CN113729695B - A system and method for formulating an acoustic stimulation nerve regulation treatment plan - Google Patents
A system and method for formulating an acoustic stimulation nerve regulation treatment plan Download PDFInfo
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Abstract
本发明公开了一种声学刺激神经调控治疗方案的制定系统及其方法，包括：听觉和/或非听觉检测的信号输入和分析单元、声学刺激方案制定和存储单元、声学刺激方案实施单元。通过上述方式，本发明一种声学刺激神经调控治疗方案的制定系统及其方法，可以根据个性化检测结果，精准制定和实施难治性神经功能障碍这一大类慢病的生理部分和心理部分相结合的多疗程神经调控治疗康复方案，定期进行多次治疗效果的跟踪、客观评估和发展预测，定性定量地调控优化后续治疗方案的治疗效果，预测神经功能状态变化，制定和实施各种神经功能障碍慢病全周期管理方案。The present invention discloses a system and method for formulating an acoustic stimulation neuromodulation treatment plan, including: a signal input and analysis unit for auditory and/or non-auditory detection, an acoustic stimulation plan formulation and storage unit, and an acoustic stimulation plan implementation unit. Through the above-mentioned method, the system and method for formulating an acoustic stimulation neuromodulation treatment plan of the present invention can accurately formulate and implement a multi-course neuromodulation treatment rehabilitation plan that combines the physiological and psychological parts of a large category of chronic diseases such as refractory neurological dysfunction according to personalized test results, regularly track multiple treatment effects, objectively evaluate and predict development, qualitatively and quantitatively regulate and optimize the treatment effect of subsequent treatment plans, predict changes in neurological function status, and formulate and implement full-cycle management plans for various chronic diseases of neurological dysfunction.
Description
Technical Field
The invention relates to the field of diagnosis and treatment systems, in particular to a system and a method for formulating an acoustic stimulation nerve regulation and control treatment scheme.
Background
Neurological disorders including, but not limited to, tinnitus, sleep disorders, anxiety, depression, dizziness, autism, epilepsy, parkinson's disease (hyperactivity), alzheimer's disease (dementia), phonophobia, ear-stuffiness and ear-blocking, migraine and nerve fatigue, are related to the functional manifestations of central deep brain and multiple brain functional areas and cerebral cortex and the cross-influence of dynamic neural networks to varying degrees, are manifested in two major parts of objective physiology and subjective psychological emotion, and various neurological disorders manifest specific differences in focus, pathogenesis, cross-influence of brain functional areas, and the like. Neurological dysfunction diseases are diseases with highest incidence rate and highest medical insurance burden in the aged society, and have unclear pathogenesis and lack of special drugs and means. Almost every elderly person suffers from at least one more neurological dysfunction disease. The nerve dysfunction is essentially the functional disorder of the nervous system transmission and the electrophysiological signal filtering mechanism, belongs to the biophysical category, and is more direct and suitable for a physical intervention treatment method. Neuromodulation therapy is active physical intervention therapy, the core of which is what and how to modulate to achieve the best effect of quantitative therapy.
At present, the traditional diagnosis and treatment of the neurological dysfunction disease has a plurality of defects or weaknesses, such as incapability of combining objective physiology and subjective psychology to perform accurate treatment and comprehensive treatment, incapability of implementing differentiated, adjustable and controllable nerve regulation treatment aiming at different brain functional areas and brain cortex, low technical service efficiency, difficulty in standardization, inconvenience in large-scale popularization and the like. Therefore, the acoustic stimulation noninvasive nerve regulation and control accurate treatment system regulation and control method based on the nerve electrophysiological principle, which is universally applicable to the full period management of the multi-treatment course treatment and rehabilitation of various nerve dysfunction chronic diseases, is convenient to implement in clinical operation, and is established on the basis of personalized brain activity fluctuation signals expressed by various subjective and/or objective hearing and/or non-hearing nerve activity detection equipment, the breakthrough from hearing detection to non-hearing detection is realized, the physiological and psychological interaction circulation influence of nerve dysfunction is reflected more comprehensively, the commonality of various nerve dysfunction diseases is considered, and the enough flexibility is not lost, so that the individual characteristics of various refractory nerve dysfunction diseases, the different clinical characteristics of two ear sides and the accurate treatment requirements are taken into consideration.
Disclosure of Invention
In order to solve the technical problems, the invention adopts a technical scheme that:
The system comprises a nerve dysfunction detection signal input interface unit, a signal preprocessing unit, an acoustic stimulation scheme making and storing unit and an acoustic stimulation scheme implementation unit, wherein a fluctuation signal which is detected by human auditory sense and/or non-auditory sense and expresses brain activities in various different physical quantities is input into the signal preprocessing unit through a brain-computer interface and the signal input interface unit so as to carry out parting and conversion analysis on nerve electrophysiological signals, the acoustic stimulation scheme making and storing unit respectively and individually makes acoustic stimulation treatment schemes corresponding to two ear sides according to processing information output by the signal preprocessing unit, so that comprehensive physical intervention acoustic stimulation noninvasive nerve regulation accurate treatment combining physiology and psychology is carried out, the acoustic stimulation scheme implementation unit inputs acoustic stimulation signals into an auditory canal and converts the acoustic stimulation signals into stimulation electrical signals through a cochlea, enters the brain center through an auditory pathway, so that the electric stimulation nerve regulation is carried out on the brain nerve system, the nerve regulation accurate treatment on various refractory nerve dysfunction diseases is realized, and the full period management of the nerve chronic disease multiple personalized treatment is carried out.
