CN113679818A

CN113679818A - Composition for treating gout and rheumatoid osteoarthritis and preparation method thereof

Info

Publication number: CN113679818A
Application number: CN202111194645.XA
Authority: CN
Inventors: 邱衍臣; 邱莉雅; 邱婧铭; 商书畅
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-10-13
Filing date: 2021-10-13
Publication date: 2021-11-23

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a composition for treating gout and rheumatoid osteoarthritis and a preparation method thereof. The composition is prepared from astragalus root, white atractylodes rhizome, poria cocos, chamomile, honey-fried licorice root, notopterygium root, ledebouriella root, schizophragma integrifolia, achyranthes root, Ligusticum wallichii, Bupleurum root, trogopterus dung, myrrh, white mustard seed, fried fennel, dried ginger, cassia bark and prepared aconite root in optimum proportion. In the formula, the astragalus has the effects of tonifying spleen and middle warmer, lifting yang and sinking, benefiting defense and consolidating exterior, promoting urination, removing toxin and promoting granulation; bai Zhu, drying dampness and inducing diuresis; poria, with the effects of inducing diuresis to alleviate edema, and optionally flos Chrysanthemi, radix Glycyrrhizae Preparata, Notopterygii rhizoma, radix Saposhnikoviae, cortex Schizophragmatis Integrifolii Radicis, Achyranthis radix, rhizoma Ligustici Chuanxiong, bupleuri radix, Oletum Trogopterori, Myrrha, semen Sinapis Albae, parched fructus Foeniculi, Zingiberis rhizoma, cortex Cinnamomi Japonici and radix Aconiti lateralis Preparata. The composition is a complete prescription, and has effects of activating qi-flowing, resolving stagnation, clearing heat, eliminating dampness, dispelling pathogenic wind, promoting blood circulation and removing blood stasis. The preparation method of the composition is simple and convenient, and the obtained finished product has stable dosage form and is convenient to take.

Description

Composition for treating gout and rheumatoid osteoarthritis and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition for treating gout and rheumatoid osteoarthritis and a preparation method thereof.

Background

Gout is caused by the fact that the uric acid content in a patient is increased sharply, and the gout belongs to the disease of middle-dampness in traditional Chinese medicine. Moisture enters the joint marrow and the patient experiences sudden severe pain in one or more joints. The disease usually occurs suddenly at night, and the joint is red, swollen, hot and painful.

Rheumatism is caused in the bone and enters the bone marrow. Pain is intolerable, hands and feet are dragged, waist ridge is 20251, and rachitis cannot be got up in the bed in the year of age and cannot be obtained. The bony prominences present hard tophus agglomerates.

Rheumatoid arthritis, which is less painful than gout, occurs between the condyloma. The finger interphalangeal joints, metacarpophalangeal joints, wrist and other small joints are the first to get ill, morning stiffness, swelling, pain and serious deformity of joints.

The common characteristics of the two diseases are as follows: lesions all occur in the bone. One in the bone marrow and one in the condyle. In TCM, kidneys govern bones, so both diseases are directly related to kidneys. Wind-dampness enters meridians and collaterals easily and is difficult to remove. Since bone marrow belongs to kidney, kidney can tonify but not discharge, wind-damp can hurt kidney, kidney injury can prevent qi from being weakened, so it can not be eliminated.

Therefore, both of the above diseases are difficult to treat, and the common drugs for treating rheumatism hardly reach the focus of infection, so the treatment of the disease is very difficult. However, kidneys cannot discharge. However, there is a therapy called "fu-borrowing therapy" in traditional Chinese medicine. That is, other viscera can be used to replace renal purging therapy to eliminate rheumatism in bone marrow. This problem is readily solved.

Disclosure of Invention

In order to solve the problems in the prior art, the invention aims to provide a composition for treating gout and rheumatoid osteoarthritis and a preparation method thereof.

The technical scheme adopted by the invention is as follows: the composition for treating gout and rheumatoid osteoarthritis is mainly prepared from the following raw materials in parts by mass:

10-40 parts of astragalus membranaceus, 5-20 parts of bighead atractylodes rhizome, 5-20 parts of poria cocos, 3-12 parts of chamomile, 0.5-4 parts of honey-fried licorice root, 0.5-2 parts of notopterygium root, 0.5-2 parts of divaricate saposhnikovia root, 5-15 parts of schizophragma integrifolium, 5-15 parts of achyranthes root, 0.3-6 parts of ligusticum wallichii, 0.5-4 parts of radix bupleuri, 0.3-6 parts of trogopterus dung, 0.3-6 parts of myrrh, 3-12 parts of semen brassicae, 0.03-0.1 part of fried fennel, 0.25-1 part of rhizoma zingiberis, 0.5-4 parts of cinnamon and 0.1-0.5 part of monkshood.

Astragalus root, name of traditional Chinese medicine. Is root of Astragalus membranaceus (Fisch.) Bge. of Astragalus of Leguminosae, Astragalus membranaceus (Astragalus membranaceus) Astragalus Memeranaceus (Var.) Bge. Hsiao or Astragalus membranaceus (Fisch.) Bge. Has effects in invigorating spleen, strengthening middle warmer, invigorating yang, lifting sink, invigorating defensive qi, consolidating superficial resistance, promoting urination, removing toxic materials, and promoting granulation. It is mainly indicated for spleen qi deficiency syndrome, lung qi deficiency syndrome, qi deficiency spontaneous sweating syndrome, qi and blood deficiency, ulcer and sore difficult to ulcerate and rot, or difficult to heal for a long time. Sweet in flavor and slightly warm in nature; it enters spleen and lung meridians. Chemical components: separating astragaloside I, astragaloside II, daucosterol, beta-sitosterol, palmitic acid, astragaloside A, B, C, 2', 4' -dihydroxy-5, 6-dimethoxy isoflavan, ursolic acid, choline, betaine, folic acid, calycosin, formononetin and astragaloside I, II, III, IV using triterpene cycloastragaloside as aglycone from radix astragali. The antibacterial component is L-3-hydroxy-9-methoxyl pterocarpan. The Mongolian radix astragali contains soyasaponin, astragalosides I, II, IV, and daucosterol. Contains three kinds of homogeneous polysaccharides including astragalus polysaccharide I, astragalus polysaccharide II and astragalus polysaccharide III, and has two kinds of dextran AG-1 and AG-2 separated and two kinds of heteropolysaccharide AH-l and AH-2 separated. AG-1 and AH-1 have immune promoting effect. Contains flavonoids such as formononetin and calycosin; it also contains 21 amino acids such as asparagine, canavanine, proline and Yttrium, etc., and 14 trace elements such as iron, manganese, zinc and rubidium.

