CN113320152A

CN113320152A - Quick-mounting type biological 3D printing collector

Info

Publication number: CN113320152A
Application number: CN202110744113.2A
Authority: CN
Inventors: 王金武; 王浩; 石国宏; 王赞; 刘同有; 黄信恒; 戴尅戎
Original assignee: Ninth Peoples Hospital Shanghai Jiaotong University School of Medicine; Shanghai Jiao Tong University
Current assignee: Ninth Peoples Hospital Shanghai Jiaotong University School of Medicine; Shanghai Jiao Tong University
Priority date: 2021-07-01
Filing date: 2021-07-01
Publication date: 2021-08-31

Abstract

A quick-installed 3D bioprinting collector provided by the present application includes: a base; a positioning clamping part, which is detachably fixed to one end of the base; and a rotating clamping part, which is detachably fixed on the base. The other end; a roller with a pattern, which is clamped between the positioning clamping part and the rotating clamping part, and drives the cylinder to rotate through the rotating clamping part, so that the cylinder can receive the sprayed water from the printer. Biospinning to obtain blood vessels with textured inner walls. The application adopts a modular assembly drum, and uses a positioning clamping part positioned by the tailstock and a rotating clamping part clamped by a chuck to fix the drum, which can realize the rapid replacement of the drum; the motor drives the drum to rotate to collect materials to form a tubular object, The printing of blood vessels is realized, and the roller is engraved with special lines, so that the inner wall of the printed blood vessels has special lines; there are magnets at the bottom of the bottom plate, which can realize rapid assembly with 3D printers.

Description

Quick-mounting type biological 3D printing collector

Technical Field

The application relates to the technical field of 3D printing collectors, in particular to a quick-mounting type biological 3D printing collector. Quick-assembling type biological 3D prints collector.

Background

The 3D printing technology can meet the medical requirements of individuation, small batch and large scale, is widely applied to the field of in vitro medical instrument manufacturing, is currently expanding towards the fields of individuation permanent implants, clinical repair treatment, drug research and development tests and the like, and can be dedicated to the direct printing of biological tissues and organs in the future.

In the aspect of manufacturing tubular artificial blood vessels, the small-caliber artificial blood vessels prepared by adopting an electrostatic spinning method have good application prospect, the electrostatic spinning technology is the prior art, an external high-voltage electric field is utilized to charge polymer solution, when the electric field intensity is strong enough, liquid drops at the tips of capillaries overcome surface tension to form jet flow, the polymer jet flow is stretched in the process of being emitted from the tips of capillary nozzles to a receiving end, and nano-scale fibers are formed after a solvent is volatilized. When the receiving end is a rotating roller, a tubular structure can be obtained.

This patent aims at collecting the silk that high pressure nozzle spun and pile up into the tubulose with the silk to the inner wall has special line, can simulate the relevant structure of blood vessel inner wall, has fine application prospect in the aspect of small-bore blood vessel preparation. And the cylinder can be changed fast to print the blood vessel that the inner wall has different lines. In addition, the high-voltage electric field spray head which is matched with the biological 3D printer is used on the biological 3D printer along with the movement of the X axis.

For example, patent 201620064830.5 discloses an electrostatic spinning collecting device, which is characterized by collecting uniform fiber layer in a reciprocating manner, patent 201810559364.1 discloses a method for preparing small-caliber artificial blood vessel based on electrostatic spinning,

however, these prior arts mainly aim at the field of electrostatic spinning, and are fixed by high-voltage ends, and the receiving device adopts a form of rotation combined with movement, and is not suitable for the existing biological 3D printer; in addition, the collecting device is large and is not easy to disassemble and assemble on corresponding facilities. The roller is not easy to disassemble and assemble. The operation is not good for the treatment after the collection is finished, and the inner wall of the generated small-caliber blood vessel is mostly smooth and is not in line with the characteristics of the actual blood vessel.

Disclosure of Invention

In view of the above shortcomings of the prior art, the present application aims to provide a quick-mounting type biological 3D printing collector to solve at least one existing problem in the problems of non-detachable roller, mostly smooth inner wall of blood vessel, non-adaption of the existing receiving device to the biological 3D printer, and the like in the existing biological 3D printing collector.

To achieve the above and other related objects, the present application provides a quick-mount bio 3D printing collector, comprising: a base; the positioning clamping part is detachably fixed at one end of the base; the rotary clamping part is detachably fixed at the other end of the base; and the roller is provided with the veins, is clamped between the positioning clamping part and the rotating clamping part and drives the roller to rotate through the rotating clamping part, so that the roller receives the biological spinning sprayed by the printer, and the blood vessel with the veins on the inner wall is obtained.

