CN113616626A - Medical application with anesthesia effect and application thereof - Google Patents
Medical application with anesthesia effect and application thereof Download PDFInfo
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- CN113616626A CN113616626A CN202111023208.1A CN202111023208A CN113616626A CN 113616626 A CN113616626 A CN 113616626A CN 202111023208 A CN202111023208 A CN 202111023208A CN 113616626 A CN113616626 A CN 113616626A
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- disinfectant
- material layer
- anesthetic
- layer
- medical application
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
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- LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to the technical field of medicines, and provides a medical application with an anesthetic effect and application thereof, wherein the medical application comprises a medical application body I loaded with a disinfectant and an anesthetic packaged independently; medical application body one includes: a base material layer; a peel-off protective layer adhered to the base material layer at the peripheral portion; and an absorbent substrate layer between the peel-protective layer and the substrate material layer. The medical application has the advantages that the disinfectant is directly placed in the medical application, so that the medical application has a disinfecting effect; in the surgical clinical application, the anesthetic is used together or sequentially, so that the efficiency is improved, the cost is reduced, and the infection risk in the surgical clinical application process can be reduced to a certain extent; the medical application can not only sterilize and anaesthetize at the same time or in succession, but also flexibly adjust the dosage of the anaesthetics according to individual difference, and has short effect taking time, long drug effect time and good anaesthesia and sterilization effect.
Description
Technical Field
The invention belongs to the technical field of medical supplies, and provides a medical application with an anesthesia effect and application thereof.
Background
Local anesthetics (localanaesthetics) are drugs which can reversibly block the generation and transmission of sensory nerve impulses when applied locally, and are called local anesthetics for short. Reversibly causing local tissue analgesia while keeping the patient awake. The action of local anesthetics is generally localized to the site of administration and rapidly diminishes as the drug diffuses from the site of administration. The currently applied methods mainly include superficial anesthesia, infiltration anesthesia, conduction anesthesia, subarachnoid anesthesia and epidural anesthesia. In surgical clinical application, generally, anesthetic is injected to perform anesthesia, but the injection anesthesia has long drug effect time, corresponding disinfection treatment is needed before injection, the time consumption is relatively long, certain pain is generated during injection, and certain psychological pressure and physiological pressure can be added to a patient. The wound is disinfected by using a disinfectant before anesthesia, and then local anesthetic is injected or smeared, so that the wound is exposed for a long time and is complex to operate, and the injection has a certain effect-taking time, and accordingly, the risk of infection in surgical clinical application is increased.
At present, the application of the sterile application is wide, more of the sterile application is single anesthesia application, and the application with a disinfection function is not common. For example, CN201620020044.5 discloses a take anesthetic applying ointment or plaster, including applying ointment or plaster the body, soak tetracaine's cotton layer and overburden, apply ointment or plaster the body and be equipped with the perforation, wherein one side fixed connection is on the body that applies ointment or plaster at perforation edge on the cotton layer edge, apply ointment or plaster the body and be equipped with the rubber coating bottom towards the skin face, apply ointment or plaster the body and pass through viscose looks adaptation with the overburden, the overburden covers at the body that applies ointment or plaster dorsad skin face, the overburden is equipped with observation window, observation window and perforation coincidence, take anesthetic applying ointment or plaster to seal in the wrapping bag. CN201980008813.6 discloses a pharmaceutical composition, a patch, a preparation method, an analgesic method and application thereof. The pharmaceutical composition comprises a single anesthetic active ingredient comprising an anesthetic active ingredient dissolved in water and an anesthetic active ingredient in an undissolved state; the mass percentage of the anesthetic active component in the pharmaceutical composition is more than 2 percent; the mass percentage of the anesthetic active ingredient dissolved in water in the pharmaceutical composition is less than 1%; the anesthetic active ingredient is lidocaine, tetracaine, bupivacaine, articaine, cinchocaine, dibucaine, etidocaine, levobupivacaine, mepivacaine, prilocaine, ropivacaine, tricaine, benzocaine or procaine. Both of the above two patents are single anesthesia application, and the wound needs to be disinfected in advance during the use process. In surgical clinical applications, disinfection and anesthesia are often used in combination, and if performed separately, they are not only costly but also time consuming, and present a risk of infection. In addition, when the injection anesthesia is performed, if adverse reactions occur during the use of a patient, the adverse reactions are difficult to stop in time and are easy to generate more serious adverse reactions.
In the existing surgical clinical application process, a disinfectant is used for disinfection first, then an anesthetic is injected, the exposure time of a skin wound is long, the operation is complex, the effect taking time after the injection of the anesthetic is long, and accordingly the infection risk in the surgical clinical application is increased. In view of the defects of the existing surgical clinical application, a medical application with an anesthetic effect needs to be developed, and the technical blank that the existing medical application has both the sterilizing and anesthetic effects is filled.
Disclosure of Invention
In order to solve the defect that the application function is too single in the prior art, the invention provides the medical application with the anesthesia effect and the application thereof, and the medical application has the sterilization function by directly placing the disinfectant in the medical application; in the surgical clinical application, the anesthetic is used together or sequentially, so that the efficiency is improved, the cost is reduced, and the infection risk in the surgical clinical application process can be reduced to a certain extent; the medical application can be used for disinfecting and anaesthetizing at the same time or in succession, the dosage of the anaesthetic can be flexibly adjusted according to individual difference, the acting time is short, the drug effect time is long, and the anaesthetic disinfecting effect is good.
