[go: up one dir, main page]

CN113996448B - A kind of hyaluronic acid dressing centrifugal purification device and using method - Google Patents

A kind of hyaluronic acid dressing centrifugal purification device and using method Download PDF

Info

Publication number
CN113996448B
CN113996448B CN202111242815.7A CN202111242815A CN113996448B CN 113996448 B CN113996448 B CN 113996448B CN 202111242815 A CN202111242815 A CN 202111242815A CN 113996448 B CN113996448 B CN 113996448B
Authority
CN
China
Prior art keywords
centrifugal
cylinder
hyaluronic acid
centrifuge
acid dressing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202111242815.7A
Other languages
Chinese (zh)
Other versions
CN113996448A (en
Inventor
徐林
金玉
徐念沁
鲁锦标
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanjing Tzong Blotechnology Co ltd
Original Assignee
Nanjing Tzong Blotechnology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanjing Tzong Blotechnology Co ltd filed Critical Nanjing Tzong Blotechnology Co ltd
Priority to CN202111242815.7A priority Critical patent/CN113996448B/en
Publication of CN113996448A publication Critical patent/CN113996448A/en
Application granted granted Critical
Publication of CN113996448B publication Critical patent/CN113996448B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B5/00Other centrifuges
    • B04B5/02Centrifuges consisting of a plurality of separate bowls rotating round an axis situated between the bowls
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D63/00Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/16Rotary, reciprocated or vibrated modules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B11/00Feeding, charging, or discharging bowls
    • B04B11/04Periodical feeding or discharging; Control arrangements therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B5/00Other centrifuges
    • B04B5/04Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B7/00Elements of centrifuges
    • B04B7/08Rotary bowls
    • B04B7/12Inserts, e.g. armouring plates
    • B04B7/16Sieves or filters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B9/00Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
    • B04B9/02Electric motor drives
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04BCENTRIFUGES
    • B04B9/00Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
    • B04B9/08Arrangement or disposition of transmission gearing ; Couplings; Brakes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/10Process efficiency

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Centrifugal Separators (AREA)

Abstract

本发明提供一种透明质酸敷料离心提纯装置及使用方法,该装置包括离心机构、驱动机构、锁止机构、支撑机构和支撑托盘;锁止机构用于驱动离心机构转动;离心机构用于对不同离心程度的透明质酸敷料离心提纯;支撑机构用于对离心筒上下支撑移动,解决了过去的透明质酸敷料不能够根据离心程度的需要进行分级提纯,离心后的透明质酸敷料导出过程复杂的问题,本发明结构合理,采用全新的分级离心筒,根据不同半径的离心筒调试出合适离心程度的透明质酸敷料,可快速分离出不同离心程度的透明质酸敷料,另外本发明的装置省去了复杂的导料组件,方便透明质酸敷料的导出,使用方便高效。

Figure 202111242815

The present invention provides a hyaluronic acid dressing centrifugal purification device and its use method. The device includes a centrifugal mechanism, a driving mechanism, a locking mechanism, a supporting mechanism and a supporting tray; the locking mechanism is used to drive the centrifugal mechanism to rotate; the centrifugal mechanism is used to Centrifugal purification of hyaluronic acid dressings with different degrees of centrifugation; the support mechanism is used to support and move the centrifuge cylinder up and down, which solves the problem that hyaluronic acid dressings in the past cannot be graded and purified according to the degree of centrifugation, and the export process of hyaluronic acid dressings after centrifugation Complicated problems, the present invention has a reasonable structure, adopts a brand-new grading centrifuge cylinder, adjusts hyaluronic acid dressings with appropriate centrifugal degrees according to centrifugal cylinders with different radii, and can quickly separate hyaluronic acid dressings with different centrifugal degrees. In addition, the present invention The device eliminates complicated material guide components, facilitates the export of the hyaluronic acid dressing, and is convenient and efficient to use.

Figure 202111242815

Description

一种透明质酸敷料离心提纯装置及使用方法A kind of hyaluronic acid dressing centrifugal purification device and using method

技术领域technical field

本发明是一种透明质酸敷料离心提纯装置及使用方法,涉及透明质酸敷料离心提纯领域。The invention relates to a hyaluronic acid dressing centrifugal purification device and a use method thereof, and relates to the field of hyaluronic acid dressing centrifugal purification.

背景技术Background technique

透明质酸,又称玻尿酸,是D-葡萄糖醛酸及N-乙酰葡糖胺组成的双糖单位糖胺聚糖。透明质酸是一种酸性粘多糖,1934年美国哥伦比亚大学眼科教授Meyer等首先从牛眼玻璃体中分离出该物质。透明质酸具有较高临床价值的生化药物,广泛应用于各类眼科手术,如晶体植入、角膜移植和抗青光眼手术等。还可用于治疗关节炎和加速伤口愈合。将其用于化妆品中,能起到独特的保护皮肤作用,可保持皮肤滋润光滑、细腻柔嫩、富有弹性,具有防皱、抗皱、美容保健和恢复皮肤生理功能的作用。Hyaluronic acid, also known as hyaluronic acid, is a disaccharide unit glycosaminoglycan composed of D-glucuronic acid and N-acetylglucosamine. Hyaluronic acid is an acidic mucopolysaccharide. In 1934, Meyer, a professor of ophthalmology at Columbia University in the United States, first isolated the substance from the bovine vitreous. Hyaluronic acid is a biochemical drug with high clinical value, and is widely used in various ophthalmic operations, such as lens implantation, corneal transplantation and anti-glaucoma surgery. It is also used to treat arthritis and accelerate wound healing. Used in cosmetics, it can play a unique role in protecting the skin. It can keep the skin moist, smooth, delicate, soft and elastic. It has the functions of anti-wrinkle, anti-wrinkle, beauty care and restoration of skin physiological functions.

透明质酸的提炼的方法有三种:There are three methods of refining hyaluronic acid:

1、动物组织:主要原料是鸡冠和牛眼玻璃体等。用丙酮或乙醇将原料脱脂、脱水,用蒸馏水浸泡、过滤,然后以氯化钠水溶液和氯仿溶液处理,之后加入胰蛋白酶保温后得到混合液,最后用离子交换剂进行处理、纯化得到精制的透明质酸。这种方法提取率极低,仅1%左右,分离过程复杂,致使透明质酸价格昂贵,达5000美元/公斤,限制了在化妆品中大的量使用。1. Animal tissue: the main raw materials are cockscomb and vitreous body of bull's eye. Degrease and dehydrate the raw material with acetone or ethanol, soak in distilled water, filter, then treat with sodium chloride aqueous solution and chloroform solution, then add trypsin to keep warm to obtain a mixed solution, and finally treat and purify with an ion exchanger to obtain refined transparent uric acid. The extraction rate of this method is extremely low, only about 1%, and the separation process is complicated, which makes hyaluronic acid expensive, reaching 5,000 US dollars/kg, which limits its large-scale use in cosmetics.

2、微生物发酵:以葡萄糖作为碳源发酵液,在培养基中发酵48小时,发酵结束后,过滤除去菌丝体和杂质,然后用醇沉淀法等简单操作即得到高纯度的产物。采用发酵法制造的透明质酸,优点是能按商品设计来设定分子量大小,发酵法的关键在于菌种的选择,多选用链球菌、乳酸球菌类等。2. Microbial fermentation: use glucose as the carbon source fermentation liquid, ferment in the culture medium for 48 hours, after the end of fermentation, filter to remove mycelia and impurities, and then use simple operations such as alcohol precipitation to obtain high-purity products. The hyaluronic acid produced by fermentation method has the advantage that the molecular weight can be set according to the product design. The key to the fermentation method is the selection of strains, such as streptococcus and lactococcus.

