CN113633338A - Micro-system for rapid pressure hemostasis drug delivery detection of large surface wound and implementation method - Google Patents
Micro-system for rapid pressure hemostasis drug delivery detection of large surface wound and implementation method Download PDFInfo
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- CN113633338A CN113633338A CN202110880765.9A CN202110880765A CN113633338A CN 113633338 A CN113633338 A CN 113633338A CN 202110880765 A CN202110880765 A CN 202110880765A CN 113633338 A CN113633338 A CN 113633338A
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- 230000023597 hemostasis Effects 0.000 title claims abstract description 57
- 238000001514 detection method Methods 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title claims abstract description 14
- 238000012377 drug delivery Methods 0.000 title claims description 21
- 239000003814 drug Substances 0.000 claims abstract description 69
- 206010052428 Wound Diseases 0.000 claims abstract description 52
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 52
- 229940079593 drug Drugs 0.000 claims abstract description 50
- 238000002955 isolation Methods 0.000 claims abstract description 32
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 20
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims abstract description 18
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 14
- 230000007246 mechanism Effects 0.000 claims abstract description 14
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 14
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 10
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 10
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 7
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 7
- 238000003825 pressing Methods 0.000 claims description 107
- 239000007788 liquid Substances 0.000 claims description 56
- 238000007789 sealing Methods 0.000 claims description 38
- 230000006835 compression Effects 0.000 claims description 16
- 238000007906 compression Methods 0.000 claims description 16
- 239000007787 solid Substances 0.000 claims description 8
- 210000004712 air sac Anatomy 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 3
- 239000004816 latex Substances 0.000 claims description 2
- 229920000126 latex Polymers 0.000 claims description 2
- 208000014674 injury Diseases 0.000 abstract description 6
- 230000008733 trauma Effects 0.000 abstract description 6
- 206010061218 Inflammation Diseases 0.000 abstract description 4
- 230000000740 bleeding effect Effects 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 230000035876 healing Effects 0.000 abstract description 4
- 230000004054 inflammatory process Effects 0.000 abstract description 4
- 230000008859 change Effects 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 2
- 239000010408 film Substances 0.000 abstract 3
- 238000001647 drug administration Methods 0.000 abstract 1
- 239000010409 thin film Substances 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 229920002799 BoPET Polymers 0.000 description 1
- 239000005041 Mylar™ Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000011369 optimal treatment Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/10—Wearable devices, e.g. garments, glasses or masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B2017/12004—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for haemostasis, for prevention of bleeding
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
本发明公开了一种表面大创伤快速压力止血给药检测微系统及实现方法。本发明包括：柔性PCB板、信号采集器、处理器、显示器、蓝牙模块、压力气囊隔离机构、小气囊、大气囊、温度传感器、薄膜压力传感器、释药薄膜、释药单元和生物兼容可溶性薄膜；本发明采用碳酸氢钠和硫酸铝反应产生二氧化碳进行自主加压止血，同时压力辅助释药机构在止血过程中能够释放药物，不仅能够加快止血速度且可附加杀菌消毒的功效；此外，本发明设置有薄膜压力传感器和温度传感器，实时监测压力与伤口表面的温度，确保压力足够止血，通过伤口周围表面变化判断伤口炎症的状态，进而判断愈合情况；同时，本发明具有可重复使用、低电压驱动、生物兼容性好和易携带等特点。
The invention discloses a micro-system and a realization method for the detection of drug administration by rapid pressure hemostasis with large surface trauma. The invention includes: a flexible PCB board, a signal collector, a processor, a display, a bluetooth module, a pressure airbag isolation mechanism, a small airbag, a large airbag, a temperature sensor, a film pressure sensor, a drug release film, a drug release unit and a biocompatible soluble film The present invention adopts sodium bicarbonate and aluminum sulfate to react to generate carbon dioxide to carry out self-pressurized hemostasis, and simultaneously the pressure-assisted drug releasing mechanism can release drugs in the hemostasis process, which can not only speed up the hemostasis speed but also can add the effect of sterilization and disinfection; A thin film pressure sensor and a temperature sensor are provided to monitor the pressure and the temperature of the wound surface in real time, to ensure that the pressure is sufficient to stop bleeding, and to judge the state of wound inflammation through the change of the surrounding surface of the wound, thereby judging the healing situation; Features such as drive, good biocompatibility and easy portability.
