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CN113425405A - Microwave ablation simulation temperature field correction method based on side-opening temperature measurement - Google Patents

Microwave ablation simulation temperature field correction method based on side-opening temperature measurement Download PDF

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CN113425405A
CN113425405A CN202110584531.XA CN202110584531A CN113425405A CN 113425405 A CN113425405 A CN 113425405A CN 202110584531 A CN202110584531 A CN 202110584531A CN 113425405 A CN113425405 A CN 113425405A
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冯宇
吴鑫
朱柔君
钱志余
俞钦栋
邹止寒
李梦雪
唐千舜
张丹
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Nanjing University of Aeronautics and Astronautics
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Abstract

本发明公开一种基于旁开测温的微波消融仿真温度场修正方法，以离体猪肝为例，步骤如下：根据猪肝大小，构建肝脏微波消融仿真模型；设置消融剂量即消融功率和消融时间以及探针位置（测温针及消融针插入深度、测温针距消融针旁开距离等），按预设消融剂量，完成仿真消融，获得预设旁开距离测温位点的温度变化数据；设计离体猪肝微波消融，将消融针与测温针按预设距位置并排插入猪肝中，开始实际消融，获得相同位点的实际温度数据；将实际温度数据与仿真温度数据进行对比，建立关系模型，进行仿真温度的修正；模型验证。本发明为精准化微波消融过程提供修正方案，对微波消融的术前仿真及仿真治疗具有重要参考价值。

Figure 202110584531

The invention discloses a microwave ablation simulation temperature field correction method based on side-open temperature measurement. Taking an isolated pig liver as an example, the steps are as follows: build a liver microwave ablation simulation model according to the size of the pig liver; set the ablation dose, that is, the ablation power and ablation Time and probe position (insertion depth of the temperature measuring needle and ablation needle, distance between the temperature measuring needle and the ablation needle, etc.), according to the preset ablation dose, complete the simulated ablation, and obtain the temperature change of the temperature measurement site at the preset side opening distance Data; microwave ablation of isolated pig liver is designed, the ablation needle and temperature measuring needle are inserted into the pig liver side by side according to the preset distance, and the actual ablation is started, and the actual temperature data of the same site is obtained; the actual temperature data and the simulated temperature data are analyzed. Contrast, establish a relational model, and modify the simulation temperature; model verification. The invention provides a correction scheme for precise microwave ablation process, and has important reference value for preoperative simulation and simulation treatment of microwave ablation.

Figure 202110584531

Description

Microwave ablation simulation temperature field correction method based on side-opening temperature measurement
Technical Field
The invention relates to the technical field of microwave ablation preoperative simulation, in particular to a microwave ablation simulation temperature field correction method based on side-by-side temperature measurement.
Background
The microwave thermal ablation therapy is considered to be a novel and effective method for treating malignant tumors after operations, chemotherapy, radiotherapy, immunotherapy and the like due to the advantages of obvious curative effect, minimal invasion, small toxic and side effects, few complications and the like, plays a great role in clinical tumor treatment, and is widely applied to more than 10 solid tumors such as liver cancer, lung cancer, kidney cancer, thyroid cancer and the like. However, there are still many scientific and technical problems to be solved in the microwave tumor thermal ablation, and one of the most important problems is preoperative temperature field simulation of the microwave ablation treatment effect.
The simulation result of the tissue microwave ablation temperature field is obtained under relatively ideal conditions. Ex vivo porcine liver has been considered as a "gold standard" sample for microwave ablation. There was also some discrepancy with the ex vivo porcine liver experimental results and simulations because of the difficulty in accurately mimicking the effects of tissue and blood perfusion. It is necessary to correct the simulated temperature field according to the actual temperature field.
At present, no microwave ablation simulation temperature field correction model based on side-opening temperature measurement exists.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a microwave ablation simulation temperature field correction method based on side-by-side temperature measurement, and an effective microwave ablation simulation temperature field correction model based on side-by-side temperature measurement is established by the method.
