CN113640721B - Sample bidirectional conveying device and method for low-field nuclear magnetic resonance spectrometer - Google Patents
Sample bidirectional conveying device and method for low-field nuclear magnetic resonance spectrometer Download PDFInfo
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- CN113640721B CN113640721B CN202110961951.5A CN202110961951A CN113640721B CN 113640721 B CN113640721 B CN 113640721B CN 202110961951 A CN202110961951 A CN 202110961951A CN 113640721 B CN113640721 B CN 113640721B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
- G01R33/307—Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract
The invention belongs to the field of sample transmission of low-field nuclear magnetic resonance, and particularly discloses a sample bidirectional transmission device and method for a low-field nuclear magnetic resonance spectrometer. The device comprises a first sample feeding system, a second sample feeding system and a detection system, wherein the first sample feeding system comprises a first inner sample feeding pipe, a first pneumatic sample feeding module driver, a first sample capsule and a first polarized magnet, the second inner sample feeding pipe comprises a second pneumatic sample feeding module, a second sample capsule and a diode magnet, and the detection system comprises an outer sample feeding pipe and a weak magnetic detection sensor. The method comprises loading of a sample, pre-polarization of the sample, and signal acquisition and detection. The invention has simple structure and convenient operation, adopts high-temperature resistant materials, a multilayer heat insulation method and a high-performance damping technology, is suitable for carrying out the bidirectional transmission of the magnetic resonance sample based on an atomic magnetometer method, can be applied to the static magnetic field measurement based on low-field magnetic resonance, and can be also expanded to the detection of gaseous nuclear magnetic samples.
Description
Technical Field
The invention belongs to the field of sample transmission of low-field nuclear magnetic resonance, and particularly relates to a sample bidirectional transmission device and method for a low-field nuclear magnetic resonance spectrometer.
Background
The pneumatic method is a general method for transmitting nuclear magnetic samples in a traditional high-field magnetic resonance spectrometer, the nuclear magnetic samples are transmitted to a detection area of the high-field spectrometer by pneumatic, the polarization of the nuclear magnetic samples and the detection of magnetic resonance signals are completed in the same area in a superconducting magnet, and the nuclear magnetic samples are replaced and taken out by pushing out the detection area by pneumatic. In the low-field magnetic resonance research process, the pre-polarized region and the detection region are required to be spatially separated, the nuclear magnetic sample is required to be stably and rapidly conveyed between the pre-polarized region and the detection region for a plurality of times so as to reduce the loss of the polarization degree in the conveying process, the constant temperature of the nuclear magnetic sample is required, and the influence caused by the temperature change of the sample is reduced as much as possible.
At present, there are various sample transmission schemes for solving the problem of spectrometer devices in high-field and low-field magnetic resonance research, and the technical schemes of some related articles and patents are as follows: the patent US8212559 discloses "NMR-MAS probehead WITH INTEGRAL transport conduit for an MAS-rotor", which describes a conventional high-field spectrometer in which a nuclear magnetic sample tube loaded with a sample is stably transported to a detection region of the NMR spectrometer by an air flow in a transport pipe, and the sample is discharged by simply reversing the air flow to blow out the nuclear magnetic sample tube from the detection region. Biancalana V et al, in "A fast pneumatic sample-shuttle with attenuated shocks," use special openings in the sample tube and sample slide to alter the internal air flow to reduce vibration of the nuclear magnetic sample tube during delivery and sample introduction, but are not suitable for use in high temperature operating environments. In addition, chinese patent No. CN104807848B discloses a positioning and sampling method and apparatus for low-field magnetic resonance systems, which provides a means for directing and non-rotatably transferring nuclear magnetic sample tubes to a laser and atomic interaction detection region using the confinement of non-circular sample tubes.
In summary, the two nuclear magnetic samples cannot be effectively transferred to the detection region simultaneously without mixing by using the existing sample injection method or technology. In order to increase the types of simultaneous sample introduction of nuclear magnetic samples, improve the transmission efficiency of the nuclear magnetic samples, ensure the heat preservation performance of the nuclear magnetic samples and effectively expand functions, a brand new sample bidirectional transmission method and device for a low-field nuclear magnetic resonance spectrometer, which have no physical contact between a sample introduction pipe and a multi-layer magnetic shielding and weak magnetic detection sensor, are urgently required to be developed.
Disclosure of Invention
In order to meet the above defects or improvement demands of the prior art, the invention provides a sample bidirectional conveying device and a method for a low-field nuclear magnetic resonance spectrometer, which utilize the restraint function of an inner sample pipe to simultaneously and effectively convey two nuclear magnetic samples to a detection area near a sealing baffle plate under the condition of no mixing, so as to be conveniently applied to low-field magnetic resonance research; the ventilation pore canal is arranged between the two inner sampling pipes and the outer sampling pipe, the double-layer framework can realize effective heat insulation, and the part of the outer sampling pipe close to the detection area is coated with a high-temperature resistant heat insulation material, so that the heat insulation effect can be further improved, and the temperature of the sample capsule can be kept; the outer sampling tube is supported and clamped by the sampling tube on the side surface of the weak magnetic detection sensor, the outer sampling tube is in non-contact with the multilayer magnetic shielding and the weak magnetic detection sensor, and the damping sheet made of high-temperature silica gel or other elastic moderate high-temperature-resistant materials can effectively play a role in damping in the sample conveying process, so that introduced technical noise is reduced; the outer solenoid coil can effectively reduce the leakage magnetic field and reduce the influence of the leakage magnetic field on the weak magnetic detection sensor; the sample capsule is made of non-magnetic glass, can be fired by using a standard nuclear magnetic sample tube, is convenient to compare with magnetic resonance signals obtained by a traditional high-field spectrometer, and can be made of materials such as quartz or ceramic. The sample bidirectional conveying mode can be conveniently expanded to be used for gaseous nuclear magnetic samples through simple transformation.
