CN112641539A - Method for increasing bone volume of personalized coral hydroxyapatite artificial bone block by oral implantation and application thereof - Google Patents
Method for increasing bone volume of personalized coral hydroxyapatite artificial bone block by oral implantation and application thereof Download PDFInfo
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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Abstract
The invention provides an oral implant bone augmentation method of an individualized coral hydroxyapatite artificial bone block and application thereof. The oral bone grafting increment of the individualized coral hydroxyapatite artificial bone block is completed through the steps of scanning, data acquisition, design, manufacture and sterilization. The individualized coral hydroxyapatite artificial bone block of the present invention may be used in preparing bone block for oral bone grafting. The personalized coral hydroxyapatite artificial bone block prepared by the preparation method of the invention fills gaps of the joint surfaces of the bone block and the bone defect area by the artificial bone powder or autologous bone chips, can realize complete matching with the bone defect area of a patient, gives consideration to bone defect at three-dimensional position, and simultaneously gives consideration to recovery of bone height and bone width. Is particularly suitable for preparing bone blocks with complex bone increment in bone defect areas.
Description
Technical Field
The invention belongs to the technical field of medical treatment, and particularly relates to an oral implantation bone augmentation method for an individualized coral hydroxyapatite artificial bone block and application thereof.
Background
The problem of bone increment is always a hotspot and a difficult point of implant repair. Trauma, extractions, periodontal disease, jaw bone lesions, etc., all result in varying degrees of loss of alveolar bone height and width. These patients need corresponding bone grafting operation when carrying out the implantation operation. The commonly used bone augmentation means include guided bone regeneration, bone extrusion, bone dissection, maxillary sinus lifting, autologous bone block transplantation and the like, which have respective indications and limitations. The single use or combined use of guided bone regeneration, bone extrusion and bone splitting all require alveolar ridge widths above 3mm and are mainly directed at horizontal bone mass defects. For severe alveolar ridge defects with alveolar bone widths below 3mm, bone augmentation using autologous bone block grafting techniques is required.
In addition to bone augmentation techniques, research into the use of bone grafting materials has also been advanced. The autologous bone block transplantation is a recognized bone grafting gold standard, has no immunological rejection, and has three functions of bone guiding, bone induction and bone generation, but the autologous bone block transplantation operation has large trauma, slow postoperative recovery, too fast bone block absorption rate, increased infection probability, easy exposure of bone blocks and easy damage to mental nerves; allogeneic bone has abundant bone source and is widely applied clinically; the bone substitute is prepared from Os bovis Seu Bubali such as calcined Os bovis Seu Bubali, and Hydroxyapatite (HA) as effective component, which is extracted from Os bovis Seu Bubali and HAs porosity, bone guiding and bone inducing effects. The bone augmentation method of the invention realizes bone augmentation in oral implantation by using artificial bone blocks prepared from Coral Hydroxyapatite (CHA).
Disclosure of Invention
The invention aims to provide an oral implantation bone augmentation method of an individualized coral hydroxyapatite artificial bone block and application thereof, which solve the problem of bone augmentation caused by serious bone defect in oral implantation.
In order to achieve the purpose, the technical scheme of the invention is as follows:
the oral implant bone augmentation method of the individualized coral hydroxyapatite artificial bone block is provided, and comprises the following steps:
(1) scanning: shooting a CBCT of the oral cavity of a patient to obtain CBCT scanning data;
(2) acquiring data: importing the CBCT scanning data obtained in the step (1) into editing software, and establishing an image by using a three-dimensional reconstruction function to obtain bone defect region data;
(3) designing: importing the bone defect region data obtained in the step (2) into design software, carrying out three-dimensional modeling on the bone defect region, reserving fixing holes, and generating a bone block effect diagram and design data;
(4) preparation: importing the design data obtained in the step (3) into a processing machine, and selecting coral hydroxyapatite finished bone blocks with proper sizes to obtain individualized coral hydroxyapatite artificial bone blocks;
(5) and (3) sterilization: and (4) sterilizing the personalized coral hydroxyapatite artificial bone block prepared in the step (4).