Description
Technical Field
The invention relates to a wound hemostasis microsystem technology, in particular to a rapid pressure hemostasis drug delivery detection microsystem for large surface wounds and an implementation method thereof.
Background
Under emergency environments such as battlefields, earthquakes, fires, operations and the like, the death rate can be greatly reduced by timely stopping bleeding, killing and disposing the wounds suffered by the wounded, so that the research on the micro-system for stopping bleeding and killing has important significance. The currently used hemostasis method mainly comprises a tourniquet, a hemostatic agent, hemostasis powder and the like, needs manual application, has slow hemostasis speed and no detection function, and causes the patient to miss the optimal treatment time due to untimely hemostasis or large-area infection; the electric excitation hemostasis and condensation hemostasis methods require larger equipment to provide energy and are not easy to carry.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a micro-system for detecting rapid pressure hemostasis and drug delivery of large surface wounds and an implementation method thereof, which are applied to an automatic inflation pressurization hemostasis and drug delivery device under the conditions of burst and no joint condition, not only meet the requirement of rapid pressurization hemostasis in gold one hour under the emergency environment, but also meet the requirement of disinfection and sterilization by pressure drug delivery, and simultaneously, a pressure and temperature detection module observes the wound healing condition in real time, thereby increasing the hemostasis effect and shortening the wound healing time.
One object of the present invention is to provide a micro-system for rapid pressure hemostasis drug delivery detection of large surface wounds.
The invention discloses a micro-system for detecting quick pressure hemostasis medicine delivery of large surface wounds, which comprises: the device comprises a flexible PCB, a signal collector, a processor, a display, a Bluetooth module, a pressure air bag isolation mechanism, a small air bag, a large air bag, a temperature sensor, a film pressure sensor, a medicine release film, a medicine release unit and a biocompatible soluble film; the flexible PCB is provided with a signal collector, a processor, a display and a Bluetooth module, the signal collector is connected to the processor, and the processor is respectively connected to the display and the Bluetooth module;
the pressure air bag isolation mechanism comprises a pressing disc, a central rod, a pressure rod limiting pin, a pressure rod limiting groove, a pressing disc sealing ring, an elastic gasket, a large air bag mounting disc, a small air bag mounting disc and a solid-liquid isolation sealing ring; the center of the lower surface of the pressing disc is provided with a coaxial central rod, a pressing rod limiting pin is fixed below the pressing disc and positioned at the top end of the central rod, a coaxial pressing rod limiting groove is sleeved outside the central rod, the diameter of an inner cavity of the pressing rod limiting groove is greater than the length of the pressing rod limiting pin, the diameter of a surface opening of the pressing rod limiting groove is partially greater than the length of the pressing rod limiting pin, and the diameter of a part of the surface opening of the pressing rod limiting groove is less than the length of the pressing rod limiting pin; the bottom of the pressure bar limiting groove is sleeved outside the central rod and is provided with an elastic gasket, and the centers of the elastic gasket and the pressure bar limiting groove are provided with through holes; the sum of the free height of the elastic washer and the height of the compression bar limiting pin is greater than the depth of the compression bar limiting groove; a large air bag mounting disc and a small air bag mounting disc which are coaxial with the central rod are arranged at the bottom outside the pressure rod limiting groove, through holes are formed in the centers of the large air bag mounting disc and the small air bag mounting disc, the small air bag mounting disc is positioned below the large air bag mounting disc, a connecting cylinder which is used for integrally connecting the large air bag mounting disc and the small air bag mounting disc is arranged between the lower surface of the large air bag mounting disc and the upper surface of the small air bag mounting disc, through holes which are coaxial with the central rod are formed in the connecting cylinder, and the central rod penetrates through the through holes in the pressure rod limiting groove mechanism, the sealing ring, the elastic gasket, the large air bag mounting disc, the connecting cylinder and the small air bag mounting disc from the lower surface of the pressing disc; a plurality of liquid inlets are formed in the side wall of the connecting cylinder, a through hole in the center of the small air bag mounting disc is used as a liquid outlet, and a solid-liquid isolating sealing ring is arranged on each liquid inlet; the opening of the small