CN113662591A - A Sample Sampling and Collection System Convenient for Tumor Pharmacological Research - Google Patents
A Sample Sampling and Collection System Convenient for Tumor Pharmacological Research Download PDFInfo
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- CN113662591A CN113662591A CN202110067360.3A CN202110067360A CN113662591A CN 113662591 A CN113662591 A CN 113662591A CN 202110067360 A CN202110067360 A CN 202110067360A CN 113662591 A CN113662591 A CN 113662591A
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- 238000005070 sampling Methods 0.000 title claims abstract description 87
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 34
- 230000000144 pharmacologic effect Effects 0.000 title claims description 17
- 210000001503 joint Anatomy 0.000 claims description 33
- 238000003032 molecular docking Methods 0.000 claims description 27
- 230000001174 ascending effect Effects 0.000 claims description 20
- 238000007789 sealing Methods 0.000 claims description 17
- 238000006243 chemical reaction Methods 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 14
- 230000003139 buffering effect Effects 0.000 claims description 12
- 230000002040 relaxant effect Effects 0.000 claims description 6
- 230000000087 stabilizing effect Effects 0.000 claims description 6
- 238000005520 cutting process Methods 0.000 abstract description 4
- 238000000605 extraction Methods 0.000 abstract description 2
- 230000008878 coupling Effects 0.000 description 12
- 238000010168 coupling process Methods 0.000 description 12
- 238000005859 coupling reaction Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 241001330002 Bambuseae Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 210000003701 histiocyte Anatomy 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
- A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0096—Casings for storing test samples
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- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
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- Animal Behavior & Ethology (AREA)
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- Sampling And Sample Adjustment (AREA)
Abstract
本发明属于医疗器械技术领域，尤其是一种便于肿瘤药理研究的样品取样采集系统，现提出如下方案，包括一端开设有开口的取样管，所述取样管的开口处的内圈固定套接有环形结构的收纳套管，所述收纳套管靠近取样管开口处的一端开始有环形结构的滑道，所述滑道滑动套接有半圆形结构的刮刀，所述刮刀的两端均开设有位于取样管内部的对接孔，所述对接孔的内部安装有与刮刀端部固接的对接机构，两组所述对接孔的底部之间开设有同一个环形结构的空腔。本发明方便对患者进行采样切割操作，同时在采样完成后抽出的过程中减小对患者造成的不适，方便将采取的样品进行收集处理，方便医务人员进行采样操作，提高采样操作效率。
The invention belongs to the technical field of medical devices, in particular to a sample sampling and collection system that is convenient for tumor pharmacology research. The following scheme is now proposed, including a sampling tube with an opening at one end, and an inner ring at the opening of the sampling tube is fixedly sleeved with a The receiving sleeve of the annular structure, the end of the receiving sleeve close to the opening of the sampling tube has a slideway of the annular structure, the slideway is slidably sleeved with a scraper with a semicircular structure, and both ends of the scraper are provided with There is a butt hole inside the sampling tube, the inside of the butt hole is installed with a butt mechanism fixed to the end of the scraper, and a cavity of the same annular structure is opened between the bottoms of the two groups of the butt holes. The invention facilitates sampling and cutting operations for patients, reduces discomfort to patients during extraction after sampling, facilitates collection and processing of collected samples, facilitates sampling operations by medical staff, and improves sampling operation efficiency.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a sample sampling and collecting system convenient for tumor pharmacological research.
Background
The tumor is the excessive hyperplasia of a certain local histiocyte in a body, the tumor is divided into benign tumor and malignant tumor, the benign tumor is not very harmful to the body, the malignant tumor is cancer, the harm to the body is very large, when the diagnosis and treatment are carried out on the rectification, a sample needs to be taken from the body of a patient for analysis and research, the existing sampling modes are all carried out by adopting a mode of directly cutting by a cutter, the operation of medical staff is inconvenient, meanwhile, when the cutter enters and exits into the body of the patient, the damage to the patient is easy to cause, especially, the cutter easily causes the damage to the body of the patient in the process of extraction, meanwhile, the collection of the cut sample is inconvenient, and therefore, a sample sampling and collecting system convenient for the pharmacological research of the tumor is needed.
