CN112755405B - Photoacoustic dynamic therapy device - Google Patents
Photoacoustic dynamic therapy device Download PDFInfo
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- CN112755405B CN112755405B CN202110067067.7A CN202110067067A CN112755405B CN 112755405 B CN112755405 B CN 112755405B CN 202110067067 A CN202110067067 A CN 202110067067A CN 112755405 B CN112755405 B CN 112755405B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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Abstract
本发明属于医疗器械技术领域，具体涉及一种光声动力治疗仪。一种光声动力治疗仪，包括机箱，其特征在于：还包括声光发生装置和控制部件；声光发生装置和控制部件均设置在机箱内；声光发生装置电性连接至控制部件；声光发生装置能够单独发射激光或超声波，也能够同时发射激光和超声波。本申请通过将光动力技术和声动力技术相结合，提供了一种能够同时用于浅表和深层组织疾病无创声光同步治疗的便携设备，相比现有技术，具有操作方便简单、敏化剂用量少以及治疗效果有保障等技术效果。
The present invention belongs to the technical field of medical devices, and specifically relates to a photoacoustic therapy apparatus. A photoacoustic therapy apparatus includes a chassis, characterized in that: it also includes an acoustic-light generator and a control component; the acoustic-light generator and the control component are both arranged in the chassis; the acoustic-light generator is electrically connected to the control component; the acoustic-light generator can emit laser or ultrasonic waves alone, and can also emit laser and ultrasonic waves at the same time. This application combines photodynamic technology with acoustic-dynamic technology to provide a portable device that can be used for non-invasive acoustic-light synchronous treatment of superficial and deep tissue diseases. Compared with the prior art, it has the technical effects of being easy to operate, using less sensitizer, and having a guaranteed treatment effect.
Description
Technical Field
The application belongs to the technical field of medical equipment, and particularly relates to a photoacoustic power therapeutic apparatus.
Background
Current lasers used for photodynamic therapy (PDT) can only provide light of one or several wavelengths, and due to the limited penetration of the laser, the function of the laser is limited and can only be used for treating superficial lesions. While an acoustic power therapeutic apparatus for acoustic power therapy (SDT) can penetrate deep tissues by using an ultrasonic activated sensitizer, making up for the deficiency of PDT.
Content of the application
In view of the above, the present application provides a photoacoustic power therapeutic apparatus to solve the technical problems existing in the prior art.
The application adopts the following solution scheme for solving the technical problems:
The photoacoustic power therapeutic apparatus comprises a case and is characterized by further comprising an acousto-optic generating device and a control component, wherein the acousto-optic generating device and the control component are both arranged in the case, the acousto-optic generating device is electrically connected to the control component, and the acousto-optic generating device can emit laser or ultrasonic waves independently and can emit laser and ultrasonic waves simultaneously.
Preferably, the acousto-optic generating device comprises a laser generator, an acousto-optic modulator, an ultrasonic oscillating circuit and an ultrasonic transducer, wherein the laser generator and the ultrasonic oscillating circuit are electrically connected to the control component, the laser generator is used for emitting laser, the acousto-optic modulator is used for adjusting the laser emitted by the laser generator, the ultrasonic oscillating circuit is used for generating ultrasonic oscillation, and the ultrasonic transducer is used for converting the ultrasonic oscillation generated by the ultrasonic oscillating circuit into ultrasonic waves.
Preferably, the acousto-optic generating device comprises a laser generator, an acousto-optic transmission tunnel and an acousto-optic synchronization component, wherein the laser generator is used for emitting laser, the acousto-optic synchronization component is used for forming a ring array laser source and generating ultrasonic waves through cooperation of the acousto-optic transmission tunnel, and the acousto-optic transmission tunnel is used for transmitting the laser generated by the acousto-optic synchronization component and the ultrasonic waves.
