CN113304183A

CN113304183A - Application of elderberry in alcoholic bone remodeling, osteonecrosis and osteoporosis

Info

Publication number: CN113304183A
Application number: CN202110574926.1A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-05-26
Filing date: 2021-05-26
Publication date: 2021-08-27

Abstract

The invention discloses an application of elderberry in alcoholic bone reconstruction, osteonecrosis and osteoporosis, wherein the elderberry root bark contains a large amount of morroniside, which is a monomer with the maximum content in an effective part for promoting fracture healing, can promote the proliferation of cells, has no toxicity, can well inhibit apoptosis, and can change the descending goods rising of protein expression, thereby having better effect on treating the alcoholic bone reconstruction, the osteonecrosis and the osteoporosis, simultaneously the elderberry leaves are bitter, cool, activate blood, remove stasis and relieve pain, and is used for treating traumatic injury, rheumatism pain, bone and muscle pain, and the elderberry flowers are used for sweating, diuresis, the elderberry dispels wind, promotes diuresis, activates blood, relieves pain, and is used for treating rheumatism, bone and muscle pain, lumbago, edema, rubella, urticaria, postpartum anemic fainting, traumatic injury swelling and pain, fracture and wound hemorrhage, so the active ingredients of the elderberry are used for the alcoholic bone reconstruction, necrosis and osteoporosis, Has good effects on osteonecrosis and osteoporosis, and has no toxicity.

Description

Application of elderberry in alcoholic bone remodeling, osteonecrosis and osteoporosis

Technical Field

The invention relates to the technical field of application of elderberry, in particular to application of elderberry in alcoholic bone reconstruction, osteonecrosis and osteoporosis.

Background

Osteonecrosis is one of the common orthopedic disabling diseases, and the number of patients increases year by year. The carpal bone, the lunate bone, the tibial tubercle, the metatarsal bone, the scaphoid bone, the calcaneus bone, the mandible, the femur and the like all cause osteonecrosis, and the osteonecrosis of the femoral head is the most common cause in clinic. About 2000 million patients with femoral head necrosis exist in the world, wherein China accounts for about 25%, 15-30 million patients are newly increased every year, and about 80% of patients need artificial joint replacement due to femoral head collapse. Because of the wide clinical application of glucocorticoid in recent years, the glucocorticoid is a main cause of non-traumatic femoral head necrosis. Bone necrosis can be directly or indirectly induced by various factors such as trauma (femoral head fracture, femoral neck fracture, hip joint dislocation caused by hip injury, and hip soft tissue injury without fracture dislocation), alcohol, circulatory disturbance (femoral head necrosis caused by blood supply of adjacent joint surface tissue destroyed by rheumatism, hematopathy, diving disease, and burn). Without active treatment, most patients eventually require total hip replacement, which is expensive in treatment cost, more traumatic, and imposes a heavy economic burden on patients and society, and more serious, the life of the prosthesis has certain limitation, many patients may need to undergo multiple revision in one lifetime, and the life quality and labor capacity of the patients are seriously damaged, so that the disease is called as a 'catastrophic disease'. Therefore, a reliable treatment method capable of effectively preventing the collapse of the femoral head is urgently needed, and the important clinical significance and value of retaining the hip joint of a patient are achieved.

Osteoporosis is a systemic bone disease in which bone fracture is likely to occur due to decreased bone density and bone mass, destruction of bone microstructure, increased bone fragility, and increased bone fragility, which are caused by various causes (alcohol, hormone, diabetes, cushing's syndrome, hyperthyroidism, hyperparathyroidism, early menopause, hypogonadism, celiac disease, inflammatory bowel disease, liver cirrhosis, rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, anorexia nervosa, and the like). It is noted that, as the number of people who drink alcohol and the amount of alcohol consumption increase, the incidence rate of alcoholic osteoporosis is gradually increased, and the number of patients with hormonal osteoporosis also increases.

Alcoholic bone remodeling (also known as alcoholic bone remodeling, and alcoholic bone remodeling) is a common pathological process of alcoholic osteonecrosis, alcoholic osteoporosis, and the like. The alcoholic bone remodeling is the core of the pathological process of the alcoholic bone disease, can be used as a method for evaluating the influence of alcohol on bone homeostasis, bone metabolism, bone development, bone regeneration and the like, and is a core link for explaining the alcohol-induced bone disease and the bone dysfunction (in the aspects of structure, performance and the like).