A method for preparing acoustic stimulation nerve regulation and control treatment scheme includes inputting human auditory psychoacoustic detection signal and human non-auditory nerve biofeedback detection signal through brain-computer interface, carrying out signal typing and conversion analysis on two auditory and/or non-auditory detection fluctuation signals expressed by different physical quantities respectively to decompose the signals into multiple signal components suitable for signal modulation treatment on different auditory sides, extracting signal characteristic parameters, inputting the signal components and characteristic parameters on each auditory side into multiple single signal processing channels respectively, carrying out acoustic signal modulation treatment on each signal processing channel by adopting multi-channel multi-mode acoustic modulation signal processing algorithm, superposing and/or compounding acoustic modulation signals output by each channel, combining diagnosis information of nerve dysfunction diseases to carry out signal synthesis and optimization of signal modulation parameters, outputting or compounding into one or multiple multi-channel acoustic stimulation non-nerve regulation and control treatment scheme for different types of nerve dysfunction slow diseases, carrying out acoustic stimulation non-invasive nerve regulation and control scheme by means of left and/or right side and/or respectively carrying out acoustic signal modulation treatment on each channel, carrying out acoustic modulation treatment on acoustic modulation signal and acoustic modulation signal by adopting multiple channels simultaneously, carrying out acoustic modulation treatment on the acoustic modulation treatment channel information, carrying out acoustic stimulation and acoustic regulation and control on the nerve dysfunction disease, and the acoustic stimulation treatment scheme comprises full-acoustic stimulation, and acoustic regulation and control treatment, and acoustic regulation and control of nerve dysfunction diseases, and acoustic regulation and control treatment, and acoustic regulation treatment of the acoustic regulation and control parameters are realized.
In a preferred embodiment of the present invention, when obtaining auditory detection signals of two sides of a human body, subjective detection signals and/or objective detection signals of auditory nerves of each side of the human body are respectively input into a signal preprocessing unit through a brain-computer interface for signal typing and conversion analysis, wherein the subjective detection comprises but not limited to hearing threshold under living noise environment, ultra-high frequency pure-tone hearing detection extending from 1Hz to 8KHz to more than 10KHz in a conventional hearing frequency range, the semi-objective semi-subjective detection comprises but not limited to multi-channel multi-mode psychoacoustic earring matching or reduction detection for complex tinnitus sound reduction, signal components of each channel are respectively expressed in simple sound elements including but not limited to pure tone, pulse, noise, auditory multi-frequency stem evoked potential ABR detection and/or auditory multi-frequency steady evoked potential ASSR detection for detecting cognitive behavioral psychological activity and psychological response function, and endogenous event related evoked potential P300 detection.
In a preferred embodiment of the invention, when a human non-auditory detection signal is acquired, the non-auditory detection signal obtained by non-auditory objective detection is input into a signal preprocessing unit through a brain-computer interface for signal typing and conversion analysis, wherein the human non-auditory detection signal comprises but is not limited to detection signals representing electrophysiological activity of each brain functional area, interaction of a plurality of brain functional areas, dynamic change of brain electrical signals, neural network attribute and energy change or difference, and the non-auditory objective detection method comprises but is not limited to EEG signal detection and event-related evoked potential ERP detection based on EEG.
In a preferred embodiment of the invention, the steps of signal parting and conversion analysis on the detection signals of human auditory sense and/or non-auditory sense comprise selecting auditory sense signal waveforms and non-auditory sense signal waveforms, obtaining fluctuation signals containing amplitude and frequency parameters reflecting different physical quantities of brain region electrophysiological activity and multi-brain region interaction through mathematical transformation and analysis processing of the signal waveforms, decomposing the complex wave signals into a plurality of signal components located in different frequency bands or different wave characteristics when the complex wave signals have a plurality of frequency points or wave crest and trough sections, and respectively analyzing the signal components and extracting signal characteristic parameters, wherein the mathematical transformation and analysis processing of the signal waveforms comprises but is not limited to fast Fourier transformation FFT analysis of time domain and frequency domain of the signals, wavelet transformation WT time-frequency analysis, power spectrum density analysis of brain wave signals and neural network attribute analysis, and the signal characteristic parameters comprise but are not limited to signal waveforms, amplitude A m and frequency f m corresponding to each signal component.
In a preferred embodiment of the present invention, in the typing and conversion analysis of subjective and/or objective detection signals reflecting physiological and psychological parts of the neurological disorder disease, further typing analysis is performed on complex waveforms expressed by dynamic changes of neurophysiologic activities and cognitive psychological activities respectively and expressed by interaction comprehensively, wherein the further typing analysis comprises, but is not limited to, waveform mutation analysis, notch point analysis of signal curve mutation, and specific division analysis, so as to further adjust and optimize characteristic parameters of signal components.
