CN113575825A - Solid beverage for aiding sleep and beautifying and preparation method thereof - Google Patents
Solid beverage for aiding sleep and beautifying and preparation method thereof Download PDFInfo
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- CN113575825A CN113575825A CN202110848593.7A CN202110848593A CN113575825A CN 113575825 A CN113575825 A CN 113575825A CN 202110848593 A CN202110848593 A CN 202110848593A CN 113575825 A CN113575825 A CN 113575825A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/10—Coating with edible coatings, e.g. with oils or fats
- A23P20/15—Apparatus or processes for coating with liquid or semi-liquid products
- A23P20/18—Apparatus or processes for coating with liquid or semi-liquid products by spray-coating, fluidised-bed coating or coating by casting
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention discloses a solid beverage for assisting sleep and maintaining beauty, which comprises quick-release pellets and slow-release pellets, wherein the main active ingredients of the quick-release pellets are gamma-aminobutyric acid, theanine and casein peptide, the main active ingredients of the slow-release pellets are gamma-aminobutyric acid, theanine, casein peptide, fish collagen peptide, orange peel enzyme liposome, spina date seed powder and tuckahoe powder, the quick-release pellets are quickly disintegrated after entering a human body and quickly play a sleep-assisting effect, the active ingredients are completely released after the slow-release pellets enter the human body for a period of time, the action time of the sleep-assisting ingredients is effectively prolonged, and other ingredients with the effects of calming and soothing the nerves, maintaining beauty and keeping young and the like are added into the slow-release pellets; the invention can be taken with water, has no problem of residual sweetness of teeth, has extremely small volume and is easy to swallow, and consumers can mix the product into food for taking; the invention also discloses a preparation method of the sleep-aiding and beauty-maintaining solid beverage, which has strong operability and high production efficiency.
Description
Technical Field
The invention belongs to the field of health-care food, and particularly relates to a solid beverage for aiding sleep and beautifying and a preparation method thereof.
Background
According to statistics, the incidence rate of insomnia of adults in China is up to 38.2 percent, namely more than 5 hundred million Chinese people are troubled by sleep disorder, and the insomnia becomes an important factor influencing the health of modern people, so that a plurality of sleep-aiding health-care products appear on the market, the sleep-aiding health-care products are taken by oral liquid, chewing gum, tablets and the like, and the effective sleep-aiding component is usually melatonin or gamma-aminobutyric acid.
The applicant finds that the sleep-aiding products have the following defects through a large amount of market research:
firstly, the taking mode is insufficient, the chewing soft sweet is not suitable for consumers who do not like to eat sweet, and a considerable part of consumers can not sleep after getting on bed for a period of time to take the chewing soft sweet, so that the chewing soft sweet can cause residual sweet taste on teeth, and the consumers need to brush teeth again; in the form of oral liquid, the active ingredients are directly contacted with the tongue, the oral liquid needs to pay special attention to the problem of antisepsis, the proportion of the preservative is large, so that more sugar ingredients are added to cover the bitter taste of the active ingredients and the preservative, the taste is poor, and the problem of residual sweet taste on teeth caused by taking the oral liquid is also caused; the compressed tablet form is not comfortable for consumers who are not good at swallowing tablets.
Secondly, the above administration modes are that the active ingredients are taken in at one time, the number of receptors which can act with the active ingredients by human bodies is limited, and the gamma-aminobutyric acid is degraded in the human bodies within about 20-30 minutes, so that part of consumers with severe sleep difficulty are not asleep, the redundant gamma-aminobutyric acid is degraded, the receptors cannot be continuously acted, and the effective duration is limited.
Finally, the effective components and functions of the products are single, so that most consumers are sleepy to sleep as soon as possible, but most of the insomnia consumers are accompanied with emotional problems, facial aging problems and physical function decline problems.
Disclosure of Invention
Aiming at the problems in the related art, the invention provides a solid beverage for aiding sleep and beautifying and a preparation method thereof, so as to overcome the technical problems in the prior related art.
The technical scheme of the invention is realized as follows:
a solid beverage for improving sleep and caring skin comprises quick-release pellets and sustained-release pellets, wherein the main effective components of the quick-release pellets are gamma-aminobutyric acid, theanine and casein peptide, and the main effective components of the sustained-release pellets are gamma-aminobutyric acid, theanine, casein peptide, fish collagen peptide, orange peel enzyme liposome, spina date seed powder and poria cocos powder.
The invention adopts a mode of combining the quick-release pellets and the slow-release pellets, the quick-release pellets are quickly disintegrated after entering a human body, the effective components are released, the sleep-aiding effect is quickly exerted, the effective components are completely released after the slow-release pellets enter the human body for a period of time, and the action time of the sleep-aiding components is effectively prolonged; in addition, the quick-release pellets only contain a sleep-aiding component, so that the quick-release pellets are coated with a sufficient amount of the sleep-aiding component to realize the quick sleep-aiding function, and the slow-release pellets are added with other components with the effects of tranquilizing and allaying excitement, maintaining beauty and keeping young and the like besides the sleep-aiding component.
The gamma-aminobutyric acid is a very important inhibitory neurotransmitter, can activate GABA receptors and further has the effects of soothing nerves, hypnosis and the like; the theanine is an active ingredient inducing sedation, and can regulate neurotransmitter activity, reduce psychological stress and sleep disorders; research shows that compared with single administration, the mixed administration of the gamma-aminobutyric acid and the theanine has positive synergistic effect on the sleep quality and the sleep duration, so that the sleep latency is reduced, and the sleep time is prolonged.
