CN113430677A - Functional surface layer non-woven fabric capable of reducing skin barrier damage and preparation method thereof - Google Patents
Functional surface layer non-woven fabric capable of reducing skin barrier damage and preparation method thereof Download PDFInfo
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- CN113430677A CN113430677A CN202110772645.7A CN202110772645A CN113430677A CN 113430677 A CN113430677 A CN 113430677A CN 202110772645 A CN202110772645 A CN 202110772645A CN 113430677 A CN113430677 A CN 113430677A
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- 238000000034 method Methods 0.000 claims abstract description 28
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims abstract description 24
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
- D01F8/06—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one polyolefin as constituent
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
- C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
- D01F8/16—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one other macromolecular compound obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds as constituent
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H3/00—Non-woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length
- D04H3/005—Synthetic yarns or filaments
- D04H3/007—Addition polymers
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H3/00—Non-woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length
- D04H3/08—Non-woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of strengthening or consolidating
- D04H3/14—Non-woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of strengthening or consolidating with bonds between thermoplastic yarns or filaments produced by welding
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
- D06M15/03—Polysaccharides or derivatives thereof
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- D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
- D06M2101/16—Synthetic fibres, other than mineral fibres
- D06M2101/18—Synthetic fibres consisting of macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- D06M2101/20—Polyalkenes, polymers or copolymers of compounds with alkenyl groups bonded to aromatic groups
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- D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
- D06M2101/16—Synthetic fibres, other than mineral fibres
- D06M2101/30—Synthetic polymers consisting of macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- D06M2101/32—Polyesters
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- Absorbent Articles And Supports Therefor (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Abstract
The invention provides a functional surface layer non-woven fabric capable of reducing skin barrier damage, which is prepared according to the following steps: (1) modifying pectin with acrylic acid to obtain modified pectin; (1) modifying pectin with acrylic acid to obtain modified pectin; (2) carrying out hydrophilic grafting modification on the modified pectin and a polymer to obtain a modified hydrophilic substance; and (3) mixing the modified hydrophilic substance with the polymer to form the functional surface layer non-woven fabric. The invention also provides a method for preparing the functional surface layer non-woven fabric. Compared with the common non-woven fabric, the functional surface layer non-woven fabric can obviously reduce the generation of a 3D skin model inflammatory factor IL-1 alpha and obviously increase the generation of zonulin ZO-1, so that the functional surface layer non-woven fabric can be used for a surface layer of an incontinence product and helps to better maintain the skin barrier.
Description
Technical Field
The invention relates to the field of medical and sanitary textiles, in particular to a functional surface layer non-woven fabric capable of reducing damage to skin barriers caused by urine and excrement and a preparation method thereof. The functional facing nonwoven may be used in the manufacture of, for example, diapers, baby diapers, sanitary napkins, and pantiliners.
Background
With the increasing aging of the population and the improvement of the living standard of people, the application of the paper diaper is more and more common. However, the hot and humid environment inside the diaper, irritants in urine and feces, cause the pH inside the diaper to rise, enzymes inside the skin to be abnormally metabolized, the skin barrier to be damaged, and diaper rash to occur. Some diaper products on the market today have the option of adding some anti-inflammatory, anti-allergy, soothing skin care ingredients to reduce the occurrence of diaper rash (see patent applications CN108815556 and CN109512583A), but there is no indication that the relevant facing layer is beneficial for enhancing the skin barrier and reducing inflammation.
With the development of tissue engineering technology and the increasing importance of 3R (Reduction, Replacement and optimization) principles by people, the inventor is prompted to utilize a 3D skin model to replace animals for detection and evaluation, so that the inventor can simulate the influence of the use of diapers in actual life on the skin barrier through the 3D skin model, and simultaneously screen out a surface layer material with the optimal function on the protection of the skin barrier to reduce the occurrence of diaper rash.
Most literature suggests that IL-1 α is released when skin is damaged or irritated, and Garcia Bartels N, Massoudy L et al find that the diaper area produces more IL-1 α; meanwhile, the function of tight connection is closely related to the function of the permeable barrier of the skin, when the permeable barrier of the skin is damaged, external irritants can enter the skin more easily, and ZO-1 is a bridge forming a tight connection structure and is a marker molecule of the tight connection function. Therefore, according to the above two criteria, the inventors have unexpectedly obtained a top layer nonwoven fabric having a better skin barrier maintaining function.
