CN113975193A - Freeze-dried mask and preparation method thereof - Google Patents
Freeze-dried mask and preparation method thereof Download PDFInfo
- Publication number
- CN113975193A CN113975193A CN202111338940.8A CN202111338940A CN113975193A CN 113975193 A CN113975193 A CN 113975193A CN 202111338940 A CN202111338940 A CN 202111338940A CN 113975193 A CN113975193 A CN 113975193A
- Authority
- CN
- China
- Prior art keywords
- freeze
- mask
- dried
- base cloth
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000000047 product Substances 0.000 claims abstract description 23
- 238000001035 drying Methods 0.000 claims abstract description 22
- 239000004744 fabric Substances 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 21
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 18
- 229930195725 Mannitol Natural products 0.000 claims abstract description 18
- 239000000594 mannitol Substances 0.000 claims abstract description 18
- 235000010355 mannitol Nutrition 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 18
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 17
- 239000001913 cellulose Substances 0.000 claims abstract description 17
- 229920002678 cellulose Polymers 0.000 claims abstract description 17
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 17
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 17
- 239000002904 solvent Substances 0.000 claims abstract description 17
- 238000000859 sublimation Methods 0.000 claims abstract description 16
- 230000008022 sublimation Effects 0.000 claims abstract description 16
- UEJYSALTSUZXFV-SRVKXCTJSA-N Rigin Chemical compound NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O UEJYSALTSUZXFV-SRVKXCTJSA-N 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 14
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229930182555 Penicillin Natural products 0.000 claims abstract description 9
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims abstract description 9
- 229940049954 penicillin Drugs 0.000 claims abstract description 9
- -1 octapeptide-3 Chemical compound 0.000 claims abstract description 7
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 6
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 6
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 6
- 102000008186 Collagen Human genes 0.000 claims abstract description 5
- 108010035532 Collagen Proteins 0.000 claims abstract description 5
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims abstract description 5
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 5
- 229960001948 caffeine Drugs 0.000 claims abstract description 5
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229920001436 collagen Polymers 0.000 claims abstract description 5
- 238000001816 cooling Methods 0.000 claims abstract description 5
- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical compound CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 claims abstract description 5
- 239000011265 semifinished product Substances 0.000 claims abstract description 4
- 239000004373 Pullulan Substances 0.000 claims description 12
- 229920001218 Pullulan Polymers 0.000 claims description 12
- 235000019423 pullulan Nutrition 0.000 claims description 12
- 238000011049 filling Methods 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 244000005700 microbiome Species 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 abstract description 17
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 8
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 8
- 239000000203 mixture Substances 0.000 abstract description 6
- 239000003755 preservative agent Substances 0.000 abstract description 6
- 230000000172 allergic effect Effects 0.000 abstract description 3
- 208000010668 atopic eczema Diseases 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 3
- 230000000249 desinfective effect Effects 0.000 abstract description 3
- WQXNXVUDBPYKBA-UHFFFAOYSA-N Ectoine Natural products CC1=NCCC(C(O)=O)N1 WQXNXVUDBPYKBA-UHFFFAOYSA-N 0.000 abstract 1
- 230000001815 facial effect Effects 0.000 description 22
- 238000004108 freeze drying Methods 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 210000003491 skin Anatomy 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- 229920001184 polypeptide Polymers 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 244000181025 Rosa gallica Species 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- 239000008274 jelly Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 239000012856 weighed raw material Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 244000125300 Argania sideroxylon Species 0.000 description 1
- 235000016108 Argania sideroxylon Nutrition 0.000 description 1
