CN112931854B

CN112931854B - Hair growth and digestion promoting composition

Info

Publication number: CN112931854B
Application number: CN202110155100.1A
Authority: CN
Inventors: 易斌; 岳玉荣; 韩雅慧
Original assignee: Jiangxi Jianchangbang Dietotherapy Technology Co ltd
Current assignee: Jiangxi Jianchangbang Dietotherapy Technology Co ltd
Priority date: 2021-02-04
Filing date: 2021-02-04
Publication date: 2023-09-12
Anticipated expiration: 2041-02-04
Also published as: CN112931854A

Abstract

The invention relates to the technical field of health products, in particular to a hair growth promoting and digestion promoting composition. The composition is prepared by compounding 30-40 parts of red dates, 35-60 parts of beef bones, 8-35 parts of kelp, 5-30 parts of ginger, 5-10 parts of cinnamon and 0.1-1 part of folic acid compounds, and is suitable for pregnant women, has a good digestion-promoting effect, can ensure the absorption of nutrition under the condition of less food for the pregnant women, and further ensures the nutrition supply of hair.

Description

Hair growth and digestion promoting composition

Technical Field

The invention belongs to the technical field of health products, and particularly relates to a hair growth promoting and digestion promoting composition.

Background

Alopecia is pathological alopecia and physiological alopecia, and hair falling off by 100 normal people every day is normal phenomenon, which belongs to physiological alopecia. Pathologic alopecia is excessive hair loss. Alopecia refers to abnormal or excessive hair loss, the main symptoms of which are greasy hair or scorched hair, lack of gloss, difficulty in fixing pale yellow scales, or flying off grey scales. Modern medicine considers that alopecia has a very close relationship with genetic factors, hormone levels and nutritional factors. Alopecia mainly comprises the following types according to the reasons: (1) seborrheic alopecia: currently Western medicine treats male seborrheic alopecia because male alopecia is associated with in vivo dihydrotestosterone concentration. It has been shown that female seborrheic alopecia is associated with elevated levels of scalp testosterone, and not elevated levels of dihydrotestosterone, indicating that female seborrheic alopecia should be dominated by anti-androgenic medications. (2) Pathological alopecia: mainly because viruses, bacteria and high heat damage hair mother cells, the hair follicle is prevented from normal division, and hair follicle is in shock state to cause alopecia, such as acute infectious disease, long-term administration of certain medicine, etc. (3) Chemical hair loss: damage to scalp tissue, hair follicle cells by harmful chemicals results in hair loss. (4) Physical hair loss: air pollutants block hair follicles, and alopecia caused by harmful radiation, etc. (5) Nutritional hair loss: malnutrition caused by digestive absorption dysfunction leads to alopecia. (6) Obesity alopecia: a large amount of saturated fatty acids are metabolized in the body to produce waste products, and clogging of hair follicles leads to alopecia. (7) Hereditary hair loss: alopecia is also inherited, and is typically inherited in dominant form in men and in negative form in women.

During pregnancy of pregnant women, due to unbalanced nutrition, high psychological pressure, and the need of simultaneously nourishing the fetus with physical nutrient substances, alopecia symptoms may be generated during pregnancy of pregnant women, and products such as medicines or medicated diet for treating alopecia on the market may affect the fetus in consideration of incomplete physiological development of the fetus.

Chinese patent application CN111558015A discloses a traditional Chinese medicine composition for treating alopecia, which comprises 18-22 parts by weight of lucid ganoderma, 4-6 parts by weight of prepared fleece-flower root, 18-22 parts by weight of medlar, 18-22 parts by weight of mulberry, 6-10 parts by weight of ginseng, 18-22 parts by weight of astragalus root, 6-8 parts by weight of epimedium herb, 8-12 parts by weight of pseudo-ginseng, 8-12 parts by weight of rhizoma polygonati, 6-8 parts by weight of angelica and 3-5 parts by weight of fructus amomi. The effective rate of the composition for treating 480 patients suffering from seborrheic alopecia is 91.2%, the curative effect of 210 patients suffering from alopecia areata is 89.3%, and the effect is remarkable, but the medicine application principle of the composition clearly indicates that the pregnant woman is forbidden. Presumably, the adverse effects of ganoderma lucidum, ginseng, wolfberry fruit, angelica and the like on the fetus cannot be eliminated due to the too strong medicinal properties.