In order to achieve the above object, according to one aspect of the present invention, there is provided a sample bidirectional transfer apparatus for a low-field nuclear magnetic resonance spectrometer, comprising a first sample transfer system, a second sample transfer system, and a detection system, wherein,
The first sample feeding system comprises a first inner sample feeding pipe, a first sample capsule driven by a first pneumatic sample feeding module is arranged in the first inner sample feeding pipe, and a sample feeding end of the first inner sample feeding pipe is provided with a first polarizing magnet for pre-polarizing a sample in the first sample capsule;
The second sample feeding system comprises a second inner sample feeding pipe, wherein the second inner sample feeding pipe and the first inner sample feeding pipe are symmetrically arranged, a second sample capsule driven by a second pneumatic sample feeding module is arranged in the second inner sample feeding pipe, and a second polarization magnet is arranged at the sample feeding end of the second inner sample feeding pipe and used for pre-polarizing samples in the second sample capsule;
The detection system comprises an outer sample feeding pipe and a weak magnetic detection sensor, wherein the sample feeding pipe is axially sleeved on the peripheries of the first inner sample feeding pipe and the second inner sample feeding pipe, an outer solenoid coil is arranged on the periphery of the sample feeding pipe and used for providing a precession magnetic field of a sample, a magnetic field coil is sleeved on the periphery of the outer solenoid coil, a plurality of layers of magnetic shielding layers are arranged on the periphery of the outer solenoid coil, a detection area of the sample is formed by the surrounding areas of the magnetic shielding layers, and the weak magnetic detection sensor is used for detecting NMR signals of weak magnetic field changes generated in the detection area of the sample.
As a further preferred mode, the inner wall of the middle part of the outer sample injection pipe is provided with a sealing partition plate, the first inner sample injection pipe and the sealing partition plate are arranged at intervals, the second inner sample injection pipe and the sealing partition plate are arranged at intervals, and the two ends of the outer sample injection pipe are provided with air outlets.
As a further preferable mode, a first damping piece and a second damping piece are respectively arranged on two side surfaces of the sealing partition plate, the first damping piece is arranged on one side close to the air outlet of the first inner sample injection pipe, and the second damping piece is arranged on one side close to the air outlet of the second inner sample injection pipe;
the first damping piece and the second damping piece are both made of high-temperature resistant elastic materials. If the first damping sheet and the second damping sheet are both prepared from high-temperature resistant silica gel, other soft high-temperature materials such as silicon aerogel with high density, graphene aerogel and other materials with moderate elasticity and high temperature resistance can be adopted.
As a further preferable mode, the first sample feeding system further comprises a first air duct and a first air sealing block, wherein the first air sealing block is used for sealing the sample feeding end of the first inner sample feeding pipe, one end of the first air duct is connected with the first air feeding module, and the other end of the first air duct penetrates through the first air sealing block and is communicated with the first inner sample feeding pipe;
The second sample feeding system further comprises a second airtight block and a second air duct, wherein the second airtight block is used for packaging the sample feeding end of the second inner sample feeding tube, one end of the second air duct is connected with the second pneumatic sample feeding module, and the other end of the second air duct penetrates through the second airtight block and is communicated with the second inner sample feeding tube.
As a further preferable mode, a first sample injection pipe support and a second sample injection pipe support are respectively arranged at the end parts of the two air outlets of the outer sample injection pipe, the first sample injection pipe support is arranged at one end close to the first polarized magnet, and the second sample injection pipe support is arranged at one end close to the second polarized magnet.
As a further preferred aspect, the detection system includes a first precision power supply, a second precision power supply, and a controller, wherein the first precision power supply is connected with the magnetic field coil, the second precision power supply is connected with the external solenoid coil, and the controller is in communication connection with the first pneumatic sample injection module, the second pneumatic sample injection module, the first precision power supply, the second precision power supply, and the weak magnetic detection sensor.
As a further preferred feature, the magnetic field coil is a three-axis helmholtz coil;
The first polarized magnet and the second polarized magnet are magnets with a sea shell array structure;
The multilayer magnetic shield is permalloy.
As a further preferable mode, the first pneumatic sample injection module and the second pneumatic sample injection module are identical in structure and comprise an air compressor, a vacuum pump, a first electromagnetic valve, a second electromagnetic valve and a pneumatic controller, wherein the air compressor is connected with one end of the first electromagnetic valve through a first pipeline, the other end of the first electromagnetic valve is communicated with one end of the second electromagnetic valve through a pipeline, the other end of the second electromagnetic valve is connected with the vacuum pump, and the first electromagnetic valve and the second electromagnetic valve are both in communication connection with the pneumatic controller.
According to another aspect of the present invention there is also provided a method for bi-directional transfer of a sample for a low field nuclear magnetic resonance spectrometer, comprising the steps of:
S1, sample loading: sealing a sample A into a first sample capsule, placing the first sample capsule filled with the sample A into a first inner sample inlet tube, sealing the sample inlet end of the first inner sample inlet tube, sealing a sample B into a second sample capsule, placing the second sample capsule filled with the sample B into a second inner sample inlet tube, and sealing the sample inlet end of the second sample capsule;
Pre-polarization of S2 sample: the first pneumatic sample injection module pneumatically drives the first sample capsule to the area where the first polarized magnet is located, so that the sample A stays in the area where the first polarized magnet is located for a preset time to realize the pre-polarization of the sample A, and meanwhile, the second pneumatic sample injection module pneumatically drives the second sample capsule to the area where the second polarized magnet is located, so that the sample B stays in the area where the second polarized magnet is located for a preset time to realize the pre-polarization of the sample B;
S3, signal acquisition and detection: the first pneumatic sample injection module drives the first sample capsule to a detection area in a pneumatic mode, the second pneumatic sample injection module drives the second sample capsule to the detection area in a pneumatic mode, meanwhile, the outer solenoid coil provides a precession magnetic field for the sample A and the sample B, the magnetic field coil sleeved on the periphery of the outer solenoid coil provides a corresponding magnetic field environment according to detection requirements, and the weak magnetic detection sensor detects NMR signals of weak magnetic field changes generated in the detection area by the sample A and the sample B simultaneously or respectively.
