CN112842336A - Blood collection bottle for blood collection in immune cell therapy - Google Patents
Blood collection bottle for blood collection in immune cell therapy Download PDFInfo
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- CN112842336A CN112842336A CN202110038533.9A CN202110038533A CN112842336A CN 112842336 A CN112842336 A CN 112842336A CN 202110038533 A CN202110038533 A CN 202110038533A CN 112842336 A CN112842336 A CN 112842336A
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- bottle
- blood
- blood collection
- tube
- sampling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
- A61B5/154—Devices using pre-evacuated means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150061—Means for enhancing collection
- A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150221—Valves
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention relates to the technical field of blood collection bottles for blood collection, in particular to a blood collection bottle for immune cell therapy. The invention aims to solve the technical problems that sampling is inconvenient to perform experimental analysis, the safety coefficient of the blood taking needle is low, the manufacturing cost is high, and the volume production is not suitable. In order to solve the technical problems, the invention provides a blood collection bottle for immune cell therapy blood collection, which comprises a bottle body, wherein a blood collection mechanism is inserted at the top end of the bottle body, a cap is connected to the top of the bottle body in an overlapping mode, and the cap is movably sleeved on the periphery of the blood collection mechanism.
Description
Technical Field
The invention relates to the technical field of blood collection bottles for blood collection, in particular to a blood collection bottle for immune cell therapy.
Background
The immune cells in human bodies of people have the ability of resisting viruses, and the virus can be continuously existed in the human bodies only when the immune function is low and the virus is attacked, the biological immune cell therapy can induce the self-anti-virus immune response through in vitro culture, multiplication and activation and is infused back into the human bodies, the anti-virus substances can be continuously generated to kill the viruses once the anti-virus immunity of the human bodies is activated, the activated immune cells are infused back into the human bodies through the in vitro separation, incubation, multiplication and activation of the autologous blood in the autoimmune cell therapy, the effect of clearing the viruses is achieved, the anti-virus substances are continuously generated in the human bodies, the effects of thoroughly clearing the in-vivo viruses and turning the anions into the anions without rebound are finally achieved, and therefore, a device convenient for blood sampling is needed.
The prior patent (publication number: CN208500979U) discloses a blood collection bottle for blood collection for autoimmune cell therapy, and the prior art has at least the following problems which are not solved: 1. the blood plasma is transferred into the blood plasma sampling bottle and cannot be used immediately, multiple sampling and experimental analysis are needed, the existing blood sampling bottle is simple in structure, and the blood plasma in the blood sampling bottle is easily polluted in the repeated operation process, so that the experimental data is inaccurate; 2. the existing blood collection bottle and the existing blood collection needle are directly connected, after the blood collection operation is finished, the needle head cannot be discarded independently, and needs to be sealed by a fragile cover, so that medical accidents are easily caused due to improper operation, and the safety factor is lower; 3. the blood sampling bottle is disposable medical consumables, and is equipped with pressure sensor in the current blood sampling bottle, and pressure sensor and PLC display controller control connection, and the cost of manufacture is higher, and not suitable volume production practicality is not strong, can't conveniently realize the adjustment of different sample volumes when taking a sample among the prior art in addition.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a blood collection bottle for immune cell therapy blood collection, which solves the problems that the sampling is inconvenient to perform experimental analysis, the safety coefficient of the blood collection needle is low, the manufacturing cost is high, and the volume production is not suitable.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: the utility model provides an immune cell therapy is blood sampling with heparin bottle, includes the bottle, the blood sampling mechanism has been pegged graft on the top of bottle, the top overlap joint of bottle has the block, and the block activity cup joints the periphery at blood sampling mechanism, spacing arch has been seted up to the outer wall of bottle, positioning groove has been seted up at the edge of block bottom, spacing protruding joint is in positioning groove.
Blood sampling mechanism includes sealed cap, and sealed cap pegs graft at the top of bottle, sealed cap internal fixation alternates there are heparin tube, blast pipe and sampling tube, and the top of sampling tube runs through the blast pipe and rather than inside intercommunication, the one end difference fixedly connected with of heparin tube, blast pipe and sampling tube luer joint, first check valve and the second check valve rather than inside intercommunication.