Disclosure of Invention
The invention provides a sample sampling and collecting system convenient for tumor pharmacological research, which solves the problems in the prior art.
In order to achieve the purpose, the invention adopts the following technical scheme:
a sample sampling and collecting system convenient for tumor pharmacological research comprises a sampling tube with one end provided with an opening, wherein an inner ring at the opening of the sampling tube is fixedly sleeved with a receiving sleeve with an annular structure, one end of the receiving sleeve, which is close to the opening of the sampling tube, starts to be provided with a slideway with an annular structure, the slideway is sleeved with a scraper with a semicircular structure in a sliding manner, two ends of the scraper are respectively provided with a butt joint hole positioned in the sampling tube, a butt joint mechanism fixedly connected with the end part of the scraper is arranged in each butt joint hole, a cavity with the same annular structure is arranged between the bottoms of the two groups of butt joint holes, the cavity is positioned in the sampling tube and is coaxial with the sampling tube, a driving mechanism is arranged in each cavity, a containing groove with a circular arc-shaped structure is arranged on the inner side wall of the bottom of each cavity, and a pushing mechanism is connected to the inside of the containing groove in a sliding manner, the bottom of holding tank is seted up the interface channel that the U type is connected, and interface channel's the other end stretches out from sampling tube bottom inside wall, accomodates sheathed tube bottom and installs the material receiving cylinder that cup joints with the sampling tube slip.
Preferably, the driving mechanism comprises a driving ring of an annular structure movably sleeved with the cavity, the top of the driving ring is fixedly connected with a driving ring of an annular structure coaxially arranged with the driving ring, the driving ring is slidably connected with the docking mechanism, the bottom of the driving ring is fixedly connected with a conversion unit, one side of the conversion unit is provided with a guide unit located on the inner side wall of the cavity, the guide unit is slidably connected with the conversion unit, the bottom of the conversion unit is fixedly connected with a pressing plate of an annular structure coaxially arranged with the cavity, and the bottom of the pressing plate is clamped with a docking ring fixedly connected with the pushing mechanism.
Preferably, docking mechanism is including the connecting plate that is located the scraper blade both ends and the circular structure that cup joints with the sampling tube inside wall slip, the one end rigid coupling that the connecting plate is close to the scraper blade has the connecting rod with the scraper blade rigid coupling, the connecting plate has the pivot of cup jointing with the sampling tube activity with the one end rigid coupling of keeping away from the scraper blade, the pivot stretches into the fixed cover of one end to the butt joint hole and has connect gear one, the bottom meshing of gear one has docking gear, docking gear's inner circle is fixed to be cup jointed the dwang that cup joints with the sampling tube activity, gear two that cup joints with the dwang is fixed to one side of docking gear is installed, one side meshing of gear two has the rack that sets up along butt joint hole length direction, the one end rigid coupling that the rack is close to the cavity has the slider that cup joints with the drive ring slip.
Preferably, the top of the driving ring is provided with an ascending guide groove, a maintaining guide groove and a descending guide groove which are sequentially arranged and have circular arc structures, the ascending guide groove is communicated with the maintaining guide groove and the descending guide groove, the maintaining guide groove is communicated with the descending guide groove, the cross sections of the ascending guide groove and the maintaining guide groove and the descending guide groove are all of T-shaped structures, the ascending guide groove, the maintaining guide groove and the descending guide groove are all in sliding sleeve connection with the sliding block, the sliding cross section is of a T-shaped structure, the ascending guide groove is arranged in an upward inclined mode, the descending guide groove is arranged in a downward inclined mode, and the ascending guide groove is communicated with the lowest end of the descending guide groove.
