CN113996448B - A kind of hyaluronic acid dressing centrifugal purification device and using method - Google Patents
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Abstract
本发明提供一种透明质酸敷料离心提纯装置及使用方法,该装置包括离心机构、驱动机构、锁止机构、支撑机构和支撑托盘;锁止机构用于驱动离心机构转动;离心机构用于对不同离心程度的透明质酸敷料离心提纯;支撑机构用于对离心筒上下支撑移动,解决了过去的透明质酸敷料不能够根据离心程度的需要进行分级提纯,离心后的透明质酸敷料导出过程复杂的问题,本发明结构合理,采用全新的分级离心筒,根据不同半径的离心筒调试出合适离心程度的透明质酸敷料,可快速分离出不同离心程度的透明质酸敷料,另外本发明的装置省去了复杂的导料组件,方便透明质酸敷料的导出,使用方便高效。
The present invention provides a hyaluronic acid dressing centrifugal purification device and its use method. The device includes a centrifugal mechanism, a driving mechanism, a locking mechanism, a supporting mechanism and a supporting tray; the locking mechanism is used to drive the centrifugal mechanism to rotate; the centrifugal mechanism is used to Centrifugal purification of hyaluronic acid dressings with different degrees of centrifugation; the support mechanism is used to support and move the centrifuge cylinder up and down, which solves the problem that hyaluronic acid dressings in the past cannot be graded and purified according to the degree of centrifugation, and the export process of hyaluronic acid dressings after centrifugation Complicated problems, the present invention has a reasonable structure, adopts a brand-new grading centrifuge cylinder, adjusts hyaluronic acid dressings with appropriate centrifugal degrees according to centrifugal cylinders with different radii, and can quickly separate hyaluronic acid dressings with different centrifugal degrees. In addition, the present invention The device eliminates complicated material guide components, facilitates the export of the hyaluronic acid dressing, and is convenient and efficient to use.
Description
技术领域technical field
本发明是一种透明质酸敷料离心提纯装置及使用方法,涉及透明质酸敷料离心提纯领域。The invention relates to a hyaluronic acid dressing centrifugal purification device and a use method thereof, and relates to the field of hyaluronic acid dressing centrifugal purification.
背景技术Background technique
透明质酸,又称玻尿酸,是D-葡萄糖醛酸及N-乙酰葡糖胺组成的双糖单位糖胺聚糖。透明质酸是一种酸性粘多糖,1934年美国哥伦比亚大学眼科教授Meyer等首先从牛眼玻璃体中分离出该物质。透明质酸具有较高临床价值的生化药物,广泛应用于各类眼科手术,如晶体植入、角膜移植和抗青光眼手术等。还可用于治疗关节炎和加速伤口愈合。将其用于化妆品中,能起到独特的保护皮肤作用,可保持皮肤滋润光滑、细腻柔嫩、富有弹性,具有防皱、抗皱、美容保健和恢复皮肤生理功能的作用。Hyaluronic acid, also known as hyaluronic acid, is a disaccharide unit glycosaminoglycan composed of D-glucuronic acid and N-acetylglucosamine. Hyaluronic acid is an acidic mucopolysaccharide. In 1934, Meyer, a professor of ophthalmology at Columbia University in the United States, first isolated the substance from the bovine vitreous. Hyaluronic acid is a biochemical drug with high clinical value, and is widely used in various ophthalmic operations, such as lens implantation, corneal transplantation and anti-glaucoma surgery. It is also used to treat arthritis and accelerate wound healing. Used in cosmetics, it can play a unique role in protecting the skin. It can keep the skin moist, smooth, delicate, soft and elastic. It has the functions of anti-wrinkle, anti-wrinkle, beauty care and restoration of skin physiological functions.
