CN112812202A - Heparin crude production system of processing - Google Patents
Heparin crude production system of processing Download PDFInfo
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- CN112812202A CN112812202A CN202011577382.6A CN202011577382A CN112812202A CN 112812202 A CN112812202 A CN 112812202A CN 202011577382 A CN202011577382 A CN 202011577382A CN 112812202 A CN112812202 A CN 112812202A
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
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Abstract
The invention discloses a heparin crude product production and processing system, wherein the heights of a water inlet of a cooling tower, a water outlet of the cooling tower and a cold water inlet of an intestine scraper are sequentially reduced, the heights of a water inlet of a water storage cavity, a water outlet of the water storage cavity and a hot water inlet of the intestine scraper are sequentially reduced, the heights of the cold water inlet and the hot water inlet of the intestine scraper are higher than those of a discharge hole of the intestine scraper, the heights of a discharge hole of a mucosa pool, a discharge hole of the mucosa pool, a feed hole of a treatment cavity, a discharge hole of the treatment cavity, a feed hole of an adsorption cavity, a discharge hole of the adsorption cavity, a feed hole of a wastewater pool and a discharge hole of the wastewater pool are sequentially reduced, and a water inlet of a cooling sleeve is lower than the water outlet of the cooling tower. The heparin crude product production and processing system can effectively reduce the overall energy consumption and the operation cost of the heparin crude product production and processing system.
Description
Technical Field
The invention relates to the technical field of heparin crude product production and processing, in particular to a heparin crude product production and processing system.
Background
Heparin, as an anticoagulant, is a polymer formed by alternately connecting two polysaccharides and has anticoagulant effects both inside and outside the body. Heparin is widely present in tissues such as lungs, vessel walls, intestinal mucosa and the like of animals, is a natural anticoagulant substance in animal bodies, is naturally present in mast cells, and is currently mainly extracted from lung or small intestinal mucosa of livestock such as cows, pigs and the like. The heparin is mainly used for thromboembolic diseases, myocardial infarction, cardiovascular operations, cardiac catheter examination, extracorporeal circulation, hemodialysis and the like clinically. With the progress of pharmacology and clinical medicine, the application of heparin is continuously expanding.
At present, extraction and production processing of heparin are generally carried out in a factory, but are limited by the existing factory scale and factory environment arrangement, the existing heparin production processing factory area is generally arranged on a flat ground, liquid conveying in each pipeline related to a production processing system is generally realized through pumping, so that the dependence on pump parts during factory production and processing is higher, and the pump parts are generally driven by electric power, so that the energy consumption of the whole factory and the production system is higher, and the production cost is higher.
Therefore, how to reduce the energy consumption and the operation cost of the heparin crude product production and processing system is an important technical problem to be solved by the technical personnel in the field at present.
Disclosure of Invention
The invention aims to provide a heparin crude product production and processing system which can effectively reduce the overall energy consumption and the operation cost of the heparin crude product production and processing system.
In order to solve the technical problems, the invention provides a heparin crude product production and processing system, which comprises a hot water tower and a cold water tower communicated with an off-plant tap water pipe network, wherein a heating cavity communicated with off-plant industrial steam supply equipment and a water storage cavity communicated with the off-plant tap water pipe network are arranged in the hot water tower, the heparin crude product production and processing system also comprises an intestine scraper communicated with off-plant small intestine material supply equipment, a cold water inlet communicated with a water outlet of the cold water tower and a hot water inlet communicated with a water outlet of the water storage cavity are also connected to the intestine scraper, a feed inlet of a mucosa pool is connected to the downstream of a discharge port of the intestine scraper, an enzymolysis tank is arranged at the downstream of the mucosa pool, a steam cavity communicated with the off-plant industrial steam supply equipment and a processing cavity communicated with the mucosa pool are arranged in the enzymolysis tank, and the feed inlet of the processing cavity is communicated with the discharge port of the, an adsorption tank is arranged at the downstream of the enzymolysis tank, an adsorption cavity communicated with the treatment cavity and a cooling sleeve communicated with a water outlet of the cooling water tower are arranged in the adsorption tank, a feed inlet of the adsorption cavity is communicated with a discharge outlet of the treatment cavity, a wastewater pond is connected at the downstream of a discharge outlet of the adsorption cavity, a feed inlet of the wastewater pond is communicated with a discharge outlet of the adsorption cavity, and a discharge outlet of the wastewater pond is communicated with an off-plant wastewater pipe network;
the water inlet of cold water tower, the delivery port of this cold water tower scrape the highly reducing in proper order of the cold water import of intestines machine, the water inlet in retaining chamber, the delivery port in this retaining chamber scrape the highly reducing in proper order of the hot water import of intestines machine, the cold water import of scraping the intestines machine and its hot water import all are higher than its discharge gate, scrape the discharge gate of intestines machine the feed inlet in mucosa pond, the discharge gate in this mucosa pond the feed inlet in treatment chamber, the bin outlet in this treatment chamber the feed inlet in absorption chamber, the bin outlet in this absorption chamber the feed inlet in wastewater disposal pond and the bin outlet of this wastewater pond highly reduce in proper order, cooling jacket's water inlet is less than the delivery port of cold water tower.