Preferably, the guide unit is including setting gradually to convex structure and the intercommunication press the guide way, stabilize the guide way, relax guide way and buffering guide way, press the downward setting of guide way slope, relax the upward setting of guide way slope, press the highest end of guide way and relax the highest end of guide way and all communicate with buffering guide way.
Preferably, pushing mechanism includes the closing plate with holding tank sliding connection, one side rigid coupling of closing plate have with the spring of holding tank inside wall rigid coupling, connecting channel is located the closing plate and keeps away from the one end of spring, closing plate and butt joint ring bottom and rigid coupling, butt joint ring bottom set up two sets of sealing washer mounting grooves rather than coaxial setting, and the holding tank distributes between two sets of sealing washer mounting grooves, the sealing washer mounting groove is fixed cup jointed the sealing washer that cup joints with cavity bottom inside wall slip, adopt latch draw-in groove mode joint between butt joint ring and the clamp plate.
Preferably, the conversion unit comprises a movable rod fixedly connected with the bottom of the driving ring, a movable pipe fixedly connected with the top of the pressing plate is movably sleeved at the bottom of the movable rod, a cross rod is fixedly sleeved on the outer ring of the top of the movable pipe, and the cross rod is slidably sleeved with the pressing guide groove, the stabilizing guide groove, the releasing guide groove and the buffering guide groove.
Preferably, the fixed gear circle that has cup jointed rather than coaxial setting in the bottom of drive ring, one side meshing of gear circle has the driving gear, and the fixed cover of driving gear inner circle has connect the drive shaft, and the motor with cavity inside wall rigid coupling is installed to the bottom of drive shaft, and the bottom of sampling tube has been seted up and has been got the material mouth, and the opening part of getting the material mouth articulates there is the apron, gets the both sides that material mouth and holding tank are located the sampling tube axis.
In the present invention,
through the sampling tube that sets up, accomodate sleeve pipe, slide, scraper, butt joint hole, docking mechanism, cavity, actuating mechanism, holding tank, pushing mechanism, interface channel, connect the feed cylinder and get the material mouth for this design is convenient to be sampled the cutting operation to the patient, and the in-process that takes out simultaneously after the sampling is accomplished reduces the discomfort that causes the patient, and the sample that conveniently will take is collected and is handled, makes things convenient for medical staff to carry out the sampling operation, improves sampling operating efficiency.
Drawings
FIG. 1 is a schematic structural diagram of a sampling and collecting system for tumor pharmacology research;
FIG. 2 is a schematic view of a locally enlarged structure of a sampling and collecting system A for facilitating pharmacological study of tumors according to the present invention;
FIG. 3 is a schematic view of a locally enlarged structure of a sample sampling and collecting system B for facilitating pharmacological study of tumors according to the present invention;
FIG. 4 is a schematic structural diagram of a pushing mechanism of a sampling and collecting system for facilitating pharmacological study of tumors according to the present invention;
FIG. 5 is a schematic structural diagram of a driving ring of a sampling and collecting system for tumor pharmacology research according to the present invention;
fig. 6 is a schematic structural diagram of a sample sampling and collecting system conversion unit convenient for tumor pharmacological research according to the present invention.