3、化学合成:采用天然酶聚合反应;首先使用多糖类聚合物合成“透明质酸氧氮杂环戊烯衍生物”,然后添加水分解酶,制造出衍生物和酶的复合体,最后在90℃反应液中清除其中的酶,就合成了透明质酸。采用人工合成法可大大降低透明质酸的制造成本,但结构较不精纯。3. Chemical synthesis: use natural enzyme polymerization; first use polysaccharide polymers to synthesize "hyaluronic acid oxazepine derivatives", then add water-splitting enzymes to create complexes of derivatives and enzymes, and finally Hyaluronic acid is synthesized by removing the enzymes in the reaction solution at 90°C. The artificial synthesis method can greatly reduce the manufacturing cost of hyaluronic acid, but the structure is less pure.

现有技术中,无论使用上述的哪种提炼方式,其中的透明质酸纯度都是较低的,因此均需要进行离心提纯,离心程度越高,纯度越高,但产率越低,传统的透明质酸离心提纯装置不能够根据纯度要求调试出合适的离心程度;另外,离心后的透明质酸需要过滤、导出的操作,过去的装置均需要分布完成,结构较为复杂,因此,现在急需一种透明质酸敷料离心提纯装置及使用方法来解决上述出现的问题。In the prior art, no matter which of the above extraction methods is used, the purity of hyaluronic acid is relatively low, so centrifugal purification is required. The higher the degree of centrifugation, the higher the purity, but the lower the yield. The traditional The hyaluronic acid centrifugal purification device cannot adjust the appropriate degree of centrifugation according to the purity requirements; in addition, the centrifuged hyaluronic acid needs to be filtered and exported, and the past devices have to be distributed and the structure is relatively complicated. Therefore, there is an urgent need for a A hyaluronic acid dressing centrifugal purification device and a method of use are provided to solve the above-mentioned problems.

发明内容Contents of the invention

针对现有技术存在的不足,本发明目的是提供一种透明质酸敷料离心提纯装置及使用方法,以解决上述背景技术中提出的问题,本发明结构合理,采用全新的分级离心筒,根据不同半径的离心筒调试出合适离心程度的透明质酸敷料,可快速分离出不同离心程度的透明质酸敷料,另外本发明的装置省去了复杂的导料组件,方便透明质酸敷料的导出,使用方便高效。Aiming at the deficiencies in the prior art, the object of the present invention is to provide a hyaluronic acid dressing centrifugal purification device and its use method to solve the problems raised in the above-mentioned background technology. The radius of the centrifugal cylinder adjusts the hyaluronic acid dressing with a suitable centrifugal degree, and can quickly separate the hyaluronic acid dressing with different centrifugal degrees. In addition, the device of the present invention eliminates the complicated material guide assembly, which is convenient for the export of the hyaluronic acid dressing. Easy and efficient to use.

为了实现上述目的,本发明是通过如下的技术方案来实现:一种透明质酸敷料离心提纯装置,包括离心机构、驱动机构、锁止机构、支撑机构和支撑托盘;In order to achieve the above object, the present invention is achieved through the following technical solutions: a hyaluronic acid dressing centrifugal purification device, including a centrifugal mechanism, a driving mechanism, a locking mechanism, a supporting mechanism and a supporting tray;

所述锁止机构用于驱动离心机构转动,所述锁止机构包括电机和导向轴,所述电机设置在支撑托盘上,所述电机的动力轴上设置有磁性限位盘,所述导向轴连接在电机的动力轴上;The locking mechanism is used to drive the centrifugal mechanism to rotate. The locking mechanism includes a motor and a guide shaft. The motor is arranged on the support tray. Connected to the power shaft of the motor;

所述离心机构用于对不同离心程度的透明质酸敷料离心提纯,所述离心机构包括离心筒和离心滤膜,所述离心筒套设在导向轴上,所述离心滤膜设置在离心筒内,所述离心筒上贯通设置有液位计;The centrifugal mechanism is used for centrifugal purification of hyaluronic acid dressings with different centrifugal degrees. The centrifugal mechanism includes a centrifugal cylinder and a centrifugal filter membrane, the centrifugal cylinder is set on the guide shaft, and the centrifugal filter membrane is arranged on the centrifugal cylinder. Inside, the centrifuge cylinder is provided with a liquid level gauge through it;

所述支撑机构用于对离心筒上下支撑移动,所述支撑机构为一个电动伸缩杆。The support mechanism is used to support and move the centrifugal cylinder up and down, and the support mechanism is an electric telescopic rod.

进一步地,所述离心筒设有若干个,每个离心筒的直径不同,若干个离心筒采用同心圆式叠加套设。Further, there are several centrifugal cylinders, each of which has a different diameter, and several centrifugal cylinders are superimposed and sleeved in concentric circles.

进一步地,所述离心筒的顶部开设有注药口,且注药口贯穿设置有注药塞子,所述离心筒的底部开设有出药口,且出药口贯穿设置有电磁阀或出药塞子,所述离心筒的内部设置有配重块,配重块用于平衡离心筒旋转时的离心力。Further, a drug injection port is opened on the top of the centrifugal cylinder, and a drug injection plug is provided through the drug injection port, and a drug outlet is opened at the bottom of the centrifugal cylinder, and a solenoid valve or a drug outlet is provided through the drug outlet. The plug is provided with a counterweight inside the centrifugal cylinder, and the counterweight is used to balance the centrifugal force when the centrifugal cylinder rotates.

进一步地,所述离心滤膜为两个端面镂空的圆台结构,所述离心滤膜固定设置在离心筒内。Further, the centrifugal filter membrane has a circular truncated structure with two hollow ends, and the centrifugal filter membrane is fixedly arranged in the centrifugal cylinder.

进一步地,所述磁性限位盘与离心筒底部磁性吸引。Further, the magnetic limit plate is magnetically attracted to the bottom of the centrifuge cylinder.

进一步地,所述支撑托盘上设置有若干个用于接收不同离心筒内液体的接料槽,所述支撑托盘上设置有用于离心筒定位停止的锁止机构,所述锁止包括电磁铁和铁片,所述电磁铁设置在支撑托盘上,所述铁片贴附在离心筒下表面,所述铁片的旋转面与电磁铁的中心线重合。Further, the support tray is provided with several receiving troughs for receiving liquids in different centrifuge cylinders, and the support tray is provided with a locking mechanism for positioning and stopping the centrifuge cylinders. The locking includes electromagnets and An iron sheet, the electromagnet is arranged on the support tray, the iron sheet is attached to the lower surface of the centrifugal cylinder, and the rotating surface of the iron sheet coincides with the centerline of the electromagnet.

进一步地,所述电动伸缩杆至少设置三个,每个电动伸缩杆等间距地分布在支撑托盘上表面。Further, there are at least three electric telescopic rods, and each electric telescopic rod is equally spaced on the upper surface of the support tray.

进一步地,所述导向轴表面设置有齿牙,最内侧的离心筒内侧开设有齿套,齿套与齿牙相匹配。Further, teeth are provided on the surface of the guide shaft, and a tooth sleeve is provided inside the innermost centrifugal cylinder, and the tooth sleeve is matched with the teeth.

