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CN113777058A - Human brain dynamic phantom device and accuracy calibration method of near-infrared optical instrument - Google Patents

Human brain dynamic phantom device and accuracy calibration method of near-infrared optical instrument Download PDF

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CN113777058A
CN113777058A CN202111053540.2A CN202111053540A CN113777058A CN 113777058 A CN113777058 A CN 113777058A CN 202111053540 A CN202111053540 A CN 202111053540A CN 113777058 A CN113777058 A CN 113777058A
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CN113777058B (en
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李睿
吴启明
吴艳兵
庞媛
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Wuhan Yiruide Medical Equipment Co Ltd
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Wuhan Aiketais Medical Technology Co Ltd
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Abstract

The invention provides a human brain dynamic body-imitating device and a near-infrared optical instrument accuracy calibration method, which realize the function of calibrating the accuracy of a near-infrared optical detection device by simulating the test environment of a near-infrared optical instrument and accurately quantizing the characteristics, solve the problem that the near-infrared optical detection industry lacks inspection standards, provide effective inspection standards for near-infrared optical detection and lay a foundation for the development of the near-infrared spectrum standardization industry. Compared with animal experiments, the invention has the advantages of standardized production, repeated use, controllable parameters and stable and controllable working environment. The invention reduces the production cost and the detection cost and the medical cost.

Description

Human brain dynamic body-simulating device and near-infrared optical instrument accuracy calibration method
Technical Field
The invention belongs to the technical field of medical photoelectric monitoring, and particularly relates to a human brain dynamic body simulating device and a near-infrared optical instrument accuracy calibration method.
Background
Different organic matters contain different groups, different groups have different energy levels, different groups and the same group have obvious difference on the absorption wavelength of near infrared light in different physical and chemical environments, and the absorption coefficient is small, the heating is less, so the near infrared spectrum can be used as an effective carrier for acquiring information. When the near infrared light irradiates, the light rays and groups with the same frequency generate resonance phenomenon, and the energy of the light is transferred to molecules through the change of dipole moment of the molecules; the frequency of the near infrared light is different from the vibration frequency of the sample, and the infrared light of the frequency cannot be absorbed. Therefore, the skull is irradiated by the near-infrared light source with the wavelength of 600-900nm, the absorption effect information of the brain tissue on light is obtained by measuring the emergent light intensity after diffusion of the brain tissue according to the difference of the absorption of main chromophore substances (oxyhemoglobin, deoxyhemoglobin and cytochrome oxidase) in the brain tissue on the near-infrared spectrum, and the cerebral blood oxygen saturation can be obtained by adopting a related algorithm.
With the development of near infrared spectrum detection technology, a problem is gradually revealed. I.e., from research institutes to enterprises, lack industry-recognized standards of validity. Only after accepted inspection, the functional utility of the product is more objective and convincing. The current common test method is physical simulation or animal experiment. An industry standard for testing should have complete physical simulation observed quantity detection, so its priority is higher. The physical simulation is a method for realizing accurate quantification of the characteristics of the target detection quantity through physical device simulation after extracting the relevant characteristics of the target detection quantity. Compared with animal experiments, the advantages of the method are as follows: standardized production, repeated use, controllable parameters and stable and controllable working environment; in addition, the mass production can reduce the production cost, thereby reducing the detection cost and reducing the medical cost.
Therefore, there is a need for a physical device that simulates the activity of human brain chromophores to calibrate the reliability and accuracy of existing near-infrared optical detection devices as an industry standard for testing.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: the human brain dynamic body simulating device and the near infrared optical instrument accuracy calibrating method are provided for calibrating the accuracy of the near infrared optical detection device.
The technical scheme adopted by the invention for solving the technical problems is as follows: the human brain dynamic body-simulating device comprises a brain tissue physical environment simulation module, a chromophore simulation module, a motion control module and a human-computer interaction module; the brain tissue physical environment simulation module is provided with an instrument interface for connecting an instrument to be calibrated, and the inside of the brain tissue physical environment simulation module is filled with a fat emulsion Intralipid solution with the concentration of 1% for simulating the human brain tissue physical environment; the chromophore simulation module is assembled in the brain tissue physical environment simulation module and simulates the concentration change of the chromophore in the optical mode through the depth change of color, and is used for dynamically simulating the biological performances including absorption and scattering of light radiation generated by the chromophore in each region of the human brain when the brain moves; the signal output end of the man-machine interaction module is connected with the signal input end of the motion control module and used for sending a control instruction to the motion control module according to a pre-input brain function activity mode; the signal input end of the man-machine interaction module is connected with the signal output end of the instrument to be calibrated and is used for receiving, processing and displaying the test data and the calibration result of the instrument to be calibrated; the motion output end of the motion control module is connected with the chromophore simulation module and is used for driving the chromophore simulation module to simulate the motion of the brain activity; the chromophore emulation module comprises at least one movable color bar having a difference in color value; the color bar is a long rod made of a light-transmitting material, a plurality of annular color bands are sequentially distributed on the surface of the long rod from top to bottom, and the colors of the color bands are darkened or lightened by adjusting RGB values from top to bottom.
According to the scheme, the color bands of the same color bar adopt linearly-changed color spectrums, the color change degrees of the color bands are consistent, and the widths of the color bands are consistent; the color bars are classified according to the precision, and comprise high-precision color bars and low-precision color bars; the width of the color ribbon of the high-precision color bar is less than 10 mm; the width of the color ribbon of the low-precision color bar is more than or equal to 10mm and less than 30 mm; the higher the size and the detection precision of a sensor of the instrument to be calibrated are, the smaller the width of a single color band is, and the larger the measurement range of the instrument to be calibrated is, the larger the span of the color spectrum on the same color bar is; selecting the color and the shade of the color bar according to the target observed quantity of the instrument to be calibrated; if the target observed quantity is the blood oxygen saturation degree, selecting a red color bar; if the simulation is that the surface layer of the human brain has less activity and the deep layer has more activity, selecting a darkened color bar; if the simulation is that the surface layer of the human brain has more activity and the deep layer has less activity, selecting a color bar which becomes lighter; the color bar is in a solid shape obtained by normal stretching of a plane closed graph, and comprises a cylinder, a cuboid and a triangular prism; the surface of the color band is roughened by adopting a frosting process or smearing matte paint, and the surface is used for enhancing the scattering ability of the color band so as to simulate the absorption and reflection of chromophore to light; light transmissive materials include, but are not limited to, PMMA, PE, FEP.