The cross section of the acousto-optic transmission tunnel is preferably of a right circular structure, the acousto-optic synchronization component comprises a cylindrical portion and a conical portion, annular grating arrays which are mutually communicated are arranged in the cylindrical portion and the conical portion, the acousto-optic synchronization component is arranged in the acousto-optic transmission tunnel and is mutually overlapped with the axis of the acousto-optic transmission tunnel, and the conical portion of the acousto-optic synchronization component faces the incident end of laser.
Preferably, the laser generator is a laser diode.
Preferably, the acousto-optic generating device further comprises a laser beam expander, and the laser beam expander is arranged between the laser generator and the acousto-optic synchronous component and used for adjusting the irradiation form of the laser beam.
Preferably, the acousto-optic generating device further comprises an acousto-optic modulator for adjusting the intensity and frequency of concentric annular laser sources formed by the annular grating array.
Preferably, the acousto-optic generating device is capable of emitting one or more of 193-337nm ultraviolet light, 488nm blue light, 514nm green light, 633nm red light, 1064nm near infrared light, and 570-650nm tunable light.
Preferably, the ultrasonic frequency generated by the acousto-optic generating device is 100kHz to 2MHz.
Preferably, the photoacoustic power therapeutic apparatus further comprises a laser intensity adjusting part, a laser frequency adjusting part, an ultrasonic intensity adjusting part and an ultrasonic frequency adjusting part, wherein the laser intensity adjusting part, the laser frequency adjusting part, the ultrasonic intensity adjusting part and the ultrasonic frequency adjusting part are all arranged in and/or on the case, and the laser intensity adjusting part, the laser frequency adjusting part, the ultrasonic intensity adjusting part and the ultrasonic frequency adjusting part are all electrically connected to the control part.
Preferably, the photoacoustic power therapeutic apparatus further comprises a laser display and an ultrasonic display, wherein the laser display and the ultrasonic display are arranged in and/or on the chassis, and the laser display and the ultrasonic display are electrically connected to the control component.
Preferably, the photoacoustic power therapeutic apparatus further comprises a laser waveguide device and an ultrasonic waveguide device, wherein the laser waveguide device and the ultrasonic waveguide device are arranged in and/or on the case, and the laser waveguide device and the ultrasonic waveguide device are electrically connected to the acousto-optic generating device.
Preferably, the photoacoustic power therapeutic apparatus further includes a photoacoustic waveguide device for transmitting laser light and/or ultrasonic waves.
The beneficial technical effects are as follows:
1. the application provides a portable device which can be used for noninvasive treatment of superficial and deep tissue diseases simultaneously by combining photoacoustic power technology. Compared with the prior art, the method has the technical effects of convenient and simple operation, less sensitizer consumption, guaranteed treatment effect and the like.
2. In the embodiment of the application adopting the laser generator, the acousto-optic transmission tunnel and the acousto-optic synchronization component as the acousto-optic generation device, the application not only can be used for the noninvasive acousto-optic synchronization treatment of superficial and deep tissue diseases at the same time, but also has the technical effects of uniform energy distribution, good synchronization performance of photoacoustic signals, simple operation, convenient use and the like. Meanwhile, the annular laser source is used as the laser source for acousto-optic synchronous treatment, and the laser source has the technical effects of high energy efficiency, small side effect on human bodies, higher safety performance and the like.
The technical scheme and technical effects of the present application are described in detail below with reference to the drawings and the detailed description of the specification.
Drawings
FIG. 1 is a schematic view of a first preferred embodiment;
FIG. 2 is a schematic diagram of a second preferred embodiment;
FIG. 3 is a schematic diagram of the structure of the acousto-optic generating device;
FIG. 4 is a front perspective view of the acousto-optic synchronization assembly;
FIG. 5 is a side perspective view of an acousto-optic synchronization component;
Identification description:
10-acousto-optic generating device, 20-laser intensity adjusting part, 30-laser frequency adjusting part, 40-ultrasonic intensity adjusting part, 50-ultrasonic frequency adjusting part, 60-laser display, 70-ultrasonic display, 80-laser waveguide device, 90-ultrasonic waveguide device, 100-photoacoustic waveguide device;
110-a laser generator, 120-an acousto-optic transmission tunnel and 130-an acousto-optic synchronization component;
1310-cylindrical portion, 1320-conical portion, 1330-annular grating array.