The casein peptide also has the effects of relieving spirit, relieving pressure and helping sleep, and simultaneously stimulates the proliferation of lymphocytes of an organism and improves the resistance of the organism to external pathogens, so that the casein peptide, the gamma-aminobutyric acid and the theanine have synergistic effect, the sleep quality of consumers is ensured, and the immunity of the body is improved. In addition, the casein peptide contains hydrophobic amino acid peptide (bitter peptide) and thus has heavy bitter taste, which is one of the reasons that the invention does not consider to be made into buccal tablets or soft sweets, and the form of the pellet can effectively wrap the casein peptide inside to avoid contacting with taste organs.
Considering that most of insomnia can cause facial problems, the fish collagen is added into the sustained-release pellets, firstly, the fish collagen can repair broken and aged elastic fiber nets, reform skin tissue structures, stretch wrinkles, and remove free radicals in vivo and slow down skin aging, and secondly, the fish collagen can promote skin microcirculation around eyes, strengthen the metabolism of the skin of the eyes and improve the problems of under-eye bags and black eyes; finally, the fish collagen also has a certain sleep-aiding effect, which can assist other sleep-aiding components of the invention.
The orange peel enzyme has the effects of regulating day and night balance, improving sleep and relieving emotion. If the orange peel enzyme is directly taken orally, the enzyme structure of the orange peel enzyme is damaged through digestion of gastric juice, so that the function of the orange peel enzyme is lost, therefore, the orange peel enzyme liposome prepared from the orange peel enzyme liposome keeps the stability of the structure and the activity of the orange peel enzyme, avoids being damaged by the gastric juice, and promotes the absorption of human bodies to the orange peel enzyme.
The traditional sleep-aiding products are mostly prepared by simply adding effective chemical components, and neglecting the condition that the effective chemical components can cooperate with traditional Chinese medicines for conditioning, so that the wild jujube kernel powder and the poria cocos powder are added into the traditional Chinese medicine composition. The compendium of materia medica describes that the spina date seeds are: it is sweet and moist, so it is used to treat insomnia due to gallbladder deficiency, polydipsia and sweating; the formula is called as nontoxic in famous medical records, mainly treats dysphoria with restlessness and insomnia, namely the spina date seed is sweet in taste and mild in nature, can clear deficiency heat of liver and gallbladder, calms heart and tranquilizes mind, and is widely applied to a prescription for calming and relaxing sleep. Shen nong Ben Cao Jing Yi (Shen nong's herbal Jing's reading) describes that Poria is: qi flatly enters lung, the flavor is sweet and enters spleen, the lung can regulate and regulate, and the spleen can transport, namely, the tuckahoe can dredge channels and collaterals, condition the interior of an organism, remove redundant moisture in the body and improve skin metabolism.
The invention can be taken with water, has no problem of residual sweetness of teeth, has extremely small volume and is easy to swallow, and consumers can mix the product into food which is used before sleeping, such as milk, honey water, a small cup of red wine and the like.
Considering that the quick-release pellets only contain the sleep-aiding components, and the slow-release pellets are added with other components with the effects of tranquilizing and allaying excitement, maintaining beauty and keeping young and the like besides the sleep-aiding components, in order to enable the slow-release pellets to release sufficient active components, the ratio of the quick-release pellets to the slow-release pellets is 1: 2-4.
Preferably, the outer diameter of the quick release pellet and the slow release pellet is 0.5-1.5 mm, so that the quick release pellet and the slow release pellet are convenient to swallow.
The quick-release pellets and the sustained-release pellets are provided with a pellet core, a hydrophilic coating and a hydrophobic coating from inside to outside so as to avoid dissolving the quick-release pellets and the sustained-release pellets in the liquid and further releasing bitter taste to influence the mouthfeel because the quick-release pellets and the sustained-release pellets are not required to be provided with the hydrophobic coating considering that a consumer can add the quick-release pellets into the liquid (such as milk and the like) for administration.
The quick-release pellet is provided with a first pellet core, a first hydrophilic coating and a first hydrophobic coating from inside to outside, wherein the first pellet core comprises the following raw materials in parts by weight: 3-10 parts of gamma-aminobutyric acid, 3-10 parts of theanine, 5-10 parts of casein peptide, 10-15 parts of a forming agent, 1-3 parts of an auxiliary forming agent and 1-3 parts of a disintegrating agent.
The sustained-release pellet is provided with a second pellet core, a second hydrophilic coating and a second hydrophobic coating from inside to outside, wherein the second pellet core comprises the following raw materials in parts by weight: 3-5 parts of gamma-aminobutyric acid, 3-5 parts of theanine, 5-8 parts of casein peptide, 5-10 parts of fish collagen peptide, 5-10 parts of orange peel enzyme liposome, 5-10 parts of spina date seed powder, 5-10 parts of poria cocos powder, 15-20 parts of a forming agent, 2-5 parts of an auxiliary forming agent and 2-5 parts of a disintegrating agent.
The quick-release pellet needs to quickly release the effective components after entering a human body, so the weight gain of the first hydrophobic coating is 0.05-0.2 percent based on the weight of the first pellet core; the effective components are released after the sustained-release pellet enters a human body for at least half an hour, and meanwhile, in order to ensure that the sleep-aiding effect does not continue to act every other day, the weight of the second hydrophobic coating is 0.5-1.5 percent based on the weight of the second pellet core, so that the effective components are completely released within 2 hours.
The first hydrophobic coating and the second hydrophobic coating are one or more of Ewing RL100, Ewing RL30D, Ewing RS100 and Ewing RS 30D.
The first hydrophilic coating and the second hydrophilic coating are both hydroxypropyl methylcellulose; the forming agent is one or more of pregelatinized starch, microcrystalline cellulose and powdered sugar; the auxiliary forming agent is one or more of mannitol, lactose, trehalose, glucose, starch, sorbitol and dextrin; the disintegrating agent is one or more of low-substituted hydroxypropyl cellulose, corn starch, crospovidone and sodium carboxymethyl starch.
