CN113576710A - Artificial bionic blood vessel and manufacturing method thereof - Google Patents
Artificial bionic blood vessel and manufacturing method thereof Download PDFInfo
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- CN113576710A CN113576710A CN202110953090.6A CN202110953090A CN113576710A CN 113576710 A CN113576710 A CN 113576710A CN 202110953090 A CN202110953090 A CN 202110953090A CN 113576710 A CN113576710 A CN 113576710A
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- 239000011664 nicotinic acid Substances 0.000 title claims abstract description 34
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 39
- 239000000741 silica gel Substances 0.000 claims abstract description 39
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 39
- 239000007788 liquid Substances 0.000 claims abstract description 29
- 239000002729 catgut Substances 0.000 claims abstract description 11
- 239000004519 grease Substances 0.000 claims description 16
- 241001465754 Metazoa Species 0.000 claims description 10
- 230000003592 biomimetic effect Effects 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
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- 238000010276 construction Methods 0.000 claims description 6
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- 239000002904 solvent Substances 0.000 claims description 5
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- 239000010410 layer Substances 0.000 description 61
- 239000002473 artificial blood Substances 0.000 description 11
- 208000007536 Thrombosis Diseases 0.000 description 7
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- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides an artificial bionic blood vessel and a manufacturing method thereof, the artificial bionic blood vessel comprises an artificial bionic blood vessel body with a three-layer structure, wherein the three-layer structure of the artificial bionic blood vessel comprises a natural silk layer, a diluted liquid silica gel layer and a woven tube layer, the diluted liquid silica gel layer is positioned on the inner side of the natural silk layer, the woven tube layer is positioned on the outer side of the natural silk layer, and the woven tube layer is woven by catgut threads.
Description
Technical Field
The invention belongs to the technical field of artificial blood vessels, and particularly relates to an artificial bionic blood vessel and a manufacturing method thereof.
Background
In recent years, various cardiovascular diseases seriously endanger human health, and the blood vessel transplantation is receiving more and more attention. The best choice for vascular grafting is to use autologous blood vessels, however, due to the limited source, the demand for vascular grafting has not been met. In this case, the use of artificial blood vessels becomes a good choice.
The artificial blood vessel in the prior art is mainly made of polytetrafluoroethylene or polyester fiber braided fabric, careful suturing is needed during operation, and an anastomotic stoma is easy to form stenosis and thrombus, particularly the probability that the artificial blood vessel with small inner diameter forms stenosis and thrombus is high; in addition, the artificial blood vessel is easy to break when turning, the inner diameter of the artificial blood vessel is changed, and the blood flow is not smooth; meanwhile, the traditional artificial blood vessel cannot be well absorbed by regenerated blood vessels in the actual use process, so that the probability of thrombosis is further increased.
Disclosure of Invention
The invention aims to provide an artificial bionic blood vessel and a manufacturing method thereof, aiming at solving the problems that the artificial blood vessel in the prior art is mainly made of polytetrafluoroethylene or polyester fiber braided fabric, needs to be carefully sutured during operation, and an anastomotic stoma is easy to form stenosis and thrombus, particularly the probability that the artificial blood vessel with small inner diameter forms stenosis and thrombus is high; in addition, the artificial blood vessel is easy to be broken when turning, the inner diameter of the artificial blood vessel is changed, and the blood flow is not smooth.
In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides an artificial bionic blood vessel, includes three layer construction's artificial bionic blood vessel body, wherein artificial bionic blood vessel's three layer construction is natural silk layer, dilutes liquid silica gel layer and woven tube layer respectively, dilutes the inboard that liquid silica gel layer is located natural silk layer, and woven tube layer is located the outside on natural silk layer, woven tube layer is woven by the catgut and is made.
Preferably, the surface of the braided tube layer is provided with double-spiral protrusions.
Preferably, the ends of the natural silk layer, the diluted liquid silica gel layer and the woven tube layer are provided with oval bulges, and a ring-shaped interface with a slightly bulged middle part is formed by the three oval bulges.
Preferably, the ring-shaped interface is made of silica gel grease or animal grease.
Preferably, the surface of the woven tube layer and the surface of the loop interface are coated with fish skin glue oligopeptide subjected to liquid treatment.
A method for manufacturing an artificial bionic blood vessel comprises the following steps of:
s1, selecting natural silk with the diameter of 5-10 μm, sterilizing, and weaving to form a natural silk layer;
s2, selecting liquid silica gel, diluting to form a silica gel solvent, and finally solidifying and adsorbing the silica gel solvent on the inner side of the natural silk layer to form a diluted liquid silica gel layer;
s3, selecting catgut with the diameter less than 40 mu m to weave a seamless tubular structure, and fixing the tubular structure outside the natural silk layer to form a woven tube layer;
and S4, preparing a ring-shaped interface by using silica gel grease or animal grease.
Preferably, in the step S1, the gaps of the natural silk layer are filled with gel which can be absorbed by human body.