Preferably, a hot water return pipe is communicated between the water outlet of the cooling sleeve and the hot water tower, and a return pump for enabling water flow to flow from the cooling sleeve to the hot water tower is arranged on the hot water return pipe.
Preferably, the cold water tower, the hot water tower, the intestine scraper, the mucous membrane tank, the enzymolysis tank, the adsorption tank and the wastewater tank are uniformly distributed on the same slope surface or a continuous step surface.
Preferably, the heights of the cold water tower and the hot water tower are the same, and the hot water tower, the intestine scraper, the mucosa tank, the enzymolysis tank, the adsorption tank and the wastewater tank are sequentially arranged from high to low.
Preferably, the fall between the top and the bottom of the slope is not less than 12 m.
Preferably, the difference between the discharge port of the intestine scraper and the feed inlet of the mucous membrane pool is not less than 2 meters, the difference between the discharge port of the mucous membrane pool and the feed inlet of the treatment cavity is not less than 4 meters, and the difference between the discharge port of the treatment cavity and the feed inlet of the adsorption cavity is not less than 4 meters.
Preferably, a liquid level monitoring device and an alarm device matched with the liquid level monitoring device are arranged in the cold water tower and the hot water tower.
Preferably, an automatic temperature control device is arranged in the water storage cavity.
Compared with the background art, when the heparin crude product production and processing system provided by the invention works and operates, the working devices arranged from high to low fall are cooperated, so that liquid materials in each pipeline can sequentially flow through the working devices under the action of self weight, and the material conveying can be realized without arranging pump parts in the whole system, thereby greatly reducing the energy consumption of the whole system, reducing the corresponding maintenance work intensity of workers, optimizing the layout of each device and equipment, improving the work efficiency of the whole heparin crude product production and processing system, and correspondingly reducing the whole operation cost.
In another preferred embodiment of the present application, a hot water return pipe is communicated between the water outlet of the cooling jacket and the hot water tower, and a return pump is disposed on the hot water return pipe and allows water to flow from the cooling jacket to the hot water tower. The cold water in the cooling jacket becomes hot water after accomplishing and adsorbing the heat exchange between the intracavity material, later through the cooperation between backwash pump and hot water return pipe, carries the hot water in the cooling jacket to the retaining intracavity of hot-water tower to with the high-efficient recycle of hot water in the cooling jacket, avoid the wasting of resources, further reduced heparin crude production and processing system's running cost.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a schematic structural diagram of a heparin crude product production processing system according to an embodiment of the present invention.
Wherein, 11-hot water tower, 12-cold water tower, 13-intestine scraper, 14-mucous membrane pool, 15-enzymolysis tank, 151-steam cavity, 152-processing cavity, 16-adsorption tank, 161-adsorption cavity, 162-cooling sleeve, 17-waste water pool, 18-hot water return pipe, 181-reflux pump, 21-tap water network outside plant, 22-industrial steam supply equipment outside plant, 23-small intestine material supply equipment outside plant, 24-waste water network outside plant.