The orange peel ferment liposome comprises the following raw materials in parts by weight: 80-150 parts of orange peel enzyme powder, 25-35 parts of phospholipid, 4-8 parts of trehalose, 1-3 parts of stigmasterol and 1-3 parts of polyethylene glycol. In order to reduce the damage of the freeze-drying process to the liposome structure as much as possible, the trehalose is added in the invention.
The preparation method of the tangerine peel ferment liposome comprises the following steps:
(1) weighing the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol according to a certain proportion, adding the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol into absolute ethyl alcohol, stirring until the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol are completely dissolved, and performing vacuum rotary evaporation until the absolute ethyl alcohol is completely evaporated, so that a lipid envelope is formed on the wall of a container;
(2) weighing the orange peel enzyme powder according to a ratio, slowly adding purified water until the orange peel enzyme powder is just dissolved to prepare orange peel enzyme liquid, pouring the orange peel enzyme liquid into the container in the step (1), setting a proper temperature and a proper rotating speed, and carrying out normal-pressure rotary hydration to form liposome suspension;
(3) and (3) uniformly emulsifying or ultrasonically treating the liposome suspension, stirring until the system is uniform, filtering for sterilization, and finally removing the solvent through a freeze-drying process to obtain the orange peel ferment liposome.
The preparation method of the sleep-aiding and beauty-maintaining solid beverage comprises the following steps:
(1) preparing a first pellet core: weighing the raw materials according to a certain proportion, adding the raw materials into a stirrer, fully stirring and uniformly mixing, pouring a proper amount of purified water, continuously stirring to prepare a soft material, transferring the soft material into an extrusion rounding machine, setting a proper speed and a proper duration for rounding and forming, and finally collecting and drying pill cores to obtain the first pill core;
(2) preparing a second pill core: weighing all the raw materials corresponding to the second pill core in proportion, and the rest steps are the same as the step (1);
(3) coating a first hydrophilic coating: weighing a proper amount of the first pellet core in a fluidized bed, setting proper air inlet temperature, spray gun atomization pressure and air inflow, spraying the raw material slurry of the first hydrophilic coating on the surface of the first pellet core at a slurry spraying rate of 0.5-1g/min until the surface of the first pellet core is completely coated, stopping slurry spraying, and directly drying in the fluidized bed in an air supply manner;
(4) the step of coating the second hydrophilic coating on the second pill core is the same as the step (3);
(5) coating a first hydrophobic coating, weighing a proper amount of the finished product in the step (3) in another fluidized bed, setting a proper air inlet temperature, a proper spray gun atomization pressure and a proper air inlet amount, spraying the raw material slurry of the first hydrophobic coating to the surface of the finished product in the step (3) at a slurry spraying speed of 0.5-1g/min until the surface of the finished product in the step (3) is coated with the first hydrophobic coating with a preset specific gravity, stopping slurry spraying, and directly drying in the fluidized bed in an air supply manner to obtain the quick-release pellets;
(6) step (4), coating the finished product with a second hydrophobic coating, and preparing the sustained-release pellet in the same step as the step (5);
(7) preparing the quick-release pellets and the sustained-release pellets according to the proportion of 1:2-4, and packaging to obtain the sleep-aiding and beauty-maintaining solid beverage.
The first hydrophilic coating, the second hydrophilic coating, the first hydrophobic coating and the second hydrophobic coating comprise a plasticizer, and the plasticizer is one or a mixture of more than one of triethyl citrate, polyethylene glycol, dibutyl sebacate, diethyl phthalate, tween-80 and propylene glycol.
The first hydrophilic coating, the second hydrophilic coating, the first hydrophobic coating and the second hydrophobic coating contain a lubricant, and the lubricant is one or more of stearic acid, glyceryl monostearate, talcum powder, calcium stearate, magnesium stearate and sodium stearyl fumarate.
The first hydrophilic coating, the second hydrophilic coating, the first hydrophobic coating and the second hydrophobic coating comprise an antifoaming agent, and the antifoaming agent is simethicone.
The quick-release pellets and the slow-release pellets can be added with different coloring agents for distinguishing.
The invention has the beneficial effects that:
(1) the invention adopts a mode of combining the quick-release pellets and the slow-release pellets, the quick-release pellets are quickly disintegrated after entering a human body, the effective components are released, the sleep-aiding effect is quickly exerted, the effective components are completely released after the slow-release pellets enter the human body for a period of time, and the action time of the sleep-aiding components is effectively prolonged; in addition, the quick-release pellets only contain a sleep-aiding component, so that the quick-release pellets are coated with a sufficient amount of the sleep-aiding component to realize the quick sleep-aiding function, and other components with the effects of tranquilizing and allaying excitement, maintaining beauty and keeping young are added into the slow-release pellets besides the sleep-aiding component;
(2) the invention can be taken together by drinking water, has no problem of residual sweetness of teeth, has extremely small volume and is easy to swallow, and consumers can mix the product into food which is used to eat before sleep, such as milk, honey water, a small cup of red wine and the like;
(3) the preparation process has strong operability and high production efficiency.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A solid beverage for improving sleep and caring skin comprises quick-release pellet and sustained-release pellet, wherein the ratio of the quick-release pellet to the sustained-release pellet is 1:3, and the outer diameters of the quick-release pellet and the sustained-release pellet are 1 mm. The quick-release pellet and the sustained-release pellet are respectively provided with a pellet core, a hydrophilic coating and a hydrophobic coating from inside to outside.