进一步地,本发明的的一种透明质酸敷料离心提纯装置的使用方法,包括如下步骤:Further, a method for using a hyaluronic acid dressing centrifugal purification device of the present invention includes the following steps:

步骤(1)、支撑托盘放置在指定支撑平面上,将多个不同直径的离心筒按照同心圆样式叠加套设,并最终套设成一个整体结构;Step (1), the support tray is placed on the designated support plane, and multiple centrifuges with different diameters are superimposed and nested according to the concentric circle pattern, and finally nested into an overall structure;

步骤(1-1)、将步骤(1)中的整体结构插入导向轴上,离心筒底部与磁性限位盘磁性贴合;Step (1-1), insert the overall structure in step (1) onto the guide shaft, and magnetically attach the bottom of the centrifugal cylinder to the magnetic limit plate;

步骤(2)、打开离心筒上的注药口,向离心筒内倒入待离心处理的透明质酸敷料,通过不断观察液位计的读数,将指定体积的透明质酸敷料注入离心筒内,液位计到达指定体积读数后,盖紧注药口;Step (2), open the injection port on the centrifuge cylinder, pour the hyaluronic acid dressing to be centrifuged into the centrifuge cylinder, and inject the specified volume of hyaluronic acid dressing into the centrifuge cylinder by constantly observing the readings of the liquid level gauge , after the liquid level gauge reaches the specified volume reading, close the injection port tightly;

步骤(3)、将电机通电,电机通过导向轴带动离心筒高速离心转动一段时间,离心筒高速转动后,离心筒内的透明质酸敷料经过离心力作用分层,并经过离心滤膜过滤出离心后的透明质酸敷料物质,过滤后的透明质酸敷料进入离心筒底部,电机通电一段时间后,将电机断电;Step (3), power on the motor, and the motor drives the centrifuge cylinder to rotate at high speed for a period of time through the guide shaft. After the centrifuge cylinder rotates at high speed, the hyaluronic acid dressing in the centrifuge cylinder is layered by centrifugal force and filtered out by the centrifugal filter membrane. The final hyaluronic acid dressing material, the filtered hyaluronic acid dressing enters the bottom of the centrifugal cylinder, and after the motor is powered on for a period of time, the motor is powered off;

步骤(4)、电机断电的同时,将电磁铁通电,电磁铁通电后不断吸附旋转的铁片,最终使铁片吸附在电磁铁最上方,离心筒停止,且此时,离心筒的出药口正好对准接料槽;Step (4), while the motor is powered off, power on the electromagnet. After the electromagnet is powered on, the rotating iron piece is continuously adsorbed, and finally the iron piece is adsorbed on the top of the electromagnet, and the centrifugal cylinder stops. At this time, the centrifugal cylinder exits The drug mouth is just aligned with the receiving trough;

步骤(5)、待离心机最终停下的一刻,电动伸缩杆通电,电动伸缩杆支撑离心筒向上移动一段距离;Step (5), when the centrifuge finally stops, the electric telescopic rod is energized, and the electric telescopic rod supports the centrifugal cylinder to move upward for a certain distance;

步骤(5-1)、此时打开出药口处的电磁阀过或者出药堵头,将离心筒内离心后的透明质酸敷料倒入相应的接料槽内;Step (5-1), at this time, open the solenoid valve at the drug outlet or the drug outlet plug, and pour the hyaluronic acid dressing centrifuged in the centrifuge cylinder into the corresponding receiving tank;

步骤(6)、最后取出接料槽,电动伸缩杆通电下降至最低位,使离心筒底部重新与磁性限位盘磁性吸附,完成一个离心循环,可按照步骤(1)-步骤(6)离心加工另一批透明质酸敷料;Step (6), finally take out the receiving trough, power on the electric telescopic rod and lower it to the lowest position, so that the bottom of the centrifuge cylinder is magnetically adsorbed to the magnetic limit plate again, and a centrifugal cycle is completed, which can be centrifuged according to steps (1)-step (6) Processing another batch of hyaluronic acid dressing;

步骤(6-1)、离心结束后,可继续将电动伸缩杆通电,电动伸缩杆支撑离心筒离开磁性限位盘;然后将离心筒从导向轴上取出,并打开离心筒上下两侧的注药口和出药口,清洗离心筒内部所述磁性限位盘与离心筒底部磁性吸引。Step (6-1), after the centrifugation is completed, continue to power on the electric telescopic rod, and the electric telescopic rod supports the centrifuge cylinder away from the magnetic limit plate; then take the centrifuge cylinder out of the guide shaft, and open the injection valves on the upper and lower sides of the centrifuge cylinder. Drug port and drug outlet, clean the magnetic limit plate inside the centrifuge cylinder and magnetically attract the bottom of the centrifuge cylinder.

进一步地,步骤(2)中,将离心程度高,需要大离心力的透明质酸敷料放入大直径的离心筒内,将离心程度低,需要小离心力的透明质酸敷料放入小直径的离心筒内;步骤(3)中,电机通电时间根据透明质酸敷料离心时间进行设定。Furthermore, in step (2), put the hyaluronic acid dressing with a high degree of centrifugation and requires a large centrifugal force into a large-diameter centrifuge cylinder, and put the hyaluronic acid dressing with a low degree of centrifugation and requires a small centrifugal force into a centrifuge with a small diameter. In the barrel; in step (3), the power-on time of the motor is set according to the centrifugation time of the hyaluronic acid dressing.

本发明的有益效果:Beneficial effects of the present invention:

1、本发明的离心机构用于对不同离心程度的透明质酸敷料离心提纯,离心机构包括离心筒和离心滤膜,离心筒套设在导向轴上,离心滤膜设置在离心筒内,离心滤膜的加入使得离心后的透明质酸敷料再一次进行过滤分层,以起到提纯过滤其中杂质的效果;1. The centrifugal mechanism of the present invention is used for centrifugal purification of hyaluronic acid dressings with different centrifugal degrees. The centrifugal mechanism includes a centrifugal cylinder and a centrifugal filter membrane. The centrifugal cylinder is sleeved on the guide shaft, and the centrifugal filter membrane is arranged in the centrifugal cylinder. The addition of the filter membrane allows the hyaluronic acid dressing to be filtered and layered again after centrifugation, so as to purify and filter the impurities;

2、本发明的离心筒设有若干个,每个离心筒的直径不同,若干个离心筒采用同心圆式叠加套设;此设计使得在同一转速下,根据离心力公式F=mω2r其中ω表示非惯性系自身转动的角速度,r表示旋转半径,m表示物体的质量,可以看出,相同质量m和角速度ω情况下,离心力F与旋转半径r呈正线性相关,因此,不同半径的离心筒可以得到不同的离心力;2. There are several centrifugal cylinders of the present invention, each of which has a different diameter, and several centrifugal cylinders are superimposed and sleeved in concentric circles; this design makes it possible to use the centrifugal force formula F=mω 2 r where ω Represents the angular velocity of the non-inertial system's own rotation, r represents the radius of rotation, and m represents the mass of the object. It can be seen that under the same mass m and angular velocity ω, the centrifugal force F has a positive linear correlation with the radius of rotation r. Therefore, centrifugal cylinders with different radii Different centrifugal forces can be obtained;

3、本发明的锁止机构用于驱动离心机构转动;通过电机带动离心筒进行高速离心转动,导向轴的设计便于离心筒的拆卸;3. The locking mechanism of the present invention is used to drive the centrifugal mechanism to rotate; the centrifugal cylinder is driven by the motor to perform high-speed centrifugal rotation, and the design of the guide shaft facilitates the disassembly of the centrifugal cylinder;