According to the scheme, the brain tissue physical environment simulation module comprises a top box, wherein the top box is a closed container made of shading materials; the light-shielding material has light transmittance lower than 1% and is not easy to react with Intralipid solution, including but not limited to black ABS, PPO and POM; the surface of the top box is sprayed with black paint for absorbing light penetrating through the shading material; the top surface of the top box is provided with an instrument interface which is made of a light-transmitting material comprising PMMA; a hollow channel vertical to the top surface of the top box is arranged in the top box and is used for the color bar to reciprocate; the cross section shape of the hollow channel is matched with that of the color bar; the upper and lower surfaces of the top case have a usable area not smaller than the area of the human brain, and are set to 390 × 390mm2(ii) a The cross section area of the single hollow channel is smaller than
Figure BDA0003253609340000031
The height of the top box is more than 30mm, and the length of the color rod is longer than the height of the top box by a certain distance, so that the preset length of the color rod is ensured to extend into the top box; the hollow channels are parallel to each other; the hollow channels in each row are closely arranged, and the hollow channels in two adjacent rows are closely arranged in a staggered manner.
According to the scheme, the man-machine interaction module comprises a display unit, a data processing unit and a switch; the data processing unit comprises a communication module and a processor; the communication module is used for transmitting data with an upper computer or a remote platform; the processor is used for comparing the test data of the instrument to be calibrated with the pre-input brain function activity mode to obtain the accuracy of the instrument to be tested, or comparing the detection data of the sensor of the instrument to be calibrated with the pre-input brain function activity mode to obtain the calibration data of the sensor; the display unit is used for inputting instructions, consulting commands, displaying data and results; the switch is used for starting and stopping the operation of the human brain dynamic simulator.
According to the scheme, the device further comprises a mounting frame; the mounting frame comprises a base and a fixing bracket; the four corners of the base are provided with second supporting columns, the bottom surface of the fixing support is provided with second positioning grooves, the second supporting columns are assembled in the second positioning grooves, and the base and the fixing support are positioned through the second supporting columns and the second positioning grooves and are detachably connected; the top of the fixed support is provided with a first support column, the bottom of the top box is provided with a first positioning groove, the first support column is assembled in the first positioning groove, and the fixed support and the top box are positioned and detachably connected through a second support column and a second positioning groove; the man-machine interaction module is arranged inside the base; the top surface of base is equipped with the motor recess.
Further, the motion control module comprises a motion unit and a control unit; the motion unit comprises a lifting mechanism; the lifting mechanism is used for driving the color bar to do up-and-down reciprocating motion and comprises a bearing bracket, a screw rod, a guide rail, a sliding block and a motor; the guide rail is fixed between the bearing brackets; the screw rod is parallel to the guide rail, takes the central shaft as a rotating shaft and is connected between the bearing brackets through a bearing; the motor is assembled in the motor groove, and the bearing support is detachably connected and fixed on the top surface of the base and the bottom surface of the fixed support respectively; the sliding block is provided with two holes which are respectively sleeved on the screw rod and the guide rail, the hole sleeved with the screw rod is a threaded hole matched with the screw rod, and the hole sleeved with the guide rail is a through hole; the sliding block is also provided with an assembly hole A, and the assembly hole A is used for fixing the bottom of the color bar; the motor is arranged at the bottom of the bearing connected with the screw rod and used for driving the screw rod to rotate so as to enable the sliding block to do vertical linear motion; the motor is a servo motor; the control end of the control unit is connected with the controlled end of the motor and used for converting the received data into instructions and sending the instructions to the motor.
Furthermore, in order to simulate the human brain environment with less superficial blood oxygen activity and more deep blood oxygen activity including oxyhemoglobin and deoxyhemoglobin chromophore, the diameter of the color setting stick is 5mm, and the length is 120 mm; the height of the top box is 100 mm; the single color band width of the color setting bar is 5mm, and the total width of the color band is 30 mm; the color bar a is deeper from top to bottom, the color value range of the color bar a is sequentially RGB (255, 120, 120) -RGB (255, 100, 100), RGB (255, 100, 100) -RGB (255, 80, 80), RGB (255, 80, 80) -RGB (255, 60, 60), RGB (255, 60, 60) -RGB (255, 40, 40), RGB (255, 40, 40) -RGB (255, 20, 20), RGB (255, 20, 20) -RGB (255, 0, 0), and a linearly-changed color value is designed in each color bar and used for simulating an oxygenated hemoglobin chromophore; the color bar b is deeper from top to bottom, the color bar 5 sequentially has color values ranging from RGB (255, 120, 255) -RGB (255, 100, 255), RGB (255, 100, 255) -RGB (255, 80, 255), RGB (255, 80, 255) -RGB (255, 60, 255), RGB (255, 60, 255) -RGB (255, 40, 255), RGB (255, 40, 255) -RGB (255, 20, 255), RGB (255, 20, 255) -RGB (255, 0, 255), and the color bar 5 is designed with linearly changing color values inside each color bar to simulate a deoxyhemoglobin chromophore.
The precision calibration method of the near-infrared optical instrument comprises the following steps:
s1: the human brain dynamic body simulating device comprises a brain tissue physical environment simulation module, a chromophore simulation module, a motion control module and a human-computer interaction module; the brain tissue physical environment simulation module is provided with an instrument interface, and the inside of the brain tissue physical environment simulation module is filled with a 1% fat emulsion Intralipid solution; the chromophore simulation module is assembled in the brain tissue physical environment simulation module; the signal output end of the man-machine interaction module is connected with the signal input end of the motion control module; the signal input end of the man-machine interaction module is connected with the signal output end of the instrument to be calibrated; the motion output end of the motion control module is connected with the chromophore simulation module; the chromophore emulation module comprises at least one movable color bar having a difference in color value; the color bar is a long rod made of a light-transmitting material, and a plurality of annular color bands are sequentially distributed on the surface of the long rod from the top to the bottom; selecting a color bar to be installed according to the detection purpose and the target observed quantity;
s2: connecting an instrument to be calibrated to an instrument interface; inputting the corresponding brain function activity mode to a human-computer interaction module;
s3: the man-machine interaction module processes the data template and sends the data template to the motion control module;
s4: the motion control module receives data, converts the data into instructions and executes the instructions, and drives the color bars to reciprocate in the brain tissue physical environment simulation module to form different color bar combinations so as to complete the simulation of the chromophore;
s5: the instrument to be calibrated acquires data and sends the data to the man-machine interaction module;
s6: and the human-computer interaction module receives the acquired data and compares the acquired data with the brain function activity mode in the step S2 to obtain an accuracy report of the instrument to be calibrated.
