CN113069645A

CN113069645A - Radiopharmaceutical atomization system

Info

Publication number: CN113069645A
Application number: CN202110434313.8A
Authority: CN
Inventors: 田海滨; 彭星星
Original assignee: Hubei Topgene Biological Technology Co ltd
Current assignee: Hubei Topgene Biological Technology Co ltd
Priority date: 2021-04-21
Filing date: 2021-04-21
Publication date: 2021-07-06

Abstract

The present invention provides a radiopharmaceutical aerosolization system comprising: the radiation-proof container comprises a box body and a cover body, wherein the box body is provided with a box body opening, the cover body can seal the box body opening and is detachably connected with the box body opening, and the radiation-proof container is made of Pb; one or more atomizing cups disposed within the cartridge body; the atomizer is connected with the atomizing cup in a one-to-one correspondence manner through a conduit; and one or more breathing masks arranged outside the box body, wherein the breathing masks are connected with the atomizing cups in a one-to-one correspondence manner through guide pipes. Compared with the prior art, the invention has the beneficial effects that: the anti-radiation container made of Pb isolates the atomizing cup, so that the atomizing process occurs in the container with the anti-radiation function, the leakage of radioactive substances is avoided, and the safety of the experiment is ensured.

Description

Radiopharmaceutical atomization system

Technical Field

The invention belongs to the field of experimental devices, and particularly relates to a radiopharmaceutical atomization system.

Background

Understanding the effect of pharmaceutical dosage forms in human body has been an important challenge of pharmaceutical science, wherein radionuclide imaging technology has become one of its important research means, and its method is generally to try different administration routes to a test body after introducing gamma-ray-releasing radionuclide into the drug, so as to find out its specific transformation process and route, and finally determine the effective administration route according to the radioactive element tracing result.

The development of drugs administered by the pulmonary and nasal routes by nebulization is currently an emerging direction, particularly in respiratory diseases, where confirmation of drug delivery to the entire lung or specific lung regions, or confirmation of subsequent deposition and clearance of the drug formulation in the nasal cavity, is an important factor in the development of such drugs. The radioactive tracer is combined with the PET/CT imaging technology to be an important means for obtaining the experimental data, but the radioactive reagent has great hidden danger of radioactive leakage under the condition of atomization respiration, and particularly, when atomization is carried out, the probability of nuclear substance leakage is higher due to violent liquid or gas impact, so that the safety of the experiment cannot be ensured.

Disclosure of Invention

In order to solve the technical problem, the invention provides a radiopharmaceutical atomization system.

The specific technical scheme is as follows:

a radiopharmaceutical aerosolization system, distinct therefrom, comprising:

the radiation-proof container comprises a box body and a cover body, wherein the box body is provided with a box body opening, the cover body can seal the box body opening and is detachably connected with the box body opening, and the radiation-proof container is made of Pb;

one or more atomizing cups disposed within the cartridge body;

the atomizer is connected with the atomizing cup in a one-to-one correspondence manner through a conduit;

and

and one or more breathing masks arranged outside the box body, wherein the breathing masks are in one-to-one correspondence with the atomizing cups through guide pipes.

Compared with the prior art, the invention has the beneficial effects that: the anti-radiation container made of Pb isolates the atomizing cup, so that the atomizing process occurs in the container with the anti-radiation function, the leakage of radioactive substances is avoided, and the safety of the experiment is ensured.

Further, the radiopharmaceutical atomization system also comprises a vacuumizing device connected with the radiation-proof container, and the vacuumizing device is arranged outside the box body.

The beneficial effect of adopting the further technical scheme is that: the radiation-proof container is in negative pressure through the vacuumizing device, so that the tightness of the cover body and the box body can be improved, and the radioactive substances can be further prevented from leaking.

Further, a buffer container is connected between the radiation-proof container and the vacuumizing device, the radiation-proof container is connected with the buffer container through a first pipeline, the buffer container is connected with the vacuumizing device through a second pipeline, and a gas valve is mounted on the first pipeline and the second pipeline; the buffer container is made of Pb.

The beneficial effect of adopting the further technical scheme is that: the radioactive reagent in the radiation-proof container is prevented from entering the vacuum pump.

Further, a sealing layer is arranged on the box body along the edge of the opening of the box body; when the cover body seals the opening of the box body, the cover body is in contact with the sealing layer; the sealing layer is made of rubber.

