CN113017935A - Anti-fatigue fracture bionic intervertebral disc - Google Patents
Anti-fatigue fracture bionic intervertebral disc Download PDFInfo
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- CN113017935A CN113017935A CN202110249680.0A CN202110249680A CN113017935A CN 113017935 A CN113017935 A CN 113017935A CN 202110249680 A CN202110249680 A CN 202110249680A CN 113017935 A CN113017935 A CN 113017935A
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- end plate
- intervertebral disc
- core
- fatigue fracture
- elastic modulus
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- 239000011664 nicotinic acid Substances 0.000 title claims abstract description 13
- 230000002929 anti-fatigue Effects 0.000 title claims abstract description 7
- 229920001971 elastomer Polymers 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 17
- 239000004433 Thermoplastic polyurethane Substances 0.000 claims abstract description 9
- 239000000806 elastomer Substances 0.000 claims abstract description 9
- 229920002803 thermoplastic polyurethane Polymers 0.000 claims abstract description 9
- 239000000835 fiber Substances 0.000 claims description 12
- 239000011248 coating agent Substances 0.000 claims description 11
- 238000000576 coating method Methods 0.000 claims description 11
- 239000002861 polymer material Substances 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 3
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 230000007423 decrease Effects 0.000 claims description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 3
- 229920002530 polyetherether ketone Polymers 0.000 claims description 3
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 claims description 3
- 230000007774 longterm Effects 0.000 abstract description 4
- 230000035882 stress Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 238000005452 bending Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 208000021600 intervertebral disc degenerative disease Diseases 0.000 description 2
- 230000000379 polymerizing effect Effects 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010061246 Intervertebral disc degeneration Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 208000018180 degenerative disc disease Diseases 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30014—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30518—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements with possibility of relative movement between the prosthetic parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/3093—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth for promoting ingrowth of bone tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
- A61F2310/00407—Coating made of titanium or of Ti-based alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
本发明公开了一种抗疲劳断裂仿生椎间盘，由上终板、下终板和位于上终板和下终板之间的核心构成，上终板上部和下终板下部分别设置有尖刺用于实现与椎骨的固定。核心两端分别固定于上终板下部和下终板上部。核心包括髓核和纤维环，髓核为热塑性聚氨酯弹性体橡胶材料，纤维环为功能梯度材料，由两种或多种不同模量热塑性聚氨酯弹性体橡胶材料聚合构成，具有类似人体生物椎间盘的梯度特征，能有效避免人工椎间盘产品在长期往复运动过程中疲劳断裂。同时通过核心的变形，上终板和下终板能够产生相对运动，模拟实现人体椎间盘的生理运动特征。
The invention discloses an anti-fatigue fracture bionic intervertebral disc, which is composed of an upper end plate, a lower end plate and a core located between the upper end plate and the lower end plate. to achieve fixation with the vertebrae. The two ends of the core are respectively fixed on the lower part of the upper end plate and the upper part of the lower end plate. The core includes a nucleus pulposus and an annulus fibrosus, the nucleus pulposus is a thermoplastic polyurethane elastomer rubber material, and the fibrous annulus is a functionally graded material, which is composed of two or more thermoplastic polyurethane elastomer rubber materials with different moduli. It has a gradient similar to that of a human biological intervertebral disc. It can effectively avoid fatigue fracture of artificial intervertebral disc products during long-term reciprocating motion. At the same time, through the deformation of the core, the upper endplate and the lower endplate can produce relative motion, simulating the physiological motion characteristics of the human intervertebral disc.
Description
Technical Field
The invention relates to a fatigue fracture resistant bionic intervertebral disc, and belongs to the technical field of medical instruments.
Background
The intervertebral disc is an important part of the spine of a human body, and with the increase of the age, the gradual aging or damage of the intervertebral disc of the human body can cause single-segment or multi-segment intervertebral disc degenerative diseases, so that continuous pain is caused, the intervertebral disc becomes one of main skeletal muscular system diseases in the world, the life quality of a patient is seriously influenced, and a heavy economic burden is brought to the family of the patient. Currently, disc replacement is an effective method for treating degenerative disc disease, and has the functions of maintaining intervertebral height, preserving segment motion capability and reducing adjacent joint degeneration.
The traditional artificial intervertebral disc product mainly comprises an upper end plate, a lower end plate and a core, wherein the core and the upper end plate are connected in a ball-and-socket joint mode, and the motion characteristics of human intervertebral discs can be simulated by utilizing the characteristics of the joints. Compared with the human biological intervertebral disc, the human biological intervertebral disc has the motion characteristic of 6 degrees of freedom, and the traditional artificial intervertebral disc product only has partial motion characteristic.
Meanwhile, the upper end plate, the core and the lower end plate of the traditional artificial intervertebral disc are mostly rigid members, and the contact mode of the core and the upper end plate and the contact mode of the core and the lower end plate are mainly rigid contact, so that the stress concentration of the contact surface is easily caused in the reciprocating motion process, and the phenomenon of fatigue fracture is caused, so that the service life of the traditional artificial intervertebral disc is short, and the problems of adverse accidents or secondary operations and the like are caused. Therefore, the demand for designing a bionic intervertebral disc with high fatigue strength is urgent, and the effective prolonging of the service life and the period of the bionic intervertebral disc in vivo is one of the key problems which need to be solved urgently in the development of the traditional artificial intervertebral disc.