Specifically, the invention is realized by the following technical schemes:
in a first aspect, the invention provides a product comprising an anesthetic and a disinfectant, as a combined preparation for separate, simultaneous or sequential use in disinfecting anesthesia during surgical clinical use. The surgical clinical application procedure includes pre-operative, post-operative, intra-operative and other clinical studies.
Further, the product comprising the anesthetic and disinfectant is administered transdermally.
Further, the product containing anesthetic and disinfectant is a medical application combination product containing anesthetic and disinfectant. The residual amount of ethylene oxide in the medical application combination product of the invention is not more than 10 ug/g.
Further, the disinfectant is various clinically and surgically acceptable disinfectants, and the active component in the disinfectant is selected from quaternary ammonium salts, biguanides and iodine-containing disinfectants, such as one or more of biquaternary ammonium salt TS-838, octadecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium bromide, cetylpyridinium chloride, benzalkonium bromide, benzalkonium chloride, and dodecyl dimethyl phenoxyethyl ammonium bromide. The disinfectant solution can be prepared from the finished disinfectant on the market, and can also be diluted to 70-95% of the original concentration by using sterile water. The disinfectant solution mentioned in the invention is a product which can be applied to the disinfection of human skin.
Further, the anesthetic is administered by injection. Further, the anesthetic is clinically and surgically acceptable various anesthetics, including aqueous solutions of active ingredients and buffers. Further, the active ingredient in the anesthetic is selected from the group consisting of para-aminobenzoates, amides, amino ethers, and aminoketones, for example, one selected from procaine, benzocaine, butamben, dibucaine, lidocaine, mepivacaine, dyclonine, bupivacaine, etidocaine, prilocaine, ropivacaine, oxybuprocaine, pramoxine, proparacaine, proxymetacaine, novocaine, tetracaine, and the like.
Further, the anesthetic may be varied accordingly depending on the individual unit dose used. The specific dose level for any particular patient will depend upon a variety of factors including the age, body weight, general health, sex, diet, time of administration, drug combination and the severity of the particular condition being treated.
For administration of the anesthetic by injection, the aqueous solution of the buffer contained may be in the form of a sterile injectable aqueous or nonaqueous solution or suspension. For example: 1, 3-butanediol, phosphate buffered saline, ringer's solution, isotonic sodium chloride solution and the like, or sterile, fixed oils as a solvent or suspending medium, such as mono-or diglycerides and the like. The anesthetic can be a commercial anesthetic finished product, or can be diluted to 2-25% of the original concentration by 50% ethanol.
In some embodiments, the medical applicator combination product containing anesthetic and disinfectant includes a disinfectant-laden medical applicator body and an independently packaged anesthetic; the medical application body I of the invention comprises:
a base material layer;
a peel-off protective layer adhered to the base material layer at a peripheral portion;
and an absorbent substrate layer between the peel-off protection layer and the substrate material layer.
Further, the base material layer is made by coating medical pressure-sensitive adhesive on a material with high moisture and air permeability as a base material, wherein the base material comprises but is not limited to non-woven fabrics, gauze, polyurethane composite films, cotton cloth, silk and the like; further, the substrate material layer is provided with a hole for injection and a channel radiating with the hole as the center; the channel is arranged on one side of the substrate material layer facing the absorption substrate layer; the channels are formed by discontinuous coatings of medical pressure-sensitive adhesive, and solution among the channels can be rapidly distributed on the surface of the absorption substrate layer in a penetrating manner. The distance between the channels can be equally spaced, and the arrangement rule can be regular or irregular without special limitation. The medical pressure-sensitive adhesive can be coated by printing, spraying, reverse roll coating, extrusion coating, scraper coating and the like.
Furthermore, the peeling protective layer is a release film or paper coated with a silicone oil anti-sticking agent, and the peeling protective layer is torn off when the medical application body is used, so that the medical application body can be attached to the skin of a human body.
Further, the absorbent substrate layer comprises an absorbent material layer and a release film attached to the side of the absorbent material layer facing the peel-off protection layer. The isolating membrane can be a porous polyethylene film, a net or a grid mesh and other materials with high permeability. Furthermore, the absorption substrate layer comprises an absorption material layer formed by one or two of viscose, acetate, cuprammonium, polyester, polypropylene, polyvinyl chloride or polyester fibers and a polyethylene isolating film attached to one side of the absorption material layer facing the stripping protective layer; the absorption substrate layer is high in fit degree with the skin; the active ingredients in the patch can be contacted with the skin, and secretion, water, blood and the like on the surface of the skin can rapidly enter the patch.
Further, the absorbent material layer is loaded with a disinfectant. The preparation process of the disinfectant loaded on the absorbing material layer is as follows: and soaking the absorbing material in disinfectant solution, taking out the absorbing material after adsorption saturation, and removing moisture to obtain the absorbing material layer loaded with the disinfectant. Further, the moisture removing means includes: oven drying, freeze drying, air drying, etc.
Further, the absorbing material layer is loaded with a disinfectant, and the preparation process comprises the following steps: the preparation process of the disinfectant loaded on the absorbing material layer is as follows: and loading the disinfectant solution in the medicine carrying sac and then spreading the medicine carrying sac on the surface layer of the absorption material to obtain the absorption material layer loaded with the disinfectant. Further, the disinfectant solution loaded in the medicine-loading bag is easy to flow out due to extrusion damage under the action of external force.