air bag is aligned with the liquid outlet and is arranged on the lower surface of the small air bag mounting plate; the big air bag wraps the small air bag and the small air bag mounting plate, and the opening of the big air bag covers the liquid inlet on the connecting cylinder and is mounted at the edge of the big air bag mounting plate; the small air bag is filled with aluminum sulfate solution; the big air sac is filled with sodium bicarbonate solid; the top end of the central rod penetrates through the surface of the flexible PCB, the pressing disc and the pressing rod limiting groove are positioned on the flexible PCB, an annular pressing disc sealing ring is arranged between the lower surface of the pressing disc and the upper surface of the pressing rod limiting groove, and the pressing disc sealing ring is coaxially sleeved outside the central rod; the large air bag mounting disc, the small air bag mounting disc and the large air bag are positioned below the flexible PCB;
the outer surface of the big air bag is respectively provided with a temperature sensor and a film pressure sensor which are respectively connected to a signal collector; a drug release film is pasted on the lower surface outside the big air sac; a plurality of medicine release units which are uniformly distributed are arranged on the lower surface of the medicine release film, and the medicine release units are embedded into the medicine release film; forming a biocompatible soluble film on the lower surface of the drug release film to cover the plurality of drug release units;
before the use, the pressing disc is pressed downwards, the central rod is rotated, so that the pressing rod limiting pin enters the pressing rod limiting groove through the part with the large diameter of the surface opening of the pressing rod limiting groove, and then the central rod is rotated, so that the pressing rod limiting pin is positioned below the part with the small diameter of the surface opening of the pressing rod limiting groove, and the pressing rod limiting pin is limited in the pressing rod limiting groove; at the moment, the bottom end of the central rod is positioned above the solid-liquid isolation sealing ring, and the distance between the bottom surface of the compression bar limiting pin and the bottom surface of the compression bar limiting groove is larger than the distance between the bottom end of the central rod and the upper surface of the solid-liquid isolation sealing ring;
when the device is used, the biocompatible soluble film is attached to the surface of a wound, the pressing disc is pressed downwards until the bottom end of the central rod is contacted with the solid-liquid isolation sealing ring, so that the solid-liquid isolation sealing ring is broken, the liquid inlet is opened, an aluminum sulfate solution in the small air bag flows through the liquid outlet holes and the liquid inlets on the side wall of the connecting cylinder into the large air bag, and is contacted with the sodium bicarbonate solid in the large air bag to react, so that a large amount of carbon dioxide gas is generated in the large air bag, the large air bag is inflated and pressurized, and the aluminum sulfate solution in the small air bag further flows out under the pressure to fully react; the pressure generated by the big air bag enables the surface big wound rapid pressure hemostasis drug delivery detection micro-system to be pasted on the surface of the skin, so as to compact the wound and perform pressure hemostasis; the biocompatible soluble film is dissolved when being pasted on the surface of the skin, so that the drug release unit is directly contacted with the skin, and the drug is directly released to the surface of the wound, thereby simultaneously realizing the functions of pressure hemostasis and drug disinfection and sterilization; the film pressure sensor and the temperature sensor detect the pressure of the large air bag and the temperature of the wound surface in real time, and the pressure and the temperature are collected by the signal collector and transmitted to the processor; the processor transmits the result to the display for displaying, and transmits the information to a remote mobile phone through the Bluetooth module, and a user checks the pressure and the temperature through the mobile phone; after the flexible PCB is used, the flexible PCB, the signal collector, the processor, the display and the Bluetooth module are arranged on the flexible PCB and are recycled and reused again.
Flexible printed Circuit pcb (printed Circuit board) boards use flexible materials, polyimide film or mylar film.
The elastic washer is made of sponge or latex.
The drug release unit comprises a drug storage container and drugs, the drug storage container is in a bowl shape, the drugs are contained in the drug storage container, the opening of the drug storage container faces downwards, and the drugs are packaged in the drug storage container by a biocompatible soluble film covering the lower surface of the drug release film.
The invention also aims to provide a realization method of the micro system for rapid pressure hemostasis drug delivery detection of the surface large wound.