In a preferred embodiment of the present invention, the characteristic parameters of the signal components are further adjusted and optimized according to the typing and conversion analysis results of the human neuro-electrophysiological detection signals, in combination with clinical subjective diagnosis information including, but not limited to, clinical characteristic information about sleep, anxiety, depression, and acoustic sensitivity and psycho-psychological subjective scale evaluation information thereof.
In a preferred embodiment of the invention, when signal components of each signal channel are respectively subjected to signal modulation processing, a modulation wave trigonometric function is firstly selected and a carrier trigonometric function is set, the signal components are subjected to trigonometric function modulation processing, the trigonometric function modulation processing comprises but not limited to sine wave amplitude modulation SAM, sine wave frequency modulation SFM and sine wave amplitude frequency mixing modulation SAFM, then single-side or double-side modulation sound signals of each channel are output to be synthesized by a subsequent multi-channel multi-mode acoustic stimulation scheme, wherein parameters of the modulation wave trigonometric function come from characteristic parameter values reflecting nerve electric activity signal components in each channel, the characteristic parameter values of the signal components comprise but not limited to a main frequency point or a frequency division frequency value f m and a preset hearing threshold amplitude variation value A m not exceeding 20dB, and amplitude value A c and frequency value f c of the carrier trigonometric function are obtained according to an amplitude modulation coefficient and a frequency modulation coefficient preset on the basis of a modulation wave as a proportion, and the amplitude modulation coefficient is less than 1.0, and the frequency modulation coefficient range ranges are 0.1% -10%.
In a preferred embodiment of the present invention, when a personalized acoustic stimulation treatment scheme is prepared, modulated acoustic signals output by each channel are directly or according to preset contribution weights of each channel, superimposed and/or compounded to form a multi-channel multi-mode compound modulated acoustic signal; respectively carrying out background sound superposition and signal waveform regulation and control treatment on the composite modulation acoustic signals of the two ear sides, superposing the treated regulation and control amplitude with the hearing threshold value of the main frequency point corresponding to the wave signal detected or converted by the corresponding ear side of the human body, and regulating the volume by balancing the left ear and the right ear so as to obtain a personalized multi-channel multi-mode acoustic stimulation noninvasive nerve regulation and control treatment scheme corresponding to the two ear sides, and generating an acoustic stimulation signal which can be perceived and received by people, has amplitude and frequency changed and can transmit enough energy; the method comprises the steps of playing a formulated individualized acoustic stimulation signal of a single ear and/or a double ear through an earphone, converting the individualized acoustic stimulation signal into an electrical stimulation signal through a cochlea, entering a brain center through an auditory pathway, actively carrying out parameter-adjustable controllable electrical stimulation on a nervous system to realize nerve regulation and control accurate treatment, gradually recovering a normal discharging function of neurons through multi-course acoustic stimulation accurate treatment, desynchronizing a clutter signal in the nervous system, remodelling the nervous system so as to reduce or remove nerve dysfunction perception and gradually recover the health state of the nervous system function, wherein the individualized acoustic stimulation signal comprises but not limited to a stimulation rate, a stimulation amplitude, a stimulation waveform or a melody, and the signal waveform regulation comprises but not limited to triangular wave regulation, rectangular wave regulation, pulse wave regulation, sawtooth wave regulation, trough extension regulation, change period regulation and waveform notch knocking regulation.
In a preferred embodiment of the present invention, when performing full-period management of multi-course treatment rehabilitation applicable to multiple kinds of nerve dysfunction chronic diseases, by acquiring human auditory and/or non-auditory detection signals in real time and/or at regular time, repeatedly performing iterative loop processes of the single-ear and/or double-ear acoustic stimulation nerve regulation treatment scheme, starting iteration from actual initial detection and analysis, so as to adjust and optimize corresponding parameters of the acoustic stimulation treatment scheme, thereby performing adjustment, update and optimization of the diagnosis and treatment scheme to achieve the optimal effect of nerve regulation accurate treatment, wherein the parameters of the acoustic stimulation treatment scheme include, but are not limited to, amplitude and frequency of modulation signals, contribution weights of relevant channels or frequency bands in multi-channel signal superposition synthesis, daily treatment frequency and treatment course.
The invention has the beneficial effects that a multi-course nerve regulation and control accurate treatment rehabilitation scheme combining the physiological part and the psychological part of the chronic disease of the refractory nerve dysfunction can be formulated and implemented, the tracking, objective evaluation and development prediction of multiple treatment effects are regularly carried out, the treatment effect of a follow-up treatment scheme is qualitatively and quantitatively regulated and optimized, the change of the nerve function state is predicted, and the full-period management scheme of the chronic disease of the nerve dysfunction is formulated and implemented.