Further, the substrate material layer and the isolation film form a cavity, and the absorption material layer is positioned in the cavities of the substrate material layer and the isolation film; the substrate material layer is connected with the isolating film in a bonding mode, a pressing mode and the like; the area of the substrate material layer is slightly larger than that of the isolating film; the fixing belts are arranged on the periphery of the base material layer and are of hook and loop fastener adhesion structures and are positioned at the same positions of two opposite sides of the base material layer; the middle of the fixing belt can be provided with an elastic band, for example, the size is adjusted, so that the absorption basal layer is convenient to be close to the skin surface; set up the magic binding face with one side fixed band, another sets up magic tape matt surface with one side fixed band.
Further, the edge of the peeling protective layer covers the edge of the base material layer, and a sterile environment of the medical application is realized before use. Clean water is used for cleaning the wound, the stripping protective layer is removed and then is applied to the wound, pathogenic bacteria on the wound are killed, the wound is placed in the aseptic environment of the application, disinfection and anesthesia are carried out simultaneously, and secondary infection and injury are prevented.
In other embodiments, the medical application combination product containing the anesthetic and the disinfectant comprises a second medical application body loaded with the disinfectant and the anesthetic simultaneously;
the second medical application body of the invention comprises:
a base material layer;
a peel-off protective layer adhered to the base material layer at a peripheral portion;
and an absorbent substrate layer between the peel-off protection layer and the substrate material layer.
Further, the base material layer is made by coating medical pressure-sensitive adhesive on a material with high moisture and air permeability as a base material, wherein the base material comprises but is not limited to non-woven fabrics, gauze, polyurethane composite films, cotton cloth, silk and the like; further, the substrate material layer is provided with a hole for injection and a channel radiating with the hole as the center; the channel is arranged on one side of the substrate material layer facing the absorption substrate layer; the channels are formed by discontinuous coatings of medical pressure-sensitive adhesive, and solution among the channels can be rapidly distributed on the surface of the absorption substrate layer in a penetrating manner. The distance between the channels can be equally spaced, and the arrangement rule can be regular or irregular without special limitation. The medical pressure-sensitive adhesive can be coated by printing, spraying, reverse roll coating, extrusion coating, scraper coating and the like.
Further, the peeling protective layer is a release film or paper coated with a silicone oil anti-sticking agent, and when the medical application body II is used, the peeling protective layer is torn off, so that the medical application body II can be attached to the skin of a human body.
Further, the absorbent substrate layer comprises an absorbent material layer and a release film attached to the side of the absorbent material layer facing the peel-off protection layer. The isolating membrane can be a porous polyethylene film, a net or a grid mesh and other materials with high permeability. Furthermore, the absorption substrate layer comprises an absorption material layer formed by one or two of viscose, acetate, cuprammonium, polyester, polypropylene, polyvinyl chloride or polyester fibers and a polyethylene isolating film attached to one side of the absorption material layer facing the stripping protective layer; the absorption substrate layer is high in fit degree with the skin; the active ingredients in the patch can be contacted with the skin, and secretion, water, blood and the like on the surface of the skin can rapidly enter the patch.
Further, the absorbent material layer is loaded with a disinfectant and an anesthetic. The preparation process of the absorbing material loaded with the disinfectant and the anesthetic comprises the following steps: soaking the absorbing material in disinfectant solution, taking out the absorbing material after adsorption saturation to remove moisture, and obtaining the absorbing material loaded with the disinfectant; and uniformly distributing the anesthetic solution on the surface of the disinfectant-loaded absorbing material, and removing moisture to obtain the disinfectant-loaded and anesthetic-loaded absorbing material. Further, the moisture removing means includes: oven drying, freeze drying, air drying, etc. Further, the uniform distribution manner includes coating or soaking or spraying, etc.
Further, the substrate material layer and the isolation film form a cavity, and the absorption material layer is positioned in the cavities of the substrate material layer and the isolation film; the substrate material layer is connected with the isolating film in a bonding mode, a pressing mode and the like; the area of the substrate material layer is slightly larger than that of the isolating film; the fixing belts are arranged on the periphery of the base material layer and are of hook and loop fastener adhesion structures and are positioned at the same positions of two opposite sides of the base material layer; the middle of the fixing belt can be provided with an elastic band, for example, the size is adjusted, so that the absorption basal layer is convenient to be close to the skin surface; set up the magic binding face with one side fixed band, another sets up magic tape matt surface with one side fixed band.
Further, the edge of the peeling protective layer covers the edge of the base material layer, and a sterile environment of the medical application is realized before use.
In a second aspect, the invention provides an application of a medical application with anesthetic effect, which comprises the following specific processes:
soaking the absorbing material layer in disinfectant solution until the absorbing material layer is saturated in adsorption, and removing moisture to obtain the absorbing material layer adsorbed with the solid disinfectant;
coating the absorbing material layer to prepare a medical application;
when in use, the stripping protective layer of the medical application is removed, and the medical application is applied to the affected part through the base material layer;
covering the anesthetic solution on the surface of the absorption material layer by injection, spraying or misting; realize the application of disinfection and anesthesia.
