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CN112871926B - Cleaning method of medical cylindrical rubber product - Google Patents

Cleaning method of medical cylindrical rubber product Download PDF

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Publication number
CN112871926B
CN112871926B CN202110160142.4A CN202110160142A CN112871926B CN 112871926 B CN112871926 B CN 112871926B CN 202110160142 A CN202110160142 A CN 202110160142A CN 112871926 B CN112871926 B CN 112871926B
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cleaning
air
product
medical
cylindrical rubber
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CN112871926A (en
Inventor
马东风
李向阳
黄新景
刘梅玲
李亚珂
申玉姣
杨明真
李志会
陈帅立
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Zhengzhou Huajing New Material Technology Co ltd
Zhengzhou Aoxiang Pharmaceutical Packing Co ltd
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Zhengzhou Huajing New Material Technology Co ltd
Zhengzhou Aoxiang Pharmaceutical Packing Co ltd
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00Cleaning hollow articles by methods or apparatus specially adapted thereto
    • B08B9/08Cleaning containers, e.g. tanks
    • B08B9/20Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
    • B08B9/28Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by splash, spray, or jet application, with or without soaking
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B13/00Accessories or details of general applicability for machines or apparatus for cleaning
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04Cleaning involving contact with liquid
    • B08B3/08Cleaning involving contact with liquid the liquid having chemical or dissolving effect
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04Cleaning involving contact with liquid
    • B08B3/10Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04Cleaning involving contact with liquid
    • B08B3/10Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
    • B08B3/12Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration by sonic or ultrasonic vibrations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00Cleaning hollow articles by methods or apparatus specially adapted thereto
    • B08B9/08Cleaning containers, e.g. tanks
    • B08B9/0804Cleaning containers having tubular shape, e.g. casks, barrels, drums
    • B08B9/0813Cleaning containers having tubular shape, e.g. casks, barrels, drums by the force of jets or sprays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00Cleaning hollow articles by methods or apparatus specially adapted thereto
    • B08B9/08Cleaning containers, e.g. tanks
    • B08B9/20Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought
    • B08B9/28Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by splash, spray, or jet application, with or without soaking
    • B08B9/283Cleaning containers, e.g. tanks by using apparatus into or on to which containers, e.g. bottles, jars, cans are brought the apparatus cleaning by splash, spray, or jet application, with or without soaking by gas jets

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cleaning By Liquid Or Steam (AREA)

Abstract

The invention discloses a cleaning method of a medical cylindrical rubber product, which is characterized by comprising the following steps: (1) feeding; (2) rough washing; (3) ultrasonic defoaming; (4) air-blast cleaning; (5) rinsing; (6) air-blast silicification; (7) and (5) drying in vacuum. And drying to obtain the medical cylindrical rubber product with clean outer surface and inner control and uniform silicification. The medical cylindrical rubber product is generally in a slender cylinder or cone structure, a through hole or a blind hole is arranged in the medical cylindrical rubber product, and grooves, pits, bulges and other structures can be arranged on the inner surface and the outer surface of the medical cylindrical rubber product. This structure can affect the cleaning and siliconizing effect, and seriously affect the use and safety of the medical component. The method can solve the problems, the inner surface of the cleaned medical cylindrical rubber product is clean and is uniformly siliconized, and the adverse effect on the whole medical product caused by poor cleaning effect or nonuniform siliconization of the rubber product is avoided.