Detailed Description
The core of the invention is to provide a heparin crude product production and processing system, which can effectively reduce the overall energy consumption and the operation cost of the heparin crude product production and processing system.
In order that those skilled in the art will better understand the disclosure, the invention will be described in further detail with reference to the accompanying drawings and specific embodiments.
Referring to fig. 1, fig. 1 is a schematic structural diagram of a heparin crude product production processing system according to an embodiment of the present invention.
In a specific embodiment, the heparin crude product production and processing system provided by the invention comprises a hot water tower 11 and a cold water tower 12 communicated with an off-plant tap water pipe network 21, wherein a heating cavity communicated with an off-plant industrial steam supply device 22 and a water storage cavity communicated with the off-plant tap water pipe network 21 are arranged in the hot water tower 11, the hot water tower 13 further comprises a intestine scraper 13 communicated with an off-plant small intestine material supply device 23, the intestine scraper 13 is also connected with a cold water inlet communicated with a water outlet of the cold water tower 12 and a hot water inlet communicated with a water outlet of the water storage cavity, a feed port of a mucous membrane pool 14 is connected with the downstream of a discharge port of the intestine scraper 13, an enzymolysis tank 15 is arranged at the downstream of the mucous membrane pool 14, a steam cavity 151 communicated with the off-plant industrial steam supply device 22 and a treatment cavity 152 communicated with the mucous membrane pool 14 are arranged in the enzymolysis tank 15, the feed port of the treatment cavity 152 is communicated with the discharge port of, an adsorption tank 16 is arranged at the downstream of the enzymolysis tank 15, an adsorption chamber 161 communicated with the treatment chamber 152 and a cooling sleeve 162 communicated with the water outlet of the cold water tower 12 are arranged in the adsorption tank 16, a feed inlet of the adsorption chamber 161 is communicated with a discharge outlet of the treatment chamber 152, a waste water pool 17 is connected at the downstream of a discharge outlet of the adsorption chamber 161, a feed inlet of the waste water pool 17 is communicated with a discharge outlet of the adsorption chamber 161, and a discharge outlet of the waste water pool 17 is communicated with an off-plant waste water pipe network 24; the heights of the water inlet of the cooling water tower 12, the water outlet of the cooling water tower 12 and the cold water inlet of the intestine scraper 13 are sequentially reduced, the heights of the water inlet of the water storage cavity, the water outlet of the water storage cavity and the hot water inlet of the intestine scraper 13 are sequentially reduced, the cold water inlet and the hot water inlet of the intestine scraper 13 are higher than the water outlet of the intestine scraper, the discharge hole of the intestine scraper 13, the feed hole of the mucosa pool 14, the discharge hole of the mucosa pool 14, the feed hole of the treatment cavity 152, the discharge hole of the treatment cavity 152, the feed hole of the adsorption cavity 161, the discharge hole of the adsorption cavity 161, the feed hole of the wastewater pool 17 and the discharge hole of the wastewater pool 17 are sequentially reduced, and the water inlet of the cooling sleeve 162 is lower than the water outlet of the.
During the operation, tap water from the tap water network 21 outside the plant is respectively introduced into the cooling tower 12 and the water storage cavity and accumulated, high-temperature steam from the industrial steam supply device 22 outside the plant is introduced into the heating cavity to heat water in the water storage cavity, after the water temperature in the water storage cavity is raised to a proper temperature, a proper amount of cold water and hot water are synchronously injected into the intestine scraper 13 through the cooling tower 12 and the water storage cavity to form a warm water environment, small intestine materials are conveyed into the intestine scraper 13 through the small intestine material supply device 23 outside the plant for scraping treatment so as to scrape mucosa off the small intestine, the scraped mucosa is mixed in the warm water to form a mixed solution, the mixed solution is sequentially introduced into the mucosa tank 14 through the discharge port of the intestine scraper 13 and the feed port of the mucosa tank 14 to be accumulated, then is conveyed into the treatment cavity 152 through the mucosa tank 14, and the high-temperature steam from the industrial steam supply device 22 outside the plant is introduced into the steam cavity 151, thereby utilize the heat exchange of the interior high temperature steam of steam chamber 151 and the interior mixed liquid of treatment chamber 152, promote the mucosa in the mixed liquid to take place the enzymolysis, enzymolysis liquid after the enzymolysis is gone into and adsorbs the processing in being absorbed chamber 161, cold water is let into in cooling jacket 162 and carry out the heat exchange with absorption chamber 161 and inside enzymolysis liquid etc. by cold water tower 12 simultaneously, in order to reduce the ambient temperature and the material temperature in the absorption chamber 161, guarantee the adsorption effect, the absorption raffinate that forms after the absorption processing is discharged into wastewater disposal basin 17, and finally discharge to the waste water network 24 of factory outside through the bin outlet of wastewater disposal basin 17 and concentrate the processing.
