CN113813245B - Slow-release sleep-aiding snuff - Google Patents

Abstract

The invention discloses a nasal suction for slow release and sleep aid. The slow-release sleep-aid nasal suction of the present invention comprises sleep-aid slow-release pellets and a solid frame. The sleep-aiding slow-release pellets include 5-15% of compound essential oil microcapsule powder in mass percentage, 0.1-20% of binder, 10-40% of pill-making auxiliary materials, 0.01-8% of additives and the balance of water. Among them, the preparation method of sleep-aiding sustained-release pellets is: dissolving adhesives and additives in pure water, and using the obtained solution as a wetting agent; mixing the wetting agent with compound essential oil microcapsules and pelleting auxiliary materials evenly, and preparing Soft material; the soft material is prepared into pellets by a pill making machine, dried and sieved; the solid frame includes elastic belts, link belts, and microporous capsules, which are used to place sleep-promoting slow-release pellets and fixed in the nasal cavity. The slow-release sleep-aiding nasal suction of the present invention has excellent sleep-aiding effect, and the slow-release time is as long as more than 12 hours.

Description

A slow-release sleep aid nasal suction

technical field

The invention relates to a slow-release nasal suction for sleep aid, which belongs to the technical field of daily chemistry.

Background technique

With the acceleration of the pace of modern life and the aggravation of the pressure of life and work, there are more and more patients with insomnia, and insomnia has become a potential threat to human health. According to the epidemiological survey of foreign scholars, 10%-30% of the population suffers from insomnia. As a common disease in the world, insomnia has caused great troubles to people's daily life and work, and has become an urgent health problem in the current society.

According to statistics, about 20% of patients with chronic insomnia choose to use sedative and hypnotic drugs and antidepressants to solve the insomnia problem. Long-term use will lead to drug dependence, sleep apnea, sleep rhythm disorder, and allergic reactions. The toxicity can affect the nervous system. , digestive system, hematopoietic system and urinary system and many other side effects. Therefore, many researchers are aware of the importance of non-drug treatment of sleep disorders. There are a variety of non-drug treatments for insomnia. Aromatherapy is used to calm the mind and calm the mind. It has a long history of use to help sleep. With the advancement of modern technology, the application of aromatherapy has expanded various dosage forms such as essential oils and aromatherapy, and the use is safer and more portable.

Contents of the invention

The technical problem solved by the present invention is: how to avoid the side effects and uncertainty of the effect of drug intervention to help sleep, so as to develop a nasal suction product for calming the nerves and helping sleep for people with insomnia.

In order to solve the above-mentioned technical problems, the present invention provides a kind of sustained-release sleep-aid nasal suction, comprising sleep-aid sustained-release pellets and a solid frame, the sleep-aid slow-release pellets include compound essential oil microcapsule powder 5- 15%, binder 0.1-20%, pelleting auxiliary material 10-40%, additive 0.01-8% and the rest of water; the composition of the compound essential oil microcapsule powder includes compound essential oil, and the compound essential oil includes tuberose Jade essential oil, patchouli essential oil, goldenrod essential oil and orange leaf essential oil.

Preferably, the content of compound essential oil in the compound essential oil microcapsule powder is 0.5-5%; the mass ratio of tuberose essential oil, patchouli essential oil, goldenrod essential oil and orange leaf oil in the compound essential oil is 5- 10:1-4:1-4:0.5-3.

Preferably, the binder is a combination of one or more of hypromellose K4M, hypromellose K15M or hypromellose K100M; the pelletizing auxiliary material is microcrystalline A compound of one or more of cellulose, lactose, pregelatinized starch, corn starch, sodium carboxymethylcellulose or mannitol; the additives are agar, poloxamer 407, carbomer 974P One or more of NF, Carbomer 971P NF or polyethylene glycol 6000.

Preferably, the preparation method of the sleep-aiding sustained-release pellets comprises:

The adhesive and additives are dissolved in pure water, and the resulting solution is used as a wetting agent; the wetting agent is mixed with the compound essential oil microcapsule powder and pelletizing auxiliary materials evenly to prepare a soft material; the soft material is prepared by using a pellet machine The pellets can be dried and sieved; the concentration of the wetting agent is 0.05-0.1%.

Preferably, the preparation method of the compound essential oil microcapsule powder comprises: adding the compound essential oil, Tween 80 and Span 60 to the aqueous solution of sodium alginate, stirring evenly to obtain a turbid liquid, adding the chitosan acetic acid solution dropwise to The compound oil microcapsule emulsion is prepared by complex coacervation method in the above turbid liquid, which is freeze-dried to obtain the compound essential oil microcapsule powder.

