CN113768496B - Device for monitoring motion state of biological body surface or bionic body inner surface - Google Patents

Abstract

The invention provides a device for monitoring the motion state of the surface of an organism or the inner surface of a bionic body, which is characterized in that after macromolecular polymer sol is coated and dried on the surface of the organism or the inner surface of the bionic body, an electric connector is prepared on the surface of the organism or the inner surface of the bionic body by using a liquid metal composite material doped with modified graphene, and a motion state monitoring, energy supplying and controlling module is attached. The device preparation is simple, the security is high, and the liquid metal combined material that modified graphene mixes has good carrier adaptability, and does not need extra surface packaging to handle, and the electric connector of preparation has high conductivity and flexibility, can satisfy the demand of monitoring motion state.

Description

A device for monitoring the movement state of the surface of a biological body or the surface of a bionic body

technical field

The invention belongs to the technical field of electronic material preparation and device processing, and in particular relates to a device for monitoring the movement state of a biological surface or a bionic internal surface.

Background technique

At present, flexible technology is regarded as one of the mainstream interactive forms of next-generation intelligent hardware, and flexible devices are also growing rapidly on an exponential scale. The rapid development of flexible devices has aroused great interest in many applications, such as health monitoring devices, electronic skin, and implantable devices. At the same time, the popularization of the concept of healthy China also requires more and more convenient detection devices, which can monitor the movement status of the surface and interior of organisms in real time, which is helpful to quickly and comprehensively grasp the functional characteristics of organisms, which is very important for improving health. Quality is very necessary. Among them, the quality of electrical connectors is crucial to the real-time monitoring of the movement status of organisms. The elasticity, bendability and stretchability of the flexible electrical connector can well adapt to the stretching and bending of the epidermis and tissue of the organism, so that the device prepared by it can measure the motion state of the surface of the organism in real time and accurately. At the same time, the bionic body prepared by 3D printing can imitate the physical and chemical properties of the biological body by selecting acrylic resin materials with similar physical and chemical properties to the biological body, and achieve the purpose of truly simulating the characteristics of the biological body. Real-time monitoring of the movement state of the biological endosome provides an effective means for in-depth research on the movement state of the living body.

Liquid metal itself has good electrical conductivity and is in a liquid state at room temperature, so it can be used as a flexible conductive material and a flexible electrical connector can be made by printing. The electrical connector made of liquid metal has many advantages such as being able to be rapidly manufactured, being environmentally friendly, and can be used to make a flexible, bendable, and stretchable electrical connector. However, the electrical connector made of liquid metal needs to use a certain packaging technology to isolate the wire from the external environment and avoid oxidation or physical damage to the liquid metal wire. At present, materials such as PDMS or silica gel are usually used to prepare electrical connectors from liquid metals. Fill uncured PDMS or silica gel materials into the surface of electrical connectors prepared from liquid metals, and use high temperature or natural curing to solidify the packaging materials and protect the electrical connectors. The role of connectors. This method needs to wait for a long time, and because of the natural curing method, it is difficult to guarantee the thickness and uniformity of the package. At the same time, liquid metal has a high selectivity for preparing carriers, which further limits its application and promotion.

Contents of the invention

Based on the existing technical problems described in the background technology, the object of the present invention is to provide a device for monitoring the movement state of the surface of a living body or the surface of a bionic interior, which is coated with a high-viscosity polymer sol on the surface of a living body or the surface of a bionic interior. 1. Obtain a polymer cured film after drying, and then use the modified graphene-doped liquid metal composite material to prepare an electrical connector on its surface, and mount the motion state monitoring, energy supply and control modules. The device is simple to prepare and has high safety. The modified graphene-doped liquid metal composite material used has good carrier adaptability, and can prepare uniform and stable electrical connectors on the surface of the polymer cured film without Requires additional surface encapsulation treatment and has a wide range of applications. At the same time, the prepared electrical connector has high conductivity and flexibility, which can meet the application requirements of monitoring the movement state of the surface of the biological body or the surface of the bionic body. The specific technical scheme is as follows:

A device for monitoring the movement state of the surface of a biological body or the surface of a bionic body, the preparation method of which comprises the following steps:

(1) Coat the high-viscosity polymer sol A on the surface of the living body or the inner surface of the bionic body, and then use infrared drying or low-temperature drying to cure it to obtain a sol that is close to the surface of the living body or the inner surface of the bionic body. Polymer cured film, infrared drying power is 10-50W, infrared drying time is 3-5min; low-temperature drying temperature is 40-60℃, low-temperature drying time is 5-10min;