4、本发明的支撑机构用于对离心筒上下支撑移动,支撑机构为一个电动伸缩杆,电动伸缩杆至少设置三个,每个电动伸缩杆等间距地分布在支撑托盘上表面,通过电动伸缩杆上下移动,支撑离心筒上下移动,方便离心筒内的透明质酸敷料的导出;4. The support mechanism of the present invention is used to support and move the centrifuge cylinder up and down. The support mechanism is an electric telescopic rod, and at least three electric telescopic rods are provided. The rod moves up and down, supports the centrifuge cylinder to move up and down, and facilitates the export of the hyaluronic acid dressing in the centrifuge cylinder;

5、本发明结构合理,采用全新的分级离心筒,根据不同半径的离心筒调试出合适离心程度的透明质酸敷料,可快速分离出不同离心程度的透明质酸敷料,另外本发明的装置省去了复杂的导料组件,方便透明质酸敷料的导出,使用方便高效。5. The present invention has a reasonable structure, adopts a brand-new grading centrifuge cylinder, adjusts hyaluronic acid dressings with a suitable centrifugal degree according to centrifugal cylinders with different radii, and can quickly separate hyaluronic acid dressings with different centrifugation degrees. In addition, the device of the present invention saves The complex material guide components are removed, which facilitates the export of hyaluronic acid dressings, and is convenient and efficient to use.

附图说明Description of drawings

通过阅读参照以下附图对非限制性实施例所作的详细描述,本发明的其它特征、目的和优点将会变得更明显:Other characteristics, objects and advantages of the present invention will become more apparent by reading the detailed description of non-limiting embodiments made with reference to the following drawings:

图1为本发明一种透明质酸敷料离心提纯装置的结构示意图;Fig. 1 is the structural representation of a kind of hyaluronic acid dressing centrifugal purification device of the present invention;

图2为本发明一种透明质酸敷料离心提纯装置的正视剖面图;Fig. 2 is the front section view of a hyaluronic acid dressing centrifugal purification device of the present invention;

图3为本发明一种透明质酸敷料离心提纯装置的左视剖面图;Fig. 3 is a left view sectional view of a hyaluronic acid dressing centrifugal purification device of the present invention;

图4为本发明一种透明质酸敷料离心提纯装置中离心滤膜的结构示意图;Fig. 4 is a structural schematic diagram of a centrifugal filter membrane in a hyaluronic acid dressing centrifugal purification device of the present invention;

图5为本发明一种透明质酸敷料离心提纯装置中导向轴的结构示意图;Fig. 5 is a structural schematic diagram of a guide shaft in a hyaluronic acid dressing centrifugal purification device of the present invention;

图中:1离心机构、11离心筒、12注药口、13液位计、14离心滤膜、15出药口、16配重块、21支撑托盘、22接料槽、3驱动机构、31电机、32磁性限位盘、33导向轴、4锁止机构、41电磁铁、42铁片、5支撑机构。In the figure: 1 centrifugal mechanism, 11 centrifugal cylinder, 12 drug injection port, 13 liquid level gauge, 14 centrifugal filter membrane, 15 drug outlet, 16 counterweight, 21 support tray, 22 receiving trough, 3 drive mechanism, 31 Motor, 32 magnetic limit discs, 33 guide shafts, 4 locking mechanisms, 41 electromagnets, 42 iron sheets, 5 supporting mechanisms.

具体实施方式Detailed ways

为使本发明实现的技术手段、创作特征、达成目的与功效易于明白了解,下面结合具体实施方式,进一步阐述本发明。In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments.

请参阅图1-图5,本发明提供一种技术方案:一种透明质酸敷料离心提纯装置,包括离心机构1、驱动机构3、锁止机构4、支撑机构5和支撑托盘21;解决了过去的透明质酸敷料不能够根据离心程度的需要进行分级提纯,离心后的透明质酸敷料导出过程复杂的问题。Please refer to Figures 1-5, the present invention provides a technical solution: a hyaluronic acid dressing centrifugal purification device, including a centrifugal mechanism 1, a driving mechanism 3, a locking mechanism 4, a supporting mechanism 5 and a supporting tray 21; In the past, hyaluronic acid dressings could not be graded and purified according to the degree of centrifugation, and the derivation process of hyaluronic acid dressings after centrifugation was complicated.

本发明的锁止机构4用于驱动离心机构1转动,锁止机构4包括电机31和导向轴33,电机31设置在支撑托盘21上,电机31的动力轴上设置有磁性限位盘32,导向轴33连接在电机31的动力轴上,导向轴33表面设置有齿牙,最内侧的离心筒11内侧开设有齿套,齿套与齿牙相匹配;通过电机31带动离心筒11进行高速离心转动,导向轴33的设计便于离心筒11的拆卸。The locking mechanism 4 of the present invention is used to drive the centrifugal mechanism 1 to rotate. The locking mechanism 4 includes a motor 31 and a guide shaft 33. The motor 31 is arranged on the support tray 21. The power shaft of the motor 31 is provided with a magnetic limiting disc 32. The guide shaft 33 is connected to the power shaft of the motor 31, the surface of the guide shaft 33 is provided with teeth, and the inside of the innermost centrifugal cylinder 11 is provided with a gear sleeve, which matches the teeth; the motor 31 drives the centrifugal cylinder 11 to perform high-speed Centrifugal rotation, the design of the guide shaft 33 facilitates the disassembly of the centrifugal cylinder 11.

本发明的离心机构1用于对不同离心程度的透明质酸敷料离心提纯,离心机构1包括离心筒11和离心滤膜14,离心筒11套设在导向轴33上,离心滤膜14设置在离心筒11内,离心滤膜14的加入使得离心后的透明质酸敷料再一次进行过滤分层,以起到提纯过滤其中杂质的效果;The centrifugal mechanism 1 of the present invention is used for the centrifugal purification of hyaluronic acid dressings with different centrifugal degrees. The centrifugal mechanism 1 includes a centrifugal cylinder 11 and a centrifugal filter membrane 14. The centrifugal cylinder 11 is sleeved on the guide shaft 33, and the centrifugal filter membrane 14 is arranged on the In the centrifuge cylinder 11, the addition of the centrifugal filter membrane 14 makes the centrifuged hyaluronic acid dressing filter and stratify again, so as to purify and filter impurities therein;

离心筒11设有若干个,每个离心筒11的直径不同,若干个离心筒11采用同心圆式叠加套设;此设计使得在同一转速下,根据离心力公式F=mω2r其中ω表示非惯性系自身转动的角速度,r表示旋转半径,m表示物体的质量,可以看出,相同质量m和角速度ω情况下,离心力F与旋转半径r呈正线性相关,因此,不同半径的离心筒11可以得到不同的离心力。There are several centrifugal cylinders 11, each of which has a different diameter, and several centrifugal cylinders 11 are superimposed and sleeved in concentric circles; this design makes it possible to use the centrifugal force formula F=mω 2 r at the same speed, where ω represents non The angular velocity of the inertial system’s own rotation, r represents the radius of rotation, and m represents the mass of the object. It can be seen that under the same mass m and angular velocity ω, the centrifugal force F has a positive linear correlation with the radius of rotation r. Therefore, centrifugal cylinders 11 with different radii can be get different centrifugal forces.