Detailed Description
First preferred embodiment
Referring to fig. 1, a photoacoustic power therapeutic apparatus includes a housing in which an acousto-optic generating device 10, a laser intensity adjusting part 20, a laser frequency adjusting part 30, an ultrasonic intensity adjusting part 40, an ultrasonic frequency adjusting part 50, a laser display 60, an ultrasonic display 70, a laser waveguide 80, an ultrasonic waveguide 90 and a control part are disposed, the laser intensity adjusting part 20, the laser frequency adjusting part 30, the ultrasonic intensity adjusting part 40, the ultrasonic frequency adjusting part 50, the laser display 60 and the ultrasonic display 70 are disposed in and/or on the housing and electrically connected to the control part, and the laser waveguide 80 and the ultrasonic waveguide 90 are connected to the acousto-optic generating device 10 for receiving and transmitting laser and/or ultrasonic waves emitted by the acousto-optic generating device 10.
The acousto-optic generating device 10 comprises a laser generator, an acousto-optic modulator, an ultrasonic oscillating circuit and an ultrasonic transducer, wherein the laser generator and the ultrasonic oscillating circuit are electrically connected to a control part. The laser generator is used for emitting laser, the acousto-optic modulator is used for adjusting the laser emitted by the laser generator, the ultrasonic oscillating circuit is used for generating ultrasonic oscillation, and the ultrasonic transducer is used for converting the ultrasonic oscillation generated by the ultrasonic oscillating circuit into ultrasonic waves.
The laser waveguide 80 and the ultrasonic waveguide 90 are used to receive and transmit laser light emitted from a laser generator and ultrasonic waves generated from an ultrasonic transducer, respectively. Various waveguide devices or components of the prior art can be employed as the laser waveguide device and the ultrasonic waveguide device of the present application, and flexible waveguide devices or components are preferably employed.
The laser generator may be various laser emitting components or parts such as a laser or a laser diode, etc. as known in the art. The acousto-optic modulator, ultrasonic oscillating circuit and ultrasonic transducer may be any of the corresponding components or parts of the prior art having the same or similar functionality. The control component may be a control circuit board, a control chip or a microcomputer such as an industrial personal computer or the like.
The acousto-optic generating device 10 is electrically connected to the control part, and the acousto-optic generating device 10 can emit laser or ultrasonic wave independently or simultaneously. Preferably, the acousto-optic generating device 10 is capable of emitting any one or more of 193-337nm ultraviolet light, 488nm blue light, 514nm green light, 633nm red light, 1064nm near infrared light and 570-650nm tunable light, and the ultrasonic frequency generated by the acousto-optic generating device 10 is 100kHz to 2MHz.
Mode description 1, photodynamic therapy (PDT) mode, laser generator and acousto-optic modulator are in on state, ultrasonic oscillating circuit and ultrasonic transducer are in off state. The laser intensity and frequency can be adjusted to appropriate levels by the laser intensity adjustment means 20 and the laser frequency adjustment means 30, and the adjusted laser beam is conducted to the affected part by the laser waveguide 80. 2. Acoustic power therapy (SDT), laser generator and acousto-optic modulator are in off state, and ultrasound oscillating circuit and ultrasound transducer are in on state. The intensity and frequency of the ultrasonic wave can be adjusted to an appropriate level by the ultrasonic intensity adjusting part 40 and the ultrasonic frequency adjusting part 50, and the adjusted ultrasonic wave is transmitted to the affected part by the ultrasonic guide 90. 3. In the photoacoustic power combined treatment mode, the laser generator, the acousto-optic modulator, the ultrasonic oscillating circuit and the ultrasonic transducer are all in a starting state. The laser and ultrasonic waves can be conducted to the affected part through the laser waveguide device 80 and the ultrasonic waveguide device 90 sequentially or simultaneously, and the intensity of the laser and ultrasonic waves can be adjusted through the laser intensity adjusting part 20, the laser frequency adjusting part 30, the ultrasonic intensity adjusting part 40 and the ultrasonic frequency adjusting part 50. According to clinical contrast, the efficacy of the photoacoustic power combined synchronous therapy mode is better than that of the photodynamic therapy (PDT) mode and the photodynamic therapy (SDT) mode, and that of the photoacoustic power combined asynchronous therapy mode.