Baizhu, name of Chinese medicine. Is rhizome of Atractylodes macrocephala Koidz of Atractylodes of Compositae. Has effects of invigorating qi, invigorating spleen, eliminating dampness, promoting diuresis, arresting sweating, and preventing miscarriage. It can be used for treating deficiency of spleen-qi, spleen deficiency, stagnation of spleen-qi, spleen deficiency, fluid retention, excessive sweat due to muscle surface weakness, and threatened abortion. Bitter and sweet in taste and warm in nature; it enters spleen and stomach meridians. Chemical components: the Atractylodis rhizoma contains volatile oil, and the oil mainly contains atractylone, atractylenolide A, B and saccharide (mainly mannose and fructose).

Tuckahoe, name of traditional Chinese medicine. Is dried sclerotium of Wolf of Poriacos (Schw.) of Polyporaceae family. Yun Ling is called Yun Ling in Yunnan province, and is superior in quality. Has effects of inducing diuresis to alleviate edema, eliminating dampness, invigorating spleen, and calming heart. It can be used for treating edema, phlegm retention, diarrhea due to spleen deficiency, palpitation, and insomnia. Sweet and light taste, mild in nature; it enters heart, lung and spleen meridians.

The chamomile belongs to the family of compositae, is slightly bitter and sweet in taste, has the effects of helping sleep and moistening skin, and can also improve premenstrual discomfort of women. It can be used for relieving soreness, liver fire, and eye fatigue. Can be used for treating constipation, relieving tension and eye fatigue, moistening lung, and promoting health. Is beneficial to liver function maintenance, nervosity and spasm. Can be used for relieving muscular soreness and migraine caused by common cold, and has beneficial effect on stomach and abdominal nerve. Improving eyesight, clearing liver fire, treating insomnia, lowering blood pressure, improving vitality, and refreshing mind. Improving memory and reducing cholesterol. Scientists found antioxidants and some elements that inhibit microbial growth in camomile oil.

Radix Glycyrrhizae Preparata is a plant of Leguminosae, and is baked with Mel. Radix Glycyrrhizae Preparata contains glycyrrhizin, glycyrrhetinic acid, and Glycyrrhiza polysaccharide, and has antiinflammatory, antiallergic, immunity regulating, antitumor, and analgesic effects. Therefore, the main effects of honey-fried licorice root are to harmonize the middle warmer, relieve urgency, moisten lung, remove toxicity, and harmonize the other drugs. It is commonly indicated for weakness of spleen and stomach, lassitude, palpitation and intermittent pulse, and can relieve subsidiary toxicity. The clinical application of radix Glycyrrhizae Preparata is mostly radix Glycyrrhizae Preparata decoction, which is prepared from radix Glycyrrhizae Preparata as main raw material. Therefore, the efficacy and action of gan-ji-gan-Cao can be analyzed from gan-ji-gan-Cao decoction. According to doctors of all generations, the main effects and actions of the honey-fried licorice decoction are considered as four points, namely the effect of nourishing yin, the effect of replenishing blood, the effect and action of tonifying qi and blood, and the coordination of yin and yang.

Notopterygium root, rhizoma Et radix Notopterygii, the name of Chinese medicine. Is rhizome and root of Notopterygium inccisum Ting ex H.T. Chang or Notopterygium forbesii Boiss. Has the effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, eliminating dampness, and relieving pain. It can be used for treating wind-cold type common cold and arthralgia due to wind-cold-dampness. Pungent and bitter taste, warm nature; it enters bladder and kidney meridians. Chemical components: the product contains volatile oil, beta-sitosterol, coumarin compound, phenolic compound, daucosterol, imperatorin, organic acid and alkaloid.

Ledebouriella root, radix Saposhnikoviae, 5-10g of Chinese medicine. Is root of Saposhnikovia divaricata (Turcz.) Schischk. of Saposhnikovia of Umbelliferae. Has the effects of dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm. It can be used for treating exterior syndrome due to exogenous pathogenic factors, rubella pruritus, rheumatalgia, and tetanus. Pungent and sweet in flavor and slightly warm in nature; it enters bladder and liver meridians. Chemical components: the product contains volatile oil, mannitol, beta-sitosterol, picroside, phenols, polysaccharides, organic acids, etc. The pharmacological action is as follows: the product has antipyretic, antiinflammatory, tranquilizing, analgesic, anticonvulsive, and antiallergic effects. The divaricate saposhnikovia root fresh juice has a certain antibacterial effect on pseudomonas aeruginosa and staphylococcus aureus, the decoction has different degrees of inhibition effects on dysentery bacillus, hemolytic streptococcus and the like, and the decoction has the effect of enhancing the phagocytic function of abdominal cavity macrophages of mice.