As a further preference, the method further comprises the steps of:
S4, sample replacement: starting a first pneumatic sample injection module, sucking a first sample capsule loaded with a sample A near the first air sealing block, taking down the first air sealing block, taking out or replacing the first sample capsule, starting a second pneumatic sample injection module, sucking a second sample capsule loaded with a sample B near the second air sealing block, taking down the second air sealing block, and taking out or replacing the second sample capsule.
In general, compared with the prior art, the above technical solution conceived by the present invention mainly has the following technical advantages:
1. The invention utilizes the restraint effect of the first inner sampling tube and the second inner sampling tube, can simultaneously and effectively transfer the sample capsules filled with two non-mixed nuclear magnetic samples to the detection area near the sealing partition plate, is convenient for simultaneously detecting the two non-mixed samples, can still be reused after the use of the samples, avoids waste, and can also respectively transfer the two sample capsules to the detection area.
2. The invention utilizes the restraint effect of the two inner sample injection pipes, and can also effectively transmit two mixed nuclear magnetic samples to a detection area near the sealing partition board at the same time to be applied to low-field magnetic resonance research.
3. According to the invention, the first inner sampling tube and the second inner sampling tube are inserted into the outer sampling tube made of high-temperature glass by adopting high-temperature resistant glass, and a ventilation duct is arranged between the inner sampling tube and the outer sampling tube, so that gas in the conveying process of a sample capsule can be circulated, effective heat insulation is realized, the sample capsule can effectively work in a self-selection exchange effect inhibition (SERF) atomic magnetometer, and the sample capsule can be conveniently used for a temperature change experiment of sample research.
4. The invention adopts the double-layer structure of the outer sample injection pipe and the inner sample injection pipe, can realize effective heat insulation, and the part of the outer sample injection pipe close to the detection area is coated with the high-temperature resistant heat insulation material to increase the heat preservation effect so as to maintain the temperature of the sample capsule, avoid the temperature change of the nuclear magnetic sample in the measuring process, and can be suitable for the nuclear magnetic sample temperature change experiment.
5. The side cover of the magnetic shielding is provided with holes to facilitate the placement of the sample feeding pipe, the first inner sample feeding pipe and the second inner sample feeding pipe which are inserted in the outer sample feeding pipe are arranged on the side surface of the weak magnetic detection sensor, the sample bidirectional conveying device is easy to use and improve, the sample replacement is convenient, the sample bidirectional conveying device can be conveniently applied to the research of gaseous nuclear magnetic samples through simple transformation, and the application is wider.
6. According to the invention, the outer sample feeding pipe is supported and clamped by the first sample feeding pipe and the second sample feeding pipe, and the outer sample feeding pipe is in non-contact with the multi-layer magnetic shielding and the weak magnetic detection sensor, so that the technical noise generated by vibration in sample transmission can be effectively reduced.
7. The magnetic field coil is a triaxial Helmholtz coil, can be used for further compensating residual static magnetic fields in magnetic shielding or generating a simulated static magnetic field when weak static magnetic field measurement based on magnetic resonance is carried out, and can be used for generating a pulse static magnetic field so as to control the spin state of a nuclear magnetic sample.
8. The first damping sheet and the second damping sheet fixed on the sealing partition plate are made of high-temperature-resistant and high-elasticity materials, such as high-temperature-resistant silica gel, so that the damping effect can be effectively achieved, and the introduced technical noise is reduced.
9. The compact outer solenoid coil is wound on the outer feed pipe, so that the leakage magnetic field can be effectively reduced, and the influence of the leakage magnetic field on the weak magnetic detection sensor is reduced.
10. The sample capsule is made of nonmagnetic glass or ceramic, and can be fired by using a standard nuclear magnetic sample tube, so that the stability of the sample material is effectively ensured, and the sample capsule is convenient to compare with magnetic resonance signals obtained by a traditional high-field spectrometer.
In summary, the sample bidirectional transfer device for the low-field nuclear magnetic resonance spectrometer provided by the invention has the following advantages:
The invention has the characteristics of capability of measuring various samples simultaneously, good heat insulation, high conveying speed, easy expansion and application, cost saving and the like. The invention adopts high temperature resistant material, advanced multilayer heat insulation method and high performance damping technology, which can further improve signal to noise ratio and signal detection sensitivity, has wide application prospect, and can more precisely measure nuclear magnetic sample NMR signal.
Drawings
FIG. 1 is a schematic diagram of a sample bi-directional transfer apparatus for a low field nuclear magnetic resonance spectrometer according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of another sample bi-directional transfer apparatus for a low field nuclear magnetic resonance spectrometer according to an embodiment of the present invention;
Fig. 3 is a schematic working diagram of a sample bidirectional transfer apparatus for a low-field nmr spectrometer according to an embodiment of the present invention, where [ a ] in fig. 3 is pre-polarization of a sample, [ B ] in fig. 3 is signal acquisition for applying a B-magnetic field, and [ C ] in fig. 3 is signal acquisition for applying a b+ magnetic field.