Chinese patent application CN105412758A discloses a traditional Chinese medicine composition for promoting hair loss recovery, comprising the following components in parts by weight: comprises 20-25 parts of gentian, 15-20 parts of radix rehmanniae, 15-20 parts of galangal, 10-15 parts of trollius chinensis, 10-15 parts of sandalwood, 10-15 parts of donkey-hide gelatin, 5-10 parts of dayflower, 4-8 parts of loquat leaf and 3-6 parts of ginkgo leaf. The cure rate of 100 patients is 72%, the effective rate is 98%, and the failure rate is 2%. Similarly, the wording "the pregnant woman should use with cautions" is marked in the notice of the product.

Therefore, it is desirable to develop products for pregnant women to treat or prevent hair loss.

Disclosure of Invention

The invention aims at overcoming the defects of the prior art and providing a composition for promoting hair growth and helping digestion.

The object of the invention is achieved by the following scheme.

The composition for promoting hair growth and aiding digestion comprises the following raw materials in parts by weight:

30-40 parts of red dates, 35-60 parts of beef bones, 8-35 parts of kelp, 5-30 parts of ginger, 5-10 parts of cinnamon and 0.1-1 part of folic acid compounds.

Further, the composition comprises the following preparation raw materials in parts by weight:

30 parts of red date, 50 parts of beef bones, 20 parts of kelp, 18 parts of ginger, 8 parts of cinnamon and 0.5 part of folic acid compounds.

Further, the folic acid compounds are one or more of folic acid, leucovorin, L-methyl folic acid, folic acid medicinal salt, folic acid or folic acid medicinal salt active metabolite and substances capable of being metabolized and/or generating folic acid in vivo.

Further, the folic acid compound is at least one selected from folic acid, folic acid pharmaceutically acceptable salts and folic acid methyl ester.

Further, the compositions of the present invention further comprise at least one pharmaceutically acceptable excipient; the excipient is a diluent, binder, disintegrant, lubricant, colorant, flavoring agent, pH adjustor, buffering agent, homogenizing agent, preservative, anti-adhesive agent, glidant, acidulant, sweetener, or any combination thereof.

Such excipients include, but are not limited to, mannitol, sodium metabisulfite, sodium bisulphite, sodium thiosulfate, cysteine hydrochloride, methionine, disodium C, EDTA, calcium sodium EDTA, monovalent alkali metal carbonates, acetates, phosphates or aqueous solutions thereof, amino acids, sodium chloride, potassium chloride, sodium lactate, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivatives, cellulose and derivatives thereof, alginates, gelatin, polyvinylpyrrolidone, glycerol, ground temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactants, polyethylene glycols, cyclodextrins, beta-cyclodextrin, phospholipid materials, kaolin, talc and calcium stearate, which can be selected by those skilled in the art according to the actual application of the present invention.

The invention also provides a preparation method of the composition, which comprises the following steps,

s1: respectively crushing the red dates, the beef bones and the kelp in parts by weight, adding the crushed red dates, the beef bones and the kelp into water, then adding hydrochloric acid to adjust the pH to be acidic, heating and refluxing for extraction, and carrying out solid-liquid separation after the extraction is finished to obtain an extract A;

s2: concentrating the extract A under reduced pressure to obtain a part of solvent, adding sodium hydroxide to adjust pH to alkaline, and stirring to obtain extract B;

s3: concentrating the extract B to obtain a part of solvent, desalting with a chromatographic column with C18 as filler and water as eluent, collecting the fraction with water and ethanol mixture as eluent, concentrating, and drying to obtain extract;

s4: drying rhizoma Zingiberis recens and cortex Cinnamomi, pulverizing, mixing with the extract and folic acid compounds, and grinding into powder.

Further, in S1, the crushing is carried out until the crushing is carried out to 40-60 meshes, the water consumption is 6-8 times of the total amount of the red dates, the beef bones and the kelp according to the weight fraction, the concentration of the hydrochloric acid is 1-3M, the pH is regulated to 4-5, and the reflux time is 4-6h.

The solid-liquid separation described in S1 may be performed by conventional means in the art, such as filtration, centrifugation, and the like.

Further, in S1, the reflux system is monitored for pH at any time, and when pH > 5, hydrochloric acid is added to make ph=4-5.

Further, in S2, the concentration is 1/4-1/3 of the volume of the extracting solution A, the concentration of sodium hydroxide is 1-3M, and the pH is adjusted to 7-8.

