CN112977908B - Filling and plugging machine and filling method thereof - Google Patents
Filling and plugging machine and filling method thereof Download PDFInfo
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- CN112977908B CN112977908B CN202110230313.6A CN202110230313A CN112977908B CN 112977908 B CN112977908 B CN 112977908B CN 202110230313 A CN202110230313 A CN 202110230313A CN 112977908 B CN112977908 B CN 112977908B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/18—Controlling escape of air from containers or receptacles during filling
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/26—Methods or devices for controlling the quantity of the material fed or filled
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B7/00—Closing containers or receptacles after filling
- B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
- B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
- B65B7/2821—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers applying plugs or threadless stoppers
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Basic Packing Technique (AREA)
Abstract
The invention provides a filling and plugging machine and a filling method thereof, relating to the technical field of medical equipment and comprising a liquid separator; the liquid feeding pipeline is provided with a plurality of liquid separating outlets, each liquid separating outlet is communicated with one liquid feeding pipeline; each liquid conveying pipeline comprises a first liquid inlet pipe, at least one peristaltic pump liquid conveying pipe and a second liquid inlet pipe; the head end of the first liquid inlet pipe is communicated with a liquid separation outlet, the tail end of the first liquid inlet pipe is communicated with the inlet of at least one peristaltic pump liquid conveying pipe, and the outlet of the peristaltic pump liquid conveying pipe is communicated with the head end of the second liquid inlet pipe; the number of the perfusion needles is multiple, and each perfusion needle is communicated with the tail end of the second liquid inlet pipe in one liquid running pipeline, so that an independent perfusion passage is formed between the corresponding liquid separating outlet of the liquid separator and the corresponding perfusion needle. In the technical scheme, the problem of perfusion precision reduction caused by non-uniform speed of two stages can be avoided, and the perfusion precision is improved.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a filling and plugging machine and a filling method thereof.
Background
The filling and plugging machine is filling and sealing equipment of sterile preparations, and can generally adapt to the small-capacity subpackaging requirements of 0.5-3 ml honeycomb pre-filling and sealing syringes and snap-type bottles. The filling production of a plurality of filling needles can be realized at the same time, and the filling and sealing speed per hour is over ten thousand. However, when the filling and plugging machine in the prior art fills the liquid medicine, the stability and accuracy of the filling are still poor, and the filling requirement of high speed and high accuracy cannot be met.
Disclosure of Invention
The invention aims to provide a filling and plugging machine and a filling method thereof, which aim to solve the technical problem that the filling stability and accuracy of the filling and plugging machine in the prior art are poor.
The invention provides a filling and plugging machine, which comprises:
a liquid separator;
the liquid distributor is provided with a plurality of matched liquid separation outlets, and each liquid separation outlet is communicated with one liquid conveying pipeline; each liquid conveying pipeline comprises a first liquid inlet pipe, at least one peristaltic pump liquid conveying pipe and a second liquid inlet pipe; the head end of the first liquid inlet pipe is communicated with one liquid separating outlet, the tail end of the first liquid inlet pipe is communicated with the inlet of at least one peristaltic pump liquid conveying pipe, and the outlet of the peristaltic pump liquid conveying pipe is communicated with the head end of the second liquid inlet pipe;
the number of the perfusion needles is multiple, and each perfusion needle is communicated with the tail end of the second liquid inlet pipe in one liquid running pipeline, so that an independent perfusion passage is formed between the corresponding liquid separating outlet of the liquid distributor and the corresponding perfusion needle.
Furthermore, each liquid conveying pipeline is provided with a first liquid inlet pipe, two peristaltic pump liquid conveying pipes and a second liquid inlet pipe; the head end of the first liquid inlet pipe is communicated with the liquid separating outlet, the tail end of the first liquid inlet pipe is communicated with the inlets of the two peristaltic pump liquid conveying pipes in parallel, and the outlets of the two peristaltic pump liquid conveying pipes are communicated with the head end of the second liquid inlet pipe in parallel.
Furthermore, the aperture of the first liquid inlet pipe is larger than that of the second liquid inlet pipe.
Further, the aperture of the first liquid inlet pipe is between 8mm and 12 mm; and/or the aperture of the second liquid inlet pipe is between 2mm and 4mm.