Disclosure of Invention
In order to reduce the influence of the internal environment (such as moist and hot environment, irritants in urine and feces) of the paper diaper on the skin barrier, the inventor carries out graft modification on the modified pectin and the polypropylene fibers, so that the fibers have hydrophilicity and certain weak acidity simultaneously, and the modified pectin and the polypropylene fibers help to better maintain the acidity and alkalinity of the contact part with the skin, thereby protecting the skin barrier. The surface layer non-woven fabric with better skin barrier maintaining function can be used for the surface layers of disposable sanitary products, such as paper diapers, baby diapers, sanitary towels, sanitary underpants and the like, so as to reduce the situation that the skin barrier is damaged to cause diaper rash and the like.
Accordingly, in a first aspect, the present invention provides a functional facing nonwoven fabric capable of reducing skin barrier damage, the nonwoven fabric being prepared by the steps of:
(1) modifying pectin with acrylic acid to obtain modified pectin;
(2) carrying out hydrophilic grafting modification on the modified pectin and a polymer to obtain a modified hydrophilic substance; and
(3) and mixing the modified hydrophilic substance and the polymer according to a certain proportion to form the functional surface layer non-woven fabric.
Pectin is a natural polysaccharide extracted from fruits or vegetables and consists of two types, a homopolysaccharide and a heteropolysaccharide. They are mostly present in plant cell walls and cell inner layers, and are abundantly present in pericarp of citrus, lemon, grapefruit, etc. Is white to yellow powder, has relative molecular mass of about 20000-400000, and is tasteless. Is more stable in acidic solution than in alkaline solution. Pectin can help skin to recover pH value, and is a safe cosmetic material. According to the invention, the polymer is subjected to hydrophilic grafting by using the acrylic acid modified pectin, so that the hydrophilicity of the surface layer can be increased, the hydrophilic process in the post-treatment of the surface layer can be reduced, the acidity of the surface layer can be maintained, and the proper mixing ratio of the modified hydrophilic substance and the polymer is obtained after multiple trial runs in the step (3) of the preparation method, so that the pH of the non-woven fabric surface layer is basically maintained to be 4.55-5.10, and the irritation of the internal humid and hot environment, the pH of urine with higher pH and irritants such as protease in excrement in the actual use process of the paper diaper to the skin can be reduced.
According to a specific embodiment of the present invention, the modification of step (1) may comprise subjecting acrylic acid and pectin to an esterification reaction in the presence of a catalyst.
According to another specific embodiment of the present invention, the mass ratio of pectin to acrylic acid may be 1.5-2.5: 1.
According to a specific embodiment of the invention, the catalyst is concentrated sulfuric acid, and the addition amount thereof can be 0.5-1% of the mass of the reaction system.
According to another specific embodiment of the present invention, the reaction temperature of the step (1) may be 105-110 ℃ and the reaction time may be 1.5-2 hours.
According to a specific embodiment of the present invention, the hydrophilic graft modification of step (2) may comprise reacting the modified pectin with a polymer in the presence of an initiator. In the step (2), the polymer is subjected to hydrophilic grafting by using the acrylic acid modified pectin, so that the hydrophilicity of the surface layer can be increased, and the acidity of the surface layer can be maintained. The appropriate mixing ratio of the hydrophilic modification substance and the polymer is obtained after a plurality of trials in step (3) of the manufacturing method so that the pH of the nonwoven fabric facing is substantially maintained at 4.55 to 5.10.
According to a particular embodiment of the invention, the polymer may be polypropylene (PP), polyethylene/polypropylene fibres (PE/PP) or polyethylene/polyethylene terephthalate fibres (PE/PET).
According to another particular embodiment of the invention, the initiator may be benzoyl peroxide.
According to a specific embodiment of the invention, the addition amount of the initiator can be 1-2% of the mass of the reaction system, the addition amount of the modified pectin can be 30-40% of the mass of the reaction system, and the balance is the polymer.
According to another specific embodiment of the present invention, the reaction temperature of the step (2) may be 80 to 90 ℃, and the reaction time may be 6 to 7 hours.
According to a specific embodiment of the present invention, the step (3) may mix the modified hydrophilic substance with the polymer to form a non-woven fabric through a spunbond or through-air process.