Disclosure of Invention
In order to solve the problems of the traditional artificial intervertebral disc products, the invention aims to provide a bionic intervertebral disc capable of resisting fatigue fracture; meanwhile, the human intervertebral disc has the 6-freedom-degree motion characteristic of the human intervertebral disc.
In order to achieve the purpose, the invention takes the human biological intervertebral disc as a blue book and is inspired according to the gradient characteristic of the human biological intervertebral disc.
The biological intervertebral disc of the human body is in the long-term natural selection and evolution process, the tissue structure, material characteristics and performance of the biological intervertebral disc are continuously optimized and improved, the biological intervertebral disc is composed of nucleus pulposus and fibrous ring, the main component of the nucleus pulposus is proteoglycan gel substance with more water content, the biological intervertebral disc is rich in elasticity and has lower rigidity, the main component of the fibrous ring is collagen, the inner layer has lower rigidity according to the hardness classification of the material, and compared with the outer layer of the inner layer, the biological intervertebral disc has higher rigidity. The biological intervertebral disc has gradient characteristics through a special tissue structure and material properties of soft and hard layering, and shows high excellent fatigue fracture resistance in the complex reciprocating motion process of a human body. The biological intervertebral disc realizes the optimized distribution of local mechanical properties by utilizing the gradient characteristics, effectively avoids stress concentration, thereby improving the fatigue fracture resistance and providing a good idea for the design of the bionic intervertebral disc.
Based on the gradient characteristics of the human biological intervertebral disc, the invention adopts the following technical scheme:
a bionic intervertebral disc resisting fatigue fracture is composed of an upper end plate, a lower end plate and a core, wherein one end of the core is fixed to the lower portion of the upper end plate, and the other end of the core is fixed to the upper portion of the lower end plate.
The core comprises a nucleus pulposus and an annulus fibrosus, the nucleus pulposus being composed of a polymeric material; the fiber ring is a functional gradient material and is formed by polymerizing two or more polymer materials with different moduli.
The elastic modulus of the outer surface of the fiber ring is the largest, the elastic modulus of the inner surface of the fiber ring is the smallest, and the elastic modulus of the fiber ring gradually decreases from the outer surface to the inner surface and changes in a continuous gradient manner.
The modulus of elasticity of the inner surface of the annulus is equal to the modulus of elasticity of the outer surface of the nucleus pulposus.
The overall configuration of the upper end plate, the core and the lower end plate is D-shaped.
The upper end plate and the lower end plate are both provided with spikes.
The upper end plate, the lower end plate and the spikes are all made of polymer materials. The polymer material can be selected from ultra-high molecular weight polyethylene or polyether-ether-ketone or thermoplastic polyurethane elastomer rubber.
The upper part of the upper end plate, the lower part of the lower end plate and the outer surface of the sharp thorn are provided with a titanium coating, a hydroxyapatite coating or a calcium carbonate coating, and the coating material can also be other bioactive materials.
Compared with the traditional artificial intervertebral disc product, the invention has the following beneficial effects:
1. through core deformation, the upper end plate and the lower end plate generate relative motion, 6-degree-of-freedom motion characteristics of flexion, extension, lateral bending, rotation, translation and the like of the human intervertebral disc can be simulated, and the problem that the traditional artificial intervertebral disc only has partial motion characteristics is solved.
2. The core has the gradient characteristic similar to that of human body biological intervertebral, the elastic modulus is in continuous gradient change, compared with the traditional artificial intervertebral disc product, the gradient has better fatigue fracture resistance, and the stress concentration can be effectively avoided in the long-term reciprocating motion process and under the same condition, so that the service life of the product is prolonged. Meanwhile, the overall configuration of the upper end plate, the core and the lower end plate is similar to a D shape and is close to the shape of a human biological intervertebral disc, the stress area is increased, stress concentration is avoided, and the anti-fatigue strength of the product can be improved.
3. The spikes help to maintain the stability of the product and the titanium coating helps to be biocompatible with the vertebrae.
Drawings
FIG. 1 is a schematic view of the structure of the present invention.
FIG. 2 is a schematic diagram of the core structure of the present invention.
Fig. 3 is a schematic diagram of a core variation of the present invention.
In the figure: 10-upper end plate; 20-a core; 21-nucleus pulposus; 22-fiber ring; 30-lower end plate; 40-spike.
Detailed Description
As shown in fig. 1, the bionic intervertebral disc resisting fatigue fracture comprises an upper end plate 10, a core 20 and a lower end plate 30, wherein one end of the core 20 is fixed at the lower part of the upper end plate 10, and the other end of the core 20 is fixed at the upper part of the lower end plate 30.