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For a clearer description of the technical solutions of the embodiments of the present invention, the drawings that are needed in the description of the embodiments will be briefly introduced below, it being obvious that the drawings in the description below are only some embodiments of the present invention, and that other drawings can be obtained according to these drawings without inventive effort for a person skilled in the art, wherein:
FIG. 1 is a schematic flow diagram of a system and method for formulating an acoustic stimulation neuromodulation therapy scheme according to the present invention;
FIG. 2 is a schematic diagram of auditory physiological pathways and cognitive psychological pathways of the cranial nerve system in a system and method for formulating an acoustic stimulation neuromodulation therapy regimen in accordance with the present invention;
FIG. 3 is a schematic illustration of the "physiological+psychological" cross-action of the central nervous system of the brain in a system and method for formulating an acoustic stimulation neuromodulation therapy regimen in accordance with the present invention;
FIG. 4 is a schematic diagram of signal modulation class division in a system and method for formulating an acoustic stimulation neuromodulation therapy regimen in accordance with the present invention;
FIG. 5 is a schematic diagram of signal modulation waveforms in a system and method for formulating an acoustically stimulated neuromodulation treatment regimen in accordance with the present invention;
FIG. 6 is a diagram of a pure tone hearing waveform of a system and method for formulating an acoustic stimulation neuromodulation therapy regimen in accordance with the present invention;
FIG. 7 is a schematic representation of brain stem auditory evoked potential ABR waveforms in a system and method for formulating an acoustically stimulated neuromodulation treatment regimen in accordance with the present invention;
FIG. 8 is a schematic diagram of event-related evoked potential ERP waveforms in a system and method for formulating an acoustic stimulation neuromodulation therapy regimen in accordance with the present invention;
FIG. 9 is a schematic diagram of EEG power spectral density waveforms in a system and method for formulating an acoustically stimulated neuromodulation therapy regimen in accordance with the present invention;
FIG. 10 is a schematic diagram of an exemplary acoustic stimulation acoustic signal wave (loudness versus time) of a system and method for formulating an acoustic stimulation neuromodulation therapy regimen in accordance with the present invention;
FIG. 11 is a schematic diagram of another exemplary acoustic stimulation acoustic signal wave (loudness versus time) of a system and method for formulating an acoustic stimulation neuromodulation therapy regimen in accordance with the present invention;
FIG. 12 is a schematic diagram of a system for formulating an acoustically stimulated neuromodulation therapy regimen in accordance with the present invention;
Fig. 13 is a schematic diagram of the internal architecture of a system for formulating an acoustically stimulated neuromodulation therapy regimen in accordance with the present invention.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1-13, an embodiment of the present invention includes:
A system for preparing acoustic stimulation nerve regulation treatment scheme is suitable for preparing universal multichannel multimode acoustic stimulation noninvasive nerve regulation treatment scheme of various refractory nerve dysfunction diseases, and comprises a nerve dysfunction detection signal input interface unit for receiving auditory and/or non-auditory detection signals, a signal preprocessing unit, an acoustic stimulation scheme preparing and storing unit and an acoustic stimulation scheme implementation unit.
Among them, various neurological disorders include, but are not limited to, tinnitus, deafness, sleep disorders, anxiety, depression, dizziness, meniere, sudden deafness, ear-stuffiness and plug, migraine, nerve fatigue, epilepsy, parkinson, hyperactivity disorder, autism, bad hobbies, alzheimer's and dementia.
With respect to the human auditory detection signals, subjective detection signals and/or objective detection signals of human auditory nerves are input into a signal preprocessing unit through a brain-computer interface so as to perform signal typing and conversion analysis on the subjective detection signals and/or objective detection signals.
The corresponding auditory subjective detection of each ear side comprises, but is not limited to, a hearing threshold value under a living noise environment, an ultrahigh frequency pure-tone hearing detection which is expanded to be more than 10KHz from a conventional hearing frequency range of 1Hz to 8KHz, the corresponding auditory semi-objective semi-subjective detection of each ear side comprises, but is not limited to, a multi-channel multi-mode psychoacoustic tinnitus matching or restoring detection for the restoration of the tinnitus, a partial signal of each channel is expressed by a simple sound element, a sound intensity, a frequency range and/or a melody, namely, the simple sound element expressing complex tinnitus is obtained through the multi-channel simple sound element, only the simple sound element can be subjected to signal modulation processing expressed by a mathematical formula, wherein the simple sound element comprises, but is not limited to, pure tone, pulse and noise, and the corresponding auditory semi-objective detection of each ear side comprises, but is not limited to, an auditory brainstem evoked potential ABR detection for the change of auditory brainstem potential waves and/or an auditory multi-frequency evoked potential steady state psychological evoked potential ASSR detection for detecting the cognitive behavioral activity and psychological response function, and an event related evoked event related endogenous event detection 300 ERP.
Regarding the human non-auditory detection signal, the neural electric activity signal obtained by the non-auditory objective detection is input into the input signal preprocessing unit through the brain-computer interface for signal typing and conversion analysis. Human non-auditory detection signals include, but are not limited to, detection signals that characterize electrophysiological activity of various brain function regions, interactions of multiple brain function regions, dynamic changes in brain electrical signals, neural network properties, and energy changes or differences, and the like. Human non-auditory detection includes, but is not limited to, electroencephalogram EEG signal detection, event-related evoked potential ERP detection based on electroencephalogram EEG.
A method for formulating an acoustically stimulated neuromodulation therapy regimen, comprising the steps of:
(1) Aiming at each nerve dysfunction chronic disease characteristic, which shows interaction of physiological parts and psychological parts of nerve dysfunction diseases, whether a human auditory psychoacoustic detection signal or a human non-auditory nerve biofeedback signal, respectively carrying out signal typing and conversion analysis on auditory and/or non-auditory detection fluctuation signals expressed in different physical quantities so as to decompose the signals into a plurality of signal components suitable for signal modulation processing, and extracting signal characteristic parameters.