In order to achieve the purpose, the invention adopts the technical scheme that:
a microwave ablation simulation temperature field correction method based on bypass temperature measurement realizes correction of a microwave ablation simulation temperature field under the same condition according to the obtained actual temperature of a tissue in a microwave ablation process, and comprises the following steps:
s1, constructing a tissue microwave ablation simulation model according to the size of the tissue;
s2, setting ablation dosage, namely ablation power, ablation time and probe position, completing simulated ablation, and obtaining temperature change data of the preset bypass distance temperature measurement site;
s3, designing in vitro tissue microwave ablation, inserting an ablation needle and a temperature measuring needle into in vitro tissue side by side according to a preset distance position, starting actual microwave ablation, and obtaining actual temperature data of the same site;
s4, comparing multiple groups of actual temperature data of different sites under different ablation doses with simulation temperature data, establishing a relation model, and correcting the simulation temperature;
the specific steps of S4 include:
s401: outputting the simulated temperature value as S (t), wherein the experimentally measured temperature value is E (t), and t is the time point of data acquisition;
s402: curve fitting is carried out by taking S (t) as the horizontal axis x of the coordinate, and taking E (t) as the vertical axis y of the coordinate;
s403: obtaining:
y＝1.0284*x+2.43
i.e. the corrected temperature S1(t) is:
S1(t)＝1.0284*S(t)+2.43；
and S5, verifying the model.
Further, the temperature change simulation model in the microwave ablation simulation model in step S1 is implemented by using Comsol Multiphysics multi-physical field coupling software, which includes geometric design of the ablation needle and the tissue, setting of boundary conditions, setting of tissue dielectric property parameters, and setting of thermophysical property parameters.
Further, the ablation dosage in the step S2 is a combination of microwave ablation power and ablation duration; the probe position includes the depth of the microwave ablation needle inserted into the tissue and the coordinates of the thermometry site.
Further, the actual microwave ablation of the isolated tissue in the step S3 is realized by a microwave ablation and temperature acquisition system.
Further, the microwave ablation and temperature acquisition system comprises: the microwave ablation device comprises a microwave source 1, a microwave ablation needle 2, a temperature measuring needle 3, a temperature data collecting plate 5 and a PC6, wherein the microwave source 1 and the microwave ablation needle 2 are connected with each other, the temperature measuring needle 3, the temperature data collecting plate 5 and the PC6 are sequentially connected, and the microwave temperature measuring needle 2 and the temperature measuring needle 3 are inserted into an isolated tissue 4.
Preferably, the microwave source 1 is a 2450MHz microwave source, and the microwave ablation needle 2 is a Y-2450-B1 microwave ablation needle. The diameter of the temperature measuring needle 3 is 1.2mm, and the length is 180 mm; the microwave ablation needle 2 is a KY-2450-B1 microwave ablation needle, the diameter of the microwave ablation needle is 1.9mm, and the length of the microwave ablation needle is 150 mm.
Further, the microwave ablation needle 2 and the temperature measuring needle 3 are arranged in parallel in the in vitro tissue 4.
Further, the insertion depth of the microwave ablation needle 2 in actual microwave ablation and the position of the temperature measuring needle 3 are kept consistent with the simulation settings, wherein: the microwave ablation needle 2 and the temperature measuring needle 3 are inserted in the same plane; and performing microwave ablation according to the same power time to obtain temperature data of the whole ablation process.
Further, in step S4, the actual temperature data is compared with the simulated temperature data, and a relationship model between the two sets of data is established based on the actual temperature, so as to correct the simulated temperature.
Further, in the step S5, the model verification is to perform the in vitro tissue microwave ablation simulation and the actual ablation again under a certain same condition according to the established correction model, compare the simulation temperature data with the actual temperature data, and determine the model error.