Further, in step S1, the specific steps include:
s11: selecting a color bar according to the detection purpose and the target observed quantity;
s12: installing the color bar on a lifting mechanism of a motion control module to form a complete motion unit;
s13: sequentially installing the moving units between the base and the fixed support to enable the color rods to penetrate through the fixed support; a fixed base and a fixed bracket;
s14: inserting the color bar into the top box from the bottom, and fixing the top box and the fixing bracket;
s15: and the motion control module and the human-computer interaction module are connected.
Further, steps S5 and S6 are replaced with the following steps:
a sensor of an instrument to be calibrated acquires data and sends the data to a man-machine interaction module;
and the human-computer interaction module receives the acquired data and compares the acquired data with the brain function activity mode in the step S2 to obtain a reliability report.
The invention has the beneficial effects that:
1. according to the human brain dynamic body-simulating device and the near-infrared optical instrument accuracy calibration method, the function of calibrating the accuracy of the near-infrared optical detection device is realized by simulating the test environment of the near-infrared optical instrument and accurately quantifying the characteristics, the problem that the near-infrared optical detection industry lacks the inspection standard is solved, the effective inspection standard is provided for the near-infrared optical detection, and the foundation is laid for the development of the near-infrared spectrum standardization industry.
2. Compared with animal experiments, the invention has the advantages of standardized production, repeated use, controllable parameters and stable and controllable working environment.
3. The invention reduces the production cost and the detection cost and the medical cost.
Drawings
Fig. 1 is an exploded view of an assembly of an embodiment of the present invention.
Fig. 2 is a perspective view of a top case of an embodiment of the present invention.
Fig. 3 is a cross-sectional view of a top case of an embodiment of the present invention.
Fig. 4 is a front view of a color bar according to an embodiment of the present invention.
Fig. 5 is a perspective view of a lift module according to an embodiment of the present invention.
Fig. 6 is an assembly view of a color bar and a lift module according to an embodiment of the present invention.
Fig. 7 is a flow chart of an embodiment of the present invention.
In the figure: 1. a top box; 2. fixing a bracket; 3. a lifting mechanism; 4. a base; 5. a color bar; 6. a bearing support; 7. a screw rod; 8. a guide rail; 9. a slider; 10. a stepping motor; A. and (7) assembling holes.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.
Referring to fig. 1, an embodiment of the present invention includes a device body, a brain tissue physical environment simulation module, a chromophore simulation module, a human-computer interaction module, and a motion and control module.
The device main part includes base 4 and fixed bolster 2, and base 4 is provided with the recess of installation motion unit, and the motion unit passes through the screw fixation at base 4, and base 4 is provided with the support column, and fixed bolster 2 sets up the recess of assembly pillar, and base 4 and fixed bolster 2 pass through for screwed connection after pillar and the recess location, form the whole framework of device after the pillar in 4 four corners of base and the bottom recess location assembly of fixed bolster 2. The fixed support 2 is provided with a supporting column, the brain tissue physical environment simulation module is provided with a groove for assembling the supporting column, and the fixed support 2 is connected and fastened with the brain tissue physical environment simulation module through screws.
The brain tissue physical environment simulation module comprises a top box 1, and the top box 1 is installed on the upper portion of the fixing frame through screws. As shown in fig. 2, the top box 1 is a closed container made of a light-shielding material, and the light-shielding material has properties of high hardness, strong corrosion resistance, light transmittance lower than 1%, good wear resistance, stable chemical properties, and difficulty in reacting with an intralid solution, and includes but is not limited to materials such as black ABS, PPO, and POM; in order to ensure that the light transmittance is lower than 1%, black paint can be sprayed on the outer surface of the container to absorb light penetrating through the material. The upper cover of the top box 1 is provided with an external interface which can be connected with a probe and a light source of related detection equipment, the material of the interface is favorable for light rays such as near infrared light and the like to penetrate, and the polymethyl methacrylate PMMA material is selected.
As shown in fig. 3, a hollow cylindrical passage is provided inside the top case 1 as a passage through which the color bar 5 reciprocates. The inside of the top box 1 was filled with a 1% fat emulsion Intralipid solution to simulate the physical environment of human brain tissue. The maximum value of the head circumference is 680mm, so that the area of the human brain is obtained and is specifically set to 390 × 390mm as the using area of the upper surface and the lower surface of the top box 12. The optimal distance of the source probe for the reference near infrared detection is 30mm, so that the single occupied area of the cylindrical hollow channel is set to be
Figure BDA0003253609340000061
At present, the deepest distance of the brain of a human body is about 30mm, the detection depth is improved for ensuring that the activity of the human body can be completely detected and the technology is improved, the height of the top box 1 is higher than 30mm, and the height of the top box 1 is determined to be 100 mm. The shape of the cylindrical hollow channel of the brain tissue physical environment simulation module is not limited to a cylinder, and closed shapes such as a diamond shape, a triangle shape, a hexagon shape and the like are also suitable. The total number of the cylindrical hollow channels is 618, the first row is provided with 13 cylindrical hollow channels, the second row is provided with 12 cylindrical hollow channels which are arranged backwards from the middle position of the two cylindrical hollow channels in the front of the first row, the cylindrical hollow channels in each row are arranged in a zero-gap mode, and the cylindrical hollow channels in two adjacent rows are arranged in a zero-gap modeThe two arrangement modes are staggered and arrayed, and 13 rows are formed in total. The staggered arrangement between two adjacent rows is to establish more detection channels, and compared with the condition that each row is arranged consistently, the detection channels of the same color bar 5 are at least two more channels arranged by 15mm in a staggered manner. The bottom of the external interface of the brain tissue physical environment simulation module and the cylindrical hollow channel are made of transparent materials. The material should have the properties of high light transmittance, low haze, good weather resistance, and permeability to near infrared rays, including but not limited to PE, FEP, PMMA, and the like.
