CN113289092B - Suction device and suction method synchronous with pulse - Google Patents

Abstract

The invention provides a pumping device and a pumping method synchronous with pulse, wherein the pumping device comprises a pumping pump, a pumping pipeline and a pulse detection device, the pulse detection device is electrically connected with a controller of the pumping pump, the pumping pump pumps through the pumping pipeline, the pumping pump provides pulse pressure, and the controller adjusts the pulse pressure according to a pulse signal detected by the pulse detection device so that the pulse starting time of the pulse pressure and the contraction pressure of the pulse are kept synchronous within a preset time error range. The invention can detect the pulse of the sucked object while sucking, synchronize the sucked pulse pressure with the contraction pressure of the pulse, and superimpose the adjustable pulse negative pressure synchronized with the human body vasoconstriction pressure on the set constant suction negative pressure so as to improve the suction efficiency and reduce the excessive blood loss flow velocity.

Description

Suction device and suction method synchronous with pulse

Technical Field

The invention relates to the field of medical equipment, in particular to pumping equipment and a pumping method synchronous with pulse.

Background

Thrombosis is a clinically common disease. The main harm of thrombus is 1) that the thrombus blocks the vascular cavity to block the blood backflow at the far end, and 2) that the thrombus falls off to cause serious harm such as pulmonary embolism, cerebral embolism, myocardial ridge plug and the like. Thrombus aspiration is a method in which a catheter is sent to a thrombus site under negative pressure to directly suck thrombus into the catheter and remove the thrombus. The advantage of catheter intervention methods for thrombus aspiration is (1) minimally invasive. The high-risk embolic patient is critical in illness, is difficult to endure the traditional open operation, relatively speaking, the interventional therapy completes the suction operation of the catheter under the local anesthesia, has small wound and quick recovery, and has quick effectiveness.

Current development of thrombus aspiration technology focuses on several aspects:

1. Suction catheter and Integrated System-suction catheter integrated System consists of a guide catheter or balloon catheter, delivery catheter and suction catheter, suction pump, plaque collector and plaque debris device (US 2019/0216476A1-Penumbar Inc.)

2. The aspiration catheter has two aspiration and irrigation channels, and the control box is linked to the two channels of the catheter to perform aspiration and irrigation under synchronous control (US 10944944B2-Boston SCIENTIFIC SCIMED INC; US9332999B2-Covidient LP), thereby preventing the aspiration channel from being plugged and requiring aspiration of the catheter to clear thrombotic plaque and reinsertion of the catheter.

3. A strain gauge or differential pressure sensor is placed on the aspiration catheter and the controller calculates the flow from the differential pressure to monitor whether the aspiration catheter tip is in contact with the clot. If there is no contact, the on-off valve in the suction connecting tube is automatically closed to stop suction. If the catheter is blocked, pulsed suction is activated (US 6022747-Bayer CO; US16/977431-Penumbar Inc).

The blood loss in the thrombus sucking process is related to the pressure difference at the two ends of the catheter, the pressure difference is large, the sucking force is large, and the risk of excessive blood loss is high. At present, no good control method is available for improving the thrombus sucking efficiency and reducing the blood loss. The thrombus aspiration efficiency is considered to be the time required to complete aspiration of the thrombus by overcoming the adhesion between the thrombus and the vessel wall at a certain aspiration pressure. Simulation calculations performed in the industry have indicated that for a thrombus of 5cm length, the aspiration of a 110cm aspiration catheter is completed for about 120 seconds at a suction negative pressure of-60 Kpa (about 450 mmHg) and for a thrombus of 3cm length, the aspiration of a 110cm aspiration catheter is completed for about 100 seconds at a suction negative pressure of-40 Kpa (about 300 mmHg) when the adhesion of the thrombus to the vessel wall is at 0.1N. If the adhesion force between the thrombus and the vessel wall is reduced to 0.001N, the suction is required to be completed within 100-140 seconds under the high suction negative pressure of-40 kPa to-60 KPa (about 300-450 mmHg) for a thrombus with a length of 5cm, and the suction is required to be completed within 80-90 seconds under the suction negative pressure of-30 kPa (about 225 mmHg) for a thrombus with a length of 3 cm. If a clinically acceptable negative suction pressure (-30 to-40 kPA) is selected, the low suction efficiency will result in increased blood loss, which will lead to decreased hemoglobin concentration.

Disclosure of Invention

In view of the drawbacks of the prior art, an object of the present invention is to provide a pumping device and a pumping method synchronized with the pulse.

The invention provides a pumping device synchronous with pulse, which comprises a pumping pump, a pumping pipeline and a pulse detection device;

The pulse detection device is electrically connected with a controller of the suction pump, and the suction pump sucks through the suction pipeline;

The suction pump provides a pulsed pressure;

the controller adjusts the pulse pressure according to the pulse signal detected by the pulse detection device, so that the pulse starting time of the pulse pressure and the contraction pressure of the pulse are kept synchronous within a preset time error range.

Preferably, the pulse pressure includes a baseline pressure P0, and a pulse with a pressure variation dP superimposed on the baseline pressure P0.