(2) Use the liquid metal composite material B doped with modified graphene to prepare an electrical connector on the surface of the polymer cured film. The prepared electrical connector is semi-solid and can be evenly attached to the surface of the polymer cured film. There is no need to add an additional packaging process; the method for preparing an electrical connector from the modified graphene-doped liquid metal composite material B includes one or more of extrusion, electrohydrodynamic direct writing, and brush drawing;

(3) Mount motion state monitoring, energy supply, signal transmission, and control modules on the surface of the electrical connector to obtain a device for monitoring motion state on the surface of a biological body or the surface of a bionic body.

Described high molecular polymer sol comprises one or more in PVP hydrosol, PVP-PEG hydrosol, PVP-PLA hydrosol, PVP-PEG-PLA hydrosol, and the viscosity of described high molecular polymer sol is 1,000-4,000cp. The selected polymer sol material has good biocompatibility and low toxicity, and is rich in sources, so there is no need to worry about biosafety issues.

The bionic body is prepared by light-curing 3D printing acrylic composite resin, and the acrylic composite resin is composed of (1,4-butylene glycol) diacrylate, di(ethylene glycol) dimethacrylate, 1, It is made by mixing two or more resins of 4-butanediol dimethacrylate, 2-hydroxyethyl methacrylate and hydroxypropyl methacrylate. The selected biomimetic body material has good elasticity, toughness and stretchability after photocuring, so it can be used as a biomimetic material for the structure and function of organisms.

The preparation process of the liquid metal composite material B doped with modified graphene is as follows: the modified graphene, liquid metal and ester solvent are mixed according to the ratio of (0.001-0.03): (0.1-0.2): 1, and The mixture is mixed by ball milling and then vacuum dried. The ball milling speed is 100-300rpm, the ball milling time is 6-24h, the vacuum drying temperature is 120-180°C, and the vacuum drying time is 4-6h. Graphene is a kind of two-dimensional carbon nanomaterials with excellent electrical, thermal, mechanical and other physical and chemical properties, but its sheets have strong π-π interactions and high specific surface energy, resulting in its strong Chemical inertness tends to aggregate, which limits its excellent performance. By surface modification of graphene, on the one hand, the dispersion of graphene in ester solvents can be improved, which is conducive to the doping of graphene into liquid metal; on the other hand, the chemical bonds and molecules between graphene and liquid metal can be increased. Interaction force, and then obtain the modified graphene-doped liquid metal composite material that can be uniformly and stably attached to the surface of the polymer cured film.

The modified graphene includes one or more of reduced graphene oxide modified with halogen elements and graphene oxide modified with high active oxygen content.

The preparation process of the halogen element modified reduced graphene oxide is as follows: graphene oxide is mixed with a halogen modification solution with a concentration of 1 mol L ^-1 according to the mass ratio (0.01-0.25): 1, then heated, centrifuged, dried, heated The temperature is 60-90° C., the heating time is 6-12 hours, and the halogen modification solution contains one or more of AlI ₃ , AlBr ₃ , FeI ₂ , and FeBr ₂ .

The preparation process of the modified graphene oxide with high active oxygen content is as follows: put the graphene oxide into the oxidizing liquid mixed with equal volumes of _H2SO4 and _HNO3 , and heat under reflux for _8-18h under vacuum conditions, and the heating temperature is 70- 90°C, and then the graphene oxide after secondary oxidation was repeatedly washed with deionized water three times, the above steps were repeated three times, and centrifuged to obtain modified graphene oxide with high active oxygen content.

The liquid metal is a gallium-based liquid metal, the content of gallium metal is 65-95 parts by mass, the content of indium metal is 5-25 parts by mass, and the content of tin metal is 0-25 parts by mass. The melting point of the gallium-based liquid metal is 3-40°C.

The ester solvent includes one or more of methyl formate, ethyl formate, propyl formate, butyl formate, methyl acetate, ethyl acetate, propyl acetate, and butyl acetate.

The exercise state monitoring module includes one or more monitoring modules for measuring temperature, pressure, inorganic salts/sugars/enzymes/antibodies and other substances.