本发明的支撑机构5用于对离心筒11上下支撑移动,支撑机构5为一个电动伸缩杆,电动伸缩杆至少设置三个,每个电动伸缩杆等间距地分布在支撑托盘21上表面,通过电动伸缩杆上下移动,支撑离心筒11上下移动,方便离心筒11内的透明质酸敷料的导出。The support mechanism 5 of the present invention is used to support and move the centrifuge cylinder 11 up and down. The support mechanism 5 is an electric telescopic rod, and at least three electric telescopic rods are arranged. The electric telescopic rod moves up and down, supports the centrifugal cylinder 11 to move up and down, and facilitates the derivation of the hyaluronic acid dressing in the centrifugal cylinder 11.

本发明的离心筒11的顶部开设有注药口12,且注药口12贯穿设置有注药塞子,离心筒11的底部开设有出药口15,且出药口15贯穿设置有电磁阀或出药塞子,离心筒11的内部设置有配重块16,配重块16用于平衡离心筒11旋转时的离心力,防止离心筒11高速转动过程中手里不平衡,发生偏心旋转,影响离心筒11的正常旋转。The top of the centrifugal cylinder 11 of the present invention is provided with a drug injection port 12, and the drug injection port 12 is provided with a drug injection plug, and the bottom of the centrifugal cylinder 11 is provided with a drug outlet 15, and the drug outlet 15 is provided with a solenoid valve or The medicine plug, the inside of the centrifugal cylinder 11 is provided with a counterweight 16, the counterweight 16 is used to balance the centrifugal force when the centrifugal cylinder 11 rotates, and prevent the hand from being unbalanced during the high-speed rotation of the centrifugal cylinder 11, resulting in eccentric rotation and affecting the centrifugal force. Normal rotation of drum 11.

本发明的离心滤膜14为两个端面镂空的圆台结构,离心滤膜固定设置在离心筒11内,此设计为使高速旋转下的透明质酸敷料受离心力而穿过离心滤膜14进行过滤,进一步提高透明质酸敷料的纯度。The centrifugal filter membrane 14 of the present invention is a round platform structure with two hollowed-out ends, and the centrifugal filter membrane is fixedly arranged in the centrifugal cylinder 11. This design is to make the hyaluronic acid dressing under high-speed rotation be subjected to centrifugal force to pass through the centrifugal filter membrane 14 for filtration. , to further improve the purity of the hyaluronic acid dressing.

本发明的磁性限位盘32与离心筒11底部磁性吸引,防止离心筒11高速旋转时向上移动跳起。The magnetic limit plate 32 of the present invention is magnetically attracted to the bottom of the centrifugal cylinder 11 to prevent the centrifugal cylinder 11 from moving up and jumping up when rotating at high speed.

本发明的支撑托盘21上设置有若干个用于接收不同离心筒11内液体的接料槽22;The support tray 21 of the present invention is provided with several receiving troughs 22 for receiving liquids in different centrifugal cylinders 11;

支撑托盘21上设置有用于离心筒11定位停止的锁止机构4,锁止包括电磁铁41和铁片42,电磁铁41设置在支撑托盘21上,铁片42贴附在离心筒11下表面,铁片42的旋转面与电磁铁41的中心线重合,此设计使得离心筒11停止时,离心筒11的出药口15能够对准接料槽22导出透明质酸敷料。The support tray 21 is provided with a locking mechanism 4 for positioning and stopping the centrifugal cylinder 11. The locking mechanism includes an electromagnet 41 and an iron piece 42. The electromagnet 41 is arranged on the support tray 21, and the iron piece 42 is attached to the lower surface of the centrifugal cylinder 11. , the rotating surface of the iron sheet 42 coincides with the center line of the electromagnet 41, this design makes when the centrifuge cylinder 11 stops, the drug outlet 15 of the centrifuge cylinder 11 can be aligned with the material receiving groove 22 to lead out the hyaluronic acid dressing.

具体工作原理:首先将支撑托盘21放置在指定支撑平面上,将多个不同直径的离心筒11按照同心圆样式叠加套设,并最终套设成一个整体结构;并将该整体结构插入导向轴33上,离心筒11底部与磁性限位盘32磁性贴合;Specific working principle: First, place the support tray 21 on the designated support plane, stack and sleeve a plurality of centrifugal cylinders 11 with different diameters in a concentric circle pattern, and finally form a whole structure; insert the whole structure into the guide shaft 33, the bottom of the centrifugal cylinder 11 is magnetically attached to the magnetic limit plate 32;

然后打开离心筒11上的注药口12,向离心筒11内倒入待离心处理的透明质酸敷料,通过不断观察液位计13的读数,将指定体积的透明质酸敷料注入离心筒11内,液位计13到达指定体积读数后,盖紧注药口12;将离心程度高,需要大离心力的透明质酸敷料放入大直径的离心筒11内,将离心程度低,需要小离心力的透明质酸敷料放入小直径的离心筒11内;Then open the injection port 12 on the centrifuge cylinder 11, pour the hyaluronic acid dressing to be centrifuged into the centrifuge cylinder 11, and inject the hyaluronic acid dressing of the specified volume into the centrifuge cylinder 11 by constantly observing the reading of the liquid level gauge 13 Inside, after the liquid level gauge 13 reaches the specified volume reading, cover the injection port 12 tightly; put the hyaluronic acid dressing with a high degree of centrifugal force and requires a large centrifugal force into the large-diameter centrifugal cylinder 11, and put the hyaluronic acid dressing with a low degree of centrifugal force and requires a small centrifugal force The hyaluronic acid dressing is put into the centrifugal cylinder 11 of small diameter;

然后将电机31通电,电机31通过导向轴33带动离心筒11高速离心转动一段时间,离心筒11高速转动后,离心筒11内的透明质酸敷料经过离心力作用分层;根据离心力公式F=mω2r其中ω表示非惯性系自身转动的角速度,r表示旋转半径,m表示物体的质量,可以看出,相同质量m和角速度ω情况下,离心力F与旋转半径r呈正线性相关,因此,不同半径的离心筒11可以得到不同的离心力;Then the motor 31 is energized, and the motor 31 drives the centrifugal cylinder 11 to rotate at high speed for a period of time through the guide shaft 33. After the centrifugal cylinder 11 rotates at a high speed, the hyaluronic acid dressing in the centrifugal cylinder 11 is layered by centrifugal force; according to the centrifugal force formula F=mω 2 r where ω represents the angular velocity of the non-inertial system’s own rotation, r represents the radius of rotation, and m represents the mass of the object. It can be seen that under the same mass m and angular velocity ω, the centrifugal force F is positively linearly related to the rotation radius r, therefore, different The radius of the centrifugal cylinder 11 can obtain different centrifugal forces;

然后经过高速旋转下的透明质酸敷料受离心力而穿过离心滤膜14进行过滤,进一步提高透明质酸敷料的纯度,过滤后的透明质酸敷料进入离心筒11底部,电机31通电一段时间后,电机31通电时间根据透明质酸敷料离心时间进行设定,随后将电机31断电;Then the hyaluronic acid dressing under high-speed rotation is subjected to centrifugal force to pass through the centrifugal filter membrane 14 to filter, further improving the purity of the hyaluronic acid dressing, and the filtered hyaluronic acid dressing enters the bottom of the centrifugal cylinder 11, and after the motor 31 is energized for a period of time , the power-on time of the motor 31 is set according to the centrifugation time of the hyaluronic acid dressing, and then the motor 31 is powered off;