Furthermore, in a plurality of groups of simulation ablation and actual ablation data acquisition experiments, the ablation power is selected from 50W, 60W and 70W, and the ablation time is respectively 3min, 5min, 7min and 10 min.
Furthermore, the temperature measuring needle and the microwave ablation needle are inserted into the tissue on the same plane, the microwave energy radiation point of the microwave ablation needle is 1cm away from the needle point, so that the microwave ablation needle is inserted into the tissue by 8cm, the temperature measuring needle is inserted into the tissue by 7cm, and the distance between the two needles is selected from 0.3cm, 0.5cm, 1.0cm and 1.5 cm; the ablation power, time and distance are matched arbitrarily.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention establishes a microwave ablation simulation temperature field correction model based on side-by-side temperature measurement effectively, and ensures that the microwave ablation simulation temperature field is more fit with the actual ablation temperature field.
2. The method has important significance for the visual simulation of the treatment effect before the microwave ablation operation, and can provide important reference for a doctor to determine a treatment plan.
Drawings
FIG. 1 is a schematic diagram of a microwave ablation and temperature acquisition system of the present invention;
FIG. 2 is a simulated temperature variation curve of different sites under 50W-5min ablation dosage in example 2 of the present invention;
FIG. 3 is the actual temperature variation curve of different sites under 50W-5min ablation dosage in example 2 of the present invention;
FIG. 4 is a modified model curve in example 2 of the present invention;
FIG. 5 is a comparison of the temperature field ablation zone after modification with the actual ablation zone in example 2 of the present invention; wherein (a) is the corrected simulated temperature field; (b) is the actual ablation zone.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
A microwave ablation simulation temperature field correction method based on bypass temperature measurement realizes correction of a microwave ablation simulation temperature field under the same condition according to the obtained actual temperature of a tissue in a microwave ablation process, and comprises the following steps:
s1, constructing a tissue microwave ablation simulation model according to the size of the tissue;
the temperature change simulation model in the microwave ablation simulation model in the step S1 is implemented by using Comsol Multiphysics multi-physical field coupling software, and includes geometric structure design of an ablation needle and a tissue, boundary condition setting, tissue dielectric property parameters and thermophysical property parameter setting;
s2, setting ablation dosage, namely ablation power, ablation time and probe position, completing simulated ablation, and obtaining temperature change data of the preset bypass distance temperature measurement site;
the ablation dosage in the step S2 is a combination of microwave ablation power and ablation duration; the probe position comprises the depth of the microwave ablation needle inserted into the tissue and the coordinates of the temperature measurement site;
s3, designing in vitro tissue microwave ablation, inserting an ablation needle and a temperature measuring needle into in vitro tissue side by side according to a preset distance position, starting actual microwave ablation, and obtaining actual temperature data of the same site;
the actual microwave ablation of the isolated tissue in the step S3 is realized through a microwave ablation and temperature acquisition system;
in particular, the microwave ablation and temperature acquisition system comprises: the microwave ablation device comprises a microwave source 1, a microwave ablation needle 2, a temperature measuring needle 3, a temperature data collecting plate 5 and a PC6, wherein the microwave source 1 and the microwave ablation needle 2 are connected with each other, the temperature measuring needle 3, the temperature data collecting plate 5 and the PC6 are sequentially connected, and the microwave temperature measuring needle 2 and the temperature measuring needle 3 are inserted into an isolated tissue 4.
Preferably, the microwave source 1 is a 2450MHz microwave source, and the microwave ablation needle 2 is a Y-2450-B1 microwave ablation needle. The diameter of the temperature measuring needle 3 is 1.2mm, and the length is 180 mm; the microwave ablation needle 2 is a KY-2450-B1 microwave ablation needle, the diameter of the microwave ablation needle is 1.9mm, and the length of the microwave ablation needle is 150 mm.
Preferably, the microwave ablation needle 2 and the temperature measuring needle 3 are arranged in parallel in the isolated tissue 4.
