CN113133745A - Sympathetic nerve chain nerve fiber positioning and mapping device - Google Patents
Sympathetic nerve chain nerve fiber positioning and mapping device Download PDFInfo
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- 230000002889 sympathetic effect Effects 0.000 title claims abstract description 123
- 210000005036 nerve Anatomy 0.000 title claims abstract description 115
- 210000004126 nerve fiber Anatomy 0.000 title claims abstract description 50
- 238000013507 mapping Methods 0.000 title claims abstract description 28
- 230000000638 stimulation Effects 0.000 claims abstract description 23
- 238000012545 processing Methods 0.000 claims description 26
- 230000008859 change Effects 0.000 claims description 17
- 238000001514 detection method Methods 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 9
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- 230000030214 innervation Effects 0.000 claims description 4
- 210000001617 median nerve Anatomy 0.000 claims description 3
- 230000001537 neural effect Effects 0.000 claims description 3
- 210000002321 radial artery Anatomy 0.000 claims description 3
- 238000002679 ablation Methods 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 10
- 238000011282 treatment Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000011298 ablation treatment Methods 0.000 description 1
- 210000003403 autonomic nervous system Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000008035 nerve activity Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
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- A61B5/48—Other medical applications
- A61B5/4887—Locating particular structures in or on the body
- A61B5/4893—Nerves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
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Abstract
The invention discloses a sympathetic nerve chain nerve fiber positioning and mapping device, which is characterized in that an electric pulse stimulation signal with preset intensity is released to a target sympathetic nerve chain measured point, then a first electrophysiological signal of a corresponding target sympathetic nerve chain dominant region is detected after the electric pulse stimulation signal is released, electrophysiological data of the target sympathetic nerve chain measured point can be obtained after the first electrophysiological signal is processed, and the electrophysiological data are displayed through a display unit, so that accurate positioning and mapping of sympathetic nerve chain nerve fibers are obtained, or an ablation effect is accurately evaluated in sympathetic nerve chain ablation and damage implementation.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a sympathetic nerve chain nerve fiber positioning and mapping device.
Background
Sympathetic nerves are part of the autonomic nervous system, and their activity mainly ensures the physiological needs of the body in a state of stress. Because the main trunk of the sympathetic nerve chain of the sympathetic nervous system is in a special anatomical position in a human body and is usually adjacent to important large blood vessels and organ tissues, the nerve regulation and control or damage operation aiming at the thoracic and lumbar sympathetic nerve chains has high clinical technical difficulty.
Currently, in some medical operations, it is often necessary to accurately position the sympathetic nerve chain nerve fibers, so that different tools are used to perform the cutting or ablation treatment on the sympathetic nerve chain nerve fibers to achieve the effect of treating diseases. For example, the current minimally invasive surgical technology based on the cavity mirror technology needs to observe and find the sympathetic nerve chain under direct vision to complete the subsequent surgical operation; the interventional technique is to perform intraoperative image-guided positioning by using the anatomical research basis of the sympathetic nerve chain, and if the position of the sympathetic nerve chain is changed, the ideal clinical treatment effect cannot be obtained.
Therefore, how to provide a device capable of locating and mapping the position of nerve fibers of a sympathetic nerve chain is a technical problem to be solved by those skilled in the art.
Disclosure of Invention
In order to solve the technical problem, the invention provides a sympathetic nerve chain nerve fiber positioning and mapping device which can position and map sympathetic nerve chain nerve fibers.
The invention provides a sympathetic nerve chain nerve fiber positioning and mapping device, which comprises:
the electric pulse generating unit is used for generating an electric pulse stimulation signal with preset intensity;
the electric pulse releasing unit is used for releasing an electric pulse stimulation signal to a target sympathetic nerve chain measured point and is connected with the electric pulse generating unit;
the first detection unit is used for detecting a first electrophysiological signal generated by a target sympathetic nerve chain dominant region corresponding to a target sympathetic nerve chain measured point after releasing the electric pulse stimulation signal;
the signal processing unit is used for processing the first electrophysiological signal and outputting a processing result;
and the display unit is used for displaying the processing result.
