Disclosure of Invention
The technical problem to be solved by the invention is as follows: the human brain dynamic body simulating device and the near infrared optical instrument accuracy calibrating method are provided for calibrating the accuracy of the near infrared optical detection device.
The technical scheme adopted by the invention for solving the technical problems is as follows: the human brain dynamic body-simulating device comprises a brain tissue physical environment simulation module, a chromophore simulation module, a motion control module and a human-computer interaction module; the brain tissue physical environment simulation module is provided with an instrument interface for connecting an instrument to be calibrated, and the inside of the brain tissue physical environment simulation module is filled with a fat emulsion Intralipid solution with the concentration of 1% for simulating the human brain tissue physical environment; the chromophore simulation module is assembled in the brain tissue physical environment simulation module and simulates the concentration change of the chromophore in the optical mode through the depth change of color, and is used for dynamically simulating the biological performances including absorption and scattering of light radiation generated by the chromophore in each region of the human brain when the brain moves; the signal output end of the man-machine interaction module is connected with the signal input end of the motion control module and used for sending a control instruction to the motion control module according to a pre-input brain function activity mode; the signal input end of the man-machine interaction module is connected with the signal output end of the instrument to be calibrated and is used for receiving, processing and displaying the test data and the calibration result of the instrument to be calibrated; the motion output end of the motion control module is connected with the chromophore simulation module and is used for driving the chromophore simulation module to simulate the motion of the brain activity; the chromophore emulation module comprises at least one movable color bar having a difference in color value; the color bar is a long rod made of a light-transmitting material, a plurality of annular color bands are sequentially distributed on the surface of the long rod from top to bottom, and the colors of the color bands are darkened or lightened by adjusting RGB values from top to bottom.
According to the scheme, the color bands of the same color bar adopt linearly-changed color spectrums, the color change degrees of the color bands are consistent, and the widths of the color bands are consistent; the color bars are classified according to the precision, and comprise high-precision color bars and low-precision color bars; the width of the color ribbon of the high-precision color bar is less than 10 mm; the width of the color ribbon of the low-precision color bar is more than or equal to 10mm and less than 30 mm; the higher the size and the detection precision of a sensor of the instrument to be calibrated are, the smaller the width of a single color band is, and the larger the measurement range of the instrument to be calibrated is, the larger the span of the color spectrum on the same color bar is; selecting the color and the shade of the color bar according to the target observed quantity of the instrument to be calibrated; if the target observed quantity is the blood oxygen saturation degree, selecting a red color bar; if the simulation is that the surface layer of the human brain has less activity and the deep layer has more activity, selecting a darkened color bar; if the simulation is that the surface layer of the human brain has more activity and the deep layer has less activity, selecting a color bar which becomes lighter; the color bar is in a solid shape obtained by normal stretching of a plane closed graph, and comprises a cylinder, a cuboid and a triangular prism; the surface of the color band is roughened by adopting a frosting process or smearing matte paint, and the surface is used for enhancing the scattering ability of the color band so as to simulate the absorption and reflection of chromophore to light; light transmissive materials include, but are not limited to, PMMA, PE, FEP.
According to the scheme, the brain tissue physical environment simulation module comprises a top box, wherein the top box is a closed container made of shading materials; the light-shielding material has light transmittance lower than 1% and is not easy to react with Intralipid solution, including but not limited to black ABS, PPO and POM; the surface of the top box is sprayed with black paint for absorbing light penetrating through the shading material; the top surface of the top box is provided with an instrument interface which is made of a light-transmitting material comprising PMMA; a hollow channel vertical to the top surface of the top box is arranged in the top box and is used for the color bar to reciprocate; the cross section shape of the hollow channel is matched with that of the color bar; the upper and lower surfaces of the top case have a usable area not smaller than the area of the human brain, and are set to 390 × 390mm
2(ii) a The cross section area of the single hollow channel is smaller than
The height of the top box is more than 30mm, and the length of the color rod is longer than the height of the top box by a certain distance, so that the preset length of the color rod is ensured to extend into the top box; the hollow channels are parallel to each other; the hollow channels in each row are closely arranged, and the hollow channels in two adjacent rows are closely arranged in a staggered manner.
