CN112933407B - Electrode structure, electrode patch, and cell division suppression device - Google Patents
Electrode structure, electrode patch, and cell division suppression device Download PDFInfo
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- 230000032823 cell division Effects 0.000 title claims abstract description 37
- 230000001629 suppression Effects 0.000 title claims abstract description 14
- 230000005684 electric field Effects 0.000 claims abstract description 73
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- 239000002131 composite material Substances 0.000 claims description 3
- 230000022534 cell killing Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 18
- 230000005764 inhibitory process Effects 0.000 abstract description 18
- 230000009286 beneficial effect Effects 0.000 abstract description 11
- 210000004027 cell Anatomy 0.000 description 10
- 230000002829 reductive effect Effects 0.000 description 10
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- 238000010586 diagram Methods 0.000 description 6
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- 238000004220 aggregation Methods 0.000 description 3
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- 238000005265 energy consumption Methods 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 2
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- 241000196324 Embryophyta Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000004243 Tubulin Human genes 0.000 description 1
- 108090000704 Tubulin Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
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- 210000000349 chromosome Anatomy 0.000 description 1
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- 230000007246 mechanism Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
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Abstract
The embodiment of the application provides an electrode structure, an electrode patch and a cell division suppression device. The electrode structure includes: at least two stages of electrode bodies, at least one stage of electrode body in the at least two stages of electrode bodies being used for being electrically connected with a power supply; and one end of any one electric connection structure is connected with one electrode main body in the two adjacent electrode main bodies, and the other end of any electric connection structure is connected with the other electrode main body in the two adjacent electrode main bodies. The embodiment of the application adopts a multi-stage electrode structure of at least two stages of electrode main bodies, which is beneficial to increasing the output electric field area and improving the inhibition efficiency of cell division; the adjacent two-stage electrode main bodies are directly and electrically connected through the electric connection structure, so that the current distribution in each electrode is more balanced, the electric field intensity output by each electrode is more balanced, the comfort level of the body feeling of a patient is improved, and the inhibition effect of the electric field on cell division is improved.
Description
Technical Field
The application relates to the technical field of medical equipment, in particular to an electrode structure, an electrode patch and a cell division suppression device.
Background
In the electric field therapy, an electric field is used for destroying mitosis to prevent cancer cells from completing rapid division, and an electrode patch is attached to a focus area, or tubulin is influenced to be clustered through the middle stage of the electric field to prevent spindle bodies in the pathological cells from forming, so that chromosomes cannot be separated normally; or at the end of division of the diseased cells, the electric field pushes the charges toward the neck of the dividing cells, destroying the diseased cell structure. The end result of both mechanisms of action is to inhibit normal division of diseased cells.
The electrode patch is an important implementation structure of electric field therapy, and the self structure of the electrode patch directly influences the performance of an output electric field. However, the existing electrode patch has the defects of limited electric field area, uneven electric field intensity distribution, high energy consumption and the like.
Disclosure of Invention
The application provides an electrode structure, an electrode patch and a cell division suppression device aiming at the defects of the prior art, which are used for solving the technical problems of limited electric field area output by the electrode patch, uneven electric field intensity distribution, high energy consumption and the like in the prior art.
In a first aspect, an embodiment of the present application provides an electrode structure, including:
At least two stages of electrode bodies, at least one stage of electrode body in the at least two stages of electrode bodies being used for being electrically connected with a power supply;
and one end of any one electric connection structure is connected with one electrode main body in the two adjacent electrode main bodies, and the other end of any electric connection structure is connected with the other electrode main body in the two adjacent electrode main bodies.
Optionally, the electrode body is used to generate an electric field that inhibits cell division or kills cells.
Optionally, in the adjacent two-stage electrode bodies, the upper-stage electrode body is provided with at least one lower-stage electrode body, and each lower-stage electrode body surrounds the periphery of the upper-stage electrode body.
Optionally, the electrode body comprises at least one of the following features:
The ratio of the dimensions of the upper stage electrode body to the lower stage electrode body is not less than 1:1 and not more than 4:1;
the ratio of the distance between the upper electrode body and the lower electrode body to the maximum outer diameter of the upper electrode body is not less than 1:2 and not more than 4:1;
the ratio of the number of the upper stage electrode bodies to the number of the lower stage electrode bodies is not less than 1:10 and not more than 1:1.
Optionally, the electrode structure further comprises: at least one barbed structure; one end of any barbed structure is connected to one electrode body.
Optionally, the electrode body includes at least one of a polygonal electrode body, an electrode body having an outer contour curve, and an irregularly shaped electrode body.
Optionally, at least one of the corners of the polygonal electrode body is connected to one end of the electrical connection structure.
Optionally, the electrode structure further comprises: at least one barbed structure; at least one of the corners of the polygonal electrode body, which are not connected with the electrical connection structure, is connected with one end of the corresponding barbed structure.
Optionally, the polygonal electrode body is a regular polygonal electrode body.
In a second aspect, an embodiment of the present application provides an electrode patch, including: any one of the electrode structures as provided in the first aspect.
Optionally, the electrode patch further comprises an insulating layer and a skin-friendly layer which are stacked; the electrode structure is positioned between the insulating layer and the skin-friendly layer, and the electrode main body of the electrode structure is used for being electrically connected with a power supply; the side of the skin-friendly layer, which is far away from the insulating layer, is used for being attached to the skin surface.
Optionally, a side of the insulating layer, which is close to the skin-friendly layer, is provided with a containing groove; the electrode structure is inlaid in the accommodating groove.
In a third aspect, embodiments of the present application provide a cell division suppression device comprising: a power supply, and any one of the electrode patches as provided in the second aspect;
The electrode body of the electrode structure in the electrode patch is electrically connected with a power supply.
Optionally, the power source is an ac power source; or, the power supply is a pulse power supply.
The technical scheme provided by the embodiment of the application has the beneficial technical effects that at least:
1. the multi-stage electrode structure of at least two stages of electrode main bodies is beneficial to increasing the output electric field area, so that the inhibition efficiency of cell division is improved.
2. The adjacent two-stage electrode main bodies can be directly and electrically connected through the electric connection structure, so that current distribution in each electrode is more balanced, electric field intensity output by each electrode is more balanced, on one hand, current stimulation or local heat effect can be greatly reduced, the comfort level of a patient is improved, on the other hand, the inhibition effect of an electric field on cell division can be improved, on the other hand, energy loss can be reduced, and energy utilization efficiency is improved.
Additional aspects and advantages of the application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the application.
Drawings
The foregoing and/or additional aspects and advantages of the application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings, in which:
fig. 1 is a schematic structural diagram of a first embodiment of an electrode structure according to an embodiment of the present application;
fig. 2 is a schematic structural diagram of a second embodiment of an electrode structure according to an embodiment of the present application;
fig. 3 is a schematic structural diagram of a third embodiment of an electrode structure according to an embodiment of the present application;
fig. 4 is a schematic structural diagram of an electrode patch according to an embodiment of the present application;
FIG. 5 is a schematic view of the structure of the A-A plane in FIG. 4;
Fig. 6 is a schematic diagram of a cell division suppression device according to an embodiment of the present application.
In the figure:
10-electrode structure;
11-a first stage electrode body; 12-a secondary electrode body; 13-a tertiary electrode body; 14-a fourth stage electrode body; 15-an electrical connection structure; 16-barbed structure;
20-electrode patches; 21-an insulating layer; 21 a-a receiving groove; 22-a skin-friendly layer; 23-conducting wires;
30-cell division suppression device; 31-power supply.
Detailed Description
The present application is described in detail below, examples of embodiments of the application are illustrated in the accompanying drawings, wherein the same or similar reference numerals refer to the same or similar components or components having the same or similar functions throughout. Further, if detailed description of the known technology is not necessary for the illustrated features of the present application, it will be omitted. The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the application.
It will be understood by those skilled in the art that all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs unless defined otherwise. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless expressly stated otherwise, as understood by those skilled in the art. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. It should be understood that the term "and/or" as used herein includes all or any element and all combination of one or more of the associated listed items.
The inventor of the present application conducted studies and found that in the existing electrode patches, only one electrode is usually disposed for each electrode patch, which results in a very limited electric field area output by the electrode patch, and severely limits the inhibition efficiency of cell division. In some electrode patches configured with a plurality of electrodes, the electrodes are independently arranged, that is, each electrode has an independent wire to realize power supply, and the electrodes are not electrically connected, so that the conditions of uneven current distribution in each electrode and uneven electric field intensity output by each electrode are very easy to occur. The unbalanced current distribution can cause certain current stimulation or local thermal effect, so that patients feel uncomfortable; uneven electric field distribution will affect the effect of the electric field on inhibiting cell division, resulting in incomplete inhibition of cell division. In addition, the independent layout of the electrodes also causes an increase in energy consumption during the shunt or partial pressure process.
The application provides an electrode structure, an electrode patch and a cell division suppression device, and aims to solve the technical problems in the prior art.
The following describes the technical scheme of the present application and how the technical scheme of the present application solves the above technical problems in detail with specific embodiments.
It should be noted that, in order to facilitate the reader to understand the technical solution proposed by the present application more easily, the electrode structures shown in the following embodiments are all described by taking four-stage structures (including the first-stage electrode body 11, the second-stage electrode body 12, the third-stage electrode body 13 and the fourth-stage electrode body 14) as examples, but the technical solution proposed by the present application is not limited to the case of only four-stage structures, and is certainly applicable to electrode structures having two stages, three stages, five stages, six stages and more.
An embodiment of the present application provides an electrode structure 10, and a schematic structural diagram of the electrode structure 10 is shown in fig. 1, including but not limited to: at least two electrode bodies, and at least one electrical connection 15.
At least one of the at least two electrode bodies is for electrical connection with a power source 31.
One end of any one electric connection structure 15 is connected with one electrode body of the two adjacent electrode bodies, and the other end of any one electric connection structure 15 is connected with the other electrode body of the two adjacent electrode bodies.
In fig. 1, n2, and n3 are optional values: natural numbers of 0,1,2,3 … …, etc.
Optionally, the electrode body is used to generate an electric field that inhibits cell division or kills cells.
In this embodiment, the multi-stage electrode structure 10 with at least two stages of electrode bodies is adopted, which is favorable for increasing the output electric field area, and further improving the inhibition efficiency of cell division.
Moreover, the adjacent two-stage electrode main bodies can be directly and electrically connected through the electric connection structure 15, so that the current distribution in each electrode is more balanced, the electric field intensity output by each electrode is more balanced, on one hand, the current stimulation or local heat effect can be greatly reduced, the comfort level of the body feeling of a patient is improved, on the other hand, the inhibition effect of the electric field on cell division can be improved, on the other hand, the energy loss can be reduced, and the energy utilization efficiency is improved.
For example, as shown in fig. 2 or 3, the electrode structure 10 may be a four-stage structure including a first-stage electrode body 11, a second-stage electrode body 12, a third-stage electrode body 13, and a fourth-stage electrode body 14. The first-stage electrode body 11 and the second-stage electrode body 12 are directly and electrically connected through an electrical connection structure 15, the second-stage electrode body 12 and the third-stage electrode body 13 are directly and electrically connected through an electrical connection structure 15, and the third-stage electrode body 13 and the fourth-stage electrode body 14 are directly and electrically connected through an electrical connection structure 15.
Alternatively, the electrode bodies of each stage and each electrical connection structure 15 may be made of the same conductive material.
In some possible embodiments, in the adjacent two-stage electrode bodies, the upper-stage electrode body is provided with at least one lower-stage electrode body, and each lower-stage electrode body surrounds the upper-stage electrode body.
In this embodiment, a layout structure in which the electrode body of the next stage surrounds the electrode body of the previous stage is adopted, which is beneficial to balance the current distribution between the electrode bodies of the next stage. And, each next-stage electrode main body is connected with the previous-stage electrode main body through the corresponding electric connection structure 15, so that the current distribution in each electrode can be more balanced, and the electric field intensity output by each electrode can be more balanced.
For example, as shown in fig. 2 or 3, one first-stage electrode body 11 has a surrounding layout corresponding to a plurality of second-stage electrode bodies 12, one second-stage electrode body 12 has a surrounding layout corresponding to a plurality of third-stage electrode bodies 13, and one third-stage electrode body 13 has a surrounding layout corresponding to a plurality of fourth-stage electrode bodies 14.
It can be understood that the greater the number of the next electrode bodies in the two adjacent electrode bodies, the more advantageous the output electric field area is increased, thereby improving the inhibition efficiency of cell division.
Alternatively, the distances between the respective lower electrode bodies and the upper electrode bodies are equal.
Alternatively, the distance between each of the lower electrode bodies and the upper electrode body is not equal. For example: the connecting line of the center point of each next-stage electrode main body is a closed ring formed by wavy lines.
Optionally, the electrode main body of the next stage and the electrode main body of the previous stage are mutually in fractal structures, that is, each stage of electrode main body can adopt a fractal structure, and each electrode main body of the next stage is in a shape which is formed by shrinking the electrode main body of the previous stage according to a certain proportion. Of course, when the number of electrode bodies is small or the pitch between the electrode bodies is sufficient, each lower electrode body may be a shape obtained by enlarging the upper electrode body in a predetermined ratio. The fractal structure is beneficial to more balance of current distribution in each electrode and more balance of electric field intensity output by each electrode.
For example, as shown in fig. 3, the second-stage electrode body 12 is a scaled-down shape of the first-stage electrode body 11, the third-stage electrode body 13 is a scaled-down shape of the second-stage electrode body 12, and the fourth-stage electrode body 14 is a scaled-down shape of the third-stage electrode body 13.
Optionally, each next-stage electrode body is rotationally symmetric about a corresponding previous-stage electrode body. The adoption of the rotationally symmetrical layout structure is beneficial to more balance of the electric field intensity output by the whole electrode structure 10, can greatly reduce current stimulation or local heat effect, improves the comfort level of the body feeling of patients, can improve the inhibition effect of the electric field on cell division, can reduce energy loss and improves the energy utilization efficiency.
For example, as shown in fig. 3, each of the second-stage electrode bodies 12 surrounding one of the first-stage electrode bodies 11 is rotationally symmetrical with respect to the first-stage electrode body 11; each of the third-stage electrode bodies 13 surrounding one of the second-stage electrode bodies 12 is rotationally symmetrical with respect to the second-stage electrode body 12; each of the fourth-stage electrode bodies 14, which surrounds one of the third-stage electrode bodies 13, is rotationally symmetrical with respect to the third-stage electrode body 13.
Based on any of the above embodiments, the electrode body may include, but is not limited to, at least one of the following features:
Optionally, the ratio of the dimensions of the upper stage electrode body to the lower stage electrode body is not less than 1:1 and not greater than 3:1.
Optionally, the ratio of the distance between the upper electrode body and the lower electrode body to the maximum outer diameter of the upper electrode body is not less than 1:2 and not more than 3:1.
Optionally, the ratio of the number of upper stage electrode bodies to the number of lower stage electrode bodies is not less than 1:10 and not more than 1:1.
The inventors of the present application contemplate that the region of the electric field output by the electrode structure 10 has a relationship with the point on the electrode structure 10 where the electric field can be output. To this end, the application provides one possible implementation of the electrode structure 10 as follows:
As shown in fig. 2 or 3, the electrode structure 10 of the embodiment of the present application further includes, but is not limited to: at least one barbed structure 16. One end of either barbed structure 16 is connected to one electrode body. The barbed structure can be similar to a barbed structure on a plant stem leaf and a fruit shell, is of an elongated shape and has a certain tip.
In this embodiment, under energized conditions, the tips of each barbed structure 16 may facilitate the formation of charge accumulation, thereby forming a sub-electric field. The sub-electric field can be used to form a complementary electric field to the main electric field formed at the electrode bodies of each stage, i.e., to perfect the electric field region output by the electrode structure 10 as a whole, thereby improving the inhibition efficiency of cell division.
It will be appreciated that the barbed structure 16 may be laid out according to the position between each lower electrode body and the corresponding upper electrode body, i.e. for the weaker electric field region in the main electric field formed by each electrode body, so that the sub-electric field generated by the barbed structure 16 may play a role in supplementing the electric field strength.
In addition, the sub-electric field at the tip of the barbed structure 16 and the main electric field at the electrode body together can form a composite electric field, which is beneficial to improving the inhibiting effect of cell division.
Alternatively, the barbed structure 16 may be formed of the same conductive material as the electrode bodies of each stage.
Alternatively, the barbed structure 16 may be made of the same conductive material as each of the electrical connection structures 15.
Alternatively, the barbed structure 16 may be the same or similar in size or shape as the electrical connection structure 15. For example, the barbed structure 16 may be straight, arcuate, wavy, lightning-shaped, or the like.
The inventors of the present application considered that the electrode shape of the conventional electrode patch 20 is mostly circular or convex, and only one electric field can be formed at each electrode, which hinders the increase of the electric field area or the individualization requirement. To this end, the application provides one possible implementation of the electrode structure 10 as follows:
The electrode body of the embodiment of the application comprises at least one of a polygonal electrode body, an electrode body with a curve outline and an electrode body with an irregular shape, but is not limited to the polygonal electrode body.
Alternatively, the shape of the polygonal electrode body may be triangular, rectangular, pentagonal, hexagonal, etc., and so on. The electrode body with the outer contour line being a curve can be a closed graph with the contour line being an arc line or a wavy line, and can be a circle or an ellipse.
In some possible embodiments, when the electrode body adopts a polygonal electrode body structure, corners of the polygonal electrode body can also form a certain tip structure, so that under the condition of power on, the corners of the polygonal electrode body can also be favorable for forming charge accumulation, and further forming a sub-electric field. The sub-electric field can also be used for forming a complementary electric field of the main electric field formed at the electrode bodies of each stage, namely, the electric field region output by the electrode structure 10 as a whole can be perfected, and further, the inhibition efficiency of cell division is improved.
In addition, the sub-electric field at the corners of the polygonal electrode body and the main electric field at the electrode body can form a composite electric field, which is beneficial to improving the inhibiting effect of cell division.
In some possible embodiments, at least one of the corners of the polygonal electrode body is connected to one end of the electrical connection structure 15.
In this embodiment, one end of the electrical connection structure 15 is connected to the corners of the polygonal electrode body, so that the characteristic that charges are easy to gather to the corners of the polygonal electrode body can be fully utilized, the conductivity between two adjacent electrode bodies is improved, i.e. the energy loss can be reduced, and the energy utilization efficiency is improved.
It can be understood that the corners of the polygonal electrode body not connected to the electrical connection structure 15 can still form a certain sub-electric field, and the complementary electric field of the main electric field formed at each stage of electrode body, so as to perfect the electric field area output by the electrode structure 10 as a whole, and further improve the inhibition efficiency of cell division.
In some possible embodiments, the electrode structure 10 further includes, but is not limited to: at least one barbed structure 16. At least one of the corners of the polygonal electrode body, which are not connected to the electrical connection structure 15, is connected to one end of the corresponding barbed structure 16.