随后电机31断电的同时,将电磁铁41通电,电磁铁41通电后不断吸附旋转的铁片42,最终使铁片42吸附在电磁铁41最上方,离心筒11停止,且此时,离心筒11的出药口15正好对准接料槽22;Then when the motor 31 is powered off, the electromagnet 41 is energized. After the electromagnet 41 is energized, the iron sheet 42 is constantly adsorbed and rotated, and finally the iron sheet 42 is adsorbed on the top of the electromagnet 41, and the centrifugal drum 11 stops. At this time, the centrifugal The drug outlet 15 of the barrel 11 is just aligned with the receiving tank 22;

待离心机最终停下的一刻,电动伸缩杆通电,电动伸缩杆支撑离心筒11向上移动一段距离;此时打开出药口15处的电磁阀过或者出药堵头,将离心筒11内离心后的透明质酸敷料倒入相应的接料槽22内;最后取出接料槽22,电动伸缩杆通电下降至最低位,使离心筒11底部重新与磁性限位盘32磁性吸附,完成一个离心循环,可按照上述步骤离心加工另一批透明质酸敷料;The moment the centrifuge finally stops, the electric telescopic rod is energized, and the electric telescopic rod supports the centrifuge cylinder 11 to move upward for a certain distance; at this time, the solenoid valve at the medicine outlet 15 or the medicine discharge plug is opened, and the centrifuge cylinder 11 is centrifuged. The final hyaluronic acid dressing is poured into the corresponding material receiving tank 22; finally, the material receiving tank 22 is taken out, and the electric telescopic rod is energized and lowered to the lowest position, so that the bottom of the centrifuge cylinder 11 is magnetically adsorbed to the magnetic limit plate 32 again, and a centrifuge cycle is completed. cycle, another batch of hyaluronic acid dressing can be centrifuged according to the above steps;

最后离心结束后,可继续将电动伸缩杆通电,电动伸缩杆支撑离心筒11离开磁性限位盘32;然后将离心筒11从导向轴33上取出,并打开离心筒11上下两侧的注药口12。。Finally, after the centrifugation is completed, the electric telescopic rod can continue to be energized, and the electric telescopic rod supports the centrifugal cylinder 11 to leave the magnetic limit plate 32; Mouth 12. .

以上显示和描述了本发明的基本原理和主要特征和本发明的优点,对于本领域技术人员而言,显然本发明不限于上述示范性实施例的细节,而且在不背离本发明的精神或基本特征的情况下,能够以其他的具体形式实现本发明。因此,无论从哪一点来看,均应将实施例看作是示范性的,而且是非限制性的,本发明的范围由所附权利要求而不是上述说明限定,因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。不应将权利要求中的任何附图标记视为限制所涉及的权利要求。The basic principles and main features of the present invention and the advantages of the present invention have been shown and described above. For those skilled in the art, it is obvious that the present invention is not limited to the details of the above-mentioned exemplary embodiments, and without departing from the spirit or fundamentals of the present invention. The present invention can be implemented in other specific forms without any specific features. Accordingly, the embodiments should be regarded in all points of view as exemplary and not restrictive, the scope of the invention being defined by the appended claims rather than the foregoing description, and it is therefore intended that the scope of the invention be defined by the appended claims rather than by the foregoing description. All changes within the meaning and range of equivalents of the elements are embraced in the present invention. Any reference sign in a claim should not be construed as limiting the claim concerned.

此外,应当理解,虽然本说明书按照实施方式加以描述,但并非每个实施方式仅包含一个独立的技术方案,说明书的这种叙述方式仅仅是为清楚起见,本领域技术人员应当将说明书作为一个整体,各实施例中的技术方案也可以经适当组合,形成本领域技术人员可以理解的其他实施方式。In addition, it should be understood that although this specification is described according to implementation modes, not each implementation mode only includes an independent technical solution, and this description in the specification is only for clarity, and those skilled in the art should take the specification as a whole , the technical solutions in the various embodiments can also be properly combined to form other implementations that can be understood by those skilled in the art.

Claims (2)