According to the scheme, the man-machine interaction module comprises a display unit, a data processing unit and a switch; the data processing unit comprises a communication module and a processor; the communication module is used for transmitting data with an upper computer or a remote platform; the processor is used for comparing the test data of the instrument to be calibrated with the pre-input brain function activity mode to obtain the accuracy of the instrument to be tested, or comparing the detection data of the sensor of the instrument to be calibrated with the pre-input brain function activity mode to obtain the calibration data of the sensor; the display unit is used for inputting instructions, consulting commands, displaying data and results; the switch is used for starting and stopping the operation of the human brain dynamic simulator.
According to the scheme, the device further comprises a mounting frame; the mounting frame comprises a base and a fixing bracket; the four corners of the base are provided with second supporting columns, the bottom surface of the fixing support is provided with second positioning grooves, the second supporting columns are assembled in the second positioning grooves, and the base and the fixing support are positioned through the second supporting columns and the second positioning grooves and are detachably connected; the top of the fixed support is provided with a first support column, the bottom of the top box is provided with a first positioning groove, the first support column is assembled in the first positioning groove, and the fixed support and the top box are positioned and detachably connected through a second support column and a second positioning groove; the man-machine interaction module is arranged inside the base; the top surface of base is equipped with the motor recess.
Further, the motion control module comprises a motion unit and a control unit; the motion unit comprises a lifting mechanism; the lifting mechanism is used for driving the color bar to do up-and-down reciprocating motion and comprises a bearing bracket, a screw rod, a guide rail, a sliding block and a motor; the guide rail is fixed between the bearing brackets; the screw rod is parallel to the guide rail, takes the central shaft as a rotating shaft and is connected between the bearing brackets through a bearing; the motor is assembled in the motor groove, and the bearing support is detachably connected and fixed on the top surface of the base and the bottom surface of the fixed support respectively; the sliding block is provided with two holes which are respectively sleeved on the screw rod and the guide rail, the hole sleeved with the screw rod is a threaded hole matched with the screw rod, and the hole sleeved with the guide rail is a through hole; the sliding block is also provided with an assembly hole A, and the assembly hole A is used for fixing the bottom of the color bar; the motor is arranged at the bottom of the bearing connected with the screw rod and used for driving the screw rod to rotate so as to enable the sliding block to do vertical linear motion; the motor is a servo motor; the control end of the control unit is connected with the controlled end of the motor and used for converting the received data into instructions and sending the instructions to the motor.
Furthermore, in order to simulate the human brain environment with less superficial blood oxygen activity and more deep blood oxygen activity including oxyhemoglobin and deoxyhemoglobin chromophore, the diameter of the color setting stick is 5mm, and the length is 120 mm; the height of the top box is 100 mm; the single color band width of the color setting bar is 5mm, and the total width of the color band is 30 mm; the color bar a is deeper from top to bottom, the color value range of the color bar a is sequentially RGB (255, 120, 120) -RGB (255, 100, 100), RGB (255, 100, 100) -RGB (255, 80, 80), RGB (255, 80, 80) -RGB (255, 60, 60), RGB (255, 60, 60) -RGB (255, 40, 40), RGB (255, 40, 40) -RGB (255, 20, 20), RGB (255, 20, 20) -RGB (255, 0, 0), and a linearly-changed color value is designed in each color bar and used for simulating an oxygenated hemoglobin chromophore; the color bar b is deeper from top to bottom, the color bar 5 sequentially has color values ranging from RGB (255, 120, 255) -RGB (255, 100, 255), RGB (255, 100, 255) -RGB (255, 80, 255), RGB (255, 80, 255) -RGB (255, 60, 255), RGB (255, 60, 255) -RGB (255, 40, 255), RGB (255, 40, 255) -RGB (255, 20, 255), RGB (255, 20, 255) -RGB (255, 0, 255), and the color bar 5 is designed with linearly changing color values inside each color bar to simulate a deoxyhemoglobin chromophore.