The invention discloses a method for realizing a rapid pressure hemostasis drug delivery detection microsystem for large surface wounds, which comprises the following steps:
1) before the use, the pressing disc is pressed downwards, the central rod is rotated, so that the pressing rod limiting pin enters the pressing rod limiting groove through the part with the large diameter of the surface opening of the pressing rod limiting groove, and then the central rod is rotated, so that the pressing rod limiting pin is positioned below the part with the small diameter of the surface opening of the pressing rod limiting groove, and the pressing rod limiting pin is limited in the pressing rod limiting groove; at the moment, the bottom end of the central rod is positioned above the solid-liquid isolation sealing ring, and the distance between the bottom surface of the compression bar limiting pin and the bottom surface of the compression bar limiting groove is larger than the distance between the bottom end of the central rod and the upper surface of the solid-liquid isolation sealing ring;
2) when in use, the biocompatible soluble film is pasted on the surface of a wound;
3) pressing the pressing disc downwards until the bottom end of the central rod is in contact with the solid-liquid isolation sealing ring, so that the solid-liquid isolation sealing ring is broken, the liquid inlet is opened, an aluminum sulfate solution in the small air bag flows through the liquid outlet holes and flows through the liquid inlets on the side wall of the connecting cylinder into the large air bag, and the aluminum sulfate solution is in contact with the sodium bicarbonate solid in the large air bag to react, so that a large amount of carbon dioxide gas is generated in the large air bag, the large air bag is inflated and pressurized, and the aluminum sulfate solution in the small air bag further flows out under the pressure to fully react;
4) the pressure generated by the big air bag enables the surface big wound rapid pressure hemostasis drug delivery detection micro-system to be pasted on the surface of the skin, so as to compact the wound and perform pressure hemostasis;
5) the biocompatible soluble film is dissolved when being pasted on the surface of the skin, so that the drug release unit is directly contacted with the skin, and the drug is directly released to the surface of the wound, thereby simultaneously realizing the functions of pressure hemostasis and drug disinfection and sterilization;
6) the film pressure sensor and the temperature sensor detect the pressure of the large air bag and the temperature of the wound surface in real time, and the pressure and the temperature are collected by the signal collector and transmitted to the processor; the processor transmits the result to the display for displaying, and transmits the information to a remote mobile phone through the Bluetooth module, and a user checks the pressure and the temperature through the mobile phone;
7) after the flexible PCB is used, the flexible PCB, the signal collector, the processor, the display and the Bluetooth module are arranged on the flexible PCB and are recycled and reused again.
Further, the user can ensure that the pressure is sufficient for hemostasis through pressure and temperature, and the state of wound inflammation is judged through the change of the peripheral surface of the wound, so that the healing condition is judged.
The invention has the advantages that:
the invention not only satisfies the pressure hemostasis effect in the emergency environment, but also has simple action mode, small equipment volume and convenient carrying; according to the invention, the sodium bicarbonate and the aluminum sulfate react to generate carbon dioxide for autonomous pressurization hemostasis, and the pressure-assisted drug release mechanism can release drugs in the hemostasis process, so that the hemostasis speed can be increased, and the sterilization and disinfection effects can be added; in addition, the wound healing instrument is provided with a film pressure sensor and a temperature sensor, so that the pressure and the temperature of the surface of a wound are monitored in real time, the pressure is ensured to be sufficient for hemostasis, the state of wound inflammation is judged through the change of the surface around the wound, and then the healing condition is judged; meanwhile, the invention has the characteristics of repeated use, low-voltage driving, good biocompatibility, portability and the like.
Drawings
FIG. 1 is a schematic view of one embodiment of the surface atraumatic rapid pressure hemostasis administration detection microsystem of the present invention in a compressed state prior to use;
FIG. 2 is an exploded view of one embodiment of the rapid pressure hemostasis administration detection microsystem of the present invention for surface trauma;
FIG. 3 is a schematic view of a pressure balloon isolation mechanism of one embodiment of the rapid pressure hemostasis administration detection microsystem of the present invention for surface trauma, wherein (a) is an external schematic view and (b) is an exploded view;
FIG. 4 is an exploded cross-sectional view of a pressure balloon isolation mechanism of one embodiment of the rapid pressure hemostasis administration detection microsystem of the present invention for surface trauma;
FIG. 5 is a schematic view of a balloon of one embodiment of the rapid pressure hemostasis administration detection microsystem of the present invention for surface trauma, wherein (a) is an external schematic view and (b) is an exploded view;
figure 6 is a schematic view of a drug delivery film of one embodiment of the rapid pressure hemostasis drug delivery detection microsystem of the present invention for surface trauma.
