CN1127645A - Method for preparing medical Fructus phyllanthi capsule - Google Patents

Abstract

The phyllanthus emblica capsule for curing hyperlipemia, simple obesity and hypertension is prepared through extruding phyllanthus emblica to obtain juice, filtering, vacuum concentration, drying, granulating, capsulizing and package, and features various natural nutrients, trace elements and medical components phyllanthus emblica contains.

Description

The preparation method of medical Fructus phyllanthi capsule

The present invention relates to a kind of preparation method of medicine, particularly a kind of preparation method that is applicable to the medical Fructus phyllanthi capsule of hypertension, hyperlipemia and simple obesity treatment.

Medical Fructus phyllanthi capsule is to be that feedstock production forms pharmaceutical preparation with the Fructus Phyllanthi.Fructus Phyllanthi (Pnyllanlhus emblical) is a Radix Euphorbiae Pekinensis kind phyllanthus plant, extensively distributes in China south.Fructus Phyllanthi is as medicinal, origin for a long time, " the foreign body will " that poplar inspires confidence in before 1800 is done special the argumentation to it.All record the medicinal efficacy of emblic in Tang Materia Medica afterwards, the supplement to the Herbal Compendium of Material Medica.For example: put down in writing emblic " bitter but sweet flavor, cold, nontoxic, main air deficiency-heat gas in the Tang Materia Medica; " put down in writing emblic " main tonification, strong strength " in the supplement to the Herbal; The record emblic has the magical effect of " clothes are made light of one's life by commiting suicide for a long time, and it is long-living to prolong life " in the Compendium of Material Medica.Contain abundant multiple nutrients compositions such as vitamin C according to interrelated data report Phyllanthus emblica L., human body is had heat clearing away, detoxifcation, promoting digestion and invigorating the stomach, the cough-relieving of promoting the production of body fluid, blood fat-reducing blood pressure-decreasing, fat-reducing, anti-cancer, anticancer, health care many health-care effecies of waiting for a long time.Can be used for treating hypertension, hyperlipemia, hypercholesterolemia, obesity, and vitamin C and Vitamin PP deficiency disease.Phyllanthus emblica L. has very high medical value to human body, does not meet report yet utilize Phyllanthus emblica L. to make medicine as yet in order to treat some disease.

The object of the invention is to provide a kind of preparation method with medical Fructus phyllanthi capsule of Phyllanthus emblica L. nutrition and medical value.With emblic capsule taking convenience, the drug effect height that this method is made, processing technology is simple, have suitability for industrialized production to be worth.

According to the object of the invention, the disclosed medical Fructus phyllanthi capsule of inventor is to be raw material with the Sucus Phyllanthi, and technical process comprises: process such as emblic juice squeezes, filtration, vacuum concentration, drying, granulation, dress capsule, packing.Now concrete step of preparation process is described as follows:

One, emblic juice squeezes: select fresh, intact, sophisticated Phyllanthus emblica L., after the sterilization of 0.15% potassium permanganate solution, rinse well and airing with purifying waste water, with the broken enucleation of fruit, sarcocarp is squeezed the juice with disintegrating machine;

Two, filter: will squeeze emblic juice and install filtration after filtration, abandoning short, bristly hair or beard, to get emblic juice standby;

Three, vacuum concentration: will put the vacuum concentration pot concentration through filtering emblic juice, thickening temperature is controlled at 50-60 ℃, vacuum 650-720mmhg, and concentration 1.5-2 hours is that 12-18 Baume degrees (Brix) get final product to fruit juice concn;

Three, drying: this technology can be by following two steps:

1, spray drying method: add after 1-5% food starch of fruit juice amount or medical starch stir at above-mentioned Phyllanthus emblica L. juice through concentration, send the centrifugal spray drier spray drying to, inlet temperature is controlled at 125-150 ℃, and temperature of outgoing air is controlled at 70-80 ℃, and to obtain water content be emblic powder below 6%.

2, bake drying method: at above-mentioned food starch or the medical starch that in the emblic juice of concentration, adds fruit juice amount 1-5%, after stirring, place 60 ℃ of following temperature to dry water content below 9%, be ground into the emblic powder again.

Four, granulate: the emblic powder of above-mentioned preparation after 24 orders sieve, is added the magnesium stearate of 0.1-0.5% emblic juice amount, and mix homogeneously places 60 ℃ of following temperature to dry to water content below 7% above-mentioned emblic granule through granulating after granulator is granulated.

Six, dress capsule: the emblic medicine grain of above-mentioned drying is sent into the tire bagger fill in capsule, promptly make the medical Fructus phyllanthi capsule finished product.Dress 0.3g emblic powder in every capsules.

Seven, finished product packing: various manner of packings such as capsule finished product packing is can be bottled box-packed.