The application provides the portable acousto-optic power equipment which can be used for noninvasive treatment of the superficial and deep tissue diseases simultaneously by combining the photoacoustic power technology. Compared with the prior art, the method has the technical effects of convenient and simple operation, less sensitizer consumption, guaranteed treatment effect and the like.
Second preferred embodiment
Referring to fig. 2, another photoacoustic power-driven therapeutic apparatus is disclosed in this embodiment, which includes a housing, an acousto-optic generating device 10, a laser display 60, a photoacoustic waveguide device 100, and a control means. The functions and connection of the cabinet, the acousto-optic generating device 10, the laser display 60 and the control part are the same as those of the first preferred embodiment. Reference is made to the implementation by those skilled in the art.
The acousto-optic generating device 10 in this embodiment includes a laser generator 110, an acousto-optic transmission tunnel 120 and an acousto-optic synchronization part 130, wherein the laser generator 110 is used for emitting laser, the acousto-optic synchronization part 130 is used for forming a ring array laser source and generating ultrasonic waves through cooperation of the acousto-optic transmission tunnel 120, and the acousto-optic transmission tunnel 120 is used for transmitting the laser and the ultrasonic waves generated by the acousto-optic synchronization part 130 and transmitting optical acoustic energy to the photoacoustic waveguide device 100. Photoacoustic wave-guide device 100 is used to conduct photoacoustic energy to a patient site.
The cross section of the acousto-optic transmission tunnel 120 has a right circular structure, the acousto-optic synchronization component 130 comprises a cylindrical portion 1310 and a conical portion 1320, annular grating arrays 1330 which are mutually communicated are arranged in the cylindrical portion 1310 and the conical portion 1320, the acousto-optic synchronization component 130 is arranged in the acousto-optic transmission tunnel 120 and is mutually overlapped with the axis of the acousto-optic transmission tunnel 120, and the conical portion 1320 of the acousto-optic synchronization component 130 faces the incident end of laser.
The laser generator may be various laser emitting components or parts such as a laser or a laser diode, etc. as known in the art. Preferably, the laser generator 110 is capable of emitting any one or more of 193-337nm ultraviolet light, 488nm blue light, 514nm green light, 633nm red light, 1064nm near infrared light, and 570-650nm tunable light. The frequency of the ultrasonic waves generated by the acousto-optic synchronization component 130 and the acousto-optic transmission tunnel 120 is between 100kHz and 2 MHz.
The acousto-optic transmission tunnel 120 may be any waveguide member or assembly capable of conducting laser and ultrasonic waves in the prior art, and preferably a metallic material such as aluminum is used. Photoacoustic waveguide 100 may be any of a variety of waveguide devices or components known in the art, with pliable waveguide devices or components being preferred.
The principle is that the laser beam emitted from the laser generator irradiates the acousto-optic synchronization part 130, one part of the laser beam is reflected by the conical reflecting surface of the conical part 1320 to the inner surface of the acousto-optic transmission tunnel 120 to form an annular laser spot, and the other part of the laser beam forms a concentric annular laser source shown by an arrow pointing part in fig. 2 through the annular grating array 1330. The inner surface of the acousto-optic transmission tunnel 120 generates longitudinal waves, transverse waves and surface waves under the action of the annular laser spot, and the longitudinal waves, transverse waves and surface waves are coupled into ultrasonic guided waves in the transmission process. The ultrasonic guided wave and the annular laser source are conducted to the affected part through the photoacoustic waveguide device 100 to realize acousto-optic synchronous treatment.