1.一种透明质酸敷料离心提纯装置的使用方法,其特征在于:该透明质酸敷料离心提纯装置,包括离心机构(1)、驱动机构(3)、锁止机构(4)、支撑机构(5)和支撑托盘(21);1. A method for using a hyaluronic acid dressing centrifugal purification device, characterized in that: the hyaluronic acid dressing centrifugal purification device includes a centrifugal mechanism (1), a driving mechanism (3), a locking mechanism (4), a supporting mechanism (5) and support tray (21); 所述驱动机构(3)用于驱动离心机构(1)转动,所述驱动机构(3)包括电机(31)和导向轴(33),所述电机(31)设置在支撑托盘(21)上,所述电机(31)的动力轴上设置有磁性限位盘(32),所述导向轴(33)连接在电机(31)的动力轴上;The drive mechanism (3) is used to drive the centrifugal mechanism (1) to rotate, the drive mechanism (3) includes a motor (31) and a guide shaft (33), and the motor (31) is arranged on the support tray (21) , the power shaft of the motor (31) is provided with a magnetic limit disc (32), and the guide shaft (33) is connected to the power shaft of the motor (31); 所述离心机构(1)用于对不同离心程度的透明质酸敷料离心提纯,所述离心机构(1)包括离心筒(11)和离心滤膜(14),所述离心筒(11)套设在导向轴(33)上,所述离心滤膜(14)设置在离心筒(11)内,所述离心筒(11)上贯通设置有液位计(13);The centrifugal mechanism (1) is used for centrifugal purification of hyaluronic acid dressings with different centrifugal degrees, the centrifugal mechanism (1) includes a centrifugal cylinder (11) and a centrifugal filter membrane (14), and the centrifugal cylinder (11) covers Set on the guide shaft (33), the centrifugal filter membrane (14) is set in the centrifugal cylinder (11), and the liquid level gauge (13) is arranged through the centrifugal cylinder (11); 所述支撑机构(5)用于对离心筒(11)上下支撑移动,所述支撑机构(5)为一个电动伸缩杆;The support mechanism (5) is used to support and move the centrifuge cylinder (11) up and down, and the support mechanism (5) is an electric telescopic rod; 所述离心筒(11)设有若干个,每个离心筒(11)的直径不同,若干个离心筒(11)采用同心圆式叠加套设;There are several centrifuge cylinders (11), each of which has a different diameter, and several centrifuge cylinders (11) are stacked in concentric circles; 所述离心筒(11)的顶部开设有注药口(12),且注药口(12)贯穿设置有注药塞子,所述离心筒(11)的底部开设有出药口(15),且出药口(15)贯穿设置有电磁阀或出药塞子,所述离心筒(11)的内部设置有配重块(16),配重块(16)用于平衡离心筒(11)旋转时的离心力;The top of the centrifugal cylinder (11) is provided with a drug injection port (12), and a drug injection plug is provided through the drug injection port (12), and a drug outlet (15) is provided at the bottom of the centrifugal cylinder (11). And the drug outlet (15) is provided with a solenoid valve or a drug outlet plug, and the inside of the centrifugal cylinder (11) is provided with a counterweight (16), and the counterweight (16) is used to balance the rotation of the centrifugal cylinder (11) Centrifugal force at time; 所述离心滤膜(14)为两个端面镂空的圆台结构,所述离心滤膜(14)固定设置在离心筒(11)内;The centrifugal filter membrane (14) is a circular platform structure with two hollowed-out ends, and the centrifugal filter membrane (14) is fixedly arranged in the centrifugal cylinder (11); 所述磁性限位盘(32)与离心筒(11)底部磁性吸引;The magnetic limit plate (32) is magnetically attracted to the bottom of the centrifugal cylinder (11); 所述支撑托盘(21)上设置有若干个用于接收不同离心筒(11)内液体的接料槽(22),所述支撑托盘(21)上设置有用于离心筒(11)定位停止的锁止机构(4),所述锁止包括电磁铁(41)和铁片(42),所述电磁铁(41)设置在支撑托盘(21)上,所述铁片(42)贴附在离心筒(11)下表面,所述铁片(42)的旋转面与电磁铁(41)的中心线重合;The support tray (21) is provided with several receiving troughs (22) for receiving the liquids in different centrifugal cylinders (11), and the support tray (21) is provided with positioning stops for the centrifugal cylinders (11). A locking mechanism (4), the locking includes an electromagnet (41) and an iron sheet (42), the electromagnet (41) is set on the support tray (21), and the iron sheet (42) is attached to The lower surface of the centrifugal cylinder (11), the rotating surface of the iron sheet (42) coincides with the center line of the electromagnet (41); 所述电动伸缩杆至少设置三个,每个电动伸缩杆等间距地分布在支撑托盘(21)上表面;There are at least three electric telescopic rods, and each electric telescopic rod is equally spaced on the upper surface of the support tray (21); 所述导向轴(33)表面设置有齿牙,最内侧的离心筒(11)内侧开设有齿套,齿套与齿牙相匹配;The surface of the guide shaft (33) is provided with teeth, and the inside of the innermost centrifugal cylinder (11) is provided with a gear sleeve, and the gear sleeve matches the teeth; 该透明质酸敷料离心提纯装置的使用方法,包括如下步骤:The method for using the hyaluronic acid dressing centrifugal purification device comprises the following steps: 步骤(1)、支撑托盘(21)放置在指定支撑平面上,将多个不同直径的离心筒(11)按照同心圆样式叠加套设,并最终套设成一个整体结构;Step (1), the support tray (21) is placed on the designated support plane, and multiple centrifugal cylinders (11) with different diameters are superimposed and nested according to the concentric circle pattern, and finally nested into an overall structure; 步骤(1-1)、将步骤(1)中的整体结构插入导向轴(33)上,离心筒(11)底部与磁性限位盘(32)磁性贴合;Step (1-1), insert the overall structure in step (1) onto the guide shaft (33), and magnetically attach the bottom of the centrifugal cylinder (11) to the magnetic limit plate (32); 步骤(2)、打开离心筒(11)上的注药口(12),向离心筒(11)内倒入待离心处理的透明质酸敷料,通过不断观察液位计(13)的读数,将指定体积的透明质酸敷料注入离心筒(11)内,液位计(13)到达指定体积读数后,盖紧注药口(12);Step (2), open the injection port (12) on the centrifuge cylinder (11), pour the hyaluronic acid dressing to be centrifuged into the centrifuge cylinder (11), and continuously observe the reading of the liquid level gauge (13), Inject the specified volume of hyaluronic acid dressing into the centrifuge cylinder (11), and close the injection port (12) after the liquid level gauge (13) reaches the specified volume reading; 步骤(3)、将电机(31)通电,电机(31)通过导向轴(33)带动离心筒(11)高速离心转动一段时间,离心筒(11)高速转动后,离心筒(11)内的透明质酸敷料经过离心力作用分层,并经过离心滤膜(14)过滤出离心后的透明质酸敷料物质,过滤后的透明质酸敷料进入离心筒(11)底部,电机(31)通电一段时间后,将电机(31)断电;Step (3), power on the motor (31), the motor (31) drives the centrifuge cylinder (11) to rotate at high speed for a period of time through the guide shaft (33), after the centrifuge cylinder (11) rotates at high speed, the The hyaluronic acid dressing is layered by centrifugal force, and the centrifuged hyaluronic acid dressing material is filtered out through the centrifugal filter membrane (14). The filtered hyaluronic acid dressing enters the bottom of the centrifugal cylinder (11), and the motor (31) is energized for a period of time. After the time, the motor (31) is powered off; 步骤(4)、电机(31)断电的同时,将电磁铁(41)通电,电磁铁(41)通电后不断吸附旋转的铁片(42),最终使铁片(42)吸附在电磁铁(41)最上方,离心筒(11)停止,且此时,离心筒(11)的出药口(15)正好对准接料槽(22);Step (4), while the motor (31) is powered off, the electromagnet (41) is energized. After the electromagnet (41) is energized, the rotating iron piece (42) is continuously adsorbed, and finally the iron piece (42) is adsorbed on the electromagnet (41) At the top, the centrifuge cylinder (11) stops, and at this time, the drug outlet (15) of the centrifuge cylinder (11) is just aligned with the receiving tank (22); 步骤(5)、待离心机最终停下的一刻,电动伸缩杆通电,电动伸缩杆支撑离心筒(11)向上移动一段距离;Step (5), when the centrifuge finally stops, the electric telescopic rod is energized, and the electric telescopic rod supports the centrifuge cylinder (11) to move upward for a certain distance; 步骤(5-1)、此时打开出药口(15)处的电磁阀或者出药堵头,将离心筒(11)内离心后的透明质酸敷料倒入相应的接料槽(22)内;Step (5-1), at this time, open the solenoid valve at the drug outlet (15) or the drug outlet plug, and pour the hyaluronic acid dressing centrifuged in the centrifugal cylinder (11) into the corresponding receiving tank (22) Inside; 步骤(6)、最后取出接料槽(22),电动伸缩杆通电下降至最低位,使离心筒(11)底部重新与磁性限位盘(32)磁性吸附,完成一个离心循环,可按照步骤(1)-步骤(6)离心加工另一批透明质酸敷料;Step (6), finally take out the receiving tank (22), power on the electric telescopic rod and lower it to the lowest position, so that the bottom of the centrifuge cylinder (11) is magnetically adsorbed to the magnetic limit plate (32) again, and a centrifugal cycle is completed. (1)-step (6) centrifuge another batch of hyaluronic acid dressing; 步骤(6-1)、离心结束后,可继续将电动伸缩杆通电,电动伸缩杆支撑离心筒(11)离开磁性限位盘(32);然后将离心筒(11)从导向轴(33)上取出,并打开离心筒(11)上下两侧的注药口(12)和出药口(15),清洗离心筒(11)内部。Step (6-1), after the centrifugation is completed, continue to energize the electric telescopic rod, and the electric telescopic rod supports the centrifuge cylinder (11) away from the magnetic limit plate (32); then pull the centrifuge cylinder (11) from the guide shaft (33) Take it out, and open the injection port (12) and the drug outlet (15) on the upper and lower sides of the centrifugal cylinder (11), and clean the inside of the centrifugal cylinder (11). 2.根据权利要求1所述的一种透明质酸敷料离心提纯装置的使用方法,其特征在于:步骤(2)中,将离心程度高,需要大离心力的透明质酸敷料放入大直径的离心筒(11)内,将离心程度低,需要小离心力的透明质酸敷料放入小直径的离心筒(11)内;2. The method for using a hyaluronic acid dressing centrifugal purification device according to claim 1, characterized in that: in step (2), put the hyaluronic acid dressing with a high degree of centrifugal force and a large centrifugal force into the large-diameter In the centrifuge cylinder (11), put the hyaluronic acid dressing that has a low degree of centrifugation and requires small centrifugal force into the small diameter centrifuge cylinder (11); 步骤(3)中,电机(31)通电时间根据透明质酸敷料离心时间进行设定。In step (3), the power-on time of the motor (31) is set according to the centrifugation time of the hyaluronic acid dressing.
CN202111242815.7A 2021-10-25 2021-10-25 A kind of hyaluronic acid dressing centrifugal purification device and using method Active CN113996448B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111242815.7A CN113996448B (en) 2021-10-25 2021-10-25 A kind of hyaluronic acid dressing centrifugal purification device and using method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202111242815.7A CN113996448B (en) 2021-10-25 2021-10-25 A kind of hyaluronic acid dressing centrifugal purification device and using method

