CN112891437A - Traditional Chinese medicine composition for treating gastric ulcer and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating gastric ulcer and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a traditional Chinese medicine composition for treating gastric ulcer, which comprises the following raw materials in parts by weight: 100 parts of paulownia leaves and 500 parts of paulownia leaves; 10-50 parts of rhubarb; 100 portions of dahurian patrinia herb and 500 portions of dahurian patrinia herb; 500 portions and 1000 portions of sesame oil. The traditional Chinese medicine composition for treating gastric ulcer provided by the invention can treat gastric ulcer, has small side effect, and can radically eliminate diseases and prevent relapse. The invention also provides a preparation method of the traditional Chinese medicine composition for treating gastric ulcer, and the prepared finished product has the same functions as the traditional Chinese medicine composition for treating gastric ulcer provided by the invention.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for treating gastric ulcer and a preparation method thereof.
Background
Gastric ulcer occurs in the digestive system and is a common stomach disease in clinic. It is a disease in which open ulcers appear on the inner wall of the stomach, and the incidence of the disease is high because of many pathogenic factors. Among them, helicobacter pylori infection is the most common pathogenic factor, and non-steroidal anti-inflammatory drugs, poor dietary habits, poor mood and the like are taken for a long time. The clinical symptoms of gastric ulcers are mainly seen in the digestive system, increasing patient discomfort, such as: stomach pain (aggravated after eating), abdominal distention, belching, nausea, anorexia, dyspepsia, emesis, hematochezia, and weight loss. If the clinical symptoms are serious, the breathing condition of the patient can be affected, the breathing difficulty of the patient is induced, and the life safety is threatened.
Gastric ulcer is mainly stomach mucosa tissue defect and necrotic lesion caused by stomach mucosa inflammation and helicobacter pylori infection, and the lesion can reach the mucosal muscularis deeply. The main clinical treatment mode of gastric ulcer is drug therapy, and drugs are adopted to protect gastric mucosa, resist bacteria and inhibit acid. Most of the existing medicines for treating gastric ulcer are western medicines, although the medicines have certain curative effect, the side effects are large, the recurrence rate is high after the medicines are stopped, once the state of an illness is repeated, the incidence rate of adverse reactions can be improved, severe conditions such as gastric perforation and gastrorrhagia can be caused, and adverse effects are caused on the life quality and life safety of patients. Some patients have persistent gastric ulcer or recurrent gastric ulcer, which is easy to become cancerous.
At present, a plurality of medicines can only eliminate the symptoms of surface pain without removing the root cause of the symptoms, and a plurality of patients are treated by medicines for a long time, the symptoms are only relieved, the symptoms cannot be radically eradicated, the symptoms are frequently relapsed, the side effects on the human body after long-term use are large, the symptoms are easy to relapse after treatment, and the symptoms are difficult to radically cure.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for treating gastric ulcer, which has the functions of detumescence and granulation promotion, fire purging and detoxification, and protective membrane and granulation promotion in the treatment of gastric ulcer, can treat gastric ulcer, has small side effect, and can radically eliminate diseases and prevent relapse.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating gastric ulcer, and the prepared finished product has the same effect as the traditional Chinese medicine composition for treating gastric ulcer provided by the invention.
The traditional Chinese medicine composition for treating gastric ulcer is characterized by comprising the following raw materials in parts by weight: 100 parts of paulownia leaves and 500 parts of paulownia leaves; 10-50 parts of rhubarb; 100 portions of dahurian patrinia herb and 500 portions of dahurian patrinia herb; 500 portions and 1000 portions of sesame oil.
The traditional Chinese medicine composition for treating gastric ulcer preferably comprises the following raw materials in parts by weight: 300 parts of paulownia leaf and 500 parts of medicinal material; 30-50 parts of rhubarb; 300 portions of dahurian patrinia herb and 500 portions of dahurian patrinia herb; 600 portions of sesame oil and 1000 portions of sesame oil.
Preferably, the paulownia leaf, the rheum officinale and the patrinia herb are ground and then used.
The above traditional Chinese medicine composition for treating gastric ulcer preferably further comprises a preparation auxiliary material, wherein the preparation auxiliary material is one of white vaseline, a chewing gum base, a tablet excipient and a spray propellant.
The preparation method of the traditional Chinese medicine composition for treating gastric ulcer is characterized by comprising the following steps:
a. weighing 500 parts by weight of paulownia leaf, 10-50 parts by weight of rhubarb, 500 parts by weight of dahurian patrinia herb and 1000 parts by weight of sesame oil;
b. pulverizing folium Paulowniae, radix et rhizoma Rhei and herba Patriniae, mixing, and fermenting for 0.1-5 hr to obtain mixture;
c. adding oleum Sesami into the mixture obtained in step b, mixing, heating at 64-74 deg.C for 8-10 hr, filtering while hot, and collecting filtrate.