(1.1) The step of typing and conversion analysis of human auditory and/or non-auditory detection signals comprises:
(1.1.1) selecting the auditory sense signal waveform and the non-auditory sense signal waveform.
(1.1.2) Obtaining related fluctuation signals which reflect different physical quantities of the brain region electrophysiological activity and the interaction of multiple brain regions and contain parameters such as amplitude, frequency and the like through mathematical transformation and analysis processing of signal waves. Mathematical transformation and analysis processing of the signal wave includes, but is not limited to, fast fourier transform FFT analysis of the time and frequency domains of the signal, wavelet transform WT time-frequency analysis, power spectral density analysis of the brain wave signal, and neural network attribute analysis.
(1.1.3) Decomposing the multi-modal composite electrophysiological activity signal with multiple frequency points or multiple peak-valley segments into multiple simple signal components in different frequency bands or with different characteristics, wherein the different signal components correspond to multiple signal processing or algorithm channels, analyzing the electrical activity signal components of the nerve dysfunction in each signal channel and extracting signal characteristic parameters, wherein the signal characteristic parameters comprise, but are not limited to, signal waveforms, wave amplitudes A m and frequencies f m corresponding to each channel.
(1.1.4) In the analysis of the input signals reflecting various neural activities, further classifying the complex waveforms expressed by the dynamic changes of the neurophysiologic activities and the cognitive psychological activities and the complex waveforms expressed by the interaction respectively, thereby further adjusting and optimizing the characteristic parameters of the signal components in the step (1.1.3). Further typing assays include, but are not limited to, waveform mutation assays, notch point assays for signal curve mutations, specificity partitioning assays.
(2) The signal components and the signal characteristic parameters are input into a plurality of corresponding single signal processing channels, and a multi-channel multi-mode acoustic modulation signal processing algorithm is adopted to perform acoustic signal modulation processing on each signal processing channel. Among them, the multi-channel multi-mode acoustic modulation signal processing algorithm includes, but is not limited to, the signal modulation algorithm of amplitude modulation SAM, frequency modulation SFM, and amplitude modulation frequency modulation hybrid SAFM using trigonometric functions.
In implementation, according to the characteristic parameters of the multi-channel multi-mode nerve dysfunction electrical signal in the step (1.1.4) (including but not limited to the signal waveform, the amplitude A m and the frequency f m corresponding to each channel), and combining the nerve dysfunction typing analysis in the step (1.1.3), obtaining corresponding multi-channel multi-mode acoustic modulation signals through a multi-channel multi-mode acoustic modulation signal processing algorithm.
Signal components of each signal channel are subjected to signal modulation processing respectively:
And (2.1) firstly selecting a modulation wave trigonometric function and setting a carrier trigonometric function, wherein the parameters of the modulation wave trigonometric function are from characteristic parameter values reflecting nerve electric activity signal components in each channel, including but not limited to a main frequency point or a frequency division frequency value f m and a set hearing threshold amplitude variation value A m not exceeding 20dB, the amplitude value A c and the frequency value f c of the carrier trigonometric function are obtained according to an amplitude modulation coefficient (less than 1) and a frequency modulation coefficient range (0.1% -10%) preset on the basis of the modulation wave, and the signal trigonometric function modulation includes but is not limited to sine wave amplitude modulation SAM, sine wave frequency modulation SFM and sine wave amplitude frequency mixed modulation SAFM.
In one embodiment, the sine wave amplitude modulation (Sinusoidal Amplitude Modulation, SAM) details include:
Signal characteristic parameters are obtained from the nerve detection signal processing as the amplitude a m and frequency f m of the input signal to be modulated.
Setting a sine wave mathematical expression of the carrier signal D (t):
D(t) = Ac*sin(2πfct)。
Where a c is the carrier amplitude, f c is the carrier frequency, and t is time.
A c = m*Am, m is the amplitude modulation factor, 0.ltoreq.m.ltoreq.1, f c can be set according to the modulation requirement or according to a certain proportion of f m (for example: 0.1% -10%).
Mathematical representation of the sine wave of the modulated amplitude a (t) over time:
A(t) = [1 + m*sin(2πfmt)]
Where f m is the modulation frequency.
The sine wave mathematical expression after signal amplitude modulation is obtained as follows:
D(t) = (Ac*A(t))*sin(2πfct)
= Ac*[1 + m*sin(2πfmt)]*sin(2πfct)
Where only time t is a trigonometric function variable.
Unlike available technology, the present application has the characteristic parameters A m and f m of the nerve signal component obtained through clinical auditory and/or non-auditory brain activity detecting signal parting and converting analysis and signal decomposing as input, the setting method of carrier function parameters A c and f c, and the simple signal modulation in each channel, output and synthesis compounding to obtain the synthesized acoustic modulation signal reflecting the complicated brain activity signal, input into auditory canal and converted into stimulating electric signal via cochlea, enter into brain center via auditory path to electrically stimulate nerve regulation and control the brain nerve system, and this makes it possible to treat nerve regulation and control accurate for various refractory nerve dysfunction diseases.