The precision calibration method of the near-infrared optical instrument comprises the following steps:
s1: the human brain dynamic body simulating device comprises a brain tissue physical environment simulation module, a chromophore simulation module, a motion control module and a human-computer interaction module; the brain tissue physical environment simulation module is provided with an instrument interface, and the inside of the brain tissue physical environment simulation module is filled with a 1% fat emulsion Intralipid solution; the chromophore simulation module is assembled in the brain tissue physical environment simulation module; the signal output end of the man-machine interaction module is connected with the signal input end of the motion control module; the signal input end of the man-machine interaction module is connected with the signal output end of the instrument to be calibrated; the motion output end of the motion control module is connected with the chromophore simulation module; the chromophore emulation module comprises at least one movable color bar having a difference in color value; the color bar is a long rod made of a light-transmitting material, and a plurality of annular color bands are sequentially distributed on the surface of the long rod from the top to the bottom; selecting a color bar to be installed according to the detection purpose and the target observed quantity;
s2: connecting an instrument to be calibrated to an instrument interface; inputting the corresponding brain function activity mode to a human-computer interaction module;
s3: the man-machine interaction module processes the data template and sends the data template to the motion control module;
s4: the motion control module receives data, converts the data into instructions and executes the instructions, and drives the color bars to reciprocate in the brain tissue physical environment simulation module to form different color bar combinations so as to complete the simulation of the chromophore;
s5: the instrument to be calibrated acquires data and sends the data to the man-machine interaction module;
s6: and the human-computer interaction module receives the acquired data and compares the acquired data with the brain function activity mode in the step S2 to obtain an accuracy report of the instrument to be calibrated.
Further, in step S1, the specific steps include:
s11: selecting a color bar according to the detection purpose and the target observed quantity;
s12: installing the color bar on a lifting mechanism of a motion control module to form a complete motion unit;
s13: sequentially installing the moving units between the base and the fixed support to enable the color rods to penetrate through the fixed support; a fixed base and a fixed bracket;
s14: inserting the color bar into the top box from the bottom, and fixing the top box and the fixing bracket;
s15: and the motion control module and the human-computer interaction module are connected.
Further, steps S5 and S6 are replaced with the following steps:
a sensor of an instrument to be calibrated acquires data and sends the data to a man-machine interaction module;
and the human-computer interaction module receives the acquired data and compares the acquired data with the brain function activity mode in the step S2 to obtain a reliability report.
The invention has the beneficial effects that:
1. according to the human brain dynamic body-simulating device and the near-infrared optical instrument accuracy calibration method, the function of calibrating the accuracy of the near-infrared optical detection device is realized by simulating the test environment of the near-infrared optical instrument and accurately quantifying the characteristics, the problem that the near-infrared optical detection industry lacks the inspection standard is solved, the effective inspection standard is provided for the near-infrared optical detection, and the foundation is laid for the development of the near-infrared spectrum standardization industry.
2. Compared with animal experiments, the invention has the advantages of standardized production, repeated use, controllable parameters and stable and controllable working environment.
3. The invention reduces the production cost and the detection cost and the medical cost.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.
Referring to fig. 1, an embodiment of the present invention includes a device body, a brain tissue physical environment simulation module, a chromophore simulation module, a human-computer interaction module, and a motion and control module.
The device main part includes base 4 and fixed bolster 2, and base 4 is provided with the recess of installation motion unit, and the motion unit passes through the screw fixation at base 4, and base 4 is provided with the support column, and fixed bolster 2 sets up the recess of assembly pillar, and base 4 and fixed bolster 2 pass through for screwed connection after pillar and the recess location, form the whole framework of device after the pillar in 4 four corners of base and the bottom recess location assembly of fixed bolster 2. The fixed support 2 is provided with a supporting column, the brain tissue physical environment simulation module is provided with a groove for assembling the supporting column, and the fixed support 2 is connected and fastened with the brain tissue physical environment simulation module through screws.