Description

Cleaning method of medical cylindrical rubber product
Technical Field
The invention relates to the field of medical rubber products, in particular to a cleaning method of a medical cylindrical rubber product.
Background
Medical rubber articles are widely used, such as: the medical rubber product is characterized by comprising a silica gel catheter, an injector connector, a delivery pump connecting pipe, an injection needle protective cap, a pre-filled and sealed injector rubber assembly and the like, wherein a part of medical rubber products are in a cylindrical structure, namely a cylinder or cone structure, a through hole or a blind hole is formed in the medical rubber products, and grooves, pits, bulges and other structures can be formed in the inner surface and the outer surface of the medical rubber products. The medical rubber products are used as packaging materials or apparatuses which are directly contacted with medicines or human bodies, and the use safety of the medical rubber products is directly influenced by the cleanliness. In addition, the assembling performance of a part of medical rubber products as one of the combined components of the complete system directly influences the service performance of the whole system. Because the rubber product has a large friction coefficient, when the rubber product is installed and assembled with other products, the friction force is large, and the automatic production can be hindered. The assembly properties between it and other articles are generally improved by siliconizing its surface. Whether the surface of the product is siliconized and the uniformity of siliconization are thus critical to the assembling performance of the medical rubber product.
At present, a roller cleaning machine or an ultrasonic cleaning machine is generally adopted for cleaning medical rubber products, and the products to be siliconized are siliconized by adding a proper amount of silicone oil into pure water, heating and stirring, and the method is used for cleaning the medical rubber products of which the outer surfaces only need to be cleaned, such as: the rubber plug, the piston, the gasket, the plug and the like have good effects and are easy to implement. However, for cylindrical rubber products with holes or hollow interiors, the inner walls of the holes on the products are difficult to clean or siliconize due to the slender structure of the products. The inner wall of the product usually directly contacts the connection part of medicines, human bodies or other medical products, so the cleanness and the silicification effect of the inner wall of the hole of the medical cylindrical rubber product directly determine the use safety and the assembly convenience of the product.
Disclosure of Invention
The invention aims to overcome the defects in the prior art, provides a method for cleaning a medical cylindrical rubber product with excellent cleaning effect and uniform silicification, and solves the problems of poor cleaning effect, incapability of silicification or non-uniform silicification of the inner wall of the medical cylindrical rubber product.
In order to solve the technical problems, the invention adopts the following technical scheme:
a cleaning method of a medical cylindrical rubber product comprises the following steps:
(1) feeding: feeding a product to be cleaned into a cleaning machine by using a feeding machine;
(2) rough washing: after pure water is introduced into the cleaning machine, the steps of rotating, spraying, rinsing and the like are carried out, and the product is primarily cleaned by repeating for 1-3 times;
(3) ultrasonic defoaming: turning on an ultrasonic device under the condition of keeping the inner cylinder of the cleaning machine rotating, shattering and discharging bubbles in product holes through sound waves, and turning off the ultrasonic device after ultrasonic treatment for 5-10 min;
(4) air-blast cleaning: adding a prepared cleaning agent, vacuumizing the interior of the cleaning machine, rotating the inner cylinder of the cleaning machine, opening a gas release valve to enable purified clean air to enter from a gas inlet of a gas flushing pipe and to be discharged from a gas outlet, enabling the gas to drive pure water added with the cleaning agent to impact a product, repeating the steps, and cleaning the interior of a product hole through the impact of the gas and the liquid;
(5) rinsing: discharging liquid in the cleaning machine, re-injecting pure water, and after rotating, spraying and rinsing, performing air-blast cleaning in the step (4) again under the condition of no cleaning agent, so as to thoroughly clean cleaning agent possibly remained in the product;
(6) air-blast silicification: heating pure water in the cleaning machine, adding emulsified silicone oil according to the dosage, vacuumizing, rotating the inner cylinder for 1-3min, opening an air release valve, performing gas-liquid mixed impact, keeping the inner cylinder in a rotating state in the impact process, repeating vacuumizing and impact, and discharging liquid in the cleaning machine;
(7) and (3) vacuum drying: introducing clean hot air into the cleaning machine for drying, and then vacuumizing, wherein the process is circulated for 4-10 times;
further, in the air-blast cleaning in the step (4), the vacuum degree is pumped to be below-0.09 Mpa, the vacuum pumping time is 5-15min, and the mass concentration of the cleaning agent is 1-5%.
Further, in the step (4), the air flushing pipe is arranged at the bottom of the inner barrel of the cleaning machine, the air flushing pipe is arranged inside the charging barrel, an air inlet (1) and an exhaust hole (2) are formed in the air flushing pipe, and a release valve is arranged on the air inlet pipe.
Further, in the air-blast type silicification in the step (6), pure water is heated to 70-90 ℃, the mass concentration of the emulsified silicone oil is 0.5% -5%, the vacuum degree is pumped to be below-0.09 Mpa, and the vacuum pumping time is 5-15 min.
Further, the repetition times of vacuumizing and impacting in the step (4) are 2-5 times, and the repetition times are more when the diameter of the product is smaller.
Further, the repetition times of the vacuum pumping and the impacting in the step (6) are 1-3 times.
Further, in the step (7), the vacuum degree is reduced to-0.02 to-0.05 Mpa, and the vacuum time is 3 to 5 min.
And (7) introducing clean hot air into the washing machine for drying, and then vacuumizing, wherein the process is circulated for 4-10 times.
The invention has the beneficial effects that: the medical cylindrical rubber product is generally in a slender cylinder or cone structure, a through hole or a blind hole is arranged in the medical cylindrical rubber product, and grooves, pits, bulges and other structures can be arranged on the inner surface and the outer surface of the medical cylindrical rubber product. This structure can affect the cleaning and siliconizing effect, and seriously affect the use and safety of the medical component. The method comprises the steps of utilizing an ultrasonic device of a cleaning machine to shatter and discharge bubbles in holes of a cleaned product, then vacuumizing, utilizing an air flushing pipe arranged at the bottom of the cleaning machine to convey pressure gas to the bottom of the product, driving liquid around the product to flow rapidly through the impact of the gas, realizing rapid exchange in the holes of the product at night, and then assisting with a cleaning agent to achieve the effect of thoroughly cleaning the inner surface and the outer surface of a medical cylindrical rubber product, and simultaneously realizing the effect of uniformly silicifying the inner surface and the outer surface of the product by utilizing the method. The safety problem possibly caused by unclean products is solved, and the assembly problem of the products and other products which are matched with each other for use is also solved.