(2.2) Outputting a single-side or double-side modulated acoustic signal of each channel to perform multi-channel multi-mode acoustic stimulation scheme synthesis.
(3) And superposing and/or compounding the modulated acoustic signals output by the channels, and further carrying out signal synthesis and optimization of signal modulation parameters by combining diagnostic information so as to formulate personalized acoustic stimulation treatment schemes aiming at different types of nerve dysfunction chronic diseases. Diagnostic information includes, but is not limited to, hearing threshold information, sleep information, anxiety information, depression actual condition information, and various clinical subjective scale assessment information reflecting psychology.
And (3.1) simply superposing and/or compositing the modulated acoustic signals output by the channels, or superposing and/or compositing the modulated acoustic signals output by the channels according to preset contribution weights of the channels to form a multi-channel multi-mode composite modulated acoustic signal.
And (3.2) further performing background sound superposition and signal waveform regulation and control on the multichannel multimode composite modulation acoustic signals corresponding to each ear side through nerve electric activity signal typing analysis and clinical diagnosis information combination, and superposing the background sound superposition and signal waveform regulation and control with the hearing threshold of the corresponding main frequency point detected in the step (1), so as to obtain a personalized multichannel multimode acoustic stimulation noninvasive nerve regulation and control accurate treatment scheme of single ear and/or double ears. The signal waveform regulation comprises, but is not limited to, triangular wave regulation, rectangular wave regulation, pulse wave regulation, sawtooth wave regulation, trough extension regulation, change period regulation and waveform notch knocking regulation.
(4) The formulated personalized acoustic stimulation treatment scheme is input into auditory meatus (auditory nerve channel) at corresponding auditory side through earphone, and is converted into electric stimulation signal through cochlea, and the electric stimulation signal is used for carrying out parameter-adjustable controllable stimulation on the nervous system, so as to promote the nervous system to recover to normal state, and simultaneously carry out 'physiological+psychological' comprehensive physical intervention noninvasive nerve regulation acoustic stimulation treatment on different kinds of refractory nerve dysfunction chronic diseases, thus realizing the multi-treatment course treatment and rehabilitation full-period management of the nerve chronic diseases.
As shown in fig. 2, the solid line box is an objective auditory physiological pathway and the dotted line box is a subjective cognitive psychological pathway. When the physiological and psychological comprehensive physical intervention noninvasive nerve regulation treatment is carried out on a plurality of patients with nerve dysfunction, a formulated personalized acoustic stimulation treatment scheme with nerve regulation function is played through an earphone, the personalized acoustic stimulation treatment scheme is converted into electric stimulation signals through a cochlea, the electric stimulation signals enter a central nerve thalamus and a sea horse area to be respectively subjected to further signal classification processing, the electric stimulation signals are classified and transmitted into corresponding cerebral cortex according to human brain electrical signals, a large number of neurons passing through a nervous system are activated by the electric stimulation signals, the electric stimulation signals are further amplified and pushed to be transmitted, the normal discharge function of the neurons is gradually recovered through the multi-course acoustic stimulation, the clutter signals in the nervous system are desynchronized, and the nervous system is remodelled, so that the nerve dysfunction perception is reduced or removed, and the health state of the nervous system is gradually recovered.
In order to achieve the effect of acoustic stimulation to regulate and control the nerve system and neurons in different brain functional areas, the energy, the amplitude modulation and/or the change rate of the frequency modulation and the duration of the continuous stimulation required by each stimulation are comprehensively considered, so that different nerve regulation and control treatment schemes are formed, and the aim of treating different nerve dysfunction chronic diseases is fulfilled.
When the multi-treatment-period rehabilitation full-period management suitable for various nerve dysfunction chronic diseases is realized, the relevant nerve dysfunction detection of the step (1) can be carried out according to the condition change and/or the timing of a patient, the treatment effect and the condition change are evaluated, the iterative loop processes of the steps (1) - (4) are repeated in time, iteration is carried out from the initial detection and analysis which possibly inaccurately reflect the actual condition of the patient, relevant parameters of the corresponding acoustic stimulation treatment scheme are gradually adjusted and optimized, the parameters comprise but are not limited to the amplitude and the frequency of a modulation signal, the contribution weight of relevant channels or frequency bands in the multi-channel signal superposition synthesis, the daily treatment frequency and the multi-treatment-period treatment, the diagnosis and treatment scheme is adjusted, updated and optimized regularly, the treatment effect is improved until the patient feels that the condition is improved and/or the electrophysiological signal detection reflects the obvious change, and the satisfaction degree of the patient is improved.
The basic principle of the method is that the method is about the collection, processing and application of nerve electric signals suitable for various refractory nerve dysfunction chronic diseases, and can be further upgraded and expanded to be applied to the fields of digital medical treatment and cloud service based on the characteristic that electric signals are convenient for network transmission, and the method covers more areas and people, patients, doctors and specialists in various levels. In addition, steps (1) - (4) can be applied as a general neuromodulation technology approach and method to physical examination, efficacy assessment and health management of a variety of neurological dysfunctional chronic conditions.