The brain tissue physical environment simulation module comprises a top box 1, and the top box 1 is installed on the upper portion of the fixing frame through screws. As shown in fig. 2, the top box 1 is a closed container made of a light-shielding material, and the light-shielding material has properties of high hardness, strong corrosion resistance, light transmittance lower than 1%, good wear resistance, stable chemical properties, and difficulty in reacting with an intralid solution, and includes but is not limited to materials such as black ABS, PPO, and POM; in order to ensure that the light transmittance is lower than 1%, black paint can be sprayed on the outer surface of the container to absorb light penetrating through the material. The upper cover of the top box 1 is provided with an external interface which can be connected with a probe and a light source of related detection equipment, the material of the interface is favorable for light rays such as near infrared light and the like to penetrate, and the polymethyl methacrylate PMMA material is selected.
As shown in fig. 3, a hollow cylindrical passage is provided inside the top case 1 as a passage through which the
color bar 5 reciprocates. The inside of the top box 1 was filled with a 1% fat emulsion Intralipid solution to simulate the physical environment of human brain tissue. The maximum value of the head circumference is 680mm, so that the area of the human brain is obtained and is specifically set to 390 × 390mm as the using area of the upper surface and the lower surface of the top box 1
2. The optimal distance of the source probe for the reference near infrared detection is 30mm, so that the single occupied area of the cylindrical hollow channel is set to be

At present, the deepest distance of the brain of a human body is about 30mm, the detection depth is improved for ensuring that the activity of the human body can be completely detected and the technology is improved, the height of the top box 1 is higher than 30mm, and the height of the top box 1 is determined to be 100 mm. The shape of the cylindrical hollow channel of the brain tissue physical environment simulation module is not limited to a cylinder, and closed shapes such as a diamond shape, a triangle shape, a hexagon shape and the like are also suitable. The total number of the cylindrical hollow channels is 618, the first row is provided with 13 cylindrical hollow channels, the second row is provided with 12 cylindrical hollow channels which are arranged backwards from the middle position of the two cylindrical hollow channels in the front of the first row, the cylindrical hollow channels in each row are arranged in a zero-gap mode, and the cylindrical hollow channels in two adjacent rows are arranged in a zero-gap modeThe two arrangement modes are staggered and arrayed, and 13 rows are formed in total. The staggered arrangement between two adjacent rows is to establish more detection channels, and compared with the condition that each row is arranged consistently, the detection channels of the
same color bar 5 are at least two more channels arranged by 15mm in a staggered manner. The bottom of the external interface of the brain tissue physical environment simulation module and the cylindrical hollow channel are made of transparent materials. The material should have the properties of high light transmittance, low haze, good weather resistance, and permeability to near infrared rays, including but not limited to PE, FEP, PMMA, and the like.
The chromophore simulation module comprises at least one adjustable color bar 5 with color value difference and different color combinations, and is used for simulating the biological performance of absorption and scattering of light radiation when chromophores in various regions of a human brain perform brain activities, so as to realize dynamic simulation of the brain activities. The color bar 5 is a long rod made of transparent material, including but not limited to PMMA, PE, FEP, etc. The surface of the long rod is distributed with an annular color band from the top to the bottom, the color of the color band becomes dark or light from top to bottom, and the color depth is adjusted by adjusting the RGB value. The same long rod has only one color, the color bands have the same width, the color can be changed from one color to the other color in a deepening or lightening mode, and the color change degrees of the color bands are the same. In this embodiment, red is selected, the width of the color band is 5mm, and the color is lighter from top to bottom.
The color bars 5 are also classified according to the precision, the color bands of the high-precision color bars are narrow, and the width is generally more than or equal to 5mm and less than 10 mm; the color band width of the low-precision color bar is generally more than or equal to 10mm and less than 30 mm. The division is based on the precision of the sensor, the precision of the sensor is high, the precision is high, and the color and the shade change in the narrow color band can be clearly distinguished; on the other hand, if the sensor accuracy is low, the accuracy is low, and the color and shade variation of the narrow color band are difficult to be discriminated, and only the color and shade variation of the wide color band can be roughly discriminated. According to the existing literature, the near infrared spectrum detects that the depth of the human brain reaches 3cm below the cerebral cortex at most, so the width of a color band does not exceed 3cm, the detection precision of the current near infrared sensor is known, the width of the color band cannot be lower than 5mm, and the single width and the total width of a color ring can be continuously adjusted according to the upgrade of the near infrared sensor and the improvement of the detection precision; the single width of the color band can be continuously reduced along with the size of the near infrared sensor and the upgrading and the renovation of the detection precision, and the total width of the color band can be continuously widened along with the increase of the detection depth of the near infrared spectrum detection technology. The shape of the color bar 5 includes, but is not limited to, a cylinder, a rectangular parallelepiped, a triangular prism, and the like, which are solid shapes obtained by stretching a planar closed figure.