Drawings
FIG. 1 is a schematic view of the structure of an air blast pipe according to the present invention. Wherein, 1 is an air inlet, and 2 is an air outlet.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.
Example 1
A cleaning method of a medical cylindrical rubber product comprises the following steps:
(1) feeding: feeding 500 silicone tubes (wherein the inner walls of 100 holes are dyed by water-soluble fuel) with the diameter of 6.5mm and the length of 15mm into a cleaning machine by using a feeding machine;
(2) rough washing: after pure water is introduced into the cleaning machine, the steps of rotating, spraying, rinsing and the like are carried out, and the product is primarily cleaned by repeating for 2 times;
(3) ultrasonic defoaming: turning on an ultrasonic device under the condition of keeping the inner cylinder of the cleaning machine rotating, shattering and discharging bubbles in product holes through sound waves, and turning off the ultrasonic device after ultrasonic treatment for 5 min;
(4) air-blast cleaning: adding a prepared cleaning agent (Japanese Sun brand) with the mass concentration of 1%, vacuumizing the interior of a cleaning machine until the vacuum degree is-0.095 Mpa, vacuumizing for 5min, rotating the inner cylinder of the cleaning machine, opening a vent valve to enable purified clean air to enter from an air inlet 1 of an air flushing pipe and to be discharged from an air outlet 2, enabling the air to drive pure water added with the cleaning agent to impact a product, repeating the step for 2 times, and cleaning the interior of a hole of the product through the impact of the air and liquid;
(5) rinsing: discharging liquid in the cleaning machine, re-injecting pure water, performing rotation, spraying and rinsing, then performing air-blast cleaning in the step (4) again under the condition of no cleaning agent, repeating for 2 times, and thoroughly cleaning the cleaning agent possibly remained in the product;
(6) air-blast silicification: heating pure water in a cleaning machine, adding 70ml of emulsified silicone oil with the mass concentration of 0.5%, vacuumizing to the vacuum degree of-0.095 Mpa for 5min, rotating the inner cylinder for 1min, then opening an air release valve, performing gas-liquid mixed impact, keeping the inner cylinder in a rotating state in the impact process, repeating vacuumizing and impacting for 1 time, and discharging liquid in the cleaning machine.
(7) And (3) vacuum drying: introducing clean hot air into the cleaning machine for drying, and then vacuumizing to the vacuum degree of-0.02 Mpa, wherein the process is circulated for 4 times.
The obtained silicone tube is compared with a silicone tube (comparative example 1) which is cleaned by a common cleaning method and treated in the same way, the silicone tube is thrown along the middle shaft during comparison, the cleaning effect of 100 dyed products is checked, the obtained result is shown in table 1, in addition, 20 samples are extracted from 400 products for detecting the silicification effect, the extraction force is tested after the silicone tube is assembled with a matched component, the obtained result is shown in table 2, 100 extracted products are used for detecting the conductivity, the clarity and the particles according to the national medicine package material detection standard, and the obtained result is shown in table 3.
Example 2
A cleaning method of a medical cylindrical rubber product comprises the following steps:
(1) feeding: feeding 500 rubber protective caps (100 holes of which the inner wall is dyed by water-soluble fuel) with the outer diameter of 6mm and the length of 17.5mm into a cleaning machine by using a feeding machine;
(2) rough washing: after pure water is introduced into the cleaning machine, the steps of rotating, spraying, rinsing and the like are carried out, and the product is primarily cleaned by repeating for 3 times;
(3) ultrasonic defoaming: turning on an ultrasonic device under the condition of keeping the inner cylinder of the cleaning machine rotating, shattering and discharging bubbles in product holes through sound waves, and turning off the ultrasonic device after ultrasonic treatment for 8 min;
(4) air-blast cleaning: adding a prepared cleaning agent (Japanese Sun brand) with the mass concentration of 3%, vacuumizing the interior of a cleaning machine until the vacuum degree is-0.1 Mpa for 12min, rotating an inner cylinder of the cleaning machine, opening a vent valve to enable purified clean air to enter from an air inlet 1 of an air flushing pipe and to be discharged from an air outlet 2, enabling the air to drive pure water added with the cleaning agent to impact a product, repeating the step for 3 times, and cleaning the interior of a hole of the product through the impact of the air and liquid;
(5) rinsing: discharging liquid in the cleaning machine, re-injecting pure water, performing rotation, spraying and rinsing, then performing air-blast cleaning of the step 4 again under the condition of no cleaning agent, repeating for 3 times, and thoroughly cleaning the cleaning agent possibly remained in the product;
(6) air-blast silicification: heating pure water in a cleaning machine, adding 100ml of emulsified silicone oil with the mass concentration of 0.8%, vacuumizing until the vacuum degree is-0.1 Mpa, vacuumizing for 12min, rotating an inner cylinder for 3min, then opening an air release valve, carrying out gas-liquid mixed impact, keeping the inner cylinder in a rotating state in the impact process, repeating vacuumizing and impact for 2 times, and discharging liquid in the cleaning machine.
(7) And (3) vacuum drying: introducing clean hot air into the cleaning machine for drying, and then vacuumizing to the vacuum degree of-0.05 Mpa, wherein the process is circulated for 8 times.
The obtained rubber protective cap is compared with a rubber protective cap (comparative example 2) which is cleaned by a common cleaning method and is treated in the same way, the rubber protective cap is thrown away along the central axis during comparison, the cleaning effect of 100 dyed products is checked, in addition, 20 samples are extracted from 400 products for detecting the silicification effect, the extraction force is tested after the products are assembled with matched components, the obtained result is shown in a table 2, 100 samples of the rest products are extracted for detecting the conductivity, the clarity and the particles according to the national medicine package detection standard, and the obtained result is shown in a table 3.
TABLE 1 comparison of cleaning Effect of dyed articles
Figure 201550DEST_PATH_IMAGE002
TABLE 2 comparison of pullout force test results
Figure 446586DEST_PATH_IMAGE004
TABLE 3 comparison of results of conductivity, clarity, and particle measurements
Figure 695165DEST_PATH_IMAGE006
From the test results, the product cleaned by the method has the advantages that the cleaning degree, the extraction force, the conductivity, the clarity and the particles of the product cleaned by the method are superior to those of the product cleaned by the common method, and the obvious advantages are achieved.
The foregoing shows and describes the general principles and features of the present invention, together with the advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (5)