透明质酸的提炼的方法有三种:There are three methods of refining hyaluronic acid:
1、动物组织:主要原料是鸡冠和牛眼玻璃体等。用丙酮或乙醇将原料脱脂、脱水,用蒸馏水浸泡、过滤,然后以氯化钠水溶液和氯仿溶液处理,之后加入胰蛋白酶保温后得到混合液,最后用离子交换剂进行处理、纯化得到精制的透明质酸。这种方法提取率极低,仅1%左右,分离过程复杂,致使透明质酸价格昂贵,达5000美元/公斤,限制了在化妆品中大的量使用。1. Animal tissue: the main raw materials are cockscomb and vitreous body of bull's eye. Degrease and dehydrate the raw material with acetone or ethanol, soak in distilled water, filter, then treat with sodium chloride aqueous solution and chloroform solution, then add trypsin to keep warm to obtain a mixed solution, and finally treat and purify with an ion exchanger to obtain refined transparent uric acid. The extraction rate of this method is extremely low, only about 1%, and the separation process is complicated, which makes hyaluronic acid expensive, reaching 5,000 US dollars/kg, which limits its large-scale use in cosmetics.
2、微生物发酵:以葡萄糖作为碳源发酵液,在培养基中发酵48小时,发酵结束后,过滤除去菌丝体和杂质,然后用醇沉淀法等简单操作即得到高纯度的产物。采用发酵法制造的透明质酸,优点是能按商品设计来设定分子量大小,发酵法的关键在于菌种的选择,多选用链球菌、乳酸球菌类等。2. Microbial fermentation: use glucose as the carbon source fermentation liquid, ferment in the culture medium for 48 hours, after the end of fermentation, filter to remove mycelia and impurities, and then use simple operations such as alcohol precipitation to obtain high-purity products. The hyaluronic acid produced by fermentation method has the advantage that the molecular weight can be set according to the product design. The key to the fermentation method is the selection of strains, such as streptococcus and lactococcus.
3、化学合成:采用天然酶聚合反应;首先使用多糖类聚合物合成“透明质酸氧氮杂环戊烯衍生物”,然后添加水分解酶,制造出衍生物和酶的复合体,最后在90℃反应液中清除其中的酶,就合成了透明质酸。采用人工合成法可大大降低透明质酸的制造成本,但结构较不精纯。3. Chemical synthesis: use natural enzyme polymerization; first use polysaccharide polymers to synthesize "hyaluronic acid oxazepine derivatives", then add water-splitting enzymes to create complexes of derivatives and enzymes, and finally Hyaluronic acid is synthesized by removing the enzymes in the reaction solution at 90°C. The artificial synthesis method can greatly reduce the manufacturing cost of hyaluronic acid, but the structure is less pure.
现有技术中,无论使用上述的哪种提炼方式,其中的透明质酸纯度都是较低的,因此均需要进行离心提纯,离心程度越高,纯度越高,但产率越低,传统的透明质酸离心提纯装置不能够根据纯度要求调试出合适的离心程度;另外,离心后的透明质酸需要过滤、导出的操作,过去的装置均需要分布完成,结构较为复杂,因此,现在急需一种透明质酸敷料离心提纯装置及使用方法来解决上述出现的问题。In the prior art, no matter which of the above extraction methods is used, the purity of hyaluronic acid is relatively low, so centrifugal purification is required. The higher the degree of centrifugation, the higher the purity, but the lower the yield. The traditional The hyaluronic acid centrifugal purification device cannot adjust the appropriate degree of centrifugation according to the purity requirements; in addition, the centrifuged hyaluronic acid needs to be filtered and exported, and the past devices have to be distributed and the structure is relatively complicated. Therefore, there is an urgent need for a A hyaluronic acid dressing centrifugal purification device and a method of use are provided to solve the above-mentioned problems.
发明内容Contents of the invention
针对现有技术存在的不足,本发明目的是提供一种透明质酸敷料离心提纯装置及使用方法,以解决上述背景技术中提出的问题,本发明结构合理,采用全新的分级离心筒,根据不同半径的离心筒调试出合适离心程度的透明质酸敷料,可快速分离出不同离心程度的透明质酸敷料,另外本发明的装置省去了复杂的导料组件,方便透明质酸敷料的导出,使用方便高效。Aiming at the deficiencies in the prior art, the object of the present invention is to provide a hyaluronic acid dressing centrifugal purification device and its use method to solve the problems raised in the above-mentioned background technology. The radius of the centrifugal cylinder adjusts the hyaluronic acid dressing with a suitable centrifugal degree, and can quickly separate the hyaluronic acid dressing with different centrifugal degrees. In addition, the device of the present invention eliminates the complicated material guide assembly, which is convenient for the export of the hyaluronic acid dressing. Easy and efficient to use.