In this embodiment, one end of the barbed structure 16 is connected to the corners of the polygonal electrode body, so that the characteristic that charges are easy to collect toward the corners of the polygonal electrode body can be fully utilized, the charge collection effect of the tip of the barbed structure 16 is improved, and the sub-electric field generated at the tip of the barbed structure 16 is enhanced.
It can be understood that, in the polygonal electrode body, corners not connected to the electrical connection structure 15 and the barbed structure 16 can still form a certain sub-electric field, and a complementary electric field to the main electric field formed at each stage of electrode body, so as to perfect the electric field area output by the electrode structure 10 as a whole, and further improve the inhibition efficiency of cell division.
Optionally, the polygonal electrode body is a regular polygonal electrode body. The charge aggregation degree of each corner is favorable to be balanced, namely the intensity of the sub-electric field formed at the corner of the polygonal electrode main body is more balanced.
Based on the same inventive concept, an embodiment of the present application provides an electrode patch 20, as shown in fig. 4, the electrode patch 20 includes, but is not limited to: any of the electrode structures 10 provided in the foregoing embodiments.
In this embodiment, since the electrode patch 20 adopts any one of the electrode structures 10 provided in the foregoing embodiments, the principle and technical effects thereof are shown in the foregoing embodiments, and are not repeated herein.
Alternatively, the electrode patches 20 may be used in pairs. For example, in use, any pair of electrode patches 20 are attached to the skin on both sides of the lesion tissue such that each pair of electrode patches 20 is opposite or substantially opposite, and the electric fields generated by the electrode structures 10 within each pair of electrode patches 20 act together on the lesion tissue cells, thereby inhibiting the normal division of the lesion cells.
In some possible embodiments, the electrode patch 20 further includes an insulating layer 21 and a skin friendly layer 22 that are stacked.
The electrode structure 10 is located between the insulating layer 21 and the skin friendly layer 22, and the electrode body of the electrode structure 10 is used for electrical connection with a power source 31.
The side of the skin friendly layer 22 remote from the insulating layer 21 is intended to be attached to the skin surface.
In this embodiment, the skin-friendly layer 22 may facilitate attachment of the electrode patch 20 to the skin surface corresponding to the focal tissue. The insulating layer 21 can prevent unnecessary electric leakage during operation of the electrode patch 20, improve safety during operation, and reduce power consumption.
Alternatively, the skin-friendly layer 22 may be a silicone material.
Alternatively, as shown in fig. 5, a side of the insulating layer 21 close to the skin-friendly layer 22 has a receiving groove 21a, and the electrode structure 10 is embedded in the receiving groove 21 a. This facilitates complete adhesion of the insulating layer 21 to the skin-friendly layer 22, and improves structural stability of the electrode patch 20.
Optionally, as shown in fig. 4, the electrode patch 20 further comprises a wire 23. One end of the wire 23 extends into the accommodating groove 21a from between the insulating layer 21 and the skin-friendly layer 22, and is connected with any one of the electrode bodies (for example, with the first-stage electrode body 11) of the electrode structure 10, and the other end of the wire 23 is used for being electrically connected with a power supply, thereby realizing the power supply for the electrode structure 10 of the electrode patch 20.
Based on the same inventive concept, embodiments of the present application provide a cell division suppression device 30, as shown in fig. 6, the cell division suppression device 30 includes, but is not limited to: a power supply 31, and any of the electrode patches 20 provided in the previous embodiments.
The electrode body of the electrode structure 10 in the electrode patch 20 is electrically connected to a power source 31.
In this embodiment, the power supply 31 may provide electrical energy to the electrode structures 10 in the electrode patch 20 so that the electrode structures 10 are capable of generating a desired electric field.