The name of the traditional Chinese medicine is Zuangfeng. Is root and stem of Schizophragmatergrifolia (Franch.) Oliv. of Saxifragaceae. Is distributed in southwest, Shaanxi, Anhui, Zhejiang, Jiangxi, Fujian, Taiwan, Hubei, Hunan, Guangdong, Guangxi, etc. Has the effects of relaxing muscles and tendons, activating collateral flow, expelling pathogenic wind, and promoting blood circulation. It is commonly used for arthralgia due to wind-dampness and soreness of joints of limbs. Bland in flavor and cool in nature. It enters spleen meridian. The pharmacological action is as follows: 1. can inhibit influenza virus. 2. Can increase blood sugar.

Achyranthes bidentata, the name of Chinese medicine. Is prepared from radix Achyranthis bidentatae (Achyranthus bidentata) BI. of Achyranthus of Amaranthaceae and radix Cyathulae (sweet Achyranthes bidentata) Cyathula officinalis Kuan of Cyathula officinalis of Cyathula of Amaranthaceae. Has the effects of promoting blood circulation, stimulating the menstrual flow, tonifying liver and kidney, strengthening muscles and bones, inducing diuresis, treating stranguria and guiding fire (blood) downwards. It can be used for treating amenorrhea, dysmenorrhea, abdominal pain during menstruation, retained afterbirth, traumatic injury, soreness of waist and knees, debility and weakness of lower limbs, stranguria, edema, dysuria, headache, vertigo, toothache, aphtha of the mouth and tongue, hematemesis, and epistaxis. Bitter, sweet and sour in taste and mild in nature; it enters liver and kidney meridians. Chemical components: radix Achyranthis contains triterpenoid saponin (prepared by hydrolyzing to oleanolic acid and sugar), ecdysterone, inocosterone, and radix Achyranthis bidentatae sterone, and polysaccharides. In addition, Achyranthis radix also contains 12 amino acids such as arginine, alkaloids, coumarins, and trace elements such as iron and copper.

Rhizoma Ligustici Chuanxiong, named as Chinese medicine, is dried rhizome of Ligusticum chuanxiong Hort. Has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. It is mainly used for treating thoracic obstruction and heart pain due to heart vessel stagnation, hypochondriac distending pain due to liver depression and qi stagnation, chest and hypochondriac pricking pain due to liver blood stagnation, traumatic injury due to blood stasis, pyocutaneous disease and swelling pain, menoxenia, amenorrhea and dysmenorrhea, puerperal blood stasis and pain, lochiorrhea, various headaches and rheumatism pain. Pungent taste and warm nature; it enters liver, gallbladder and pericardium meridians. Chemical components: the product contains alkaloid (such as ligustrazine), volatile oil (mainly including ligustilide and cholestene), phenolic substance (such as ferulic acid), lactone, vitamin A, folic acid, sucrose, sterol, fatty oil, etc.

Bupleurum root, the name of Chinese medicine. Is dried root of Bupleurum chinense DC or Bupleurum scorzonerifolium Willd. Has the effects of relieving exterior syndrome, relieving fever, dispersing stagnated liver qi for relieving qi stagnation, and lifting yang qi. It is mainly used for treating exterior syndrome fever, shaoyang syndrome, liver depression and qi stagnation, qi deficiency sinking, organ prolapse, fever abatement and malaria interception. Bitter and pungent taste, slightly cold nature; it enters liver and gallbladder meridians. Chemical components: radix bupleuri contains alpha-spinasterol, chaenomeles alcohol, saikoside a, c and d, and volatile oil. Radix bupleuri chinensis contains saikoside a, c, d, volatile oil, bupleurum alcohol, chaulmoogra alcohol, alpha-spinasterol, etc.

Trogopterus dung, the name of traditional Chinese medicine. Dried feces of the Trogopterus xanthipes Milne-Edwards, which is a compound-rodent Trogopterus xanthipes of the family Trogopterus. Has effects of promoting blood circulation, relieving pain, removing blood stasis, and stopping bleeding. It can be used for treating pain due to blood stasis, such as thoracic obstruction, heart pain, hypochondriac pain, dysmenorrhea, amenorrhea, puerperal abdominal pain due to blood stasis, fracture, and hemorrhage due to blood stasis and blood stasis. Bitter, salty and sweet in taste, warm in nature; it enters liver meridian. Chemical components: contains triterpenes (such as triterpenic acid, trogopterus dung triterpenic acid, etc.), phenolic acid, nitrogen-containing compounds (urea, uric acid), vitamin A substances, and resin.

Myrrh, name of traditional Chinese medicine. Is oleoresin exuded from bark of Commiphora myrrha Engl. or other plants of the same genus of Commiphora of Burseraceae. Has effects of promoting blood circulation, relieving pain, eliminating swelling, and promoting granulation. Can be used for treating traumatic injury, swelling and pain due to blood stasis, carbuncle, cellulitis, swelling and pain, unhealed skin ulcer, chest pain, hypochondriac pain, cardialgia, dysmenorrhea, puerperal abdominal pain, rheumatalgia, and abdominal mass. Pungent, bitter and neutral in flavor; it enters heart, liver and spleen meridians. Chemical components: comprises Myrrha resin, volatile oil (eugenol, etc.), gum, small amount of bitter substances, and also comprises bisabolol, formic acid, acetic acid, oxidase, etc.

White mustard seed, the name of traditional Chinese medicine. Is seed of Brassicaceae plant Sinapis alba L. Has effects of warming lung, eliminating phlegm, activating qi-flowing, resolving hard mass and relieving swelling. It is mainly used for treating cold phlegm cough and asthma, fluid retention, dorsal furuncle, multiple abscess, numbness of limbs, and arthralgia. Pungent taste and warm nature; it enters lung and stomach meridians. Chemical components: the seeds contain glucosinolates and are filled with sinapioside. It also contains fatty oil, myrosinase, sinapine and lysine, arginine, histidine, etc. Also contains 4-hydroxybenzoyl choline and 4-hydroxybenzyl methylamine.