According to a particular embodiment of the invention, the modified hydrophilic species may be added in an amount of 15 to 30%, preferably 18 to 28%, of the total mass of the mixture of modified hydrophilic species and the polymer.
According to a particular embodiment of the invention, the nonwoven fabric of the invention prepared according to the method may have a pH of 4.55 to 5.10, more preferably 4.80 to 4.90, most preferably 4.85. Too high a pH has little effect on the regulation of excreta and is detrimental to the health of the pH of the skin of the infant, i.e. loses the meaning of the present invention, while too low a pH may damage the otherwise fragile skin barrier of the infant, and therefore the present invention selects the above pH range.
The treated non-woven fabric according to the present invention is characterized in that the generation of the inflammatory factor IL-1 α can be significantly reduced and the expression of zonulin ZO-1 can be significantly increased, as compared to a general non-woven fabric.
In a second aspect, the present invention provides a method for preparing a functional facing nonwoven fabric capable of reducing skin barrier damage, comprising the steps of:
(1) modifying pectin with acrylic acid to obtain modified pectin;
(2) carrying out hydrophilic grafting modification on the modified pectin and a polymer to obtain a modified hydrophilic substance;
(3) and mixing the modified hydrophilic substance with the polymer to form the functional surface layer non-woven fabric.
According to a specific embodiment of the present invention, the modification of step (1) may comprise subjecting acrylic acid and pectin to an esterification reaction in the presence of a catalyst.
According to another specific embodiment of the present invention, the mass ratio of pectin to acrylic acid may be 1.5-2.5: 1.
According to a specific embodiment of the invention, the catalyst is concentrated sulfuric acid, and the addition amount thereof can be 0.5-1% of the mass of the reaction system.
According to another specific embodiment of the present invention, the reaction temperature of the step (1) may be 105-110 ℃ and the reaction time may be 1.5-2 hours.
According to a specific embodiment of the present invention, the hydrophilic graft modification of step (2) may comprise reacting the modified pectin with the polymer in the presence of an initiator. In the step (2), the polymer is subjected to hydrophilic grafting by using the acrylic acid modified pectin, so that the hydrophilicity of the surface layer can be increased, and the acidity of the surface layer can be maintained. The appropriate mixing ratio of the modified hydrophilic substance and the polymer is obtained after a plurality of trials in step (3) of the manufacturing method so that the pH of the nonwoven fabric face layer is substantially maintained at 4.55 to 5.10.
According to a particular embodiment of the invention, the polymer may be polypropylene (PP), polyethylene/polypropylene fibres (PE/PP) or polyethylene/polyethylene terephthalate fibres (PE/PET).
According to another particular embodiment of the invention, the initiator may be benzoyl peroxide.
According to a specific embodiment of the invention, the addition amount of the initiator can be 1-2% of the mass of the reaction system, the addition amount of the modified pectin can be 30-40% of the mass of the reaction system, and the balance is the polymer.
According to another specific embodiment of the present invention, the reaction temperature of the step (2) may be 80 to 90 ℃, and the reaction time may be 6 to 7 hours.
According to a specific embodiment of the present invention, the step (3) may mix the modified hydrophilic substance with the polymer to form a non-woven fabric through a spunbond or through-air process.
According to a particular embodiment of the invention, the modified hydrophilic species may be added in an amount of 15 to 30%, preferably 18 to 28%, of the total mass of the mixture of modified hydrophilic species and the polymer.
The invention has the beneficial effects that:
1. pectin is a natural polysaccharide extracted from fruits or vegetables, helps the skin to recover pH, and is a safe cosmetic material. The modified pectin is used for grafting the polymer, so that the hydrophilicity of the surface layer can be increased, the hydrophilic process in the post-treatment of the surface layer can be reduced, the acidity of the surface layer can be maintained, and the proper mixing ratio of the modified hydrophilic substance and the polymer is obtained after multiple machine tests in the step (3) of the preparation method, so that the pH of the non-woven fabric surface layer is basically maintained to be 4.55-5.10, and the irritation of the internal humid and hot environment, the pH of urine with high pH and irritants such as protease in excrement in the actual use process of the paper diaper to the skin can be reduced.
2. The functional surface layer non-woven fabric capable of reducing skin barrier damage can be screened by confirming the influence of the surface layer non-woven fabric on the skin barrier under the stimulation of artificial urine and protease by using a 3D skin model method, so that animal experiments are reduced.