Specifically, the insertion depth of the microwave ablation needle 2 in the actual microwave ablation, the position of the thermometer needle 3 and the simulation settings are all kept consistent, wherein: the microwave ablation needle 2 and the temperature measuring needle 3 are inserted in the same plane; carrying out microwave ablation according to the same power time to obtain temperature data of the whole ablation process;
s4, comparing multiple groups of actual temperature data of different sites under different ablation doses with simulation temperature data, establishing a relation model, and correcting the simulation temperature;
in step S4, the actual temperature data is compared with the simulated temperature data, and a relationship model between the two sets of data is established with the actual temperature as a standard, so as to correct the simulated temperature.
The specific steps of step S4 include:
s401: outputting the simulated temperature value as S (t), wherein the experimentally measured temperature value is E (t), and t is the time point of data acquisition;
s402: curve fitting is carried out by taking S (t) as the horizontal axis x of the coordinate, and taking E (t) as the vertical axis y of the coordinate;
s403: obtaining:
y＝1.0284*x+2.43
i.e. the corrected temperature S1(t) is:
S1(t)＝1.0284*S(t)+2.43；
and S5, verifying the model.
Specifically, in step S5, the model verification is to perform the in vitro tissue microwave ablation simulation and the actual ablation again under a certain same condition according to the established correction model, compare the simulation temperature data and the actual temperature data, and determine the model error.
Furthermore, in a plurality of groups of simulation ablation and actual ablation data acquisition experiments, the ablation power is selected from 50W, 60W and 70W, and the ablation time is respectively 3min, 5min, 7min and 10 min.
Furthermore, the temperature measuring needle and the microwave ablation needle are inserted into the tissue on the same plane, the microwave energy radiation point of the microwave ablation needle is 1cm away from the needle point, so that the microwave ablation needle is inserted into the tissue by 8cm, the temperature measuring needle is inserted into the tissue by 7cm, and the distance between the two needles is selected from 0.3cm, 0.5cm, 1.0cm and 1.5 cm; the ablation power, time and distance are matched arbitrarily.
Example 2
A microwave ablation simulation temperature field correction method based on side-by-side temperature measurement takes pork liver as an example and comprises the following steps:
s1, constructing a liver microwave ablation simulation model according to the size of the pork liver;
s2, setting ablation dosage, namely ablation power, ablation time and probe position, completing simulated ablation, and obtaining temperature change data of the preset bypass distance temperature measurement site;
s3, designing in-vitro pig liver microwave ablation, inserting an ablation needle and a temperature measuring needle into a pig liver side by side according to a preset distance position, starting actual ablation, and obtaining actual temperature data of the same site;
s4, comparing multiple groups of actual temperature data of different sites under different ablation doses with simulation temperature data, establishing a relation model, and correcting the simulation temperature;
and S5, verifying the model.
As shown in fig. 1, the microwave ablation and temperature acquisition system comprises: the microwave ablation device comprises a microwave source 1, a microwave ablation needle 2, a temperature measuring needle 3, a temperature data acquisition board 5 and a PC6, wherein the microwave source 1 and the microwave ablation needle 2 are connected with each other, the temperature measuring needle 3, the temperature data acquisition board 5 and the PC6 are sequentially connected, and the microwave temperature measuring needle 2 and the temperature measuring needle 3 are inserted into an isolated tissue 4; the diameter of the temperature measuring needle 3 is 1.2mm, and the length is 180 mm; the microwave ablation needle 2 is a KY-2450-B1 microwave ablation needle, the diameter of the microwave ablation needle is 1.9mm, and the length of the microwave ablation needle is 150 mm; the microwave source 1 is a 2450MHz microwave source.