The beneficial effect of adopting the further technical scheme is that: the sealing layer prepared by rubber can further increase the sealing property of the cover body and the box body.

Furthermore, a plurality of through holes are formed in the box body, the guide pipe is connected with the atomizing cup through the through holes, and the guide pipe comprises a first soft rubber section, a first sealing section and a second soft rubber section which are sequentially connected; the first sealing section is connected with the through hole through a threaded structure, and the first sealing section is made of Pb.

The beneficial effect of adopting the further technical scheme is that: the first sealing section made of Pb can leak radiation at the through hole and play a role in fixing the guide pipe.

Furthermore, the box body comprises a box body bottom surface which is arranged opposite to the box body opening, one or more atomizing cup solid cavities are arranged on the box body bottom surface, and the atomizing cups are arranged in the solid cavities.

The beneficial effect of adopting the further technical scheme is that: the atomizing cup solid cavity can prevent the atomizing cup from being placed unstably.

Further, a handle is installed on the cover body.

The beneficial effect of adopting the further technical scheme is that: the convenience in operation is increased.

Further, the first pipeline comprises a first buffer container connecting section and the radiation-proof container connecting section, the first buffer container connecting section is connected with the buffer container through a threaded structure, the radiation-proof container connecting section is connected with the cover body through a threaded structure, and the buffer container connecting section and the radiation-proof container connecting section are made of Pb; the second pipeline includes second buffer container linkage segment, the second buffer container linkage segment with buffer container adopts the helicitic texture to connect, the material of second buffer container linkage segment is Pb.

The beneficial effect of adopting the further technical scheme is that: preventing radiation leakage at the pipe joints.

Further, the radiation protection container is a cuboid, the length of the inside of the radiation container is 250 mm-350 mm, the height of the inside of the radiation container is 150 mm-250 mm, and the width of the inside of the radiation container is 60 mm-80 mm.

Furthermore, the box body comprises two oppositely arranged side bodies and a bottom side vertically connected with the two side bodies, and the thicknesses of the side bodies, the bottom side and the cover body are 45-55 mm.

The beneficial effect of adopting the further technical scheme is that: the nuclear protection effect can be further ensured.

Drawings

FIG. 1 is a schematic view of a radiopharmaceutical aerosolization system;

FIG. 2 is a schematic view of a radiation protective container;

FIG. 3 is a schematic view of the opening of the case;

FIG. 4 is a bottom view of the case;

fig. 5 is a schematic view of a catheter structure.

In the drawings, the components represented by the respective reference numerals are listed below:

the device comprises a radiation-proof container-1, an atomizing cup-2, an atomizer-3, a breathing mask-4, a conduit-5, a vacuumizing device-6, a buffer container-7, a first pipeline-8, a second pipeline-9, an atomizing cup solid cavity-10, a handle-11, a gas valve-12, a box body-101, a cover body-102, a sealing layer-103, a box body opening-1011, a side body-101 a, a bottom side-101 b, a box body bottom surface-1012, a through hole-1013, a first soft rubber section-501, a first sealing section-502, a second soft rubber section-503, a first buffer container connecting section-801, a radiation-proof container connecting section-802 and a second buffer container connecting section-901.

Detailed Description

The principles and features of this invention are described below in conjunction with the following drawings, which are set forth by way of illustration only and are not intended to limit the scope of the invention.

Example 1

The present embodiment provides a radiopharmaceutical atomizing system, which is schematically shown in fig. 1 to 5:

the radiation-proof container 1 comprises a box body 101 and a cover body 102, wherein the box body 101 is provided with a box body opening 1011, the cover body 102 can seal the box body opening 1011 and is detachably connected with the box body 101, the radiation-proof container 1 is made of Pb, the box body comprises two oppositely arranged side bodies 101a and a bottom side 101b vertically connected with the two side bodies, and the thicknesses of the side bodies 101a, the bottom side 101b and the cover body 102 are 45-55 mm. Two atomizing cups 2 arranged in the box body; the two atomizers 3 are arranged outside the box body 101, and the atomizers 3 are correspondingly connected with the atomizing cups 2 one by one through the guide pipes 5; two respiratory masks 4 arranged outside the box body 101, wherein the respiratory masks 4 are correspondingly connected with the atomizing cups 2 one by one through the guide pipes 5.