Controlling Phyllanthus emblica L. natural various nutritions and trace element owing to temperature is strict by the medical Fructus phyllanthi capsule of above-mentioned process preparation in its preparation technology does not have destroyed, keep the various nutritions and the trace element that contain Phyllanthus emblica L., belonging to pure natural medical.According to pharmacology teaching and research room of Fujian Medical College pharmacological evaluation and the toxicity research that medical Fructus phyllanthi capsule carries out shown: this medicine can reduce T-CHOL in the rat serum (TC), improve high density lipoprotein-cholesterol (content of HDL-C), strengthen erythrocyte and cerebral tissue SOD vigor, reduce serum and cerebral tissue lipid peroxide (LPO) content, also can reduce the weight of animals simultaneously and increase index.By testing clinically human body is obtained same effect.Toxicologic study mensuration through strictness shows that this medicine belongs to no cytotoxic drug.To emblic Drug Capsule medicinal efficacy, Affiliated Hospital of Fujian Medical College, the People's Hospital, Fujian Province, Fuzhou No.2 Hospital, Fujian Institute of Traditional Chinese Medicine etc. carry out phase ii clinical trial, and clinical research shows as follows:

One, took the emblic capsule one month through and overweight patient's 129 examples fat to simple pure property, every day three times, each 3-5, the obvious effective rate aggregate efficiency is respectively 24.47%, 85.19% average loss of weight 1.90 ± 1.23Kg, wherein maximum minimizing 5kg; On average dwindle waistline 2.4+2.22cm, wherein dwindle maximum 11.0cm that reaches.Show loss of weight and dwindle abdominal circumference and all be highly significant difference, PC0.001 by contrast before and after the treatment.Simultaneously, take patient and reflect that symptoms such as uncomfortable in chest, tachypnea, weak, abdominal distention, blood pressure are all to a certain degree alleviated.

Three, through the observation to hyperlipemia 379 examples, the obvious effective rate of a pair of hypertriglyceridemia, total effective rate divide other country 33.3%, 72.41%; To the obvious effective rate of hypercholesterolemia, total effective rate is respectively 27.69%, 70.16%.All be highly significant difference, p＜0.001 by contrast before and after the treatment.

Medical Fructus phyllanthi capsule is to digesting and appetizing, and the heat-clearing and toxic substances removing and the cough-relieving aspect effect of promoting the production of body fluid also show very obviously desirablely.

Below in conjunction with specific embodiment the present invention is further described.

Select anosis mashed ripe Phyllanthus emblica L. 1000Kg among the embodiment for use, sterilize with 0.15% potassium permanganate solution 50Kg, flushing drains with purifying waste water, use the crusher in crushing enucleation, sarcocarp is squeezed the juice, and filters waste with cottonseed cake, gets surplus juice honeydew 4000Kg, the potassium sorbate that adds fruit juice amount 0.3% is anticorrosion, and it is tightly standby to be sub-packed in the plastic drum lid of sterilizing.Getting 1250Kg emblic juice puts vacuum concentration pot and concentrates, thickening temperature is controlled at 60 ℃, vacuum 660mmHg when concentrating about 1.5 hours, reaches 18Brix to fruit juice concn, add the 5Kg medical starch, send centrifugal spray drying tower after stirring to and dust, 130 ℃ of tower top temperatures, temperature (exhaust outlet)＞70 ℃ in the tower, the pressure that dusts is controlled at 0.15mPa, and the water content of dusting is 3%.To make the emblic powder after screen cloth on the 24th sieves for preventing moisture regain, add 0.5Kg, magnesium stearate behind the uniform mixing, after sending granulator to and granulating, is sent tire bagger to and is distributed into capsule.

Claims (4)

1, a kind of preparation method of medical Fructus phyllanthi capsule is characterized in that this capsule for medicine is is main material with the Fructus Phyllanthi fruit, through emblic juice squeeze, process such as filtration, vacuum concentration, drying, granulation, dress capsule, packing is prepared from.

2, method according to claim 1 is characterized in that thickening temperature is controlled at 50-60 ℃ in the vacuum concentration operation, and vacuum is at 650-720mmHg.

3, method according to claim 1, it is characterized in that drying process can adopt following two kinds of seasonings: spray drying method and bake drying method, above-mentioned spray drying method is 1-5% food starch or the medical starch that adds the fruit juice amount at the emblic juice of concentration, after stirring, send the spray dryer spray drying to, its inlet temperature is controlled at 125-150 ℃, and temperature of outgoing air is controlled at 70-80 ℃, gets emblic powder water content below 6%; Above-mentioned bake drying method is food starch or the medical starch that adds fruit juice amount 1-5% in the emblic juice of concentration, after stirring, places 60 ℃ of following temperature to dry to water content below 9%.

4, method according to claim 1 is characterized in that in the granulation process, and for preventing the moisture regain of emblic powder, the magnesium stearate addition is 0.1-0.5% of an emblic juice.