Preferably, the woven tube layer in the step S3 and the loop interface in the step S4 are coated with a blood vessel anastomosis adhesive when used for blood vessel connection.
Compared with the prior art, the invention has the beneficial effects that:
1) the natural silk layer woven by natural silk can form a protective layer, so that the primary regenerated blood vessel and the diluted liquid silica gel layer can not generate mutual exclusion effect, the complete smoothness of the inner wall of the diluted liquid silica gel layer is ensured, the blockage is avoided, in addition, the double-spiral bulge is arranged, the toughness and the elasticity of the artificial bionic blood vessel can be increased, the inner wall is prevented from being adhered after being implanted into a body, and the formation of thrombus is further prevented;
2) the artificial bionic blood vessel mainly comprises animal tissues and natural organisms, does not generate side effects on body functions, is easy to absorb by a body, has the function of promoting blood vessel regeneration by distributing the fish skin glue oligopeptide coating at joints of the bionic blood vessel and the blood vessel, has the outermost layer of a superfine catgut braided tubular shape, and can be absorbed and covered by regenerated blood vessels after a period of time;
3) the ring-shaped interface made of silica gel lubricating grease or animal grease arranged at the joint of the artificial bionic blood vessel can be directly adsorbed with the primary blood vessel, so that suturing is avoided as much as possible;
4) the fish skin glue oligopeptide can be completely absorbed by catgut after liquid treatment, and provides a nutrient source to promote the growth of primary blood vessels when the primary blood vessels grow again.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of a tube structure according to the present invention;
FIG. 3 is a cross-sectional view of FIG. 2 of the present invention;
FIG. 4 is a schematic view of a bump structure according to the present invention;
FIG. 5 is a schematic structural diagram of embodiment 2 of the present invention;
FIG. 6 is an electron microscope image of the artificial bionic blood vessel of the present invention after 18 months of living body transplantation;
fig. 7 is a sectional view of the artificial biomimetic blood vessel of the present invention after 18 months of in vivo transplantation.
In the figure: 1. a natural silk layer; 2. diluting the liquid silica gel layer; 3. weaving a tube layer; 31. a protrusion; 4. a ring-shaped interface; 5. a flap interface.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
Referring to fig. 1-4, the present invention provides the following technical solutions: the utility model provides an artificial bionic blood vessel, includes three layer construction's artificial bionic blood vessel body, and wherein artificial bionic blood vessel's three layer construction is natural silk layer 1, dilutent liquid silica gel layer 2 and woven tube layer 3 respectively, and dilutent liquid silica gel layer 2 is located the inboard on natural silk layer 1, and woven tube layer 3 is located the outside on natural silk layer 1, and woven tube layer 3 is woven by the catgut and is made.
In this embodiment: the surface of woven tube layer 3 is equipped with two heliciform arch 31, and the whole toughness and the elastic property of bionical blood vessel body can be increased to the two heliciform arch 31 that wherein set up for bionical blood vessel has better resilience when being applied to the blood vessel grafting of joint department, avoids the atress back inboard pipe wall to take place the adhesion and arouse vascular jam, and of course, also can be according to the in-service use needs, and arch 31's shape also can be strip circle form etc..
In this embodiment: the ends of the natural silk layer 1, the diluted liquid silica gel layer 2 and the woven tube layer 3 are provided with elliptical bulges, the three elliptical bulges form a ring-shaped interface 4 with a slightly-bulged middle part, the ring-shaped interface 4 is made of silica gel lubricating grease or animal grease, animal tissues and natural organisms are adopted to form the artificial silk layer, side effects on body functions cannot be generated, the artificial silk layer is easily absorbed by a body, raw materials are obtained simply, and the manufacturing cost of artificial bionic blood vessels can be reduced to a certain extent.
In this embodiment: the fish skin glue oligopeptide which is subjected to liquid treatment is smeared on the surface of the woven tube layer 3 and the surface of the ring-shaped interface 4, and the fish skin glue oligopeptide can be completely absorbed by catgut after liquid treatment, so that a nutrient source is provided when primary blood vessels grow again, and the primary blood vessels can grow better.
Example 2
Referring to fig. 5, the ends of the natural silk layer 1, the diluted liquid silica gel layer 2 and the woven tube layer 3 are all provided with a flap-shaped sheet, and a plurality of flap-shaped sheets form a flap-shaped interface 5, so that the artificial bionic blood vessel can be better connected with the native blood vessel, and the risks of intimal hyperplasia and anastomotic stenosis of the anastomotic stoma are reduced.