Parched fructus Foeniculi is dried mature fruit of Foeniculum vulgare of Umbelliferae. Fruits (fennel) are used as spices and also as pharmaceuticals, and roots, leaves, and herbs can be used as medicines. The name of the traditional Chinese medicine. Is dried mature fruit of Foeniculum vulgare Mill of Foeniculum of Umbelliferae. Has effects in warming kidney and liver, promoting qi circulation, relieving pain, and regulating stomach function. It can be used for treating abdominal pain due to hernia of cold type, testis tenesmus, abdominal psychroalgia, anorexia, vomiting, diarrhea, hypochondriac pain, lumbago due to kidney deficiency, and dysmenorrhea. Pungent taste and warm nature; it enters liver, kidney, bladder and stomach meridians. Chemical components: contains volatile oil 3-6% and trans-anethole, limonene, fenchyl ketone, estragole, gamma-terpinene, alpha-pinene, myrcene, etc. as main components. The fat oil contains about 18% of fatty acid, wherein the fatty acid mainly comprises petroselinic acid, oleic acid, linoleic acid, palmitic acid, arachidic acid and the like. And contains small amount of anethole, anisaldehyde, etc.

Dried ginger, named as traditional Chinese medicine. Is dried rhizome of Zingiber officinale Rosc. of Zingiberaceae. Has the effects of warming spleen and stomach for dispelling cold, restoring yang and dredging collaterals, and warming lung and resolving fluid retention. It can be used for treating abdominal psychroalgia, emesis, diarrhea, yang exhaustion, cough and asthma due to cold-fluid retention, and arthralgia due to cold-dampness. Pungent taste and hot property; it enters spleen, stomach, heart and lung meridians. Chemical components: contains volatile oil about 2%, and mainly contains zingiberene, phellandrene, camphene, zingiberone, gingerol, zingiberone, borneol, gingerol, citral, etc. It also contains resin, starch and amino acids. The pharmacological action is as follows: rhizoma Zingiberis has tranquilizing, analgesic, antiinflammatory, anticoagulant, anoxia resisting, and other effects, and has effects on cardiovascular function, adrenal cortex function, and digestive system.

Cinnamon, also known as cinnamon, cinnamon bark or cinnamon bark, is the general name given to the bark of Cinnamomum japonicum, Cinnamomum cassia or Cinnamomum cassia of Lauraceae. The product is a common traditional Chinese medicine, and is also a food spice or a cooking seasoning. Aromatic oil or cassia oil can be extracted from plant parts such as bark, branch, leaf, fruit and flower stalk, and can be used in food, beverage, cigarette and medicine, but is often used as essence for spice, cosmetics and daily necessities. The oil yield of bark is 2.15%, the oil yield of cassia twig is 0.35%, the oil yield of cassia leaf is 0.39%, and the oil yield of cassia seed (young fruit) is 2.04%. The bark is called cinnamon. The bark of Cinnamomum japonicum contains volatile oil about 1%, and contains phellandrene, eugenol, and methyl eugenol. The leaf contains about 1% of volatile oil, about 60% of safrole, about 3% of eugenol, 1, 8-escin and the like. The bark of the cinnamomum tenuifolia contains about 1% of volatile oil and 12.8% of tannin. The leaf contains about 1% volatile oil. The seeds contain 40% of fatty oil. The pharmacological effects of cinnamaldehyde and eugenol contained in cortex Cinnamomi include cortex Cinnamomi and flos Caryophylli strip. Cinnamon bark, cortex Cinnamomi, pungent and sweet in flavor, warmly retention, enters kidney, spleen and bladder meridians. Has effects of invigorating primordial qi, warming spleen and stomach, removing cold accumulation, dredging collaterals, relieving pain and relieving diarrhea. It can be used for treating decline of vital gate fire, cold limbs, slight pulse, yang exhaustion, asthenia, abdominal pain, diarrhea, hernia, cold pain of waist and knee, yin gangrene and multiple abscess through cortex Cinnamomi Japonici (side surface), and floating yang. The pharmacological action is as follows: 1. warming kidney and strengthening yang: can be used for treating intolerance of cold due to kidney yang deficiency, cold limbs, cold pain of waist and knee joint, and asthenic asthma and adverse rising of qi due to kidney failure to receive qi; 2. warming middle energizer to dispel cold: for cold pain in the stomach and abdominal pain and diarrhea due to deficiency-cold of spleen and stomach, it is often combined with gan Jiang and Fu Zi to relieve pain in 3, warm meridians and alleviate pain: has effects in warming and dredging blood vessels, dispelling cold, and relieving pain, and can be used for treating dysmenorrhea and limb pain caused by cold accumulation and qi stagnation. The product is pungent, sweet and hot, pure yang with dryness and strong heat, and good at warming the middle-jiao and the lower-jiao to dispel cold and alleviate pain, and red color enters blood to promote qi and blood growth, so it is the essential herb for spleen-kidney yang deficiency, cold accumulation and pain, deficiency-cold of qi and blood, etc.