为了实现上述目的,本发明是通过如下的技术方案来实现:一种透明质酸敷料离心提纯装置,包括离心机构、驱动机构、锁止机构、支撑机构和支撑托盘;In order to achieve the above object, the present invention is achieved through the following technical solutions: a hyaluronic acid dressing centrifugal purification device, including a centrifugal mechanism, a driving mechanism, a locking mechanism, a supporting mechanism and a supporting tray;
所述锁止机构用于驱动离心机构转动,所述锁止机构包括电机和导向轴,所述电机设置在支撑托盘上,所述电机的动力轴上设置有磁性限位盘,所述导向轴连接在电机的动力轴上;The locking mechanism is used to drive the centrifugal mechanism to rotate. The locking mechanism includes a motor and a guide shaft. The motor is arranged on the support tray. Connected to the power shaft of the motor;
所述离心机构用于对不同离心程度的透明质酸敷料离心提纯,所述离心机构包括离心筒和离心滤膜,所述离心筒套设在导向轴上,所述离心滤膜设置在离心筒内,所述离心筒上贯通设置有液位计;The centrifugal mechanism is used for centrifugal purification of hyaluronic acid dressings with different centrifugal degrees. The centrifugal mechanism includes a centrifugal cylinder and a centrifugal filter membrane, the centrifugal cylinder is set on the guide shaft, and the centrifugal filter membrane is arranged on the centrifugal cylinder. Inside, the centrifuge cylinder is provided with a liquid level gauge through it;
所述支撑机构用于对离心筒上下支撑移动,所述支撑机构为一个电动伸缩杆。The support mechanism is used to support and move the centrifugal cylinder up and down, and the support mechanism is an electric telescopic rod.
进一步地,所述离心筒设有若干个,每个离心筒的直径不同,若干个离心筒采用同心圆式叠加套设。Further, there are several centrifugal cylinders, each of which has a different diameter, and several centrifugal cylinders are superimposed and sleeved in concentric circles.
进一步地,所述离心筒的顶部开设有注药口,且注药口贯穿设置有注药塞子,所述离心筒的底部开设有出药口,且出药口贯穿设置有电磁阀或出药塞子,所述离心筒的内部设置有配重块,配重块用于平衡离心筒旋转时的离心力。Further, a drug injection port is opened on the top of the centrifugal cylinder, and a drug injection plug is provided through the drug injection port, and a drug outlet is opened at the bottom of the centrifugal cylinder, and a solenoid valve or a drug outlet is provided through the drug outlet. The plug is provided with a counterweight inside the centrifugal cylinder, and the counterweight is used to balance the centrifugal force when the centrifugal cylinder rotates.
进一步地,所述离心滤膜为两个端面镂空的圆台结构,所述离心滤膜固定设置在离心筒内。Further, the centrifugal filter membrane has a circular truncated structure with two hollow ends, and the centrifugal filter membrane is fixedly arranged in the centrifugal cylinder.
进一步地,所述磁性限位盘与离心筒底部磁性吸引。Further, the magnetic limit plate is magnetically attracted to the bottom of the centrifuge cylinder.
进一步地,所述支撑托盘上设置有若干个用于接收不同离心筒内液体的接料槽,所述支撑托盘上设置有用于离心筒定位停止的锁止机构,所述锁止包括电磁铁和铁片,所述电磁铁设置在支撑托盘上,所述铁片贴附在离心筒下表面,所述铁片的旋转面与电磁铁的中心线重合。Further, the support tray is provided with several receiving troughs for receiving liquids in different centrifuge cylinders, and the support tray is provided with a locking mechanism for positioning and stopping the centrifuge cylinders. The locking includes electromagnets and An iron sheet, the electromagnet is arranged on the support tray, the iron sheet is attached to the lower surface of the centrifugal cylinder, and the rotating surface of the iron sheet coincides with the centerline of the electromagnet.