Further, the filling and plugging machine further comprises:
and the liquid inlet quantity controller is connected with the liquid separator and is used for controlling the real-time liquid inlet quantity of the liquid separator.
Furthermore, the material of first feed liquor pipe peristaltic pump fluid delivery pipe and/or second feed liquor pipe is the silica gel material, just first feed liquor pipe peristaltic pump fluid delivery pipe and/or second feed liquor pipe soak through the sodium hydroxide solution of 3% concentration to carry out sterilization treatment for 30 minutes at least under 121 ℃ high temperature.
Further, the inner diameter of the peristaltic pump liquid conveying pipe is between 1.59mm and 2.38mm, the outer diameter of the peristaltic pump liquid conveying pipe is between 4.77mm and 5.56mm, and the length of the peristaltic pump liquid conveying pipe is between 150mm and 160 mm.
Further, the aperture of the perfusion needle head is between 1.5mm and 3.0 mm.
The application also provides a method for filling by adopting the filling and plugging machine, which comprises the following steps:
according to the peristaltic pump rotational speed regulation of peristaltic pump delivery tube the feed liquor volume of knockout makes the feed liquor volume with the infusion pressure and the rate matching of peristaltic pump delivery tube, and then control liquid medicine in the knockout pass through first feed liquor pipe the peristaltic pump delivery tube with second feed liquor pipe flow direction fill the syringe needle.
Further, the filling needle is controlled to enter the bottle to be filled to fill the bottle neck position of the bottle, so that the liquid medicine output by the filling needle is enabled to remove air at the bottle neck position, then the height of the filling needle in the bottle to be filled is adjusted, and the filling of the rest positions of the bottle to be filled is completed.
In the above-mentioned technical scheme, when the liquid medicine that the peristaltic pump transfusion tube exported the knockout drives and flows, the pumping power of this peristaltic pump can be applyed between first feed liquor pipe and second feed liquor pipe, the intermediate position of liquid medicine transportation process is transferred to through the pumping power with the peristaltic pump, can improve the stability that the liquid medicine was carried, guarantee that the liquid medicine enters into the stage of first feed liquor pipe from the knockout, and the liquid medicine enters into the stage of filling the syringe needle from second feed liquor pipe, the flow rate etc. of liquid medicine all keep relative balance, just so can guarantee that the liquid medicine fills with stable state at the in-process that fills, avoid the inhomogeneous problem that leads to filling accurate decline of rate in two stages, and then improve accurate filling nature.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic view of a liquid feeding pipeline connection of a filling and plugging machine according to an embodiment of the present invention;
fig. 2 is a schematic view of an overall connection structure of a filling and plugging machine according to an embodiment of the present invention.
Reference numerals are as follows:
1. a liquid separator; 2. a liquid feeding pipeline; 3. filling a needle head;
21. a first liquid inlet pipe; 22. a peristaltic pump liquid conveying pipe; 23. a second liquid inlet pipe.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it is to be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in a specific case to those of ordinary skill in the art.
As shown in fig. 1 and fig. 2, the filling and plugging machine provided in this embodiment includes a dispenser 1. In addition, the filling and plugging machine further comprises a plurality of liquid feeding pipelines 2, the liquid distributor 1 is provided with a plurality of matched liquid distribution outlets, and each liquid distribution outlet is communicated with one liquid feeding pipeline 2; each liquid conveying pipeline 2 comprises a first liquid inlet pipe 21, at least one peristaltic pump liquid conveying pipe 22 and a second liquid inlet pipe 23; the head end of first feed liquor pipe 21 with one divide liquid outlet intercommunication, the tail end of first feed liquor pipe 21 with at least one peristaltic pump liquid conveying pipe 22's entry intercommunication, peristaltic pump liquid conveying pipe 22's export with the head end of second feed liquor pipe 23 communicates. Simultaneously, this filling machine of pluging still includes filling syringe needle 3, the quantity of filling syringe needle 3 is a plurality of, every filling syringe needle 3 all with one walk in the liquid pipeline 2 the tail end intercommunication of second feed liquor pipe 23 to at the corresponding branch liquid of knockout 1 export to the correspondence form solitary filling path between filling syringe needle 3.