Drawings
FIG. 1: influence of the coated nonwoven fabrics having pH values of 4.55(A1), 4.85(A2), 5.03(A3) and 5.22(A4) and the ordinary nonwoven fabric (A0) on the concentration of the inflammatory factor IL-1 alpha.
FIG. 2: influence of the nonwoven fabric A2(pH 4.85), A3(pH 5.03) and the plain nonwoven fabric (A0) as a comparison, which caused less inflammation after coating, and the nonwoven fabric A4(pH 5.22) on the optical density of the zon-1.
Detailed Description
In the following examples, pectin is obtained from hong Biotechnology Co., Ltd, polypropylene is obtained from Exxon Mobil chemical Co., Ltd, benzoyl peroxide is obtained from Qin Rui chemical Co., Ltd, concentrated sulfuric acid is obtained from Shengqing and chemical Co., Ltd, and polypropylene (PP) or polyethylene/polypropylene fiber (PE/PP) or polyethylene/polyethylene terephthalate fiber (PE/PET) is obtained from Jienzhi nonwoven Material Co., Ltd.
Example 1: preparation of functional nonwoven fabric capable of reducing skin barrier damage:
the first step is as follows: adding 1kg of acrylic acid, 1.5kg of pectin and 0.015kg of concentrated sulfuric acid serving as a catalyst into a reaction kettle for reaction at the reaction temperature of 105 ℃ for 2 hours to obtain modified pectin after the reaction is finished;
the second step is that: adding 5.4kg of polypropylene, 3.45kg of modified pectin and 0.13kg of benzoyl peroxide into a reaction kettle for hydrophilic grafting modification, wherein the reaction temperature is 80 ℃, and the reaction time is 6 hours, so as to finally obtain modified hydrophilic polypropylene;
the third step: after multiple machine tests, adding the obtained modified hydrophilic polypropylene into polypropylene (PP) to obtain a mixture, wherein the modified hydrophilic polypropylene accounts for 25% of the weight of the mixture, and preparing the mixture into a non-woven fabric by a spunbond method, wherein the pH value of the obtained non-woven fabric is 4.55.
Example 2:
the first step is as follows: adding 1kg of acrylic acid, 2kg of pectin and 0.018kg of concentrated sulfuric acid serving as a catalyst into a reaction kettle for reaction at the reaction temperature of 110 ℃ for 2 hours to obtain modified pectin after the reaction is finished;
the second step is that: adding 5.1kg of polyethylene/polypropylene fiber (PE/PP), 2.74kg of modified pectin and 0.1kg of benzoyl peroxide into a reaction kettle for hydrophilic grafting modification, wherein the reaction temperature is 90 ℃, and the reaction time is 6.5 hours, so as to finally obtain the modified hydrophilic PE/PP fiber;
the third step: after multiple trials, adding the obtained modified hydrophilic PE/PP fibers into PE/PP fibers to obtain a mixture, wherein the modified hydrophilic PE/PP fibers account for 20% of the mixture by weight, carding the mixture into a net at a high speed, forming a hot-air non-woven fabric by a hot-air preparation process of the non-woven fabric such as a hot-air oven, and the like, and the pH value of the obtained non-woven fabric is 4.85.
Example 3:
the first step is as follows: adding 1kg of acrylic acid, 1.5kg of pectin and 0.02kg of concentrated sulfuric acid serving as a catalyst into a reaction kettle for reaction at the reaction temperature of 105 ℃ for 2 hours to obtain modified pectin after the reaction is finished;
the second step is that: adding 5kg of polyethylene/polyethylene terephthalate (PE/PET) fiber, 2.44kg of modified pectin and 0.14kg of benzoyl peroxide into a reaction kettle for hydrophilic grafting modification, wherein the reaction temperature is 80 ℃, and the reaction time is 7 hours, so as to finally obtain the modified hydrophilic PE/PET fiber;
the third step: after multiple trials, adding the obtained modified hydrophilic PE/PET fibers into PE/PET fibers to obtain a mixture, wherein the modified hydrophilic PE/PET fibers account for 18% of the mixture by weight, carding the mixture into a net at a high speed, forming a hot-air non-woven fabric by a non-woven fabric hot-air process such as a hot-air oven, and the like, and the pH value of the obtained non-woven fabric is 5.03.