进一步地,所述电动伸缩杆至少设置三个,每个电动伸缩杆等间距地分布在支撑托盘上表面。Further, there are at least three electric telescopic rods, and each electric telescopic rod is equally spaced on the upper surface of the support tray.
进一步地,所述导向轴表面设置有齿牙,最内侧的离心筒内侧开设有齿套,齿套与齿牙相匹配。Further, teeth are provided on the surface of the guide shaft, and a tooth sleeve is provided inside the innermost centrifugal cylinder, and the tooth sleeve is matched with the teeth.
进一步地,本发明的的一种透明质酸敷料离心提纯装置的使用方法,包括如下步骤:Further, a method for using a hyaluronic acid dressing centrifugal purification device of the present invention includes the following steps:
步骤(1)、支撑托盘放置在指定支撑平面上,将多个不同直径的离心筒按照同心圆样式叠加套设,并最终套设成一个整体结构;Step (1), the support tray is placed on the designated support plane, and multiple centrifuges with different diameters are superimposed and nested according to the concentric circle pattern, and finally nested into an overall structure;
步骤(1-1)、将步骤(1)中的整体结构插入导向轴上,离心筒底部与磁性限位盘磁性贴合;Step (1-1), insert the overall structure in step (1) onto the guide shaft, and magnetically attach the bottom of the centrifugal cylinder to the magnetic limit plate;
步骤(2)、打开离心筒上的注药口,向离心筒内倒入待离心处理的透明质酸敷料,通过不断观察液位计的读数,将指定体积的透明质酸敷料注入离心筒内,液位计到达指定体积读数后,盖紧注药口;Step (2), open the injection port on the centrifuge cylinder, pour the hyaluronic acid dressing to be centrifuged into the centrifuge cylinder, and inject the specified volume of hyaluronic acid dressing into the centrifuge cylinder by constantly observing the readings of the liquid level gauge , after the liquid level gauge reaches the specified volume reading, close the injection port tightly;
步骤(3)、将电机通电,电机通过导向轴带动离心筒高速离心转动一段时间,离心筒高速转动后,离心筒内的透明质酸敷料经过离心力作用分层,并经过离心滤膜过滤出离心后的透明质酸敷料物质,过滤后的透明质酸敷料进入离心筒底部,电机通电一段时间后,将电机断电;Step (3), power on the motor, and the motor drives the centrifuge cylinder to rotate at high speed for a period of time through the guide shaft. After the centrifuge cylinder rotates at high speed, the hyaluronic acid dressing in the centrifuge cylinder is layered by centrifugal force and filtered out by the centrifugal filter membrane. The final hyaluronic acid dressing material, the filtered hyaluronic acid dressing enters the bottom of the centrifugal cylinder, and after the motor is powered on for a period of time, the motor is powered off;
步骤(4)、电机断电的同时,将电磁铁通电,电磁铁通电后不断吸附旋转的铁片,最终使铁片吸附在电磁铁最上方,离心筒停止,且此时,离心筒的出药口正好对准接料槽;Step (4), while the motor is powered off, power on the electromagnet. After the electromagnet is powered on, the rotating iron piece is continuously adsorbed, and finally the iron piece is adsorbed on the top of the electromagnet, and the centrifugal cylinder stops. At this time, the centrifugal cylinder exits The drug mouth is just aligned with the receiving trough;
步骤(5)、待离心机最终停下的一刻,电动伸缩杆通电,电动伸缩杆支撑离心筒向上移动一段距离;Step (5), when the centrifuge finally stops, the electric telescopic rod is energized, and the electric telescopic rod supports the centrifugal cylinder to move upward for a certain distance;
步骤(5-1)、此时打开出药口处的电磁阀过或者出药堵头,将离心筒内离心后的透明质酸敷料倒入相应的接料槽内;Step (5-1), at this time, open the solenoid valve at the drug outlet or the drug outlet plug, and pour the hyaluronic acid dressing centrifuged in the centrifuge cylinder into the corresponding receiving tank;