In the figure: the sampling tube sampling device comprises a sampling tube 1, a receiving sleeve 2, a slideway 3, a scraper 4, a butt joint hole 5, a butt joint mechanism 6, a cavity 7, a driving mechanism 8, a containing groove 9, a pushing mechanism 10, a connecting channel 11, a charging barrel 12, a material taking port 13, a lifting guide groove 32, a holding guide groove 33, a descending guide groove 34, a pressing guide groove 41, a stabilizing guide groove 42, a loosening guide groove 43, a buffering guide groove 44, a connecting plate 61, a connecting rod 62, a rotating shaft 63, a first gear 64, a butt joint gear 65, a rotating shaft 66, a second gear 67, a rack 68, a driving ring 81, a driving ring 82, a switching unit 83, a guiding unit 84, a pressing plate 85 and a butt joint ring 86.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Referring to fig. 1-6, a sample sampling and collecting system convenient for tumor pharmacological research comprises a sampling tube 1 with an opening at one end, a receiving sleeve 2 with an annular structure is fixedly sleeved on an inner ring at the opening of the sampling tube 1, a slideway 3 with an annular structure is arranged at one end of the receiving sleeve 2 close to the opening of the sampling tube 1, a scraper 4 with a semicircular structure is slidably sleeved on the slideway 3, butt-joint holes 5 positioned inside the sampling tube 1 are respectively arranged at two ends of the scraper 4, a butt-joint mechanism 6 fixedly connected with the end parts of the scraper 4 is arranged inside the butt-joint holes 5, a cavity 7 with the same annular structure is arranged between the bottoms of the two groups of butt-joint holes 5, the cavity 7 is positioned inside the sampling tube 1 and is coaxial with the sampling tube 1, a driving mechanism 8 is arranged inside the cavity 7, a containing groove 9 with an arc-shaped structure is arranged on the inner side wall of the bottom of the cavity 7, and a pushing mechanism 10 is slidably connected inside the containing groove 9, the bottom of holding tank 9 is seted up the connecting channel 11 that the U type is connected, and the other end of connecting channel 11 stretches out from sample tube 1 bottom inside wall, and the bottom of accomodating sleeve pipe 2 is installed and is connect the material section of thick bamboo 12 that cup joints with sample tube 1 slip.
Further, the driving mechanism 8 includes an annular driving ring 81 movably sleeved with the cavity 7, a driving ring 82 coaxially disposed on the top of the driving ring 81 is fixedly connected to the annular driving ring 82, the driving ring 82 is slidably connected to the docking mechanism 6, a converting unit 83 is fixedly connected to the bottom of the driving ring 81, a guiding unit 84 disposed on the inner side wall of the cavity 7 is disposed on one side of the converting unit 83, the guiding unit 84 is slidably connected to the converting unit 83, a pressing plate 85 coaxially disposed on the cavity 7 is fixedly connected to the bottom of the converting unit 83, and a docking ring 86 fixedly connected to the pushing mechanism 10 is clamped to the bottom of the pressing plate 85.
Particularly, the docking mechanism 6 includes connecting plates 61 of a circular structure located at two ends of the scraper 4 and slidably sleeved with the inner side wall of the sampling tube 1, one end of the connecting plate 61 close to the scraper 4 is fixedly connected with a connecting rod 62 fixedly connected with the scraper 4, one end of the connecting plate 61 far away from the scraper 4 is fixedly connected with a rotating shaft 63 movably sleeved with the sampling tube 1, one end of the rotating shaft 63 extending into the docking hole 5 is fixedly sleeved with a first gear 64, the bottom of the first gear 64 is engaged with a docking gear 65, an inner ring of the docking gear 65 is fixedly sleeved with a rotating rod 66 movably sleeved with the sampling tube 1, one side of the docking gear 65 is provided with a second gear 67 fixedly sleeved with the rotating rod 66, one side of the second gear 67 is engaged with a rack 68 arranged along the length direction of the docking hole 5, and one end of the rack 68 close to the cavity 7 is fixedly connected with a slider slidably sleeved with the driving ring 82.
Specifically, the top of the driving ring 82 is provided with an ascending guide groove 32, a maintaining guide groove 33 and a descending guide groove 34 which are sequentially arranged and have circular arc structures, the ascending guide groove 32 is communicated with the maintaining guide groove 33 and the descending guide groove 34, the maintaining guide groove 33 is communicated with the descending guide groove 34, the cross sections of the ascending guide groove 32, the maintaining guide groove 33 and the descending guide groove 34 are all of T-shaped structures, the ascending guide groove 32, the maintaining guide groove 33 and the descending guide groove 34 are all in sliding sleeve connection with a sliding block, the sliding cross section is of the T-shaped structure, the ascending guide groove 32 is obliquely arranged upwards, the descending guide groove 34 is obliquely downwards, and the opposite end of the ascending guide groove 32 is communicated with the lowest end of the descending guide groove 34.