The luer connector, the first one-way valve and the second one-way valve are fixedly connected with an injector connector communicated with the interior of the sampling tube, the other end of the injector connector is sleeved with a sealing protective cover, the sampling tube is obliquely arranged on one side of the exhaust tube and is of a Chinese character 'bo' structure, the bottom end of the sampling tube is fixedly connected with the second one-way valve and is communicated with the interior of the second one-way valve, the submerged extension depth of the exhaust tube in the bottle body is larger than that of the blood sampling tube, the blood sampling tube and the exhaust tube are arranged in parallel, the sampling tube is obliquely arranged on one side of the exhaust tube and is of a Chinese character 'bo' structure, the bottom end of the sampling tube is fixedly connected with the second one-way valve and is communicated with the interior of the second one-way valve, the bottom end of the exhaust tube penetrates through the sealing cap and extends to the bottom of the inner wall of the exhaust tube, the inner, an outer magnetic ring is sleeved on the outer wall of the sampling tube body.
Further preferably, one side of the bottle body is printed with scale marks, and the other side of the bottle body is provided with a label.
Further preferably, the bottle body and the cap are made of polytetrafluoroethylene.
Further preferably, the sealing cap is made of butyl rubber or natural rubber, and is in plug-in sealing connection with the bottle body.
Further preferably, the blood collection tube and the exhaust tube are arranged in parallel, and the bottom end of the exhaust tube penetrates through the sealing cap and extends to the bottom of the inner wall of the exhaust tube.
(III) advantageous effects
The invention provides a blood collection bottle for blood collection in immune cell therapy, which has the following beneficial effects:
(1) when needing sample analysis, utilize external syringe and first check valve to cooperate and be connected, carry out slow bleeding to the bottle inside, plasma in the exhaust duct is because of pressure variation, the liquid level rises thereupon, when plasma rises to the junction with the heparin tube, plasma receives in the gravity guide flow direction heparin tube, inject gas to the exhaust duct with syringe reverse propulsion this moment, make the plasma liquid level decline in it, and connect the plasma extraction of second check valve in with it through another syringe cooperation and detect, this operation process is gone on in sealed bottle, can not cause the plasma pollution in the bottle, be convenient for carry out many times inspection, the practicality is higher.
(2) Blood sampling is carried out through the external blood taking needle, conveniently accomplishes and abandons it after this operation, avoids the medical accident that multiple contact blood taking needle probably takes place, improves the degree of safety in utilization, and through the cooperation of block and bottle, can seal blood sampling mechanism, avoids producing the pollution on the way of the transportation.
(3) The existing bottle body, cap and blood sampling tube have simple structure and convenient use, are made of polytetrafluoroethylene, have the advantages of good biological safety, simple processing, low cost and the like, have higher practicability and are convenient for quantitative production;
(4) the sampling pipe and the exhaust pipe which are butted in a Bu-shaped mode enable pollution-free sampling to be achieved, and meanwhile multi-specification quantitative collection can be achieved through the magnetic ring.
Drawings
FIG. 1 is a front cross-sectional view of a structure of the present invention;
FIG. 2 is an enlarged view of the invention at A in FIG. 1;
FIG. 3 is a top cross-sectional view of a seal cap of the present invention.
In the figure: 1. a bottle body; 2. a blood collection mechanism; 201. a sealing cap; 202. a blood collection tube; 203. an exhaust pipe; 204. a sampling tube; 205. a luer fitting; 206. a first check valve; 207. a second one-way valve; 3. capping; 4. a limiting bulge; 5. a positioning groove.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-3, the present invention provides a technical solution: the utility model provides an immune cell therapy blood sampling is with heparin bottle, includes bottle 1, and the top of bottle 1 is pegged graft and is had blood sampling mechanism 2, and the top overlap joint of bottle 1 has block 3, and block 3 activity cup joints in the periphery of blood sampling mechanism 2, and spacing arch 4 has been seted up to the outer wall of bottle 1, and positioning groove 5 has been seted up at the edge of block 3 bottom, and spacing arch 4 joint is in positioning groove 5.