Preferably, the mass ratio of the compound essential oil, Tween 80 and Span 60 is 5:15:2, and the mass concentration of sodium alginate in the aqueous solution of sodium alginate is 1-2%; the chitosan The mass concentration of chitosan in the sugar-acetic acid solution is 2-3%; the ratio of the compound essential oil, the aqueous solution of sodium alginate and the chitosan-acetic acid solution is 5g:2L:1L.

Preferably, the solid frame is composed of elastic belts, link belts and microporous capsules; the sleep-aiding sustained-release pellets are arranged in the microporous capsules with a sealed structure.

Preferably, the elastic belt is made of at least one material of metal or polymer material, and has a length of 2-5 mm; the link belt is made of at least one material of metal or polymer material into, the length is 3-6 mm.

Preferably, the microporous capsule is made of at least one material in metal or polymer material, the microporous capsule is spherical with a diameter of 3-5 mm, and the surface of the microporous capsule is close to the linking band One side is provided with evenly distributed micropores.

Preferably, the diameter of the micropore is set to 0.5 mm.

Compared with the prior art, the present invention has the following beneficial effects:

1. A slow-release sleep-aiding nasal suction of the present invention is directly placed in the nasal cavity and can act on the human body through normal breathing. The bioavailability of plant essential oils is high, and it has excellent sleep-aiding effect, convenient and comfortable to use, and easy to use. Portable and other advantages, suitable for people of all ages to use;

2. A slow-release sleep aid nasal suction of the present invention, which uses natural plant essential oil formula as the main raw material, is safe and efficient, avoids the side effects of sedative and hypnotic drugs, and has extremely high promotion and application value;

3. The preparation method of the slow-release sleep aid nasal suction of the present invention is simple, easy to operate, and low in cost.

Description of drawings

Fig. 1 is a structural schematic diagram of a slow-release sleep-aid nasal suction of the present invention.

detailed description

In order to make the present invention more comprehensible, preferred embodiments are described in detail below with accompanying drawings. The specifications of various raw materials or reagents used in the following examples and the information of the manufacturer are shown in Table 1

Table 1 Specifications and manufacturers of raw material reagents

raw material name Specification Manufacturer HPMC K4M Analytical pure Sinopharm Chemical Reagent Co., Ltd. Poloxamer 407 Analytical pure Sinopharm Chemical Reagent Co., Ltd. microcrystalline cellulose Analytical pure Sinopharm Chemical Reagent Co., Ltd. corn starch Analytical pure Sinopharm Chemical Reagent Co., Ltd. Mannitol Analytical pure Sinopharm Chemical Reagent Co., Ltd. Sodium carboxymethyl cellulose Analytical pure Sinopharm Chemical Reagent Co., Ltd. Span 60 Analytical pure Sinopharm Chemical Reagent Co., Ltd. Tween 80 Analytical pure Sinopharm Chemical Reagent Co., Ltd. sodium alginate Analytical pure Sinopharm Chemical Reagent Co., Ltd. Chitosan Analytical pure Sinopharm Chemical Reagent Co., Ltd. Tuberose Essential Oil France Robert Flavors & Fragrances Patchouli Essential Oil France Robert Flavors & Fragrances A goldenrod essential oil France Robert Flavors & Fragrances Orange Leaf Essential Oil France Robert Flavors & Fragrances

The model of instrument equipment used in the following examples and the information of manufacturer are as shown in table 2:

Table 2 Instrument model and manufacturer

Example 1

(1) Preparation of Compound Essential Oil Microcapsules

Mix tuberose, patchouli oil, goldenrod, and orange leaf oil according to the mass-to-volume ratio of 5:2:2:1, and add 5g of compound essential oil, 15g of Tween 80, and 2g of Span 60 to 2L 1% sodium alginate aqueous solution, after stirring evenly, add 1L of 1% chitosan-acetic acid aqueous solution dropwise to the above cloudy liquid, and prepare compound essential oil microcapsule emulsion by complex coacervation method, and then freeze-dry to obtain essential oil microcapsule powder . (The configuration of 1% sodium alginate aqueous solution: accurately weigh 2g of sodium alginate solid powder, add 100ml of distilled water, stir with a stirrer at room temperature for 1 to 2 hours, after dissolving, continue to add 100ml of distilled water, continue stirring, Uniform viscous solution); (preparation of 1% chitosan-acetic acid aqueous solution: accurately weigh 1g of chitosan and put it in a beaker, add 100ml of 1% acetic acid aqueous solution and stir under a magnetic stirrer, heat at 30°C until completely dissolved, set aside )

(2) Preparation of Sleep-Aiding Sustained Release Pellets

The proportioning ratio of each component of the preparation of sleep-aiding sustained-release pellets is shown in Table 3.