In an embodiment of the present application, the positioning and clamping portion includes: the tailstock support is arranged at one end of the base; a screw hole is arranged on the base for being detachably fixed on the base through a bolt; the tailstock is detachably inserted into a through hole formed in the tailstock support; one end of the roller for clamping is of a thimble structure so as to fix and position one end of the roller.

In an embodiment of the present application, the tailstock includes: the screw cylinder is inserted into a through hole in the tailstock support; the screw core is screwed in the screw cylinder and can move back and forth in the screw cylinder through rotation; the rocking handle is clamped or nested at the tail part of the screw rod core so as to drive the screw rod core to rotate by rocking the rocking handle, so that the screw rod core can move back and forth in the screw rod cylinder; the locking screw is arranged in a locking hole formed in the lead screw cylinder and used for locking the position of the lead screw core in the lead screw cylinder by screwing after the position of the lead screw core is adjusted; the chuck is sleeved at the head of the screw rod core; the clamping device comprises a bearing sleeve and a clamping opening, wherein the size of the clamping opening can be adjusted by rotating the bearing sleeve; the thimble is used for being placed at the clamping opening of the chuck and realizing screwing by screwing the bearing sleeve.

In an embodiment of the present application, the rotating clamping portion includes: the motor is detachably fixed at the other end of the base; the chuck is coupled with the motor and is driven by the motor to rotate; the front end of the chuck is provided with a plurality of chuck jaws with adjustable angles so as to clamp one end of the roller, and the roller rotates through a motor band.

In an embodiment of the present application, a fixing plate is disposed at the other end of the base; the motor is detachably fixed on one side of the fixing plate; the chuck is fixed to the other side of the fixing plate by being coupled to the motor.

In an embodiment of the present application, the fixing plate and the base are integrally formed; or, the fixing manner of the fixing plate and the base includes: any one of welding, nut, clamping groove, hinge joint and clamping.

In one embodiment of the present application, two ends of the roller are provided with protruding clamping shafts; the end part of the clamping shaft at one end is also provided with an ejector pin positioning hole for positioning and axially fixing the positioning and clamping part; different lines are engraved on the surface of the roller so that the inner wall of the blood vessel obtained after receiving the biological spinning sprayed by the printer is non-smooth.

In one embodiment of the present application, the drum includes: the surface of the roller sleeve is carved with different lines; the clamping main shaft is used for the roller sleeve to be sleeved in; and one end of the clamping main shaft is also provided with an ejector pin positioning hole for positioning and fixing the positioning and clamping part.

In an embodiment of the present application, the texture includes: any one of single texture, double texture, and cross texture.

In an embodiment of the present application, the base bottom is equipped with magnetism and inhales the device to supply to set up in the different positions of 3D printer at will.

To sum up, the application provides a biological 3D of fast-assembling type prints collector, includes: a base; the positioning clamping part is detachably fixed at one end of the base; the rotary clamping part is detachably fixed at the other end of the base; and the roller is provided with the veins, is clamped between the positioning clamping part and the rotating clamping part and drives the roller to rotate through the rotating clamping part, so that the roller receives the biological spinning sprayed by the printer, and the blood vessel with the veins on the inner wall is obtained.

Has the following beneficial effects:

the modular assembly roller is adopted, and the roller is fixed by the positioning clamping part positioned by the tailstock and the rotating clamping part clamped by the chuck, so that the roller can be quickly replaced; the motor drives the roller to rotate and collect the material to form a tubular object, so that the blood vessel is printed, and special grains are engraved on the roller, so that the inner wall of the blood vessel obtained by printing has special grains; there is magnet bottom the bottom plate, can realize with the rapid Assembly of 3D printer.

Drawings

Fig. 1 is a schematic structural diagram of a fast-assembling biological 3D printing collector according to an embodiment of the present disclosure.

Fig. 2 is a schematic structural view of a magnetic attraction device at the bottom of a base according to an embodiment of the present disclosure.

Fig. 3 is a schematic structural diagram of a positioning and clamping portion according to an embodiment of the present disclosure.

Fig. 4A is a schematic structural diagram of a roller according to an embodiment of the present disclosure.

Fig. 4B is a schematic structural diagram of a roller according to another embodiment of the present disclosure.

Detailed Description

The following description of the embodiments of the present application is provided by way of specific examples, and other advantages and effects of the present application will be readily apparent to those skilled in the art from the disclosure herein. The present application is capable of other and different embodiments and its several details are capable of modifications and/or changes in various respects, all without departing from the spirit of the present application. It is to be noted that the features in the following embodiments and examples may be combined with each other without conflict.