In the invention, the blood sampling mechanism 2 comprises a sealing cap 201, the sealing cap 201 is inserted at the top of the bottle body 1, a blood sampling tube 202, an exhaust tube 203 and a sampling tube 204 are fixedly inserted in the sealing cap 201, the top end of the sampling tube 204 penetrates through the exhaust tube 203 and is communicated with the inside of the exhaust tube, and one end of the blood sampling tube 202, one end of the exhaust tube 203 and one end of the sampling tube 204 are respectively and fixedly connected with a luer connector 205, a first one-way valve 206 and a second one-way valve 207 which are communicated with the inside of the blood sampling tube.
Wherein blast pipe 203 is greater than heparin tube 202 at bottle 1 internal submergence extension degree of depth, is provided with an interior slip ring at sampling pipe 204 body inner wall, and this interior slip ring comprises an interior magnetic ring and the rubber body of cladding in this interior magnetic ring outside, overlaps at sampling pipe 204 body outer wall and is equipped with an outer magnetic ring.
In the invention, scale marks are printed on one side of the bottle body 1, a label is arranged on the other side of the bottle body 1, and the interior of the bottle body 1 is in a vacuum state.
In the invention, the bottle body 1 and the cap 3 are made of polytetrafluoroethylene which is tough and elastic, is not easy to break like glass, has good chemical inertia and biological safety, has high plasticity and can be made into products with complex structures.
In the invention, one ends of the luer connector 205, the first one-way valve 206 and the second one-way valve 207, which are far away from the bottle body 1, are fixedly connected with syringe connectors communicated with the interior of the luer connector, the other ends of the syringe connectors are sleeved with sealing protective covers, the arrangement of the syringe connectors is convenient for connecting blood taking needles, connecting pipes, syringes and the like, and the flexible operation of medical staff is convenient.
In the present invention, the sealing cap 201 is made of butyl rubber or natural rubber, and is connected with the bottle body 1 in a sealing manner.
In the present invention, the blood collection tube 202 and the exhaust tube 203 are arranged in parallel, and the bottom end of the exhaust tube 203 penetrates the sealing cap 201 and extends to the bottom of the inner wall thereof.
In the invention, the sampling tube 204 is obliquely arranged on one side of the exhaust tube 203 and has a Chinese character 'bo' structure, and the bottom end of the sampling tube 204 is fixedly connected with the second one-way valve 207 and communicated with the interior of the second one-way valve.
When the invention needs sampling analysis, an external injector is matched and connected with the first one-way valve 206, the interior of the bottle body 1 is slowly pumped, the liquid level of the plasma in the exhaust pipe 203 rises along with the pressure change, when the plasma rises to the joint of the blood sampling pipe 202, the plasma is guided by gravity to flow into the blood sampling pipe 202, at the moment, the injector is reversely pushed to inject gas into the exhaust pipe 203, the liquid level of the plasma in the exhaust pipe is reduced, and the plasma in the exhaust pipe is extracted and detected through the other injector matched and connected with the second one-way valve 207, the operation process is carried out in the sealed bottle body 1, the plasma pollution in the bottle body 1 is not caused, multiple times of detection are convenient, the practicability is higher, the blood is sampled through the external blood sampling needle, the operation is convenient to discard after being finished, the medical accidents possibly caused by multiple times of contacting with the blood sampling needle are avoided, and the use safety, and through the cooperation of block 3 and bottle 1, can seal blood sampling mechanism 2, avoid producing the pollution on the way of the transportation, present bottle 1, block 3 and heparin tube 202 class simple structure convenient to use adopt polytetrafluoroethylene preparation, have good biosafety and the simple cost of processing advantage such as with low costs, the higher quantization production of being convenient for of practicality.