Thus, by means of the connecting arrangement between the dispenser 1, the feed line 2 and the filling needle 3, a filling path can be formed from the dispenser 1 through the feed line 2 to the filling needle 3. It should be noted that the liquid feeding pipeline 2 in the filling and plugging machine adopts a two-section liquid inlet pipe structure, that is, a first liquid inlet pipe 21 directly connected to the liquid separating outlet of the liquid separator 1, and a second liquid inlet pipe 23 directly connected to the filling needle 3, wherein at least one peristaltic pump liquid conveying pipe 22 is arranged between the first liquid inlet pipe 21 and the second liquid inlet pipe 23, and the peristaltic pump liquid conveying pipe 22 is utilized to communicate the first liquid inlet pipe 21 and the second liquid inlet pipe 23, thereby forming a filling path from the liquid separator 1 to the filling needle 3 through the first liquid inlet pipe 21, the peristaltic pump liquid conveying pipe 22 and the second liquid inlet pipe 23.
In the structural design, after the liquid conveying pipeline 2 forms two sections of liquid inlet pipe structures through the first liquid inlet pipe 21 and the second liquid inlet pipe 23, and the two sections of liquid inlet pipe structures are communicated through the peristaltic pump liquid conveying pipe 22, when the peristaltic pump liquid conveying pipe 22 drives and flows the liquid medicine output by the dispenser 1, the pumping force of the peristaltic pump can be applied between the first liquid inlet pipe 21 and the second liquid inlet pipe 23, namely the pumping force of the peristaltic pump can be applied to the middle position where the liquid medicine flows, the stability of liquid medicine conveying can be improved by transferring the pumping force of the peristaltic pump to the middle position of the liquid medicine conveying process, the stage that the liquid medicine enters the first liquid inlet pipe 21 from the liquid distributor 1 is ensured, and the stage that the liquid medicine enters the filling needle 3 from the second liquid inlet pipe 23 are ensured, the flowing rate and the like of the liquid medicine are kept relatively balanced, so that the liquid medicine can be filled in a stable state in the filling process, the problem that the filling precision is reduced due to the uneven speed of the two stages is avoided, and the filling precision is improved. The peristaltic pump liquid delivery tube 22 may be a separate structure that the peristaltic pump is assembled on the liquid delivery tube, or the peristaltic pump may be integrated on the liquid delivery tube, which is not limited herein.
In a specific embodiment, the specific structure of the infusion lines 2 may be defined, for example, each infusion line 2 is provided with a first inlet pipe 21, two peristaltic pump infusion pipes 22 and a second inlet pipe 23; the head end of the first liquid inlet pipe 21 is communicated with the liquid separating outlet, the tail end of the first liquid inlet pipe 21 is communicated with the inlets of the peristaltic pump liquid inlet pipes 22 in parallel, and the outlets of the peristaltic pump liquid inlet pipes 22 are communicated with the head end of the second liquid inlet pipe 23 in parallel. At this moment, the liquid separator 1 can distribute the liquid medicine to each liquid conveying pipeline 2, then the liquid medicine of each liquid conveying pipeline 2 flows to the two peristaltic pump liquid conveying pipes 22 through the first liquid inlet pipe 21, at this moment, the two peristaltic pump liquid conveying pipes 22 are assembled in parallel, the liquid medicine flowing out of the first liquid inlet pipe 21 can be synchronously pumped, the peristaltic pumps in the two peristaltic pump liquid conveying pipes 22 can form a double-pumping effect, because the two peristaltic pumps can form a mutually-coordinated pumping effect when pumping, for example, when the pumping capacity of one peristaltic pump is unstable, the other peristaltic pump can timely supplement pumping, the liquid medicine between the first liquid inlet pipe 21 and the second liquid inlet pipe 23 is pumped in balance through the mutual coordination of the two peristaltic pumps, and through the relatively-coordinated pumping force, the liquid medicine can be effectively formed into a more stable pumping effect between the first liquid inlet pipe 21 and the second liquid inlet pipe 23.