The quick-release pellet is provided with a first pellet core, a first hydrophilic coating (hydroxypropyl methylcellulose) and a first hydrophobic coating (Ettch RL30D) from inside to outside, and the weight gain of the first hydrophobic coating is 0.8% of the weight of the first pellet core. The first pill core comprises the following raw materials in parts by weight: 8 parts of gamma-aminobutyric acid, 8 parts of theanine, 7 parts of casein peptide, 12 parts of a forming agent (microcrystalline cellulose), 2 parts of an auxiliary forming agent (trehalose) and 2 parts of a disintegrating agent (corn starch).
The sustained-release pellet is provided with a second pellet core, a second hydrophilic coating (hydroxypropyl methylcellulose) and a second hydrophobic coating (Ewing RL30D) from inside to outside, and the weight gain of the second hydrophobic coating is 1% of the weight of the second pellet core. The second pill core comprises the following raw materials in parts by weight: 4 parts of gamma-aminobutyric acid, 4 parts of theanine, 7 parts of casein peptide, 8 parts of fish collagen peptide, 8 parts of orange peel enzyme liposome, 8 parts of spina date seed powder, 8 parts of poria cocos powder, 17 parts of a forming agent (microcrystalline cellulose), 3 parts of an auxiliary forming agent (trehalose) and 3 parts of a disintegrating agent (corn starch).
The orange peel ferment liposome comprises the following raw materials in parts by weight: 115 parts of orange peel enzyme powder, 30 parts of phospholipid, 6 parts of trehalose, 2 parts of stigmasterol and 2 parts of polyethylene glycol.
The preparation method of the tangerine peel ferment liposome comprises the following steps:
(1) weighing the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol according to a certain proportion, adding the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol into absolute ethyl alcohol, stirring until the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol are completely dissolved, carrying out vacuum rotary evaporation until the absolute ethyl alcohol is completely evaporated, and forming a lipid envelope on the wall of a container;
(2) weighing the orange peel enzyme powder according to a proportion, slowly adding purified water until the orange peel enzyme powder is just dissolved to prepare orange peel enzyme liquid, pouring the orange peel enzyme liquid into the container in the step (1), and rotationally hydrating for 0.5-1 hour at the temperature of 35-40 ℃, the rotating speed of 60-90rpm and the normal pressure to form liposome suspension;
(3) and (3) ultrasonically treating the liposome suspension by adopting an ice bath probe, wherein the power is 400-500W, stirring until the system is uniform, filtering and sterilizing through a sterile microporous filter membrane, and finally removing the solvent through a freeze drying process to obtain the orange peel ferment liposome.
The preparation method of the sleep-aiding and beauty-maintaining solid beverage comprises the following steps:
(1) preparing a first pellet core: weighing the raw materials according to a certain proportion, adding the raw materials into a stirrer, fully stirring and uniformly mixing the raw materials, pouring a proper amount of purified water, continuously stirring the mixture to prepare a soft material, transferring the soft material into an extrusion rounding machine, preparing a fine strip-shaped material by passing through a screen with the aperture of 0.5mm at the speed of 30Hz, putting the material into a turntable, rounding the material at the speed of 15Hz for 10 to 15 minutes, regulating the material to reversely rotate, rounding the material for 5 to 10 minutes, positively rotating the material at the speed of 25Hz, rounding the material at a high speed for 30 minutes, starting a fan to decelerate, and finally drying the material in an oven at the temperature of 40 ℃ for 1 hour to obtain a first pill core;
(2) preparing a second pill core: weighing all the raw materials corresponding to the second pill core in proportion, and the rest steps are the same as the step (1);
(3) coating a first hydrophilic coating by adopting a bottom spraying technology: weighing a proper amount of the first pellet cores in a Glatt fluidized bed, spraying materials by adopting a bottom spraying method, setting the air inlet temperature to be 30-40 ℃, the spray gun atomization pressure to be 0.1-0.3MPa and the air inlet amount to be 50-120m3Spraying the raw material slurry of the first hydrophilic coating on the surface of the first pellet core at a spraying speed of 0.5-1g/min until the surface of the first pellet core is completely coated, stopping spraying the slurry, and directly drying in a Glatt fluidized bed in an air supply manner for 5-10 minutes;
(4) the step of coating the second hydrophilic coating on the second pill core is the same as the step (3);
(5) coating a first hydrophobic coating by adopting a tangential spray technology, weighing a proper amount of the finished product in the step (3) in another Glatt fluidized bed, setting the air inlet temperature to be 35-45 ℃, the spray gun atomization pressure to be 0.2-0.5MPa and the air inlet amount to be 60-150m3Spraying the raw material slurry of the first hydrophobic coating on the surface of the finished product in the step (3) at a spraying speed of 0.5-1g/min until the surface of the finished product in the step (3) is coated with the first hydrophobic coating with a preset specific gravity, stopping spraying, and directly drying in a Glatt fluidized bed for 10-15 minutes in an air blowing manner to obtain the quick-release pellet;
(6) step (4), coating the finished product with a second hydrophobic coating, and preparing the sustained-release pellet in the same step as the step (5);
(7) preparing the quick-release pellets and the sustained-release pellets according to the proportion of 1:3, and packaging to obtain the sleep-aiding and beauty-maintaining solid beverage.
