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CN112789286A - 成骨生长肽碳端五肽衍生物及其制备方法和应用 - Google Patents

成骨生长肽碳端五肽衍生物及其制备方法和应用 Download PDF

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Publication number
CN112789286A
CN112789286A CN202080004195.0A CN202080004195A CN112789286A CN 112789286 A CN112789286 A CN 112789286A CN 202080004195 A CN202080004195 A CN 202080004195A CN 112789286 A CN112789286 A CN 112789286A
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gly
ogp
tyr
phe
fmoc
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CN202080004195.0A
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CN112789286B (zh
Inventor
张腾
张忠旗
郭添
刘少军
李晨召
李乾
王昕�
赵金礼
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Shaanxi HuiKang Bio Tech Co Ltd
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Shaanxi HuiKang Bio Tech Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)

Abstract

本发明提供一种成骨生长肽碳端五肽衍生物及其制备方法和应用。该成骨生长肽碳端五肽衍生物包括：H‑Dopa‑Gly‑Phe‑Gly‑Gly‑OH，H‑D‑Tyr‑Pro‑D‑Phe‑Gly‑Gly‑OH，Cyclo(Gly‑Gly‑D‑Phe‑Pro‑D‑Tyr)，Cyclo(Tyr‑Gly‑D‑Phe‑Gly‑Gly)，Cyclo(D‑Tyr‑Gly‑Phe‑Gly‑Gly)，Cyclo(Gly‑Gly‑D‑Phe‑Gly‑Tyr)，Cyclo(Gly‑Gly‑Phe‑Gly‑D‑Tyr)中的一种或多种。其在结构上保留了原有五肽的药效基团Tyr10和Phe12，具备改善代谢稳定性的结构特点。

Description

PCT国内申请，说明书已公开。

Claims (13)

  1. PCT国内申请，权利要求书已公开。
CN202080004195.0A 2019-09-06 2020-04-17 成骨生长肽碳端五肽衍生物及其制备方法和应用 Active CN112789286B (zh)

Applications Claiming Priority (3)

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CN201910841233 2019-09-06
CN2019108412337 2019-09-06
PCT/CN2020/085363 WO2021042732A1 (zh) 2019-09-06 2020-04-17 成骨生长肽碳端五肽衍生物及其制备方法和应用

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CN112789286B CN112789286B (zh) 2023-08-29

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1269242A (zh) * 1999-04-01 2000-10-11 上海医科大学附属中山医院 成骨生长肽药物组合物及制备方法和应用
US20030069175A1 (en) * 1996-03-10 2003-04-10 Itai Bab Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same
CN1737009A (zh) * 2004-08-17 2006-02-22 中国医学科学院药物研究所 多肽化合物及其医药用途
CN1785424A (zh) * 2004-12-09 2006-06-14 兰州大学 成骨生长五肽药物组合物及制备方法
CN103665109A (zh) * 2013-11-15 2014-03-26 陕西东大生化科技有限责任公司 成骨生长肽碳端五肽的合成方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030069175A1 (en) * 1996-03-10 2003-04-10 Itai Bab Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same
CN1269242A (zh) * 1999-04-01 2000-10-11 上海医科大学附属中山医院 成骨生长肽药物组合物及制备方法和应用
CN1737009A (zh) * 2004-08-17 2006-02-22 中国医学科学院药物研究所 多肽化合物及其医药用途
CN1785424A (zh) * 2004-12-09 2006-06-14 兰州大学 成骨生长五肽药物组合物及制备方法
CN103665109A (zh) * 2013-11-15 2014-03-26 陕西东大生化科技有限责任公司 成骨生长肽碳端五肽的合成方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ITAI BAB ET AL.: ""Osteogenic Growth Peptide:From Concept to Drug Design"", 《BIOPOLYMERS (PEPTIDE SCIENCE)》 *
YU-CHEN CHEN ET AL.: ""Bioactive Pseudopeptidic Analogues and Cyclostereoisomers of Osteogenic Growth Peptide C-Terminal Pentapeptide, OGP(10-14)"", 《JOURNAL OF MEDICINAL CHEMISTRY》 *
张腾 等: ""成骨生长肽的生物学特征及构效关系研究进展"", 《中国药物化学杂志》 *

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CN112789286B (zh) 2023-08-29

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