步骤(6)、最后取出接料槽,电动伸缩杆通电下降至最低位,使离心筒底部重新与磁性限位盘磁性吸附,完成一个离心循环,可按照步骤(1)-步骤(6)离心加工另一批透明质酸敷料;Step (6), finally take out the receiving trough, power on the electric telescopic rod and lower it to the lowest position, so that the bottom of the centrifuge cylinder is magnetically adsorbed to the magnetic limit plate again, and a centrifugal cycle is completed, which can be centrifuged according to steps (1)-step (6) Processing another batch of hyaluronic acid dressing;
步骤(6-1)、离心结束后,可继续将电动伸缩杆通电,电动伸缩杆支撑离心筒离开磁性限位盘;然后将离心筒从导向轴上取出,并打开离心筒上下两侧的注药口和出药口,清洗离心筒内部所述磁性限位盘与离心筒底部磁性吸引。Step (6-1), after the centrifugation is completed, continue to power on the electric telescopic rod, and the electric telescopic rod supports the centrifuge cylinder away from the magnetic limit plate; then take the centrifuge cylinder out of the guide shaft, and open the injection valves on the upper and lower sides of the centrifuge cylinder. Drug port and drug outlet, clean the magnetic limit plate inside the centrifuge cylinder and magnetically attract the bottom of the centrifuge cylinder.
进一步地,步骤(2)中,将离心程度高,需要大离心力的透明质酸敷料放入大直径的离心筒内,将离心程度低,需要小离心力的透明质酸敷料放入小直径的离心筒内;步骤(3)中,电机通电时间根据透明质酸敷料离心时间进行设定。Furthermore, in step (2), put the hyaluronic acid dressing with a high degree of centrifugation and requires a large centrifugal force into a large-diameter centrifuge cylinder, and put the hyaluronic acid dressing with a low degree of centrifugation and requires a small centrifugal force into a centrifuge with a small diameter. In the barrel; in step (3), the power-on time of the motor is set according to the centrifugation time of the hyaluronic acid dressing.
本发明的有益效果:Beneficial effects of the present invention:
1、本发明的离心机构用于对不同离心程度的透明质酸敷料离心提纯,离心机构包括离心筒和离心滤膜,离心筒套设在导向轴上,离心滤膜设置在离心筒内,离心滤膜的加入使得离心后的透明质酸敷料再一次进行过滤分层,以起到提纯过滤其中杂质的效果;1. The centrifugal mechanism of the present invention is used for centrifugal purification of hyaluronic acid dressings with different centrifugal degrees. The centrifugal mechanism includes a centrifugal cylinder and a centrifugal filter membrane. The centrifugal cylinder is sleeved on the guide shaft, and the centrifugal filter membrane is arranged in the centrifugal cylinder. The addition of the filter membrane allows the hyaluronic acid dressing to be filtered and layered again after centrifugation, so as to purify and filter the impurities;
2、本发明的离心筒设有若干个,每个离心筒的直径不同,若干个离心筒采用同心圆式叠加套设;此设计使得在同一转速下,根据离心力公式F=mω2r其中ω表示非惯性系自身转动的角速度,r表示旋转半径,m表示物体的质量,可以看出,相同质量m和角速度ω情况下,离心力F与旋转半径r呈正线性相关,因此,不同半径的离心筒可以得到不同的离心力;2. There are several centrifugal cylinders of the present invention, each of which has a different diameter, and several centrifugal cylinders are superimposed and sleeved in concentric circles; this design makes it possible to use the centrifugal force formula F=mω 2 r where ω Represents the angular velocity of the non-inertial system's own rotation, r represents the radius of rotation, and m represents the mass of the object. It can be seen that under the same mass m and angular velocity ω, the centrifugal force F has a positive linear correlation with the radius of rotation r. Therefore, centrifugal cylinders with different radii Different centrifugal forces can be obtained;