After a sample containing radioactive reagents is added into the atomizing cup 2, the box body 101 is sealed by the cover body 102, the atomizer 3 is opened, medicines in the atomizing cup 2 are atomized, the atomized medicines are input into an experimental body with the breathing mask 4 through the pipeline 5, and the step with the highest radioactive substance leakage risk is carried out in the radiation-proof container with the radiation-proof function, so that the safety of the experimental body is improved.

In this embodiment, the radiopharmaceutical atomization system further comprises a vacuum extractor 6 connected to the radiation-proof container 1, and the vacuum extractor 6 is disposed outside the cassette body.

Evacuating device 6 can carry out evacuation processing with radiation protection container 1, for the radioactive container provides little negative pressure environment, and the negative pressure is too big, probably causes the reagent blowout in atomizing cup 2, avoids the inside gas of box body to outwards reveal, further strengthens the security.

In the embodiment, a buffer container 7 is further connected between the radiation-proof container 1 and the vacuum extractor 6, the radiation-proof container 1 is connected with the buffer container 7 through a first pipeline 8, the buffer container 7 is connected with the vacuum extractor 6 through a second pipeline 9, and a gas valve 12 is mounted on the first pipeline 8 and the second pipeline 9; the buffer container is made of Pb.

Before atomization, vacuumizing treatment is carried out, meanwhile, gas valves 12 on a first pipeline 8 and a second pipeline 9 are opened, the valves 12 on the second pipeline 9 are closed by observing the pressure value of the vacuumizing device until the pressure reaches a set value, then the vacuumizing device 6 is closed, and during the operation period of the buffer container 7, the reagent of an atomizing cup can be prevented from being sprayed out due to too low pressure in the radiation-proof container 1, the sprayed reagent can be collected in the buffer container 7, and the reagent can be prevented from entering the vacuumizing device 6 as much as possible; and in the experiment finishing stage, the valve 12 on the first pipeline 8 can be closed, the valve 12 and the vacuumizing device 6 on the second pipeline 9 are opened, the buffer container 7 is vacuumized to the set pressure intensity, the vacuumizing device 6 and the valve on the second pipeline 9 are sequentially closed, the valve 12 of the first pipeline 8 is opened, and the gas after the experiment is finished is sucked again and enters the buffer container 7. The design of the buffer container 7 makes it possible to avoid leakage of nuclear radiation agent in a two-stage operation.

In this embodiment, the box 101 is provided with a sealing layer 103 along the edge of the box opening 1011; when the lid 102 seals the box opening 1011, the lid 102 contacts the sealing layer 103; the sealing layer 103 is made of rubber.

Under the action of the vacuum-pumping device, the cover body 102 can be closely adsorbed with the sealing layer 103 made of rubber, so that the air tightness is further enhanced.

In this embodiment, the box body 101 is provided with through holes corresponding to the number of the guide pipes 5, the guide pipes 5 are connected with the atomizing cup 2 through the through holes 1013, and each guide pipe 5 comprises a first soft rubber section 501, a first sealing section 502 and a second soft rubber section 503 which are sequentially connected; the first sealing section is connected with the through hole through a threaded structure, and the first sealing section is made of Pb.

The segmented design of the conduit 5 can be sealed by the through hole of the first sealing section 502, so as to prevent the radioactive agent from leaking, and the first sealing section 502 can also play a role in supporting the whole conduit 5.

In this embodiment, the bottom side 101b comprises a cartridge bottom surface 1012 arranged opposite to the cartridge opening 1011, two atomizing cup solid chambers 10 being arranged on the cartridge bottom surface 1012, and the atomizing cup 2 being arranged in the atomizing cup solid chamber 10.

In the present embodiment, the handle 11 is attached to the cover 102.

In this embodiment, the first pipeline 8 includes a first buffer container connection section 801 and a radiation-proof container connection section 802, the first buffer container connection section 801 is connected with the buffer container 7 by a screw structure, the radiation-proof container connection section 802 is connected with the cover 102 by a screw structure, and the first buffer container connection section 801 and the radiation-proof container connection section 802 are made of Pb; the second pipeline 9 comprises a second buffer container connecting section 901, the second buffer container connecting section 901 is connected with the buffer container 7 through a threaded structure, and the second buffer container connecting section is made of Pb.

In the implementation, the radiation-proof container is a cuboid, the length of the interior of the radiation-proof container is 250-350 mm, the height of the radiation-proof container is 150-250 mm, and the width of the radiation-proof container is 60-80 mm;

in this embodiment, the atomizing cup and the atomizer are both commercially available products.