The preparation method of the traditional Chinese medicine composition for treating gastric ulcer preferably further comprises the following steps: adding preparation auxiliary materials into the filtrate, and uniformly mixing.
In the preparation method of the traditional Chinese medicine composition for treating gastric ulcer, preferably, the preparation auxiliary material is one of white vaseline, a chewing gum base, a tablet excipient and a spray propellant.
The invention has the beneficial effects that:
the invention provides a traditional Chinese medicine composition for treating gastric ulcer, which mainly comprises paulownia leaves, rheum officinale, herba patriniae and sesame oil. Wherein the paulownia leaves can promote the healing of the damaged skin of the patient, shorten the treatment time, relieve the pain of the patient and reduce the infection. Paulownia leaf is suitable for wound surface, and can improve microcirculation, protect the metaecological tissue, convert the metaecological tissue into epithelial tissue with growth function, avoid further expansion of wound surface, and accelerate wound surface healing. Radix et rhizoma Rhei has antiinflammatory, pathogenic fire purging and toxic substance removing effects. Herba Patriniae has antibacterial, antiinflammatory, tranquilizing, antitumor, gastric mucosa protecting, pathological microcirculation improving, ulcer surface repairing promoting, and immunity enhancing effects. Compared with other edible oils, sesame oil has unique strong antioxidant capacity and inflammatory reaction inhibition property.
According to the traditional Chinese medicine composition for treating gastric ulcer, rheum officinale has the effects of purging fire and detoxifying, patrinia herb has the effects of eliminating carbuncle and removing stasis, sesame oil has the effect of astringing and protecting membranes, so that the effects of protecting the membranes and treating ulcer are achieved, and the traditional Chinese medicine composition is used together to synergistically clear away heat and toxic materials and protect the membranes and promote tissue regeneration, so that the gastric ulcer is effectively treated. Has small side effect, and can radically eliminate diseases and prevent relapse.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating gastric ulcer, and the prepared finished product has the same effect as the traditional Chinese medicine composition for treating gastric ulcer provided by the invention.
Detailed Description
In order to make those skilled in the art better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all embodiments.
All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The embodiment of the invention provides a traditional Chinese medicine composition for treating gastric ulcer, which comprises the following raw materials in parts by weight: 100 parts of paulownia leaves and 500 parts of paulownia leaves; 10-50 parts of rhubarb; 100 portions of dahurian patrinia herb and 500 portions of dahurian patrinia herb; 500 portions and 1000 portions of sesame oil.
The traditional Chinese medicine composition for treating gastric ulcer provided by the invention mainly comprises paulownia leaves, rheum officinale, herba patriniae and sesame oil. Wherein the paulownia leaf can promote the healing of the damaged skin of the patient, shorten the treatment time, relieve the pain of the patient and reduce the infection. The paulownia leaf is suitable for wound surface, can improve microcirculation, protect the metaecological tissue, convert the metaecological tissue into the epithelial tissue with growth function, avoid further expansion of the wound surface and accelerate the healing of the wound surface. Radix et rhizoma Rhei has antiinflammatory, pathogenic fire purging and toxic substance removing effects. Herba Patriniae has antibacterial, antiinflammatory, tranquilizing, antitumor, gastric mucosa protecting, pathological microcirculation improving, ulcer surface repairing promoting, and immunity enhancing effects. Compared with other edible oils, sesame oil has unique strong antioxidant capacity and inflammatory reaction inhibition property.
According to the traditional Chinese medicine composition for treating gastric ulcer, rheum officinale has the effects of purging fire and detoxifying, patrinia herb has the effects of eliminating carbuncle and removing stasis, sesame oil has the effect of astringing and protecting membranes, the effects of clearing away heat and toxic materials and protecting the membranes and promoting granulation are achieved by combining the medicines, and the gastric ulcer is effectively treated. Has small side effect, and can radically eliminate diseases and prevent relapse.
Preferably, the traditional Chinese medicine composition for treating gastric ulcer provided by the embodiment of the invention comprises the following raw materials in parts by weight: 300 parts of paulownia leaf and 500 parts of medicinal material; 30-50 parts of rhubarb; 300 portions of dahurian patrinia herb and 500 portions of dahurian patrinia herb; 600 portions of sesame oil and 1000 portions of sesame oil.
Preferably, paulownia leaf, rhubarb and patrinia are pulverized for use.
Preferably, the traditional Chinese medicine composition for treating gastric ulcer can further comprise a preparation auxiliary material, wherein the preparation auxiliary material is one of white vaseline, a chewing gum base, a tablet excipient and a spray propellant.
