CN113557236A - 一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 - Google Patents
一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 Download PDFInfo
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- CN113557236A CN113557236A CN202080018398.5A CN202080018398A CN113557236A CN 113557236 A CN113557236 A CN 113557236A CN 202080018398 A CN202080018398 A CN 202080018398A CN 113557236 A CN113557236 A CN 113557236A
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Abstract
一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物，所述调节剂具有如式I所示结构。双功能免疫调节剂包含同时阻断PD‑1/PD‑L1相互作用的苄苯醚类分子骨架和阻断TGF‑β信号通路的4‑(4‑吡唑)喹啉分子骨架，二者通过分子链片段相连接。因此，双功能免疫调节剂可同时阻断PD‑1/PD‑L1相互作用和TGF‑β信号通路。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019104979254 | 2019-06-10 | ||
| CN201910497925 | 2019-06-10 | ||
| PCT/CN2020/094580 WO2020248908A1 (zh) | 2019-06-10 | 2020-06-05 | 一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 |
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| Publication Number | Publication Date |
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| CN113557236A true CN113557236A (zh) | 2021-10-26 |
| CN113557236B CN113557236B (zh) | 2022-05-10 |
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| CN202080018398.5A Active CN113557236B (zh) | 2019-06-10 | 2020-06-05 | 一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 |
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| Country | Link |
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| US20100254899A1 (en) * | 2007-02-27 | 2010-10-07 | The United States Of America, As Represented By The Secretary, Dept Of Health And Human Services | Radiolabeled affibody molecules |
| CN105705489A (zh) * | 2013-09-04 | 2016-06-22 | 百时美施贵宝公司 | 用作免疫调节剂的化合物 |
| CN109305934A (zh) * | 2018-08-07 | 2019-02-05 | 成都海博锐药业有限公司 | 苯醚类衍生物及可药用盐、医药上的用途 |
| CN109824621A (zh) * | 2019-03-28 | 2019-05-31 | 中国药科大学 | 噁二唑类和噻二唑类化合物及其制备方法和用途 |
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| IL158512A0 (en) * | 2001-05-24 | 2004-05-12 | Lilly Co Eli | Novel pyrrole derivatives as pharmaceutical agents |
| UA80571C2 (en) * | 2002-11-22 | 2007-10-10 | Lilly Co Eli | Quinolinyl-pyrrolopyrazoles |
| US8871744B2 (en) * | 2010-07-21 | 2014-10-28 | B & G Partyers, LLC | Compounds and methods for selectively targeting tumor-associated mucins |
| US9850225B2 (en) * | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| CN116327915A (zh) * | 2015-04-03 | 2023-06-27 | 佐马技术有限公司 | 使用TGF-β抑制剂和PD-1抑制剂治疗癌症 |
| US10745382B2 (en) * | 2015-10-15 | 2020-08-18 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
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| CN1337950A (zh) * | 1999-01-08 | 2002-02-27 | 日本烟草产业株式会社 | 2－氧代喹啉化合物及其药物用途 |
| US20100254899A1 (en) * | 2007-02-27 | 2010-10-07 | The United States Of America, As Represented By The Secretary, Dept Of Health And Human Services | Radiolabeled affibody molecules |
| CN105705489A (zh) * | 2013-09-04 | 2016-06-22 | 百时美施贵宝公司 | 用作免疫调节剂的化合物 |
| CN109305934A (zh) * | 2018-08-07 | 2019-02-05 | 成都海博锐药业有限公司 | 苯醚类衍生物及可药用盐、医药上的用途 |
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