Detailed Description
The invention will be further elucidated by means of specific embodiments in the following with reference to the drawing.
As shown in fig. 1, the micro-system for rapid hemostasis by pressure administration for surface large wound of the present invention of the present embodiment comprises: the device comprises a flexible PCB (printed circuit board) 1, a signal collector, a processor, a display, a Bluetooth module, a pressure air bag isolation mechanism 2, a small air bag 3, a large air bag 4, a temperature sensor, a film pressure sensor 5, a medicine release film 6, a medicine release unit 7 and a biocompatible soluble film 8; the flexible PCB is provided with a signal collector, a processor, a display and a Bluetooth module, the signal collector is connected to the processor, and the processor is connected to the display and the Bluetooth module respectively;
as shown in fig. 2 to 5, the pressure airbag isolation mechanism includes a pressing disc 21, a central rod 22, a pressing rod limiting pin 23, a pressing rod limiting groove 24, a pressing disc sealing ring 25, an elastic washer 26, a large airbag mounting disc 27, a small airbag mounting disc 28 and a solid-liquid isolation sealing ring 29; the center of the lower surface of the pressing disc is provided with a coaxial central rod, a pressing rod limiting pin is fixed below the pressing disc and positioned at the top end of the central rod, a coaxial pressing rod limiting groove is sleeved outside the central rod, the diameter of an inner cavity of the pressing rod limiting groove is greater than the length of the pressing rod limiting pin, the diameter of a surface opening of the pressing rod limiting groove is partially greater than the length of the pressing rod limiting pin, and the diameter of a part of the surface opening of the pressing rod limiting groove is less than the length of the pressing rod limiting pin; the bottom of the pressure bar limiting groove is sleeved outside the central rod and is provided with an annular elastic gasket, and the centers of the elastic gasket and the pressure bar limiting groove are provided with through holes; the sum of the free height of the elastic washer and the height of the compression bar limiting pin is greater than the depth of the compression bar limiting groove; a large air bag mounting disc and a small air bag mounting disc which are coaxial with the central rod are arranged at the bottom outside the pressure rod limiting groove, through holes are formed in the centers of the large air bag mounting disc and the small air bag mounting disc, the small air bag mounting disc is positioned below the large air bag mounting disc, a connecting cylinder which is used for integrally connecting the large air bag mounting disc and the small air bag mounting disc is arranged between the lower surface of the large air bag mounting disc and the upper surface of the small air bag mounting disc, a through hole which is coaxial with the central rod is formed in the connecting cylinder, the inner diameter of the through hole is larger than the outer diameter of the central rod, and the central rod penetrates through the through holes in the pressure rod limiting groove mechanism, the sealing ring, the elastic washer, the large air bag mounting disc and the connecting cylinder and the small air bag mounting disc from the lower surface of the pressing disc; the side wall of the connecting cylinder is provided with four liquid inlets 41, a through hole in the center of the small air bag mounting disc is used as a liquid outlet 31, and a solid-liquid isolating sealing ring is arranged on each liquid inlet; the opening of the small air bag is aligned with the liquid outlet and is arranged on the lower surface of the small air bag mounting plate; the big air bag wraps the small air bag and the small air bag mounting plate, and the opening of the big air bag covers the liquid inlet on the connecting cylinder and is mounted at the edge of the big air bag mounting plate; the small air bag is filled with aluminum sulfate solution; the big air sac is filled with sodium bicarbonate solid; the top end of the central rod penetrates through the surface of the flexible PCB, the pressing disc and the pressing rod limiting groove are positioned on the flexible PCB, a pressing disc sealing ring is arranged between the lower surface of the pressing disc and the upper surface of the pressing rod limiting groove, and the pressing disc sealing ring is coaxially sleeved outside the central rod; the large air bag mounting disc, the small air bag mounting disc and the large air bag are positioned below the flexible PCB;
the outer surface of the big air bag is respectively provided with a temperature sensor and a film pressure sensor which are respectively connected to a signal collector; a drug release film is pasted on the lower surface outside the big air sac; a plurality of medicine release units which are uniformly distributed are arranged on the lower surface of the medicine release film, and the medicine release units are embedded into the medicine release film, as shown in figure 6; a biocompatible soluble film is formed on the lower surface of the drug release film to cover a plurality of drug release units.