The chromophore simulation module simulates the concentration change of the chromophore in the optical mode through the depth of the color; the capability of the color bar 5 for absorbing and scattering light is changed by changing the material or the processing technology of the color band; such as roughening the ribbon surface by a frosting process or applying a matte finish to increase the diffuse reflection of light and thus enhance the scattering ability of the ribbon. The color of the color bar is selected according to the target observed quantity required by detection, and if the observed quantity is the blood oxygen saturation, the red color bar 5 is preferentially selected to simulate red blood cells. Meanwhile, the color bar 5 with the color being darker or lighter is selected according to the detection purpose, for example, if the simulated brain blood oxygen activity is less on the surface layer and frequent in the deep layer, the color bar 5 with the color being darker is selected; if the simulation shows that the surface layer of the brain blood oxygen activity of the human is more active and the deep layer is not frequent, the color bar 5 which becomes lighter is selected.
As shown in FIG. 4, a long rod made of light-transmitting material polymethyl methacrylate PMMA is selected, the diameter is 5mm, and the total length is 120 mm. The 20mm length above the height of the top box 1 is to ensure that a 100mm length will be able to fully enter the top box 1 in the event of error or structural limitations. The environment simulated by this example is less superficial blood oxygenation activity and more deep blood oxygenation activity, including the oxyhemoglobin and deoxyhemoglobin chromophore. Therefore, color values of color bands of RGB (255, 120, 120) -RGB (255, 100, 100), RGB (255, 100, 100) -RGB (255, 80, 80), RGB (255, 80, 80) -RGB (255, 60, 60), RGB (255, 60, 60) -RGB (255, 40, 40), RGB (255, 40, 40) -RGB (255, 20, 20), RGB (255, 20, 20) -RGB (255, 0, 0) are sequentially selected from the top to the bottom in a simulated oxyhemoglobin mode, the color bars 5 with linearly changing color values are designed in the color bands, each color band is 5mm wide, the total width of the color bands is 30mm, and the color bars 5 are called color bars a. The color of the color bar darkens from top to bottom, simulating the oxygenated hemoglobin chromophore. The simulated deoxyhemoglobin adopts color bars 5 with color values of RGB (255, 120, 255) -RGB (255, 100, 255), RGB (255, 100, 255) -RGB (255, 80, 255), RGB (255, 80, 255) -RGB (255, 60, 255), RGB (255, 60, 255) -RGB (255, 40, 255), RGB (255, 40, 255) -RGB (255, 20, 255), RGB (255, 20, 255) and RGB (255, 20, 255) -RGB (255, 0, 255) in sequence from top to bottom, the color bars 5 with linearly changing color values are designed in each color bar, each color bar is 5mm wide, the total width of the color bar is 30mm, and the color bar 5 is called a color bar b. The color of the color bar darkens from top to bottom, mimicking the deoxyhemoglobin chromophore.
The man-machine interaction module comprises a display unit, a CPU data analysis and processing unit and a device body switch, wherein the CPU data analysis and processing unit comprises a data analysis and transmission chip and a terminal CPU which are positioned in the base 4, and the display unit comprises a display screen of the base 4 and a terminal display screen. The human-computer interaction module inputs the brain function activity mode through the CPU data analysis and processing unit. The CPU data analysis and processing unit transmits the processed data to the motion and control module. The detection device collects related data such as blood oxygen and the like and inputs the data into the CPU data analysis and processing unit, and the CPU data analysis and processing unit compares the detection data with the movable data template to obtain the accuracy of the measured instrument. The detection data of a sensor at a certain position detected by the detected instrument can also be compared with the real-time data through the CPU data analysis and processing unit.