Preferably, the signal processing unit is specifically configured to process the first electrophysiological signal, calculate a rate of change of intensity of the first electrophysiological signal, and output a first prompt signal when the rate of change of intensity of the first electrophysiological signal is greater than or equal to a first threshold; wherein the first prompt signal is used for prompting that the target sympathetic nerve chain measured point is located in the region of the target sympathetic nerve chain nerve fiber.
Preferably, the sympathetic nerve chain nerve fiber location mapping device further comprises a second detection unit;
the second detection unit is used for detecting a second electrophysiological signal of the target sympathetic nerve chain measured point;
the signal processing unit is further configured to process the second electrophysiological signal, calculate a rate of change of intensity of the second electrophysiological signal, and output a second prompt signal when the rate of change of intensity of the second electrophysiological signal is greater than or equal to a second threshold; wherein the second prompt signal is used for prompting that the target sympathetic nerve chain measured point is located in a target tissue region.
Preferably, the signal processing unit is further adapted to,
when the intensity value of the first electrophysiological signal is within a first preset range and the intensity value of the second electrophysiological signal is within a second preset range, outputting a third prompt signal; and the third prompt signal is used for prompting that the target sympathetic nerve chain measured point is located in the region of the target sympathetic nerve chain main stem.
Preferably, the first electrophysiological signal comprises a neural action potential signal.
Preferably, the second electrophysiological signal comprises an impedance signal.
Preferably, the second electrophysiological signal further comprises a temperature signal.
Preferably, the target sympathetic chain innervation region comprises one or more of a skin surface, a median nerve, and a radial artery vessel wall.
The invention provides a sympathetic nerve chain nerve fiber positioning and mapping device, which is characterized in that an electric pulse stimulation signal with preset intensity is released to a target sympathetic nerve chain measured point, then a first electrophysiological signal of a corresponding target sympathetic nerve chain dominant region is detected after the electric pulse stimulation signal is released, electrophysiological data of the target sympathetic nerve chain measured point can be obtained after the first electrophysiological signal is processed, and the electrophysiological data are displayed through a display unit, so that accurate positioning and mapping of sympathetic nerve chain nerve fibers are obtained, or an ablation effect is accurately evaluated in sympathetic nerve chain ablation and damage implementation.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present application, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic structural diagram of a sympathetic nerve chain nerve fiber location mapping device according to an embodiment of the present invention.
Detailed Description
In order to make those skilled in the art better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments.
It will be understood that when an element is referred to as being "fixed" or "disposed" on another element, it can be directly on the other element or be indirectly disposed on the other element; when an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.
It will be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like, refer to an orientation or positional relationship illustrated in the drawings for convenience in describing the present application and to simplify description, and do not indicate or imply that the system or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be considered limiting of the present application.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, the meaning of a plurality of or a plurality of is two or more unless specifically limited otherwise.
It should be understood that the structures, ratios, sizes, and the like shown in the drawings and described in the specification are only used for understanding and reading the contents disclosed in the specification, and are not used for limiting the conditions that the present application can implement, so the present invention has no technical significance, and any structural modification, ratio relationship change or size adjustment should still fall within the scope of the technical content disclosed in the present application without affecting the efficacy and the achievable purpose of the present application.
Referring to fig. 1, a schematic structural diagram of a sympathetic nerve chain nerve fiber positioning and mapping device according to an embodiment of the present invention is shown. The device includes:
an electric pulse generating unit 100 for generating an electric pulse stimulation signal of a preset intensity;
the electric pulse releasing unit 200 is used for releasing an electric pulse stimulation signal to a target sympathetic nerve chain measured point, and the electric pulse releasing unit 200 is connected with the electric pulse generating unit 100;
the first detection unit 300 is used for detecting a first electrophysiological signal generated by a target sympathetic nerve chain dominant region corresponding to a target sympathetic nerve chain measured point after releasing the electric pulse stimulation signal;
a signal processing unit 400, configured to process the first electrophysiological signal and output a processing result;
and a display unit 500 for displaying the processing result.