In a third aspect, the invention provides an application of a medical application with an anesthetic effect, which comprises the following specific processes:
soaking the absorbing material layer in disinfectant solution until the absorbing material layer is saturated in adsorption, and removing moisture to obtain the absorbing material layer adsorbed with the solid disinfectant;
uniformly distributing anesthetic solution on the upper surface of the absorption material layer adsorbed with the solid disinfectant in a coating or infiltrating or spraying manner, and removing water to obtain the absorption material layer with anesthetic adsorbed on the surface layer;
coating the absorbing material layer to prepare a medical application;
when in use, the stripping protective layer of the medical application is removed, and the medical application is applied to the affected part through the base material layer;
the dissolved solution of the anesthetic is covered on the surface of the absorption material layer in the modes of injection, spraying or mist spraying and the like, and the anesthetic is dissolved and actively diffused, so that the application of disinfection and anesthesia is realized.
In a fourth aspect, the invention provides an application of a medical application with an anesthetic effect, which comprises the following specific processes:
loading a disinfectant solution in the medicine-carrying sac and then spreading the disinfectant solution on the surface layer of the absorption material to obtain a disinfectant-carrying absorption material layer;
coating the absorbing material layer to prepare a medical application;
when in use, the stripping protective layer of the medical application is removed, the medicine carrying bag is damaged by extrusion, so that the disinfectant solution is absorbed and absorbed in the material, and the medical application is applied to the affected part through the base material layer;
covering the anesthetic solution on the surface of the absorption material layer by injection, spraying or misting; realize the application of disinfection and anesthesia.
Further, the dissolving solution is an ethanol solution with the concentration of 25-99.5%. Further, the dissolving solution is an ethanol solution with the concentration of 25-50%, 40-50%, 50-60%, 70-75%, 95% or 99.5%.
In the present invention, "anesthesia" means the administration of an anesthetic compound for the purpose of tissue perception and/or reduction of pain, such as: the anesthetic can penetrate into the tissue to a sufficient depth to achieve either topical anesthesia of the skin or anesthesia of the targeted nerves and nerve branches.
The anesthetic and disinfectant in the patch of the present invention are positioned at different parts of the patch, and auxiliary materials containing mutually incompatible active ingredients are prepared, for example, in an absorption substrate layer contained in the disinfectant, the anesthetic is separately packaged (injected to the surface layer of the absorption substrate layer in use) or contained in the surface layer of the absorption substrate layer; the skin surface is reached from the same application in different ways.
The patch of the present invention contains at least a disinfectant and an anesthetic, either simultaneously or sequentially in the absorbent substrate layer, either completely or primarily in the absorbent substrate layer of the patch. The disinfectant is mainly or completely arranged in the absorption basal layer, the anesthetic is mainly or completely arranged on the surface layer of the absorption basal layer, and the disinfectant enters the absorption basal layer through active diffusion, so that two different active ingredients are sequentially transferred to the skin. The two active substances applied to the skin of the invention have different mechanisms of transferring to the skin, and the disinfectant is transferred to the skin surface through passive administration of moisture, blood, secretion and the like contacting the skin surface under the condition of lacking moisture; the active ingredient of the anesthetic permeates from the top layer of the absorption base layer to the skin surface by active administration.
The absorbent substrate layer of the patch of the present invention serves to deliver at least one component to the skin (e.g., a planned surgical site or a wound site) in a passive administration mode, which means that an active substance (e.g., a disinfectant or anesthetic) present in the absorbent substrate layer migrates to the skin surface by dissolving with skin secretions, blood, moisture, etc. in the absence of moisture.
The active ingredient in the absorption substrate layer of the patch of the present invention is released for active administration, which means that the active substance attached to the patch actively diffuses to the skin surface only by contacting the skin in the absence of moisture to thereby achieve the effect.
Compared with the prior art, the invention has the following beneficial effects:
(1) the invention provides a medical application with an anesthesia effect aiming at infection risks possibly brought by separate steps of disinfection and anesthesia in the surgical clinical application process. The application of the invention combines the disinfectant and the anesthetic for use, thereby effectively avoiding the clinical infection risk, and meanwhile, the application of the invention can be used before, after and in the operation, thereby not only facilitating the fussy operation of the clinical doctor, but also improving the compliance of the patient, reducing the pain of the patient and simultaneously reducing the infection probability in the surgical clinical application.
(2) The disinfectant in the medical application can disinfect the skin surface under the action of secretion, blood, moisture and the like on the skin surface; the anesthetic in the medical application can reach the cortex or subcutaneous layer when being applied to the surface of the skin, and can achieve the anesthetic effect of the cortex by gathering at the pain receptor and nerve endings of the cortex, and the anesthetic effect is greatly dependent on the use time of the application and the dosage of the added anesthetic. Compared with the defects of the existing surgical clinical application, the invention can perform anesthesia in the disinfection process, has quick response time, reduces the exposure time of the wound and is simple to operate.
(3) The medical application is simple to operate and good in time period, improves the adaptability of patients, can achieve the effects of disinfection and anesthesia, can immediately treat adverse reactions in the application process, and timely prevents more serious adverse reactions from occurring.
Drawings
Fig. 1 is a schematic structural view of a first Chinese medical application body in embodiment 1 of the product of the invention.
Fig. 2 is a schematic structural view of the inner side of the base material layer in embodiment 1 of the product of the present invention.
Fig. 3 is a schematic structural view of the outer side of the base material layer in embodiment 1 of the product of the present invention.
FIG. 4 is a cross-sectional view of a first medical dressing body according to example 1 of the product of the present invention.