Above-mentioned production and processing system is through each equipment cooperateing by high to low head arrangement, make water in each pipeline and the device, mix each equipment that flows through in proper order under the dead weight effect, liquid materials such as enzymolysis liquid and absorption raffinate can realize the material transport in the entire system without arranging pump class part, whole system's energy consumption has been reduced by a wide margin, the corresponding maintenance work intensity of staff has been reduced, the overall arrangement of each device and equipment has been optimized, whole heparin crude product production and processing system's work efficiency has been improved, and make its whole running cost can correspondingly reduce.
Furthermore, a hot water return pipe 18 is connected between the water outlet of the cooling jacket 162 and the hot water tower 11, and a return pump 181 for causing water to flow from the cooling jacket 162 to the hot water tower 11 is provided in the hot water return pipe 18. The cold water in the cooling sleeve 162 becomes hot water after finishing heat exchange with the materials in the adsorption cavity 161, and then the hot water in the cooling sleeve 162 is conveyed to the water storage cavity of the hot water tower 11 through the cooperation between the reflux pump 181 and the hot water reflux pipe 18, so that the hot water in the cooling sleeve 162 is efficiently recycled, the resource waste is avoided, and the operation cost of the heparin crude product production and processing system is further reduced.
Specifically, a cold water tower 12, a hot water tower 11, a intestine scraper 13, a mucous membrane tank 14, an enzymolysis tank 15, an adsorption tank 16 and a wastewater tank 17 are uniformly distributed on the same slope surface or a continuous step surface. In consideration of actual plant layout and construction cost, all devices and equipment of the heparin crude product production and processing system are preferably arranged on a sloping field, so that the sloping field structure can be utilized according to local conditions to naturally form fall between all matching devices and equipment, and pipelines are correspondingly arranged to ensure that liquid materials can naturally flow between all relevant devices and equipment by means of self weight and ensure stable operation of all devices and equipment, so that the topographic advantages and natural resources are fully utilized, and the overall construction and operation cost of the heparin crude product production and processing system is greatly reduced.
It should be noted that if continuous step surface arrangement is adopted, support tables or supports with different heights need to be correspondingly arranged to ensure arrangement and installation of all devices and equipment, and for a factory without sloping field conditions, the arrangement can easily realize a fall arrangement structure, so that stable and efficient operation of the whole production and processing system is ensured.
More specifically, the cold water tower 12 and the hot water tower 11 are the same in height, and the hot water tower 11, the intestine scraper 13, the mucosa tank 14, the enzymolysis tank 15, the adsorption tank 16 and the wastewater tank 17 are arranged in sequence from high to low. The cold water tower 12 and the hot water tower 11 are arranged in equal height, so that the water supply pressure of the cold water tower 12 and the water storage cavity can be approximate, and the stable operation of related downstream equipment is facilitated. Of course, the heights of the cold water tower 12 and the hot water tower 11 may be different according to different specific working conditions, and in practical application, a worker may flexibly adjust the heights according to specific working conditions, as long as the actual operation requirements of the heparin crude product production and processing system can be met.
In addition, the fall of the top and the bottom of the slope is not less than 12 meters. The fall value can meet the requirements of material conveying and equipment operation under most conditions. Of course, in consideration of the actual plant environment and working condition, the value of the fall can be flexibly adjusted according to the actual situation, and in principle, the stable working operation of each device and apparatus of the heparin crude product production and processing system can be ensured.