Preferably, the baseline pressure P0, the amount of pressure change of the pulse, and the duration T are adjustable.

Preferably, the baseline pressure P0 and the pressure variation dP are both negative pressures.

Preferably, the waveform of the pulse pressure includes a square wave, a triangular wave, or the same as the pulse signal.

Preferably, the pulse detection device comprises an electrocardiograph monitor, a blood pressure monitor, a pressure sensor, a flow rate sensor, a flow sensor or a micro-electromechanical system.

Preferably, a fluid flow rate sensor is arranged in the suction pipeline;

in the case that the flow rate is detected to be slow, judging that an object is sucked into the suction pipeline;

The flow rate of the suction fluid is calculated from the product of the flow rate and the cross-sectional area of the suction line.

Preferably, the fluid flow rate sensor includes a heater, a first temperature sensor, and a second temperature sensor;

A preset distance D is arranged between the first temperature sensor and the second temperature sensor, the heater is arranged at the first temperature sensor or at one side of the first temperature sensor far away from the second temperature sensor;

The heater heats the temperature of the fluid to be detected to enable the fluid to be detected to generate temperature pulses for the first temperature sensor and the second temperature sensor to detect, so that a time interval T between the first temperature sensor and the second temperature sensor for detecting the temperature pulses is obtained;

flow rate v=d/T of fluid.

According to the invention, the pulse synchronous pumping method comprises the pulse synchronous pumping equipment;

fixing a pulse detection device on a sucked object to acquire a pulse signal of the sucked object;

Setting a baseline pressure and a pulse variation of a pulse pressure sucked by a suction pump according to a sucked object;

the suction pump keeps the pulse starting time of the pulse pressure and the contraction pressure of the pulse synchronous within a preset time error range according to the pulse signal.

Preferably, the method is used for aspiration of thrombi;

a fluid flow rate sensor is arranged in the suction pipeline;

in the case that the flow rate is detected to be slow, judging that thrombus is sucked into the suction pipeline;

and calculating the flow rate of the sucked blood according to the product of the flow rate and the cross-sectional area of the suction pipeline, and stopping sucking and reminding under the condition that the flow rate exceeds a preset value.

Compared with the prior art, the invention has the following beneficial effects:

the invention can detect the pulse of the sucked object while sucking by the pulse pressure, synchronize the sucked pulse pressure with the contraction pressure of the pulse, and superimpose the adjustable pulse negative pressure synchronized with the human body vasoconstriction pressure on the set constant suction negative pressure so as to improve the suction efficiency and reduce the excessive blood loss flow velocity.

Drawings

Other features, objects and advantages of the present invention will become more apparent upon reading of the detailed description of non-limiting embodiments, given with reference to the accompanying drawings in which:

FIG. 1 is a schematic diagram of the structure of the present invention;

FIG. 2 is a schematic diagram of the present invention;

fig. 3 is a schematic diagram of a fluid flow sensor.

Detailed Description

The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the present invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications could be made by those skilled in the art without departing from the inventive concept. These are all within the scope of the present invention.

As shown in fig. 1, the invention provides a pumping device synchronous with pulse, which comprises a pumping pump 1, a pumping pipeline 4 and a pulse detection device 2. The pulse detection device is electrically connected with a controller 3 of the suction pump, provides working signals for the controller 3, and the suction pump sucks through a suction pipeline 4.

The suction pump can provide pulse pressure, and the controller 3 adjusts the pulse pressure according to the pulse signal detected by the pulse detection device 2, so that the pulse start time of the pulse pressure and the contraction pressure of the pulse are kept synchronous within a preset time error range. So as to reduce the instantaneous suction force, improve the suction efficiency and reduce the blood loss under the condition of equivalent average suction force. The synchronization function may select when to apply depending on the surgical needs. Pulse detection device 2 includes, but is not limited to, pressure, flow rate, microelectromechanical system, temperature differential, photoplethysmography (PPG), ultrasound, electrocardiography, and the like.

As shown in fig. 2, since the present embodiment is applied to the field of thrombus aspiration, negative pressure is required for aspiration. The pulse pressure includes a baseline pressure P0, and a pulse with a pressure variation dP superimposed on the baseline pressure P0, the baseline pressure P0 and the pressure variation dP being negative pressures. The baseline pressure P0, the pressure variation of the pulse, and the duration T may be adjusted according to actual conditions.

At time t, the force of aspiration of the thrombus is formed by the pressure difference across the thrombus, BP (t) +P0+dP (t), where BP is blood pressure, typically a function of positive pressure and time, P0 is the baseline pressure of the aspiration pump, adjustable constant negative pressure (DC), dP is the pulsed negative pressure superimposed on P0, with the onset time synchronized with BP (t) systolic pressure within the vessel. Wherein the shape of dP (t) can be controlled, for example, proportional to BP (t), square wave, triangular wave or the same as pulse signal. At baseline pressure, the thrombus is at rest, and is aspirated by the pulsed pressure.

The invention can be provided with a fluid flow rate sensor in the suction line. And calculating the flow rate of the suction fluid according to the product of the flow rate and the cross-sectional area of the suction pipeline.