Like reference numerals denote like technical features throughout the drawings, in particular: 1-first air sealing block, 2-first inner sample tube, 3-first polarizing magnet, 4-first sample tube support, 5-outer solenoid coil, 6-outer sample tube, 7-multilayer magnetic shielding, 8-first nonmagnetic cover, 9-first sample capsule, 10-sealing partition, 11-second sample capsule, 12-second nonmagnetic cover, 13-magnetic field coil, 14-second sample tube support, 15-second polarizing magnet, 16-second inner sampling tube, 17-second airtight block, 18-first ventilation duct, 19-first damping piece, 20-second damping piece, 21-second ventilation duct, 31-first air duct, 32-second air duct, 33-first pneumatic sample injection module, 34-second pneumatic sample injection module, 41-first precise power supply, 42-weak magnetic detection sensor and 43-second precise power supply.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention. In addition, the technical features of the embodiments of the present invention described below may be combined with each other as long as they do not collide with each other.
As shown in fig. 1 and fig. 2, the sample bidirectional transfer apparatus for a low-field nuclear magnetic resonance spectrometer provided by the embodiment of the invention includes a first sample feeding system, a second sample feeding system and a detection system, wherein the first sample feeding system includes a first inner sample feeding tube 2, a first sample capsule 9 driven by a first pneumatic sample feeding module 33 is placed in the first inner sample feeding tube 2, and a sample feeding end of the first inner sample feeding tube 2 is provided with a first polarizing magnet 3 for pre-polarizing a sample in the first sample capsule 9. The second sample feeding system comprises a second inner sample feeding tube 16, the second inner sample feeding tube 16 and the first inner sample feeding tube 2 are symmetrically arranged, a second sample capsule 11 driven by a second pneumatic sample feeding module 34 is placed in the second inner sample feeding tube 16, and a second polarization magnet 15 is arranged at the sample feeding end of the second inner sample feeding tube 16 and used for pre-polarizing samples in the second sample capsule 11. The first polarized magnet 3 and the second polarized magnet 15 are magnets with a halbach array structure with holes in the middle, and the magnetic field strength is 2Tesla. The method is used for pre-polarization, and establishes thermal polarization degree for the nuclear magnetic sample in the nuclear magnetic sample tube. In the invention, the detection system comprises an outer sample feeding tube 6 and a weak magnetic detection sensor 42, the sample feeding tube 6 is axially sleeved on the outer circumferences of the first inner sample feeding tube 2 and the second inner sample feeding tube 16, an outer solenoid coil 5 is arranged on the outer circumference of the sample feeding tube 6 and is used for providing a feeding magnetic field of a sample, a magnetic field coil 13 is sleeved on the outer circumference of the outer solenoid coil 5, a multi-layer magnetic shielding 7 is arranged on the outer circumference of the outer solenoid coil 5, a detection area of the sample is formed by surrounding areas of the multi-layer magnetic shielding 7, and the weak magnetic detection sensor 42 is used for detecting NMR signals of weak magnetic field changes generated by the sample in the detection area.
More specifically, in the present invention, the first sample capsule 9 is sealed by the first nonmagnetic cover 8, and the second sample capsule 11 is sealed by the second nonmagnetic cover 12. The first sample capsule 9 and the second sample capsule 11 are made of non-magnetic glass or ceramic materials, and can be fired by using standard nuclear magnetic sample tubes, so that the stability of the sample materials is effectively ensured, and the comparison of the magnetic resonance signals obtained by the traditional high-field spectrometer is convenient.
A sealing partition board 10 is arranged on the inner wall of the middle part of the sample feeding pipe 6, and the sealing partition board 10 axially divides the sample feeding pipe 6 into two uniform and symmetrical unidirectional pipes. The first inner sample tube 2 is inserted into one end of the sample tube 6, the second inner sample tube 16 is inserted into the other end of the sample tube 6, and the first inner sample tube 2 and the second inner sample tube 16 are symmetrically arranged. The first inner sample injection tube 2 and the sealing partition plate 10 are arranged at intervals, the second inner sample injection tube 16 and the sealing partition plate 10 are arranged at intervals, air outlets are formed at two ends of the outer sample injection tube 6, in this way, a first ventilation duct 18 is formed between the inner wall of the outer sample injection tube 6 and the outer wall of the first inner sample injection tube 2, and a second ventilation duct 21 is formed between the inner wall of the outer sample injection tube 6 and the outer wall of the second inner sample injection tube 16. In the invention, the first inner sample feeding pipe and the second inner sample feeding pipe are made of high-temperature resistant glass, the two inner sample feeding pipes are inserted into the outer sample feeding pipe made of high-temperature glass, a ventilation duct is arranged between the inner sample feeding pipe and the outer sample feeding pipe, so that gas in the conveying process of the sample capsule can be fed in and fed out, effective heat insulation is realized, and the device can effectively work in a self-selection exchange effect inhibition (SERF) atomic magnetometer. Simultaneously, by utilizing the restraining action of the first inner sampling tube and the second inner sampling tube, the sample capsules filled with two non-mixed nuclear magnetic samples can be simultaneously and effectively conveyed to a detection area near the sealing partition plate, so that the two non-mixed samples can be conveniently and simultaneously detected, the samples can still be reused after being used, waste is avoided, and the two sample capsules can also be respectively conveyed to the detection area.
The first sample feeding system further comprises a first air duct 31 and a first air sealing block 1, wherein the first air sealing block 1 is used for packaging the sample feeding end of the first inner sample feeding pipe 2, one end of the first air duct 31 is connected with the first pneumatic sample feeding module 33, and the other end of the first air duct passes through the first air sealing block 1 and is communicated with the first inner sample feeding pipe 2. The second sample feeding system further comprises a second airtight block 17 and a second air duct 32, wherein the second airtight block 17 is used for packaging the sample feeding end of the second inner sample feeding tube 16, one end of the second air duct 32 is connected with the second pneumatic sample feeding module 34, and the other end of the second air duct passes through the second airtight block 17 and is communicated with the second inner sample feeding tube 16. In the present invention, the first air duct 31 and the second air duct 32 are made of teflon or a common soft plastic tube. For the gas circuit to provide a high pressure gas outflow channel.