The chromophore simulation module comprises at least one adjustable color bar 5 with color value difference and different color combinations, and is used for simulating the biological performance of absorption and scattering of light radiation when chromophores in various regions of a human brain perform brain activities, so as to realize dynamic simulation of the brain activities. The color bar 5 is a long rod made of transparent material, including but not limited to PMMA, PE, FEP, etc. The surface of the long rod is distributed with an annular color band from the top to the bottom, the color of the color band becomes dark or light from top to bottom, and the color depth is adjusted by adjusting the RGB value. The same long rod has only one color, the color bands have the same width, the color can be changed from one color to the other color in a deepening or lightening mode, and the color change degrees of the color bands are the same. In this embodiment, red is selected, the width of the color band is 5mm, and the color is lighter from top to bottom.
The color bars 5 are also classified according to the precision, the color bands of the high-precision color bars are narrow, and the width is generally more than or equal to 5mm and less than 10 mm; the color band width of the low-precision color bar is generally more than or equal to 10mm and less than 30 mm. The division is based on the precision of the sensor, the precision of the sensor is high, the precision is high, and the color and the shade change in the narrow color band can be clearly distinguished; on the other hand, if the sensor accuracy is low, the accuracy is low, and the color and shade variation of the narrow color band are difficult to be discriminated, and only the color and shade variation of the wide color band can be roughly discriminated. According to the existing literature, the near infrared spectrum detects that the depth of the human brain reaches 3cm below the cerebral cortex at most, so the width of a color band does not exceed 3cm, the detection precision of the current near infrared sensor is known, the width of the color band cannot be lower than 5mm, and the single width and the total width of a color ring can be continuously adjusted according to the upgrade of the near infrared sensor and the improvement of the detection precision; the single width of the color band can be continuously reduced along with the size of the near infrared sensor and the upgrading and the renovation of the detection precision, and the total width of the color band can be continuously widened along with the increase of the detection depth of the near infrared spectrum detection technology. The shape of the color bar 5 includes, but is not limited to, a cylinder, a rectangular parallelepiped, a triangular prism, and the like, which are solid shapes obtained by stretching a planar closed figure.
The chromophore simulation module simulates the concentration change of the chromophore in the optical mode through the depth of the color; the capability of the color bar 5 for absorbing and scattering light is changed by changing the material or the processing technology of the color band; such as roughening the ribbon surface by a frosting process or applying a matte finish to increase the diffuse reflection of light and thus enhance the scattering ability of the ribbon. The color of the color bar is selected according to the target observed quantity required by detection, and if the observed quantity is the blood oxygen saturation, the red color bar 5 is preferentially selected to simulate red blood cells. Meanwhile, the color bar 5 with the color being darker or lighter is selected according to the detection purpose, for example, if the simulated brain blood oxygen activity is less on the surface layer and frequent in the deep layer, the color bar 5 with the color being darker is selected; if the simulation shows that the surface layer of the brain blood oxygen activity of the human is more active and the deep layer is not frequent, the color bar 5 which becomes lighter is selected.
As shown in FIG. 4, a long rod made of light-transmitting material polymethyl methacrylate PMMA is selected, the diameter is 5mm, and the total length is 120 mm. The 20mm length above the height of the top box 1 is to ensure that a 100mm length will be able to fully enter the top box 1 in the event of error or structural limitations. The environment simulated by this example is less superficial blood oxygenation activity and more deep blood oxygenation activity, including the oxyhemoglobin and deoxyhemoglobin chromophore. Therefore, color values of color bands of RGB (255, 120, 120) -RGB (255, 100, 100), RGB (255, 100, 100) -RGB (255, 80, 80), RGB (255, 80, 80) -RGB (255, 60, 60), RGB (255, 60, 60) -RGB (255, 40, 40), RGB (255, 40, 40) -RGB (255, 20, 20), RGB (255, 20, 20) -RGB (255, 0, 0) are sequentially selected from the top to the bottom in a simulated oxyhemoglobin mode, the color bars 5 with linearly changing color values are designed in the color bands, each color band is 5mm wide, the total width of the color bands is 30mm, and the color bars 5 are called color bars a. The color of the color bar darkens from top to bottom, simulating the oxygenated hemoglobin chromophore. The simulated deoxyhemoglobin adopts color bars 5 with color values of RGB (255, 120, 255) -RGB (255, 100, 255), RGB (255, 100, 255) -RGB (255, 80, 255), RGB (255, 80, 255) -RGB (255, 60, 255), RGB (255, 60, 255) -RGB (255, 40, 255), RGB (255, 40, 255) -RGB (255, 20, 255), RGB (255, 20, 255) and RGB (255, 20, 255) -RGB (255, 0, 255) in sequence from top to bottom, the color bars 5 with linearly changing color values are designed in each color bar, each color bar is 5mm wide, the total width of the color bar is 30mm, and the color bar 5 is called a color bar b. The color of the color bar darkens from top to bottom, mimicking the deoxyhemoglobin chromophore.
The man-machine interaction module comprises a display unit, a CPU data analysis and processing unit and a device body switch, wherein the CPU data analysis and processing unit comprises a data analysis and transmission chip and a terminal CPU which are positioned in the base 4, and the display unit comprises a display screen of the base 4 and a terminal display screen. The human-computer interaction module inputs the brain function activity mode through the CPU data analysis and processing unit. The CPU data analysis and processing unit transmits the processed data to the motion and control module. The detection device collects related data such as blood oxygen and the like and inputs the data into the CPU data analysis and processing unit, and the CPU data analysis and processing unit compares the detection data with the movable data template to obtain the accuracy of the measured instrument. The detection data of a sensor at a certain position detected by the detected instrument can also be compared with the real-time data through the CPU data analysis and processing unit.
The display unit comprises a display screen on the device base 4 and a display screen of an upper computer, and can input instructions and look up data.