In this embodiment, since the cell division suppression device 30 adopts any one of the electrode patches 20 provided in the foregoing embodiments, the principle and technical effects thereof are shown in the foregoing embodiments, and are not described herein.
Alternatively, the power source 31 is an ac power source 31. The ac power supply 31 provides ac current that enables the electrode structure 10 in the electrode patch 20 to generate a desired ac electric field.
Alternatively, the power source 31 is a pulsed power source 31. The pulsed current provided by the pulsed power supply 31 enables the electrode structure 10 in the electrode patch 20 to generate the desired pulsed electric field.
By applying the embodiment of the application, at least the following beneficial effects can be realized:
1. the multi-stage electrode structure 10 with at least two stages of electrode bodies is beneficial to increasing the output electric field area, so that the inhibition efficiency of cell division is improved.
2. The adjacent two-stage electrode main bodies can be directly and electrically connected through the electric connection structure 15, so that current distribution in each electrode is more balanced, electric field intensity output by each electrode is more balanced, on one hand, current stimulation or local heat effect can be greatly reduced, comfort level of a patient is improved, on the other hand, inhibition effect of an electric field on cell division can be improved, on the other hand, energy loss can be reduced, and energy utilization efficiency is improved.
3. The layout structure that the lower electrode main body surrounds the periphery of the upper electrode main body is adopted, so that the current distribution among the lower electrode main bodies is balanced. And, each next-stage electrode main body is connected with the previous-stage electrode main body through the corresponding electric connection structure 15, so that the current distribution in each electrode can be more balanced, and the electric field intensity output by each electrode can be more balanced.
4. The electrode main bodies of all levels can adopt fractal structures, which is beneficial to more balance of current distribution in each electrode and more balance of electric field intensity output by each electrode.
5. The lower electrode bodies are rotationally symmetrical with respect to the corresponding upper electrode body, so that the electric field intensity output by the whole electrode structure 10 is more balanced, current stimulation or local thermal effect can be greatly reduced, the comfort level of a patient is improved, the inhibition effect of an electric field on cell division can be improved, energy loss can be reduced, and the energy utilization efficiency is improved.
6. The tips of each barbed structure 16 may facilitate the formation of charge collection, which in turn, creates a sub-electric field. The sub-electric field can be used to form a complementary electric field to the main electric field formed at the electrode bodies of each stage, i.e., to perfect the electric field region output by the electrode structure 10 as a whole, thereby improving the inhibition efficiency of cell division.
7. When the electrode main body adopts a polygonal electrode main body structure, the corners of the polygonal electrode main body can also form a certain tip structure, so that under the condition of electrifying, the corners of the polygonal electrode main body can be favorable for forming charge aggregation, and then a sub-electric field is formed. The sub-electric field can also be used for forming a complementary electric field of the main electric field formed at the electrode bodies of each stage, namely, the electric field region output by the electrode structure 10 as a whole can be perfected, and further, the inhibition efficiency of cell division is improved.
8. One end of the electric connection structure 15 is connected with the corners of the polygonal electrode main body, so that the characteristic that charges are easy to gather towards the corners of the polygonal electrode main body can be fully utilized, the electric conductivity between the adjacent two-stage electrode main bodies is improved, the energy loss can be reduced, and the energy utilization efficiency is improved.
9. One end of the barbed structure 16 is connected with the corners of the polygonal electrode body, so that the characteristic that charges are easy to gather towards the corners of the polygonal electrode body can be fully utilized, the charge gathering effect of the tip of the barbed structure 16 is improved, and the sub-electric field generated at the tip of the barbed structure 16 is enhanced.
10. The polygonal electrode body is a regular polygonal electrode body, which is favorable for balancing the charge aggregation degree of each corner, namely, the intensity of the sub-electric field formed at the corner of the polygonal electrode body is more balanced.
It will be appreciated by those skilled in the art that in the description of the present application, it is to be understood that the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, merely to facilitate description of the present application and simplify the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present application.
The terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present application, unless otherwise indicated, the meaning of "a plurality" is two or more.
In the description of the present application, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present application will be understood in specific cases by those of ordinary skill in the art.
In the description of the present specification, a particular feature, structure, material, or characteristic may be combined in any suitable manner in one or more embodiments or examples.
The foregoing is only a partial embodiment of the present application, and it should be noted that it will be apparent to those skilled in the art that modifications and adaptations can be made without departing from the principles of the present application, and such modifications and adaptations are intended to be comprehended within the scope of the present application.
Claims (8)
1. An electrode structure, comprising:
At least two stages of electrode bodies, at least one stage of the electrode bodies being used for being electrically connected with a power supply; in the adjacent two stages of electrode bodies, at least one electrode body of the next stage is arranged on the electrode body of the previous stage, and each electrode body of the next stage surrounds the periphery of the electrode body of the previous stage; the electrode main body of the next stage and the electrode main body of the previous stage are of fractal structures, and/or each electrode main body of the next stage is rotationally symmetrical relative to the corresponding electrode main body of the previous stage; the electrode body includes a polygonal electrode body; the electrode body is used for forming a main electric field for inhibiting cell division or killing cells;
One end of any one electric connection structure is connected with one electrode main body of two adjacent stages of electrode main bodies, and the other end of any electric connection structure is connected with the other electrode main body of the two adjacent stages of electrode main bodies; at least one of the corners of the polygonal electrode body is connected with one end of the electrical connection structure;
At least one barbed structure, each corner of the polygonal electrode body not connected with the electrical connection structure, at least one corner being connected with one end of the corresponding barbed structure; the barbed structure comprises at least one of straight bars, arcs, waves and lightning shapes, wherein the tip end of the barbed structure is used for forming a sub-electric field, and the sub-electric field and the main electric field jointly form a composite electric field.
2. The electrode structure of claim 1, wherein the electrode body comprises at least one of the following features:
The ratio of the dimensions of the electrode body of the upper stage to the electrode body of the lower stage is not less than 1:1 and not more than 4:1;
the ratio of the distance between the electrode main body at the upper stage and the electrode main body at the lower stage to the maximum outer diameter of the electrode main body at the upper stage is not less than 1:2 and not more than 4:1;
the ratio of the number of the electrode bodies of the upper stage to the number of the electrode bodies of the lower stage is not less than 1:10 and not more than 1:1.
3. The electrode structure of claim 1, wherein the polygonal electrode body is a regular polygonal electrode body.
4. An electrode patch, comprising: an electrode structure as claimed in any one of claims 1 to 3.
5. The electrode patch of claim 4, further comprising an insulating layer and a skin friendly layer disposed in a stack;
The electrode structure is positioned between the insulating layer and the skin-friendly layer, and an electrode main body of the electrode structure is used for being electrically connected with a power supply;
The side of the skin-friendly layer, which is far away from the insulating layer, is used for being attached to the skin surface.
6. The electrode patch of claim 5, wherein a side of the insulating layer adjacent to the skin-friendly layer has a receiving groove;
the electrode structure is inlaid in the accommodating groove.
7. A cell division suppression device, comprising: a power supply, and an electrode patch as claimed in any one of claims 4 to 6;
The electrode body of the electrode structure in the electrode patch is electrically connected with the power supply.
8. The cell division suppression device of claim 7, wherein the power source is an ac power source; or, the power supply is a pulse power supply.
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| WO2008034100A2 (en) * | 2006-09-14 | 2008-03-20 | Lazure Technologies, Llc | Ablation probe with deployable electrodes |
| CN211132716U (en) * | 2019-04-18 | 2020-07-31 | 马冲 | Tumor therapeutic apparatus |
| CN111481823A (en) * | 2020-05-07 | 2020-08-04 | 河北普尼医疗科技有限公司 | Device for treating multiple organ tumors based on electric field |
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