Further, the editing software in the step (2) includes mics, and the designing software in the step (3) includes 3 Shape.
Furthermore, the size of the fixing holes in the step (3) is matched with that of the titanium nails, and the number of the fixing holes is 1-15.
Further, the step (3) further comprises reserving a filling gap, and the contact surface is subjected to gentle treatment.
Further, the machining machine in the step (4) is a cutting machining machine.
Further, the fixing hole is a penetrating hole.
Further, the reserved filling gap is filled with artificial bone powder or autologous bone fragments.
Further, the oral cavity bone implantation augmentation method of the personalized coral hydroxyapatite artificial bone mass further comprises covering the surface of the personalized coral hydroxyapatite artificial bone mass with an absorbable biological membrane or a PRF membrane.
The invention provides an individualized coral hydroxyapatite artificial bone block prepared by the oral cavity bone grafting augmentation method of the individualized coral hydroxyapatite artificial bone block.
The invention also provides application of the personalized coral hydroxyapatite artificial bone block in preparing an artificial bone block for bone increment.
Furthermore, the artificial bone block is alveolar bone.
Compared with the prior art, the invention has the advantages and beneficial effects that:
the invention relates to a method for increasing bone mass in oral cavity implantation of individualized coral hydroxyapatite artificial bone mass and application thereof, wherein the individuation is embodied in that compared with a finished product of heterogeneous bone mass, the individualized coral hydroxyapatite artificial bone mass is manufactured by design; the bone defect recovery device can be completely matched with a bone defect area of a patient, gives consideration to bone defect at a three-dimensional position, and simultaneously gives consideration to recovery of bone height and bone width. The material adopts bone blocks of coral hydroxyapatite, artificial bone powder or autologous bone fragments of a patient to fill the joint surface of the bone grafting block and the tissue surface, and the surface is covered with an absorbable biological membrane; not only retains the unique advantages of coral hydroxyapatite, but also can promote bone defect healing. And the fixing hole is reserved, the defect that the finished heterogeneous bone block is easy to crack when being punched is effectively avoided, a better bone increment effect can be achieved, and the problems of trauma, pain, nerve injury and the like caused by using the autologous bone block to take the bone are avoided. The invention avoids the condition that the edge and the periphery of the finished product heterogeneous artificial bone block are not coordinated and the fracture of the postoperative bone block possibly caused by external force is avoided, and the invention can play a good role in morphological support, and the porous structure of the invention can be used as a bracket and has a good bone guiding function.
Drawings
FIG. 1 is a pre-operative CBCT image of a patient; wherein A: the lateral labial position; b: the tongue is on the side; c: and the angle is 45 degrees.
Fig. 2 is a schematic diagram of a patient's design of a personalized customized CHA artificial bone mass, wherein a: a front view; b: a rear view; c: a right view; d: and (7) bottom view.
FIG. 3 is a matching graph of a patient's personalized customized CHA artificial bone mass to a bone defect area; wherein, A: the lateral lip of the front; b: the tongue side position on the front side; c: facing upward at 45 degrees to the lateral labial position; d: facing 45 degrees to the lateral side of the tongue; e: the left side position.
FIG. 4 is a patient pre-operative CBCT image; wherein A: righting; b: a right side bit; c: and the angle is 45 degrees.
Fig. 5 is a schematic diagram of a design of a patient's two personalized CHA artificial bone mass, wherein a: a front view; b: a left view; c: and (7) bottom view.
FIG. 6 is a matching graph of patient two personalized CHA artificial bone pieces and bone defect areas; wherein, A: the lateral lip of the front; b: lateral position; c: and the angle is 45 degrees.
FIG. 7 is a CBCT map of a patient before three operations; wherein A: righting; b: lateral position; c: and the angle is 45 degrees.