The motion and control module comprises a motion unit and a control unit; the control unit comprises an integrated chip which is positioned at the lower end of the motor and is placed in the base 4, and the control unit forms a command with the received data and then is executed by the motion unit; the moving unit is positioned and installed with the base 4 and the fixed bracket 2 through screws, and comprises a lifting mechanism 3 and an actuating element color bar 5; the lifting mechanism 3 comprises a power source motor and a lifting component, the whole lifting mechanism 3 is based on the principle of a screw rod guide rail sliding block, the motor drives the screw rod 7 to rotate and convert the rotation into the linear motion of the sliding block 9, and the guide rail 8 plays a role in positioning and guiding. As shown in fig. 5, the lifting mechanism 3 includes a bearing bracket 6, a screw rod 7, a guide rail 8, a slider 9, and a stepping motor 10; in order to ensure that the stroke is controllable and convenient to adjust, a servo motor is generally selected as the motor; the lifting component comprises but is not limited to a sliding screw rod, a belt transmission component, a hydraulic transmission component and other transmission components, and a reciprocating motion mechanism such as a connecting rod mechanism, a driving cylinder driving column, a hydraulic push rod and the like; in the embodiment, the lifting mechanism 3 is formed by a servo motor and a sliding screw rod. As shown in fig. 6, the position a, i.e. the color bar fixing position, is a complete moving unit formed by installing the color bar 5 on the position a of the slide block 9 of the lifting mechanism 3.
The working principle of the device is as follows: brain function activity data is input in a CPU data analysis and processing unit through a man-machine interaction module in advance, and the CPU data analysis and processing unit transmits the processed data to a motion and control module. The motion and control module comprises a motion unit and a control unit respectively, the control unit forms a command with the received data and then is executed by the motion unit, so that the color bar 5 which is a main execution part in the motion unit reciprocates, and different color bars 5 are combined to form the chromophore module; then, the near infrared and other related detection devices are connected through an external interface designed by the device, and the detection devices can judge the accuracy of the instrument to be detected by acquiring the data such as the blood oxygen related to the dynamic simulator and comparing the data with a brain function activity data standard template which is input in a CPU data analysis and processing unit in advance. Meanwhile, the detection data of a certain sensor detected by the detected instrument can also be compared in real time through the device.
Referring to fig. 7, the detection method of the present invention includes the following steps:
s1: installing the device, and connecting the near-infrared detection equipment to be detected to an external interface of the device; selecting a color bar 5 and brain function activity data according to the detection purpose and the target observed quantity;
s11: mounting the selected color bar 5 on the lifting mechanism 3 to form a complete motion unit;
s12: the moving units are sequentially installed on the base 4, then the fixed support 2 is installed, and finally the top box 1 is installed.
S2: inputting a brain function activity mode to a CPU data analysis and processing unit of the human-computer interaction module, processing data by the CPU data analysis and processing unit and transmitting the data to the motion and control module;
s3: the control unit of the motion and control module receives the data, converts the data into instructions and then sends the instructions to the motion unit; the moving unit executes the instruction, controls the lifting mechanism 3 to drive the color bar 5 to reciprocate to form different color bar combinations, and completes the simulation of the chromophore;
s4: the access equipment acquires data including blood oxygen of brain activity simulated by the dynamic body simulator, inputs the data into the CPU data analysis and processing unit, and compares the data with a brain function activity mode input in advance to obtain an accuracy report of the access equipment; the sensor data of the access equipment is also compared with the data in real time through the device to obtain a reliability report.
The above embodiments are only used for illustrating the design idea and features of the present invention, and the purpose of the present invention is to enable those skilled in the art to understand the content of the present invention and implement the present invention accordingly, and the protection scope of the present invention is not limited to the above embodiments. Therefore, all equivalent changes and modifications made in accordance with the principles and concepts disclosed herein are intended to be included within the scope of the present invention.

Claims (10)

1.人脑动态仿体装置,其特征在于:包括脑组织物理环境模拟模块、生色团模拟模块、运动控制模块、人机交互模块;脑组织物理环境模拟模块设有仪器接口用于连接待标定仪器,内部充满浓度为1%的脂肪乳剂Intralipid溶液用于模拟人的脑组织物理环境;生色团模拟模块装配在脑组织物理环境模拟模块中通过颜色的深浅变化模拟生色团在光的模态下的浓度变化,用于动态模拟人脑各个区域的生色团在进行脑部活动时对光辐射产生的包括吸收、散射的生物学性能;人机交互模块的信号输出端连接运动控制模块的信号输入端,用于根据预输入的脑功能活动模式向运动控制模块发送控制指令;人机交互模块的信号输入端连接待标定仪器的信号输出端,用于接收、处理、显示待标定仪器的测试数据和标定结果;运动控制模块的动作输出端连接生色团模拟模块,用于驱动生色团模拟模块进行模拟脑部活动的动作;1. Human brain dynamic imitation device, it is characterized in that: comprise brain tissue physical environment simulation module, chromophore simulation module, motion control module, human-computer interaction module; Brain tissue physical environment simulation module is provided with an instrument interface for connecting to be The calibration instrument is filled with 1% fat emulsion Intralipid solution to simulate the physical environment of human brain tissue; the chromophore simulation module is assembled in the simulation module of the physical