In the embodiment of the present invention, the electric pulse generating unit 100 is capable of generating an electric pulse stimulation signal with a predetermined intensity. The frequency and the intensity of the electric pulse stimulation signals can be preset according to target sympathetic nerve chain nerve fibers which need to be detected actually.
The electric pulse releasing unit 200 is electrically connected to the electric pulse generating unit 100, and can release the electric pulse stimulation signal generated by the electric pulse generating unit 100 to the target sympathetic nerve chain measured point. In specific implementation, the electric pulse releasing unit 200 may be attached to a component having a puncturing part to facilitate puncturing into the vicinity of the target sympathetic nerve chain nerve fiber in the body of the subject.
When the measured point of the target sympathetic nerve chain is released with the electric pulse stimulation signal, an electrophysiological signal is generated in the corresponding target sympathetic nerve chain dominant region, and the first electrophysiological signal of the target sympathetic nerve chain dominant region can be detected by the first detecting unit 300. Specifically, the target sympathetic nerve chain innervation region is a region innervated by the target sympathetic nerve chain, i.e., a target sympathetic nerve peripheral nerve region.
The signal processing unit 400 is connected to the first detecting unit 300, processes the first electrophysiological signal detected by the first detecting unit 300 to obtain electrophysiological data of a target sympathetic nerve chain measured point, outputs a corresponding processing result, and displays the processing result on the display unit 500, so as to obtain accurate positioning and mapping of sympathetic nerve chain nerve fibers, or accurately evaluate an ablation effect in a sympathetic nerve chain ablation and damage operation.
As can be seen from the above, the sympathetic nerve chain nerve fiber positioning and mapping device provided in the embodiment of the present invention releases an electric pulse stimulation signal with a preset intensity to a target sympathetic nerve chain measured point, then detects a corresponding first electrophysiological signal of a target sympathetic nerve chain dominant region after releasing the electric pulse stimulation signal, and after processing the first electrophysiological signal, obtains electrophysiological data of the target sympathetic nerve chain measured point, and displays the electrophysiological data through the display unit, thereby obtaining accurate positioning and mapping of sympathetic nerve chain nerve fibers, or accurately evaluating an ablation effect in a sympathetic nerve chain ablation and damage operation.
Preferably, the first electrophysiological signal includes a neural action potential signal, the target sympathetic chain innervation region includes one or more of a skin surface, a median nerve, and a radial artery vessel wall. In this embodiment, the first detecting unit 300 punctures or attaches to a corresponding area on the skin surface to detect the target sympathetic nerve action potential signal caused by the electrical pulse stimulation signal released from the target sympathetic nerve chain measured point.
Specifically, in the above embodiment, the signal processing unit 400 is specifically configured to process the first electrophysiological signal, calculate an intensity change rate of the first electrophysiological signal, and output the first prompt signal when the intensity change rate of the first electrophysiological signal is greater than or equal to the first threshold; the first prompt signal is used for prompting that the target sympathetic nerve chain measured point is located in the region where the target sympathetic nerve chain nerve fiber is located.
In the embodiment of the present invention, after an electric pulse stimulation signal with the intensity change rate greater than or equal to a preset value is released to a target sympathetic nerve chain measured point, the signal processing unit 400 calculates the intensity change rate of the first electrophysiological signal detected by the first detecting unit 300, and when the intensity change rate of the first electrophysiological signal is greater than or equal to a first threshold, it indicates that the target sympathetic nerve chain measured point is located in an area where a target sympathetic nerve chain nerve fiber is located, and at this time, outputs a first prompt signal, thereby implementing positioning and mapping of the target sympathetic nerve chain nerve fiber. It can be understood that when the above conditions are not met, the detected point of the target sympathetic nerve chain deviates from the region where the nerve fiber of the target sympathetic nerve chain is located, and the detected point needs to be replaced; or, no target sympathetic nerve chain nerve fiber exists at the target sympathetic nerve chain measured point, which shows that the sympathetic nerve chain ablation and damage operation has a good ablation effect.