In a preferred embodiment of the present invention, the sealing separator 10 is provided with a first shock absorbing sheet 19 and a second shock absorbing sheet 20 on both sides thereof, respectively, and the first shock absorbing sheet 19 and the second shock absorbing sheet 20 are adhered to the sealing separator 10 using a high temperature adhesive. The first damping plate 19 is disposed at a side close to the air outlet of the first inner sample injection tube 2, and the second damping plate 20 is disposed at a side close to the air outlet of the second inner sample injection tube 16. The first damping sheet 19 and the second damping sheet 20 are both made of high-temperature resistant elastic materials. For example, high-temperature resistant silica gel, other soft high-temperature materials such as silicon aerogel with high density, graphene aerogel and other materials with moderate elasticity and high temperature resistance can be adopted. During sample detection, the first sample capsule 9 may resist resting on the first shock absorbing sheet 19, i.e., stationary in the detection zone for a specified period of time, while the second sample capsule 11 may resist resting on the second shock absorbing sheet 20, stationary in the detection zone for a specified period of time, during operation of the first pneumatic sample injection module 33 and/or the second pneumatic sample injection module 34. The damping piece can effectively play a role in damping and reduce the introduced technical noise. Of course, other shock absorbing sheets that do not interfere with the magnetic field environment are also suitable for use in the present invention.
In the invention, the two air outlet end parts of the outer sample tube 6 are respectively provided with a first sample tube support 4 and a second sample tube support 14, the first sample tube support 4 is arranged at one end close to the first polarized magnet 3, and the second sample tube support 14 is arranged at one end close to the second polarized magnet 15. Meanwhile, one end of the outer solenoid coil 5 is fixed on the first sample injection pipe support, and the other end of the outer solenoid coil is fixed on the second sample injection pipe support.
The detection system comprises a first precise power supply 41, a second precise power supply 42 and a controller, wherein the first precise power supply 41 is connected with the magnetic field coil 13, the second precise power supply 42 is connected with the outer solenoid coil 5, and the controller is in communication connection with the first pneumatic sample injection module 33, the second pneumatic sample injection module 34, the first precise power supply 41, the second precise power supply 42 and the weak magnetic detection sensor 42. The first pneumatic sample injection module 33 and the second pneumatic sample injection module 34 have the same structure and comprise an air compressor, a vacuum pump, a first electromagnetic valve, a second electromagnetic valve and a pneumatic controller, wherein the air compressor is connected with one end of the first electromagnetic valve through a first pipeline, the other end of the first electromagnetic valve is communicated with one end of the second electromagnetic valve through a pipeline, the other end of the second electromagnetic valve is connected with the vacuum pump, and the first electromagnetic valve and the second electromagnetic valve are both in communication connection with the pneumatic controller. The device of the invention provides the power required by the movement of the sample by the gas, the pneumatic sample injection module controls the gas to enter and exit the inner sample inlet pipe, and controls the rapid and precise transmission of the sample capsule between the permanent magnet and the multi-layer magnetic shielding. In the implementation process, the first precise power supply 41, the weak magnetic detection sensor 42 and the second precise power supply 43 provide the required bidirectional sample transmission magnetic detection function so as to further realize the low-field nuclear magnetic resonance detection function.
In the preferred embodiment of the present invention, the multi-layer magnetic shield 7 is made of permalloy, and shields stray magnetic fields, etc., and provides a low magnetic field environment for nuclear magnetic sample detection.
When the device works, the computer drives the first sample capsule 9 and the second sample capsule 11 to slide in the first inner sample injection tube 2 and the second inner sample injection tube 16 respectively through the on-off state of the first pneumatic sample injection module 33 and the second pneumatic sample injection module 34, so that the positioning and the transmission of the nuclear magnetic sample between the central positions of the polarized magnet multilayer magnetic shielding 7 are realized. Connecting the pneumatic sample injection module with the first inner sample injection tube and the second inner sample injection tube by utilizing a gas guide tube; the sealing partition board 10 is used for controlling the sample capsule to reach the center of the multi-layer magnetic shielding, and effectively reducing the vibration of the sample injection device, so that the signal-to-noise ratio of the nuclear magnetic detection sample signal is improved. In practice, the NMR signals of the weak magnetic field changes generated by the nuclear magnetic sample in the shielding box are measured by the weak magnetic detection sensor 42. Compared with the existing sample injection device, the device provided by the invention realizes bidirectional sample transmission and effective heat preservation of nuclear magnetic samples.
According to another aspect of the present invention, there is also provided a sample bidirectional transfer method for a low-field nuclear magnetic resonance spectrometer, which specifically includes the steps of:
a) Sample loading: the nuclear magnetic sample A to be measured is filled into a first sample capsule 9 and sealed by a first nonmagnetic sealing cover 8, then the first air sealing block 1 on the first inner sample feeding tube 2 is taken down, the first sample capsule 9 filled with the sample is placed into the first inner sample feeding tube 2, and the first air sealing block 1 is returned. And filling the nuclear magnetic sample B to be measured into a second sample capsule 11, sealing by a second nonmagnetic sealing cover 12, then taking down a first air sealing block 17 on a second inner sample injection tube 16, and putting the second sample capsule 11 filled with the sample into the second inner sample injection tube 16, wherein the nuclear magnetic sample is completely loaded.