1. A cleaning method of a medical cylindrical rubber product is characterized by comprising the following steps:
(1) feeding: feeding a product to be cleaned into a cleaning machine by using a feeding machine;
(2) rough washing: after pure water is introduced into the cleaning machine, the steps of rotating, spraying and rinsing are carried out, and the product is primarily cleaned by repeating for 1-3 times;
(3) ultrasonic defoaming: turning on an ultrasonic device under the condition of keeping the inner cylinder of the cleaning machine rotating, shattering and discharging bubbles in product holes through sound waves, and turning off the ultrasonic device after ultrasonic treatment for 5-10 min;
(4) air-blast cleaning: firstly adding a prepared cleaning agent, vacuumizing the interior of the cleaning machine, then rotating the inner cylinder of the cleaning machine, opening a gas release valve to enable purified clean air to enter from a gas inlet (1) of a gas flushing pipe and to be discharged from a gas outlet (2), enabling the gas to drive pure water added with the cleaning agent to impact a product, repeatedly vacuumizing and impacting, and cleaning the interior of a product hole through the impact of gas and liquid;
(5) rinsing: discharging liquid in the cleaning machine, re-injecting pure water, and after rotating, spraying and rinsing, performing air-blast cleaning in the step (4) again under the condition of no cleaning agent, so as to thoroughly clean cleaning agent possibly remained in the product;
(6) air-blast silicification: heating pure water in a cleaning machine, adding emulsified silicone oil according to the dosage, vacuumizing, rotating the inner cylinder for 1-3min, opening an air release valve, performing gas-liquid mixed impact, keeping the inner cylinder in a rotating state in the impact process, repeating vacuumizing and impact, and discharging liquid in the cleaning machine;
(7) and (3) vacuum drying: introducing clean hot air into the cleaning machine for drying, and then vacuumizing;
in the step (4), in the air-blast cleaning, the vacuum degree is pumped to be below-0.09 Mpa, the vacuum pumping time is 5-15min, and the mass concentration of the cleaning agent is 1-5%;
in the step (4), the air flushing pipe is arranged at the bottom of the inner cylinder of the cleaning machine and is provided with an air inlet (1) and an air outlet (2);
in the air-blast type silicification in the step (6), pure water is heated to 70-90 ℃, the mass concentration of the emulsified silicone oil is 0.5-5%, the vacuum degree is pumped to be below-0.09 Mpa, and the vacuum pumping time is 5-15 min.
2. The method for cleaning a medical cylindrical rubber product according to claim 1, wherein: in the step (4), the repetition times of vacuumizing and impacting are 2-5 times, and the repetition times are more when the diameter of the product is smaller.
3. The method for cleaning a medical cylindrical rubber product according to claim 1, wherein: and (4) in the step (6), the repeated times of vacuumizing and impacting are 1-3 times.
4. The method for cleaning a medical cylindrical rubber product according to claim 1, wherein: in the step (7), the vacuum degree is reduced to-0.02 to-0.05 Mpa, and the vacuum time is 3 to 5 min.
5. The method for cleaning a medical cylindrical rubber product according to claim 1, wherein: and (7) introducing clean hot air into the washing machine for drying, and then vacuumizing, wherein the process is circulated for 4-10 times.
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CN115463891A (en) * 2022-09-07 2022-12-13 宁波正力药品包装有限公司 Cleaning equipment and cleaning method for syringe needle protective cap