Before the experiment, the microwave ablation needle 2 is inserted into the liver by 8cm to ensure that the whole ablation area is in the liver parenchyma; inserting the temperature measuring needle 3 into the needle body for 7cm and placing the temperature measuring needle 3 and the microwave ablation needle 2 in parallel; in multiple data acquisition experiments, the ablation power was selected from 50W, 60W and 70W, and the ablation time was 3min, 5min, 7min and 10min, respectively. The distance between the two needles is selected from 0.3cm, 0.5cm, 1.0cm and 1.5 cm; the ablation power, time and distance are matched arbitrarily.
Fig. 2 is a simulated temperature variation curve of different sites under an ablation dosage of 50W-5min in the microwave ablation simulated temperature field correction method based on side-by-side temperature measurement provided by this embodiment.
Fig. 3 is an actual temperature change curve of different sites under an ablation dosage of 50W-5min in the microwave ablation simulation temperature field correction method based on side-by-side thermometry according to the embodiment of the present invention.
Fig. 4 is a corrected model curve of a microwave ablation simulation temperature field correction method based on side-by-side thermometry according to an embodiment of the present invention.
S401: outputting the simulated temperature value as S (t), wherein the experimentally measured temperature value is E (t), and t is the time point of data acquisition;
s402: curve fitting is carried out by taking S (t) as the horizontal axis (x) of the coordinate and E (t) as the vertical axis (y) of the coordinate;
s403: obtaining:
y＝1.0284*x+2.43
i.e. the corrected temperature S1t is:
S1(t)＝1.0284*S(t)+2.43
as shown in table 1, the relative error of the correction model constructed by the method for correcting the temperature field in microwave ablation simulation based on side-by-side temperature measurement is shown.
And performing isolated pig liver microwave ablation simulation and actual ablation under a certain same condition again according to the established correction model, comparing the simulation temperature data with the actual temperature data, and determining the model error.
TABLE 1 relative error between simulated temperature data and actual temperature data before and after correction
Figure BDA0003086635580000061
Fig. 5 is a comparison between the corrected temperature field ablation region and the actual ablation region of the microwave ablation simulation temperature field correction method based on side-by-side thermometry provided in this embodiment. Plot a is the simulated temperature field after correction and plot b is the actual ablation zone, with 55 ℃ as the critical temperature for cell death, also used as the threshold temperature for the simulated active zone.
As shown in table 2, the size error of the simulated ablation region and the actual ablation region before and after correction is compared, and as can be seen from table 2, the correction effect of the correction model is better, and the error between simulation and actual is greatly reduced, so that the simulation result is more fit with the actual ablation result.
TABLE 2 ablation zone size error
Error of relative error Short diameter Major diameter Short diameter: short diameter
Before correction 6.9％ 2.4％ 8.5％
After correction 0.7％ 2.3％ 1.7％
The invention discloses a microwave ablation simulation temperature field correction method based on side-by-side temperature measurement, which takes in-vitro pork liver as an example and comprises the following steps: constructing a liver microwave ablation simulation model according to the size of the pork liver; setting ablation dosage, namely ablation power, ablation time and probe positions (the insertion depth of a temperature measuring needle and the ablation needle, the side-opening distance between the temperature measuring needle and the ablation needle and the like), completing simulated ablation according to the preset ablation dosage, and obtaining temperature change data of a temperature measuring point with the preset side-opening distance; designing in-vitro pig liver microwave ablation, inserting an ablation needle and a temperature measuring needle into a pig liver side by side according to preset distance positions, starting actual ablation, and obtaining actual temperature data of the same site; comparing the actual temperature data with the simulation temperature data, establishing a relation model, and correcting the simulation temperature; and (5) verifying the model. The method provides a correction scheme for the precise microwave ablation process, and has important reference value for preoperative simulation and simulation treatment of microwave ablation.
The above description is only of the preferred embodiments of the present invention, and it should be noted that: it will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the principles of the invention and these are intended to be within the scope of the invention.

