CN112998014A - Low-temperature disinfectant composition and preparation method thereof - Google Patents
Low-temperature disinfectant composition and preparation method thereof Download PDFInfo
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- CN112998014A CN112998014A CN202110168342.4A CN202110168342A CN112998014A CN 112998014 A CN112998014 A CN 112998014A CN 202110168342 A CN202110168342 A CN 202110168342A CN 112998014 A CN112998014 A CN 112998014A
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- low
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- ethanol
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
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- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a low-temperature disinfectant composition and a preparation method thereof, and belongs to the field of daily chemicals, wherein the composition comprises propylene glycol, ethanol, benzalkonium chloride and water, and the mass ratio of the propylene glycol to the ethanol to the benzalkonium chloride to the water is (10-40): 10-40: 0.1-0.9: 49.3-69.9; the preparation method comprises the following steps: weighing propylene glycol, ethanol, benzalkonium chloride and water, mixing the above materials, bottling, and packaging to obtain the final product. The disinfectant prepared by the invention still has a disinfection effect under a low-temperature condition.
Description
Technical Field
The invention relates to the field of daily chemicals, in particular to a low-temperature disinfectant composition and a preparation method thereof.
Background
In daily life, disinfectant used by people is mainly concentrated at normal temperature, and rarely used for low-temperature articles (such as a freezing chamber of a household refrigerator), and even cold-chain storage and cold-chain logistics, the disinfectant is rarely used because common disinfectant on the market loses the disinfection effect due to freezing at-18 ℃. Therefore, the development of a product which can be sterilized under low temperature and still be energy-efficient is an important work for dealing with epidemic situations and is of great importance to the health of the whole people.
Disclosure of Invention
The invention aims to provide a low-temperature disinfectant composition and a preparation method thereof, and the prepared disinfectant still has a disinfecting effect under a low-temperature condition.
In order to achieve the purpose, the invention provides the following technical scheme:
the low-temperature disinfectant composition comprises propylene glycol, ethanol, benzalkonium chloride and water, wherein the mass ratio of the propylene glycol to the ethanol to the benzalkonium chloride to the water is (10-40): 10-40: 0.1-0.9: 49.3 to 69.9.
Preferably, the preparation method of the low-temperature disinfectant composition comprises the following steps:
(1) weighing propylene glycol, ethanol, benzalkonium chloride and water for later use;
(2) mixing the above materials, bottling, and packaging to obtain the final product.
Preferably, in the step (1), the total weight of the propylene glycol and the ethanol is not less than 30% of the total weight of the composition.
Compared with the prior art, the invention has the beneficial effects that:
1) the disinfectant prepared by the invention still does not ice at the low temperature of 18 ℃ below zero, while the common disinfectant already freezes at the temperature of 18 ℃ below zero.
2) The disinfectant prepared by the invention still has a disinfection effect at a low temperature of 18 ℃ below zero, while the disinfection effect of the common disinfectant is lost due to icing at the temperature of 18 ℃ below zero.
3) The invention has simple production process, easy operation and no need of complex equipment, and is convenient for rapid production and application in national epidemic prevention.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A preparation method of a low-temperature disinfectant composition comprises the following steps:
(1) weighing 10g of propylene glycol, 40g of ethanol, 0.1g of benzalkonium chloride and 49.9g of water for later use;
(2) uniformly mixing the raw materials to form a low-temperature disinfectant;
(3) and filling and packaging the disinfectant to obtain a finished product.
Example 2
A low-temperature disinfectant composition comprises the following steps:
(1) weighing 20g of propylene glycol, 30g of ethanol, 0.3g of benzalkonium chloride and 49.7g of water for later use;
(2) uniformly mixing the raw materials to form a low-temperature disinfectant;
(3) and filling and packaging the disinfectant to obtain a finished product.
Example 3
A low-temperature disinfectant composition comprises the following steps:
(1) weighing 30g of propylene glycol, 20g of ethanol, 0.5g of benzalkonium chloride and 49.5g of water for later use;
(2) uniformly mixing the raw materials to form a low-temperature disinfectant;
(3) and filling and packaging the disinfectant to obtain a finished product.
Example 4
A low-temperature disinfectant composition comprises the following steps:
(1) weighing 40g of propylene glycol, 10g of ethanol, 0.7g of benzalkonium chloride and 49.3g of water for later use;
(2) uniformly mixing the raw materials to form a low-temperature disinfectant;
(3) and filling and packaging the disinfectant to obtain a finished product.
Example 5
A low-temperature disinfectant composition comprises the following steps:
(1) weighing 10g of propylene glycol, 20g of ethanol, 0.1g of benzalkonium chloride and 69.9g of water for later use;
(2) uniformly mixing the raw materials to form a low-temperature disinfectant;
(3) and filling and packaging the disinfectant to obtain a finished product.
Example 6
A low-temperature disinfectant composition comprises the following steps:
(1) weighing 20g of propylene glycol, 10g of ethanol, 0.9g of benzalkonium chloride and 69.1g of water for later use;
(2) uniformly mixing the raw materials to form a low-temperature disinfectant;
(3) and filling and packaging the disinfectant to obtain a finished product.
Comparative example
The comparative example differs from example 1 only in that the total amount of propylene glycol and ethanol is less than 30% of the total weight of the composition, the amount of propylene glycol is 10g, the amount of ethanol is 10g (10+10 < 30), the amount of benzalkonium chloride is 0.1, and less than 100g of water is used to make up the disinfectant composition.
Effect of low temperature test
The test method comprises the following steps: disinfectant solutions were prepared according to examples 1 to 6 and comparative examples, and then the disinfectant solutions were placed in refrigerators set at-18 ℃ respectively, and stored for 24 hours and then observed whether or not they were frozen.