A method for manufacturing an artificial bionic blood vessel comprises the following steps of:
s1, selecting natural silk with the diameter of 5-10 μm, sterilizing, weaving to form a natural silk layer 1, selecting natural mulberry silk, rolling into a cylinder by weaving technology, weaving silk with different properties outside to serve as a protective layer, preventing blood leakage, enabling the diameter of the artificial bionic blood vessel to be 1 mm, preventing thrombus from forming, enabling protein components of the artificial bionic blood vessel to be compatible with internal tissues, being very practical for young patients needing to replace the blood vessel, filling gel capable of being absorbed by human bodies in gaps of the natural silk layer 1, further preventing the artificial bionic blood vessel from being connected into the body to cause blood leakage, and enabling the finally prepared tube to be softer and closer to the flexibility of the original blood vessel compared with artificial compounds such as polyester fiber and the like;
s2, selecting liquid silica gel to form a silica gel solvent after dilution, and finally solidifying and adsorbing the silica gel to the inner side of the natural silk layer 1 to form a diluted liquid silica gel layer 2, adopting high-purity double-component room-temperature silica gel as a basic raw material, and adopting the liquid silica gel which is catalyzed by platinum or peroxide, wherein the liquid silica gel layer is nontoxic, odorless, physiologically inert, biological aging resistant, very small in reaction to human tissues, free of foreign body reaction after being implanted into the human tissues, free of inflammation to surrounding tissues, and capable of further increasing the flexibility of the artificial bionic blood vessel by adopting the diluted liquid silica gel layer 2 as the outermost layer of the artificial bionic blood vessel;
s3, selecting catgut with the diameter less than 40 μm to weave a seamless tubular structure, fixing the tubular structure on the outer side of the natural silk layer 1 to form a woven tube layer 3, and absorbing and covering the catgut woven tube by the regenerated blood vessel after the artificial bionic blood vessel is connected with the blood vessel for a period of time so as to promote the success of the blood vessel implantation treatment;
s4, the ring-shaped interface 4 is made of silica gel grease or animal grease, the vascular anastomosis adhesive is coated on the knitted tube layer 3 and the ring-shaped interface 4 in the step S4 when the knitted tube layer is used for blood vessel connection, and the silica gel grease or the animal grease can be directly adsorbed to the blood vessel to avoid suturing as much as possible.
Specifically, referring to fig. 6 and 7, after the artificial bionic blood vessel of the present invention is transplanted in vivo for 18 months, it can be seen that the inner wall is smooth, and the braided tube layer 3 of the outer wall is gradually absorbed and covered by the regenerated blood vessel, so that the artificial bionic blood vessel of the present invention has a huge market in clinical application.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. An artificial bionic blood vessel, which is characterized in that: including three layer construction's artificial bionic blood vessel body, wherein artificial bionic blood vessel's three layer construction is natural silk layer (1), dilution liquid silica gel layer (2) and woven tube layer (3) respectively, dilution liquid silica gel layer (2) are located the inboard on natural silk layer (1), and woven tube layer (3) are located the outside on natural silk layer (1), woven tube layer (3) are woven by the catgut and are made.
2. The artificial biomimetic blood vessel according to claim 1, wherein: the surface of the braided tube layer (3) is provided with double-spiral bulges (31).
3. The artificial biomimetic blood vessel according to claim 1, wherein: the ends of the natural silk layer (1), the diluted liquid silica gel layer (2) and the woven tube layer (3) are provided with oval bulges, and a ring-shaped interface (4) with a slightly bulged middle part is formed by the three oval bulges.
4. An artificial biomimetic blood vessel as recited in claim 3, wherein: the ring-shaped connector (4) is made of silica gel lubricating grease or animal grease.
5. The artificial biomimetic blood vessel according to claim 1, wherein: and fish skin glue oligopeptide subjected to liquid treatment is coated on the surface of the woven tube layer (3) and the surface of the ring-shaped interface (4).
6. A method for manufacturing an artificial biomimetic blood vessel, comprising manufacturing an artificial biomimetic blood vessel according to any one of claims 1-5, characterized in that: the method specifically comprises the following steps:
s1, selecting natural silk with the diameter of 5-10 μm, sterilizing, and weaving to form a natural silk layer (1);
s2, diluting liquid silica gel to form a silica gel solvent, and finally solidifying and adsorbing the silica gel solvent on the inner side of the natural silk layer (1) to form a diluted liquid silica gel layer (2);
s3, selecting catgut with the diameter less than 40 mu m to weave a seamless tubular structure, and fixing the tubular structure outside the natural silk layer (1) to form a woven tube layer (3);
s4, the ring-shaped interface (4) is made of silica gel grease or animal grease.
7. The method for manufacturing an artificial biomimetic blood vessel according to claim 6, wherein: the gaps of the natural silk layer (1) in the step S1 are filled with gel which can be absorbed by human body.
8. The method for manufacturing an artificial biomimetic blood vessel according to claim 6, wherein: the woven tube layer (3) in the step S3 and the ring-shaped interface (4) in the step S4 are coated with vascular anastomosis adhesive when used for vascular connection.
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| US5697969A (en) * | 1991-03-25 | 1997-12-16 | Meadox Medicals, Inc. | Vascular prosthesis and method of implanting |
| US6136024A (en) * | 1996-12-06 | 2000-10-24 | Yasuhiko Shimizu | Artificial blood vessel |
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