The invention combines two spraying technologies of Glatt multifunctional fluidized bed to coat the coating, and utilizes the bottom spraying technology to coat the hydrophilic coating, and the bottom spraying technology has the advantages that: the probability that the pill core contacts the raw material pulp is the same, which is favorable for realizing the uniformity of the hydrophilic coating, and the distance between the spray gun and the pill core is shorter, which is favorable for forming compact hydrophilic coating, and is especially suitable for the coating of the hydrophilic coating; the method is characterized in that a tangential spraying technology is utilized to coat the hydrophobic coating layer, the spray liquid of the tangential spraying technology is added into a hopper through an atomizing nozzle arranged on the wall of the hopper, the spraying direction of the nozzle is consistent with the fluidized state direction of the material, the air flow speed does not need to be changed in key, the amount of the gas entering a material groove can be adjusted, the method is particularly suitable for coating the hydrophobic coating layer, the drying rate is kept at a lower level, and the adhesion among pellets can be effectively prevented; the invention combines two spraying technologies to ensure that the outside of the pill core has a high-quality coating film so as to ensure that the invention has ideal quick-release effect and slow-release effect.
The invention does not adopt the conventional top spraying technology because the spraying direction is opposite to the airflow direction, the coated raw material slurry is evaporated to a certain degree before contacting with the pill core, the uniformity of the formed film is inferior to that of the bottom spraying technology and the tangential spraying technology, and the ideal slow release effect cannot be realized.
Example 2
A solid beverage for improving sleep and caring skin comprises quick-release pellet and sustained-release pellet, wherein the ratio of the quick-release pellet to the sustained-release pellet is 1:4, and the outer diameters of the quick-release pellet and the sustained-release pellet are 1.5 mm. The quick-release pellet and the sustained-release pellet are respectively provided with a pellet core, a hydrophilic coating and a hydrophobic coating from inside to outside.
The quick-release pellet is provided with a first pellet core, a first hydrophilic coating (hydroxypropyl methylcellulose) and a first hydrophobic coating (Ettky RL100) from inside to outside, and the weight gain of the first hydrophobic coating is 0.2% of the weight of the first pellet core. The first pill core comprises the following raw materials in parts by weight: 10 parts of gamma-aminobutyric acid, 10 parts of theanine, 10 parts of casein peptide, 15 parts of a forming agent (pregelatinized starch), 3 parts of an auxiliary forming agent (mannitol) and 3 parts of a disintegrating agent (low-substituted hydroxypropyl cellulose).
The sustained-release pellet is provided with a second pellet core, a second hydrophilic coating (hydroxypropyl methylcellulose) and a second hydrophobic coating (Ewing RL100) from inside to outside, and the weight gain of the second hydrophobic coating is 1.5% of the weight of the second pellet core. The second pill core comprises the following raw materials in parts by weight: 5 parts of gamma-aminobutyric acid, 5 parts of theanine, 8 parts of casein peptide, 10 parts of fish collagen peptide, 10 parts of orange peel enzyme liposome, 10 parts of spina date seed powder, 10 parts of poria cocos powder, 20 parts of a forming agent (pregelatinized starch), 5 parts of an auxiliary forming agent (mannitol) and 5 parts of a disintegrating agent (low-substituted hydroxypropyl cellulose).
The orange peel ferment liposome comprises the following raw materials in parts by weight: 150 parts of orange peel enzyme powder, 35 parts of phospholipid, 8 parts of trehalose, 3 parts of stigmasterol and 3 parts of polyethylene glycol.
The preparation method of the tangerine peel ferment liposome comprises the following steps:
(1) weighing the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol according to a certain proportion, adding the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol into absolute ethyl alcohol, stirring until the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol are completely dissolved, carrying out vacuum rotary evaporation until the absolute ethyl alcohol is completely evaporated, and forming a lipid envelope on the wall of a container;
(2) weighing the orange peel enzyme powder according to a proportion, slowly adding purified water until the orange peel enzyme powder is just dissolved to prepare orange peel enzyme liquid, pouring the orange peel enzyme liquid into the container in the step (1), and rotationally hydrating for 0.5-1 hour at the temperature of 35-40 ℃, the rotating speed of 60-90rpm and the normal pressure to form liposome suspension;
(3) and (3) ultrasonically treating the liposome suspension by adopting an ice bath probe, wherein the power is 400-500W, stirring until the system is uniform, filtering and sterilizing through a sterile microporous filter membrane, and finally removing the solvent through a freeze drying process to obtain the orange peel ferment liposome.
The preparation method of the sleep-aiding and beauty-maintaining solid beverage comprises the following steps:
(1) preparing a first pellet core: weighing the raw materials according to a certain proportion, adding the raw materials into a stirrer, fully stirring and uniformly mixing the raw materials, pouring a proper amount of purified water, continuously stirring the mixture to prepare a soft material, transferring the soft material into an extrusion rounding machine, preparing a fine strip-shaped material by passing through a screen with the aperture of 0.5mm at the speed of 30Hz, putting the material into a turntable, rounding the material at the speed of 15Hz for 10 to 15 minutes, regulating the material to reversely rotate, rounding the material for 5 to 10 minutes, positively rotating the material at the speed of 25Hz, rounding the material at a high speed for 30 minutes, starting a fan to decelerate, and finally drying the material in an oven at the temperature of 40 ℃ for 1 hour to obtain a first pill core;
(2) preparing a second pill core: weighing all the raw materials corresponding to the second pill core in proportion, and the rest steps are the same as the step (1);
(3) coating a first hydrophilic coating by adopting a bottom spraying technology: weighing appropriate amount of the first pellet core in a Glatt fluidized bed, setting air inlet temperature at 30-40 deg.C, spray gun atomization pressure at 0.1-0.3MPa and air inlet amount at 50-120m3Spraying the raw material slurry of the first hydrophilic coating on the surface of the first pellet core at a spraying speed of 0.5-1g/min until the surface of the first pellet core is completely coated, stopping spraying the slurry, and directly drying in a Glatt fluidized bed in an air supply manner for 5-10 minutes;
(4) the step of coating the second hydrophilic coating on the second pill core is the same as the step (3);
(5) coating a first hydrophobic coating by adopting a tangential spray technology, weighing a proper amount of the finished product in the step (3) in another Glatt fluidized bed, setting the air inlet temperature to be 35-45 ℃, the spray gun atomization pressure to be 0.2-0.5MPa and the air inlet amount to be 60-150m3Spraying the raw material slurry of the first hydrophobic coating on the surface of the finished product in the step (3) at a spraying speed of 0.5-1g/min until the surface of the finished product in the step (3) is coated with the first hydrophobic coating with a preset specific gravity, stopping spraying, and directly drying in a Glatt fluidized bed for 10-15 minutes in an air blowing manner to obtain the quick-release pellet;
(6) step (4), coating the finished product with a second hydrophobic coating, and preparing the sustained-release pellet in the same step as the step (5);
(7) preparing the quick-release pellets and the sustained-release pellets according to the proportion of 1:4, and packaging to prepare the sleep-aiding and beauty-maintaining solid beverage.