Radix Aconiti lateralis, also known as Aconitum carmichaeli or aconite, also known as Aconitum kusnezoffii, Aconitum carmichaeli, herba Centipedae, flos Ferulae, WUDU, Latin Wen name: aconitum carmichaeli Debx is processed product of seed root of Aconitum plant of Ranunculaceae. Mainly produced in Sichuan, Hubei, Hunan, etc. of China. Collected in the late 6 th to the early 8 th of the month, and the mother root, fibrous root and silt are removed, which is called as "mud Fu Zi". Processing into salty radix Aconiti lateralis Preparata, black radix Aconiti lateralis Preparata, rhizoma Typhonii, radix Aconiti lateralis Preparata, and processed radix Aconiti lateralis. It belongs to interior-warming herbs. The first product of rescuing from collapse by restoring yang in Chinese herbs. The functional indications are as follows: reviving yang and rescuing from collapse, tonifying fire and supporting yang, dispelling cold and relieving pain. It is indicated for yang deficiency due to exuberant yin, profuse sweat, yang exhaustion, vomiting, syncope, psychroalgia of heart and abdomen, diarrhea and dysentery of spleen, beriberi, edema, infantile chronic convulsion, arthralgia due to wind-cold-dampness, lame spasm, impotence, cold womb, carbuncle of yin, ulcer and fistula, and all the diseases of cold pertinence. The pharmacological action is as follows: the radix Aconiti lateralis has effects of increasing myocardial contraction force, increasing heart rate, increasing cardiac output, and increasing oxygen consumption of myocardium. Radix Aconiti lateralis has effects of dilating blood vessel, increasing blood flow, and improving blood circulation. The effect of Fu Zi on blood pressure is both pressure-increasing and pressure-lowering, and is related to its components. The effect of Fu Zi for restoring yang and treating mainly is based on the action of heart-strengthening to resist shock. The monkshood has obvious effect of resisting bradyarrhythmia. The aconite decoction has obvious inhibition effect on acute inflammation models.

Preferably, the composition is mainly prepared from the following raw materials in parts by mass:

15-38 parts of astragalus membranaceus, 10-18 parts of bighead atractylodes rhizome, 10-18 parts of poria cocos, 5-10 parts of chamomile, 1-3 parts of honey-fried licorice root, 0.8-1.5 parts of notopterygium root, 0.8-1.5 parts of divaricate saposhnikovia root, 8-12 parts of schizophragma integrifolium, 8-12 parts of radix achyranthis bidentatae, 1-4 parts of ligusticum wallichii, 1-3 parts of radix bupleuri, 1-4 parts of trogopterus dung, 1-4 parts of myrrh, 5-8 parts of semen brassicae, 0.05-0.08 part of fried fennel, 0.5-0.8 part of dried ginger, 1-3 parts of cinnamon and 0.2-0.4 part of monkshood.

30 parts of astragalus membranaceus, 15 parts of bighead atractylodes rhizome, 15 parts of poria cocos, 8 parts of chamomile, 2 parts of honey-fried licorice root, 1 part of notopterygium root, 1 part of divaricate saposhnikovia root, 10 parts of schizophragma integrifolium, 10 parts of achyranthes root, 3 parts of ligusticum wallichii, 2 parts of radix bupleuri, 3 parts of trogopterus dung, 3 parts of myrrh, 6 parts of semen brassicae, 0.06 part of fried fennel, 0.6 part of dried ginger, 2 parts of cinnamon and 0.3 part of monkshood.

The monkshood used in the formula is not raw monkshood but prepared monkshood. The dose of prepared aconite is small, only 0.5 g, and actually each dose is only 0.0125 g. Therefore, the toxicity is completely negligible, and the safety is absolute. Moreover, the licorice root can detoxify the aconite root, so the Chinese medicinal preparation is safe and reliable. Furthermore, the treatment is taken only 10 days to the right, and is not taken for a long time.

Preferably, the composition is a pill or liquid formulation.

A preparation method of a composition for treating gout and rheumatoid osteoarthritis comprises the following steps when the composition is a pill: selecting radix astragali, Atractylodis rhizoma, Poria, flos Chrysanthemi, radix Glycyrrhizae Preparata, Notopterygii rhizoma, radix Saposhnikoviae, cortex Schizophragmatis Integrifolii Radicis, Achyranthis radix, rhizoma Ligustici Chuanxiong, bupleuri radix, Oletum Trogopterori, Myrrha, semen Sinapis Albae, parched fructus Foeniculi, Zingiberis rhizoma, cortex Cinnamomi Japonici and radix Aconiti lateralis according to corresponding proportion, mixing, pulverizing, sieving, adding solvent, and mixing to obtain pill.

Preferably, the astragalus, the bighead atractylodes rhizome, the poria cocos, the chamomile, the honey-fried licorice root, the notopterygium root, the divaricate saposhnikovia root, the schizophragma integrifolia, the achyranthes root, the szechuan lovage rhizome, the radix bupleuri, the trogopterus dung, the myrrh, the white mustard seed, the fried fennel, the dried ginger, the cassia bark and the monkshood are selected, mixed, crushed and sieved by a 800-mesh and 1000-mesh sieve.

Preferably, the solvent is a mixture of water and honey;

the proportion of the water and the honey is 0.3-0.8 wt%: 0.2-0.7 wt%;

the weight ratio of the total mass of the mixed astragalus, bighead atractylodes rhizome, poria cocos, chamomile, honey-fried licorice root, notopterygium root, divaricate saposhnikovia root, schizophragma integrifolia, achyranthes root, szechuan lovage rhizome, Chinese thorowax root, trogopterus dung, myrrh, white mustard seed, fried fennel, dried ginger, cassia bark and monkshood to the solvent is 1: 0.5-0.8 wt%.

A preparation method of a composition for treating gout and rheumatoid osteoarthritis comprises the following steps when the composition is a liquid preparation: selecting radix astragali, rhizoma Atractylodis Macrocephalae, Poria, flos Chrysanthemi, radix Glycyrrhizae Preparata, rhizoma Et radix Notopterygii, radix Saposhnikoviae, cortex schizophragmatis integrifolii radicis, radix Achyranthis bidentatae, rhizoma Chuanxiong, radix bupleuri, Oletum Trogopterori, Myrrha, semen Sinapis, parched fructus Foeniculi, rhizoma Zingiberis, cortex cinnamomi japonici, and radix Aconiti lateralis Preparata according to a certain proportion, mixing, soaking, decocting, and filtering to remove residues to obtain a liquid preparation.

Preferably, the soaking is performed by using water, and the soaking time is 20-30 minutes.

Preferably, the decoction temperature is 80-90 ℃; the decoction time is 30-55 minutes.