Example 4:
the first step is as follows: adding 1kg of acrylic acid, 1.5kg of pectin and 0.025kg of concentrated sulfuric acid serving as a catalyst into a reaction kettle for reaction at the reaction temperature of 105 ℃ for 1.5 hours to obtain modified pectin after the reaction is finished;
the second step is that: adding 6kg of polyethylene/polyethylene terephthalate (PE/PET) fiber, 2.64kg of modified pectin and 0.09kg of benzoyl peroxide into a reaction kettle for hydrophilic grafting modification, wherein the reaction temperature is 85 ℃, and the reaction time is 7 hours, so as to finally obtain the modified hydrophilic PE/PET fiber;
the third step: after multiple trials, adding the obtained modified hydrophilic PE/PET fibers into PE/PP fibers to obtain a mixture, wherein the modified hydrophilic PE/PET fibers account for 13% of the mixture by weight, carding the mixture into a net at a high speed, forming a hot-air non-woven fabric by a hot-air preparation process of the non-woven fabric such as a hot-air oven, and the like, and the pH value of the obtained non-woven fabric is 5.22.
Example 5:
the first step is as follows: adding 1kg of acrylic acid, 1.5kg of pectin and 0.02kg of concentrated sulfuric acid serving as a catalyst into a reaction kettle for reaction at the reaction temperature of 105 ℃ for 2 hours to obtain modified pectin after the reaction is finished;
the second step is that: adding 5kg of polyethylene/polyethylene terephthalate (PE/PET) fiber, 2.44kg of modified pectin and 0.14kg of benzoyl peroxide into a reaction kettle for hydrophilic grafting modification, wherein the reaction temperature is 80 ℃, and the reaction time is 7 hours, so as to finally obtain the modified hydrophilic PE/PET fiber;
the third step: after multiple trials, adding the obtained modified hydrophilic PE/PET fibers into PE/PET fibers to obtain a mixture, wherein the modified hydrophilic PE/PET fibers account for 28% of the mixture by weight, carding the mixture into a net at a high speed, forming a hot-air non-woven fabric by a non-woven fabric hot-air process such as a hot-air oven, and the like, and the pH value of the obtained non-woven fabric is 4.55.
Example 6:
the first step is as follows: adding 1kg of acrylic acid, 1.5kg of pectin and 0.02kg of concentrated sulfuric acid serving as a catalyst into a reaction kettle for reaction at the reaction temperature of 105 ℃ for 2 hours to obtain modified pectin after the reaction is finished;
the second step is that: adding 5kg of polyethylene/polyethylene terephthalate (PE/PET) fiber, 2.44kg of modified pectin and 0.14kg of benzoyl peroxide into a reaction kettle for hydrophilic grafting modification, wherein the reaction temperature is 80 ℃, and the reaction time is 7 hours, so as to finally obtain the modified hydrophilic PE/PET fiber;
the third step: after multiple trials, adding the obtained modified hydrophilic PE/PET fibers into PE/PET fibers to obtain a mixture, wherein the modified hydrophilic PE/PET fibers account for 22% of the mixture by weight, carding the mixture into a net at a high speed, forming a hot-air non-woven fabric by a non-woven fabric hot-air process such as a hot-air oven, and the like, and the pH value of the obtained non-woven fabric is 4.85.
Example 7:
the first step is as follows: adding 1kg of acrylic acid, 1.5kg of pectin and 0.02kg of concentrated sulfuric acid serving as a catalyst into a reaction kettle for reaction at the reaction temperature of 105 ℃ for 2 hours to obtain modified pectin after the reaction is finished;
the second step is that: adding 5kg of polyethylene/polyethylene terephthalate (PE/PET) fiber, 2.44kg of modified pectin and 0.14kg of benzoyl peroxide into a reaction kettle for hydrophilic grafting modification, wherein the reaction temperature is 80 ℃, and the reaction time is 7 hours, so as to finally obtain the modified hydrophilic PE/PET fiber;
the third step: after multiple trials, adding the obtained modified hydrophilic PE/PET fibers into PE/PET fibers to obtain a mixture, wherein the modified hydrophilic PE/PET fibers account for 14% of the mixture by weight, carding the mixture into a net at a high speed, forming a hot-air non-woven fabric by a non-woven fabric hot-air process such as a hot-air oven, and the like, and the pH value of the obtained non-woven fabric is 5.22.