The system and the method for formulating the acoustic stimulation nerve regulation treatment scheme have the beneficial effects that a multi-treatment-period nerve regulation treatment rehabilitation scheme combining the physiological part and the psychological part of the chronic disease of the refractory nerve dysfunction can be formulated and implemented, the tracking, objective evaluation and development prediction of multiple treatment effects are regularly carried out, the treatment effect of a subsequent treatment scheme is qualitatively and quantitatively regulated and optimized, the change of the nerve function state is predicted, and the whole-period management scheme of the chronic disease of the nerve dysfunction is formulated and implemented.
The foregoing description is only illustrative of the present invention and is not intended to limit the scope of the invention, and all equivalent structures or equivalent processes or direct or indirect application in other related arts are included in the scope of the present invention.
Claims (8)
1. A device for formulating an acoustically stimulated neuromodulation therapy regimen, comprising the steps of:
Inputting human auditory psychoacoustic detection signals and human non-auditory nerve biofeedback detection signals through a brain-computer interface, respectively carrying out signal typing and conversion analysis on auditory and non-auditory detection fluctuation signals which are expressed by different physical quantities and are different on two ear sides so as to decompose the signals into a plurality of signal components which are suitable for signal modulation processing and are on different ear sides, and extracting signal characteristic parameters; the method comprises respectively inputting signal components and characteristic parameters of each ear side into multiple single signal processing channels, adopting multi-channel multi-mode acoustic modulation signal processing algorithm, performing acoustic signal modulation processing on each signal processing channel, superposing and/or compounding acoustic modulation signals output by each channel, combining diagnosis information of nerve dysfunction diseases, optimizing signal synthesis and signal modulation parameters, outputting or compounding into one or more multi-channel multi-mode individualized ear side acoustic stimulation noninvasive nerve regulation and control treatment schemes, performing individualized non-invasive nerve regulation and control treatment schemes by respectively inputting acoustic nerve channels through left and/or right ear side ear computers, performing comprehensive physical intervention non-invasive nerve regulation acoustic stimulation accurate treatment by combining physiology and psychology, realizing multi-treatment course individualized treatment rehabilitation full period management of the nerve chronic diseases, repeatedly executing acoustic nerve regulation and control acoustic treatment parameters of single ear and/or double ears by acquiring acoustic detection signals in real time and/or timing when performing multi-treatment course treatment rehabilitation full period management suitable for multiple nerve dysfunction chronic diseases, repeating the corresponding acoustic nerve regulation and control treatment schemes and optimization of acoustic stimulation and control schemes, thereby adjusting, updating and optimizing the diagnosis and treatment scheme to achieve the optimal effect of the precise treatment of the nerve regulation and control, wherein the diagnosis information of the nerve dysfunction disease comprises but is not limited to hearing threshold information, sleep information, anxiety information and depression information;
Objective detection includes event related evoked potential ERP detection and endogenous event related evoked potential P300 detection for detecting cognitive behavioral psychological activities and psychological response functions;
When a human non-auditory detection signal is acquired, inputting the non-auditory detection signal obtained by non-auditory objective detection into a signal preprocessing unit through a brain-computer interface for signal typing and conversion analysis, wherein the human non-auditory detection signal comprises but is not limited to detection signals representing electrophysiological activity of each brain functional area, interaction of a plurality of brain functional areas, dynamic change of brain electrical signals, neural network attribute and energy change or difference, and the non-auditory objective detection method comprises but is not limited to EEG signal detection and event-related evoked potential ERP detection based on EEG;
The method comprises the steps of selecting auditory detection signal waveforms and non-auditory detection signal waveforms, obtaining fluctuation signals containing amplitude and frequency parameters reflecting different physical quantities of brain region electrophysiological activity and multi-brain region interaction through mathematical transformation and analysis processing of the signal waveforms, decomposing a complex wave signal into a plurality of signal components positioned in different frequency bands or with different wave characteristics when the complex wave signal has a plurality of frequency points or wave crest and wave trough sections, and analyzing the signal components and extracting signal characteristic parameters;
When the signal components of each signal channel are respectively subjected to signal modulation processing, a modulation wave trigonometric function is selected and a carrier trigonometric function is set, the signal components are subjected to trigonometric function modulation processing, the trigonometric function modulation processing comprises but is not limited to sinusoidal amplitude modulation SAM, sinusoidal frequency modulation SFM and sinusoidal amplitude frequency mixing modulation SAFM, then single-side or double-side modulation sound signals of each channel are output to be synthesized by a subsequent multi-channel multi-mode acoustic stimulation scheme, wherein parameters of the modulation wave trigonometric function come from characteristic parameter values reflecting nerve electric activity signal components in each channel, the characteristic parameter values of the signal components comprise but are not limited to a main frequency point or a frequency division frequency value f m and a set hearing threshold amplitude variation value A m which is not more than 20dB, and an amplitude value A c and a frequency value f c of the carrier trigonometric function are obtained according to an amplitude modulation coefficient and a frequency modulation coefficient preset on the basis of a modulation wave as a proportion, and the amplitude modulation coefficient is smaller than 1.0, and the frequency modulation coefficient range ranges from 0.1% -10%;
When the personalized acoustic stimulation treatment scheme is formulated, the modulated acoustic signals output by each channel are directly or according to the preset contribution weight of each channel to be overlapped and/or compounded to form multi-channel multi-mode compound modulated acoustic signals, the compound modulated acoustic signals at the two ear sides are respectively further subjected to background sound overlapping and signal waveform regulating and controlling treatment, the treated regulating and controlling amplitude is overlapped with the hearing threshold value of the main frequency point corresponding to the wave signal detected or converted at the corresponding ear side of the human body, and after the volume is regulated by the balance of the left ear and the right ear, the personalized multi-channel multi-mode acoustic stimulation noninvasive nerve regulating and controlling treatment scheme corresponding to the two ear sides is obtained, so that the acoustic stimulation signals which can be perceived and received by people and change in amplitude and frequency and can transmit enough energy can be generated.