Wherein the Chinese medicinal composition can be mixed with white vaseline to make into unguent; mixing with chewing gum base to make into chewing agent; mixing with tablet excipient to make into tablet; mixing with propellant, and making into spray.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating gastric ulcer, which comprises the following steps:
a. weighing 500 parts by weight of paulownia leaf, 10-50 parts by weight of rhubarb, 500 parts by weight of dahurian patrinia herb and 1000 parts by weight of sesame oil;
b. pulverizing folium Paulowniae, radix et rhizoma Rhei and herba Patriniae, mixing, and fermenting for 0.1-5 hr to obtain mixture;
c. adding oleum Sesami into the mixture obtained in step b, mixing, heating at 64-74 deg.C for 8-10 hr, filtering while hot, and collecting filtrate.
The preparation method of the traditional Chinese medicine composition for treating gastric ulcer can also comprise the following steps: adding adjuvants into the filtrate, and mixing.
Wherein the preparation adjuvant is one of white vaseline, chewing gum base, tablet excipient and spray propellant. Wherein, when the preparation adjuvant is white vaseline, it can be made into paste; when the adjuvant is chewing gum base, it can be made into chewing agent; when the preparation adjuvant is tablet excipient, the preparation adjuvant can be made into tablet; when the adjuvant is spray, the preparation can be made into spray.
According to the preparation method of the traditional Chinese medicine composition for treating gastric ulcer, rheum officinale is used for purging fire and detoxifying, patrinia is used for eliminating carbuncle and removing stasis, sesame oil is used for astringing and protecting membranes, the effect of protecting the membranes and treating ulcer is achieved, the medicines are used together, the heat and the detoxification are achieved under the synergistic effect, the membranes are protected, tissue regeneration is achieved, and the gastric ulcer is effectively treated. Has small side effect, and can radically eliminate diseases and prevent relapse.
Example 1
A traditional Chinese medicine composition for treating gastric ulcer comprises the following raw materials in parts by weight:
the preparation method comprises the following steps:
a. pulverizing folium Paulowniae, radix et rhizoma Rhei and herba Patriniae, mixing, and fermenting for 2 hr to obtain mixture;
b. and (b) adding sesame oil into the mixture obtained in the step a, uniformly mixing, heating at 70 ℃ for 9 hours, filtering while hot, and taking the filtrate to obtain the traditional Chinese medicine composition.
Example 2
A traditional Chinese medicine composition for treating gastric ulcer comprises the following raw materials in parts by weight:
the preparation method comprises the following steps:
a. pulverizing folium Paulowniae, radix et rhizoma Rhei and herba Patriniae, mixing, and fermenting for 3 hr to obtain mixture;
b. and (b) adding sesame oil into the mixture obtained in the step a, uniformly mixing, heating at 70 ℃ for 10 hours, filtering while hot, and taking the filtrate to obtain the traditional Chinese medicine composition.
Example 3
A traditional Chinese medicine composition for treating gastric ulcer comprises the following raw materials in parts by weight:
the preparation method comprises the following steps:
a. pulverizing folium Paulowniae, radix et rhizoma Rhei and herba Patriniae, mixing, and fermenting for 5 hr to obtain mixture;
b. and (b) adding sesame oil into the mixture obtained in the step a, uniformly mixing, heating at 74 ℃ for 10 hours, filtering while hot, and taking the filtrate to obtain the traditional Chinese medicine composition.
Example 4
(1) Selecting a rat: selecting healthy male Wistar rats with the weight of 220-280 g. The rats are first placed in a quiet animal room to be kept in cage, the room temperature is controlled to be 22 +/-2 ℃, the natural rhythm illumination is carried out, free food and water are taken, standard feed is fed, after the rat is adapted for 1 week, formal experiments are carried out, and fasting is carried out for 24 hours before the experiment, and water is fed freely.
(2) Grouping experiments: experimental rats were randomly divided into a normal group, a model group, a paulownia leaf group, a rhubarb group, a patrinia group, a hemp oil group, a composition 1 group, a composition 2 group, a composition 3 group, and an omeprazole group.
(3) Preparing a medicament: medicaments with different doses are prepared, and the medicament dose of each group is shown in table 1, wherein the composition 1 group, the composition 2 group and the composition 3 group are prepared by the preparation method of the traditional Chinese medicine composition for treating gastric ulcer provided by the invention.
(4) Preparation of acetic acid gastric ulcer model in rat
Each group of rats was anesthetized with 10% chloral hydrate solution according to 2mL/kg standard, attached to the operating table, the thoracic and abdominal areas were exposed, the left flank and abdominal area were disinfected with iodophors, 3cm incisions were cut, the muscular layers were exposed, the muscular layers were cut open, and the stomach was pulled out of the abdominal cavity with forceps and flattened. Injecting 100% glacial acetic acid 0.02mL at the junction of antrum and body of stomach until the serosa layer of stomach has white ulcer ring of about 3mm, placing the stomach in abdominal cavity, suturing muscle layer and skin layer by layer, and sterilizing with iodophor. The rats in the normal group were subjected to a sham operation, which was performed as before, but only the abdominal cavity was opened, and after exposing the stomach, glacial acetic acid was not injected and then sutured.