Table 3 The distribution ratio of each component of Zhumian Sustained Release Pellets

components effect Dosage Compound essential oil microcapsules Functional ingredients 60g HPMC K4M Adhesive 60g Poloxamer 407 thickener 4g microcrystalline cellulose Pilling accessories 136g corn starch Pilling accessories 140g Mannitol Pilling accessories 80g Sodium carboxymethyl cellulose Pilling accessories 120g Deionized water solvent 1330g

Dissolve the binder (HPMC K4M) and additive (poloxamer 407) in pure water, and the resulting solution is used as a wetting agent; then the wetting agent is mixed with essential oil microcapsules and pelleting auxiliary materials to prepare a soft material ; The soft material is prepared into pellets by using a pellet machine, dried and sieved to obtain the product.

(3) Preparation of slow-release nasal suction for sleep aid

The prepared sleep-aiding sustained-release pellets are placed in the microporous capsules of the solid frame, and the nasal suction is sealed and packaged. The specific structure of the slow-release sleep-aid nasal suction is shown in Figure 1, which includes sleep-aid slow-release pellets and a solid frame; the solid frame is composed of elastic bands, link belts and microporous capsules; the sleep-aid slow-release pellets are located In the microporous capsule of the structure.

Among them, the elastic belt is made of at least one material of metal or polymer material, and the length is 2-5 mm; the link belt is made of at least one material of metal or polymer material, and the length is 3-6 mm. mm; the microporous capsule is made of at least one material in metal or polymer material, the microporous capsule is spherical with a diameter of 3-5 mm, and the surface of the microporous capsule is provided with evenly distributed microporous hole; the diameter of the microhole is set to 0.5 mm.

Comparative Example 1

(1) Preparation of microcapsule powder

Add 15g of Tween 80 and 2g of Span 60 into 2L of 1% sodium alginate aqueous solution, stir evenly, then drop 1L of 1% chitosan-acetic acid aqueous solution into the above cloudy solution, and prepare microcapsules by complex coacervation method emulsion, and then freeze-dried to obtain microcapsule powder.

(2) Preparation of Sleep-Aiding Sustained Release Pellets

The proportioning ratio of each component of the preparation of sleep-aiding sustained-release pellets is shown in Table 4.

Table 4 The distribution ratio of each component of Zhumian Sustained Release Pellets

components effect Dosage microcapsule powder Functional ingredients 60g HPMC K4M Adhesive 60g Poloxamer 407 thickener 4g microcrystalline cellulose Pilling accessories 136g corn starch Pilling accessories 140g Mannitol Pilling accessories 80g Sodium carboxymethyl cellulose Pilling accessories 120g Deionized water solvent 1330g

The binder (HPMC K4M) and the additive (poloxamer 407) are dissolved in pure water, and the resulting solution is used as a wetting agent; then the wetting agent is mixed with the microcapsule empty shell and pelletizing auxiliary materials to prepare a soft material; the soft material is prepared into pellets by using a pelletizing machine, dried and sieved to obtain final product.

(3) Preparation of slow-release nasal suction for sleep aid

The prepared sleep-aiding sustained-release pellets are placed in the microporous capsules of the solid frame, and the nasal suction is sealed and packaged.

Example 2

(1) Preparation of compound essential oil microcapsule powder

Mix tuberose, patchouli oil, goldenrod, and orange leaf oil according to the mass-to-volume ratio of 5:3.5:1:0.5. Take 5g of the mixed compound essential oil, 15g of Tween 80, and 2g of Span 60 and add it to 2L 1% sodium alginate aqueous solution, after stirring evenly, add 1L of 1% chitosan-acetic acid aqueous solution dropwise to the above cloudy liquid, and prepare compound essential oil microcapsule emulsion by complex coacervation method, and then freeze-dry to obtain essential oil microcapsule powder .

(2) Preparation of Sleep-Aiding Sustained Release Pellets

The proportioning ratio of each component of the preparation of sleep-aiding sustained-release pellets is shown in Table 5.