The early research base shows that alcohol can induce oxidative stress disorder of organisms and cells, increase apoptosis of mesenchymal stem cells, and influence autophagy level and osteogenic differentiation. One of the most harmful effects of alcohol on cellular metabolism is associated with oxidative stress. Reactive oxygen radicals are continuously formed in aerobic organisms, and alcohol and its metabolites may intensify their growth. Oxidative stress is a negative effect produced in vivo by Reactive Oxygen Species (ROS) and is considered to be one of the important initiating factors leading to aging and bone damage. The role of ROS as a signaling, molecular regulatory, and transcriptional regulator has been gaining increasing attention in recent years. Mitochondria are important organelles in the redox balance of cells, are sites for generating ROS, and are highly vulnerable to ROS. Alcohol itself can activate CYP2E1 activity to cause ROS to rise, and can also mediate NADPH oxidase to generate Reactive Oxygen Species (ROS) to affect bones.

Disclosure of Invention

The technical problem to be solved by the invention is to overcome the technical defects and provide the application of the elderberry in alcoholic bone remodeling, osteonecrosis and osteoporosis, wherein the effective components of the elderberry have good effects on the alcoholic bone remodeling, osteonecrosis and osteoporosis and have no toxicity.

In order to solve the technical problems, the technical scheme provided by the invention is as follows: the ramulus Sambuci Williamsii is used in alcoholic bone reconstruction, osteonecrosis and osteoporosis.

The alcoholic bone remodeling is characterized by the abnormal bone mass and bone mass of the whole body, and is the comprehensive reflection of the abnormal metabolism of bone tissue cells induced by alcohol to cause the imbalance of bone homeostasis.

The alcoholic bone remodeling is manifested by bone marrow mesenchymal stem cells, osteoblasts, osteoclasts, osteocyte activity and dysfunction, which disrupts the osteoblast/osteoclast physiological balance.

The osteonecrosis is caused by long-term or excessive application of glucocorticoid and/or alcohol intake, and the like, and is common in clinic as femoral head necrosis.

Osteonecrosis is mainly characterized by microcirculation disturbance, lipid metabolism disorder and bone homeostasis imbalance in bone tissues.

The osteoporosis is primary osteoporosis and secondary osteoporosis, the primary osteoporosis is three types of postmenopausal osteoporosis, senile osteoporosis and idiopathic osteoporosis, and the secondary osteoporosis is osteoporosis caused by inducement such as alcohol, hormone, diabetes, cushing's syndrome, hyperthyroidism, hyperparathyroidism, early menopause, hypogonadism, celiac disease, inflammatory bowel disease, liver cirrhosis, rheumatoid arthritis, mandatory spondylitis, systemic lupus erythematosus and anorexia nervosa.

The postmenopausal osteoporosis generally occurs in 5-10 years after menopause of women, the senile osteoporosis generally refers to osteoporosis occurring after 70 years of age of the elderly, and the idiopathic osteoporosis mainly aims at teenagers.

The bonesetting leaves and the flowers of elderberry, the morroniside in the root bark of the elderberry and the pharmaceutically acceptable raw materials are prepared into pills, granules or medicinal powder.

Compared with the prior art, the invention has the advantages that: the elderberry root bark contains a large amount of morroniside, is a monomer with the largest content in an effective part for promoting fracture healing, can promote the proliferation of cells, has no toxicity, can well inhibit the apoptosis, and can change the reduction and rise of the expression of protein, so the elderberry root bark has better effect on treating alcoholic bone remodeling, osteonecrosis and osteoporosis, and simultaneously has bitter and cool elderberry leaves, blood circulation promotion, stasis removal and pain relief, is used for traumatic fracture, rheumatic arthralgia, bone and muscle pain, and elderberry flower is used for sweating, diuresis, and elderberry dispelling wind, dampness, blood circulation promotion and pain relief, and is used for rheumatic osteodynia, lumbago, edema, rubella, urticaria, postpartum anemic fainting, traumatic swelling and pain, fracture and traumatic bleeding, so the active ingredients of the elderberry have better effect on alcoholic bone remodeling, osteonecrosis and osteoporosis, and has no toxicity.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention discloses application of elderberry in alcoholic bone remodeling, osteonecrosis and osteoporosis.