The implementation method of the micro system for rapid pressure hemostasis drug delivery of the large surface wound comprises the following steps:
1) before the use, the pressing disc is pressed downwards, the central rod is rotated, so that the pressing rod limiting pin enters the pressing rod limiting groove through the part with the large diameter of the surface opening of the pressing rod limiting groove, and then the central rod is rotated, so that the pressing rod limiting pin is positioned below the part with the small diameter of the surface opening of the pressing rod limiting groove, and the pressing rod limiting pin is limited in the pressing rod limiting groove; at the moment, the bottom end of the central rod is positioned above the solid-liquid isolation sealing ring, and the distance between the bottom surface of the compression bar limiting pin and the bottom surface of the compression bar limiting groove is larger than the distance between the bottom end of the central rod and the upper surface of the solid-liquid isolation sealing ring;
2) when in use, the biocompatible soluble film is pasted on the surface of a wound;
3) pressing the pressing disc downwards until the bottom end of the central rod is in contact with the solid-liquid isolation sealing ring, so that the solid-liquid isolation sealing ring is broken, the liquid inlet is opened, an aluminum sulfate solution in the small air bag flows through the liquid outlet holes and flows through the liquid inlets on the side wall of the connecting cylinder into the large air bag, the aluminum sulfate solution is in contact reaction with the sodium bicarbonate solid in the large air bag, a large amount of carbon dioxide gas is generated in the large air bag through reaction, the large air bag is inflated and pressurized, and the aluminum sulfate solution in the small air bag further flows out under the pressure so as to fully react;
4) the pressure generated by the big air bag enables the surface big wound rapid pressure hemostasis drug delivery detection micro-system to be pasted on the surface of the skin, so as to compact the wound and perform pressure hemostasis;
5) the biocompatible soluble film is dissolved when being pasted on the surface of the skin, so that the drug release unit is directly contacted with the skin, and the drug is directly released to the surface of the wound, thereby simultaneously realizing the functions of pressure hemostasis and drug disinfection and sterilization;
6) the film pressure sensor and the temperature sensor detect the pressure of the large air bag and the temperature of the wound surface in real time, and the pressure and the temperature are collected by the signal collector and transmitted to the processor; the processor transmits the result to the display for display, and transmits information to the remote mobile phone through the Bluetooth module, and the user checks the pressure and the temperature through the mobile phone, further judges the state of the wound inflammation through ensuring that the pressure is sufficient to stop bleeding and changes the surface around the wound, and further judges the healing condition;
7) after the flexible PCB is used, the flexible PCB, the signal collector, the processor, the display and the Bluetooth module are arranged on the flexible PCB and are recycled and reused again.
Finally, it is noted that the disclosed embodiments are intended to aid in further understanding of the invention, but those skilled in the art will appreciate that: various substitutions and modifications are possible without departing from the spirit and scope of the invention and the appended claims. Therefore, the invention should not be limited to the embodiments disclosed, but the scope of the invention is defined by the appended claims.