- KNFLNGRLKALWRF-LDXSYGEZSA-N CSCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)CC1=CC=CC=C1 Chemical compound CSCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)CC1=CC=CC=C1 KNFLNGRLKALWRF-LDXSYGEZSA-N 0.000 description 1
- 241001523681 Dendrobium Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241001506047 Tremella Species 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- BJRNKVDFDLYUGJ-ZIQFBCGOSA-N alpha-Arbutin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-ZIQFBCGOSA-N 0.000 description 1
- 229940033280 alpha-arbutin Drugs 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940057070 sugarcane extract Drugs 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- 229940074410 trehalose Drugs 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a freeze-dried mask and a preparation method thereof, wherein the mask consists of sodium hyaluronate, hydrolyzed collagen, nicotinamide, trehalose, ectoine mannitol, cellulose, oligopeptide-1, hexapeptide-8, tetrapeptide-7, octapeptide-3, caffeine and a solvent. The preparation method comprises the steps of disinfecting the mask base cloth, folding the mask base cloth according to a fixed folding method, and putting the mask base cloth into a penicillin bottle filled with a material body; fully absorbing the full material body by the mask base cloth; pushing the processed semi-finished product into a freeze dryer, quickly cooling to-42 to-48 ℃, and starting to vacuumize for sublimation drying after the base cloth and the material body in the bottle are completely crystallized; the technical scheme of the invention overcomes the defect that functional components such as peptides are easy to inactivate in a liquid environment; preservatives must be added in a liquid state, so that the skin is irritated and allergic; and product composition and instability problems in liquid form; the active raw materials of the product are stable and effective, unnecessary preservatives and the like are avoided, and the product is more friendly to skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a freeze-dried mask and a preparation method thereof.
Background
The facial mask temporarily isolates outside air and pollution by using a short time of covering the facial mask, the skin temperature is increased, pores of the skin are expanded, the secretion and metabolism of sweat glands are promoted, the oxygen content of the skin is increased, the skin is favorable for removing products of metabolism of epidermal cells and accumulated grease substances, moisture in the facial mask permeates into the horny layer of the epidermis, the skin becomes soft, and the skin is naturally bright and elastic.
In order to increase the functions of the facial mask and meet the requirements of different consumer groups, in the technical field, the efficacy and the quality of the facial mask are improved by changing raw materials, improving the formula and changing the preparation process.
The facial mask mainly has four types, namely a paste type, a tearing type, a jelly type and a wet tissue type. The mud paste type facial mask is commonly an alga facial mask, a mud facial mask and the like, the tear type facial mask is the nasal paste special for blackheads, the jelly type is the best known as a sleep facial mask, and the wet tissue type is generally a facial mask paper which is packaged by a single sheet and is soaked with beauty treatment liquid. With the development of beauty science, a facial mask made of silk has appeared, and strictly speaking, it should be included in a wet tissue type facial mask.
In the prior art, the invention with the publication number of CN109260048A discloses a preparation method of a freeze-dried lozenge mask containing rHSA/EGF and an invention patent application of a using method, and the preparation method comprises the following steps: preparing rHSA/EGF freeze-dried tablets, namely weighing and dissolving auxiliary materials, adding rHSA/EGF into the auxiliary material solution, filtering by using a filter with the pore diameter of 0.45 micrometer, filling filtrate, and freeze-drying; b. preparing a mask paste: weighing the facial mask paste raw materials, dissolving, filtering with a filter with a pore size of 0.45 micrometer, plugging the facial mask towel into a facial mask bottle, and filling the filtered feed liquid into the facial mask bottle. The using method comprises the following steps: taking out an rHSA/EGF freeze-dried ingot; pouring out a proper amount of facial mask liquid to dissolve the rHSA/EGF freeze-dried ingot; uniformly smearing the dissolved rHSA/EGF on the face; the facial mask is applied to the face and removed after 15-20 minutes. The technical scheme designs a freeze-drying method aiming at a facial mask taking rHSA/EGF as a raw material.