Example 3
A solid beverage for improving sleep and caring skin comprises quick-release pellet and sustained-release pellet, wherein the ratio of the quick-release pellet to the sustained-release pellet is 1:2, and the outer diameters of the quick-release pellet and the sustained-release pellet are 0.5 mm. The quick-release pellet and the sustained-release pellet are respectively provided with a pellet core, a hydrophilic coating and a hydrophobic coating from inside to outside.
The quick-release pellet is provided with a first pellet core, a first hydrophilic coating (hydroxypropyl methylcellulose) and a first hydrophobic coating (Ewing RS30D) from inside to outside, and the weight gain of the first hydrophobic coating is 0.05 according to the weight of the first pellet core. The first pill core comprises the following raw materials in parts by weight: 3 parts of gamma-aminobutyric acid, 3 parts of theanine, 5 parts of casein peptide, 10 parts of a forming agent (powdered sugar), 1 part of an auxiliary forming agent (sorbitol) and 1 part of a disintegrating agent (sodium carboxymethyl starch).
The sustained-release pellet is provided with a second pellet core, a second hydrophilic coating (hydroxypropyl methylcellulose) and a second hydrophobic coating (Ewing RS30D) from inside to outside, and the weight gain of the second hydrophobic coating is 0.5% of the weight of the second pellet core. The second pill core comprises the following raw materials in parts by weight: 3 parts of gamma-aminobutyric acid, 3 parts of theanine, 5 parts of casein peptide, 5 parts of fish collagen peptide, 5 parts of orange peel enzyme liposome, 5 parts of spina date seed powder, 5 parts of poria cocos powder, 15 parts of forming agent (powdered sugar), 2-5 parts of auxiliary forming agent (sorbitol) and 2 parts of disintegrating agent (sodium carboxymethyl starch).
The orange peel ferment liposome comprises the following raw materials in parts by weight: 80 parts of orange peel enzyme powder, 25 parts of phospholipid, 4 parts of trehalose, 1 part of stigmasterol and 1 part of polyethylene glycol.
The preparation method of the tangerine peel ferment liposome comprises the following steps:
(1) weighing the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol according to a certain proportion, adding the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol into absolute ethyl alcohol, stirring until the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol are completely dissolved, carrying out vacuum rotary evaporation until the absolute ethyl alcohol is completely evaporated, and forming a lipid envelope on the wall of a container;
(2) weighing the orange peel enzyme powder according to a proportion, slowly adding purified water until the orange peel enzyme powder is just dissolved to prepare orange peel enzyme liquid, pouring the orange peel enzyme liquid into the container in the step (1), and rotationally hydrating for 0.5-1 hour at the temperature of 35-40 ℃, the rotating speed of 60-90rpm and the normal pressure to form liposome suspension;
(3) and (3) ultrasonically treating the liposome suspension by adopting an ice bath probe, wherein the power is 400-500W, stirring until the system is uniform, filtering and sterilizing through a sterile microporous filter membrane, and finally removing the solvent through a freeze drying process to obtain the orange peel ferment liposome.
The preparation method of the sleep-aiding and beauty-maintaining solid beverage comprises the following steps:
(1) preparing a first pellet core: weighing the raw materials according to a certain proportion, adding the raw materials into a stirrer, fully stirring and uniformly mixing the raw materials, pouring a proper amount of purified water, continuously stirring the mixture to prepare a soft material, transferring the soft material into an extrusion rounding machine, preparing a fine strip-shaped material by passing through a screen with the aperture of 0.5mm at the speed of 30Hz, putting the material into a turntable, rounding the material at the speed of 15Hz for 10 to 15 minutes, regulating the material to reversely rotate, rounding the material for 5 to 10 minutes, positively rotating the material at the speed of 25Hz, rounding the material at a high speed for 30 minutes, starting a fan to decelerate, and finally drying the material in an oven at the temperature of 40 ℃ for 1 hour to obtain a first pill core;
(2) preparing a second pill core: weighing all the raw materials corresponding to the second pill core in proportion, and the rest steps are the same as the step (1);
(3) coating a first hydrophilic coating by adopting a bottom spraying technology: weighing appropriate amount of the first pellet core in a Glatt fluidized bed, setting air inlet temperature at 30-40 deg.C, spray gun atomization pressure at 0.1-0.3MPa and air inlet amount at 50-120m3Spraying the raw material slurry of the first hydrophilic coating on the surface of the first pellet core at a spraying speed of 0.5-1g/min until the surface of the first pellet core is completely coated, stopping spraying the slurry, and directly drying in a Glatt fluidized bed in an air supply manner for 5-10 minutes;
(4) the step of coating the second hydrophilic coating on the second pill core is the same as the step (3);
(5) coating a first hydrophobic coating by adopting a tangential spray technology, weighing a proper amount of the finished product in the step (3) in another Glatt fluidized bed, setting the air inlet temperature to be 35-45 ℃, the spray gun atomization pressure to be 0.2-0.5MPa and the air inlet amount to be 60-150m3Spraying the raw material slurry of the first hydrophobic coating on the surface of the finished product in the step (3) at a spraying speed of 0.5-1g/min until the surface of the finished product in the step (3) is pre-treatedCoating the first hydrophobic coating with a specific gravity, stopping spraying slurry, and directly drying in a Glatt fluidized bed for 10-15 minutes in an air blowing manner to obtain a quick-release pellet;
(6) step (4), coating the finished product with a second hydrophobic coating, and preparing the sustained-release pellet in the same step as the step (5);
(7) preparing the quick-release pellets and the sustained-release pellets according to the proportion of 1:2, and packaging to obtain the sleep-aiding and beauty-maintaining solid beverage.