Publications (2)

Publication Number Publication Date
CN113996448A CN113996448A (en) 2022-02-01
CN113996448B true CN113996448B (en) 2023-06-02

Family

ID=79923901

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202111242815.7A Active CN113996448B (en) 2021-10-25 2021-10-25 A kind of hyaluronic acid dressing centrifugal purification device and using method

Country Status (1)

Country Link
CN (1) CN113996448B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115299384A (en) * 2022-09-14 2022-11-08 山东农业大学 An unmanned honey collection device and collection method for small complex bee farms
CN115569438A (en) * 2022-10-28 2023-01-06 重庆新纪信息技术服务有限公司 A centrifugal purification device for chemical raw materials and its application method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1237296A (en) * 1969-04-10 1971-06-30 Robert William Hooper Dynamic mixer and centrifuge combination
JP2018100771A (en) * 2017-12-12 2018-06-28 三井電気精機株式会社 Rotating body driving/seal structure and centrifugal separator including the same
CN210875822U (en) * 2019-10-17 2020-06-30 安徽赛而特离心机有限公司 Centrifuge screen cloth is convenient for change device
CN214327674U (en) * 2020-12-11 2021-10-01 楚雄三牧农业科技有限公司 Animal fat washing edulcoration device

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202620670U (en) * 2012-05-17 2012-12-26 浙江工业大学 Magnetic force-positioned rotary disc
CN102832846B (en) * 2012-09-01 2015-02-04 浙江师范大学 Shaft power generator based on axial flexural vibration of piezoelectric vibrator of cantilever beam
WO2015112772A1 (en) * 2014-01-22 2015-07-30 Theranos, Inc. High speed, compact centrifuge for use with small sample volumes
CN204422537U (en) * 2015-02-13 2015-06-24 南京天纵易康生物科技有限公司 With the immunochromatographiassays assays instrument of centrifugal device
CH712641A2 (en) * 2016-07-01 2018-01-15 Montres Breguet Sa Timepiece comprising a switching device of a mechanism of this part.
CN107374406A (en) * 2017-08-11 2017-11-24 徐佩登 A kind of separate type is beaten uniform anti-clogging soy bean milk making machine
CN107930868B (en) * 2017-11-21 2019-11-05 海南出入境检验检疫局检验检疫技术中心 A kind of supercentrifuge for food inspection
CN208641906U (en) * 2018-06-13 2019-03-26 山西山安碧泉海绵城市科技有限公司 A kind of sewage disposal device
CN208391933U (en) * 2018-06-20 2019-01-18 淄博威世能净油设备有限公司 A kind of centrifugal oil filter concentrator bowl disassembling fixture
CN208642973U (en) * 2018-06-27 2019-03-26 杭州威因太生物科技有限公司 Centrifugal drum is used in a kind of extraction of polypeptide
CN109225885A (en) * 2018-11-26 2019-01-18 嘉兴市名汇服饰有限公司 A kind of clothes processing button screening plant
CN109647635A (en) * 2018-12-18 2019-04-19 安徽国泰众信检测技术有限公司 A kind of centrifuge convenient for cleaning
CN109675726B (en) * 2019-01-28 2023-12-05 张家港市新华化工机械有限公司 Dual-filtration centrifugal machine
CN212652000U (en) * 2020-05-26 2021-03-05 朱文敏 Centrifuge is used in production of acid phase method chlorinated polyethylene
CN111889232A (en) * 2020-07-09 2020-11-06 湖州星创生态科技有限公司 Separation and purification device for alkaloid extraction
CN212975517U (en) * 2020-07-20 2021-04-16 唐山科澳化学助剂有限公司 A centrifugal equipment for antioxidant production
CN113462546A (en) * 2021-07-05 2021-10-01 梁明 Microbial separation verifying attachment

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1237296A (en) * 1969-04-10 1971-06-30 Robert William Hooper Dynamic mixer and centrifuge combination
JP2018100771A (en) * 2017-12-12 2018-06-28 三井電気精機株式会社 Rotating body driving/seal structure and centrifugal separator including the same
CN210875822U (en) * 2019-10-17 2020-06-30 安徽赛而特离心机有限公司 Centrifuge screen cloth is convenient for change device
CN214327674U (en) * 2020-12-11 2021-10-01 楚雄三牧农业科技有限公司 Animal fat washing edulcoration device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
基于多相流耦合过程数值模拟的茶鲜叶离心式连续脱水设备参数模拟与优化;朱志楠;赵章风;钟江;周仁桂;张宪;;茶叶科学(03);全文 *

Also Published As

Publication number Publication date
CN113996448A (en) 2022-02-01

Similar Documents

Publication Publication Date Title
CN113996448B (en) A kind of hyaluronic acid dressing centrifugal purification device and using method
CN103194390B (en) Double-loop oscillation perfusion-type biological reaction system
EP1648999A2 (en) Systems and methods for separating and concentrating regenerative cells from tissue
CN1896263A (en) Extraction of polysialic acid from polysialic-acid escherichia coli fermented broth
CN102732586A (en) A kind of culture method of mesenchymal stem cell secretin
CN101914438A (en) A rotating tubular cell/tissue culture system assisted by low-intensity pulsed ultrasound
CN103342748B (en) Special extraction device for main ingredient collagen II of natural cartilage matrix
CN103961797A (en) Method for promoting secretion of snail mucus and extraction method thereof
JPH02131154A (en) Biological cell centrifuge device and cell separation method
WO2011150726A1 (en) Stem cell filtering screening enrichment and quickly compounding device
CN108479177A (en) A kind of separator for extracting blood platelet from whole blood
CN103484356B (en) Fermentation reactor and preparation method for dynamically culturing and preparing ordered bacteria cellulose
CN111635860B (en) A system and culture method for stem cell culture
KR101650222B1 (en) Method for dissolving hyaluronic acid and/or a salt thereof
CN1290742A (en) Threed-dimensional stress adjustable rotary cell/tissue cultivator and its cultivating method
CN212955130U (en) Multistage centrifugal stem cell preparation facilities of high extraction rate
CN112029679A (en) A kind of large-scale culture method of Helicobacter pylori
CN207838421U (en) A kind of bio-pharmaceuticals extracting solution filter device
CN1131303C (en) Three-dimensional discal rotary hollow on-line cell cultivator with air and liquid supply
CN113731523B (en) Experiment table for extracting heparin sodium crude product
CN110872562B (en) Extracellular vesicle batch production device
CN219363660U (en) Lymphocyte culture device
CN208081875U (en) A kind of separate type evaporator for bio-pharmaceuticals
CN101385874B (en) Preparation method of biology synovial fluid containing polymer hyaluronic acid
JP7526384B2 (en) Cell Culture Substrate

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant