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CN113631582A - 一种融合蛋白及其用途 - Google Patents

一种融合蛋白及其用途 Download PDF

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CN113631582A
CN113631582A CN202080023723.7A CN202080023723A CN113631582A CN 113631582 A CN113631582 A CN 113631582A CN 202080023723 A CN202080023723 A CN 202080023723A CN 113631582 A CN113631582 A CN 113631582A
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fusion protein
seq
amino acid
cancer
antibody
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CN113631582B (zh
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吕明
丁晓然
缪仕伟
谈彬
王学恭
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Hangzhou Sumgen Biotech Co Ltd
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Hangzhou Sumgen Biotech Co Ltd
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract

提供一种融合蛋白、与其相关的免疫缀合物、核酸分子、载体、组合物、细胞和制备方法，用于治疗肿瘤和/或自免疫疾病。

Description

PCT国内申请，说明书已公开。

Claims (41)

  1. PCT国内申请，权利要求书已公开。
CN202080023723.7A 2019-04-02 2020-04-01 一种融合蛋白及其用途 Active CN113631582B (zh)

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CN201910260447.5A CN111763261B (zh) 2019-04-02 2019-04-02 一种融合蛋白及其用途
CN2019102604475 2019-04-02
PCT/CN2020/082861 WO2020200256A1 (zh) 2019-04-02 2020-04-01 一种融合蛋白及其用途

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CN113631582A true CN113631582A (zh) 2021-11-09
CN113631582B CN113631582B (zh) 2024-09-06

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US (1) US20220251154A1 (zh)
EP (1) EP3950720A4 (zh)
JP (1) JP2022527705A (zh)
KR (1) KR20210146916A (zh)
CN (2) CN111763261B (zh)
AU (1) AU2020250613A1 (zh)
BR (1) BR112021019570A2 (zh)
CA (1) CA3131075A1 (zh)
SG (1) SG11202110400QA (zh)
WO (1) WO2020200256A1 (zh)

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TW202235104A (zh) * 2020-11-18 2022-09-16 中國大陸商蘇州創勝醫藥集團有限公司 雙功能分子
MX2023009715A (es) * 2021-02-19 2024-01-08 Shaperon Inc Anticuerpo de dominio individual biespecífico contra el ligando de muerte programada (pd-l1) y el cúmulo de diferenciación 47 (cd47) y uso del mismo.
CN113773401B (zh) * 2021-09-15 2023-06-20 宜明昂科生物医药技术（上海）股份有限公司 靶向cd47和pd-l1的重组融合蛋白及其制备和用途
CN118139874A (zh) * 2021-11-01 2024-06-04 山东先声生物制药有限公司 SIRPa突变体及其应用
CN116178561B (zh) * 2021-11-26 2025-07-18 杭州尚健生物技术有限公司 包含SIRPα突变体的融合蛋白
WO2025002429A1 (zh) * 2023-06-28 2025-01-02 北京哲源科技有限责任公司 靶向pd-l1和il-1的双特异性抗体及其用途

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CN103608684A (zh) * 2011-05-12 2014-02-26 基因泰克公司 利用框架签名肽检测动物样品中的治疗性抗体的多重反应监测lc-ms/ms方法
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CN107108748A (zh) * 2014-08-15 2017-08-29 默克专利有限公司 SIRPα免疫球蛋白融合蛋白
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WO2018107058A1 (en) * 2016-12-09 2018-06-14 Alector Llc Anti-sirp-alpha antibodies and methods of use thereof
CN109517054A (zh) * 2018-12-04 2019-03-26 江苏东抗生物医药科技有限公司 SIRPα变体或其融合蛋白及其应用
CN109535263A (zh) * 2018-12-04 2019-03-29 江苏东抗生物医药科技有限公司 SIRPα突变体及其融合蛋白

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CN113621075B (zh) * 2014-08-08 2024-09-20 Alx肿瘤生物技术公司 SIRP-α变体构建体及其用途
IL302491A (en) * 2015-08-07 2023-06-01 Alx Oncology Inc Constructs having a sirp-alpha domain or variant thereof
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KR102714455B1 (ko) * 2017-05-08 2024-10-07 상하이 제이엠티-바이오 테크노로지 컴퍼니 리미티드 이중특이성 재조합단백질 및 이의 응용

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103608684A (zh) * 2011-05-12 2014-02-26 基因泰克公司 利用框架签名肽检测动物样品中的治疗性抗体的多重反应监测lc-ms/ms方法
CN107108748A (zh) * 2014-08-15 2017-08-29 默克专利有限公司 SIRPα免疫球蛋白融合蛋白
CN107922470A (zh) * 2015-08-07 2018-04-17 皮里斯制药有限公司 对lag‑3和pd‑1特异性的新型融合多肽
CN107459578A (zh) * 2016-05-31 2017-12-12 泰州迈博太科药业有限公司 一种靶向cd47与pd‑l1的双功能融合蛋白
CN106967172A (zh) * 2016-08-23 2017-07-21 中山康方生物医药有限公司 抗ctla4‑抗pd‑1 双功能抗体、其药物组合物及其用途
WO2018107058A1 (en) * 2016-12-09 2018-06-14 Alector Llc Anti-sirp-alpha antibodies and methods of use thereof
CN109517054A (zh) * 2018-12-04 2019-03-26 江苏东抗生物医药科技有限公司 SIRPα变体或其融合蛋白及其应用
CN109535263A (zh) * 2018-12-04 2019-03-29 江苏东抗生物医药科技有限公司 SIRPα突变体及其融合蛋白

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BR112021019570A2 (pt) 2021-11-30
AU2020250613A1 (en) 2021-11-11
CA3131075A1 (en) 2020-10-08
CN113631582B (zh) 2024-09-06
SG11202110400QA (en) 2021-10-28
CN111763261A (zh) 2020-10-13
WO2020200256A1 (zh) 2020-10-08
JP2022527705A (ja) 2022-06-03
EP3950720A4 (en) 2023-04-12
KR20210146916A (ko) 2021-12-06
US20220251154A1 (en) 2022-08-11
CN111763261B (zh) 2022-08-09
EP3950720A1 (en) 2022-02-09

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