The display unit comprises a display screen on the device base 4 and a display screen of an upper computer, and can input instructions and look up data.
The motion and control module comprises a motion unit and a control unit; the control unit comprises an integrated chip which is positioned at the lower end of the motor and is placed in the base 4, and the control unit forms a command with the received data and then is executed by the motion unit; the moving unit is positioned and installed with the base 4 and the fixed bracket 2 through screws, and comprises a lifting mechanism 3 and an actuating element color bar 5; the lifting mechanism 3 comprises a power source motor and a lifting component, the whole lifting mechanism 3 is based on the principle of a screw rod guide rail sliding block, the motor drives the screw rod 7 to rotate and convert the rotation into the linear motion of the sliding block 9, and the guide rail 8 plays a role in positioning and guiding. As shown in fig. 5, the lifting mechanism 3 includes a bearing bracket 6, a screw rod 7, a guide rail 8, a slider 9, and a stepping motor 10; in order to ensure that the stroke is controllable and convenient to adjust, a servo motor is generally selected as the motor; the lifting component comprises but is not limited to a sliding screw rod, a belt transmission component, a hydraulic transmission component and other transmission components, and a reciprocating motion mechanism such as a connecting rod mechanism, a driving cylinder driving column, a hydraulic push rod and the like; in the embodiment, the lifting mechanism 3 is formed by a servo motor and a sliding screw rod. As shown in fig. 6, the position a, i.e. the color bar fixing position, is a complete moving unit formed by installing the color bar 5 on the position a of the slide block 9 of the lifting mechanism 3.
The working principle of the device is as follows: brain function activity data is input in a CPU data analysis and processing unit through a man-machine interaction module in advance, and the CPU data analysis and processing unit transmits the processed data to a motion and control module. The motion and control module comprises a motion unit and a control unit respectively, the control unit forms a command with the received data and then is executed by the motion unit, so that the color bar 5 which is a main execution part in the motion unit reciprocates, and different color bars 5 are combined to form the chromophore module; then, the near infrared and other related detection devices are connected through an external interface designed by the device, and the detection devices can judge the accuracy of the instrument to be detected by acquiring the data such as the blood oxygen related to the dynamic simulator and comparing the data with a brain function activity data standard template which is input in a CPU data analysis and processing unit in advance. Meanwhile, the detection data of a certain sensor detected by the detected instrument can also be compared in real time through the device.
Referring to fig. 7, the detection method of the present invention includes the following steps:
s1: installing the device, and connecting the near-infrared detection equipment to be detected to an external interface of the device; selecting a color bar 5 and brain function activity data according to the detection purpose and the target observed quantity;
s11: mounting the selected color bar 5 on the lifting mechanism 3 to form a complete motion unit;
s12: the moving units are sequentially installed on the base 4, then the fixed support 2 is installed, and finally the top box 1 is installed.
S2: inputting a brain function activity mode to a CPU data analysis and processing unit of the human-computer interaction module, processing data by the CPU data analysis and processing unit and transmitting the data to the motion and control module;
s3: the control unit of the motion and control module receives the data, converts the data into instructions and then sends the instructions to the motion unit; the moving unit executes the instruction, controls the lifting mechanism 3 to drive the color bar 5 to reciprocate to form different color bar combinations, and completes the simulation of the chromophore;
s4: the access equipment acquires data including blood oxygen of brain activity simulated by the dynamic body simulator, inputs the data into the CPU data analysis and processing unit, and compares the data with a brain function activity mode input in advance to obtain an accuracy report of the access equipment; the sensor data of the access equipment is also compared with the data in real time through the device to obtain a reliability report.
The above embodiments are only used for illustrating the design idea and features of the present invention, and the purpose of the present invention is to enable those skilled in the art to understand the content of the present invention and implement the present invention accordingly, and the protection scope of the present invention is not limited to the above embodiments. Therefore, all equivalent changes and modifications made in accordance with the principles and concepts disclosed herein are intended to be included within the scope of the present invention.