The beneficial effects of the present invention are: a device for monitoring the movement state of the surface of a living body or the surface of a bionic body is designed and prepared. The device is simple to prepare and has high safety. The modified graphene-doped liquid metal composite material has good carrier adaptability, and can prepare uniform and stable electrical connectors on the surface of the polymer cured film without additional Surface packaging treatment, wide application range. At the same time, the prepared electrical connector has high conductivity, flexibility, reliability and scope of application, which can meet the application requirements of monitoring the movement state of the surface of a biological body or the surface of a bionic body.

Description of drawings

Fig. 1 is the SEM figure of the liquid metal composite material doped with modified graphene used in the embodiment of the present invention 1;

Fig. 2 is the coherent interferogram of the electrical connector prepared on the surface of the PVP cured film by the liquid metal composite material doped with modified graphene in Example 1 of the present invention;

3 is a coherent interference diagram of an electrical connector prepared on the surface of a PVP cured film without using modified graphene-doped liquid metal in Comparative Example 2 of the present invention.

Detailed ways

The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention and the accompanying drawings. Obviously, the described content is only a part of the present invention, and those of ordinary skill in the art can make it without any creative work. All other obtained implementation modes belong to the protection scope of the present invention.

In order to solve the problems of poor uniformity of electrical connectors directly prepared by liquid metal, high selectivity to carriers, narrow application range, complicated process and poor safety of electrical connectors prepared by liquid metal in the prior art. The present invention designs and prepares a device for monitoring the movement state of the surface of a biological body or a bionic internal surface, and uses a high-viscosity high-molecular polymer sol to coat and dry the surface of a biological body or a bionic internal surface to obtain a solidified polymer Then use the modified graphene-doped liquid metal composite material to prepare electrical connectors on its surface, and mount the motion status monitoring, energy supply and control modules. The method is simple to prepare and has high safety. The modified graphene-doped liquid metal composite material has good carrier adaptability, and can prepare uniform and stable electrical connectors on the surface of the polymer cured film without additional Surface encapsulation treatment. At the same time, the prepared electrical connector has high conductivity and flexibility, which can meet the application requirements of monitoring the movement state of the surface of the biological body or the surface of the bionic body.

Example 1

The present invention provides a device for monitoring the movement state of the surface of a living body or the surface of a bionic body, and its preparation method comprises the following steps:

(1) Coat the PVP water sol on the surface of the organism or the inner surface of the bionic body, and then use infrared drying to cure it to obtain a cured polymer film that is close to the surface of the organism or the inner surface of the bionic body, and then dry it by infrared The power is 50W, and the infrared drying time is 5min;

(2) Use the modified graphene-doped liquid metal composite material B (as shown in Figure 1) to prepare an electrical connector (as shown in Figure 2) on the surface of the polymer cured film, and the prepared electrical connector is half Solid state, can evenly adhere to the surface of the polymer cured film; the electrical connector is prepared by extrusion, and the resistance of the obtained electrical connector is 2Ω;

(3) Mount motion state monitoring, energy supply, signal transmission, and control modules on the surface of the electrical connector to obtain a device for monitoring the motion state of the surface of the biological body or the surface of the bionic body.

The viscosity of PVP hydrosol is 4,000 cp.

The bionic body is prepared by light-curing 3D printing acrylic composite resin, and the acrylic composite resin is made by mixing (1,4-butylene glycol) diacrylate and di(ethylene glycol) dimethacrylate .

The preparation process of the modified graphene-doped liquid metal composite material B is as follows: the modified graphene, liquid metal and ester solvent are mixed according to the ratio of 0.03:0.1:1, and the mixture is mixed by ball milling and vacuum For drying, the ball milling speed is 100 rpm, the ball milling time is 6 hours, the vacuum drying temperature is 180° C., and the vacuum drying time is 6 hours.

The modified graphene is reduced graphene oxide modified with halogen elements.

The preparation process of the halogen element modified reduced graphene oxide is as follows: graphene oxide is mixed with a halogen modification solution with a concentration of 1 mol·L ^-1 according to the mass ratio of 0.01:1, then heated, centrifuged, and dried at a heating temperature of 60°C , the heating time is 12h, and the halogen modification solution contains AlI ₃ and AlBr ₃ .

The liquid metal is gallium-based liquid metal, the content of gallium metal is 70 parts by mass, the content of metal indium is 5 parts by mass, and the content of metal tin is 25 parts by mass.

The ester solvent is a mixture of methyl formate and methyl acetate in a mass ratio of 1:1.

The exercise state monitoring module includes one or more monitoring modules for measuring temperature, pressure, inorganic salts/sugars/enzymes/antibodies and other substances.