3、本发明的锁止机构用于驱动离心机构转动;通过电机带动离心筒进行高速离心转动,导向轴的设计便于离心筒的拆卸;3. The locking mechanism of the present invention is used to drive the centrifugal mechanism to rotate; the centrifugal cylinder is driven by the motor to perform high-speed centrifugal rotation, and the design of the guide shaft facilitates the disassembly of the centrifugal cylinder;
4、本发明的支撑机构用于对离心筒上下支撑移动,支撑机构为一个电动伸缩杆,电动伸缩杆至少设置三个,每个电动伸缩杆等间距地分布在支撑托盘上表面,通过电动伸缩杆上下移动,支撑离心筒上下移动,方便离心筒内的透明质酸敷料的导出;4. The support mechanism of the present invention is used to support and move the centrifuge cylinder up and down. The support mechanism is an electric telescopic rod, and at least three electric telescopic rods are provided. The rod moves up and down, supports the centrifuge cylinder to move up and down, and facilitates the export of the hyaluronic acid dressing in the centrifuge cylinder;
5、本发明结构合理,采用全新的分级离心筒,根据不同半径的离心筒调试出合适离心程度的透明质酸敷料,可快速分离出不同离心程度的透明质酸敷料,另外本发明的装置省去了复杂的导料组件,方便透明质酸敷料的导出,使用方便高效。5. The present invention has a reasonable structure, adopts a brand-new grading centrifuge cylinder, adjusts hyaluronic acid dressings with a suitable centrifugal degree according to centrifugal cylinders with different radii, and can quickly separate hyaluronic acid dressings with different centrifugation degrees. In addition, the device of the present invention saves The complex material guide components are removed, which facilitates the export of hyaluronic acid dressings, and is convenient and efficient to use.
附图说明Description of drawings
通过阅读参照以下附图对非限制性实施例所作的详细描述,本发明的其它特征、目的和优点将会变得更明显:Other characteristics, objects and advantages of the present invention will become more apparent by reading the detailed description of non-limiting embodiments made with reference to the following drawings:
图1为本发明一种透明质酸敷料离心提纯装置的结构示意图;Fig. 1 is the structural representation of a kind of hyaluronic acid dressing centrifugal purification device of the present invention;
图2为本发明一种透明质酸敷料离心提纯装置的正视剖面图;Fig. 2 is the front section view of a hyaluronic acid dressing centrifugal purification device of the present invention;
图3为本发明一种透明质酸敷料离心提纯装置的左视剖面图;Fig. 3 is a left view sectional view of a hyaluronic acid dressing centrifugal purification device of the present invention;
图4为本发明一种透明质酸敷料离心提纯装置中离心滤膜的结构示意图;Fig. 4 is a structural schematic diagram of a centrifugal filter membrane in a hyaluronic acid dressing centrifugal purification device of the present invention;
图5为本发明一种透明质酸敷料离心提纯装置中导向轴的结构示意图;Fig. 5 is a structural schematic diagram of a guide shaft in a hyaluronic acid dressing centrifugal purification device of the present invention;
图中:1离心机构、11离心筒、12注药口、13液位计、14离心滤膜、15出药口、16配重块、21支撑托盘、22接料槽、3驱动机构、31电机、32磁性限位盘、33导向轴、4锁止机构、41电磁铁、42铁片、5支撑机构。In the figure: 1 centrifugal mechanism, 11 centrifugal cylinder, 12 drug injection port, 13 liquid level gauge, 14 centrifugal filter membrane, 15 drug outlet, 16 counterweight, 21 support tray, 22 receiving trough, 3 drive mechanism, 31 Motor, 32 magnetic limit discs, 33 guide shafts, 4 locking mechanisms, 41 electromagnets, 42 iron sheets, 5 supporting mechanisms.
具体实施方式Detailed ways
为使本发明实现的技术手段、创作特征、达成目的与功效易于明白了解,下面结合具体实施方式,进一步阐述本发明。In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments.