Fig. 8 is a schematic diagram of a patient's three personalized customized CHA artificial bone mass design, wherein a: a front view; b: a right view; c: and (7) bottom view.
FIG. 9 is a matching graph of a patient's three personalized customized CHA artificial bone pieces with a bone defect area; wherein, A: the lateral lip of the front; b: lateral position; c: and the angle is 45 degrees.
FIG. 10 is a view of the personalized CHA artificial bone block of the present invention, wherein A is the artificial bone block of example 3; b is the artificial bone piece prepared in example 4.
Detailed Description
The following embodiments better illustrate the present invention. However, the present invention is not limited to the following examples.
The invention takes Coral Hydroxyapatite (CHA) as a raw material to obtain CBCT of the oral cavity of a patient, and uses related software and equipment, such as Mimics software, 3Shape software, Sinoded three-dimensional numerical control dental professional machine tool and the like to design the bone block Shape matched with a bone defect area, cut, process and manufacture the bone block, and then the bone block is applied to clinic after professional sterilization and disinfection and qualified detection.
Selection of bone grafting materials:
the bone source of the allogeneic bone is rich, the potential of osteogenesis is avoided, the allogeneic bone still has good bone conduction and bone induction characteristics, but the bone grafting has delayed healing, nonhealing, immunological rejection and the like, and the infection rate of the allogeneic transplantation is about 1.2-9%.
Hydroxyapatite (HA) is a substance extracted from bovine bone and having porosity, bone guiding property and bone inducing effect, the active ingredient is mainly hydroxyapatite, the microporous structure of the hydroxyapatite is similar to natural bone and can effectively support and guide the growth of new bone to depth, the slow absorption and the porous structure of the hydroxyapatite provide a bracket for the growth of new bone and new blood vessels, and the hydroxyapatite is a good material for repairing bone defect.
Coral Hydroxyapatite (CHA) has the unique advantages of good biocompatibility, good bone conduction, no immunogenicity and the like, and has good effect of guiding bone regeneration as a granular form. However, the finished product of the blocky coral hydroxyapatite is brittle, is difficult to retain by using a titanium nail, is easy to have the situation of bone block fragmentation, has a single shape, cannot perfectly fit with a defect part, and cannot simultaneously recover the bone height and the bone width.
The invention adopts coral hydroxyapatite as bone grafting material, avoids the use defects thereof through specific design and improves the use effect.
Example 1
1. Scanning: the Cone Beam CT (CBCT) of the bone defect part of the patient is shot, CBCT scanning data in a Dicom format is derived from CBCT software, and the CBCT scanning data is obtained.
2. Acquiring data: and (2) importing the CBCT scanning data obtained in the step (1) into editing software (such as Mimics software), selecting a three-dimensional reconstruction function to reconstruct a jaw bone image of a patient, selecting a bone defect area, deleting other unnecessary areas, and storing the file in an STL format.
3. Designing: the file stored in the STL format is imported into design software (such as 3Shape software), three-dimensional modeling (near-far middle, buccal-lingual and vertical) is carried out on a bone defect region, in order to avoid bone fracture caused by punching during fixation, a proper amount of fixing holes (penetrating holes) matched with the retention titanium nails are reserved according to the condition of a patient, 1-15 fixing holes are generally reserved, complicated parts of the bone defect region appear, the condition that the fitting degree of a bone implant block and a tissue surface is poor is considered, the individualized bone block is designed to be light and thin, the volume of an artificial bone block is smaller than that of the bone defect region, gaps are reserved on a contact surface, the complicated surface is gently processed, an individualized bone block effect diagram and design data are generated, and the bone defect region (height and width) is recovered.
4. Preparation: and (3) importing the design data into a manufacturing cutting machine (a three-dimensional numerical control dental professional machine tool of Sinuode), selecting a standard-form Coral Hydroxyapatite (CHA) finished bone block with a proper size, cutting the bone block according to a design scheme, and manufacturing the individualized coral hydroxyapatite artificial bone block for restoring bone defects.