Example 2

The present invention provides a device for monitoring the movement state of the surface of a living body or the surface of a bionic body, and its preparation method comprises the following steps:

(1) Coating the PVP-PEG-PLA hydrosol on the surface of the organism or the inner surface of the bionic body, and then curing it by low-temperature drying to obtain a solidified polymer that is close to the surface of the organism or the inner surface of the bionic body Film; the low temperature drying temperature is 60°C, and the low temperature drying time is 10 minutes;

(2) Using liquid metal composite material B doped with modified graphene to prepare an electrical connector on the surface of the polymer cured film, the prepared electrical connector is semi-solid and can evenly adhere to the surface of the polymer cured film; The electrical connector is prepared by electrohydrodynamic direct writing, and the resistance of the obtained electrical connector is 1Ω;

(3) Mount motion state monitoring, energy supply, signal transmission, and control modules on the surface of the electrical connector to obtain a device for monitoring the motion state of the surface of the biological body or the surface of the bionic body.

The viscosity of the PVP-PEG-PLA hydrosol is 1,000 cp.

The bionic body is prepared by photocuring 3D printing acrylic composite resin, and the acrylic composite resin is composed of 1,4-butanediol dimethacrylate, 2-hydroxyethyl methacrylate, methacrylate hydroxyl Propyl esters are mixed.

The preparation process of the modified graphene-doped liquid metal composite material B is as follows: the modified graphene, liquid metal and ester solvent are mixed according to the ratio of 0.001:0.2:1, and the mixture is mixed by ball milling and vacuum For drying, the ball milling speed is 300 rpm, the ball milling time is 24 hours, the vacuum drying temperature is 120° C., and the vacuum drying time is 4 hours.

The modified graphene is graphene oxide modified with high active oxygen content.

The preparation process of the modified graphene oxide with high active oxygen content is as follows: put the graphene oxide into an oxidizing solution mixed with equal volumes of _H2SO4 and _HNO3 , heat under reflux for 18 hours under vacuum _conditions , and the heating temperature is 70 °C, and then After the secondary oxidized graphene oxide was repeatedly washed with deionized water three times, the above steps were repeated three times, and centrifuged to obtain modified graphene oxide with high active oxygen content.

The liquid metal is a gallium-based liquid metal, the content of gallium metal is 80 parts by mass, the content of metal indium is 10 parts by mass, and the content of metal tin is 10 parts by mass.

The ester solvent is a mixture of ethyl formate and ethyl acetate in a mass ratio of 1:3.

The exercise state monitoring module includes one or more monitoring modules for measuring temperature, pressure, inorganic salts/sugars/enzymes/antibodies and other substances.

Example 3

The present invention provides a device for monitoring the movement state of the surface of a living body or the surface of a bionic body, and its preparation method comprises the following steps:

(1) Coating PVP-PLA hydrosol on the surface of the organism or the inner surface of the bionic body, and then curing by infrared drying to obtain a cured polymer film that is close to the surface of the organism or the inner surface of the bionic body, The power of infrared drying is 10W, and the infrared drying time is 3min;

(2) Using liquid metal composite material B doped with modified graphene to prepare an electrical connector on the surface of the polymer cured film, the prepared electrical connector is semi-solid and can evenly adhere to the surface of the polymer cured film; The electrical connector is prepared by drawing with a brush, and the resistance of the obtained electrical connector is 2Ω;

(3) Mount motion state monitoring, energy supply, signal transmission, and control modules on the surface of the electrical connector to obtain a device for monitoring the motion state of the surface of the biological body or the surface of the bionic body.

The viscosity of the PVP-PLA hydrosol is 2,000 cp.

The bionic body is prepared by light-curing 3D printing acrylic composite resin, and the acrylic composite resin is mixed with di(ethylene glycol) dimethacrylate and 1,4-butanediol dimethacrylate .

The preparation process of the modified graphene-doped liquid metal composite material B is as follows: the modified graphene, liquid metal and ester solvent are mixed according to the ratio of 0.001:0.1:1, and the mixture is mixed by ball milling and vacuum For drying, the ball milling speed is 150 rpm, the ball milling time is 12 hours, the vacuum drying temperature is 140° C., and the vacuum drying time is 5 hours.

The modified graphene is reduced graphene oxide modified with halogen elements.