It should be noted that the guiding unit 84 includes a pressing guide slot 41, a stabilizing guide slot 42, a relaxing guide slot 43 and a buffering guide slot 44 which are sequentially arranged in an arc-shaped structure and are communicated with each other, the pressing guide slot 41 is arranged obliquely downward, the relaxing guide slot 43 is arranged obliquely upward, and the highest end of the pressing guide slot 41 and the highest end of the relaxing guide slot 43 are communicated with the buffering guide slot 44.
In addition, pushing mechanism 10 includes the closing plate 101 with holding tank 9 sliding connection, one side rigid coupling of closing plate 101 has the spring 102 with holding tank 9 inside wall rigid coupling, connecting channel 11 is located the one end that closing plate 101 kept away from spring 102, closing plate 101 and butt joint ring 86 bottom and rigid coupling, butt joint ring 86 bottom is offered two sets of rather than the coaxial sealing washer mounting groove that sets up, and holding tank 9 distributes between two sets of sealing washer mounting grooves, the sealing washer mounting groove is fixed cup jointed the sealing washer that cup joints with cavity 7 bottom inside wall sliding, adopt latch draw-in groove mode joint between butt joint ring 86 and the clamp plate 85.
In addition, the conversion unit 83 includes a movable rod fixedly connected to the bottom of the driving ring 81, a movable tube fixedly connected to the top of the pressing plate 85 is movably sleeved on the bottom of the movable rod, a cross rod is fixedly sleeved on the outer ring of the top of the movable tube, and the cross rod is slidably sleeved on the pressing guide groove 41, the stabilizing guide groove 42, the releasing guide groove 43 and the buffering guide groove 44.
It needs to explain, the fixed gear circle that has cup jointed rather than coaxial setting in the bottom of initiative ring 81, one side meshing of gear circle has the driving gear, the fixed cover of driving gear inner circle has connect the drive shaft, the motor with 7 inside wall rigid couplings of cavity is installed to the bottom of drive shaft, the bottom of sampling tube 1 has been seted up and has been got material mouth 13, the opening part of getting material mouth 13 articulates there is the apron, it is located the both sides of sampling tube 1 axis to get material mouth 13 and holding tank 9.
The working principle is as follows: when the sampling tube is used, the sampling tube 1 is held by hand to stretch the sampling tube 1 to a tumor position from a wound, when sampling is needed, a motor positioned at the bottom of a driving ring 81 is started, then the motor drives a driving shaft to rotate, so that a driving gear drives a gear ring to rotate, so that the driving ring 81 rotates, a driving ring 82 positioned at the top of the driving ring 81 and a conversion unit 83 positioned at the bottom of the driving ring 81 rotate together, when the driving ring 82 rotates, a slide block in sliding connection with the driving ring starts to be pushed upwards by an ascending guide groove 32, at the moment, the slide block drives a rack 68 to move upwards, when the rack 68 moves upwards, a gear II 67 is driven to rotate, so that a first gear 64 is driven by a butting gear 65 to rotate, so that a rotating shaft 63 rotates, at the moment, a scraper 4 cuts the tumor when rotating, and meanwhile, the scraper 4 with an inwards-recessed semicircular structure contains the cut tumor therein, then the slide block moves to the position of the retaining guide groove 33 along the ascending guide groove 32, in the process, the scraper 4 is positioned in the sampling tube 1 from the beginning and is abutted with the slideway 3 to rotate 180 degrees, so that the opening of the scraper 4 faces the slideway 3, a sample scraped away by the scraper 4 is positioned between the scraper 4 and the slideway 3, the outer convex surface of the rotated scraper 4 is abutted with the tumor, the scraper 4 is blocked at the opening of the sampling tube 1 in the direction, then the active ring 81 continues to rotate along with the continuous rotation of the motor, at the moment, the slide block continues to move along the retaining guide groove 33, so that the rack 68 does not move up and down;