The using method of the device comprises the steps of assembling the system, placing the atomizing cup 2 in the box body 101, adding a reagent containing radioactive elements into the atomizing cup, and then sealing the box body 102 by the cover body 102;

vacuumizing, opening gas valves on the first pipeline 8 and the second pipeline 9 simultaneously, closing the valve on the second pipeline 9 by observing the pressure value of the vacuumizing device 6 until the pressure reaches a set value, and then closing the vacuumizing device 6;

the respiratory mask 4 is worn on the experimental body, and the atomizer 3 is started to atomize the medicine in the atomizing cup 2 to supply medicine to the experimental body;

after the medicine supply is finished, the experiment is finished, the valve 12 on the first pipeline 8 can be closed, the valve 12 and the vacuumizing device 6 on the second pipeline 9 are opened, the buffer container 7 is vacuumized to the set pressure intensity, the valve 12 on the vacuumizing device 6 and the valve 12 on the second pipeline 9 are sequentially closed, the valve 12 of the first pipeline 8 is opened, and the gas after the experiment is sucked again enters the buffer container 7.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims

1. a radiopharmaceutical atomization system, is characterized in that, comprises:

A radiation protection container, the radiation protection container includes a box body and a cover body, the box body is provided with a box body opening, and the cover body can close the box body opening and be detachably connected with the box body opening, so The material of the radiation-proof container is Pb;

one or more atomizing cups placed in the box;

One or more nebulizers placed outside the box, and the nebulizer and the nebulizing cup are connected in a one-to-one correspondence through a conduit;

and

One or more breathing masks placed outside the box, the breathing masks and the atomizing cup are connected in a one-to-one correspondence with the nebulizer cup.

2 . The radiopharmaceutical atomization system according to claim 1 , wherein the radiopharmaceutical atomization system further comprises a vacuuming device connected with the radiation protection container, and the vacuuming device is placed in the box. 3 . in vitro.

3 . The radiopharmaceutical atomization system according to claim 2 , wherein a buffer container is also connected between the radiation protection container and the vacuuming device, and the radiation protection container and the buffer container pass through the first A pipeline is connected, the buffer container and the vacuuming device are connected through a second pipeline, and a gas valve is installed on the first pipeline and the second pipeline; the material of the buffer container is Pb.

4 . The radiopharmaceutical atomization system according to claim 1 , wherein the box body is provided with a sealing layer along the edge of the box body opening; when the cover body seals the box body opening, the The cover body is in contact with the sealing layer; the material of the sealing layer is rubber.

5 . The radiopharmaceutical atomization system according to claim 1 , wherein a plurality of through holes are opened on the box body, and the conduit is connected to the atomizing cup through the through holes, and the conduit comprises sequential The first soft rubber section, the first sealing section and the second soft rubber section are connected; the first sealing section is connected with the through hole through a threaded structure, and the material of the first sealing section is Pb.

6 . The radiopharmaceutical atomization system according to claim 1 , wherein the box body comprises a box body bottom surface arranged opposite to the box body opening, and one or more box body bottom surfaces are provided on the box body bottom surface. 7 . Atomization cup solid cavity, the atomization cup is placed in the solid cavity.

7 . The radiopharmaceutical atomization system according to claim 1 , wherein a handle is installed on the cover. 8 .

8 . The radiopharmaceutical atomization system according to claim 3 , wherein the first pipeline comprises a first buffer container connecting section and the radiation protection container connecting section, and the first buffer container connecting section is connected to the The buffer container is connected by a threaded structure, the connection section of the radiation protection container is connected with the cover body by a threaded structure, and the material of the connection section of the first buffer container and the connection section of the radiation protection container is Pb; the second connection section is made of Pb; The pipeline includes a second buffer container connection section, the second buffer container connection section is connected with the buffer container by a threaded structure, and the material of the second buffer container connection section is Pb.

9 . The radiopharmaceutical atomization system according to claim 1 , wherein the radiation protection container is a rectangular parallelepiped, the length of the interior of the radiation container is 250 mm˜350 mm, and the height of the interior of the radiation container is 150 mm. 10 . ~250mm, the width of the inside of the radiation container is 60mm ~ 80mm.

10. The radiopharmaceutical atomization system according to claim 1, wherein the box body comprises two oppositely arranged side bodies and a bottom side vertically connected to the two side bodies, the side bodies, The thickness of the bottom side and the cover body is 45 mm to 55 mm.