The invention has the beneficial effects that:

the invention provides a composition for treating gout and rheumatoid osteoarthritis, which is prepared from astragalus root, white atractylodes rhizome, poria cocos, chamomile, honey-fried licorice root, notopterygium root, ledebouriella root, schizophragma integrifolium, achyranthes root, Ligusticum wallichii, Bupleurum root, trogopterus dung, myrrh, white mustard seed, stir-fried fennel fruit, dried ginger, cassia bark and prepared aconite root in optimum proportion.

In the formula, the astragalus has the effects of tonifying spleen and middle warmer, lifting yang and sinking, benefiting defense and consolidating exterior, promoting urination, removing toxin and promoting granulation; bai Zhu, drying dampness and inducing diuresis; poria, with the effects of inducing diuresis to alleviate edema, and optionally flos Chrysanthemi, radix Glycyrrhizae Preparata, Notopterygii rhizoma, radix Saposhnikoviae, cortex Schizophragmatis Integrifolii Radicis, Achyranthis radix, rhizoma Ligustici Chuanxiong, bupleuri radix, Oletum Trogopterori, Myrrha, semen Sinapis Albae, parched fructus Foeniculi, Zingiberis rhizoma, cortex Cinnamomi Japonici and radix Aconiti lateralis Preparata. The composition is a complete prescription, and has effects of activating qi-flowing, resolving stagnation, clearing heat, eliminating dampness, dispelling pathogenic wind, promoting blood circulation and removing blood stasis.

The preparation method of the composition is simple and convenient, and the obtained finished product has stable dosage form and is convenient to take.

Detailed Description

The present invention is further illustrated below with reference to specific examples. It will be appreciated by those skilled in the art that the following examples, which are set forth to illustrate the present invention, are intended to be part of the present invention, but not to be construed as limiting the scope of the present invention. The reagents used are all conventional products which are commercially available.

Example 1:

a preparation method of a composition for treating gout and rheumatoid osteoarthritis comprises the following steps when the composition is a pill: selecting 10g of astragalus root, 5 g of white atractylodes rhizome, 5 g of tuckahoe, 3 g of chamomile, 0.5 g of honey-fried licorice root, 0.5 g of notopterygium root, 0.5 g of ledebouriella root, 5 g of schizophragma integrifolium, 5 g of achyranthes root, 0.3 g of rhizoma ligustici wallichii, 0.5 g of radix bupleuri, 0.3 g of trogopterus dung, 0.3 g of myrrh, 3 g of white mustard seed, 0.03 g of fried fennel, 0.25 g of dried ginger, 0.5 g of cassia bark and 0.1 g of monkshood according to corresponding proportion, mixing, crushing, sieving by a 800-mesh sieve, adding 9.55 g of water and 22.3 g of honey, and uniformly mixing to obtain the finished product pill.

A preparation method of a composition for treating gout and rheumatoid osteoarthritis comprises the following steps when the composition is a liquid preparation: selecting 10g of astragalus root, 5 g of white atractylodes rhizome, 5 g of tuckahoe, 3 g of chamomile, 0.5 g of honey-fried licorice root, 0.5 g of notopterygium root, 0.5 g of ledebouriella root, 5 g of schizophragma integrifolium, 5 g of achyranthes root, 0.3 g of rhizoma ligustici wallichii, 0.5 g of radix bupleuri, 0.3 g of trogopterus dung, 0.3 g of myrrh, 3 g of white mustard seed, 0.03 g of fried fennel, 0.25 g of dried ginger, 0.5 g of cassia bark and 0.1 g of monkshood according to corresponding proportion, mixing, soaking for 20 minutes, decocting for 30 minutes at 80 ℃, filtering residues, and obtaining the finished product liquid preparation.

Example 2:

a preparation method of a composition for treating gout and rheumatoid osteoarthritis comprises the following steps when the composition is a pill: selecting 40 g of astragalus root, 20 g of largehead atractylodes rhizome, 20 g of tuckahoe, 12 g of chamomile, 4 g of honey-fried licorice root, 2 g of notopterygium root, 2 g of divaricate saposhnikovia root, 15 g of schizophragma integrifolium, 15 g of twotooth achyranthes root, 6 g of szechuan lovage rhizome, 4 g of radix bupleuri, 6 g of trogopterus dung, 6 g of myrrh, 12 g of white mustard seed, 0.1 g of fried fennel, 1 g of dried ginger, 4 g of cassia bark and 0.5 g of monkshood according to corresponding proportion, mixing, crushing, sieving by a 1000-mesh sieve, adding 42.4 g of water and 42.4 g of honey, and uniformly mixing to obtain the finished pill.

A preparation method of a composition for treating gout and rheumatoid osteoarthritis comprises the following steps when the composition is a liquid preparation: selecting 40 g of astragalus root, 20 g of bighead atractylodes rhizome, 20 g of poria cocos, 12 g of chamomile, 4 g of honey-fried licorice root, 2 g of notopterygium root, 2 g of divaricate saposhnikovia root, 15 g of schizophragma integrifolium, 15 g of achyranthes root, 6 g of ligusticum wallichii, 4 g of radix bupleuri, 6 g of trogopterus dung, 6 g of myrrh, 12 g of semen brassicae, 0.1 g of fried fennel, 1 g of dried ginger, 4 g of cassia bark and 0.5 g of monkshood according to corresponding proportion, mixing, soaking for 30 minutes, decocting for 55 minutes at 90 ℃, and filtering residues to obtain a finished liquid preparation.