In another specific embodiment, the aperture of the first liquid inlet pipe 21 is larger than the aperture of the second liquid inlet pipe 23, at this time, a relatively large flow rate can be formed in the first liquid inlet pipe 21 with a large aperture, and after the liquid enters the second liquid inlet pipe 23, since the aperture of the second liquid inlet pipe 23 is reduced, a buffering effect can be formed, thereby ensuring the stability of the liquid outlet amount. Wherein the aperture of the first liquid inlet pipe 21 is between 8mm and 12 mm; and/or the aperture of the second liquid inlet pipe 23 is between 2mm and 4mm. For example, the first liquid inlet pipe 21 may have a bore diameter of 8mm, 9mm, 10mm, 11mm, 12mm, and the second liquid inlet pipe 23 may have a bore diameter of 2mm, 3mm, 4mm. The technical personnel in the field can set up the aperture size of first feed liquor pipe 21 and second feed liquor pipe 23 as required to form the cooperation between first feed liquor pipe 21 and second feed liquor pipe 23, realize carrying the buffering of liquid medicine, improve the stability that the liquid medicine was carried.
In another specific embodiment, the filling and stoppering machine further comprises a liquid inlet controller, and the liquid inlet controller is connected with the liquid distributor 1 and used for controlling the real-time liquid inlet amount of the liquid distributor 1. Because, the feed liquor volume of knockout 1 all has certain influence to play liquid pressure and speed, if the knockout 1 does not have relative control to the feed liquor volume, goes out liquid pressure and will increase, mismatching with the peristaltic pump rotational speed during the filling leads to the filling precision not high. Therefore, the limiting limit value of the target filling quantity and the maximum filling quantity of the liquid separator 1 can be adjusted through the liquid inlet quantity controller, the diameter of the liquid outlet is changed to control the liquid outlet quantity, and meanwhile, the filling precision is improved by matching with the rotating speed of the filling peristaltic pump. The liquid inlet controller may adopt various valve structures or other components with liquid flow control, which is not limited herein.
In another specific embodiment, the first liquid inlet pipe 21, the peristaltic pump liquid outlet pipe 22 and/or the second liquid inlet pipe 23 are made of silica gel, and the first liquid inlet pipe 21, the peristaltic pump liquid outlet pipe 22 and/or the second liquid inlet pipe 23 are soaked in a 3% sodium hydroxide solution, and are sterilized at 121 ℃ for at least 30 minutes. Because the quality and the flow rate of the liquid medicine can also be influenced by the material and the size of the silicone tube, when the first liquid inlet tube 21, the peristaltic pump liquid delivery tube 22 and the second liquid inlet tube 23 in the liquid delivery pipeline 2 are assembled, the silicone tube can be soaked in a NaoH solution with the concentration of 3% in advance, and sterilization treatment is carried out for at least 30 minutes at the high temperature of 121 ℃, so that the silicone tube material can be tested and screened in the aspects of alkalinity resistance, high temperature resistance, wear resistance and the like in advance, and the filling precision and the product quality are prevented from being influenced.
Furthermore, the wall thickness, the inner diameter and the length of the silicone tube are important factors influencing the transmission of the liquid medicine, and further the filling precision is influenced. For example, the thickness of the tube wall determines the degree of spring-back of the silicone tube after compression. The rebound force is too big after the silicone tube compression is performed to the wall thickness, and the pipeline joint is easy to cause the tube collapse, resulting in liquid leakage. Thin tube wall is not wear-resistant, and the resilience is small, which is not favorable for controlling the flow rate of the liquid medicine. Meanwhile, the inner diameter of the silicone tube is large, the flow of liquid medicine in unit time is large, and the filling precision is not easy to control. The inner diameter of the silicone tube is small, the flow of the liquid medicine in unit time is small, and the filling can not be completed within the specified filling time.
Therefore, for the reasons mentioned above, after a lot of experiments, the inner diameter of the peristaltic pump fluid tube 22 can be controlled to be between 1.59mm and 2.38mm, the outer diameter of the peristaltic pump fluid tube 22 can be controlled to be between 4.77mm and 5.56mm, and the length of the peristaltic pump fluid tube 22 can be controlled to be between 150mm and 160 mm. For example, the inner diameter of the peristaltic pump tubing 22 may be 1.59mm or 2.38mm, the outer diameter of the peristaltic pump tubing 22 may be 4.77mm or 5.56mm, and the length of the peristaltic pump tubing 22 may be 155mm. For other parameters, those skilled in the art can set the parameters according to the requirements, and the setting is not limited herein.