As shown in fig. 2, the core 20 is composed of a nucleus pulposus 21 and an annulus fibrosus 22, and the nucleus pulposus 21 is a thermoplastic polyurethane elastomer rubber material; the fiber ring 22 is a functional gradient material and is formed by polymerizing two or more thermoplastic polyurethane elastomer rubber materials with different moduli, the elastic modulus of the outer surface of the fiber ring 22 is the largest, the elastic modulus of the inner surface of the fiber ring 22 is the smallest, the elastic modulus of the fiber ring 22 gradually decreases from the outer surface to the inner surface and is in continuous gradient change, the elastic modulus of the inner surface of the fiber ring 22 is equal to the elastic modulus of the outer surface of the nucleus pulposus 21, under the action of alternating load, a low elastic modulus area of the core 20 can generate relatively large deformation, the deformation of a high elastic modulus area is small, and in the long-term reciprocating motion process and under the same condition, the load can be absorbed and dispersed to the periphery by using flexibility, so that the.
The upper end plate 10, the core 20 and the lower end plate 30 are D-shaped in overall configuration, the shape of the upper end plate, the core 20 and the lower end plate is close to the shape of a human biological intervertebral disc, the stress area is increased, stress concentration is avoided, and the fatigue resistance of the product is improved.
As shown in figure 3, the upper end plate 10 and the lower end plate 30 can generate relative motion by deforming the core 20, so that the motion characteristics of 6 degrees of freedom such as flexion, extension, lateral bending, rotation, translation and the like of the human intervertebral disc are simulated, and the problem that only part of the motion characteristics of the traditional artificial intervertebral disc are reserved is solved.
The upper end plate 10 and the lower end plate 30 are provided with spikes 40, which is beneficial to maintaining the stability of the product.
The upper end plate 10, the lower end plate 30 and the spikes 40 are made of polymer materials. The polymer material can be selected from ultra-high molecular weight polyethylene or polyether-ether-ketone or thermoplastic polyurethane elastomer rubber.
The upper part of the upper end plate 10, the lower part of the lower end plate 30 and the outer surface of the spine 40 are coated with titanium coating or hydroxyapatite coating or calcium carbonate coating to promote the regeneration and fusion of vertebrae.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110249680.0A CN113017935A (en) | 2021-03-08 | 2021-03-08 | Anti-fatigue fracture bionic intervertebral disc |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110249680.0A CN113017935A (en) | 2021-03-08 | 2021-03-08 | Anti-fatigue fracture bionic intervertebral disc |
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| Publication Number | Publication Date |
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| CN113017935A true CN113017935A (en) | 2021-06-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110249680.0A Pending CN113017935A (en) | 2021-03-08 | 2021-03-08 | Anti-fatigue fracture bionic intervertebral disc |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115969584A (en) * | 2023-01-03 | 2023-04-18 | 吉林大学 | A biomimetic intervertebral disc with mechanical anisotropy |
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|---|---|---|---|---|
| US20050197702A1 (en) * | 2002-08-15 | 2005-09-08 | Coppes Justin K. | Intervertebral disc implant |
| FR2928080A1 (en) * | 2008-02-28 | 2009-09-04 | Warsaw Orthopedic Inc | Intervertebral disk i.e. hernia disk, augmentation implant for vertebral column, has implant body comprising elasticity module gradient such that elasticity module progressively varies from core zone towards wall zone of body |
| CN104208748A (en) * | 2014-07-24 | 2014-12-17 | 苏州大学 | Biodegradable polyurethane having gradient elasticity modulus and tissue engineering fibrous scaffold prepared through same |
| CN106726022A (en) * | 2017-02-22 | 2017-05-31 | 无锡宝莱福医疗器械有限公司 | A kind of artificial intervertebral disk and its forming method without interface friction |
| CN106901876A (en) * | 2017-02-22 | 2017-06-30 | 无锡宝莱福医疗器械有限公司 | A kind of biomimetic type artificial intervertebral disk and its forming method |
-
2021
- 2021-03-08 CN CN202110249680.0A patent/CN113017935A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050197702A1 (en) * | 2002-08-15 | 2005-09-08 | Coppes Justin K. | Intervertebral disc implant |
| FR2928080A1 (en) * | 2008-02-28 | 2009-09-04 | Warsaw Orthopedic Inc | Intervertebral disk i.e. hernia disk, augmentation implant for vertebral column, has implant body comprising elasticity module gradient such that elasticity module progressively varies from core zone towards wall zone of body |
| CN104208748A (en) * | 2014-07-24 | 2014-12-17 | 苏州大学 | Biodegradable polyurethane having gradient elasticity modulus and tissue engineering fibrous scaffold prepared through same |
| CN106726022A (en) * | 2017-02-22 | 2017-05-31 | 无锡宝莱福医疗器械有限公司 | A kind of artificial intervertebral disk and its forming method without interface friction |
| CN106901876A (en) * | 2017-02-22 | 2017-06-30 | 无锡宝莱福医疗器械有限公司 | A kind of biomimetic type artificial intervertebral disk and its forming method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115969584A (en) * | 2023-01-03 | 2023-04-18 | 吉林大学 | A biomimetic intervertebral disc with mechanical anisotropy |
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