Example 8: effect of functional surface layer non-woven fabrics with different pH values on concentration of inflammatory factor IL-1 alpha
This example verifies that the influence of functional surface layer non-woven fabrics that mix modified hydrophilic substance with different proportions and obtain different pH to producing inflammatory factor IL-1 alpha concentration, for reducing experimental error, the non-woven fabrics that following experimental result adopted all are the non-woven fabrics that adopt PE/PET fibre preparation.
The nonwoven fabrics prepared from the PE/PET fibers described in examples 3 and 5 to 7 and having pH values of 4.55(A1), 4.85(A2), 5.03(A3) and 5.22(A4) and the ordinary nonwoven fabric (A0) from Jiejizhi nonwoven materials Co., Ltd were cut, covered on a skin model, 15. mu.L of artificial urine containing protease was dropped, and the skin model was transferred to 37 ℃ with 5% CO2After incubation for 24 hours in an incubator with a relative humidity of 95%, the inflammatory factor IL-1. alpha. was collected, and 3 experiments were performed in parallel on each nonwoven fabric. The results of the experiment are shown in FIG. 1.
From figure 1 it can be seen that the blank model, the skin model stimulated directly with artificial urine containing protease, produced the most inflammatory factor IL-1 α. Compared with the common non-woven fabric, the non-woven fabric A1 (with the pH value of 4.55), A2 (with the pH value of 4.85) and A3 (with the pH value of 5.03) after treatment can reduce the generation of the inflammation factor IL-1 alpha, and the non-woven fabric A4 (with the pH value of 5.22) has almost no difference compared with the common non-woven fabric. The differential results compared to blank and a # compared to a 0.
Example 9: effect of functional surface layer non-woven fabrics with different pH values on optical density of zonulin ZO-1
This example demonstrates the effect of a functional facing nonwoven fabric with less inflammation after coating on the optical density of zonulin ZO-1.
Considering that the nonwoven fabric having a pH of 4.55 may cause some irritation to the skin without urine, and is not suitable for the production of products, the nonwoven fabric was not selected for the following test. Cutting non-woven fabrics A2(pH 4.85), A3(pH 5.03), common non-woven fabric (A0) and A4(pH 5.22) with good inflammation reducing effect, covering on skin model, dripping 15 μ L artificial urine containing protease, transferring the skin model to 37 deg.C, and adding 5% CO2The resulting nonwoven fabric was incubated in an incubator with a relative humidity of 95% for 24 hours, and the content of zonulin ZO-1 was expressed as an optical density, and 3 experiments were carried out in parallel for each nonwoven fabric. The results of the experiment are shown in FIG. 2.
The blank model is a skin model with only water added. From fig. 2, it can be seen that the zon-1 content of the conventional nonwoven fabric a0 is significantly reduced under the stimulation of artificial urine containing protease compared to the blank model, which indicates that it is presumed that the skin in the wrapped region may have a reduced zon-1 under the stimulation of urine and protease, whereas the ZO-1 content of the nonwoven fabric facing layer a2(pH 4.85) may be significantly increased compared to the conventional nonwoven fabric a0, while the ZO-1 content of the nonwoven fabric facing layer A3(pH 5.03) has no significant change compared to the conventional nonwoven fabric a0, and the ZO-1 content of the nonwoven fabric facing layer a4(pH 5.22) has no significant change compared to the conventional nonwoven fabric a 0. The differential results compared to the blank model and # compared to a 0.
In conclusion, the pectin-coated functional top sheet can reduce the generation of the inflammatory factor IL-1 alpha and increase the content of zon-1 under the stimulation of artificial urine and protease, and most preferably the pH value of the functional top sheet is 4.85, and it is presumed that the diaper using the functional top sheet can reduce the occurrence of diaper rash.
The present invention is described in more detail with reference to the following examples, which should not be construed as limiting the scope of the present invention. Modifications, variations and adaptations of the invention, which come within the scope of the invention, are intended to be covered by the following claims.
Claims (25)
1. A functional surface layer non-woven fabric capable of reducing skin barrier damage, which is prepared by the following steps:
(1) modifying pectin with acrylic acid to obtain modified pectin;
(2) carrying out hydrophilic grafting modification on the modified pectin and a polymer to obtain a modified hydrophilic substance; and
(3) and mixing the modified hydrophilic substance with the polymer to form the functional surface layer non-woven fabric.