The working principle is as follows: firstly, according to the current target sampling amount, the external magnetic ring is held to slide on the sampling tube 204, so as to drive the internal sliding ring inside the sampling tube 204 to slide, so as to adjust the distance between the internal sliding ring and the junction of the exhaust tube 203 and the sampling tube 204, so as to adjust the current sampling amount, blood sampling is carried out by externally connecting a blood sampling needle through a luer connector 205, the blood sampling needle is discarded after the operation is finished, a cap 3 is covered on the upper half end of the bottle body 1, so that a limiting bulge 4 and a positioning groove 5 are clamped, when sampling analysis is needed, the cap 3 is opened, a syringe is matched and connected with a first one-way valve 206, air is slowly pumped inside the bottle body 1, the liquid level of plasma in the exhaust tube 203 rises along with the pressure change, when the plasma rises to the junction with the blood sampling tube 202, the plasma is guided by gravity to flow into the sampling tube 204, at the moment, the syringe is reversely pushed, make the plasma liquid level decline in it to connect the plasma extraction of second check valve 207 in with it through another syringe cooperation and detect, repeat above-mentioned step when needing to take a sample again can, above-mentioned in-process is through pumping repeatedly in first check valve 206 and inflating, make the blood sample of bottle 1 can enter into sampling tube 204 with a lot of ration, thereby realize being connected to the syringe in second check valve 207 and can with the blood separation in whole bottle 1, further reduce the possibility of pollution, in addition the slidable design of outer magnetic ring, make the convenient adjustment of current sample volume.
Claims (4)
1. The utility model provides an immune cell treatment blood sampling is with blood bottle, includes bottle (1), its characterized in that: the blood sampling bottle is characterized in that a blood sampling mechanism (2) is inserted into the top end of the bottle body (1), a cap (3) is lapped on the top of the bottle body (1), the cap (3) is movably sleeved on the periphery of the blood sampling mechanism (2), a limiting bulge (4) is formed in the outer wall of the bottle body (1), a positioning groove (5) is formed in the edge of the bottom end of the cap (3), and the limiting bulge (4) is clamped in the positioning groove (5);
the blood sampling mechanism (2) comprises a sealing cap (201), the sealing cap (201) is inserted at the top of the bottle body (1), a blood sampling tube (202), an exhaust tube (203) and a sampling tube (204) are fixedly inserted in the sealing cap (201), the top end of the sampling tube (204) penetrates through the exhaust tube (203) and is communicated with the inside of the exhaust tube, one ends of the blood sampling tube (202), the exhaust tube (203) and the sampling tube (204) are respectively and fixedly connected with a luer connector (205), a first one-way valve (206) and a second one-way valve (207) which are communicated with the inside of the blood sampling tube, one ends, far away from the bottle body (1), of the luer connector (205), the first one-way valve (206) and the second one-way valve (207) are respectively and fixedly connected with an injector connector which is communicated with the inside of the blood sampling tube, the other ends of the injector connectors are respectively sleeved with a sealing protective cover, the bottom end of the exhaust pipe (203) penetrates through the sealing cap (201) and extends to the bottom of the inner wall of the exhaust pipe, the sampling pipe (204) is obliquely arranged on one side of the exhaust pipe (203) and is of a Buck-shaped structure, and the bottom end of the sampling pipe (204) is fixedly connected with the second one-way valve (207) and communicated with the interior of the second one-way valve;
wherein blast pipe (203) dive in bottle (1) and extend the degree of depth and be greater than heparin tube (202), be provided with an interior slip ring at sampling tube (204) body inner wall, this interior slip ring comprises an interior magnetic ring and the cladding in the outside rubber body of this interior magnetic ring, overlaps at sampling tube (204) body outer wall and is equipped with an outer magnetic ring.
2. A blood collection bottle for immune cell therapy blood collection according to claim 1, characterized in that: scale marks are printed on one side of the bottle body (1), and a label is arranged on the other side of the bottle body (1).
3. A blood collection bottle for immune cell therapy blood collection according to claim 1, characterized in that: the bottle body (1) and the cap (3) are made of polytetrafluoroethylene.