On the basis, the fall between the discharge hole of the intestine scraper 13 and the feed hole of the mucosa pool 14 is not less than 2 meters, the fall between the discharge hole of the mucosa pool 14 and the feed hole of the treatment cavity 152 is not less than 4 meters, and the fall between the discharge hole of the treatment cavity 152 and the feed hole of the adsorption cavity 161 is not less than 4 meters. Similar to the total fall value, the adaptive falls between the devices can be flexibly adjusted according to the actual working condition environment, so as to meet the specific working operation requirement of the heparin crude product production and processing system.
It should be understood that, unless otherwise specified, the references to "upstream" and "downstream" are made with reference to the material conveying direction, i.e., upstream and downstream along the material conveying direction, and the description of the rest of the text relating to "upstream" and "downstream" is understood with reference to the references and will not be repeated.
On the other hand, liquid level monitoring devices and alarm devices matched with the liquid level monitoring devices are arranged in the cold water tower 12 and the hot water tower 11. Taking the actual operation situation as an example, the design heights of the water cooling tower 12 and the water storage cavity can be set to be 2 meters, the designed maximum water capacity is 100 tons, correspondingly, the minimum monitoring water level of the liquid level monitoring device is 30 tons, the upper limit water level of the water supplement is 60 tons, and the warning water level is 90 tons, namely, when the water storage amount in the water cooling tower 12 or the water storage cavity is less than 30 tons, the water is automatically supplemented to 60 tons from the tap water pipe network 21 outside the plant, if the water storage amount in the water cooling tower 12 or the water storage cavity is more than 90 tons, an alarm device gives an alarm to inform a worker to timely control the water storage amounts in the water cooling tower 12 and the water storage cavity, so that the overload operation of equipment or the water overflow is avoided, and the stable operation of the heparin crude product.
In addition, an automatic temperature control device is arranged in the water storage cavity. Taking the actual operation condition as an example, the monitoring temperature of the automatic temperature control device can be set to 60 degrees, namely, when the temperature of the water body in the water storage cavity exceeds 60 degrees, the automatic temperature control device can prevent high-temperature steam from continuously entering the heating cavity through the electric control valve or other types of pipeline control devices, if the steam blocking control mode fails to prevent the water temperature in the water storage cavity from continuously rising, the automatic temperature control device can give an alarm to inform workers to timely check and maintain the working states of the automatic temperature control device and the corresponding electric control valves and other devices, troubleshoot the corresponding devices and timely carry out overhaul and maintenance, and timely disconnect the supply of the high-temperature steam through manual operation when necessary, thereby avoiding the adverse effect on the stable operation of downstream equipment and pipelines due to overhigh water temperature in the water storage cavity.
In summary, when the heparin crude product production and processing system provided by the invention works, the working devices arranged from high to low fall are cooperatively matched, so that liquid materials in the pipelines can sequentially flow through the working devices under the action of self weight, and the material conveying can be realized without arranging pump parts in the whole system, thereby greatly reducing the energy consumption of the whole system, reducing the corresponding maintenance work intensity of workers, optimizing the layout of the devices and equipment, improving the work efficiency of the whole heparin crude product production and processing system, and correspondingly reducing the whole operation cost.