when the driving ring 81 moves, the cross bar on the conversion unit 83 starts to move along the buffering guide groove 41, when the slide block moves along the retaining guide groove 33 after the scraper 4 cuts the tumor, the cross bar moves from the buffering guide groove 41 to the pressing guide groove 41, at this time, the cross bar moves downward under the action of the pressing guide groove 41, so that the pressing plate 85 is clamped with the docking ring 86 downward, at this time, along with the rotation of the driving ring 81, the driving ring 81 drives the movable rod and the movable tube to move, so that the pressing plate 85 drives the docking ring 86 clamped with the pressing plate 85 to move, at this time, the sealing plate 101 at the bottom of the docking ring 86 moves towards the direction of the spring 102, so that the gas inside the sampling tube 1 moves towards the inside of the accommodating groove 9 along the connecting channel 11, so that the pressure inside the sampling tube 1 becomes small, the sample above the slide way 3 falls downwards into the receiving tube 12, and then the operator takes out the sampling tube 1, open the apron that is located to get material mouth 13 and will connect the sample on the feed cylinder 12 to take out, when taking out because the evagination face and the tumour of scraper blade 4 contradict, avoid taking out the in-process with the outside absorption of tumour position, reduce the damage to the patient when taking out, this design is convenient to be sampled the cutting operation to the patient, the in-process of taking out simultaneously after the sampling is accomplished reduces the discomfort that causes the patient, the sample of conveniently taking is collected and is handled, make things convenient for medical staff to carry out the sampling operation, improve sampling operating efficiency.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the equipment or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (8)
1. A sample sampling and collecting system convenient for tumor pharmacological research comprises a sampling tube (1) with one end provided with an opening, and is characterized in that an inner ring at the opening of the sampling tube (1) is fixedly sleeved with a receiving sleeve (2) with an annular structure, one end of the receiving sleeve (2) close to the opening of the sampling tube (1) starts to be provided with a slideway (3) with an annular structure, the slideway (3) is slidably sleeved with a scraper (4) with a semicircular structure, butt joint holes (5) positioned in the sampling tube (1) are respectively arranged at two ends of the scraper (4), a butt joint mechanism (6) fixedly connected with the end part of the scraper (4) is arranged in each butt joint hole (5), a cavity (7) with the same annular structure is arranged between the bottoms of the two groups of butt joint holes (5), and the cavity (7) is positioned in the sampling tube (1) and is coaxial with the sampling tube (1), the internally mounted of cavity (7) has actuating mechanism (8), holding tank (9) along circular arc structure are seted up to the bottom inside wall of cavity (7), the inside sliding connection of holding tank (9) has pushing mechanism (10), connect channel (11) that the U type is connected are seted up to the bottom of holding tank (9), and the other end of connect channel (11) stretches out from sampling pipe (1) bottom inside wall, and the bottom of accomodating sleeve pipe (2) is installed and is connect feed cylinder (12) that cup joints with sampling pipe (1) slip.
2. The system for sampling and collecting samples for tumor pharmacology research according to claim 1, it is characterized in that the driving mechanism (8) comprises an annular driving ring (81) movably sleeved with the cavity (7), the top of the driving ring (81) is fixedly connected with a driving ring (82) which is coaxially arranged with the driving ring and has an annular structure, the driving ring (82) is connected with the butt joint mechanism (6) in a sliding way, the bottom of the driving ring (81) is fixedly connected with a conversion unit (83), one side of the conversion unit (83) is provided with a guide unit (84) positioned on the inner side wall of the cavity (7), and the guide unit (84) is connected with the conversion unit (83) in a sliding manner, the bottom of the conversion unit (83) is fixedly connected with a pressure plate (85) which is coaxially arranged with the cavity (7) and has an annular structure, and the bottom of the pressure plate (85) is clamped with a butt joint ring (86) fixedly connected with the pushing mechanism (10).