The test results are shown in the following table:
TABLE 1 results of low temperature test of examples 1-6 and comparative examples
The low-temperature test results show that the examples 1, 2, 3, 4, 5 and 6 are all superior to the comparative examples, which shows that the disinfection solution can not freeze at the low temperature of-18 ℃ only after the compounding amount of the propylene glycol and the ethanol reaches the specified amount, namely the total dosage of the propylene glycol and the ethanol is not less than 30 percent of the total weight of the composition.
Effect of Sterilization test
The test method comprises the following steps: the killing test of staphylococcus aureus was carried out according to the method of the "Disinfection technical Specification" (2002 edition), the disinfection solutions prepared in examples 1-6 and comparative example were respectively put into a refrigerator set at-18 ℃ for 24 hours, the disinfection solution was used for the killing test for 24 hours, the test temperature of the killing test of staphylococcus aureus was-18 ℃ and the action time was 30 minutes, and the growth condition of microorganisms on the cell was observed.
The test results are shown in the following table:
TABLE 2 examples 1-6 and comparative examples Low temperature Sterilization test results
| Sample name | Observing growth condition of microorganism on the bacterial sheet |
| Example 1 | No bacterial plaque (i.e. 0 cfu/tablet) |
| Example 2 | No bacterial plaque (i.e. 0 cfu/tablet) |
| Example 3 | No bacterial plaque (i.e. 0 cfu/tablet) |
| Example 4 | No bacterial plaque (i.e. 0 cfu/tablet) |
| Example 5 | No bacterial plaque (i.e. 0 cfu/tablet) |
| Example 6 | No bacterial plaque (i.e. 0 cfu/tablet) |
| Comparative example | ＞1*106cfu/tablet |
The sterilization test results show that the examples 1, 2, 3, 4, 5 and 6 are all superior to the comparative examples, which shows that the disinfection solution can be effectively sterilized only by not freezing the disinfection solution at the low temperature of-18 ℃ and not freezing after the compound amount of the propylene glycol and the ethanol reaches the specified amount, namely the total dosage of the propylene glycol and the ethanol is not less than 30% of the total weight of the composition, and the comparative examples also have the bactericide benzalkonium chloride, but the disinfection effect can not be recovered due to the freezing.
Therefore, the low-temperature type disinfectant composition can still not freeze at the low temperature of 18 ℃ below zero, and still has a disinfection effect at the low temperature of 18 ℃ below zero, while common disinfectant (such as 84 disinfectant, benzalkonium chloride disinfectant and the like) loses the disinfection effect because of freezing at the low temperature of 18 ℃ below zero, and the low-temperature type disinfectant composition can effectively disinfect in the low-temperature conditions of a freezing chamber, a cold chain storage, cold chain logistics and the like of a common household refrigerator.
The foregoing is merely exemplary and illustrative of the present invention, and various modifications, additions and substitutions may be made by those skilled in the art to the specific embodiments described without departing from the scope of the invention as defined in the following claims.
Claims (3)
1. A low-temperature disinfectant composition is characterized in that: the composition comprises propylene glycol, ethanol, benzalkonium chloride and water, wherein the mass ratio of the propylene glycol to the ethanol to the benzalkonium chloride to the water is 10-40: 10-40: 0.1-0.9: 49.3 to 69.9.
2. The method of claim 1, comprising the steps of:
(1) weighing propylene glycol, ethanol, benzalkonium chloride and water for later use;
(2) mixing the above materials, bottling, and packaging to obtain the final product.
3. The method of claim 2, wherein the method further comprises the steps of: in the step (1), the total weight of the propylene glycol and the ethanol is not less than 30% of the total weight of the composition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110168342.4A CN112998014A (en) | 2021-02-07 | 2021-02-07 | Low-temperature disinfectant composition and preparation method thereof |
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| CN202110168342.4A CN112998014A (en) | 2021-02-07 | 2021-02-07 | Low-temperature disinfectant composition and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100374099C (en) * | 1998-01-20 | 2008-03-12 | 伊西康公司 | Antimicrobial composition |
| CN109228537A (en) * | 2018-10-13 | 2019-01-18 | 安徽紫金鹏印务有限公司 | A kind of waterproof label moisturizing formula and technique |
| US20190209494A1 (en) * | 2018-01-10 | 2019-07-11 | Insys Development Company, Inc. | Methods of stabilizing epinephrine |
| CN111840182A (en) * | 2020-07-27 | 2020-10-30 | 支允前 | Multifunctional traditional Chinese medicine antibacterial sanitary wet tissue and preparation method thereof |
-
2021
- 2021-02-07 CN CN202110168342.4A patent/CN112998014A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100374099C (en) * | 1998-01-20 | 2008-03-12 | 伊西康公司 | Antimicrobial composition |
| US20190209494A1 (en) * | 2018-01-10 | 2019-07-11 | Insys Development Company, Inc. | Methods of stabilizing epinephrine |
| CN109228537A (en) * | 2018-10-13 | 2019-01-18 | 安徽紫金鹏印务有限公司 | A kind of waterproof label moisturizing formula and technique |
| CN111840182A (en) * | 2020-07-27 | 2020-10-30 | 支允前 | Multifunctional traditional Chinese medicine antibacterial sanitary wet tissue and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| HOLGER LESSMANN等: "Skin-sensitizing and irritant properties of propylene glycol", 《CONTACT DERMATITIS》 * |
| MI YOUNG KANG等: "Efficacy test of commercially available disinfectants against foot-and-mouth virus under subzero temperature using anti-freezing diluents", 《JAPANESE JOURNAL OF VETERINARY RESEARCH》 * |
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