It should be noted that the drawings provided in the following embodiments are only schematic and illustrate the basic idea of the present application, and although the drawings only show the components related to the present application and are not drawn according to the number, shape and size of the components in actual implementation, the type, quantity and proportion of the components in actual implementation may be changed at will, and the layout of the components may be more complex.

Throughout the specification, when a part is referred to as being "connected" to another part, this includes not only a case of being "directly connected" but also a case of being "indirectly connected" with another element interposed therebetween. In addition, when a certain part is referred to as "including" a certain component, unless otherwise stated, other components are not excluded, but it means that other components may be included.

The terms first, second, third, etc. are used herein to describe various elements, components, regions, layers and/or sections, but are not limited thereto. These terms are only used to distinguish one element, component, region, layer or section from another element, component, region, layer or section. Thus, a first element, component, region, layer or section discussed below could be termed a second element, component, region, layer or section without departing from the scope of the present application.

Also, as used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context indicates otherwise. It will be further understood that the terms "comprises," "comprising," and/or "comprising," when used in this specification, specify the presence of stated features, operations, elements, components, items, species, and/or groups, but do not preclude the presence, or addition of one or more other features, operations, elements, components, items, species, and/or groups thereof. The terms "or" and/or "as used herein are to be construed as inclusive or meaning any one or any combination. Thus, "A, B or C" or "A, B and/or C" means "any of the following: a; b; c; a and B; a and C; b and C; A. b and C ". An exception to this definition will occur only when a combination of elements, functions or operations are inherently mutually exclusive in some way.

For solving the current biological 3D printing collector in the cylinder not detachable problem, the blood vessel inner wall is mostly smooth current situation, the current situation scheduling problem of the biological 3D printer of current receiving arrangement non-adaptation. The application provides a biological 3D of fast-assembling type prints collector.

Fig. 1 is a schematic structural diagram of a fast-assembling biological 3D printing collector in this embodiment. As shown, it includes: a base 1, a positioning clamping part 2, a rotating clamping part 3 and a roller 4 with a pattern.

A base 1; wherein, 1 bottom of base is equipped with magnetism and inhales device 11 to supply to set up at will in the different positions of 3D printer.

It should be noted that, a 3D printer usually has a specific printing structure or a specific printing space, and this has a certain size limitation for devices placed in a to-be-printed area of the 3D printer, and most of existing biological 3D printing collectors are large in size, and are not easy to disassemble and assemble, and cannot be well printed and fixedly connected with 3D. Therefore, 3D printers that are typically spun are often not adaptable.

The structure is retrencied to this application one side for this collector volume reduces, convenient and current biological 3D printer adaptation. In addition, as shown in fig. 2, a magnetic attraction device 11, such as a fixed 12-piece magnet, is further disposed at the bottom of the base 1, so that the collector and the 3D printer can be conveniently detached and fixed.

As shown in fig. 3, the positioning holder 2 is detachably fixed to one end of the base 1. Specifically, the positioning clamp 2 includes:

the tailstock bracket 21 is arranged at one end of the base 1; a screw hole 211 is arranged on the base for being detachably fixed on the base 1 through a bolt; in addition, the through hole 212 is arranged above the tailstock, and the area on the through hole 212 is separated, so that the size of the through hole 212 can be adjusted through a screw, namely, the clamping degree of the tailstock 22 can be adjusted through adjusting the size of the through hole 212.

The tailstock 22 is detachably inserted into a through hole 212 arranged on the tailstock support 21; one end of the roller 4 for clamping is of a thimble structure so as to fix and position one end of the roller. Specifically, the tailstock 22 includes:

a screw cylinder 221 for inserting into the through hole 212 of the tailstock support 21; a screw core 222 screwed into the screw cylinder 221 and movable forward and backward in the screw cylinder 221 by rotation; the rocking handle 223 is clamped or nested at the tail part of the screw rod core 222, so that the rocking handle 223 is shaken to drive the screw rod core 222 to rotate, and the screw rod cylinder 221 can move back and forth; a locking screw 224 disposed in a locking hole formed in the threaded cylinder 221, for locking the position of the threaded core 222 in the threaded cylinder 221 by screwing after the position of the threaded core 222 is adjusted; a collet 225 fitted around the head of the screw core 222; the clamping device comprises a bearing sleeve and a clamping opening, wherein the size of the clamping opening can be adjusted by rotating the bearing sleeve; and a thimble 226, which is used for being placed at the clamping opening of the clamping head 225 and is screwed by screwing the bearing sleeve.