请参阅图1-图5,本发明提供一种技术方案:一种透明质酸敷料离心提纯装置,包括离心机构1、驱动机构3、锁止机构4、支撑机构5和支撑托盘21;解决了过去的透明质酸敷料不能够根据离心程度的需要进行分级提纯,离心后的透明质酸敷料导出过程复杂的问题。Please refer to Figures 1-5, the present invention provides a technical solution: a hyaluronic acid dressing centrifugal purification device, including a
本发明的锁止机构4用于驱动离心机构1转动,锁止机构4包括电机31和导向轴33,电机31设置在支撑托盘21上,电机31的动力轴上设置有磁性限位盘32,导向轴33连接在电机31的动力轴上,导向轴33表面设置有齿牙,最内侧的离心筒11内侧开设有齿套,齿套与齿牙相匹配;通过电机31带动离心筒11进行高速离心转动,导向轴33的设计便于离心筒11的拆卸。The
本发明的离心机构1用于对不同离心程度的透明质酸敷料离心提纯,离心机构1包括离心筒11和离心滤膜14,离心筒11套设在导向轴33上,离心滤膜14设置在离心筒11内,离心滤膜14的加入使得离心后的透明质酸敷料再一次进行过滤分层,以起到提纯过滤其中杂质的效果;The
离心筒11设有若干个,每个离心筒11的直径不同,若干个离心筒11采用同心圆式叠加套设;此设计使得在同一转速下,根据离心力公式F=mω2r其中ω表示非惯性系自身转动的角速度,r表示旋转半径,m表示物体的质量,可以看出,相同质量m和角速度ω情况下,离心力F与旋转半径r呈正线性相关,因此,不同半径的离心筒11可以得到不同的离心力。There are several
本发明的支撑机构5用于对离心筒11上下支撑移动,支撑机构5为一个电动伸缩杆,电动伸缩杆至少设置三个,每个电动伸缩杆等间距地分布在支撑托盘21上表面,通过电动伸缩杆上下移动,支撑离心筒11上下移动,方便离心筒11内的透明质酸敷料的导出。The
本发明的离心筒11的顶部开设有注药口12,且注药口12贯穿设置有注药塞子,离心筒11的底部开设有出药口15,且出药口15贯穿设置有电磁阀或出药塞子,离心筒11的内部设置有配重块16,配重块16用于平衡离心筒11旋转时的离心力,防止离心筒11高速转动过程中手里不平衡,发生偏心旋转,影响离心筒11的正常旋转。The top of the
本发明的离心滤膜14为两个端面镂空的圆台结构,离心滤膜固定设置在离心筒11内,此设计为使高速旋转下的透明质酸敷料受离心力而穿过离心滤膜14进行过滤,进一步提高透明质酸敷料的纯度。The
本发明的磁性限位盘32与离心筒11底部磁性吸引,防止离心筒11高速旋转时向上移动跳起。The
本发明的支撑托盘21上设置有若干个用于接收不同离心筒11内液体的接料槽22;The
支撑托盘21上设置有用于离心筒11定位停止的锁止机构4,锁止包括电磁铁41和铁片42,电磁铁41设置在支撑托盘21上,铁片42贴附在离心筒11下表面,铁片42的旋转面与电磁铁41的中心线重合,此设计使得离心筒11停止时,离心筒11的出药口15能够对准接料槽22导出透明质酸敷料。The
具体工作原理:首先将支撑托盘21放置在指定支撑平面上,将多个不同直径的离心筒11按照同心圆样式叠加套设,并最终套设成一个整体结构;并将该整体结构插入导向轴33上,离心筒11底部与磁性限位盘32磁性贴合;Specific working principle: First, place the
然后打开离心筒11上的注药口12,向离心筒11内倒入待离心处理的透明质酸敷料,通过不断观察液位计13的读数,将指定体积的透明质酸敷料注入离心筒11内,液位计13到达指定体积读数后,盖紧注药口12;将离心程度高,需要大离心力的透明质酸敷料放入大直径的离心筒11内,将离心程度低,需要小离心力的透明质酸敷料放入小直径的离心筒11内;Then open the
然后将电机31通电,电机31通过导向轴33带动离心筒11高速离心转动一段时间,离心筒11高速转动后,离心筒11内的透明质酸敷料经过离心力作用分层;根据离心力公式F=mω2r其中ω表示非惯性系自身转动的角速度,r表示旋转半径,m表示物体的质量,可以看出,相同质量m和角速度ω情况下,离心力F与旋转半径r呈正线性相关,因此,不同半径的离心筒11可以得到不同的离心力;Then the
然后经过高速旋转下的透明质酸敷料受离心力而穿过离心滤膜14进行过滤,进一步提高透明质酸敷料的纯度,过滤后的透明质酸敷料进入离心筒11底部,电机31通电一段时间后,电机31通电时间根据透明质酸敷料离心时间进行设定,随后将电机31断电;Then the hyaluronic acid dressing under high-speed rotation is subjected to centrifugal force to pass through the
随后电机31断电的同时,将电磁铁41通电,电磁铁41通电后不断吸附旋转的铁片42,最终使铁片42吸附在电磁铁41最上方,离心筒11停止,且此时,离心筒11的出药口15正好对准接料槽22;Then when the