(5) Administration: and starting intragastric administration 24h after the model building, wherein the normal group and the model group are infused with distilled water with the same volume, and the total administration time is 15 days.
(6) And (3) determining the ulcer index: after 2h of the last administration, 10% chloral hydrate is used for intraperitoneal injection and anesthesia, the abdomen is cut open, then the stomach is taken out, the stomach is cut along the greater curvature of the stomach, the content of the stomach is slightly washed away by normal saline, the inner side surface of the stomach wall is flattened, mucus and blood clots on the gastric mucosa are slightly wiped away by a small cotton ball, and the injury degree of the gastric mucosa is observed. The longest diameter and widest diameter of the gastric ulcer site were measured with a ruler, and the Ulcer Index (UI) was determined as longest diameter × shortest diameter × 1/4 × pi.
TABLE 1 measurement of ulcer index in rats
Note: p < 0.05, P < 0.01 compared with the model group; compared with omeprazole group, the delta P is less than 0.05.
As a result: compared with the model control group, the ulcer index of the composition 3 group is reduced (P < 0.05), the ulcer index of the composition 1 group, the ulcer index of the composition 2 group and the ulcer index of the omeprazole group are obviously reduced (P < 0.01), and the ulcer index of the composition 1 group is improved to a degree superior to that of the omeprazole group (P < 0.05) and each component is singly used.
The Chinese medicinal composition for treating gastric ulcer and the preparation method thereof provided by the invention are described in detail above. The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
Claims (7)
1. The traditional Chinese medicine composition for treating gastric ulcer is characterized by comprising the following raw materials in parts by weight: 100 parts of paulownia leaves and 500 parts of paulownia leaves; 10-50 parts of rhubarb; 100 portions of dahurian patrinia herb and 500 portions of dahurian patrinia herb; 500 portions and 1000 portions of sesame oil.
2. The traditional Chinese medicine composition for treating gastric ulcer according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 300 parts of paulownia leaf and 500 parts of medicinal material; 30-50 parts of rhubarb; 300 portions of dahurian patrinia herb and 500 portions of dahurian patrinia herb; 600 portions of sesame oil and 1000 portions of sesame oil.
3. The Chinese medicinal composition for treating gastric ulcer according to any one of claims 1 to 2, wherein the paulownia leaf, rhubarb and patrinia are pulverized for use.
4. The traditional Chinese medicine composition for treating gastric ulcer according to any one of claims 1 to 3, further comprising a preparation adjuvant, wherein the preparation adjuvant is one of white vaseline, chewing gum base, tablet excipient and spray propellant.
5. A method for preparing the traditional Chinese medicine composition for treating gastric ulcer as claimed in any one of claims 1 to 4, which comprises the following steps:
a. weighing 500 parts by weight of paulownia leaf, 10-50 parts by weight of rhubarb, 500 parts by weight of dahurian patrinia herb and 1000 parts by weight of sesame oil;
b. pulverizing folium Paulowniae, radix et rhizoma Rhei and herba Patriniae, mixing, and fermenting for 0.1-5 hr to obtain mixture;
c. adding oleum Sesami into the mixture obtained in step b, mixing, heating at 64-74 deg.C for 8-10 hr, filtering while hot, and collecting filtrate.
6. The method for preparing a Chinese medicinal composition for treating gastric ulcer as claimed in claim 5, further comprising the steps of: adding preparation auxiliary materials into the filtrate, and uniformly mixing.
7. The method for preparing a Chinese medicinal composition for treating gastric ulcer as claimed in claim 6, wherein the formulation auxiliary material is one of white vaseline, gum base of chewing gum, tablet excipient and propellant of spray.
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| CN114732857A (en) * | 2022-05-30 | 2022-07-12 | 湘西自然生物科技有限公司 | Novel bacteriostatic traditional Chinese medicine composition and preparation method and application thereof |
| CN116920049A (en) * | 2023-07-12 | 2023-10-24 | 中南民族大学 | Skin-care oil for treating gastric ulcer and preparation method and application thereof |
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| CN114732857A (en) * | 2022-05-30 | 2022-07-12 | 湘西自然生物科技有限公司 | Novel bacteriostatic traditional Chinese medicine composition and preparation method and application thereof |
| CN116920049A (en) * | 2023-07-12 | 2023-10-24 | 中南民族大学 | Skin-care oil for treating gastric ulcer and preparation method and application thereof |
| CN116920049B (en) * | 2023-07-12 | 2024-05-31 | 中南民族大学 | Skin-care oil for treating gastric ulcer and preparation method and application thereof |
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