The preparation process of the halogen element modified reduced graphene oxide is as follows: graphene oxide is mixed with a halogen modification solution with a concentration of 1 mol·L ^-1 according to the mass ratio of 0.2:1, then heated, centrifuged, and dried at a heating temperature of 90°C , the heating time is 6h, and the halogen modification solution contains AlI ₃ and FeI ₂ .

The liquid metal is gallium-based liquid metal, the content of gallium metal is 95 parts by mass, and the content of metal indium is 5 parts by mass.

The ester solvent is a mixture of butyl formate and propyl acetate in a mass ratio of 1:10.

The exercise state monitoring module includes one or more monitoring modules for measuring temperature, pressure, inorganic salts/sugars/enzymes/antibodies and other substances.

Example 4

The present invention provides a device for monitoring the movement state of the surface of a living body or the surface of a bionic body, and its preparation method comprises the following steps:

(1) Coating the PVP-PEG hydrosol on the surface of the organism or the inner surface of the bionic body, and then curing it by low-temperature drying to obtain a cured polymer film that is close to the surface of the organism or the inner surface of the bionic body, The low-temperature drying temperature is 40°C, and the low-temperature drying time is 5 minutes;

(2) Using liquid metal composite material B doped with modified graphene to prepare an electrical connector on the surface of the polymer cured film, the prepared electrical connector is semi-solid and can evenly adhere to the surface of the polymer cured film; The electrical connector is prepared by electrohydrodynamic direct writing, and the resistance of the obtained electrical connector is 1.5Ω;

(3) Mount motion state monitoring, energy supply, signal transmission, and control modules on the surface of the electrical connector to obtain a device for monitoring the motion state of the surface of the biological body or the surface of the bionic body.

The viscosity of the PVP-PEG hydrosol is 3,000 cp.

The bionic body is prepared by light-curing 3D printing acrylic composite resin, and the acrylic composite resin is composed of (1,4-butanediol) diacrylate, 1,4-butanediol dimethacrylate, methyl A mixture of hydroxypropyl acrylate.

The preparation process of the modified graphene-doped liquid metal composite material B is as follows: the modified graphene, liquid metal and ester solvent are mixed according to the ratio of 0.03:0.2:1, and the mixture is mixed by ball milling and vacuum For drying, the ball milling speed is 220 rpm, the ball milling time is 18 hours, the vacuum drying temperature is 160° C., and the vacuum drying time is 4.5 hours.

The modified graphene is graphene oxide modified with high active oxygen content.

The preparation process of the modified graphene oxide with high active oxygen content is as follows: put the graphene oxide into an oxidizing solution mixed with equal volumes of _H2SO4 and _HNO3 , heat under reflux for 8 hours under vacuum _conditions , and the heating temperature is 90 ° C, and then After the secondary oxidized graphene oxide was repeatedly washed with deionized water three times, the above steps were repeated three times, and centrifuged to obtain modified graphene oxide with high active oxygen content.

The liquid metal is gallium-based liquid metal, the content of gallium metal is 65 parts by mass, and the content of metal indium is 25 parts by mass.

The ester solvent is a mixture of propyl formate and butyl acetate in a mass ratio of 1:5.

The exercise state monitoring module includes one or more monitoring modules for measuring temperature, pressure, inorganic salts/sugars/enzymes/antibodies and other substances.

Comparative example 1

Change the technical scheme of Example 1 to: instead of using high molecular polymer sol to coat the high molecular polymer cured film on the surface of the biological body or the surface of the bionic body, the liquid metal composite material doped with modified graphene is directly prepared in the On the surface of a biological body or the surface of a bionic body, a small amount of metal elements in liquid metal will immerse into the biological body through the body surface, causing certain safety hazards. Moreover, the modified graphene-doped liquid metal composite cannot directly prepare uniform and coherent high-quality electrical connectors on the surface of organisms, which will reduce the reliability of motion state monitoring.

Comparative example 2

Change the technical scheme of Example 1 to: do not use the electrical connector prepared by the liquid metal composite material doped with modified graphene, the resistance of the obtained electrical connector is 50Ω, and it cannot be prepared on the surface of the polymer cured film Uniform, continuous high-quality electrical connections. 3 is a coherent interference diagram of an electrical connector prepared on the surface of a PVP cured film without using modified graphene-doped liquid metal in Comparative Example 2 of the present invention.