2. The functional facing nonwoven fabric of claim 1, wherein said modification of step (1) comprises esterification of acrylic acid and pectin in the presence of a catalyst.
3. The functional surface layer nonwoven fabric according to claim 1, characterized in that the mass ratio of pectin to acrylic acid is 1.5-2.5: 1.
4. The functional surface non-woven fabric according to claim 2, wherein the catalyst is concentrated sulfuric acid, and the amount of the catalyst added is 0.5 to 1% by mass of the reaction system.
5. The functional surface layer nonwoven fabric according to claim 1, characterized in that the reaction temperature in the step (1) is 105-110 ℃ and the reaction time is 1.5-2 hours.
6. The functional topsheet nonwoven fabric of claim 1, wherein the hydrophilic graft modification of step (2) comprises reacting the modified pectin with the polymer in the presence of an initiator.
7. The functional topsheet nonwoven fabric of claim 6, wherein the polymer is polypropylene (PP), polyethylene/polypropylene fibers (PE/PP), or polyethylene/polyethylene terephthalate fibers (PE/PET).
8. The functional facing nonwoven fabric of claim 6, wherein said initiator is benzoyl peroxide.
9. The functional surface non-woven fabric according to claim 6, wherein the amount of the initiator added is 1 to 2% by mass of the reaction system, the amount of the modified pectin added is 30 to 40% by mass of the reaction system, and the balance is the polymer.
10. The functional topsheet nonwoven fabric according to claim 6, wherein the reaction temperature in the step (2) is 80 to 90 ℃ and the reaction time is 6 to 7 hours.
11. The functional facing nonwoven fabric of claim 1, wherein said step (3) is carried out by a spun-bond or hot-air process of said modified hydrophilic substance together with said polymer to obtain a nonwoven fabric.
12. The functional facing nonwoven according to claim 11, characterized in that the modified hydrophilic substance is added in an amount of 15-30%, preferably 18-28% of the total mass of the mixture of modified hydrophilic substance and the polymer.
13. The functional facing nonwoven fabric of any of claims 1-12, wherein the pH of the nonwoven fabric is from 4.55 to 5.10.
14. A method of making a functional facing nonwoven capable of reducing skin barrier damage comprising the steps of:
(1) modifying pectin with acrylic acid to obtain modified pectin;
(2) carrying out hydrophilic grafting modification on the modified pectin and a polymer to obtain a modified hydrophilic substance; and
(3) and mixing the modified hydrophilic modification substance with the polymer to form the functional surface layer non-woven fabric.
15. The method according to claim 14, wherein the modifying of step (1) comprises subjecting acrylic acid and pectin to an esterification reaction in the presence of a catalyst.
16. The method according to claim 14, characterized in that the mass ratio of pectin to acrylic acid is 1.5-2.5: 1.
17. The method according to claim 15, wherein the catalyst is concentrated sulfuric acid and is added in an amount of 0.5 to 1% by mass based on the mass of the reaction system.
18. The method as claimed in claim 14, wherein the reaction temperature in the step (1) is 105 ℃ to 110 ℃ and the reaction time is 1.5 to 2 hours.
19. The method according to claim 14, characterized in that the hydrophilic graft modification of step (2) comprises reacting the modified pectin with the polymer in the presence of an initiator.
20. The method according to claim 19, characterized in that the polymer is polypropylene (PP), polyethylene/polypropylene fibers (PE/PP) or polyethylene/polyethylene terephthalate fibers (PE/PET).
21. The method of claim 19, wherein the initiator is benzoyl peroxide.
22. The method according to claim 19, wherein the initiator is added in an amount of 1-2% by mass of the reaction system, the modified pectin is added in an amount of 30-40% by mass of the reaction system, and the balance is the polymer.
23. The method according to claim 19, wherein the reaction temperature of the step (2) is 80-90 ℃ and the reaction time is 6-7 hours.
24. The method according to claim 14, characterized in that the step (3) passes the modified hydrophilic substance together with the polymer through a hot air or spun bond process to obtain a nonwoven fabric.
25. Method according to claim 23, characterized in that the modified hydrophilic species is added in an amount of 15-30%, preferably 18-28% of the total mass of the mixture of modified hydrophilic species and the polymer.
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