B) Pre-polarization of the sample: the first pneumatic sample injection module 33 controls the first sample capsule 9 filled with the nuclear magnetic sample A to be detected to stay in the area of the first polarizing magnet 3 for a period of time, so as to pre-polarize the nuclear magnetic sample. The second pneumatic sample injection module 34 controls the second sample capsule 11 of the nuclear magnetic sample B to be detected to stay in the area of the first polarizing magnet 15 for a period of time for pre-polarizing the nuclear magnetic sample. While the outer solenoid coil 5 is turned on to apply a precession magnetic field.
C) Signal acquisition and detection: the first pneumatic sample injection module 33 operates to blow the first sample capsule 9 containing the sample a to be measured along the first inner sample injection tube 2 into the detection zone in the multilayer magnetic shield 7 by means of an air flow, and to stay and be measured. The second pneumatic sample injection module 34 operates to blow the second sample capsule 11 containing the sample B to be measured into the detection zone in the multilayer magnetic shield 7 along the second inner sample injection tube 16 by means of an air flow, and to stay and be measured. The first pneumatic sample injection module 33 and the second pneumatic sample injection module 34 can be operated simultaneously to transport the two samples to the detection position to measure the signal of the AB sample simultaneously, or can be operated separately to transport the two samples to the detection position to measure the A sample first and then the B sample or to measure the B sample first and then the A sample.
D) Unloading and replacement of samples: the first pneumatic sample injection module 33 is started, the first sample capsule 9 loaded with the nuclear magnetic sample is sucked near the first air sealing block 1, the sealing block is taken down to be airtight, then the first non-magnetic sealing cover 8 is clamped by tweezers, the first sample capsule 9 is taken out, and the nuclear first sample capsule 1 is directly unloaded or replaced. The second pneumatic sample injection module 34 is started, the second sample capsule 11 loaded with the nuclear magnetic sample is sucked near the second airtight block 17, the sealing block is taken down to be airtight, then the second non-magnetic sealing cover 12 is clamped by forceps, the second sample capsule 11 is taken out, and the nuclear second sample capsule 11 is directly unloaded or replaced.
According to the invention, the sample capsules filled with two non-mixed nuclear magnetic samples can be effectively conveyed to the detection area near the sealing partition plate simultaneously or respectively, and the two non-mixed samples are detected simultaneously, so that the samples can be reused after being used, and waste is avoided; the ventilation pore canal is arranged between the two inner sampling pipes and the outer sampling pipe, the double-layer framework can realize effective heat insulation, the temperature change of the nuclear magnetic sample in the measuring process is avoided, and the nuclear magnetic sample temperature changing experiment is applicable to the nuclear magnetic sample temperature changing experiment; the outer sampling tube is in non-contact with the multi-layer magnetic shielding and the weak magnetic detection sensor, so that technical noise generated by vibration in sample transmission can be effectively reduced; the invention has simple structure and convenient operation, adopts high-temperature resistant materials, an advanced multilayer heat insulation method and a high-performance damping technology, is suitable for the bidirectional transmission of the magnetic resonance sample based on an atomic magnetometer method, can be applied to the static magnetic field measurement based on low-field magnetic resonance, and can be further expanded for the detection of gaseous nuclear magnetic samples.
Example 1
In this embodiment, the device is composed of a first air sealing block 1, a first inner sample tube 2, a first polarizing magnet 3, a first sample tube support 4, an outer solenoid coil 5, an outer sample tube 6, a multi-layer magnetic shield 7, a first nonmagnetic cover 8, a first sample capsule 9, a sealing partition plate 10, a second sample capsule 11, a second nonmagnetic cover 12, a magnetic field coil 13, a second sample tube support 14, a second polarizing magnet 15, a second inner sample tube 16, a second air sealing block 17, a first ventilation duct 18, a first damper sheet 19, a second damper sheet 20, a second ventilation duct 21, a first pneumatic sample module 33 and a second pneumatic sample module 34. The first pneumatic sample injection module 33 and the second pneumatic sample injection module 34 comprise oil-free piston air compressors with the model number of DW35, circulating water type multipurpose vacuum pumps with the model number of SHB-III, desk computers with the model number of THINKCENTRE E73, electromagnetic valves with the model numbers of ZS05-K and ZS05, and the first sample capsule 9 and the second sample capsule 11 are controlled to slide in the first inner sample injection pipe 2 and the second inner sample injection pipe 16. In this embodiment, some devices including the first precision power source 41, the weak magnetic detection sensor 42, and the second precision power source 43 need to be added, so that the device for detecting low-field magnetic resonance is more practical. Wherein the low-field detection sensor 42 may be a SQUID probe, miniaturized atomic magnetometer, induction coil, or the like, magnetic field sensor for low-field magnetic resonance.
As shown in fig. 3, in this embodiment, when the sample bidirectional transfer apparatus for a low-field nmr spectrometer works, the computer drives the first sample capsule 9 and the second sample capsule 11 to slide in the first inner sample tube 2 and the second inner sample tube 16 respectively through the on-off state of the first pneumatic sample injection module 33 and the second pneumatic sample injection module 34, so as to realize positioning transfer of the nuclear magnetic sample between the central positions of the polarized magnet multi-layer magnetic shielding 7. Connecting the pneumatic sample injection module with the first inner sample injection tube and the second inner sample injection tube by utilizing a gas guide tube; the sealing partition board 10 is used for controlling the sample capsule to reach the center of the multi-layer magnetic shielding, and effectively reducing the vibration of the sample injection device, so that the signal-to-noise ratio of the nuclear magnetic detection sample signal is improved. In practice, the NMR signals of the weak magnetic field changes generated by the nuclear magnetic sample in the shielding box are measured by the weak magnetic detection sensor 42.