Example 3:

a preparation method of a composition for treating gout and rheumatoid osteoarthritis comprises the following steps when the composition is a pill: selecting 15 g of astragalus root, 10g of white atractylodes rhizome, 10g of tuckahoe, 5 g of chamomile, 1 g of honey-fried licorice root, 0.8 g of notopterygium root, 0.8 g of divaricate saposhnikovia root, 8 g of schizophragma integrifolium, 8 g of achyranthes root, 1 g of szechuan lovage rhizome, 1 g of radix bupleuri, 1 g of trogopterus dung, 1 g of myrrh, 5 g of white mustard seed, 0.05 g of fried fennel, 0.5 g of dried ginger, 1 g of cassia bark and 0.2 g of monkshood according to corresponding proportion, mixing, crushing, sieving by a 800-mesh sieve, adding 44.38 g of water and 11.1 g of honey, and uniformly mixing to obtain the finished pill.

A preparation method of a composition for treating gout and rheumatoid osteoarthritis comprises the following steps when the composition is a liquid preparation: selecting 15 g of astragalus root, 10g of white atractylodes rhizome, 10g of tuckahoe, 5 g of chamomile, 1 g of honey-fried licorice root, 0.8 g of notopterygium root, 0.8 g of divaricate saposhnikovia root, 8 g of schizophragma integrifolium, 8 g of achyranthes root, 1 g of szechuan lovage rhizome, 1 g of radix bupleuri, 1 g of trogopterus dung, 1 g of myrrh, 5 g of white mustard seed, 0.05 g of fried fennel, 0.5 g of dried ginger, 1 g of cassia bark and 0.2 g of monkshood according to corresponding proportion, mixing, soaking for 20 minutes, decocting for 55 minutes at 90 ℃, and filtering residues to obtain a finished liquid preparation.

Example 4:

a preparation method of a composition for treating gout and rheumatoid osteoarthritis comprises the following steps when the composition is a pill: selecting 38 g of astragalus root, 18 g of bighead atractylodes rhizome, 18 g of poria cocos, 10g of chamomile, 3 g of honey-fried licorice root, 1.5 g of notopterygium root, 1.5 g of divaricate saposhnikovia root, 12 g of schizophragma integrifolium, 12 g of achyranthes root, 4 g of ligusticum wallichii, 3 g of radix bupleuri, 4 g of trogopterus dung, 4 g of myrrh, 8 g of semen brassicae, 0.08 g of fried fennel, 0.8 g of dried ginger, 3 g of cassia bark and 0.4 g of monkshood according to corresponding proportion, mixing, crushing, sieving by a 1000-mesh sieve, adding 56.5 g of water and 56.5 g of honey, and uniformly mixing to obtain the finished pill.

A preparation method of a composition for treating gout and rheumatoid osteoarthritis comprises the following steps when the composition is a liquid preparation: selecting 38 g of astragalus, 18 g of bighead atractylodes rhizome, 18 g of poria cocos, 10g of chamomile, 3 g of honey-fried licorice root, 1.5 g of notopterygium root, 1.5 g of divaricate saposhnikovia root, 12 g of schizophragma integrifolium, 12 g of achyranthes root, 4 g of ligusticum wallichii, 3 g of radix bupleuri, 4 g of trogopterus dung, 4 g of myrrh, 8 g of semen brassicae, 0.08 g of fried fennel, 0.8 g of dried ginger, 3 g of cassia bark and 0.4 g of monkshood according to corresponding proportions, mixing, soaking for 30 minutes, decocting for 30 minutes at 80 ℃, and filtering residues to obtain a finished liquid preparation.

Example 5:

a preparation method of a composition for treating gout and rheumatoid osteoarthritis comprises the following steps when the composition is a pill: selecting 30 g of astragalus root, 15 g of bighead atractylodes rhizome, 15 g of poria cocos, 8 g of chamomile, 2 g of honey-fried licorice root, 1 g of notopterygium root, 1 g of divaricate saposhnikovia root, 10g of schizophragma integrifolium, 10g of achyranthes root, 3 g of ligusticum wallichii, 2 g of radix bupleuri, 3 g of trogopterus dung, 3 g of myrrh, 6 g of semen brassicae, 0.06 g of fried fennel, 0.6 g of dried ginger, 2 g of cassia bark and 0.3 g of monkshood according to corresponding proportion, mixing, crushing, sieving by a 1000-mesh sieve, adding 167.94 g of water and 29.18 g of honey, and uniformly mixing to obtain the finished pill.

A preparation method of a composition for treating gout and rheumatoid osteoarthritis comprises the following steps when the composition is a liquid preparation: selecting 30 g of astragalus root, 15 g of bighead atractylodes rhizome, 15 g of poria cocos, 8 g of chamomile, 2 g of honey-fried licorice root, 1 g of notopterygium root, 1 g of divaricate saposhnikovia root, 10g of schizophragma integrifolium, 10g of achyranthes root, 3 g of ligusticum wallichii, 2 g of radix bupleuri, 3 g of trogopterus dung, 3 g of myrrh, 6 g of semen brassicae, 0.06 g of fried fennel, 0.6 g of dried ginger, 2 g of cassia bark and 0.3 g of monkshood according to corresponding proportion, mixing, soaking for 30 minutes, decocting for 30 minutes at 80 ℃, and filtering residues to obtain a finished liquid preparation.

The taking method comprises the following steps:

reducing uric acid: when the finished product is pills, 1 pill is taken as big honeyed pill, 2-3 pills are taken each day, and after the uric acid is normal, the curative effect is consolidated by continuously taking for 10-20 days without relapse.

Gout and rheumatoid diseases are taken 1-2 pills each time according to the weight of the disease, and 2-3 pills each day. After the medicine is taken until the symptoms disappear, the medicine is taken for about 20 days to consolidate the curative effect and no relapse occurs. According to the dosage, the tophus no matter how large or small, can be completely removed in about one week, so that the joint can be recovered as before.

Clinical cases:

patient 1: sex: female, age: 53 years old, Zhannan province, Lingbao county, Yi Zhong Dong che village.

Diagnosis of the condition: for years of rheumatoid diseases, the knee joints have deformation swelling and pain, and the knee joints are treated for many times in local hospitals, and the loxoprofen sodium dispersible tablets, the white paeony root total glycoside capsules, the leflunomide tablets, the diclofenac sodium suppositories and the like have no effect when being taken.