The publication number CN111632005A discloses a polypeptide freeze-dried powder mask composition and a preparation and use method thereof, and discloses a mask, and the key points of the technical scheme are that the polypeptide freeze-dried powder mask composition consists of polypeptide freeze-dried powder, freeze-dried solvent, mask liquid and mask cloth; the polypeptide freeze-dried powder is prepared from the following raw materials: mannitol, trehalose, glycine, creatine, alpha-arbutin, tranexamic acid, ascorbic acid, mandelic acid, cortex magnoliae officinalis extract, nonapeptide-1, oligopeptide-5, oligopeptide-1, lecithin and the balance of water; the mask liquid is prepared from the following raw materials: polyglycerol-10, plant soothing agent, dendrobium extract, argania spinosa kernel oil, preservative composition, carbomer, triethanolamine, sugarcane extract, hydroxyethyl cellulose, tremella extract, hydrogenated castor oil, essential oil of rosa damascena, and the balance being made up by using rosa damascena hydrolat. The mask product in the technical scheme consists of polypeptide freeze-dried powder, freeze-dried solvent, mask liquid and mask cloth.
The publication number CN112006920A discloses a one-stage dynamic freeze-drying method for a freeze-drying facial mask, which relates to the technical field of freeze drying and solves the problems of low freeze-drying treatment efficiency and poor freeze-drying treatment effect. The technical key point is that the one-stage dynamic freeze-drying method of the freeze-dried mask comprises the following steps: preparing a mask liquid; spraying a mask liquid; freeze drying; and (6) packaging. And a proper cooling and freeze-drying program is set for the mask carrier, so that the temperature of the mask carrier is dynamically changed in the freezing tunnel, and the active substances of the mask are retained in a most proper mode under the condition that the concentration and the vacuum degree of a material system are not changed, thereby achieving the advantages of high freeze-drying treatment efficiency and good freeze-drying treatment effect. The technical scheme is characterized in that the method is dynamically completed in a freezing tunnel so as to retain active substances of the method.
In the prior art, technical problems generally to be faced and solved in mask skin care products include:
functional components such as peptides and the like are easy to inactivate in a liquid environment;
preservatives must be added in a liquid state, so that the skin is irritated and allergic;
product composition in liquid form and instability;
therefore, aiming at the technical problems in the prior art, a reasonable technical scheme is researched, the problems in the prior art are overcome, and the objective requirement is met.
Disclosure of Invention
In order to overcome the defects of the existing skin care products, the invention aims to provide a freeze-dried mask; the invention also aims to provide the moisturizing mask and the preparation method thereof.
The invention relates to a moisture-preserving and hydrating mask which is realized by the following technical scheme.
The freeze-dried mask disclosed by the invention consists of sodium hyaluronate, hydrolyzed collagen, nicotinamide, trehalose, ectoin mannitol, cellulose, oligopeptide-1, hexapeptide-8, tetrapeptide-7, octapeptide-3, caffeine and a solvent.
In the technical scheme of the invention, the components are counted by weight parts, and the total parts in the scheme are 100 parts by weight;
further, in a preferred embodiment of the technical solution of the present invention, the freeze-dried mask comprises: 0.16-0.24 part of sodium hyaluronate, 0.6-1.4 parts of mannitol, 0.3-0.7 part of pullulan, 0.25-0.45 part of cellulose, 0.06-0.14 part of hexapeptide-8, 0.08-0.16 part of tetrapeptide-7 and 0.06-0.14 part of octapeptide-3; the balance of solvent; the total weight part is 100 parts;
further, in a more preferred embodiment of the present invention, the freeze-dried mask comprises: 0.18-0.22 part of sodium hyaluronate, 0.8-1.2 parts of mannitol, 0.4-0.6 part of pullulan, 0.3-0.4 part of cellulose, 0.08-0.12 part of hexapeptide-8, 0.10-0.14 part of tetrapeptide-7 and 0.08-0.12 part of octapeptide-3; the balance of solvent; the total weight part is 100 parts;
further, in a most preferred embodiment of the present invention, the freeze-dried mask comprises: 0.2 part of sodium hyaluronate, 1 part of mannitol, 0.5 part of pullulan, 0.35 part of cellulose, 80.1 parts of hexapeptide, 70.12 parts of tetrapeptide and 30.1 parts of octapeptide; the balance of solvent; the total weight portion is 100 portions.