待离心机最终停下的一刻,电动伸缩杆通电,电动伸缩杆支撑离心筒11向上移动一段距离;此时打开出药口15处的电磁阀过或者出药堵头,将离心筒11内离心后的透明质酸敷料倒入相应的接料槽22内;最后取出接料槽22,电动伸缩杆通电下降至最低位,使离心筒11底部重新与磁性限位盘32磁性吸附,完成一个离心循环,可按照上述步骤离心加工另一批透明质酸敷料;The moment the centrifuge finally stops, the electric telescopic rod is energized, and the electric telescopic rod supports the
最后离心结束后,可继续将电动伸缩杆通电,电动伸缩杆支撑离心筒11离开磁性限位盘32;然后将离心筒11从导向轴33上取出,并打开离心筒11上下两侧的注药口12。。Finally, after the centrifugation is completed, the electric telescopic rod can continue to be energized, and the electric telescopic rod supports the
以上显示和描述了本发明的基本原理和主要特征和本发明的优点,对于本领域技术人员而言,显然本发明不限于上述示范性实施例的细节,而且在不背离本发明的精神或基本特征的情况下,能够以其他的具体形式实现本发明。因此,无论从哪一点来看,均应将实施例看作是示范性的,而且是非限制性的,本发明的范围由所附权利要求而不是上述说明限定,因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。不应将权利要求中的任何附图标记视为限制所涉及的权利要求。The basic principles and main features of the present invention and the advantages of the present invention have been shown and described above. For those skilled in the art, it is obvious that the present invention is not limited to the details of the above-mentioned exemplary embodiments, and without departing from the spirit or fundamentals of the present invention. The present invention can be implemented in other specific forms without any specific features. Accordingly, the embodiments should be regarded in all points of view as exemplary and not restrictive, the scope of the invention being defined by the appended claims rather than the foregoing description, and it is therefore intended that the scope of the invention be defined by the appended claims rather than by the foregoing description. All changes within the meaning and range of equivalents of the elements are embraced in the present invention. Any reference sign in a claim should not be construed as limiting the claim concerned.
此外,应当理解,虽然本说明书按照实施方式加以描述,但并非每个实施方式仅包含一个独立的技术方案,说明书的这种叙述方式仅仅是为清楚起见,本领域技术人员应当将说明书作为一个整体,各实施例中的技术方案也可以经适当组合,形成本领域技术人员可以理解的其他实施方式。In addition, it should be understood that although this specification is described according to implementation modes, not each implementation mode only includes an independent technical solution, and this description in the specification is only for clarity, and those skilled in the art should take the specification as a whole , the technical solutions in the various embodiments can also be properly combined to form other implementations that can be understood by those skilled in the art.
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