Further, in S3, the concentration is carried out to 1/4-1/3 of the volume of the extracting solution, the filler is used for 1/4-1/3 of the volume of the extracting solution B, 1-2 column volumes of water are used for desalting, and the volume ratio of water to ethanol in the water and ethanol mixed solution is 1:1-2, and the volume of the collected fraction column is 3-6 column volumes.

Further, in S4, the crushing is carried out to 10-20 meshes, the powder is 40-60 meshes, and the drying is carried out to a dry matter content of less than 5%.

The invention has the advantages that:

1. the health care product of the invention can play roles of preventing alopecia, moisturizing, strengthening hair, and the like, has no side effect, and can be widely applied to women after pregnancy.

2. When the bovine bone contains a large amount of amino acids and the kelp and the red dates are simultaneously extracted, the complex of the amino acids and trace metals can be obtained, so that the obtained complex of the metal ions is contained in the composition, the absorption of the amino acids and the metal ions after the product enters a human body is enhanced, the amino acid supplementing effect of the product is enhanced, the blood circulation and the nutrition supply of capillaries at the scalp can be promoted, and the alopecia preventing and treating effect is improved.

3. The composition provided by the invention has the digestion-aiding effect, ginger and cinnamon are matched, and other findings have a certain synergistic effect in digestion-aiding, so that the composition helps digestion under the condition of less food for pregnant women, and the utilization rate of food nutrition is improved.

4. The invention utilizes reasonable collocation of raw materials and is matched with a proper extraction compounding method, thereby obtaining better effects in promoting nutrition absorption and hair growth, simultaneously, each component is safe and has no side effect, and the invention is suitable for pregnant women to use as hair growth products.

Detailed Description

The materials used in the invention are all commercial sources and meet the relevant national standard or industry standard.

Example 1

30 parts of red date, 60 parts of beef bone, 15 parts of kelp, 15 parts of ginger, 7 parts of cinnamon and 0.5 part of folic acid.

Hair growth and digestion promoting composition

S1: respectively crushing the red dates, the beef bones and the kelp by weight parts to 40 meshes, adding 840 parts of water, then adding 3M hydrochloric acid to regulate pH=4, heating and refluxing for extraction, monitoring the pH of a system in a refluxing process, adding hydrochloric acid to ensure that the pH=4 when the pH of the system is more than 5, extracting for 4 hours, and filtering after the extraction is completed to obtain an extract A;

s2: concentrating the extract A to 1/3 under reduced pressure, adding 3M sodium hydroxide to adjust pH to 8, and stirring for 2 hr to obtain extract B;

s3: concentrating the extract B to 1/4, using a chromatographic column with C18 as a filler, wherein the filler is 1/3 of the volume of the extract B, desalting by using 1 column of water, and then: ethanol = 1:1 elution 2 volumes, water: eluting with ethanol=1:2 for 2 volumes, collecting eluate, concentrating, and drying to obtain extract;

s4: drying rhizoma Zingiberis recens and cortex Cinnamomi until water content is less than 5%, pulverizing to 10 mesh, mixing with extract and folic acid, and grinding into 50 mesh powder.

Example 2

40 parts of red date, 40 parts of beef bone, 35 parts of kelp, 5 parts of ginger, 10 parts of cinnamon and 0.1 part of folic acid.

Hair growth and digestion promoting composition

S1: respectively crushing the red dates, the beef bones and the kelp by weight parts to 60 meshes, adding 690 parts of water, then adding 1M hydrochloric acid to adjust the pH to be=5, heating and refluxing for extraction, monitoring the pH of a system in a refluxing process, adding hydrochloric acid to enable the pH to be=5 when the pH of the system is more than 5, extracting for 6 hours, and filtering after the extraction is completed to obtain an extract A;

s2: concentrating the extract A to 1/4 under reduced pressure, adding 2M sodium hydroxide to adjust pH to 7, and stirring for 4 hr to obtain extract B;

s3: concentrating the extract B to 1/3, desalting by using a chromatographic column with C18 as a filler, wherein the filler amount is 1/4 of the volume of the extract B, and then water by using 2 column volumes: ethanol = 1:1 elution 3 volumes, water: eluting with ethanol=1:2 for 3 volumes, collecting eluate, concentrating, and drying to obtain extract;

s4: drying rhizoma Zingiberis recens and cortex Cinnamomi until the water content is less than 3%, pulverizing to 20 mesh, mixing with the extract and folic acid, and grinding into 60 mesh powder to obtain the composition.