In specific implementation, the intensity value of the released electrical pulse stimulation signal needs to be within a certain intensity interval, the intensity value of the detected first electrophysiological signal also needs to be within a certain intensity interval, otherwise, signal distortion is caused, and the detection result is inaccurate.
Further, since the area of the target sympathetic nerve chain nerve fiber is relatively small, it is difficult to quickly and accurately locate the target sympathetic nerve chain measured point to the area of the target sympathetic nerve chain nerve fiber. Therefore, in some optional embodiments of the present invention, the sympathetic nerve chain nerve fiber location mapping device further comprises a second detection unit 600, wherein the second detection unit 600 is configured to detect a second electrophysiological signal of the target sympathetic nerve chain measured point; the signal processing unit 400 is further configured to process the second electrophysiological signal, calculate a rate of change of the intensity of the second electrophysiological signal, and output a second prompt signal when the rate of change of the intensity of the second electrophysiological signal is greater than or equal to a second threshold; and the second prompt signal is used for prompting that the target sympathetic nerve chain measured point is located in the target tissue region.
In the embodiment of the present invention, the target sympathetic nerve chain nerve fibers exist in the physiological tissue of the subject to be tested, the physiological tissue of the subject to be tested itself has electrophysiological signals, the signal processing unit 400 calculates the second electrophysiological signal of the target sympathetic nerve chain measured point detected by the second detecting unit 600, and when the change rate of the intensity of the detected second electrophysiological signal is greater than or equal to the second threshold, it indicates that the target sympathetic nerve chain measured point is located in the target tissue region, where the target tissue region refers to the physiological tissue region where the target sympathetic nerve chain nerve fibers exist, and at this time, the second prompt signal is output, so as to more quickly realize the positioning and mapping of the target sympathetic nerve chain nerve fibers. It can be understood that when the above conditions are not satisfied, the deviation of the target sympathetic nerve chain measured point from the physiological tissue of the measured object is indicated, and the measured point needs to be positioned to the physiological tissue of the measured object first, and then the target sympathetic nerve chain nerve fiber can be further positioned to the area.
In specific implementation, the intensity value of the detected second electrophysiological signal should be within a certain intensity interval, otherwise, signal distortion is also caused, and the detection result is inaccurate. Alternatively, the second detecting unit 600 and the electric pulse releasing unit 200 may be attached to a member having a puncturing part at the same time, so as to facilitate puncturing into the vicinity of the target sympathetic nerve chain nerve fiber in the body of the subject.
Preferably, the second electrophysiological signal comprises an impedance signal. In this embodiment, the second detection unit 600 detects an impedance signal of the measured point by penetrating into the vicinity of the sympathetic nerve chain nerve fiber in the body of the measured object.
Furthermore, since the area of the physiological tissue where the target sympathetic nerve chain nerve fiber is located is relatively large, when the detection point is positioned in the physiological tissue of the measured object, it is still difficult to quickly further locate the area where the target sympathetic nerve chain nerve fiber is located. Therefore, in some optional embodiments of the present invention, the signal processing unit 400 is further configured to output a third prompt signal when the intensity value of the first electrophysiological signal is within a first preset range and the intensity value of the second electrophysiological signal is within a second preset range; and the third prompt signal is used for prompting that the target sympathetic nerve chain measured point is located in the region of the target sympathetic nerve chain main stem.