Simultaneously, the aperture of filling syringe needle also can the direct influence filling volume's precision, though the filling is fast when using the thick filling syringe needle production in aperture, but the control stability of filling volume precision is relatively poor, so can adjust the aperture of filling syringe needle this moment, according to product filling volume and package material difference, adjusts different specification filling syringe needles. For example, a 1.5mm bore filling needle may be provided for a 3ml pre-filled cartridge, and a 2.0mm or 3.0mm bore filling needle may be provided for a 1-3ml format pre-filled needle package. Through being equipped with suitable filling syringe needle to different filling demands, just can effectual assurance filling liquid medicine play liquid volume velocity of flow stability, the filling precision is high.
The application also provides a method for filling by adopting the filling and plugging machine, which comprises the following steps: according to the peristaltic pump rotational speed of peristaltic pump delivery tube 22 adjusts the feed liquor volume of knockout 1, make the feed liquor volume with the infusion pressure and the rate matching of peristaltic pump delivery tube 22, and then control liquid medicine in the knockout 1 passes through first feed liquor pipe 21 peristaltic pump delivery tube 22 with second feed liquor pipe 23 flow direction fill syringe needle 3. Because, the feed liquor volume of knockout 1 all has certain influence to going out liquid pressure and speed, if knockout 1 does not have relative control to the feed liquor volume, goes out liquid pressure and will increase, mismatch with the peristaltic pump rotational speed when causing the filling, leads to the filling precision not high. Therefore, the limiting limit value of the target filling quantity and the maximum filling quantity of the liquid separator 1 can be adjusted through the liquid inlet quantity controller, the diameter of the liquid outlet is changed to control the liquid outlet quantity, and meanwhile, the filling precision is improved by matching with the rotating speed of the filling peristaltic pump.
The matching between the liquid inlet quantity of the peristaltic pump and the liquid distributor 1 can be adjusted according to actual conditions, so that the filling rate and other factors are controlled within a preset range, and the liquid inlet quantity is adjusted in real time in the filling process so as to match the infusion pressure and the infusion rate of the peristaltic pump in real time. Meanwhile, an independent controller can be arranged and connected between the liquid separator 1 and the liquid conveying pipe 22 of the peristaltic pump, so that the liquid conveying pressure and the speed of the peristaltic pump can be detected in real time, feedback is formed, the liquid inlet amount of the liquid separator 1 can be adjusted in real time, and the liquid conveying pressure and the speed of the peristaltic pump can be matched in time. The liquid inlet amount of the liquid separator 1 can be controlled by various external valve structures, or can be controlled by other components with liquid flow control, which is not limited herein.
Further, the filling needle 3 is controlled to enter the bottle to be filled to fill the bottle neck position of the bottle, so that the liquid medicine output by the filling needle 3 is discharged from the bottle neck position, and then the height of the filling needle 3 in the bottle to be filled is adjusted to complete the filling of the rest positions of the bottle to be filled. Because the filling curve is one of the important factors influencing the filling precision, under the condition that the properties of the product such as density and viscosity need to be accurately calculated, the waiting position and the starting extending position of the filling needle, the moving speed of the filling needle during filling and the stopping position of the filling needle after filling are comprehensively considered, the whole filling curve needs to be accurately controlled by parameters, the filling curve is ensured to be smooth at a constant speed in the whole filling process, waterline filling is formed, the curve is ensured not to be broken, the filling needle cannot be soaked in liquid medicine, and the filling needle head cannot hang liquid and cannot be sticky.