4. A blood collection bottle for immune cell therapy blood collection according to claim 2, characterized in that: the sealing cap (201) is made of butyl rubber or natural rubber and is in plug-in type sealing connection with the bottle body (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110038533.9A CN112842336B (en) | 2021-01-12 | 2021-01-12 | Blood collecting bottle for blood collection in immune cell treatment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110038533.9A CN112842336B (en) | 2021-01-12 | 2021-01-12 | Blood collecting bottle for blood collection in immune cell treatment |
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| Publication Number | Publication Date |
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| CN112842336A true CN112842336A (en) | 2021-05-28 |
| CN112842336B CN112842336B (en) | 2023-01-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202110038533.9A Active CN112842336B (en) | 2021-01-12 | 2021-01-12 | Blood collecting bottle for blood collection in immune cell treatment |
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Citations (18)
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| JPH01288235A (en) * | 1988-05-17 | 1989-11-20 | Terumo Corp | Blood collector capable of setting/storing blood collecting quantity |
| CN2251972Y (en) * | 1995-12-07 | 1997-04-16 | 白杰 | Totally-enclosed negative pressure hemostix |
| JPH11290297A (en) * | 1998-04-08 | 1999-10-26 | Ai Design:Kk | Blood sampling tube |
| CN2618563Y (en) * | 2003-05-28 | 2004-06-02 | 泰尔茂医疗产品(杭州)有限公司 | Safety portable hemostix |
| EP1471337A2 (en) * | 2003-04-26 | 2004-10-27 | GOK Regler- und Armaturen-Gesellschaft mbH & Co.KG | Device for measuring the level of a liquid in a container |
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| CN207694830U (en) * | 2017-11-30 | 2018-08-07 | 惠州市润道检测技术有限公司 | A kind of reagent bottle |
| CN207823053U (en) * | 2017-12-28 | 2018-09-07 | 广东微碳检测科技有限公司 | It can prevent the novel liquid-transfering device of leakage splash |
| CN209123015U (en) * | 2018-09-21 | 2019-07-19 | 河南省人民医院 | A simple and sampleable negative pressure drainage bag |
| CN209186726U (en) * | 2018-08-06 | 2019-08-02 | 何晓伟 | A kind of one hand push type negative pressure blood collection needle tubing |
| CN210090098U (en) * | 2019-06-28 | 2020-02-18 | 河南省食品药品检验所 | Liquid medicine quantitative sampling device |
| CN211460233U (en) * | 2019-10-17 | 2020-09-11 | 天津科德生物科技有限公司 | Blood sampling device for immune cell therapy |
| CN211636571U (en) * | 2019-12-30 | 2020-10-09 | 南京弘口科学仪器有限公司 | Pipette capable of accurately and quantitatively transferring liquid |
| CN211796521U (en) * | 2020-03-09 | 2020-10-30 | 金华市中心医院 | a blood collector |
| CN211911632U (en) * | 2019-10-29 | 2020-11-13 | 刘逵 | Blood collector for clinical laboratory |
| CN111991008A (en) * | 2020-09-28 | 2020-11-27 | 无锡市第二人民医院 | Automatic blood sampling system and method of using the same |
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2021
- 2021-01-12 CN CN202110038533.9A patent/CN112842336B/en active Active
Patent Citations (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01288235A (en) * | 1988-05-17 | 1989-11-20 | Terumo Corp | Blood collector capable of setting/storing blood collecting quantity |
| CN2251972Y (en) * | 1995-12-07 | 1997-04-16 | 白杰 | Totally-enclosed negative pressure hemostix |
| JPH11290297A (en) * | 1998-04-08 | 1999-10-26 | Ai Design:Kk | Blood sampling tube |
| EP1471337A2 (en) * | 2003-04-26 | 2004-10-27 | GOK Regler- und Armaturen-Gesellschaft mbH & Co.KG | Device for measuring the level of a liquid in a container |
| CN2618563Y (en) * | 2003-05-28 | 2004-06-02 | 泰尔茂医疗产品(杭州)有限公司 | Safety portable hemostix |
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| CN205433714U (en) * | 2015-12-31 | 2016-08-10 | 深圳市第二人民医院 | Blood collecting bottle is used in autologous immune cell treatment blood sampling |
| CN207694830U (en) * | 2017-11-30 | 2018-08-07 | 惠州市润道检测技术有限公司 | A kind of reagent bottle |
| CN207823053U (en) * | 2017-12-28 | 2018-09-07 | 广东微碳检测科技有限公司 | It can prevent the novel liquid-transfering device of leakage splash |
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| CN210090098U (en) * | 2019-06-28 | 2020-02-18 | 河南省食品药品检验所 | Liquid medicine quantitative sampling device |
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| CN211911632U (en) * | 2019-10-29 | 2020-11-13 | 刘逵 | Blood collector for clinical laboratory |
| CN211636571U (en) * | 2019-12-30 | 2020-10-09 | 南京弘口科学仪器有限公司 | Pipette capable of accurately and quantitatively transferring liquid |
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| Publication number | Publication date |
|---|---|
| CN112842336B (en) | 2023-01-17 |
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