It will be readily appreciated by those skilled in the art that the foregoing description is merely a preferred embodiment of the invention and is not intended to limit the invention, but any modifications, equivalents, improvements or alternatives falling within the spirit and principles of the invention are intended to be included within the scope of the invention.
Claims (8)
1. A sample bidirectional conveying device for a low-field nuclear magnetic resonance spectrometer is characterized by comprising a first sample conveying system, a second sample conveying system and a detection system, wherein,
The first sample feeding system comprises a first inner sample feeding pipe (2), a first sample capsule (9) driven by a first pneumatic sample feeding module (33) is arranged in the first inner sample feeding pipe (2), and a first polarizing magnet (3) is arranged at the sample feeding end of the first inner sample feeding pipe (2) and used for pre-polarizing samples in the first sample capsule (9);
the second sample feeding system comprises a second inner sample feeding pipe (16), the second inner sample feeding pipe (16) and the first inner sample feeding pipe (2) are symmetrically arranged, a second sample capsule (11) driven by a second pneumatic sample feeding module (34) is arranged in the second inner sample feeding pipe (16), and a second polarization magnet (15) is arranged at the sample feeding end of the second inner sample feeding pipe (16) and is used for pre-polarizing samples in the second sample capsule (11);
The detection system comprises an outer sample injection pipe (6) and a weak magnetic detection sensor (42), wherein the sample injection pipe (6) is axially sleeved on the peripheries of the first inner sample injection pipe (2) and the second inner sample injection pipe (16) and separates the first inner sample injection pipe (2) from the second inner sample injection pipe (16), an outer solenoid coil (5) is arranged on the periphery of the sample injection pipe (6) and is used for providing a precession magnetic field of a sample, a magnetic field coil (13) is sleeved on the periphery of the outer solenoid coil (5), a multilayer magnetic shielding (7) is arranged on the periphery of the outer solenoid coil (5), a detection area of the sample is formed by the surrounding area of the multilayer magnetic shielding (7), and the weak magnetic detection sensor (42) is used for detecting an NMR signal of weak magnetic field change generated in the detection area of the sample;
The inner wall of the middle part of the outer sampling tube (6) is provided with a sealing partition plate (10), the first inner sampling tube (2) and the sealing partition plate (10) are arranged at intervals, the second inner sampling tube (16) and the sealing partition plate (10) are arranged at intervals, two ends of the outer sampling tube (6) are provided with air outlets, in this way, a first ventilation duct (18) is formed between the inner wall of the outer sampling tube (6) and the outer wall of the first inner sampling tube (2), and a second ventilation duct (21) is formed between the inner wall of the outer sampling tube (6) and the outer wall of the second inner sampling tube (16);
the sealing partition plate (10) is used for controlling the sample capsule to reach the central position of the multi-layer magnetic shielding (7);
The two side surfaces of the sealing partition plate (10) are respectively provided with a first damping sheet (19) and a second damping sheet (20), the first damping sheet (19) is arranged at one side close to the air outlet of the first inner sample injection pipe (2), and the second damping sheet (20) is arranged at one side close to the air outlet of the second inner sample injection pipe (16);
The first damping sheet (19) and the second damping sheet (20) are both made of high-temperature resistant elastic materials.
2. The sample bidirectional conveying device for the low-field nuclear magnetic resonance spectrometer according to claim 1, wherein the first sample conveying system further comprises a first air duct (31) and a first air sealing block (1), the first air sealing block (1) is used for packaging a sample feeding end of the first inner sample feeding pipe (2), one end of the first air duct (31) is connected with the first pneumatic sample feeding module (33), and the other end of the first air duct passes through the first air sealing block (1) to be communicated with the first inner sample feeding pipe (2);
The second sample feeding system further comprises a second airtight block (17) and a second air guide pipe (32), wherein the second airtight block (17) is used for packaging the sample feeding end of the second inner sample feeding pipe (16), one end of the second air guide pipe (32) is connected with the second pneumatic sample feeding module (34), and the other end of the second air guide pipe passes through the second airtight block (17) and is communicated with the second inner sample feeding pipe (16).
3. The sample bidirectional transfer apparatus for a low-field nuclear magnetic resonance spectrometer according to claim 1, wherein a first sample tube support (4) and a second sample tube support (14) are respectively arranged at two air outlet ends of the outer sample tube (6), the first sample tube support (4) is arranged at one end close to the first polarizing magnet (3), and the second sample tube support (14) is arranged at one end close to the second polarizing magnet (15).
4. The sample bidirectional transfer apparatus for a low-field nuclear magnetic resonance spectrometer according to claim 1, wherein the detection system comprises a first precision power supply (41), a second precision power supply (43) and a controller, the first precision power supply (41) is connected with a magnetic field coil (13), the second precision power supply (43) is connected with the external solenoid coil (5), and the controller is in communication connection with the first pneumatic sample injection module (33), the second pneumatic sample injection module (34), the first precision power supply (41), the second precision power supply (43) and the weak magnetic detection sensor (42).
5. A sample bi-directional transfer apparatus for a low field nuclear magnetic resonance spectrometer according to claim 1, characterized in that the magnetic field coil (13) is a tri-axial helmholtz coil;
The first polarized magnet (3) and the second polarized magnet (15) are magnets with a sea shell array structure;
the multilayer magnetic shield (7) is permalloy.