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CN109731832A (en) * 2018-12-27 2019-05-10 扬州一洋制药有限公司 A kind of di-lysine-aspirin production processing method of rubber plug
CN110694996A (en) * 2019-10-16 2020-01-17 湖北华强科技有限责任公司 Cleaning process of butyl rubber plug with high cleanliness
CN111674062A (en) * 2020-05-28 2020-09-18 郑州翱翔医药科技股份有限公司 Silicification method of rubber cone head protective cap for pre-filling and sealing injector
CN212310229U (en) * 2020-04-15 2021-01-08 四川正基有机硅有限公司 Cleaning device for silica gel product

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Publication number Priority date Publication date Assignee Title
CN107744982A (en) * 2017-10-24 2018-03-02 安徽咏鹅家纺股份有限公司 A kind of more half tone cleaning devices
CN109731832A (en) * 2018-12-27 2019-05-10 扬州一洋制药有限公司 A kind of di-lysine-aspirin production processing method of rubber plug
CN110694996A (en) * 2019-10-16 2020-01-17 湖北华强科技有限责任公司 Cleaning process of butyl rubber plug with high cleanliness
CN212310229U (en) * 2020-04-15 2021-01-08 四川正基有机硅有限公司 Cleaning device for silica gel product
CN111674062A (en) * 2020-05-28 2020-09-18 郑州翱翔医药科技股份有限公司 Silicification method of rubber cone head protective cap for pre-filling and sealing injector

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