Table 5 The distribution ratio of each component of Zhumian Sustained Release Pellets

components effect Dosage Compound essential oil microcapsules Functional ingredients 60g HPMC K4M Adhesive 60g Poloxamer 407 thickener 4g microcrystalline cellulose Pilling accessories 136g corn starch Pilling accessories 140g Mannitol Pilling accessories 80g Sodium carboxymethyl cellulose Pilling accessories 120g Deionized water solvent 1330g

The binder (HPMC K4M) and the additive (poloxamer 407) are dissolved in pure water, and the resulting solution is used as a wetting agent; then the wetting agent is mixed with the microcapsule empty shell and pelletizing auxiliary materials to prepare a soft material; the soft material is prepared into pellets by using a pelletizing machine, dried and sieved to obtain final product.

(3) Preparation of slow-release nasal suction for sleep aid

The prepared sleep-aiding sustained-release pellets are placed in the microporous capsules of the solid frame, and the nasal suction is sealed and packaged.

Example 3

(1) Preparation of compound essential oil microcapsule powder

Mix tuberose, patchouli oil, goldenrod, and orange leaf oil according to the mass-to-volume ratio of 3:3:3:1, and add 5g of compound essential oil, 15g of Tween 80, and 2g of Span 60 to 2L 1% sodium alginate aqueous solution, after stirring evenly, add 1L of 1% chitosan-acetic acid aqueous solution dropwise to the above cloudy liquid, and prepare compound essential oil microcapsule emulsion by complex coacervation method, and then freeze-dry to obtain essential oil microcapsule powder .

(2) Preparation of Sleep-Aiding Sustained Release Pellets

The proportioning ratio of each component of the preparation of sleep-aiding sustained-release pellets is shown in Table 6.

Table 6 The distribution ratio table of each component of Zhumian Sustained Release Pellets

components effect Dosage Compound essential oil microcapsules Functional ingredients 60g HPMC K4M Adhesive 60g Poloxamer 407 thickener 4g microcrystalline cellulose Pilling accessories 136g corn starch Pilling accessories 140g Mannitol Pilling accessories 80g Sodium carboxymethyl cellulose Pilling accessories 120g Deionized water solvent 1330g

The binder (HPMC K4M) and the additive (poloxamer 407) are dissolved in pure water, and the resulting solution is used as a wetting agent; then the wetting agent is mixed with the microcapsule empty shell and pelletizing auxiliary materials to prepare a soft material; the soft material is prepared into pellets by using a pelletizing machine, dried and sieved to obtain final product.

(3) Preparation of slow-release nasal suction for sleep aid

The prepared sleep-aiding sustained-release pellets are placed in the microporous capsules of the solid frame, and the nasal suction is sealed and packaged.

Example 4

(1) Preparation of compound essential oil microcapsule powder

Mix tuberose, patchouli oil, goldenrod, and orange leaf oil according to the mass-to-volume ratio of 2.5:2.5:2.5:2.5. Take 5g of the mixed compound essential oil, 15g of Tween 80, and 2g of Span 60 and add it to 2L 1% sodium alginate aqueous solution, after stirring evenly, add 1L of 1% chitosan-acetic acid aqueous solution dropwise to the above cloudy liquid, and prepare compound essential oil microcapsule emulsion by complex coacervation method, and then freeze-dry to obtain essential oil microcapsule powder .

(2) Preparation of Sleep-Aiding Sustained Release Pellets

The proportioning ratio of each component for the preparation of sleep-aiding sustained-release pellets is shown in Table 7.

Table 7 The distribution ratio of each component of Zhumian Sustained Release Pellets

components effect Dosage Compound essential oil microcapsules Functional ingredients 60g HPMC K4M Adhesive 60g Poloxamer 407 thickener 4g microcrystalline cellulose Pilling accessories 136g corn starch Pilling accessories 140g Mannitol Pilling accessories 80g Sodium carboxymethyl cellulose Pilling accessories 120g Deionized water solvent 1330g

The binder (HPMC K4M) and the additive (poloxamer 407) are dissolved in pure water, and the resulting solution is used as a wetting agent; then the wetting agent is mixed with the microcapsule empty shell and pelletizing auxiliary materials to prepare a soft material; the soft material is prepared into pellets by using a pelletizing machine, dried and sieved to obtain final product.

(3) Preparation of slow-release nasal suction for sleep aid

The prepared sleep-aiding sustained-release pellets are placed in the microporous capsules of the solid frame, and the nasal suction is sealed and packaged.

Example 5

Efficacy evaluation of slow-release nasal suction for sleep aid:

The sleep quality of the subjects was subjectively evaluated by the Pittsburgh Sleep Index (PSQI). PSQI was compiled by Dr. Buysse and others from the University of Pittsburgh in 1989. It is an authoritative and commonly used sleep test evaluation scale in the world. When the score of this table drops ≥ 3 points, it is judged that the subjective sleep quality has improved.