And (3) measuring the release degree: the finished products of examples 1-3 were placed in a release medium (phosphate buffer), and the immediate release pellets of examples 1-3 all disintegrated completely within 10 minutes, while the sustained release pellets all did not change significantly within 0.5 hours and disintegrated completely after 2 hours.
The fast-release pellet is used as a fixed beverage, does not pursue the strict pharmacokinetic standard like a drug pellet, and only needs to be released as soon as possible after the fast-release pellet enters a human body and released after the slow-release pellet is released for at least half an hour.
Sleep-aiding and cosmetic efficacy tests:
(1) screening 90 volunteers, wherein the patients with insomnia lasts for more than one month after the age of 18-50 years;
(2) dividing the volunteers into 3 groups of test examples 1-3, each group comprising different age groups and sexes, wearing a sports bracelet for the volunteers to collect sleep data, and simultaneously detecting and recording the skin state of each volunteer;
(3) each volunteer was asked to take the test sample half an hour before sleep for 4 weeks.
(4) After 4 weeks, whether the sleep condition of the volunteer is improved or not is analyzed through the sleep data collected by the exercise bracelet, and meanwhile, the skin state of the volunteer is detected again to judge whether the skin state is improved or not.
The results show that the examples 1 to 3 have different degrees of sleep-aiding effect on 87 volunteers, the sleep-in time is short, the sleep quality of the volunteers is effectively improved, the emotion is obviously more stable and bright, and simultaneously, the skin states of all the volunteers are improved to a certain degree, such as the skin water-deficient state is improved, the glossiness is improved, the skin is firmed and the like.
Control experiment:
based on the component allocation ratio of example 3, the following 3 comparative examples were set:
comparative example 1: the gamma-aminobutyric acid and the theanine are lacked, and other components are consistent;
comparative example 2: the fish collagen and the tuckahoe powder are lacked, and other components are consistent;
comparative example 3: the orange peel enzyme and the wild jujube kernel powder are absent, and other components are consistent.
The volunteers taking the drug of example 3 were allowed to continue to participate in the control experiment, and the drug was taken in 3 groups, respectively, in control examples 1 to 3.
After completing the sleep-aiding and beauty-improving efficacy test for 3 days, the volunteers start to take the control cases respectively, after 4 weeks, the sleep condition of the volunteers is analyzed whether to be improved or not through the sleep data collected by the exercise bracelet, and meanwhile, the skin state of the volunteers is detected again to judge whether the skin state is improved or not.
The results show that:
(1) the volunteers of comparative example 1 took longer time to sleep than those of example 3, but the mood and skin were still improved equivalently, indicating that gamma-aminobutyric acid and theanine are the main effective sleep-aiding components of the present invention.
(2) Compared with the administration of the example 3, the volunteers taking the comparative example 2 have short sleep time, the sleep quality of the volunteers is effectively improved, the emotion is obviously more stable and bright, but the effect of improving the skin state is inferior to the administration of the example 3, which shows that the fish collagen and the tuckahoe powder are still required to be added for synergistic cooperation with other components if the optimal skin care effect is achieved.
(3) Compared with the administration of the example 3, the volunteers taking the comparative example 2 have short sleep time, but the sleep quality and emotion improvement effect after sleep is inferior to the administration of the example 3, and some volunteers are awakened after sleep, and the skin state is still equivalently improved, which shows that the orange peel enzyme, the spina date seed powder and other components are still required to be cooperatively matched if the optimal sleep-aiding effect is realized.
From the above control experiments, it can be seen that the present invention lacking some effective components still has some effects of improving sleep, soothing nerves and beautifying, but is inferior to example 3, therefore, the components of the present invention have synergistic effect.
Variations and modifications to the above-described embodiments may occur to those skilled in the art, which fall within the scope and spirit of the above description. Therefore, the present invention is not limited to the specific embodiments disclosed and described above, and some modifications and variations of the present invention should fall within the scope of the claims of the present invention. Furthermore, although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.
Claims (10)
1. The solid beverage is characterized by comprising quick-release pellets and slow-release pellets, wherein the quick-release pellets mainly comprise gamma-aminobutyric acid, theanine and casein peptide, and the slow-release pellets mainly comprise gamma-aminobutyric acid, theanine, casein peptide, fish collagen peptide, orange peel enzyme liposome, spina date seed powder and poria cocos powder.
2. The sleep-aiding and beauty-improving solid beverage according to claim 1, wherein the ratio of the quick-release pellets to the slow-release pellets is 1: 2-4.
3. The sleep-aiding and beauty-improving solid beverage according to claim 1, wherein the outer diameters of the quick-release pellets and the sustained-release pellets are 0.5 to 1.5 mm.
4. A sleep-aid and beauty solid beverage as claimed in any one of claims 1 to 3, wherein said quick-release pellets and said sustained-release pellets are provided with a pellet core, a hydrophilic coating and a hydrophobic coating from inside to outside.