6. The sample bidirectional conveying device for the low-field nuclear magnetic resonance spectrometer according to claim 1, wherein the first pneumatic sample injection module (33) and the second pneumatic sample injection module (34) have the same structure and comprise an air compressor, a vacuum pump, a first electromagnetic valve, a second electromagnetic valve and a pneumatic controller, wherein the air compressor is connected with one end of the first electromagnetic valve through a first pipeline, the other end of the first electromagnetic valve is communicated with one end of the second electromagnetic valve through a pipeline, the other end of the second electromagnetic valve is connected with a vacuum pump, and the first electromagnetic valve and the second electromagnetic valve are connected with the pneumatic controller in a communication mode.
7. A method for bidirectional transfer of samples for a low field nuclear magnetic resonance spectrometer, implemented with a sample bidirectional transfer device for a low field nuclear magnetic resonance spectrometer according to any one of claims 1-6, comprising the steps of:
S1, sample loading: sealing a sample A into a first sample capsule (9), placing the first sample capsule (9) filled with the sample A into a first inner sample injection tube (2), sealing the sample injection end of the first inner sample injection tube (2), sealing a sample B into a second sample capsule (11), placing the second sample capsule (11) filled with the sample B into a second inner sample injection tube (16), and sealing the sample injection end of the second sample capsule (11);
Pre-polarization of S2 sample: the first pneumatic sample injection module (33) drives the first sample capsule (9) to the area where the first polarized magnet (3) is located in a pneumatic mode, so that the sample A stays in the area where the first polarized magnet (3) is located for a preset time to realize the pre-polarization of the sample A, and meanwhile, the second pneumatic sample injection module (34) drives the second sample capsule (11) to the area where the second polarized magnet (15) is located in a pneumatic mode, so that the sample B stays in the area where the second polarized magnet (15) is located for a preset time to realize the pre-polarization of the sample B;
S3, signal acquisition and detection: the first pneumatic sample injection module (33) drives the first sample capsule (9) to a detection area in a pneumatic mode, the second pneumatic sample injection module (34) drives the second sample capsule (11) to the detection area in a pneumatic mode, meanwhile, the outer solenoid coil (5) provides a precession magnetic field for the sample A and the sample B, the magnetic field coil (13) sleeved on the periphery of the outer solenoid coil (5) provides a corresponding magnetic field environment according to detection requirements, and the weak magnetic detection sensor (42) simultaneously or respectively detects NMR signals of weak magnetic field changes generated by the sample A and the sample B in the detection area.
8. The method for bidirectional transfer of samples for a low field nuclear magnetic resonance spectrometer according to claim 7, further comprising the steps of:
S4, sample replacement: starting a first pneumatic sample injection module (33), sucking a first sample capsule (9) loaded with a sample A near the first air sealing block (1), taking down the first air sealing block (1), then taking out or replacing the first sample capsule (9), starting a second pneumatic sample injection module (34), sucking a second sample capsule (11) loaded with a sample B near the second air sealing block (17), taking down the second air sealing block (17), and then taking out or replacing the second sample capsule (11).
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| CN114184991A (en) * | 2021-11-22 | 2022-03-15 | 中国科学技术大学 | Ultra-low-field nuclear magnetic resonance spectrometer and measurement method |
| CN114660518A (en) * | 2022-03-18 | 2022-06-24 | 国仪量子(合肥)技术有限公司 | NMR equipment |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7187169B2 (en) * | 2004-11-03 | 2007-03-06 | The Regents Of The University Of California | NMR and MRI apparatus and method |
| US7880467B2 (en) * | 2005-06-09 | 2011-02-01 | Aspect Magnet Technologies Ltd. | Packed array of MRI/NMR devices and an MRI/NMR method of analyzing adjacent lines of goods simultaneously |
| JP5489797B2 (en) * | 2010-03-17 | 2014-05-14 | 三菱重工業株式会社 | Battery system |
| CN102519999B (en) * | 2011-11-11 | 2015-12-16 | 中国石油大学(北京) | Magnetic nuclear resonance analyzer and nuclear magnetic resonance measuring method |
| CN102830381B (en) * | 2012-08-15 | 2014-11-12 | 中国科学院武汉物理与数学研究所 | Nuclear magnetic resonance (NMR) device and measurement method based on laser atomic magnetometer |
| CN103383399A (en) * | 2013-07-25 | 2013-11-06 | 中国科学院武汉物理与数学研究所 | Air-operated sample feeding device for laser detection nuclear magnetic resonance (NMR) signal device |
| CN104807848B (en) * | 2015-05-15 | 2017-02-01 | 中国科学院武汉物理与数学研究所 | Device and method for positioning and sample feeding of low-field magnetism resonance system |
| US10818978B2 (en) * | 2016-05-13 | 2020-10-27 | Nio Usa, Inc. | Battery module having a pressure sensor |
| CN206583402U (en) * | 2017-03-06 | 2017-10-24 | 东莞前沿技术研究院 | A kind of deformation detecting device |
| CN107364720A (en) * | 2017-08-15 | 2017-11-21 | 厦门积硕科技有限公司 | A kind of twin flue transmitting-receiving work station, pneumatic sample Transmission system and control method |
| CN112723306B (en) * | 2020-12-17 | 2023-08-18 | 武汉光谷航天三江激光产业技术研究院有限公司 | Atomic air chamber manufacturing integrated bonding device and method for alkali metal direct filling |
| CN113100794A (en) * | 2021-03-26 | 2021-07-13 | 深圳市深图医学影像设备有限公司 | Method and device for removing motion artifacts of X-ray flat panel detector |
-
2021
- 2021-08-20 CN CN202110961951.5A patent/CN113640721B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103575586A (en) * | 2012-07-26 | 2014-02-12 | 梅特勒-托利多公开股份有限公司 | Sample divider |
Non-Patent Citations (1)
| Title |
|---|
| 基于原子磁力计的磁共振样品微弱磁场测量;王晓飞;中国博士学位论文全文数据库 工程科技Ⅱ辑(第02期);85-106 * |
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