The treatment method comprises the following steps: the pills prepared in the example 5 are used for treating gout by 30 pills, and each pill is taken three times a day; one pill for each day and two pills for each day are used for consolidating the treatment of the eight ingredients with rehmannia pills of 40. The pain is not relieved after taking the medicine for 3 days, and after 6 days.

The treatment results are as follows: the joint swelling disappears, and the medicine is taken completely, so that the joint swelling is not relapsed.

Patient 2: sex: male, age: 50 years old, Wanggang in the bridge area of Xinyang city, Henan.

Diagnosis of the condition: the doctor visits 11 months and 2 days in 2018, and the uric acid is checked for 760 mu mol/L. Gout can be suffered for years, and waist is sour and easy to sweat. Gout is diagnosed.

The treatment method comprises the following steps: the pills prepared in the embodiment 5 are used for treating gout, and 30 pills are taken for one time, three times a day and ten days; the eight-ingredient rehmannia pill is 40 pills, is consolidated for operation, is taken one pill per day, is taken two times per day, and is taken for 20 days.

The treatment results are as follows: the gout does not relapse after the patient feeds back and the medicine is taken until the gout does not relapse.

Patient 3: sex: female, age: 62 years old, people staying in post-house city.

Diagnosis of the condition: uric acid was detected at 462. mu. mol/L at 6 months in 2021, which was slightly higher.

The treatment method comprises the following steps: pellets, 8 pellets, were prepared as in example 5 above. One pill is taken every day, and the pill is taken twice a day; one pill for each day and two pills for each day are 23 pills with 40 pills of eight ingredients and strengthening the recovery.

The treatment results are as follows: the patient fed back that the uric acid content (333 mu mol/L) is normal.

The present invention is not limited to the above alternative embodiments, and any other products in various forms can be obtained by the present invention, and the present invention is within the protection scope of the present invention. The above embodiments should not be construed as limiting the scope of the present invention, and it will be understood by those skilled in the art that modifications may be made to the technical solutions described in the above embodiments, or equivalent substitutions may be made to some or all of the technical features thereof, without departing from the scope of the present invention, and at the same time, such modifications or substitutions may not make the essence of the corresponding technical solutions depart from the scope of the embodiments of the present invention.

Claims

1. The composition for treating gout and rheumatoid osteoarthritis is characterized by being prepared from the following raw materials in parts by mass:

2. The composition for treating gout and rheumatoid osteoarthritis according to claim 1, wherein the composition is prepared from the following raw materials in parts by mass:

3. The composition for treating gout and rheumatoid osteoarthritis according to claim 2, wherein the composition is prepared from the following raw materials in parts by mass:

4. The composition for treating gout, rheumatoid osteoarthritis according to any of claims 1 to 3, wherein the composition is in the form of a pill or a liquid formulation.

5. A method for preparing a composition for the treatment of gout, rheumatoid osteoarthritis as claimed in any of claims 1 to 4, wherein the composition is in the form of a pill, comprising the steps of: selecting radix astragali, Atractylodis rhizoma, Poria, flos Chrysanthemi, radix Glycyrrhizae Preparata, Notopterygii rhizoma, radix Saposhnikoviae, cortex Schizophragmatis Integrifolii Radicis, Achyranthis radix, rhizoma Ligustici Chuanxiong, bupleuri radix, Oletum Trogopterori, Myrrha, semen Sinapis Albae, parched fructus Foeniculi, Zingiberis rhizoma, cortex Cinnamomi Japonici and radix Aconiti lateralis according to corresponding proportion, mixing, pulverizing, sieving, adding solvent, and mixing to obtain pill.

6. The method for preparing a composition for treating gout and rheumatoid osteoarthritis according to claim 5, wherein the selected herbs are radix astragali, rhizoma Atractylodis Macrocephalae, Poria, flos Chrysanthemi, radix Glycyrrhizae Preparata, rhizoma Et radix Notopterygii, radix Saposhnikoviae, cortex schizophragmatis integrifolii radicis, radix Achyranthis bidentatae, rhizoma Chuanxiong, radix bupleuri, Oletum Trogopterori, Myrrha, semen Sinapis, parched fructus Foeniculi, rhizoma Zingiberis, cortex cinnamomi japonici, and radix Aconiti lateralis Preparata, and the mixture is pulverized and sieved with a 800-mesh and 1000-mesh sieve.

7. The method for preparing a composition for treating gout and rheumatoid osteoarthritis according to claim 5, wherein the solvent is a mixture of water and honey;

the proportion of the water and the honey is 0.3-0.8 wt%: 0.2-0.7 wt%;

8. A method for preparing a composition for the treatment of gout and rheumatoid osteoarthritis according to any of claims 1 to 4, wherein the composition is a liquid preparation, comprising the steps of: selecting radix astragali, rhizoma Atractylodis Macrocephalae, Poria, flos Chrysanthemi, radix Glycyrrhizae Preparata, rhizoma Et radix Notopterygii, radix Saposhnikoviae, cortex schizophragmatis integrifolii radicis, radix Achyranthis bidentatae, rhizoma Chuanxiong, radix bupleuri, Oletum Trogopterori, Myrrha, semen Sinapis, parched fructus Foeniculi, rhizoma Zingiberis, cortex cinnamomi japonici, and radix Aconiti lateralis Preparata according to a certain proportion, mixing, soaking, decocting, and filtering to remove residues to obtain a liquid preparation.

9. The method for preparing a composition for treating gout and rheumatoid osteoarthritis according to claim 8, wherein the soaking is performed with water for 20-30 minutes.

10. The method for preparing a composition for treating gout and rheumatoid osteoarthritis according to claim 8, wherein the decoction temperature is 80-90 ℃; the decoction time is 30-55 minutes.