FIG. 5 is a graph showing the pressure value applied to the lower arm measured by a pain meter after using a conventional medical dressing and a medical dressing prepared in example 1 of the present invention, as compared with the change with time.
Detailed Description
The invention is further illustrated with reference to specific examples. It should be understood that the specific embodiments described herein are illustrative only and are not limiting upon the scope of the invention.
The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or instruments used are conventional products which are not known to manufacturers and are available from normal sources.
The experimental procedures in the following examples are conventional unless otherwise specified. The test materials used in the following examples are all commercially available products unless otherwise specified.
Product example 1
As shown in fig. 1 to 4, the present invention provides a medical dressing composition comprising an anesthetic and a disinfectant,
comprises a medical application body I loaded with disinfectant and anesthetic packaged independently;
the medical application body I of the invention comprises:
a base material layer 1;
a peel protective layer 2 bonded to the base material layer 1 at a peripheral portion;
and an absorbent substrate layer 3 between the peel-off protection layer 2 and the substrate material layer 1.
The base material layer 1 is prepared by coating medical pressure-sensitive adhesive on a material with high moisture and air permeability as a base material, wherein the base material comprises but is not limited to non-woven fabrics, gauze, polyurethane composite films, cotton cloth, silk and the like; the base material layer 1 is provided with a hole 11 for injection and a channel 12 radiating with the hole as the center; the channels 12 are arranged on the side of the base material layer 1 facing the absorbing base layer 3; the channels 12 are formed by discontinuous coatings of medical pressure sensitive adhesive, and the solution between the channels can be quickly distributed on the surface of the absorption substrate layer 3 in a penetrating way. The distance between the channels can be equally spaced, the arrangement rule can be regular or irregular, and no special limitation is provided, so long as the rapid permeation and distribution of the solution in the channels can be realized, which is the protection scope of the present application. The medical pressure-sensitive adhesive can be coated by printing, spraying, reverse roll coating, extrusion coating, scraper coating and the like.
The peeling protective layer 2 is a release film or paper coated with a silicone oil anti-sticking agent, and the peeling protective layer is torn off during use, so that the medical application body I can be attached to the skin of a human body.
The absorbent substrate layer 3 comprises an absorbent material layer 31 and a release film 32 attached to the side of the absorbent material layer facing the release-preventing layer 2. The isolating membrane can be a porous polyethylene film, a net or a grid mesh and other materials with high permeability. The absorption base layer 3 comprises an absorption material layer 31 formed by one or two of viscose, acetate, cuprammonium, polyester, polypropylene, polyvinyl chloride or polyester fiber and a polyethylene isolating film attached to one side of the absorption material layer facing the stripping protective layer 2; the absorption substrate layer is high in fit degree with the skin; the active ingredients in the patch can be contacted with the skin, and secretion, water, blood and the like on the surface of the skin can rapidly enter the patch.
The absorbent material layer 31 is loaded with a disinfectant. The preparation process of the absorbing material loaded disinfectant comprises the following steps: and soaking the absorbing material in disinfectant solution, taking out the absorbing material after adsorption saturation, and removing moisture to obtain the absorbing material loaded with the disinfectant. Further, the moisture removing means includes: oven drying, freeze drying, air drying, etc.
The base material layer 1 and the isolation film 32 form a cavity, and the absorption material layer 31 is positioned in the cavities of the base material layer and the isolation film; the substrate material layer 1 is connected with the isolating film 32 in a bonding mode, a pressing mode and the like; the area of the base material layer 1 is slightly larger than that of the isolation film 32; the periphery of the base material layer 1 is provided with a fixing band 11, and the fixing band 13 adopts a magic tape adhesion structure and is positioned at the same position of two opposite sides of the base material layer 1; an elastic band 131 may be disposed in the middle of the fixing band 13, for example, to adjust the size of the fixing band to facilitate the absorption substrate layer to approach the skin surface; the fastening strap 13 on the same side is provided with a hook and loop fastening surface 132, and the fastening strap 13 on the same side is provided with a hook and loop fastening surface 133.
The edge of the stripping protective layer covers the edge of the base material layer, and the sterile environment of the medical application is realized before use.
Product example 2
Essentially identical to product example 1, except that: the medical application combination product containing the anesthetic and the disinfectant comprises a second medical application body loaded with the disinfectant and the anesthetic and a dissolving solution of the anesthetic; the second medical application body of the invention comprises:
a base material layer 1;
a peel protective layer 2 bonded to the base material layer 1 at a peripheral portion;
and an absorbent substrate layer 3 between the peel-off protection layer 2 and the substrate material layer 1.
The absorbent material layer 3 is loaded with a disinfectant and an anesthetic. The preparation process of the absorbing material loaded with the disinfectant and the anesthetic comprises the following steps: soaking the absorbing material in disinfectant solution, taking out the absorbing material after adsorption saturation to remove moisture, and obtaining the absorbing material loaded with the disinfectant; and uniformly distributing the anesthetic solution on the surface of the disinfectant-loaded absorbing material, and removing moisture to obtain the disinfectant-loaded and anesthetic-loaded absorbing material. Further, the moisture removing means includes: oven drying, freeze drying, air drying, etc. Further, the uniform distribution manner includes coating or soaking or spraying, etc.
Product example 3
Essentially identical to product example 1, except that: the preparation process of the disinfectant loaded on the absorbing material layer is as follows: and loading the disinfectant solution in the medicine carrying sac and then spreading the medicine carrying sac on the surface layer of the absorption material to obtain the absorption material layer loaded with the disinfectant.