environment of brain tissue to simulate the chromophore in the light through the change of color depth. The concentration change under the mode is used to dynamically simulate the biological properties including absorption and scattering of light radiation produced by chromophores in various regions of the human brain during brain activities; the signal output end of the human-computer interaction module is connected to motion control The signal input end of the module is used to send control commands to the motion control module according to the pre-input brain function activity mode; the signal input end of the human-computer interaction module is connected to the signal output end of the instrument to be calibrated, and is used to receive, process and display the to-be-calibrated instrument. The test data and calibration results of the instrument; the action output end of the motion control module is connected to the chromophore simulation module, which is used to drive the chromophore simulation module to simulate brain activity; 生色团模拟模块包括至少一个活动的、具有色值差异的色棒;色棒是由透光材料制成的长杆,长杆表面自顶部向下依次分布若干环状的色带,色带的颜色自上而下通过调整RGB值变深或变浅。The chromophore simulation module includes at least one active color rod with color value difference; the color rod is a long rod made of light-transmitting material, and the surface of the long rod is distributed with several annular color bands from top to bottom. The colors are made darker or lighter from top to bottom by adjusting the RGB values. 2.根据权利要求1所述的人脑动态仿体装置,其特征在于:2. human brain dynamic imitation device according to claim 1, is characterized in that: 同一根色棒的色带采用线性变化的色谱,色带的颜色变化程度一致、色带的宽度一致;The ribbon of the same color bar adopts a linearly changing chromatogram, the color change degree of the ribbon is the same, and the width of the ribbon is the same; 色棒以精度高低分类,包括高精度色棒和低精度色棒;高精度色棒的色带的宽度小于10mm;低精度色棒的色带的宽度大于等于10mm且小于30mm;待标定仪器的传感器的尺寸和检测精度越高则单个色带的宽度越小,待标定仪器的测量范围越大则同一根色棒上的色谱的跨度越大;Color bars are classified according to their accuracy, including high-precision color bars and low-precision color bars; the width of the ribbon of the high-precision color bar is less than 10mm; the width of the ribbon of the low-precision color bar is greater than or equal to 10mm and less than 30mm; The higher the size and detection accuracy of the sensor, the smaller the width of a single ribbon, and the larger the measurement range of the instrument to be calibrated, the larger the chromatogram span on the same color bar; 色棒的颜色、深浅根据待标定仪器的目标观测量选择;若目标观测量为血氧饱和度,则选择红色的色棒;若模拟的是人脑表层活动少,深层活动多,则选择变深的色棒;若模拟的是人脑表层活动多,深层活动少,则选择变浅的色棒;The color and depth of the color bar are selected according to the target observation of the instrument to be calibrated; if the target observation is blood oxygen saturation, select the red color bar; if the simulation is that the human brain has less surface activity and more deep activity, select variable. Dark color bar; if the simulation is that there is more activity in the surface layer of the human brain and less activity in the deep layer, choose a lighter color bar; 色棒的形状为由平面闭合图形法向拉伸得到的实体形状,包括圆柱、长方体、三棱柱;The shape of the color bar is a solid shape obtained by normal stretching of a plane closed figure, including a cylinder, a cuboid, and a triangular prism; 色带的表面采用磨砂工艺或涂抹哑光漆使色带表面粗糙,用于增强色带的散射能力从而模拟生色团对光的吸收和反射;The surface of the ribbon is roughened by a frosting process or matte paint is applied to enhance the scattering ability of the ribbon to simulate the absorption and reflection of light by chromophores; 透光材料包括但不限于PMMA、PE、FEP。Light-transmitting materials include but are not limited to PMMA, PE, and FEP. 3.根据权利要求1所述的人脑动态仿体装置,其特征在于:3. human brain dynamic imitation device according to claim 1, is characterized in that: 脑组织物理环境模拟模块包括顶箱,顶箱是由遮光材料制成的封闭容器;The brain tissue physical environment simulation module includes a top box, which is a closed container made of shading material; 遮光材料的透光率低于1%且不易与Intralipid溶液反应,包括但不限于黑色ABS、PPO、及POM;The light transmittance of the shading material is less than 1% and it is not easy to react with the Intralipid solution, including but not limited to black ABS, PPO, and POM; 顶箱的表面喷涂黑漆用于吸收透过遮光材料的光线;The surface of the top box is sprayed with black paint to absorb the light passing through the shading material; 顶箱的顶面设有仪器接口,仪器接口的选用包括PMMA的透光材料;The top surface of the top box is provided with an instrument interface, and the selection of the instrument interface includes the light-transmitting material of PMMA; 顶箱的内部设有与顶箱的顶面垂直的空心通道用于供色棒进行往复运动;空心通道的截面形状与色棒的截面形状相匹配;The interior of the top box is provided with a hollow channel perpendicular to the top surface of the top box for the reciprocating motion of the color bar; the cross-sectional shape of the hollow channel matches that of the color bar; 顶箱的上下表面的使用面积不小于人脑面积,设置为390*390mm2The use area of the upper and lower surfaces of the top box is not less than the area of the human brain, and is set to 390*390mm 2 ; 设置单个空心通道的截面积小于
Figure FDA0003253609330000021
Set the cross-sectional area of a single hollow channel to be less than
Figure FDA0003253609330000021
顶箱的高度大于30mm,且使色棒的长度比顶箱的高度长一定距离,用于保证色棒的预设长度伸入顶箱;The height of the top box is greater than 30mm, and the length of the color bar is longer than the height of the top box by a certain distance to ensure that the preset length of the color bar extends into the top box; 空心通道之间相互平行;每行空心通道之间紧密排列,相邻两行空心通道之间交错紧密排列。The hollow channels are parallel to each other; the hollow channels in each row are closely arranged, and the hollow channels in two adjacent rows are staggered and closely arranged.