Claims (5)
1. A superficial large wound rapid pressure hemostasis administration detection microsystem, the superficial large wound rapid pressure hemostasis administration detection microsystem comprising: the device comprises a flexible PCB, a signal collector, a processor, a display, a Bluetooth module, a pressure air bag isolation mechanism, a small air bag, a large air bag, a temperature sensor, a film pressure sensor, a medicine release film, a medicine release unit and a biocompatible soluble film; the flexible PCB is provided with a signal collector, a processor, a display and a Bluetooth module, the signal collector is connected to the processor, and the processor is respectively connected to the display and the Bluetooth module;
the pressure air bag isolation mechanism comprises a pressing disc, a central rod, a pressure rod limiting pin, a pressure rod limiting groove, a pressing disc sealing ring, an elastic gasket, a large air bag mounting disc, a small air bag mounting disc and a solid-liquid isolation sealing ring; the center of the lower surface of the pressing disc is provided with a coaxial central rod, a pressing rod limiting pin is fixed below the pressing disc and positioned at the top end of the central rod, a coaxial pressing rod limiting groove is sleeved outside the central rod, the diameter of an inner cavity of the pressing rod limiting groove is greater than the length of the pressing rod limiting pin, the diameter of a surface opening of the pressing rod limiting groove is partially greater than the length of the pressing rod limiting pin, and the diameter of a part of the surface opening of the pressing rod limiting groove is less than the length of the pressing rod limiting pin; the bottom of the pressure bar limiting groove is sleeved outside the central rod and is provided with an elastic gasket, and the centers of the elastic gasket and the pressure bar limiting groove are provided with through holes; the sum of the free height of the elastic washer and the height of the compression bar limiting pin is greater than the depth of the compression bar limiting groove; a large air bag mounting disc and a small air bag mounting disc which are coaxial with the central rod are arranged at the bottom outside the pressure rod limiting groove, through holes are formed in the centers of the large air bag mounting disc and the small air bag mounting disc, the small air bag mounting disc is positioned below the large air bag mounting disc, a connecting cylinder which is used for integrally connecting the large air bag mounting disc and the small air bag mounting disc is arranged between the lower surface of the large air bag mounting disc and the upper surface of the small air bag mounting disc, through holes which are coaxial with the central rod are formed in the connecting cylinder, and the central rod penetrates through the through holes in the pressure rod limiting groove mechanism, the sealing ring, the elastic gasket, the large air bag mounting disc, the connecting cylinder and the small air bag mounting disc from the lower surface of the pressing disc; a plurality of liquid inlets are formed in the side wall of the connecting cylinder, a through hole in the center of the small air bag mounting disc is used as a liquid outlet, and a solid-liquid isolating sealing ring is arranged on each liquid inlet; the opening of the small air bag is aligned with the liquid outlet and is arranged on the lower surface of the small air bag mounting plate; the big air bag wraps the small air bag and the small air bag mounting plate, and the opening of the big air bag covers the liquid inlet on the connecting cylinder and is mounted at the edge of the big air bag mounting plate; the small air bag is filled with aluminum sulfate solution; the big air sac is filled with sodium bicarbonate solid; the top end of the central rod penetrates through the surface of the flexible PCB, the pressing disc and the pressing rod limiting groove are positioned on the flexible PCB, an annular pressing disc sealing ring is arranged between the lower surface of the pressing disc and the upper surface of the pressing rod limiting groove, and the pressing disc sealing ring is coaxially sleeved outside the central rod; the large air bag mounting disc, the small air bag mounting disc and the large air bag are positioned below the flexible PCB;
the outer surface of the big air bag is respectively provided with a temperature sensor and a film pressure sensor which are respectively connected to a signal collector; a drug release film is pasted on the lower surface outside the big air sac; a plurality of medicine release units which are uniformly distributed are arranged on the lower surface of the medicine release film, and the medicine release units are embedded into the medicine release film; forming a biocompatible soluble film on the lower surface of the drug release film to cover the plurality of drug release units;
before the use, the pressing disc is pressed downwards, the central rod is rotated, so that the pressing rod limiting pin enters the pressing rod limiting groove through the part with the large diameter of the surface opening of the pressing rod limiting groove, and then the central rod is rotated, so that the pressing rod limiting pin is positioned below the part with the small diameter of the surface opening of the pressing rod limiting groove, and the pressing rod limiting pin is limited in the pressing rod limiting groove; at the moment, the bottom end of the central rod is positioned above the solid-liquid isolation sealing ring, and the distance between the bottom surface of the compression bar limiting pin and the bottom surface of the compression bar limiting groove is larger than the distance between the bottom end of the central rod and the upper surface of the solid-liquid isolation sealing ring;
when the device is used, the biocompatible soluble film is attached to the surface of a wound, the pressing disc is pressed downwards until the bottom end of the central rod is contacted with the solid-liquid isolation sealing ring, so that the solid-liquid isolation sealing ring is broken, the liquid inlet is opened, an aluminum sulfate solution in the small air bag flows through the liquid outlet holes and the liquid inlets on the side wall of the connecting cylinder into the large air bag, and is contacted with the sodium bicarbonate solid in the large air bag to react, so that a large amount of carbon dioxide gas is generated in the large air bag, the large air bag is inflated and pressurized, and the aluminum sulfate solution in the small air bag further flows out under the pressure to fully react; the pressure generated by the big air bag enables the surface big wound rapid pressure hemostasis drug delivery detection micro-system to be pasted on the surface of the skin, so as to compact the wound and perform pressure hemostasis; the biocompatible soluble film is dissolved when being pasted on the surface of the skin, so that the drug release unit is directly contacted with the skin, and the drug is directly released to the surface of the wound, thereby simultaneously realizing the functions of pressure hemostasis and drug disinfection and sterilization; the film pressure sensor and the temperature sensor detect the pressure of the large air bag and the temperature of the wound surface in real time, and the pressure and the temperature are collected by the signal collector and transmitted to the processor; the processor transmits the result to the display for displaying, and transmits the information to a remote mobile phone through the Bluetooth module, and a user checks the pressure and the temperature through the mobile phone; after the flexible PCB is used, the flexible PCB, the signal collector, the processor, the display and the Bluetooth module are arranged on the flexible PCB and are recycled and reused again.