Application example 1
The invention provides application of a medical application with an anesthesia effect, which comprises the following specific processes:
soaking the absorbing material layer in disinfectant solution until the absorbing material layer is adsorbed to saturation, and drying the absorbing material layer by using an oven or other drying instruments to remove moisture to obtain the absorbing material layer adsorbed with the solid disinfectant;
coating the absorbing material layer to prepare a medical application;
in the clinical use of surgery, the stripping protective layer of the medical application is removed, and the medical application is applied to the affected part through the base material layer;
according to the individual condition of a patient, the anesthetic solution is covered on the surface of the absorbing material layer by injection, spraying or misting; the application of disinfection and anesthesia is realized, and the related preoperative or postoperative and other clinical applications can be carried out after the anesthesia effect is achieved.
Application example 2
The invention provides application of a medical application with an anesthesia effect, which comprises the following specific processes:
soaking the absorbing material layer in disinfectant solution until the absorbing material layer is adsorbed to saturation, and drying the absorbing material layer by using an oven or other drying instruments to remove moisture to obtain the absorbing material layer adsorbed with the solid disinfectant;
uniformly distributing anesthetic solution on the upper surface of the absorption material layer adsorbed with the solid disinfectant in a coating or infiltrating or spraying manner, and removing water to obtain the absorption material layer with anesthetic adsorbed on the surface layer;
coating the absorbing material layer to prepare a medical application;
in the clinical use of surgery, the stripping protective layer of the medical application is removed, and the medical application is applied to the affected part through the base material layer;
the dissolved solution of the anesthetic (such as 50% ethanol solution) is covered on the surface of the absorbing material layer by injection or spraying or atomizing, the anesthetic is dissolved and actively diffused, the application of disinfection and anesthesia is realized, and the related preoperative or postoperative and other clinical applications can be carried out after the anesthetic effect is achieved.
Application example 3
The invention provides application of a medical application with an anesthesia effect, which comprises the following specific processes:
loading a disinfectant solution in the medicine-carrying sac and then spreading the disinfectant solution on the surface layer of the absorption material to obtain a disinfectant-carrying absorption material layer;
coating the absorbing material layer to prepare a medical application;
when in surgical clinical use, the stripping protective layer of the medical application is removed, the damaged medicine carrying bag is squeezed, so that the disinfectant solution is absorbed in the absorbing material, and the medical application is applied to an affected part through the base material layer;
covering the anesthetic solution on the surface of the absorption material layer by injection, spraying or misting; realize the application of disinfection and anesthesia.
Detailed description of the invention example 1
Adding 30mL of sterile water into 70mL of commercially available benzalkonium bromide solution, fully and uniformly mixing, and preparing benzalkonium bromide disinfectant with the volume ratio of 70%;
soaking the absorbing material layer in the benzalkonium bromide disinfectant for 2h, taking out, and drying in an oven to obtain a water absorbing pad with disinfecting effect;
coating the absorbing material layer to prepare a medical application;
dissolving 0.75g of commercially available bupivacaine in 10mL of 50% ethanol solution until the concentration of the bupivacaine is 7.5%, uniformly mixing and packaging for later use;
in the clinical use of surgery, the stripping protective layer of the medical application is removed, and the medical application is applied to the affected part through the base material layer;
according to the individual condition of a patient, sucking a proper amount of bupivacaine solution by using an injector to inject and cover the surface of the absorption material layer; the application of disinfection and anesthesia is realized, and the related preoperative or postoperative and other clinical applications can be carried out after the anesthesia effect is achieved.
Detailed description of the invention example 2
Adding 30mL of sterile water into 70mL of commercially available benzalkonium chloride solution, fully and uniformly mixing, and preparing benzalkonium chloride disinfectant with the volume ratio of 70%;
soaking the absorbing material layer in the benzalkonium chloride disinfectant for 2h, taking out, and drying in an oven to obtain a water absorbing pad with disinfecting effect;
coating the absorbing material layer to prepare a medical application;
dissolving 0.75g of commercially available lidocaine in 10mL of 50% ethanol solution until the concentration of the lidocaine is 7.5%, uniformly mixing, and packaging for later use;
in the clinical use of surgery, the stripping protective layer of the medical application is removed, and the medical application is applied to the affected part through the base material layer;
according to the individual condition of a patient, sucking a proper amount of bupivacaine solution by using an injector to inject and cover the surface of the absorption material layer; the application of disinfection and anesthesia is realized, and the related preoperative or postoperative and other clinical applications can be carried out after the anesthesia effect is achieved.
Detailed description of the preferred embodiments example 3
Adding 30mL of sterile water into 70mL of commercially available benzalkonium bromide solution, fully and uniformly mixing, and preparing benzalkonium bromide disinfectant with the volume ratio of 70%;
soaking the absorbing material layer in the benzalkonium bromide disinfectant for 2h, taking out, and drying in an oven to obtain a water absorbing pad with disinfecting effect;
uniformly distributing 0.75g of a commercially available bupivacaine solution on the surface of the disinfectant-loaded absorbing material, and removing moisture to obtain the disinfectant-and-anesthetic-loaded absorbing material;
coating the absorbing material layer to prepare a medical application;
in the clinical use of surgery, the stripping protective layer of the medical application is removed, and the medical application is applied to the affected part through the base material layer;
the 10mL of 50% ethanol solution is injected to cover the surface layer of the absorption material layer, the anesthetic is dissolved and actively diffused, the application of disinfection and anesthesia is realized, and the related preoperative or postoperative and other clinical applications can be carried out after the anesthetic effect is achieved.