4.根据权利要求1所述的人脑动态仿体装置,其特征在于:4. human brain dynamic imitation device according to claim 1, is characterized in that: 人机交互模块包括显示单元、数据处理单元和开关;The human-computer interaction module includes a display unit, a data processing unit and a switch; 数据处理单元包括通信模块和处理器;The data processing unit includes a communication module and a processor; 通信模块用于与上位机或远程平台传输数据;The communication module is used to transmit data with the host computer or remote platform; 处理器用于比对待标定仪器的测试数据和预输入的脑功能活动模式得到被测仪器的精确度,或比对待标定仪器的传感器的检测数据和预输入的脑功能活动模式得到传感器标定数据;The processor is used for comparing the test data of the instrument to be calibrated and the pre-input brain function activity pattern to obtain the accuracy of the instrument under test, or comparing the detection data of the sensor to be calibrated and the pre-input brain function activity pattern to obtain sensor calibration data; 显示单元用于输入指令、查阅命令、显示数据和结果;The display unit is used for inputting instructions, viewing commands, displaying data and results; 开关用于启动和停止人脑动态仿体装置的运行。The switch is used to start and stop the operation of the human brain dynamic imitation device. 5.根据权利要求1所述的人脑动态仿体装置,其特征在于:5. human brain dynamic imitation device according to claim 1, is characterized in that: 还包括安装框架;安装框架包括底座和固定支架;Also includes a mounting frame; the mounting frame includes a base and a fixing bracket; 底座的四角设有第二支柱,固定支架的底面设有第二定位凹槽,第二支柱装配在第二定位凹槽中,底座与固定支架通过第二支柱和第二定位凹槽定位并可拆卸式连接;The four corners of the base are provided with second pillars, the bottom surface of the fixing bracket is provided with a second positioning groove, the second pillar is assembled in the second positioning groove, and the base and the fixing bracket can be positioned and can be positioned through the second pillar and the second positioning groove. detachable connection; 固定支架的顶部设有第一支柱,顶箱的底部的设有第一定位凹槽,第一支柱装配在第一定位凹槽中,固定支架与顶箱通过第二支柱和第二定位凹槽定位并可拆卸式连接;The top of the fixing bracket is provided with a first pillar, the bottom of the top box is provided with a first positioning groove, the first pillar is assembled in the first positioning groove, and the fixing bracket and the top box pass through the second pillar and the second positioning groove Positioning and detachable connection; 人机交互模块设置在底座的内部;底座的顶面设有电机凹槽。The human-computer interaction module is arranged inside the base; the top surface of the base is provided with a motor groove. 6.根据权利要求5所述的人脑动态仿体装置,其特征在于:6. human brain dynamic imitation device according to claim 5, is characterized in that: 运动控制模块包括运动单元和控制单元;The motion control module includes a motion unit and a control unit; 运动单元包括升降机构;升降机构用于驱动色棒做上下往复运动,升降机构包括轴承支架、丝杆、导轨、滑块、电机;The movement unit includes a lifting mechanism; the lifting mechanism is used to drive the color bar to reciprocate up and down, and the lifting mechanism includes a bearing bracket, a screw rod, a guide rail, a slider, and a motor; 导轨固定在轴承支架之间;丝杆与导轨平行、以中心轴为旋转轴、通过轴承连接在轴承支架之间;电机装配在电机凹槽中,轴承支架分别可拆卸式连接固定在底座的顶面和固定支架的底面;滑块设有两个孔,分别套装在丝杆与导轨上,套装丝杆的孔为与丝杆配合的螺纹孔,套装导轨的孔为通孔;滑块还设有A装配孔,A装配孔用于固定色棒的底部;The guide rail is fixed between the bearing brackets; the screw rod is parallel to the guide rail, takes the central axis as the rotation axis, and is connected between the bearing brackets through the bearing; the motor is assembled in the motor groove, and the bearing brackets are respectively detachably connected and fixed on the top of the base. and the bottom surface of the fixed bracket; the slider is provided with two holes, which are respectively sleeved on the screw rod and the guide rail, the hole of the sleeved screw rod is a threaded hole matched with the screw rod, and the hole of the sleeved guide rail is a through hole; There are A mounting holes, which are used to fix the bottom of the color bar; 电机设置在连接丝杆的轴承底部,用于驱动丝杆转动使滑块做上下直线运动;电机选用伺服电机;The motor is arranged at the bottom of the bearing connecting the screw rod, which is used to drive the screw rod to rotate to make the slider move up and down in a straight line; the motor is a servo motor; 控制单元的控制端连接电机的受控端,用于将收到的数据转换为指令并发送给电机。The control end of the control unit is connected to the controlled end of the motor, and is used to convert the received data into commands and send them to the motor. 7.根据权利要求2、3、5中任意一项所述的人脑动态仿体装置,其特征在于:为模仿表层血氧活动少、深层血氧活动多包括氧合血红蛋白和脱氧血红蛋白生色团的人脑环境,设色棒的直径为5mm,长度为120mm;顶箱的高度为100mm;设色棒的单个色带宽为5mm、色带总宽为30mm;7. The human brain dynamic phantom device according to any one of claims 2, 3, and 5, characterized in that: in order to imitate the surface blood oxygen activity is less, the deep blood oxygen activity mostly comprises oxyhemoglobin and deoxyhemoglobin chromogenesis In the human brain environment of the group, the diameter of the color bar is 5mm and the length is 120mm; the height of the top box is 100mm; the single color band of the color bar is 5mm, and the total width of the color band is 30mm; 设色棒a的色带自上而下变深,色带色值范围依次为RGB(255,120,120)~RGB(255,100,100)、RGB(255,100,100)~RGB(255,80,80)、RGB(255,80,80)~RGB(255,60,60)、RGB(255,60,60)~RGB(255,40,40)、RGB(255,40,40)~RGB(255,20,20)、RGB(255,20,20)~RGB(255,0,0),各个色带内部设计线性变化的色值,用于模拟氧合血红蛋白生色团;Let the color band of color bar a become darker from top to bottom, and the color value range of the color band is RGB(255, 120, 120) ~ RGB (255, 100, 100), RGB (255, 100, 100) ~ RGB ( 255, 80, 80), RGB (255, 80, 80) ~ RGB (255, 60, 60), RGB (255, 60, 60) ~ RGB (255, 40, 40), RGB (255, 40, 40) ) ~ RGB (255, 20, 20), RGB (255, 20, 20) ~ RGB (255, 0, 0), linearly changing color values are designed inside each color band to simulate the oxyhemoglobin chromophore; 设色棒b的色带自上而下变深,色带色值范围依次为RGB(255,120,255)~RGB(255,100,255)、RGB(255,100,255)~RGB(255,80,255)、RGB(255,80,255)~RGB(255,60,255)、RGB(255,60,255)~RGB(255,40,255)、RGB(255,40,255)~RGB(255,20,255)、RGB(255,20,255)~RGB(255,0,255)的色棒5,各个色带内部设计线性变化的色值,用于模拟脱氧血红蛋白生色团。Let the color band of color bar b become darker from top to bottom. 255, 80, 255), RGB (255, 80, 255) ~ RGB (255, 60, 255), RGB (255, 60, 255) ~ RGB (255, 40, 255), RGB (255, 40, 255) ) ~ RGB (255, 20, 255), RGB (255, 20, 255) ~ RGB (255, 0, 255) color bar 5, each color band is designed with linearly changing color values, used to simulate the production of deoxyhemoglobin chromophore. 8.