In the technical scheme of the invention, the solvent is low-carbon alcohol, such as ethanol, propanol, ethylene glycol and the like, or water, and the water is distilled water, deionized water or purified water.
The preparation method of the freeze-dried mask in the technical scheme of the invention comprises the following steps:
1. preparing sodium hyaluronate, hydrolyzed collagen, nicotinamide, trehalose, ectoin mannitol, cellulose, oligopeptide-1, hexapeptide-8, tetrapeptide-7, octapeptide-3, caffeine and other raw materials into an aqueous solution according to a proportion;
2. after washing 15ml of penicillin bottles, drying and sterilizing, filling 10ml of material;
3. disinfecting the mask base cloth, folding according to a fixed folding method, and putting into a penicillin bottle filled with a material body;
4. standing for 30 minutes until the mask base cloth fully absorbs the full body;
5. pushing the processed semi-finished product into a freeze dryer, quickly cooling to-42 to-48 ℃, and keeping for 1.8 to 2.4 hours;
6. after the base cloth and the material body in the bottle are completely crystallized, vacuumizing and carrying out sublimation drying;
7. the sublimation drying time is 15-22 hours, and air is discharged out of the box after the drying is finished;
8. and (3) quickly capping the freeze-dried product, sampling and inspecting, detecting the moisture content and the microorganism, and packaging the product of the batch for sale after the detection is qualified.
Preferably, the freeze dryer is rapidly cooled to-44 to-46 ℃ and kept for 1.9 to 2.2 hours; more preferably, the temperature is rapidly reduced to-45 ℃ and maintained for 2 hours.
Preferably, the sublimation drying time is 16.5 to 20 hours; more preferably, the sublimation drying time is 18 hours.
According to the technical scheme, the raw material solution is fully absorbed by the mask base cloth in a penicillin bottle, and then the mask base cloth is subjected to freeze drying and low-pressure sublimation drying, the raw material is adsorbed on the mask base cloth in a special mode, and a consumer can cover the face for a certain time by wetting the mask base cloth with water when using the mask base cloth.
Compared with the prior art, the method overcomes the defect that functional components such as peptides are easy to inactivate in a liquid environment; preservatives must be added in a liquid state, so that the skin is irritated and allergic; and product composition and instability problems in liquid form; the active raw materials of the product are stable and effective, unnecessary preservatives and the like are avoided, and the product is more friendly to skin.
In order to make the purpose and technical solution of the embodiments of the present invention clearer, the technical solution of the embodiments of the present invention will be clearly and completely described below with reference to the implementation examples of the embodiments of the present invention. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be made by a person skilled in the art without inventive effort based on the described embodiments of the invention, fall within the scope of protection of the invention.
Detailed Description
The technical solution of the present invention is further illustrated by the following specific examples. In the following specific examples, each raw material was obtained from the market unless otherwise specified.
The raw materials are all commercial products purchased from related production enterprises or commercial departments.
Example 1
In this example 1, raw materials, 0.2 kg of sodium hyaluronate, 1 kg of mannitol, 0.5 kg of pullulan, 0.35 kg of cellulose, 0.1 kg of hexapeptide-8, 0.12 kg of tetrapeptide-7, and 0.1 kg of octapeptide-3, were weighed in order; the solution was prepared with 97.63 kg of solvent water. The freeze-dried mask product was prepared as follows:
the freeze-dried mask is prepared from the weighed raw materials according to the following steps:
1. preparing weighed raw materials such as sodium hyaluronate, mannitol, pullulan, cellulose, hexapeptide-8, tetrapeptide-7, octapeptide-3 and the like into an aqueous solution;
2. after washing 15ml of penicillin bottles, drying and sterilizing, filling 10ml of material;
3. disinfecting the mask base cloth, folding according to a fixed folding method, and putting into a penicillin bottle filled with a material body;
4. standing for 30 minutes until the mask base cloth fully absorbs the full body;
5. pushing the processed semi-finished product into a freeze dryer, quickly cooling to-45 ℃, and keeping for 2 hours;
6. after the base cloth and the material body in the bottle are completely crystallized, vacuumizing for 25pa to carry out sublimation drying;
7. the sublimation drying time is 20 hours, and air is discharged out of the box after the drying is finished;
8. and (3) quickly capping the freeze-dried product, sampling and inspecting, detecting the moisture content and the microorganism, and packaging the product of the batch for sale after the detection is qualified.