In the embodiment of the invention, the target sympathetic nerve chain nerve fiber exists in the region of the main stem of the target sympathetic nerve chain of the tested object, and the region of the main stem of the target sympathetic nerve chain exists in the physiological tissue of the tested object. Therefore, after the detection point is positioned in the physiological tissue of the measured object, an electric pulse stimulation signal with preset intensity is released to the measured point of the target sympathetic nerve chain, when the intensity value of the detected first electrophysiological signal is within a first preset range and the intensity value of the detected second electrophysiological signal is within a second preset range, the measured point of the target sympathetic nerve chain is positioned in the region where the main trunk of the target sympathetic nerve chain is located, a third prompt signal is output at the moment, and then the target sympathetic nerve chain can be further positioned in the region where the target sympathetic nerve chain nerve fibers are located, so that the positioning and mapping of the target sympathetic nerve chain nerve fibers are more quickly realized.
Preferably, the second electrophysiological signal further comprises a temperature signal. In this embodiment, in the instant evaluation of the treatment effect of the sympathetic nerve chain ablation and damage, the second detection unit 600 may also monitor the local temperature of the physiological tissue of the object to be measured in real time, so as to evaluate the treatment effect of the sympathetic nerve chain ablation and damage more accurately.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (8)
1. A sympathetic nerve chain nerve fiber location and mapping device is characterized by comprising:
the electric pulse generating unit is used for generating an electric pulse stimulation signal with preset intensity;
the electric pulse releasing unit is used for releasing an electric pulse stimulation signal to a target sympathetic nerve chain measured point and is connected with the electric pulse generating unit;
the first detection unit is used for detecting a first electrophysiological signal generated by a target sympathetic nerve chain dominant region corresponding to a target sympathetic nerve chain measured point after releasing the electric pulse stimulation signal;
the signal processing unit is used for processing the first electrophysiological signal and outputting a processing result;
and the display unit is used for displaying the processing result.
2. The sympathetic nerve chain nerve fiber location mapping device of claim 1,
the signal processing unit is specifically configured to process the first electrophysiological signal, calculate a rate of change of intensity of the first electrophysiological signal, and output a first prompt signal when the rate of change of intensity of the first electrophysiological signal is greater than or equal to a first threshold; wherein the first prompt signal is used for prompting that the target sympathetic nerve chain measured point is located in the region of the target sympathetic nerve chain nerve fiber.
3. The sympathetic nerve chain nerve fiber location mapping device of claim 2, further comprising a second detection unit;
the second detection unit is used for detecting a second electrophysiological signal of the target sympathetic nerve chain measured point;
the signal processing unit is further configured to process the second electrophysiological signal, calculate a rate of change of intensity of the second electrophysiological signal, and output a second prompt signal when the rate of change of intensity of the second electrophysiological signal is greater than or equal to a second threshold; wherein the second prompt signal is used for prompting that the target sympathetic nerve chain measured point is located in a target tissue region.
4. The sympathetic nerve chain nerve fiber location mapping device of claim 3, wherein the signal processing unit is further configured to,
when the intensity value of the first electrophysiological signal is within a first preset range and the intensity value of the second electrophysiological signal is within a second preset range, outputting a third prompt signal; and the third prompt signal is used for prompting that the target sympathetic nerve chain measured point is located in the region of the target sympathetic nerve chain main stem.
5. The sympathetic chain nerve fiber location mapping device of claim 1, wherein the first electrophysiological signal comprises a neural action potential signal.
6. The sympathetic chain nerve fiber location mapping device of claim 3, wherein the second electrophysiological signal comprises an impedance signal.
7. The sympathetic chain nerve fiber location mapping device of claim 6, wherein the second electrophysiological signal further includes a temperature signal.
8. The sympathetic chain nerve fiber location mapping device of claim 1, wherein the target sympathetic chain innervation region comprises one or more of a skin surface, a median nerve, and a radial artery vessel wall.
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| CN202110483865.8A CN113133745A (en) | 2021-04-30 | 2021-04-30 | Sympathetic nerve chain nerve fiber positioning and mapping device |
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