基于权利要求1至7中任意一项所述的人脑动态仿体装置的近红外光学仪器精确度标定方法,其特征在于:包括以下步骤:8. based on the near-infrared optical instrument precision calibration method of the human brain dynamic phantom device described in any one of claims 1 to 7, it is characterized in that: comprise the following steps: S1:安装人脑动态仿体装置,包括脑组织物理环境模拟模块、生色团模拟模块、运动控制模块、人机交互模块;脑组织物理环境模拟模块设有仪器接口,内部充满浓度为1%的脂肪乳剂Intralipid溶液;生色团模拟模块装配在脑组织物理环境模拟模块中;人机交互模块的信号输出端连接运动控制模块的信号输入端;人机交互模块的信号输入端连接待标定仪器的信号输出端;运动控制模块的动作输出端连接生色团模拟模块;生色团模拟模块包括至少一个活动的、具有色值差异的色棒;色棒是由透光材料制成的长杆,长杆表面自顶部向下依次分布若干环状的色带;根据检测目的和目标观测量选择色棒安装;S1: Install a human brain dynamic imitation device, including a brain tissue physical environment simulation module, a chromophore simulation module, a motion control module, and a human-computer interaction module; the brain tissue physical environment simulation module is equipped with an instrument interface, and the internal filling concentration is 1% The chromophore simulation module is assembled in the brain tissue physical environment simulation module; the signal output end of the human-computer interaction module is connected to the signal input end of the motion control module; the signal input end of the human-computer interaction module is connected to the instrument to be calibrated The signal output end of the motion control module; the action output end of the motion control module is connected to the chromophore simulation module; the chromophore simulation module includes at least one active color rod with color value difference; the color rod is a long rod made of light-transmitting material , the surface of the long rod is distributed with a number of ring-shaped ribbons from the top down in turn; the color rod installation is selected according to the detection purpose and target observation; S2:将待标定仪器接入仪器接口;将对应的脑功能活动模式输入向人机交互模块;S2: Connect the instrument to be calibrated to the instrument interface; input the corresponding brain function activity mode to the human-computer interaction module; S3:人机交互模块处理数据模板并发送给运动控制模块;S3: The human-computer interaction module processes the data template and sends it to the motion control module; S4:运动控制模块接收数据、转换为指令并执行指令,驱动色棒在脑组织物理环境模拟模块中进行往复运动形成不同的色棒组合,完成对生色团的模拟;S4: The motion control module receives the data, converts it into an instruction, executes the instruction, and drives the color bar to reciprocate in the brain tissue physical environment simulation module to form different color bar combinations to complete the chromophore simulation; S5:待标定仪器采集数据并发送给人机交互模块;S5: The to-be-calibrated instrument collects data and sends it to the human-computer interaction module; S6:人机交互模块接收采集数据并与步骤S2的脑功能活动模式比对,得到待标定仪器的精确度报告。S6: The human-computer interaction module receives the collected data and compares it with the brain function activity pattern in step S2 to obtain an accuracy report of the instrument to be calibrated. 9.根据权利要求8所述的近红外光学仪器精确度标定方法,其特征在于:所述的步骤S1中,具体步骤为:9. The near-infrared optical instrument accuracy calibration method according to claim 8, wherein: in the step S1, the specific steps are: S11:根据检测目的和目标观测量选择色棒;S11: Select a color bar according to the detection purpose and target observation amount; S12:将色棒安装到运动控制模块的升降机构上,形成完整的运动单元;S12: Install the color bar on the lifting mechanism of the motion control module to form a complete motion unit; S13:将运动单元依次安装到底座和固定支架之间,使色棒穿过固定支架;固定底座和固定支架;S13: Install the motion unit between the base and the fixed bracket in turn, so that the color bar passes through the fixed bracket; fix the base and the fixed bracket; S14:将色棒从底部插入顶箱,固定顶箱和固定支架;S14: Insert the color bar into the top box from the bottom, and fix the top box and the fixing bracket; S15:连接运动控制模块和人机交互模块。S15: Connect the motion control module and the human-computer interaction module. 10.根据权利要求8所述的近红外光学仪器精确度标定方法,其特征在于:将步骤S5和S6替换为以下步骤:10. The near-infrared optical instrument accuracy calibration method according to claim 8, wherein steps S5 and S6 are replaced by the following steps: 待标定仪器的传感器采集数据并发送给人机交互模块;The sensor of the instrument to be calibrated collects data and sends it to the human-computer interaction module; 人机交互模块接收采集数据并与步骤S2的脑功能活动模式比对,得到可靠性报告。The human-computer interaction module receives the collected data and compares it with the brain function activity pattern in step S2 to obtain a reliability report.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118717057A (en) * 2024-09-02 2024-10-01 丹阳慧创医疗设备有限公司 A phantom device for measuring the performance of optical transmission pathways in near-infrared brain functional imaging equipment
CN118717056A (en) * 2024-09-02 2024-10-01 丹阳慧创医疗设备有限公司 Phantom device for measuring the performance of optical transmission path in near-infrared brain functional imaging equipment and method for measuring using the phantom device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4907876A (en) * 1987-05-08 1990-03-13 Hamamatsu Photonics Kabushiki Kaisha Examination apparatus for measuring oxygenation in body organs
CN109998559A (en) * 2019-04-24 2019-07-12 深圳市太赫兹科技有限公司 A kind of Near-infrared Brain oxygen detection system and method
WO2020100370A1 (en) * 2018-11-16 2020-05-22 株式会社島津製作所 Phantom device for optical brain function measurement device
CN111839531A (en) * 2020-07-22 2020-10-30 武汉爱可泰思医疗科技有限公司 Brain detection device
CN112641444A (en) * 2020-12-10 2021-04-13 中国科学院深圳先进技术研究院 Cerebral blood oxygen detection system and method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4907876A (en) * 1987-05-08 1990-03-13 Hamamatsu Photonics Kabushiki Kaisha Examination apparatus for measuring oxygenation in body organs
WO2020100370A1 (en) * 2018-11-16 2020-05-22 株式会社島津製作所 Phantom device for optical brain function measurement device
CN109998559A (en) * 2019-04-24 2019-07-12 深圳市太赫兹科技有限公司 A kind of Near-infrared Brain oxygen detection system and method
CN111839531A (en) * 2020-07-22 2020-10-30 武汉爱可泰思医疗科技有限公司 Brain detection device
CN112641444A (en) * 2020-12-10 2021-04-13 中国科学院深圳先进技术研究院 Cerebral blood oxygen detection system and method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘光达;曹泽元;周葛;周晓宇;蔡靖;查雨彤;千承辉;: "基于近红外光谱的抗扰动脑血氧分析仪", 光学精密工程, no. 08, 15 August 2016 (2016-08-15) *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118717057A (en) * 2024-09-02 2024-10-01 丹阳慧创医疗设备有限公司 A phantom device for measuring the performance of optical transmission pathways in near-infrared brain functional imaging equipment
CN118717056A (en) * 2024-09-02 2024-10-01 丹阳慧创医疗设备有限公司 Phantom device for measuring the performance of optical transmission path in near-infrared brain functional imaging equipment and method for measuring using the phantom device

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