The heparin crude product production and processing system provided by the invention is described in detail above. The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
Claims (8)
1. The heparin crude product production and processing system is characterized by comprising a hot water tower and a cold water tower communicated with a tap water pipe network outside a plant, wherein the hot water tower is internally provided with a heating cavity communicated with industrial steam supply equipment outside the plant and a water storage cavity communicated with the tap water pipe network outside the plant, the heparin crude product production and processing system further comprises an intestine scraper communicated with small intestine material supply equipment outside the plant, the intestine scraper is also connected with a cold water inlet communicated with a water outlet of the cold water tower and a hot water inlet communicated with a water outlet of the water storage cavity, the downstream of a discharge hole of the intestine scraper is connected with a feed inlet of a mucosa pool, the downstream of the mucosa pool is provided with an enzymolysis tank, the inside of the enzymolysis tank is provided with a steam cavity communicated with industrial steam supply equipment outside the plant and a processing cavity communicated with the mucosa pool, the feed inlet of the processing cavity is communicated with the discharge hole of the mucosa pool, the downstream of the enzymolysis tank is provided with, an adsorption cavity communicated with the treatment cavity and a cooling sleeve communicated with a water outlet of the cooling water tower are arranged in the adsorption tank, a feed inlet of the adsorption cavity is communicated with a discharge outlet of the treatment cavity, a wastewater pond is connected to the downstream of a discharge outlet of the adsorption cavity, a feed inlet of the wastewater pond is communicated with a discharge outlet of the adsorption cavity, and a discharge outlet of the wastewater pond is communicated with an off-plant wastewater pipe network;
the water inlet of cold water tower, the delivery port of this cold water tower scrape the highly reducing in proper order of the cold water import of intestines machine, the water inlet in retaining chamber, the delivery port in this retaining chamber scrape the highly reducing in proper order of the hot water import of intestines machine, the cold water import of scraping the intestines machine and its hot water import all are higher than its discharge gate, scrape the discharge gate of intestines machine the feed inlet in mucosa pond, the discharge gate in this mucosa pond the feed inlet in treatment chamber, the bin outlet in this treatment chamber the feed inlet in absorption chamber, the bin outlet in this absorption chamber the feed inlet in wastewater disposal pond and the bin outlet of this wastewater pond highly reduce in proper order, cooling jacket's water inlet is less than the delivery port of cold water tower.
2. The heparin crude product production and processing system of claim 1, wherein a hot water return pipe is communicated between the water outlet of the cooling sleeve and the water storage cavity, and a return pump for enabling water to flow from the cooling sleeve to the water storage cavity is arranged on the hot water return pipe.
3. The heparin crude product production and processing system of claim 1, wherein the cold water tower, the hot water tower, the intestine scraper, the mucosa tank, the enzymolysis tank, the adsorption tank and the wastewater tank are all arranged on the same slope surface or on a continuous stepped surface.
4. The heparin crude product production and processing system of claim 3, wherein the height of the cold water tower is the same as that of the hot water tower, and the hot water tower, the intestine scraper, the mucosa tank, the enzymolysis tank, the adsorption tank and the wastewater tank are arranged in sequence from high to low.
5. The heparin crude product production and processing system of claim 3, wherein the difference between the top and the bottom of the slope is not less than 12 meters.
6. The heparin crude product production and processing system of claim 5, wherein the difference in height between the discharge port of the intestine scraper and the feed port of the mucous membrane tank is not less than 2 meters, the difference in height between the discharge port of the mucous membrane tank and the feed port of the treatment chamber is not less than 4 meters, and the difference in height between the discharge port of the treatment chamber and the feed port of the adsorption chamber is not less than 4 meters.
7. The heparin crude product production and processing system of claim 1, wherein a liquid level monitoring device and an alarm device matched with the liquid level monitoring device are arranged in each of the cold water tower and the hot water tower.
8. The heparin crude product production and processing system of claim 1, wherein an automatic temperature control device is arranged in the water storage cavity.
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| CN202011577382.6A CN112812202A (en) | 2020-12-28 | 2020-12-28 | Heparin crude production system of processing |
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| CN202011577382.6A CN112812202A (en) | 2020-12-28 | 2020-12-28 | Heparin crude production system of processing |
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| EP0021750A1 (en) * | 1979-06-15 | 1981-01-07 | Kureha Kagaku Kogyo Kabushiki Kaisha | Production of spherically shaped material made of chitin derivative |
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| EP0021750A1 (en) * | 1979-06-15 | 1981-01-07 | Kureha Kagaku Kogyo Kabushiki Kaisha | Production of spherically shaped material made of chitin derivative |
| US4987223A (en) * | 1981-12-23 | 1991-01-22 | Choay S.A. | Derivatives of the uronic acid |
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Application publication date: 20210518 |