Example 2
In this example 2, the following raw materials were weighed in sequence: 0.18 kg of sodium hyaluronate, 0.8 kg of mannitol, 0.4 kg of pullulan, 0.3 kg of cellulose, 0.08 kg of hexapeptide-8, 0.10 kg of tetrapeptide-7 and 0.08 kg of octapeptide-3; the solution was prepared with 98.06 kg of solvent water. The freeze-dried mask product was prepared as follows.
The freeze-dried mask was prepared according to the method of example 1, except that the freeze dryer was rapidly cooled to-48 ℃ for 1.8 hours; vacuum was applied for 45pa for sublimation drying for 22 hours.
Example 3
In this example 3, the following raw materials were weighed in sequence: 0.22 kg of sodium hyaluronate, 1.2 kg of mannitol, 0.6 kg of pullulan, 0.4 kg of cellulose, 0.12 kg of hexapeptide-8, 0.14 kg of tetrapeptide-7 and 0.12 kg of octapeptide-3; the solution was prepared with 98.06 kg of solvent water. The freeze-dried mask product was prepared as follows.
The freeze-dried mask was prepared according to the method of example 1, except that the freeze dryer was rapidly cooled to-46 ℃ for 1.9 hours; vacuum was applied for 40pa for sublimation drying for 20 hours.
Example 4
In this example 4, the following raw materials were weighed: 0.16 kg of sodium hyaluronate, 0.6 kg of mannitol, 0.3 kg of pullulan, 0.25 kg of cellulose, 0.06 kg of hexapeptide-8, 0.08 kg of tetrapeptide-7 and 0.06 kg of octapeptide-3; 100 kg of solution was made up with solvent water. The freeze-dried mask product was prepared as follows.
The freeze-dried mask was prepared according to the method of example 1, except that the freeze dryer was rapidly cooled to-48 ℃ for 2.1 hours; vacuum was applied for 30pa for sublimation drying for 22 hours.
Example 5
In this example 5, the following raw materials were weighed: 0.24 kg of sodium hyaluronate, 1.4 kg of mannitol, 0.7 kg of pullulan, 0.45 kg of cellulose, 0.14 kg of hexapeptide-8, 0.16 kg of tetrapeptide-7 and 0.14 kg of octapeptide-3; 100 kg of solution was made up with solvent water. The freeze-dried mask product was prepared as follows.
The freeze-dried mask was prepared according to the method of example 1, except that the freeze dryer was rapidly cooled to-46 ℃ for 2.0 hours; vacuum was applied for 40pa for sublimation drying for 22 hours.
The above description further describes a specific embodiment of the present invention with reference to specific examples, which are intended for the detailed description of the present invention and are not intended to limit the present invention. The above-mentioned embodiments are merely descriptions of the preferred embodiments of the present invention, and do not limit the technical concept and the protection scope of the present invention, and various modifications and improvements made to the technical concept by those skilled in the art without departing from the design concept of the present invention shall fall within the protection scope of the present invention.
Claims (9)
1. A freeze-dried mask is characterized by comprising sodium hyaluronate, hydrolyzed collagen, nicotinamide, trehalose, ectoin mannitol, cellulose, oligopeptide-1, hexapeptide-8, tetrapeptide-7, octapeptide-3, caffeine and a solvent.