2. The device for formulating the acoustic stimulation nerve modulation treatment scheme according to claim 1, wherein when the auditory detection signals of two sides of a human body are obtained, the subjective detection signals and/or objective detection signals of auditory nerves of each side of the human body are respectively input into a signal preprocessing unit through a brain-computer interface for signal typing and conversion analysis, the subjective detection comprises but not limited to hearing threshold under living noise environment, ultra-high frequency pure-tone hearing detection extending from 1Hz to 8KHz to more than 10KHz under normal hearing frequency environment, the semi-objective semi-subjective detection comprises but not limited to multi-channel multi-mode psychoacoustic tinnitus matching or reduction detection for complex tinnitus sound reduction, the signal components of each channel are respectively expressed in simple sound elements, sound intensity, frequency range and/or melody, the simple sound elements comprise but not limited to pure tone, pulse and noise, and the objective detection comprises auditory brainstem evoked potential ABR detection and/or auditory steady evoked potential ASSR detection for auditory brainstem potential wave change.
3. The device for formulating an acoustic stimulation neuromodulation therapy scheme according to claim 1, wherein the mathematical transformation and analysis of the signal wave includes, but is not limited to, fast fourier transform FFT analysis of the time domain and the frequency domain of the signal, wavelet transform WT time-frequency analysis, power spectral density analysis of the brain wave signal, and neural network attribute analysis, and the signal characteristic parameters include, but are not limited to, a signal waveform, amplitude a m, and frequency f m corresponding to each signal component.
4. The apparatus according to claim 1, wherein the complex waveforms expressed by the dynamic changes of the neurophysiologic activities and the cognitive psychological activities and expressed by the interactions respectively are further subjected to a typing analysis, including but not limited to a waveform mutation analysis, a notch analysis of a signal curve mutation, a specific division analysis, and further adjusted and optimized by the typing and conversion analysis of subjective and/or objective detection signals reflecting physiological and psychological parts of the nerve dysfunction disease.
5. The apparatus according to claim 4, wherein the characteristic parameters of the signal components are further adjusted and optimized based on the results of the typing and conversion analysis of the human neuro-physiological test signals in combination with clinical subjective diagnostic information including, but not limited to, clinical characteristic information about sleep, anxiety, depression, and acoustic sensitivity and psycho-subjective scale evaluation information thereof.
6. The apparatus of claim 1, wherein the signal waveform modulation includes, but is not limited to, triangular wave modulation, rectangular wave modulation, pulse wave modulation, sawtooth wave modulation, trough extension modulation, period of change modulation, and notch-knocking modulation.
7. The apparatus for formulating an acoustic stimulation neuromodulation therapy regimen in accordance with claim 1, wherein the parameters of the acoustic stimulation therapy regimen include, but are not limited to, the amplitude and frequency of the modulated signals, the weight of the contribution of the relevant channel or frequency band in the multi-channel signal superposition, the frequency of daily therapy, and the course of therapy.
8. The device for formulating the acoustic stimulation nerve regulation and control treatment scheme according to claim 1, wherein the system for formulating the acoustic stimulation nerve regulation and control treatment scheme comprises a nerve dysfunction detection signal input interface unit, a signal preprocessing unit, an acoustic stimulation scheme formulating and storing unit and an acoustic stimulation scheme implementing unit, wherein the acoustic stimulation scheme implementing unit inputs the fluctuation signals which are detected by human hearing and/or non-hearing and express brain activities in different physical quantities into the signal preprocessing unit through a brain-computer interface and the signal input interface unit so as to perform parting and conversion analysis on the nerve electrophysiological signals, the acoustic stimulation scheme formulating and storing unit respectively and individually formulates acoustic stimulation treatment schemes corresponding to two ear sides according to the processing information output by the signal preprocessing unit, so as to perform comprehensive physical intervention acoustic stimulation noninvasive nerve regulation and control accurate treatment by combining physiology and psychology, and the acoustic stimulation scheme implementing unit inputs the acoustic stimulation signals into an auditory meatus and converts the acoustic signals into a stimulation electric signal through a cochlea, and enters the brain center through an auditory pathway so as to perform electric nerve regulation and control on the brain nervous system, thereby realizing nerve accurate treatment on various refractory nerve dysfunction diseases and performing personalized nerve regulation and control slow nerve regulation and control complete multiple period management.
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