Specific product example 4
Adding 30mL of sterile water into 70mL of benzalkonium bromide solution, fully and uniformly mixing, preparing benzalkonium bromide disinfectant with volume ratio of 70%, and filling into a medicine carrying bag;
spreading the medicine-carrying sac on the surface layer of the absorbing material to obtain a disinfectant-carrying absorbing material layer;
coating the absorbing material layer to prepare a medical application;
dissolving 0.75g of bupivacaine in 10mL of 50% ethanol solution to ensure that the concentration of the bupivacaine is 7.5%, uniformly mixing and packaging for later use;
in the clinical use of surgery, the stripping protective layer of the medical application is removed, and the medical application is applied to the affected part through the base material layer;
according to the individual condition of a patient, sucking a proper amount of bupivacaine solution by using an injector to inject and cover the surface of the absorption material layer; the application of disinfection and anesthesia is realized, and the related preoperative or postoperative and other clinical applications can be carried out after the anesthesia effect is achieved.
Specific product example 5
Adding 30mL of sterile water into 70mL of commercially available benzalkonium chloride solution, fully and uniformly mixing, and preparing benzalkonium chloride disinfectant with the volume ratio of 70%;
soaking the absorbing material layer in the benzalkonium chloride disinfectant for 2 hr, and drying in a drying oven to obtain a water absorbing pad with disinfecting effect;
uniformly distributing 0.75g of commercially available procaine solution on the surface of the disinfectant-loaded absorbing material, and removing moisture to obtain the disinfectant-and anesthetic-loaded absorbing material;
coating the absorbing material layer to prepare a medical application;
in the clinical use of surgery, the stripping protective layer of the medical application is removed, and the medical application is applied to the affected part through the base material layer;
the 10mL of 50% ethanol solution is injected to cover the surface layer of the absorption material layer, the anesthetic is dissolved and actively diffused, the application of disinfection and anesthesia is realized, and the related preoperative or postoperative and other clinical applications can be carried out after the anesthetic effect is achieved.
Effects of the embodiment
And (3) disinfection detection:cleaning with clear water before skin disinfection, wipingSpecific product example 1 preparationAfter 5 minutes of application, the patch was sampled and examined. The detection result shows that: compared with the conventional iodine tincture and alcohol, the antibacterial ratio of the patch of the invention is improved from original 95% to 99.9%, pathogenic bacteria propagules such as candida albicans, escherichia coli, staphylococcus aureus and the like are not detected, and the patch can continuously sterilize and disinfect without corrosiveness.
The application prepared by the invention has reasonable sterilization and disinfection effects, and the result proves that the mode of loading the solid disinfectant in the process of preparing the application can not reduce the activity of effective active ingredients contained in the application. The disinfectant in the patch prepared by the invention is still completely effective, can reach the surface of the skin to take effect, has completely consistent or even better effect compared with the prior art in which disinfectant solution is directly adopted for disinfection, and has more advantages that: the application of the invention does not need to expose the wound, and can effectively reduce the infection probability.
Anesthesia detection:
and (3) contrasting the operation process: selecting the flat part of the forearm of the testee, disinfecting the lower arm with an alcohol cotton ball, then sticking the lower arm to the flat part with a common medical application, and performing corresponding pressure pain tests with a pain meter at different time points (0 min, 5min, 10 min and 15min) respectively. When the test subjects felt pain or the pain was intolerable, pressure values on the pain meter were recorded.
The anesthesia detection operation process comprises the following steps: similar to the control procedure except that: the common medical application is changed into the inventionSpecific product example 1 preparationThe medical application was attached to the forearm and a corresponding pressure pain test was performed with a pain gauge at the same application site at the same time point during the control procedure. When the test subjects felt pain or the pain was intolerable, pressure values on the pain meter were recorded.
Comparing the two different medical application effects and measuring the change of the pressure value of the pain.
And (4) conclusion: as can be seen from the comparison of the pressure value change shown in FIG. 5, the medical patch prepared by the invention can rapidly achieve the effects of disinfection and anesthesia in a short time, and can bear higher pain pressure than the common medical patch.
The medical application prepared by the invention has reasonable anesthetic effect, and the result proves that the anesthetic effect of the active ingredient of the application prepared by the invention is not reduced in clinical application, the anesthetic effect takes effect in a short time in the using process, the effect can be taken on the surface of a wound or skin quickly, the wound does not need to be exposed, and the infection risk can be effectively reduced. More importantly, in the using process, if anesthesia risks occur, the patch can be directly taken down, and damage can be stopped in time.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (10)
1. A product comprising an anesthetic and a disinfectant, characterized in that the disinfectant anesthetic is used separately, simultaneously or sequentially as a combined preparation for a surgical clinical application procedure;
the product comprising an anesthetic and a disinfectant is administered transdermally.
2. A product containing an anaesthetic and disinfectant according to claim 1 characterised in that the disinfectant has an active component selected from one or more of bis-quaternary TS-838, octadecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium bromide, cetylpyridinium chloride, benzalkonium bromide, benzalkonium chloride, dodecyl dimethyl phenoxyethyl ammonium bromide;
the anesthetic is administered by injection;
the active component in the anesthetic is selected from one of procaine, benzocaine, butamben, dibucaine, lidocaine, mepivacaine, dyclonine, bupivacaine, etidocaine, prilocaine, ropivacaine, oxybuprocaine, pramoxine, proparacaine, proxymetacaine, novocaine and tetracaine.