In one or more embodiments, during the specific installation, the screw cylinder 221 and the matched screw core 222 are firstly inserted into the through hole 212 of the tailstock support 21, then the bearing sleeve is selectively screwed to open the clamping opening of the chuck 225 so as to put the thimble 226 in, then the bearing sleeve is reversely screwed to fasten the thimble 226, and then the extending length of the screw core 222 is adjusted by rotating the rocking handle 223 so as to adjust the proper position; finally, the locking screw 224 is tightened to fix the position of the lead screw core 222 in the lead screw cylinder 221.

In the present application, the thimble structure is mainly used to push one end of the roller 4 through one point of the thimble 226, so that when the other end drives the roller 4, the position of the central axis of the roller 4 will not change, and the rotation of the roller 4 will not be affected.

The rotary clamping part 3 is detachably fixed at the other end of the base 1 and is mainly used for driving the clamped roller 4 to rotate.

Specifically, the rotating clamp 3 includes: a motor 31 detachably fixed to the other end of the base 1; a chuck 32 coupled to the motor 31 for rotating the chuck 32 by the motor 31; the front end of the chuck 32 is provided with a plurality of chuck jaws 321 with adjustable angles, so as to clamp one end of the roller 4, and the roller 4 is driven to rotate by a motor 31.

In one embodiment of the present application, the other end of the base 1 is provided with a fixing plate 12. Wherein, the motor 31 is detachably fixed on one side of the fixing plate 12; the chuck 32 is fixed to the other side of the fixing plate 12 by being coupled to the motor 31.

It should be noted that the fixing plate 12 is not limited to be vertical as shown in fig. 1, and may be a horizontal fixing table or a side parallel to the axial direction of the clamping roller 4; of course, the number of the motor 31 and the chuck 32 is not limited to one, and may be two or more.

Correspondingly, the fixing modes of the motor 31 and the chuck 32 can be adjusted correspondingly, for example, the motor 31 and the chuck 32 can be on the same side, or can be fixed by different fixing plates 12, as long as the motor 31 is kept to drive the chuck 32 to rotate.

Preferably, the motor 31 can be fixed on the fixing plate 12 by bolts, and the fixing plate 12 has corresponding screw holes for installation.

In another embodiment of the present application, the fixing plate 12 and the base 1 are integrally formed; alternatively, the fixing means of the fixing plate 12 and the base 1 includes, but is not limited to: any one of welding, nut, clamping groove, hinge joint and clamping.

For example, the fixing plate 12 may be integrally formed at the time of factory shipment. Of course, in order to facilitate disassembly and assembly, the base 1 may be fixed in any common detachable or non-detachable manner.

Overall, the positioning and clamping part 2 and the rotating and clamping part 3 can position and fix the roller 4 as a main spinning receiver through matching, and drive the roller 4 to rotate when in use, and finally, the roller 4 can be quickly replaced.

The roller 4 with the veins is clamped between the positioning clamping part 2 and the rotating clamping part 3, and the rotating clamping part 3 drives the roller 4 to rotate, so that the roller 4 receives the biological spinning yarns sprayed by the printer, and the blood vessel with the veins on the inner wall is obtained.

As shown in fig. 4A, the two ends of the roller 4 are provided with protruding clamping shafts 42; wherein, the end of the clamping shaft 42 at one end is further provided with an ejector pin positioning hole 43 for positioning and axial fixing of the positioning and clamping part 2; the surface of the roller 4 is engraved with different lines 41 so that the inner wall of the blood vessel obtained after receiving the biological spinning sprayed by the printer is non-smooth.

For example, each roller 4 with the grain 41 is produced separately, and when the grain 41 needs to be replaced, the roller 4 is replaced directly.

Of course, in order to save manufacturing materials, the roller 4 may be designed in a way of changing the texture, which is as follows:

as shown in fig. 4B, the drum 4 includes: the roller sleeve 44, its surface is carved with different lines 41; a clamping main shaft 45 for the roller sleeve 44 to be sleeved in; one end of the clamping main shaft 45 is further provided with an ejector pin positioning hole 43 for positioning and fixing the positioning and clamping part 2.

In an embodiment of the present application, the texture 41 includes: any one of single texture, double texture, and cross texture. The lines are simple to manufacture, and the effect of obtaining the non-smooth blood vessels can be basically met.

For example, this application the installation of quick-assembling type biological 3D prints the collector and accomplishes the back, is connected with the printer, and 3D print head is located cylinder 4 top, is changeed cylinder 4 by motor 31 drive during the printing and rotates to the X axle of cooperation printer receives printer spun silk by cylinder 4, and then forms the tubulose, namely obtains the blood vessel that the inner wall has special pattern.