3. The system for sampling and collecting samples convenient for tumor pharmacological research according to claim 1, wherein the docking mechanism (6) comprises connecting plates (61) of a circular structure which are located at two ends of the scraper (4) and are slidably sleeved with the inner side wall of the sampling tube (1), one end of the connecting plate (61) close to the scraper (4) is fixedly connected with a connecting rod (62) fixedly connected with the scraper (4), one end of the connecting plate (61) far away from the scraper (4) is fixedly connected with a rotating shaft (63) movably sleeved with the sampling tube (1), one end of the rotating shaft (63) extending into the docking hole (5) is fixedly sleeved with a first gear (64), the bottom of the first gear (64) is engaged with a docking gear (65), a rotating rod (66) movably sleeved with the inner ring (1) of the sampling tube is fixedly sleeved with the docking gear (65), one side of the docking gear (65) is provided with a second gear (67) fixedly sleeved with the rotating rod (66), one side of the second gear (67) is engaged with a rack (68) arranged along the length direction of the butt joint hole (5), and one end of the rack (68) close to the cavity (7) is fixedly connected with a slide block which is in sliding sleeve joint with the driving ring (82).
4. The system for sampling and collecting samples for tumor pharmacology research according to claim 1, the novel lifting guide ring is characterized in that an ascending guide groove (32), a maintaining guide groove (33) and a descending guide groove (34) which are of circular arc structures and are sequentially arranged are formed in the top of the driving ring (82), the ascending guide groove (32) is communicated with the maintaining guide groove (33) and the descending guide groove (34), the maintaining guide groove (33) is communicated with the descending guide groove (34), the cross sections of the ascending guide groove (32), the maintaining guide groove (33) and the descending guide groove (34) are all T-shaped structures, the ascending guide groove (32), the maintaining guide groove (33) and the descending guide groove (34) are all in sliding sleeve connection with a sliding block, the sliding cross section is of the T-shaped structure, the ascending guide groove (32) is arranged in an upward inclined mode, the descending guide groove (34) is arranged in a downward inclined mode, and the opposite low end of the ascending guide groove (32) is communicated with the lowest end of the descending guide groove (34).
5. The system for sampling and collecting samples convenient for tumor pharmacological research according to claim 1, wherein the guiding unit (84) comprises a pressing guiding groove (41), a stabilizing guiding groove (42), a relaxing guiding groove (43) and a buffering guiding groove (44) which are sequentially arranged in a circular arc structure and communicated, the pressing guiding groove (41) is obliquely arranged downwards, the relaxing guiding groove (43) is obliquely arranged upwards, and the highest end of the pressing guiding groove (41) and the highest end of the relaxing guiding groove (43) are communicated with the buffering guiding groove (44).
6. The system for sampling and collecting samples convenient for tumor pharmacological research according to claim 1, wherein the pushing mechanism (10) comprises a sealing plate (101) slidably connected to the accommodating groove (9), a spring (102) fixedly connected to an inner side wall of the accommodating groove (9) is fixedly connected to one side of the sealing plate (101), the connecting channel (11) is located at one end of the sealing plate (101) far away from the spring (102), the sealing plate (101) is fixedly connected to a bottom of the docking ring (86), two sets of sealing ring mounting grooves coaxially arranged with the docking ring (86) are formed in the bottom of the docking ring (86), the accommodating groove (9) is distributed between the two sets of sealing ring mounting grooves, the sealing ring mounting grooves are fixedly sleeved with sealing rings slidably sleeved to an inner side wall of the bottom of the cavity (7), and the docking ring (86) is clamped to the pressing plate (85) in a clamping groove manner by using a clamping tooth.