3. The anesthetic and disinfectant containing product according to claim 1, characterized in that said anesthetic and disinfectant containing product is a medical application combination product containing anesthetic and disinfectant.
4. The product containing anesthetic and disinfectant as set forth in claim 3, wherein the medical application combination product containing anesthetic and disinfectant includes a first medical application body loaded with disinfectant and anesthetic packaged separately, or a second medical application body loaded with disinfectant and anesthetic simultaneously;
the first medical application body and the second medical application body independently comprise:
a base material layer;
a peel-off protective layer adhered to the base material layer at a peripheral portion;
and an absorbent substrate layer between the peel-off protection layer and the substrate material layer.
5. The product containing anesthetic and disinfectant according to claim 4, characterized in that said base material layer is made of a base material coated with a medical pressure sensitive adhesive;
the substrate material layer is provided with a hole for injection and a channel radiating with the hole as a center; the channel is arranged on one side of the substrate material layer facing the absorption substrate layer; the channel is formed by a discontinuous coating of medical pressure-sensitive adhesive;
the stripping protective layer is a release film or paper coated with a silicone oil anti-sticking agent.
6. A product containing an anesthetic and disinfectant according to claim 4, characterized in that the absorbent substrate layer comprises a layer of absorbent material and a barrier film attached to the side of the layer of absorbent material facing the peel-off protection layer.
7. A product containing an anaesthetic and disinfectant agent as claimed in claim 6 wherein the absorbent material layer is loaded with a disinfectant agent; the preparation process of the disinfectant loaded on the absorbing material layer is as follows: soaking the absorbing material in disinfectant solution, taking out the absorbing material after adsorption saturation to remove moisture, and obtaining an absorbing material layer loaded with disinfectant; or the disinfectant loaded on the absorbing material layer is prepared by the following steps: loading the disinfectant solution in a medicine-carrying sac and then spreading the disinfectant solution on the surface layer of an absorption material to obtain a disinfectant-carrying absorption material layer;
or,
the absorption material layer is loaded with disinfectant and anesthetic; the preparation process of the absorbing material layer loaded with the disinfectant and the anesthetic comprises the following steps: soaking the absorbing material in disinfectant solution, taking out the absorbing material after adsorption saturation to remove moisture, and obtaining the absorbing material loaded with the disinfectant; and uniformly distributing the anesthetic solution on the surface of the disinfectant-loaded absorbing material, and removing moisture to obtain a disinfectant-and anesthetic-loaded absorbing material layer.
8. A product containing an anaesthetic and disinfectant agent as claimed in claim 6 wherein the base material layer forms a cavity with the barrier material, the absorbent material layer being located within the cavity of both; the periphery of the base material layer is provided with a fixing belt;
the edge of the stripping protective layer covers the edge of the base material layer.
9. The application of the medical application with anesthetic effect as claimed in any one of claims 1-8, which is characterized in that the specific process is as follows:
soaking the absorbing material layer in disinfectant solution until the absorbing material layer is saturated in adsorption, and removing moisture to obtain the absorbing material layer adsorbed with the solid disinfectant; or loading the disinfectant solution into the medicine carrying bag, spreading the medicine carrying bag on the surface layer of the absorption material, and extruding the damaged medicine carrying bag before use to enable the disinfectant solution to be adsorbed into the absorption material to obtain an absorption material layer loaded with the disinfectant;
coating the absorbing material layer to prepare a medical application;
when in use, the stripping protective layer of the medical application is removed, and the medical application is applied to the affected part through the base material layer;
covering anesthetic solution on the surface of the absorption material layer; the application of disinfection and anesthesia is realized;
or,
soaking the absorbing material layer in disinfectant solution until the absorbing material layer is saturated in adsorption, and removing moisture to obtain the absorbing material layer adsorbed with the solid disinfectant;
uniformly distributing anesthetic solution on the upper surface of the absorption material layer adsorbed with the solid disinfectant in a coating or infiltrating or spraying manner, and removing water to obtain the absorption material layer with anesthetic adsorbed on the surface layer;
coating the absorbing material layer to prepare a medical application;
when in use, the stripping protective layer of the medical application is removed, and the medical application is applied to the affected part through the base material layer;
the dissolved solution of the anesthetic is covered on the surface of the absorption material layer, and the anesthetic is dissolved and actively diffused, so that the application of disinfection and anesthesia is realized.
10. Use of a medical dressing having an anaesthetic effect according to claim 9 characterised in that the means of covering the surface of the absorbent material layer comprises one or more of injection, spraying or misting;
the dissolving solution is an ethanol solution with the concentration of 25-99.5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111023208.1A CN113616626A (en) | 2021-09-01 | 2021-09-01 | Medical application with anesthesia effect and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111023208.1A CN113616626A (en) | 2021-09-01 | 2021-09-01 | Medical application with anesthesia effect and application thereof |
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| Publication Number | Publication Date |
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| CN113616626A true CN113616626A (en) | 2021-11-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202111023208.1A Pending CN113616626A (en) | 2021-09-01 | 2021-09-01 | Medical application with anesthesia effect and application thereof |
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Application publication date: 20211109 |