In summary, the device and the method solve the problem of quick replacement of the biological 3D printing blood vessel and the collecting roller, adopt the modularized component roller, adopt the tail seat positioned positioning clamping part and the chuck clamped rotating clamping part to fix the roller, and can realize quick replacement of the roller; the motor drives the roller to rotate and collect materials to form a tubular object, so that the blood vessel is printed, and special grains are engraved on the roller, so that the inner wall of the blood vessel obtained by printing has special grains; there is magnet bottom the bottom plate, can realize with the rapid Assembly of 3D printer.

The above embodiments are merely illustrative of the principles and utilities of the present application and are not intended to limit the application. Any person skilled in the art can modify or change the above-described embodiments without departing from the spirit and scope of the present application. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical concepts disclosed in the present application shall be covered by the claims of the present application.

Claims

1. The utility model provides a biological 3D of fast-assembling type prints collector which characterized in that includes:

a base;

the positioning clamping part is detachably fixed at one end of the base;

the rotary clamping part is detachably fixed at the other end of the base;

and the roller is provided with the veins, is clamped between the positioning clamping part and the rotating clamping part and drives the roller to rotate through the rotating clamping part, so that the roller receives the biological spinning sprayed by the printer, and the blood vessel with the veins on the inner wall is obtained.

2. The quick-to-mount biological 3D printing collector as claimed in claim 1, wherein the positioning clamp comprises:

the tailstock support is arranged at one end of the base; a screw hole is arranged on the base for being detachably fixed on the base through a bolt;

the tailstock is detachably inserted into a through hole formed in the tailstock support; one end of the roller for clamping is of a thimble structure so as to fix and position one end of the roller.

3. The quick-to-mount biological 3D printing collector as claimed in claim 2, wherein the tailstock comprises:

the screw cylinder is inserted into a through hole in the tailstock support;

the screw core is screwed in the screw cylinder and can move back and forth in the screw cylinder through rotation;

the rocking handle is clamped or nested at the tail part of the screw rod core so as to drive the screw rod core to rotate by rocking the rocking handle, so that the screw rod core can move back and forth in the screw rod cylinder;

the locking screw is arranged in a locking hole formed in the lead screw cylinder and used for locking the position of the lead screw core in the lead screw cylinder by screwing after the position of the lead screw core is adjusted;

the chuck is sleeved at the head of the screw rod core; the clamping device comprises a bearing sleeve and a clamping opening, wherein the size of the clamping opening can be adjusted by rotating the bearing sleeve;

the thimble is used for being placed at the clamping opening of the chuck and realizing screwing by screwing the bearing sleeve.

4. The quick-install biological 3D printing collector as claimed in claim 1, wherein the rotating clamp comprises:

the motor is detachably fixed at the other end of the base;

the chuck is coupled with the motor and is driven by the motor to rotate;

the front end of the chuck is provided with a plurality of chuck jaws with adjustable angles so as to clamp one end of the roller, and the roller rotates through a motor band.

5. The quick-to-mount biological 3D printing collector as claimed in claim 4, wherein a fixing plate is provided at the other end of the base; the motor is detachably fixed on one side of the fixing plate; the chuck is fixed to the other side of the fixing plate by being coupled to the motor.

6. The quick-to-mount biological 3D printing collector as claimed in claim 5, wherein the fixing plate is integrally formed with the base; or, the fixing manner of the fixing plate and the base includes: any one of welding, nut, clamping groove, hinge joint and clamping.

7. The quick-to-mount biological 3D printing collector as claimed in claim 1, wherein the two ends of the drum are provided with protruding clamping shafts; the end part of the clamping shaft at one end is also provided with an ejector pin positioning hole for positioning and axially fixing the positioning and clamping part; different lines are engraved on the surface of the roller so that the inner wall of the blood vessel obtained after receiving the biological spinning sprayed by the printer is non-smooth.

8. The quick-install biological 3D printing collector as claimed in claim 1, wherein the roller comprises:

the surface of the roller sleeve is carved with different lines;

the clamping main shaft is used for the roller sleeve to be sleeved in; and one end of the clamping main shaft is also provided with an ejector pin positioning hole for positioning and fixing the positioning and clamping part.

9. The quick-to-mount biological 3D printing collector as claimed in claim 7 or 8, wherein the texture comprises: any one of single texture, double texture, and cross texture.

10. The quick-to-mount biological 3D printing collector as claimed in claim 1, wherein the base is provided with a magnetic attraction device at the bottom thereof for being freely disposed at different positions of the 3D printer.