Example 3

35 parts of red date, 35 parts of beef bone, 10 parts of kelp, 30 parts of ginger, 10 parts of cinnamon and 1 part of folic acid.

Hair growth and digestion promoting composition

S1: respectively crushing the red dates, the beef bones and the kelp by weight parts to 50 meshes, adding 560 parts of water, then adding 2M hydrochloric acid to regulate the pH value to be 4.5, heating and refluxing for extraction, monitoring the pH value of a system in a refluxing process, adding hydrochloric acid to ensure the pH value to be 4.5 when the pH value of the system is more than 5, extracting for 5 hours, and filtering after the extraction is finished to obtain an extract A;

s2: concentrating the extract A to 1/4 under reduced pressure, adding 1M sodium hydroxide to adjust pH=7.5, and stirring for 2 hr to obtain extract B;

s3: concentrating the extract B to 1/4, desalting by using a chromatographic column with C18 as a filler, wherein the filler content is 1/3 of the volume of the extract B, and water in a column body of 1.5, and then: ethanol = 1:1 elution 1 volume, water: eluting with ethanol=1:2 for 3 volumes, collecting eluate, concentrating, and drying to obtain extract;

s4: drying rhizoma Zingiberis recens and cortex Cinnamomi until the water content is less than 3%, pulverizing to 20 mesh, mixing with the extract and folic acid, and grinding into 50 mesh powder.

Example 4

35 parts of red date, 55 parts of beef bones, 8 parts of kelp, 20 parts of ginger, 5 parts of cinnamon and 0.5 part of calcium folate.

Hair growth and digestion promoting composition

S1: respectively crushing the red dates, the beef bones and the kelp by weight parts to 50 meshes, adding 780 parts of water, then adding 1M hydrochloric acid to adjust the pH value to be 4.5, heating and refluxing for extraction, monitoring the pH value of a system in a refluxing process, adding hydrochloric acid to enable the pH value to be 5 when the pH value of the system is more than 5, extracting for 4 hours, and filtering after the extraction is completed to obtain an extract A;

s2: concentrating the extract A to 1/3 under reduced pressure, adding 2M sodium hydroxide to adjust pH to 8, and stirring for 2 hr to obtain extract B;

s3: concentrating the extract B to 1/3, using a chromatographic column with C18 as a filler, wherein the filler amount is 1/3 of the volume of the extract B, desalting by using 2 column volumes of water, and then: ethanol = 1:1 elution 2 volumes, water: eluting with ethanol=1:2 for 4 volumes, collecting eluate, concentrating, and drying to obtain extract;

s4: drying rhizoma Zingiberis recens and cortex Cinnamomi until water content is less than 5%, pulverizing to 16 mesh, mixing with extract and folic acid, and grinding to 50 mesh powder.

Example 5

30 parts of red date, 50 parts of beef bones, 20 parts of kelp, 18 parts of ginger, 8 parts of cinnamon and 0.5 part of folic acid methyl ester.

Hair growth and digestion promoting composition

S1: respectively crushing the red dates, the beef bones and the kelp by weight parts to 50 meshes, adding 800 parts of water, then adding 1.5M hydrochloric acid to adjust the pH to be=4, heating and refluxing for extraction, monitoring the pH of a system in a refluxing process, adding hydrochloric acid to enable the pH to be=5 when the pH of the system is more than 5, extracting for 4 hours, and filtering after the extraction is completed to obtain an extract A;

s3: concentrating the extract B to 1/4, using a chromatographic column with C18 as a filler, wherein the filler amount is 1/4 of the volume of the extract B, desalting by using 2 column volumes of water, and then: ethanol = 1:1 elution 1 volume, water: eluting with ethanol=1:2 for 5 volumes, collecting eluate, concentrating, and drying to obtain extract;

Comparative example 1-the ratio of ginger to cinnamon was different from example 1

30 parts of red date, 60 parts of beef bone, 15 parts of kelp, 2 parts of ginger, 20 parts of cinnamon and 0.5 part of folic acid.