Ramulus Sambuci Williamsii has effects of dispelling pathogenic wind, promoting diuresis, promoting blood circulation, and relieving pain. Can be used for treating rheumatism, osteodynia, lumbago, edema, rubella, urticaria, puerperal dizziness, traumatic injury, swelling and pain, fracture, and traumatic hemorrhage. Root or root bark (elderberry root): sweet and neutral. Can be used for treating rheumatic arthralgia, phlegm retention, edema, diarrhea, jaundice, traumatic injury, and scald. Leaf (elderberry leaf): bitter and cool. Promoting blood circulation, removing blood stasis, and relieving pain. Can be used for treating traumatic fracture, rheumatic arthralgia, and arthralgia and myalgia. Flower (elderberry flower): can be used for inducing perspiration and diuresis. The morroniside is a monomer with the largest content in the effective part of the elderberry root bark for promoting fracture healing, the content of the morroniside accounts for more than 50 percent of the effective part, the proliferation of MC3T3-E1 cells is promoted, and toxicity is avoided; in addition, MTT and flow type results show that morroniside can well inhibit apoptosis at more than 50 mu M, and the inhibition rate reaches 80%; the research of the mechanism shows that the morroniside can improve the reduction of Bcl-2 protein expression caused by TNF-alpha and reduce the increase of caspase3, caspase9, Bax, p-ERK, p-JNK and p-p38 protein expression caused by TNF-alpha. Morroniside belongs to iridoid compounds, has isomer alpha and beta configuration, molecular formula of C17H26O11, and relative molecular mass of 402.38. The source is wide, and the plants including dried mature pulp of fructus evodiae, mangnolia officinalis, taxus cuspidata and the like are one of the effective components of the six-position rehmannia pill. Has the functions of resisting oxidation, resisting apoptosis, resisting inflammation, promoting nerve cell growth, improving blood circulation and microvascular function and the like, so the medicine has good effect of treating alcoholic bone remodeling, osteonecrosis and osteoporosis.

The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. The ramulus Sambuci Williamsii is used in alcoholic bone reconstruction, osteonecrosis and osteoporosis.

2. Use of elder according to claim 1 in alcoholic bone remodeling, osteonecrosis and osteoporosis characterized by: the alcoholic bone remodeling is characterized by the abnormal bone mass and bone mass of the whole body, and is the comprehensive reflection of the abnormal metabolism of bone tissue cells induced by alcohol to cause the imbalance of bone homeostasis.

3. Use of elder according to claim 1 in alcoholic bone remodeling, osteonecrosis and osteoporosis characterized by: the alcoholic bone remodeling is manifested by bone marrow mesenchymal stem cells, osteoblasts, osteoclasts, osteocyte activity and dysfunction, which disrupts the osteoblast/osteoclast physiological balance.

4. Use of elder according to claim 1 in alcoholic bone remodeling, osteonecrosis and osteoporosis characterized by: the osteonecrosis is caused by long-term or excessive application of glucocorticoid and/or alcohol intake, and the like, and is common in clinic as femoral head necrosis.

5. Use of elder according to claim 1 in alcoholic bone remodeling, osteonecrosis and osteoporosis characterized by: osteonecrosis is mainly characterized by microcirculation disturbance, lipid metabolism disorder and bone homeostasis imbalance in bone tissues.

6. Use of elder according to claim 1 in alcoholic bone remodeling, osteonecrosis and osteoporosis characterized by: the osteoporosis is primary osteoporosis and secondary osteoporosis, the primary osteoporosis is three types of postmenopausal osteoporosis, senile osteoporosis and idiopathic osteoporosis, and the secondary osteoporosis is osteoporosis caused by inducement such as alcohol, hormone, diabetes, cushing's syndrome, hyperthyroidism, hyperparathyroidism, early menopause, hypogonadism, celiac disease, inflammatory bowel disease, liver cirrhosis, rheumatoid arthritis, mandatory spondylitis, systemic lupus erythematosus and anorexia nervosa.

7. Use of elder in alcoholic bone remodeling, osteonecrosis and osteoporosis according to claim 6, wherein: the postmenopausal osteoporosis generally occurs in 5-10 years after menopause of women, the senile osteoporosis generally refers to osteoporosis occurring after 70 years of age of the elderly, and the idiopathic osteoporosis mainly aims at teenagers.

8. Use of elder according to any one of claims 1 to 7 in alcoholic bone remodeling, osteonecrosis and osteoporosis characterized by: the bonesetting leaves and the flowers of elderberry, the morroniside in the root bark of the elderberry and the pharmaceutically acceptable raw materials are prepared into pills, granules or medicinal powder.