According to the Pittsburgh Sleep Index Scale, select the poor sleep quality group with scores between 11≤X≤15 points (this group has not used central nervous system drugs in the past week and has no other diseases in the body), and finally screened out 30 patients in each group. tester. The subjects wore the sleep suction in their nostrils every night when they went to bed, used it for 7 consecutive days, and made a subjective evaluation according to the Pittsburgh Sleep Index Scale. The evaluation results are shown in Table 8.

Table 8 The decline of PSQI scores before and after 7 days of using sleep snorting

From the experimental results of Example 1 and Comparative Example 1 in Table 8, it can be seen that the sleep-promoting nasal suction containing essential oils has a good sleep-promoting effect, and the nasal suction without essential oil has no sleep-promoting effect. From the experimental results of Example 1 and Comparative Example 1, Example 2, Example 3, and Example 4 in Table 8, it can be seen that the compounding ratio of essential oils will also have a greater impact on the sleep-promoting effect, and the best use is recommended The ratio is 5:2:2:1.

The foregoing is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any form and in essence. Several improvements and supplements are made, and these improvements and supplements should also be regarded as the protection scope of the present invention.

Claims (8)

1. The slow-release sleep-aiding snuff is characterized by comprising sleep-aiding slow-release pellets and a solid frame, wherein the sleep-aiding slow-release pellets are prepared from 5-15 mass percent of compound essential oil microcapsule powder, 0.1-20 mass percent of adhesive, 10-40 mass percent of pill-making auxiliary material, 0.01-8 mass percent of additive and the balance of water; the compound essential oil microcapsule powder comprises compound essential oil, wherein the compound essential oil consists of tuberose essential oil, patchouli essential oil, solidago virgaurea essential oil and tangerine leaf essential oil; the mass ratio of the tuberose essential oil to the patchouli essential oil to the solidago virgaurea essential oil to the tangerine leaf essential oil is 5:2:2:1;

the adhesive is hydroxypropyl methylcellulose K4M; the auxiliary materials for preparing the pills are the compound of microcrystalline cellulose, corn starch, sodium carboxymethylcellulose and mannitol; the additive is poloxamer 407;

the preparation method of the compound essential oil microcapsule powder comprises the following steps: adding compound essential oil, tween 80 and span 60 into sodium alginate water solution, stirring to obtain turbid solution, adding chitosan acetic acid solution dropwise into the turbid solution, preparing compound oil microcapsule emulsion by complex coacervation method, and freeze drying to obtain compound essential oil microcapsule powder.

2. The slow-release sleep-aiding snuff according to claim 1, wherein the compound essential oil microcapsule powder contains 0.5-5% of compound essential oil.

3. The sustained-release sleep-aiding snuff according to any one of claims 1-2, wherein the preparation method of the sleep-aiding sustained-release pellet comprises the following steps:

dissolving an adhesive and an additive in pure water, and taking the obtained solution as a wetting agent; uniformly mixing the wetting agent, the compound essential oil microcapsule powder and the pelleting auxiliary materials to prepare a soft material; preparing the soft material into micro-pills by a pill making machine, drying and screening; the concentration of the wetting agent is 0.05-0.1%.

4. The sustained-release sleep-aiding snuff as claimed in claim 3, wherein the mass ratio of the compound essential oil to the tween 80 to the span 60 is 5; the mass concentration of chitosan in the chitosan acetic acid solution is 2-3%; the ratio of the compound essential oil to the sodium alginate aqueous solution to the chitosan acetic acid solution is 5 g.

5. The slow release sleep-aid snuff according to claim 1, wherein the solid frame is comprised of an elastic band, a linking band, and a microporous pouch; the sleep-aiding sustained-release pellet is arranged in a microporous capsule with a sealing structure.

6. The slow-release sleep-aiding snuff according to claim 5, wherein the elastic band is made of at least one of metal or polymer materials and has a length of 2-5 mm; the chain belt is made of at least one of metal or high polymer materials, and the length of the chain belt is 3-6 mm.

7. The slow-release sleep-assisting snuff as claimed in claim 6, wherein the micro-porous capsule is made of at least one of metal or polymer materials, the micro-porous capsule is spherical with a diameter of 3-5 mm, and the surface of the micro-porous capsule, which is close to the side of the linking belt, is provided with uniformly distributed micro-pores.

8. The sustained release sleep-aiding snuff of claim 7, wherein the pores are set to 0.5 mm in diameter.

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