Therefore, the filling can be performed in two steps, in one embodiment, for example, in the filling process of the pre-filled cartridge bottle, the filling needle 3 is controlled to extend downward to the lowest position of the cartridge bottle and keep a certain distance from the bottle cap in the first step of filling, and the bottle neck position is filled first, so that the liquid medicine is discharged from the air at the bottle neck position. And in the second step of filling, the filling needle head 3 can be controlled to be lifted upwards and start to extend for the second time to complete filling of the rest part, and meanwhile, the rising speed of the filling needle head 3 and the distance between the filling needle head and the liquid level are controlled to ensure the filling precision. The air evacuation operation is a direct way of removing bubbles in the sealed silica gel pipeline, and is a precondition for ensuring the filling precision. The proper emptying time and the appropriate emptying liquid medicine amount can fully exhaust the air in the pipeline, and ensure that the filling process continuously meets the filling precision.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (9)
1. A filling and corking machine, comprising:
a liquid separator;
the liquid distributor is provided with a plurality of matched liquid separation outlets, and each liquid separation outlet is communicated with one liquid conveying pipeline; each liquid conveying pipeline comprises a first liquid inlet pipe, at least one peristaltic pump liquid conveying pipe and a second liquid inlet pipe; the head end of the first liquid inlet pipe is communicated with one liquid separating outlet, the tail end of the first liquid inlet pipe is communicated with the inlet of at least one peristaltic pump liquid conveying pipe, and the outlet of the peristaltic pump liquid conveying pipe is communicated with the head end of the second liquid inlet pipe;
a plurality of perfusion needles are arranged, and each perfusion needle is communicated with the tail end of the second liquid inlet pipe in one liquid running pipeline, so that an independent perfusion passage is formed between the corresponding liquid separating outlet of the liquid separator and the corresponding perfusion needle;
the liquid inlet quantity controller is connected with the liquid separator and used for controlling the real-time liquid inlet quantity of the liquid separator, adjusting the limiting limit value of the target filling quantity and the maximum filling quantity of the liquid separator through the liquid inlet quantity controller and changing the diameter of the liquid outlet to control the liquid outlet quantity; and
an independent controller is arranged, the controller is connected between the liquid distributor and the liquid conveying pipe of the peristaltic pump, the liquid conveying pressure and the speed of the peristaltic pump are detected in real time, feedback is formed, the liquid inlet quantity of the liquid distributor is adjusted in real time, and the liquid conveying pressure and the speed of the peristaltic pump are matched in time.
2. The filling and stoppering machine according to claim 1, wherein each of the liquid feeding lines is provided with a first liquid inlet pipe, two peristaltic pump liquid conveying pipes and a second liquid inlet pipe; the head end of the first liquid inlet pipe is communicated with the liquid separating outlet, the tail end of the first liquid inlet pipe is communicated with the inlets of the two peristaltic pump liquid conveying pipes in parallel, and the outlets of the two peristaltic pump liquid conveying pipes are communicated with the head end of the second liquid inlet pipe in parallel.
3. The filling and stoppering machine of claim 1, wherein the aperture of the first liquid inlet pipe is larger than the aperture of the second liquid inlet pipe.
4. The filling and stoppering machine of claim 3, wherein the aperture of the first liquid inlet pipe is between 8mm and 12 mm; and/or the aperture of the second liquid inlet pipe is between 2mm and 4mm.
5. The filling and stoppering machine according to any one of claims 1 to 4, wherein the first liquid inlet pipe, the peristaltic pump liquid delivery pipe and/or the second liquid inlet pipe are made of silica gel, and the first liquid inlet pipe, the peristaltic pump liquid delivery pipe and/or the second liquid inlet pipe are soaked in sodium hydroxide solution with concentration of 3%, and are sterilized at high temperature of 121 ℃ for at least 30 minutes.
6. A filling and stoppering machine according to any of claims 1-4, wherein the inner diameter of the peristaltic pump tubing is between 1.59mm-2.38mm, the outer diameter of the peristaltic pump tubing is between 4.77mm-5.56mm, and the length of the peristaltic pump tubing is between 150mm-160 mm.
7. A filling and stoppering machine according to any of claims 1-4, wherein the bore diameter of the filling needle is between 1.5mm-3.0 mm.
8. A method of filling using a filling and stoppering machine according to any of claims 1 to 7, comprising the steps of:
according to the peristaltic pump rotational speed of peristaltic pump delivery tube is adjusted the feed liquor volume of knockout, makes the feed liquor volume with the infusion pressure and the rate matching of peristaltic pump delivery tube, and then control liquid medicine in the knockout process first feed liquor pipe peristaltic pump delivery tube with second feed liquor pipe flow direction fill the syringe needle.
9. The filling method according to claim 8, wherein the filling needle is controlled to enter the bottle to be filled to fill the bottle at the bottleneck position, so that the liquid medicine output by the filling needle is exhausted from the bottleneck position, and then the height of the filling needle in the bottle to be filled is adjusted to complete the filling of the rest positions of the bottle to be filled.
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| CN202110230313.6A CN112977908B (en) | 2021-03-02 | 2021-03-02 | Filling and plugging machine and filling method thereof |
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