7. The system for sampling and collecting samples convenient for tumor pharmacological research according to claim 2, wherein the conversion unit (83) comprises a movable rod fixedly connected with the bottom of the active ring (81), a movable tube fixedly connected with the top of the pressing plate (85) is movably sleeved at the bottom of the movable rod, a cross rod is fixedly sleeved on the outer ring at the top of the movable tube, and the cross rod is slidably sleeved with the pressing guide groove (41), the stabilizing guide groove (42), the releasing guide groove (43) and the buffering guide groove (44).
8. The system for sampling and collecting samples convenient for tumor pharmacological research according to claim 1, wherein a gear ring coaxially arranged with the driving ring (81) is fixedly sleeved at the bottom of the driving ring, a driving gear is meshed at one side of the gear ring, a driving shaft is fixedly sleeved at the inner ring of the driving gear, a motor fixedly connected with the inner side wall of the cavity (7) is installed at the bottom of the driving shaft, a material taking opening (13) is formed in the bottom of the sampling tube (1), a cover plate is hinged to an opening of the material taking opening (13), and the material taking opening (13) and the accommodating groove (9) are located at two sides of the axis of the sampling tube (1).
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| CN202110067360.3A CN113662591B (en) | 2021-01-19 | 2021-01-19 | Sample sampling and collecting system convenient for pharmacological research of tumors |
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| CN202110067360.3A CN113662591B (en) | 2021-01-19 | 2021-01-19 | Sample sampling and collecting system convenient for pharmacological research of tumors |
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Citations (7)
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|---|---|---|---|---|
| GB2120207A (en) * | 1982-04-27 | 1983-11-30 | Cocksedge And Company Limited | Sampling apparatus |
| US20140142602A1 (en) * | 2012-11-20 | 2014-05-22 | Oscar Polo | Core Biopsy Scissors |
| CN206586975U (en) * | 2016-10-12 | 2017-10-27 | 刘兰英 | Internal Medicine-Oncology sampler |
| CN109668755A (en) * | 2018-12-26 | 2019-04-23 | 胡少军 | A kind of device for extracting breast tumor tissues |
| CN109700483A (en) * | 2018-12-13 | 2019-05-03 | 和光宇 | A kind of sampling device for biopsy of tumour department |
| CN109938779A (en) * | 2019-03-20 | 2019-06-28 | 南阳市中心医院 | A kind of Internal Medicine-Oncology puncture sampler |
| CN111803134A (en) * | 2020-07-20 | 2020-10-23 | 蚌埠医学院 | Multifunctional oral microorganism sampling box |
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2021
- 2021-01-19 CN CN202110067360.3A patent/CN113662591B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2120207A (en) * | 1982-04-27 | 1983-11-30 | Cocksedge And Company Limited | Sampling apparatus |
| US20140142602A1 (en) * | 2012-11-20 | 2014-05-22 | Oscar Polo | Core Biopsy Scissors |
| CN206586975U (en) * | 2016-10-12 | 2017-10-27 | 刘兰英 | Internal Medicine-Oncology sampler |
| CN109700483A (en) * | 2018-12-13 | 2019-05-03 | 和光宇 | A kind of sampling device for biopsy of tumour department |
| CN109668755A (en) * | 2018-12-26 | 2019-04-23 | 胡少军 | A kind of device for extracting breast tumor tissues |
| CN109938779A (en) * | 2019-03-20 | 2019-06-28 | 南阳市中心医院 | A kind of Internal Medicine-Oncology puncture sampler |
| CN111803134A (en) * | 2020-07-20 | 2020-10-23 | 蚌埠医学院 | Multifunctional oral microorganism sampling box |
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| Publication number | Publication date |
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| CN113662591B (en) | 2024-04-19 |
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