The photoacoustic power therapeutic apparatus provided in the embodiment not only can be used for noninvasive acousto-optic synchronous treatment of superficial and deep tissue diseases at the same time, but also has the technical effects of uniform energy distribution, good photoacoustic signal synchronization performance, simplicity in operation, convenience in use and the like. Meanwhile, the embodiment adopts the annular laser source as the laser source for acousto-optic synchronous treatment, and has the technical effects of high energy efficiency, small side effect on human body, higher safety performance and the like.
In another variation of the present embodiment, the acousto-optic generating device 10 further includes a laser beam expander, and the laser beam expander is disposed between the laser generator 110 and the acousto-optic synchronization component 130, for adjusting the irradiation form of the laser beam.
In another variation of this embodiment, the acousto-optic generating device 10 further includes an acousto-optic modulator for adjusting the intensity and frequency of the concentric annular laser sources formed by the annular grating array 1330.
The technical solution and the technical effects of the present application have been described in detail above with reference to the drawings and the specific embodiments of the present application, it should be noted that the specific embodiments disclosed in the specification are only preferred embodiments of the present application, and other embodiments can be developed on the basis of the above description, and any simple modification and equivalent substitution without departing from the innovative concepts of the present application are covered by the present application, and belong to the protection scope of the present patent.
Claims (7)
1. The photoacoustic power therapeutic apparatus comprises a case and is characterized by also comprising an acousto-optic generating device (10) and a control part;
the sound-light generating device (10) and the control part are both arranged in the case;
the acousto-optic generating device (10) is electrically connected to the control component, and the acousto-optic generating device (10) can emit laser or ultrasonic waves independently and can emit laser and ultrasonic waves simultaneously;
The acousto-optic generation device (10) comprises a laser generator (110), an acousto-optic transmission tunnel (120) and an acousto-optic synchronization component (130);
the laser generator (110) is used for emitting laser, the acousto-optic synchronization component (130) is used for forming a ring array laser source and generating ultrasonic waves through cooperation of the acousto-optic transmission tunnel (120), and the acousto-optic transmission tunnel (120) is used for transmitting the laser and the ultrasonic waves generated by the acousto-optic synchronization component (130);
the cross section of the acousto-optic transmission tunnel (120) has a right circular structure;
The acousto-optic synchronization component (130) comprises a cylindrical part (1310) and a conical part (1320), wherein an annular grating array (1330) which is mutually communicated is arranged inside the cylindrical part (1310) and the conical part (1320);
The acousto-optic synchronization component (130) is arranged inside the acousto-optic transmission tunnel (120), the axes of the acousto-optic synchronization component (130) and the acousto-optic transmission tunnel (120) are mutually overlapped, and the conical part (1320) of the acousto-optic synchronization component (130) faces the incident end of laser;
The acousto-optic generating device (10) further comprises a laser beam expander, wherein the laser beam expander is arranged between the laser generator (110) and the acousto-optic synchronization component (130) and is used for adjusting the irradiation form of the laser beam.
2. The photoacoustic power-driven therapeutic apparatus according to claim 1, wherein:
The acousto-optic generating device (10) comprises a laser generator, an acousto-optic modulator, an ultrasonic oscillating circuit and an ultrasonic transducer;
The laser generator is used for emitting laser, the acousto-optic modulator is used for adjusting the laser emitted by the laser generator, the ultrasonic oscillation circuit is used for generating ultrasonic oscillation, and the ultrasonic transducer is used for converting the ultrasonic oscillation generated by the ultrasonic oscillation circuit into ultrasonic waves.
3. The photoacoustic power-driven therapeutic apparatus according to claim 1, wherein:
The acousto-optic generation device (10) further comprises an acousto-optic modulator for adjusting the intensity and frequency of concentric annular laser sources formed by the annular grating array (1330).
4. The photoacoustic power-driven therapeutic apparatus according to claim 1, wherein the acousto-optic generating means (10) is capable of emitting one or more of 193-337nm ultraviolet light, 488nm blue light, 514nm green light, 633nm red light, 1064nm near infrared light and 570-650nm tunable light, and the ultrasonic frequency generated by the acousto-optic generating means (10) is 100kHz to 2MHz.