2. The rapid pressure hemostasis drug delivery detection microsystem of claim 1, wherein the flexible printed circuit board is made of a flexible material.
3. The micro-system for rapid pressure hemostasis drug delivery detection of surface wounds and large wounds as claimed in claim 1, wherein the material of the elastic washer is sponge or latex.
4. The micro-system for rapid pressure hemostasis drug delivery detection of large surface wounds, as claimed in claim 1, wherein the drug release unit comprises a drug storage container and a drug, the drug storage container is in a bowl shape, the drug is contained in the drug storage container, the opening of the drug storage container faces downwards, and the drug is encapsulated in the drug storage container by a biocompatible dissolvable film covering the lower surface of the drug release film.
5. A method for implementing the rapid pressure hemostasis drug delivery detection microsystem for surface large wounds, according to claim 1, wherein the method comprises the following steps:
1) before the use, the pressing disc is pressed downwards, the central rod is rotated, so that the pressing rod limiting pin enters the pressing rod limiting groove through the part with the large diameter of the surface opening of the pressing rod limiting groove, and then the central rod is rotated, so that the pressing rod limiting pin is positioned below the part with the small diameter of the surface opening of the pressing rod limiting groove, and the pressing rod limiting pin is limited in the pressing rod limiting groove; at the moment, the bottom end of the central rod is positioned above the solid-liquid isolation sealing ring, and the distance between the bottom surface of the compression bar limiting pin and the bottom surface of the compression bar limiting groove is larger than the distance between the bottom end of the central rod and the upper surface of the solid-liquid isolation sealing ring;
2) when in use, the biocompatible soluble film is pasted on the surface of a wound;
3) pressing the pressing disc downwards until the bottom end of the central rod is in contact with the solid-liquid isolation sealing ring, so that the solid-liquid isolation sealing ring is broken, the liquid inlet is opened, an aluminum sulfate solution in the small air bag flows through the liquid outlet holes and flows through the liquid inlets on the side wall of the connecting cylinder into the large air bag, and the aluminum sulfate solution is in contact with the sodium bicarbonate solid in the large air bag to react, so that a large amount of carbon dioxide gas is generated in the large air bag, the large air bag is inflated and pressurized, and the aluminum sulfate solution in the small air bag further flows out under the pressure to fully react;
4) the pressure generated by the big air bag enables the surface big wound rapid pressure hemostasis drug delivery detection micro-system to be pasted on the surface of the skin, so as to compact the wound and perform pressure hemostasis;
5) the biocompatible soluble film is dissolved when being pasted on the surface of the skin, so that the drug release unit is directly contacted with the skin, and the drug is directly released to the surface of the wound, thereby simultaneously realizing the functions of pressure hemostasis and drug disinfection and sterilization;
6) the film pressure sensor and the temperature sensor detect the pressure of the large air bag and the temperature of the wound surface in real time, and the pressure and the temperature are collected by the signal collector and transmitted to the processor; the processor transmits the result to the display for displaying, and transmits the information to a remote mobile phone through the Bluetooth module, and a user checks the pressure and the temperature through the mobile phone;
7) after the flexible PCB is used, the flexible PCB, the signal collector, the processor, the display and the Bluetooth module are arranged on the flexible PCB and are recycled and reused again.
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