Claims (10)

1.一种基于旁开测温的微波消融仿真温度场修正方法，其特征在于：根据获得的组织在微波消融过程中的实际温度实现对同条件下微波消融仿真温度场的修正，包括以下步骤：1. a microwave ablation simulation temperature field correction method based on side opening temperature measurement, it is characterized in that: realize the correction of microwave ablation simulation temperature field under the same conditions according to the actual temperature of the tissue obtained in the microwave ablation process, comprising the following steps : S1、根据组织大小，构建组织微波消融仿真模型；S1. Build a tissue microwave ablation simulation model according to the size of the tissue; S2、设置消融剂量即消融功率和消融时间以及探针位置，完成仿真消融，获得预设旁开距离测温位点的温度变化数据；S2. Set the ablation dose, that is, the ablation power, the ablation time, and the probe position, complete the simulated ablation, and obtain the temperature change data of the temperature measurement site at the preset side-by-side distance; S3、设计离体组织微波消融，将消融针与测温针按预设距离位置并排插入离体组织中，开始实际微波消融，获得相同位点的实际温度数据；S3. Design the microwave ablation of the in vitro tissue, insert the ablation needle and the temperature measuring needle into the in vitro tissue side by side at a preset distance, start the actual microwave ablation, and obtain the actual temperature data of the same site; S4、将不同消融剂量下不同位点的多组实际温度数据与仿真温度数据进行对比，建立关系模型，进行仿真温度的修正；S4. Compare multiple sets of actual temperature data at different sites under different ablation doses with the simulated temperature data, establish a relationship model, and correct the simulated temperature; S4的具体步骤包括：The specific steps of S4 include: S401：将仿真出来的温度值输出为S(t)，实验测得的温度值为E(t)，t为数据采集的时间点；S401: Output the simulated temperature value as S(t), the experimentally measured temperature value as E(t), and t is the time point of data collection; S402：将S(t)作为坐标的横轴x，E(t)作为坐标的纵轴y进行曲线拟合；S402: Perform curve fitting with S(t) as the horizontal axis x of the coordinates and E(t) as the vertical axis y of the coordinates; S403：得到：S403: Got: y＝1.0284*x+2.43y=1.0284*x+2.43 即修正后的温度S1(t)为：That is, the corrected temperature S 1 (t) is: S1(t)＝1.0284*S(t)+2.43；S 1 (t)=1.0284*S(t)+2.43; S5、模型验证。S5, model validation. 2.根据权利要求1所述的基于旁开测温的微波消融仿真温度场修正方法，其特征在于，所述步骤S1中微波消融仿真模型中的温度变化仿真模型利用Comsol Multiphysics多物理场耦合软件实现，包括微波消融针和组织的几何结构设计、边界条件设定、组织介电特性参数和热物性参数设置。2. The microwave ablation simulation temperature field correction method based on side-open temperature measurement according to claim 1, wherein the temperature change simulation model in the microwave ablation simulation model in the step S1 utilizes Comsol Multiphysics multi-physics field coupling software The realization includes the geometric structure design of microwave ablation needle and tissue, the setting of boundary conditions, the setting of tissue dielectric properties and thermophysical parameters. 3.根据权利要求2所述的基于旁开测温的微波消融仿真温度场修正方法，其特征在于：所述步骤S2中消融剂量是微波消融功率和消融持续时间的组合；探针位置包括微波消融针插入组织的深度和测温位点的坐标。3. The microwave ablation simulation temperature field correction method based on side-open temperature measurement according to claim 2, characterized in that: in the step S2, the ablation dose is a combination of microwave ablation power and ablation duration; The depth of insertion of the ablation needle into the tissue and the coordinates of the temperature measurement site. 4.根据权利要求3所述的基于旁开测温的微波消融仿真温度场修正方法，其特征在于，所述步骤S3中离体组织实际微波消融通过微波消融与温度采集系统实现。4 . The microwave ablation simulation temperature field correction method based on side-open temperature measurement according to claim 3 , wherein the actual microwave ablation of the isolated tissue in the step S3 is realized by a microwave ablation and temperature acquisition system. 