It can be seen from the above that the device for monitoring the movement state of the surface of the living body or the surface of the bionic body prepared by the embodiment of the present invention has a simple preparation process and high safety, and the liquid metal composite material doped with modified graphene has good carrier adaptability , a uniform and stable electrical connection can be prepared on the surface of the polymer cured film, and no additional surface encapsulation treatment is required. At the same time, the prepared electrical connector has high conductivity and flexibility, which can meet the application requirements of monitoring the movement state of the surface of the biological body or the surface of the bionic body.

The above descriptions are only preferred implementation modes of the present invention, and are not intended to limit the protection scope of the present invention. Based on the embodiments of the present invention, those skilled in the art can make various changes accordingly, but any changes that are equivalent or similar to the present invention fall within the protection scope of the present invention.

Claims (8)

1. A device for monitoring the state of motion of the surface of a living body or the surface of a bionic body, characterized in that the preparation method of the device may further comprise the steps: (1) Coating the high molecular polymer sol A on the surface of the living body or the surface of the bionic body, drying and curing to obtain a cured film of the high molecular polymer that is close to the surface of the living body or the surface of the bionic body; the high molecular polymer sol Including one or more of PVP hydrosol, PVP-PEG hydrosol, PVP-PLA hydrosol, PVP-PEG-PLA hydrosol, the viscosity of the polymer sol is 1,000-4,000 cp; (2) Use the liquid metal composite material B doped with modified graphene to prepare an electrical connector on the surface of the cured polymer film. The prepared electrical connector is semi-solid and evenly attached to the surface of the cured polymer film; The method for preparing an electrical connector from the modified graphene-doped liquid metal composite material B includes one or more of extrusion, electrohydrodynamic direct writing, and brush drawing; the modified graphene-doped liquid metal The preparation process of the metal composite material B is as follows: the modified graphene, liquid metal and ester solvent are mixed according to the ratio of (0.001-0.03): (0.1-0.2): 1, and vacuum-dried. The temperature of the vacuum-dried is 120 -180 ℃, vacuum drying time is 4-6h; (3) Mount motion state monitoring, energy supply, signal transmission, and control modules on the surface of the electrical connector obtained in step (2), to obtain a device for monitoring the motion state of the surface of a biological body or the surface of a bionic body. 2. The device according to claim 1, characterized in that the bionic body described in step (1) is prepared by photocuring 3D printing acrylic composite resin, and the acrylic composite resin is made of diacrylic acid (1,4- Two of butanediol) ester, di(ethylene glycol) dimethacrylate, 1,4-butanediol dimethacrylate, 2-hydroxyethyl methacrylate, and hydroxypropyl methacrylate A mixture of one or more resins. 3. The device according to claim 1, wherein the modified graphene in step (2) includes one or both of halogen element-modified reduced graphene oxide and high active oxygen content modified graphene oxide. kind. 4. The device according to claim 3, characterized in that, the preparation process of the modified and reduced graphene oxide with halogen elements is as follows: the graphene oxide and the halogen modification solution with a concentration of 1 mol L ^-1 are mixed according to the mass ratio (0.01-0.25): 1 After mixing, heat, centrifuge, and dry. The heating temperature is 60-90 ℃, and the heating time is 6-12 h. The halogen modification solution contains AlI ₃ , AlBr ₃ , FeI ₂ , FeBr ₂ one or more of them. 5. The device according to claim 3, characterized in that, the preparation process of the modified graphene oxide with high active oxygen content is: putting graphene oxide into H ₂ SO ₄ and HNO ₃ equal volumes of mixed oxidation solution , reflux heating under vacuum conditions for 8-18h, the heating temperature is 70-90 ℃, then repeatedly rinse the oxidized graphene oxide with deionized water, repeat the above steps three times, and centrifuge to obtain modified graphite oxide with high active oxygen content alkene. 6. The device according to claim 1, characterized in that the liquid metal described in step (2) is gallium-based liquid metal, the content of gallium metal is 65-95 parts by mass, and the content of metal indium is 5-25 parts by mass , the content of metal tin is 0-25 parts by mass, and the melting point of the gallium-based liquid metal is 3-40°C. 7. device according to claim 1, is characterized in that, described ester solvent comprises methyl formate, ethyl formate, propyl formate, butyl formate, methyl acetate, ethyl acetate, propyl acetate, One or more of butyl acetate. 8. The device according to claim 1, characterized in that the exercise state monitoring module described in step (3) includes monitoring modules for measuring temperature, pressure, inorganic salts/sugars/enzymes/antibody substances one or several.

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