Hair growth and digestion promoting composition

Comparative example 2-the degree of acid modulation in S1 was different from that in example 1

Hair growth and digestion promoting composition

S1: respectively crushing the red dates, the beef bones and the kelp by weight parts to 40 meshes, adding 840 parts of water, then adding 3M hydrochloric acid to regulate pH to be 3, heating and refluxing for extraction, monitoring the pH of a system in a refluxing process, adding hydrochloric acid to ensure that the pH is 3 when the pH of the system is more than 5, extracting for 4 hours, and filtering after the extraction is completed to obtain an extract A;

Comparative example 3-pH was not monitored in S1 compared to example 1

Hair growth and digestion promoting composition

S1: respectively crushing the red dates, the beef bones and the kelp according to the weight parts to 40 meshes, adding 840 parts of water, then adding 3M hydrochloric acid to adjust the pH value to be 4, heating and refluxing for extraction for 4 hours, detecting to obtain an extraction system pH value to be 6, and filtering after the extraction is completed to obtain an extraction solution A;

Comparative example 4-the degree of alkali adjustment was different in S2 as compared with example 1

Hair growth and digestion promoting composition

s2: concentrating the extract A to 1/3 under reduced pressure, adding 3M sodium hydroxide to adjust pH to 10, and stirring for 2 hr to obtain extract B;

Comparative example 5-the column packing in S3 was different compared to example 1

Hair growth and digestion promoting composition

s3: concentrating the extract B to 1/4, using a chromatographic column with D101 resin as a filler, wherein the filler amount is 1/3 of the volume of the extract B, desalting by using 1 column of water, and then: ethanol = 1:1 elution 2 volumes, water: eluting with ethanol=1:2 for 2 volumes, collecting eluate, concentrating, and drying to obtain extract;

Effect example-alopecia preventing Effect

Effect example-mouse Hair growth experiment

The experimental animal is female C57BL/6 mouse, the weight is 20-22g, and three days before experiment are observed. During the experiment, the mice of each group are fed in a quiet environment, fed in separate cages, fed with common feed (meeting the requirement of GB 14924.3-2001 animal, mouse and rat compound feed) and fed with water freely. The drinking water and the feed are changed every day, so that the ventilation, the cleanness and the sanitation of the living environment of animals are maintained. The illumination is carried out in the daytime (12+/-2) hours, the indoor temperature (20+/-2) DEG C and the relative humidity (40% -60%). After one week of basal feeding of mice, the mice were randomly grouped

Under mild anesthesia, the rosin and paraffin mixture with the mass ratio of 1:1 is heated and melted and then is coated on the back of the mice, after the mixture is solidified and hardened, the mixture is gently removed, and the area of the dehairing area of each mouse is about 2X 2cm ² After dehairing, the dehairing agent is randomly grouped according to the weight, 5 dehairing agents are added into the dehairing agent in each group, the dosing scheme is that the dehairing agent is subjected to the stomach filling treatment once per day for a fixed time, and the dosage is 1g/kg ^. BW. The animals were continuously dosed for 21 days, sacrificed on day 22, the length and weight of the hair in the newly generated hair zone were measured, and the hair growth of each group of animals was observed daily, and the experimental results are shown in table 1.

TABLE 1 pilatory effect data

	Hair length (mm)	Gross weight (mg/m) ² )
			Example 1	10.9±1.2**	21.3±3.5**
Example 2	9.8±0.9*	21.0±3.3**
			Example 3	10.5±1.1**	20.6±2.9**
Example 4	9.1±0.8*	20.9±3.0**
			Example 5	9.3±0.9*	21.5±2.7**
Comparative example 1	8.8±0.7*	19.1±3.1*
			Comparative example 2	7.5±0.6	18.8±2.9*
Comparative example 3	8.3±0.9*	18.3±3.3*
			Comparative example 4	7.9±0.6*	18.7±2.7*
Comparative example 5	7.7±1.3	19.0±3.6*
			Blank control group	7.1±0.8	17.6±3.5

Compared with the blank control group: * P < 0.05, P < 0.01

As can be seen from the results of example 1 and comparative example 1, the composition of the present invention has unsatisfactory hair growth effect when the amounts of ginger and cinnamon are not suitable; the results of comparative examples 2-5 show that the degree of acidification and the method of desalination have a certain effect on the final composition of the composition during the preparation of the composition, thereby affecting the hair growth effect of the final composition.

Effect example-digestion-aiding test (refer to "health food inspection and evaluation technical Specification" (2003 edition) -digestion-promoting function inspection method)

Experimental animals: female SD rats, weighing 120-130g, 5 per group.

The feeding mode is as follows: and the normal feed (meeting GB 14924.3-2001 experimental animal, mouse and rat compound feed) is fed, and the animal is free to drink water.

The administration mode is as follows: according to the body weight, the administration is carried out by lavage for a fixed time every day, and the compression dose is 1g/kg BW.