5 . 5.根据权利要求4所述的基于旁开测温的微波消融仿真温度场修正方法，其特征在于，所述微波消融与温度采集系统包括：微波源(1)、微波消融针(2)、测温针(3)、温度数据采集板(5)和PC(6)，所述微波源(1)和微波消融针(2)互相连接，所述测温针(3)、温度数据采集板(5)和PC(6)依次连接，所述微波测温针(2)和测温针(3)插入离体组织(4)。5 . The microwave ablation simulation temperature field correction method based on side opening temperature measurement according to claim 4 , wherein the microwave ablation and temperature acquisition system comprises: a microwave source (1), a microwave ablation needle (2), A temperature measuring needle (3), a temperature data collection board (5) and a PC (6), the microwave source (1) and the microwave ablation needle (2) are connected to each other, the temperature measuring needle (3), the temperature data collection board (5) is connected to the PC (6) in sequence, and the microwave temperature measuring needle (2) and the temperature measuring needle (3) are inserted into the isolated tissue (4). 6.根据权利要求5所述的基于旁开测温的微波消融仿真温度场修正方法，其特征在于，所述微波源(1)为2450MHZ微波源，所述微波消融针(2)为Y-2450-B1微波消融针。6. The microwave ablation simulation temperature field correction method based on side-open temperature measurement according to claim 5, wherein the microwave source (1) is a 2450MHZ microwave source, and the microwave ablation needle (2) is a Y- 2450-B1 Microwave Ablation Needle. 7.根据权利要求5所述的基于旁开测温的微波消融仿真温度场修正方法，其特征在于，所述微波消融针(2)与测温针(3)在离体组织(4)内平行设置。7. The microwave ablation simulation temperature field correction method based on side-open temperature measurement according to claim 5, wherein the microwave ablation needle (2) and the temperature measurement needle (3) are in the isolated tissue (4) Parallel setup. 8.根据权利要求5所述的基于旁开测温的微波消融仿真温度场修正方法，其特征在于，实际微波消融中微波消融针(2)的插入深度，测温针(3)所测位点都与仿真设置保持一致，其中：微波消融针(2)与测温针(3)保持同一平面插入；按照同样的功率时间进行微波消融，获得整个消融过程的温度数据。8. The microwave ablation simulation temperature field correction method based on side opening temperature measurement according to claim 5, characterized in that the insertion depth of the microwave ablation needle (2) in the actual microwave ablation, the position measured by the temperature measurement needle (3) All points are consistent with the simulation settings, in which: the microwave ablation needle (2) and the temperature measuring needle (3) are inserted in the same plane; microwave ablation is performed according to the same power and time, and the temperature data of the whole ablation process is obtained. 9.根据权利要求1所述的基于旁开测温的微波消融仿真温度场修正方法，其特征在于，所述步骤S4中，将实际温度数据与仿真温度数据进行对比，以实际温度为标准，建立两组数据之间的关系模型，对仿真温度进行修正。9. The microwave ablation simulation temperature field correction method based on side-open temperature measurement according to claim 1, wherein in the step S4, the actual temperature data is compared with the simulated temperature data, and the actual temperature is used as a standard, The relationship model between the two sets of data is established, and the simulation temperature is corrected. 10.根据权利要求1所述的基于旁开测温的微波消融仿真温度场修正方法，其特征在于，所述步骤S5中，模型验证是根据建立的修正模型重新进行某一同条件下的离体组织微波消融仿真与实际消融，对比仿真温度数据和实际温度数据，确定模型误差。10. The microwave ablation simulation temperature field correction method based on side-open temperature measurement according to claim 1, characterized in that, in the step S5, the model verification is to perform a new in vitro experiment under the same conditions according to the established correction model. Tissue microwave ablation simulation and actual ablation, compare the simulated temperature data with the actual temperature data, and determine the model error.
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