 92 cm. The traditional Chinese medicine prescription is continuously taken.
Three diagnoses: after taking for 4 weeks, fatigue, weakness, constipation, thin and white tongue coating, deep pulse and palpation of the index finger are all the more. The weight of the patient is reduced by 2Kg to 77.5 Kg, the waist circumference is reduced by 3 cm, and the waist circumference is reduced to 89 cm. The current diet and exercise scheme is kept continuously, no heavy diet or heavy food is needed, and the medicine of the scheme can be continuously taken to follow up the curative effect.
Case two
Liu certain, female, 33 years old, an Yi county in Nanchang City.
In more than ten years of obesity, patients are happy with high-calorie foods such as sweetmeats and barbecue, and the method for losing weight by medicines and replacing meals is not good in effect. The symptoms of obesity, strong appetite, abdominal distension, thirst with desire for drink, good sleep, dry stool, 1 time per day and even urine. The tongue is red, the coating is thin and yellow, and the pulse is smooth and rapid. The weight was measured at 78kg, the height at 1.65m, and the waist circumference at 88 cm. The past history and family history are not special.
And (3) Western diagnosis: simple obesity
Traditional Chinese medicine diagnosis: obesity
The treatment method comprises the following steps: patients are advised to adjust the dietary structure, reduce the intake of food with high content of saturated fat such as animal internal organs and fat meat, increase the intake of food with high content of fiber such as vegetables, fruits and beans, and reduce the intake of sugar such as desserts and milk tea. Increase exercise and keep 3 moderate exercises for 30min each week. One dose of the traditional Chinese medicine is taken every day.
And B, diagnosis: when the patient takes the medicine for the first time, the stool is increased and thin, the stool is normal after three days, the stool is soft after one month, the patient feels spiritual once a day, the thirst is relieved, the abdomen still has occasionally swelling feeling, the tongue is light red, the tongue coating is thin and white, and the pulse is smooth. The body weight is reduced by 2Kg to 80Kg, the waist circumference is reduced by 1 cm to 87 cm. The traditional Chinese medicine prescription is continuously taken.
Three diagnoses: after taking for another 1 month, no obvious discomfort, mild stool and urine, pale red tongue with thin and white coating and smooth pulse. The weight of the patient is reduced by 2Kg to 78Kg, and the waist circumference is reduced by 2cm to 85 cm. The current diet and exercise scheme is kept continuously, no heavy diet or heavy food is needed, and the medicine of the scheme can be continuously taken to follow up the curative effect.
Case three
Somebody of Cao, man, 52 years old, east lake region of Nanchang city.
The patient is obese for 15 years, has no medicine for taking, and has no need of taking medicine, and has no need of taking business, drinking alcohol and smoking, and hyperlipemia for 5 years. Weight reduction is required because of the fear of cardiovascular and cerebrovascular diseases caused by obesity. The symptoms of the patient are marked by obesity, easy sweating, chest distress, abdominal distension, loose stool for 2 to 3 times every day and nocturia for 1 to 2 times. Pale and swollen with white, thick and greasy coating and thready and slippery pulse. The weight was measured to be 95kg, the height 1.73m, and the waist circumference 104 cm. Father has a history of stroke and mother has hypertension.
And (3) Western diagnosis: simple obesity
Traditional Chinese medicine diagnosis: obesity
The treatment method comprises the following steps: order patients to eat light low-fat diet, avoid food such as spicy, greasy and high sugar content, stop smoking and limit drinking, make regular work and rest, and increase aerobic exercise. One dose of the traditional Chinese medicine is taken every day.
And B, diagnosis: after one month of administration, the symptoms of chest distress, spontaneous perspiration and loose stool still occur, and the symptoms of abdominal distention, pale and swollen tongue, white and slightly greasy coating and slippery pulse occur after the administration once a day. The body weight is reduced by 1.8Kg to 93.2Kg, and the waist circumference is reduced by 2cm to 102 cm. The traditional Chinese medicine prescription is continuously taken.
Three diagnoses: after taking the medicine for 1 month, no abdominal distension, occasional loose stool, flat urine, appetite and sleep, pale red tongue, thin and white fur and smooth pulse are diagnosed. The weight of the patient is reduced by 2.5Kg to 90.7Kg, the waist circumference is reduced by 3 cm, and the waist circumference is reduced to 99 cm. The current diet and exercise scheme is continuously maintained, no heavy diet or overeating occurs, the patient regularly works and stops, and the medicine of the scheme can be continuously taken to follow up the curative effect.
Case four
Zhongjiang, male, 22 years old, Nanchang county, Nanchang City.
The patients are overweight in 8 years, and like to eat fried chicken cola, barbecue buffet and the like after the adolescent period. The symptoms of the disease include tiredness of limbs, especially afternoon, dizziness, abdominal distension, sticky stool, uncomfortable defecation and flat urine. Pale and swollen with white and slippery coating and slippery pulse. The weight was measured at 78kg, the height at 1.70m, and the waist circumference at 90 cm. The past history and family history are not special.
And (3) Western diagnosis: simple obesity
Traditional Chinese medicine diagnosis: obesity
The treatment method comprises the following steps: order patients to reduce the intake of foods with high fat content such as animal internal organs, reduce the intake of high-sugar foods such as cola and milk tea, and increase the intake of foods with high fiber content such as vegetables and fruits. Increasing exercise, and keeping 30min each day. One dose of the traditional Chinese medicine is taken every day.
And B, diagnosis: after being taken for one month, the medicine is still in mind, the afternoon sleepiness is relieved, the head is not dizzy, the stool is taken once a day, the tongue is pale red, the coating is white, and the pulse is smooth. The body weight is reduced by 2.5Kg to 75.5Kg, and the waist circumference is reduced by 1 cm to 89 cm. The traditional Chinese medicine prescription is continuously taken.
Three diagnoses: after taking for another 1 month, no obvious discomfort, mild stool and urine, pale red tongue with thin and white coating and smooth pulse. The weight of the patient is reduced by 3Kg to 72.5Kg, and the waist circumference is reduced by 2cm to 87 cm. The current diet and exercise scheme is kept continuously, no heavy diet or heavy food is needed, and the medicine of the scheme can be continuously taken to follow up the curative effect.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
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