The experimental method comprises the following steps: before and after the experiment, each group of rats is weighed, the weight gain and the food utilization rate are calculated, meanwhile, the digestive enzyme of each group of mice is measured, and the test method refers to the experimental method for determining the digestive enzyme in the technical Specification for inspection and evaluation of health food (2003).

The experimental results are shown in Table 2.

Table 2 digestion-aiding test results

	Weight gain/(g)	Feed rate/(g)	Food availability/(%)	Pepsin Activity/(μ/mL)
					Example 1	167.7±16.3**	653.5±36.3	25.9±6.1*	476±90.2**
Example 2	161.6±17.2**	655.7±37.4	24.8±5.6*	450±101.5**
					Example 3	164.5±18.9**	618.9±34.5	26.8±6.8**	481±85.4**
Example 4	154.6±13.5*	610.4±35.0	25.1±6.3*	489±80.3**
					Example 5	157.7±16.4*	573.5±35.8	28.1±7.7**	513±95.1**
Comparative example 1	136.7±13.5*	630.5±29.7	21.5±5.5*	386±76.7*
					Comparative example 2	149.3±15.0*	643.2±32.0	23.5±4.7*	415±89.5**
Comparative example 3	159.8±16.7*	643.5±33.3	24.4±4.9*	430±96.1**
					Comparative example 4	153.6±14.8*	630.7±32.5	24.5±5.6*	436±88.2**
Comparative example 5	156.3±15.6*	635.6±36.2	25.6±4.5*	424±83.1**
					Blank control group	118.8±12.3	624.3±30.5	18.5±3.6	320.4±86.5

Compared with the blank control group: * P < 0.05, P < 0.01

Compared with a blank control group, the invention has the advantages that the weight gain, the food utilization rate and the pepsin activity of rats are obviously improved (P is less than 0.05), so that the combination provided by the invention has the digestion-aiding effect.

Finally, it should be noted that the above description is only for illustrating the technical solution of the present invention, and not for limiting the scope of the present invention, and that the simple modification and equivalent substitution of the technical solution of the present invention can be made by those skilled in the art without departing from the spirit and scope of the technical solution of the present invention.

Claims

1. The composition for promoting hair growth and aiding digestion comprises the following raw materials in parts by weight:

30-40 parts of red dates, 35-60 parts of beef bones, 8-35 parts of kelp, 5-30 parts of ginger, 5-10 parts of cinnamon and 0.1-1 part of folic acid compounds;

the preparation method of the composition comprises the following steps,

s4: drying and pulverizing rhizoma Zingiberis recens and cortex Cinnamomi, mixing with the extract and folic acid compounds, and grinding into powder to obtain the composition;

in the S1, the crushing is carried out until the crushing is carried out to 40-60 meshes, the water consumption is 6-8 times of the total amount of the red dates, the beef bones and the kelp, the concentration of the hydrochloric acid is 1-3M, the pH is regulated to 4-5, and the reflux time is 4-6 hours;

in S2, the concentration is 1/4-1/3 of the volume of the extracting solution A, the concentration of sodium hydroxide is 1-3M, and the pH is regulated to 7-8.

2. The composition of claim 1, wherein the preparation raw materials consist of the following components in parts by weight:

3. The composition according to any one of claims 1 or 2, wherein the folic acid compound is one or more of folic acid, leucovorin, L-methyl folic acid, folic acid pharmaceutically acceptable salts.

4. A composition according to claim 3, wherein the folic acid compound is selected from at least one of folic acid, a pharmaceutically acceptable salt of folic acid, and methyl folate.

5. The composition according to any one of claims 1 or 2, wherein the composition further comprises at least one pharmaceutically acceptable excipient; the excipient is a diluent, binder, disintegrant, lubricant, colorant, flavoring agent, pH adjustor, buffering agent, homogenizing agent, preservative, anti-adhesive agent, glidant, acidulant, sweetener, or any combination thereof.

6. A process for preparing a composition according to any one of claim 1 to 5, comprising the steps of,

7. The preparation method according to claim 6, wherein in S3, the concentration is 1/4-1/3 of the volume of the extracting solution, the filler is 1/4-1/3 of the volume of the extracting solution B, water is used for desalting by 1-2 column volumes, and the volume ratio of water to ethanol in the water and ethanol mixed solution is 1:1-2, and the volume of the collected fraction column is 3-6 column volumes.

8. The method according to claim 6, wherein in S4, the powder is pulverized to 10-20 mesh, the powder is 40-60 mesh, and the dry content is less than 5%.