2. The freeze-dried mask according to claim 1, wherein the freeze-dried mask comprises, in parts by weight: 0.16-0.24 part of sodium hyaluronate, 0.6-1.4 parts of mannitol, 0.3-0.7 part of pullulan, 0.25-0.45 part of cellulose, 0.06-0.14 part of hexapeptide-8, 0.08-0.16 part of tetrapeptide-7 and 0.06-0.14 part of octapeptide-3; the balance of solvent; the total weight portion is 100 portions.
3. The freeze-dried mask according to claim 2, wherein the freeze-dried mask comprises, in parts by weight: 0.18-0.22 part of sodium hyaluronate, 0.8-1.2 parts of mannitol, 0.4-0.6 part of pullulan, 0.3-0.4 part of cellulose, 0.08-0.12 part of hexapeptide-8, 0.10-0.14 part of tetrapeptide-7 and 0.08-0.12 part of octapeptide-3; the balance of solvent; the total weight portion is 100 portions.
4. The freeze-dried mask according to claim 3, wherein the freeze-dried mask comprises, in parts by weight: 0.2 part of sodium hyaluronate, 1 part of mannitol, 0.5 part of pullulan, 0.35 part of cellulose, 80.1 parts of hexapeptide, 70.12 parts of tetrapeptide and 30.1 parts of octapeptide; the balance of solvent; the total weight portion is 100 portions.
5. A preparation method of a freeze-dried mask is characterized by comprising the following steps:
1) preparing sodium hyaluronate, hydrolyzed collagen, nicotinamide, trehalose, ectoin mannitol, cellulose, oligopeptide-1, hexapeptide-8, tetrapeptide-7, octapeptide-3, caffeine and other raw materials into an aqueous solution according to a proportion;
2) washing 15ml of penicillin bottles, drying and sterilizing, and filling 10ml of penicillin bottles;
3) sterilizing the mask base cloth, folding according to a fixed folding method, and putting into a penicillin bottle filled with a material body;
4) standing for 30 minutes until the mask base cloth fully absorbs the full body;
5) pushing the processed semi-finished product into a freeze dryer, quickly cooling to-42 to-48 ℃, and keeping for 1.8 to 2.4 hours;
6) after the base cloth and the material body in the bottle are completely crystallized, vacuumizing and carrying out sublimation drying;
7) the sublimation drying time is 15-22 hours, and air is discharged out of the box after the drying is finished;
8) and quickly capping the freeze-dried product, sampling and inspecting, detecting the moisture content and microorganisms, and packaging the qualified product of the batch for sale.
6. The method for preparing a freeze-dried mask according to claim 5, wherein the freeze-dryer is rapidly cooled to-44 to-46 ℃ for 1.9 to 2.2 hours.
7. The method for preparing a lyophilized mask according to claim 6, wherein the lyophilizer rapidly cools to-45 ℃ for 2 hours.
8. The method for preparing a freeze-dried mask according to claim 5, wherein the sublimation drying time is 16.5 to 20 hours.
9. The method of preparing a freeze-dried mask according to claim 5, wherein the sublimation drying time is 18 hours.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115813796A (en) * | 2022-06-13 | 2023-03-21 | 广州科美生物科技有限公司 | Composite polypeptide freeze-dried eye mask and preparation method thereof |
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| EP0308238A1 (en) * | 1987-09-18 | 1989-03-22 | Ethicon, Inc. | Stable lyophilized formulations containing growth factors |
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| EP0308238A1 (en) * | 1987-09-18 | 1989-03-22 | Ethicon, Inc. | Stable lyophilized formulations containing growth factors |
| CN110448521A (en) * | 2019-08-30 | 2019-11-15 | 英科博雅集团有限公司 | Stem Cell Activity factor facial mask sticking dressing and preparation method for skin repair |
| CN112603845A (en) * | 2020-12-30 | 2021-04-06 | 宇肽生物(东莞)有限公司 | Combined product of polypeptide freeze-dried tablet and no-addition secondary-throwing solvent and preparation method thereof |
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