As shown in fig. 3, the fluid flow rate sensor includes a heater 22, a first temperature sensor 21, and a second temperature sensor 23, and the heater 22, the first temperature sensor 21, and the second temperature sensor 23 are disposed on the same substrate 24 for ease of installation. The first temperature sensor 21 and the second temperature sensor 23 have a preset distance D therebetween, and the heater 22 is disposed at the first temperature sensor 21 or at a side of the first temperature sensor 21 away from the second temperature sensor 23.

The working principle of the fluid flow rate sensor is as follows:

The heater 22 heats the temperature of the fluid to be measured to generate a temperature pulse for the first temperature sensor 21 and the second temperature sensor 23 to detect, and since the heater 22 is disposed at the first temperature sensor 21 or on one side of the first temperature sensor 21 far away from the second temperature sensor 23, the first temperature sensor 21 can detect the temperature pulse earlier than the second temperature sensor 23, i.e. the time interval T between the first temperature sensor 21 and the second temperature sensor 23 detecting the temperature pulse is obtained.

Thereby obtaining the following steps:

the flow velocity v=d/T of the fluid to be measured, and the flow rate q=va of the fluid to be measured.

The first temperature sensor and the second temperature sensor of the invention are both semiconductor sensors, such as MEMS sensors. Meanwhile, the fluid flow rate sensor is packaged in a sheet-like structure so as to be mounted on the surface of the detecting device or embedded inside the pipeline.

The blood suction device can be used for sucking thrombus, and can be used for measuring the blood flow velocity, flow and resistance in a blood vessel or a cavity, so that the blood loss in the thrombus sucking process can be controlled in real time, the reduction of the hemoglobin concentration caused by the rise of the blood loss is reduced, and the occurrence rate of clinical adverse events of the suction operation is reduced.

The invention also provides a pulse synchronous pumping method, which comprises the pulse synchronous pumping equipment. In use, the pulse detection device is fixed on the sucked object to acquire the pulse signal of the sucked object. The baseline pressure and the pulse variation amount of the pulse pressure sucked by the suction pump are set according to the sucked object. The suction pump synchronizes the pulse start time of the pulse pressure and the systolic pressure of the pulse according to the pulse signal. And calculating the flow rate of the sucked blood according to the product of the flow rate and the cross-sectional area of the suction pipeline, and stopping suction and reminding when the flow rate exceeds a preset value.

In the description of the present application, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present application.

The foregoing describes specific embodiments of the present application. It is to be understood that the application is not limited to the particular embodiments described above, and that various changes or modifications may be made by those skilled in the art within the scope of the appended claims without affecting the spirit of the application. The embodiments of the application and the features of the embodiments may be combined with each other arbitrarily without conflict.

Claims (5)

1. A pumping device synchronous with pulse is characterized by comprising a pumping pump, a pumping pipeline and a pulse detection device;

The pulse detection device is electrically connected with a controller of the suction pump, and the suction pump sucks through the suction pipeline;

The suction pump provides a pulsed pressure;

the controller adjusts the pulse pressure according to the pulse signal detected by the pulse detection device, so that the pulse starting time of the pulse pressure and the contraction pressure of the pulse are kept synchronous within a preset time error range;

The pulse pressure comprises a baseline pressure P0 and a pulse with a pressure variation dP superimposed on the baseline pressure P0;

the baseline pressure P0, the pressure variance of the pulses, and the duration are adjustable;

The baseline pressure P0 and the pressure variation dP are both negative pressures;

At time t, the force for sucking thrombus is formed by the pressure difference between two ends of the thrombus, namely BP (t) +P0+dP (t);

Where BP is blood pressure, the start time of the pulse pressure is synchronized with the BP (t) systolic pressure within the blood vessel.

2. The pulse-synchronized aspiration device of claim 1, wherein the waveform of the pulse pressure is a square wave, a triangular wave, or the same waveform as the pulse signal.

3. The pulse-synchronized aspiration device of claim 1, wherein the pulse detection means comprises an electrocardiograph, a blood pressure monitor, a pressure sensor, a flow rate sensor, photoplethysmography, ultrasound, a flow sensor, or a microelectromechanical system.

4. The pulse synchronized aspiration device of claim 1, wherein a fluid flow sensor is disposed within the aspiration line;

in the case that the flow rate is detected to be slow, judging that an object is sucked into the suction pipeline;

The flow rate of the suction fluid is calculated from the product of the flow rate and the cross-sectional area of the suction line.

5. The pulse synchronized aspiration device of claim 4, wherein the fluid flow sensor comprises a heater, a first temperature sensor, and a second temperature sensor;

A preset distance D is arranged between the first temperature sensor and the second temperature sensor, the heater is arranged at the first temperature sensor or at one side of the first temperature sensor far away from the second temperature sensor;

The heater heats the temperature of the fluid to be detected to enable the fluid to be detected to generate temperature pulses for the first temperature sensor and the second temperature sensor to detect, so that a time interval T between the first temperature sensor and the second temperature sensor for detecting the temperature pulses is obtained;

Flow rate v=d/T of fluid.