5. The solid beverage for aiding sleep and beautifying face as claimed in claim 4, wherein the quick-release pellet is provided with a first pellet core, a first hydrophilic coating and a first hydrophobic coating from inside to outside, and the first pellet core comprises the following raw materials in parts by weight: 3-10 parts of gamma-aminobutyric acid, 3-10 parts of theanine, 5-10 parts of casein peptide, 10-15 parts of a forming agent, 1-3 parts of an auxiliary forming agent and 1-3 parts of a disintegrating agent;
the sustained-release pellet is provided with a second pellet core, a second hydrophilic coating and a second hydrophobic coating from inside to outside, wherein the second pellet core comprises the following raw materials in parts by weight: 3-5 parts of gamma-aminobutyric acid, 3-5 parts of theanine, 5-8 parts of casein peptide, 5-10 parts of fish collagen peptide, 5-10 parts of orange peel enzyme liposome, 5-10 parts of spina date seed powder, 5-10 parts of poria cocos powder, 15-20 parts of a forming agent, 2-5 parts of an auxiliary forming agent and 2-5 parts of a disintegrating agent.
6. The solid sleep-aid and beauty-aid beverage according to claim 5, wherein the weight gain of said first hydrophobic coating is 0.05-0.2% by weight of said first pellet core, the weight gain of said second hydrophobic coating is 0.5-1.5% by weight of said second pellet core, said first and second hydrophobic coatings are one or a mixture of more than one of Ewing RL100, Ewing RL30D, Ewing RS100, Ewing RS 30D.
7. The sleep-aiding and beauty-improving solid beverage according to claim 5, wherein the first hydrophilic coating and the second hydrophilic coating are both hypromellose; the forming agent is one or more of pregelatinized starch, microcrystalline cellulose and powdered sugar; the auxiliary forming agent is one or more of mannitol, lactose, trehalose, glucose, starch, sorbitol and dextrin; the disintegrating agent is one or more of low-substituted hydroxypropyl cellulose, corn starch, crospovidone and sodium carboxymethyl starch.
8. The solid beverage for aiding sleep and beautifying face as claimed in claim 1, wherein the tangerine peel ferment liposome comprises the following raw materials in parts by weight: 80-150 parts of orange peel enzyme powder, 25-35 parts of phospholipid, 4-8 parts of trehalose, 1-3 parts of stigmasterol and 1-3 parts of polyethylene glycol.
9. The solid beverage for sleep-aiding and beauty-improving according to claim 8, wherein the preparation method of the tangerine peel ferment liposome comprises the following steps:
(1) weighing the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol according to a certain proportion, adding the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol into absolute ethyl alcohol, stirring until the phospholipid, the trehalose, the stigmasterol and the polyethylene glycol are completely dissolved, and performing vacuum rotary evaporation until the absolute ethyl alcohol is completely evaporated, so that a lipid envelope is formed on the wall of a container;
(2) weighing the orange peel enzyme powder according to a ratio, slowly adding purified water until the orange peel enzyme powder is just dissolved to prepare orange peel enzyme liquid, pouring the orange peel enzyme liquid into the container in the step (1), setting a proper temperature and a proper rotating speed, and carrying out normal-pressure rotary hydration to form liposome suspension;
(3) and (3) uniformly emulsifying or ultrasonically treating the liposome suspension, stirring until the system is uniform, filtering for sterilization, and finally removing the solvent through a freeze-drying process to obtain the orange peel ferment liposome.
10. A method for preparing a sleep-aiding and beauty-improving solid beverage as claimed in any one of claims 1 to 9, comprising the steps of:
(1) preparing a first pellet core: weighing the raw materials according to a certain proportion, adding the raw materials into a stirrer, fully stirring and uniformly mixing, pouring a proper amount of purified water, continuously stirring to prepare a soft material, transferring the soft material into an extrusion rounding machine, setting a proper speed and a proper duration for rounding and forming, and finally collecting and drying pill cores to obtain the first pill core;
(2) preparing a second pill core: weighing all the raw materials corresponding to the second pill core in proportion, and the rest steps are the same as the step (1);
(3) coating a first hydrophilic coating: weighing a proper amount of the first pellet core in a fluidized bed, setting proper air inlet temperature, spray gun atomization pressure and air inflow, spraying the raw material slurry of the first hydrophilic coating on the surface of the first pellet core at a slurry spraying rate of 0.5-1g/min until the surface of the first pellet core is completely coated, stopping slurry spraying, and directly drying in the fluidized bed in an air supply manner;
(4) the step of coating the second hydrophilic coating on the second pill core is the same as the step (3);
(5) coating a first hydrophobic coating, weighing a proper amount of the finished product in the step (3) in another fluidized bed, setting a proper air inlet temperature, a proper spray gun atomization pressure and a proper air inlet amount, spraying the raw material slurry of the first hydrophobic coating to the surface of the finished product in the step (3) at a slurry spraying speed of 0.5-1g/min until the surface of the finished product in the step (3) is coated with the first hydrophobic coating with a preset specific gravity, stopping slurry spraying, and directly drying in the fluidized bed in an air supply manner to obtain the quick-release pellets;
(6) step (4), coating the finished product with a second hydrophobic coating, and preparing the sustained-release pellet in the same step as the step (5);
(7) preparing the quick-release pellets and the sustained-release pellets according to the proportion of 1:2-4, and packaging to obtain the sleep-aiding and beauty-maintaining solid beverage.
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Cited By (1)
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| CN118902084A (en) * | 2024-08-08 | 2024-11-08 | 天津华德益宝生命科学研发有限公司 | Marine special dietary food containing gamma-aminobutyric acid for maintaining beauty and keeping young |
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