5. The photoacoustic power-driven therapeutic apparatus according to any one of claims 1 through 4, wherein:
The photoacoustic power therapeutic apparatus further comprises a laser intensity adjusting component (20), a laser frequency adjusting component (30), an ultrasonic intensity adjusting component (40) and an ultrasonic frequency adjusting component (50);
The laser intensity adjusting component (20), the laser frequency adjusting component (30), the ultrasonic intensity adjusting component (40) and the ultrasonic frequency adjusting component (50) are arranged in and/or on the chassis;
The laser intensity adjusting component (20), the laser frequency adjusting component (30), the ultrasonic intensity adjusting component (40) and the ultrasonic frequency adjusting component (50) are electrically connected to the control component.
6. The photoacoustic power-driven therapeutic apparatus according to any one of claims 1 through 4, wherein:
The photoacoustic power therapeutic apparatus further comprises a laser display (60), an ultrasonic display (70), a laser waveguide device (80) and an ultrasonic waveguide device (90);
the laser display (60), the ultrasonic display (70), the laser waveguide device (80) and the ultrasonic waveguide device (90) are arranged in and/or on the chassis;
The laser display (60) and the ultrasonic display (70) are electrically connected to the control component, and the laser waveguide device (80) and the ultrasonic waveguide device (90) are electrically connected to the acousto-optic generating device (10).
7. The photoacoustic power-driven therapeutic apparatus according to any one of claims 1 through 4, wherein:
The photoacoustic power therapeutic apparatus further comprises a photoacoustic waveguide device (100), and the photoacoustic waveguide device (100) is used for transmitting laser and/or ultrasonic waves.
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| CN215136069U (en) * | 2021-01-19 | 2021-12-14 | 北京大学深圳医院 | A photoacoustic dynamic therapy device |
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| JPH08320310A (en) * | 1995-05-26 | 1996-12-03 | Nippon Steel Corp | Ultrasonic generating method and laser ultrasonic device |
| JPH10201769A (en) * | 1997-01-24 | 1998-08-04 | Osada Res Inst Ltd | Laser beam and ultrasonic vibration therapeutic device |
| US6761729B2 (en) * | 2000-12-22 | 2004-07-13 | Advanced Medicalapplications, Inc. | Wound treatment method and device with combination of ultrasound and laser energy |
| US7153299B1 (en) * | 2003-02-24 | 2006-12-26 | Maxwell Sensors Inc. | Optical apparatus for detecting and treating vulnerable plaque |
| KR101098257B1 (en) * | 2010-01-22 | 2011-12-23 | 전북대학교산학협력단 | A laser wavelength stabilized simultaneous multipoint fiber Bragg grating acousto-ultrasonic sensing system |
| US20120029394A1 (en) * | 2010-02-05 | 2012-02-02 | Bacoustics, Llc | Ultrasound Assisted Laser Skin and Tissue Treatment |
| KR20140029751A (en) * | 2012-08-30 | 2014-03-11 | 현대제철 주식회사 | Apparatus for generating ultrasonic wave induced laser and method for controlling the same |
| JP7039371B2 (en) * | 2017-11-22 | 2022-03-22 | 株式会社東芝 | Laser-excited ultrasonic generator, laser ultrasonic inspection device, and laser ultrasonic inspection method |
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Address after: 518000 Lianhua Road, Shenzhen, Guangdong, No. 1120, No. Patentee after: PEKING University SHENZHEN HOSPITAL (PEKING UNIVERSITY SHENZHEN CLINIC MEDICAL COLLEGE) Country or region after: China Patentee after: SHENZHEN PKU-HKUST MEDICAL CENTER Address before: 518000 Lianhua Road, Shenzhen, Guangdong, No. 1120, No. Patentee before: PEKING UNIVERSITY SHENZHEN Hospital Country or region before: China Patentee before: SHENZHEN PKU-HKUST MEDICAL CENTER |