5. And (3) sterilization: and performing professional sterilization treatment on the prepared personalized coral hydroxyapatite artificial bone block.
6. Installation (clinical application): fixing the sterilized artificial bone block in a bone defect area through a reserved fixing hole by using a titanium nail, finely adjusting the artificial bone block according to the matching condition, and fixing by selecting the reserved fixing hole according to the operation condition; the surface of the artificial bone block contacted with the soft tissue is covered with an absorbable biomembrane (or PRF membrane) to promote the healing of bone defect, and the gap between the bone grafting block and the tissue surface is filled with artificial bone powder or autologous bone fragments of a patient to realize the perfect fit of the coral hydroxyapatite material and the defect part.
Example 2
1. Scanning: a Cone Beam CT (CBCT) of a bone defect part of a patient is shot, as shown in figure 1, 11 and 12 parts are lost, the bone defect is serious, the alveolar bone is seriously damaged, CBCT scanning data in a Dicom format is derived from CBCT software, and the CBCT scanning data is obtained.
2. Acquiring data: and (2) importing the CBCT scanning data obtained in the step (1) into editing software (such as Mimics software), selecting a three-dimensional reconstruction function to reconstruct a jaw bone image of a patient, selecting a bone defect area, deleting other unnecessary areas, and storing the file in an STL format.
3. Designing: and (3) importing the file stored in the STL format into design software (such as 3Shape software), carrying out three-dimensional modeling on a bone defect region, reserving 3 fixing holes, wherein the diameter of each fixing hole is 1.6mm, the volume of the artificial bone block is smaller than that of the bone defect region, reserving gaps on a contact surface, and carrying out gentle treatment on a complex surface to generate an individualized bone block effect diagram and design data as shown in figure 2.
4. Preparation: and importing the design data into a Sinuode three-dimensional numerical control dental professional machine tool, selecting a Coral Hydroxyapatite (CHA) finished bone block with a standard form and a proper size, and cutting the bone block according to a design scheme to prepare an individualized coral hydroxyapatite artificial bone block for restoring bone defects.
5. And (3) sterilization: and performing professional sterilization treatment on the prepared personalized coral hydroxyapatite artificial bone block.
6. Installation (clinical application): the titanium nail is used for fixing the sterilized artificial bone block in a bone defect area through the reserved fixing hole, the artificial bone block is finely adjusted according to the matching condition, the matching condition is shown in figure 3, an absorbable biological membrane (or PRF membrane) covers the surface of the artificial bone block, which is in contact with soft tissue, the bone defect healing is promoted, and the gap between the bone grafting block and the tissue surface is filled with artificial bone powder or autologous bone fragments of a patient, so that the coral hydroxyapatite material is perfectly attached to the defect part.
Example 3
1. Scanning: cone Beam CT (CBCT) of two bone defect positions of a patient is shot, as shown in figure 4, 13-23 bone defects and alveolar bone severe bone defects are obtained, CBCT scanning data in a Dicom format are derived from CBCT software, and the CBCT scanning data are obtained.
2. Acquiring data: and (2) importing the CBCT scanning data obtained in the step (1) into editing software (such as Mimics software), selecting a three-dimensional reconstruction function to reconstruct a jaw bone image of a patient II, selecting a bone defect area, deleting other unnecessary areas, and storing the file in an STL format.
3. Designing: and importing the file stored in the STL format into design software (such as 3Shape software), carrying out three-dimensional modeling on a bone defect region, reserving 8 fixing holes, wherein the diameter of each fixing hole is 1.6mm, the volume of the artificial bone block is smaller than that of the bone defect region, reserving gaps on a contact surface, and carrying out gentle treatment on a complex surface to generate an individualized bone block effect diagram and design data as shown in figure 5.
4. Preparation: and (3) importing the design data into a Sinuode three-dimensional numerical control dental professional machine tool, selecting a Coral Hydroxyapatite (CHA) finished bone block with a standard form and a proper size, and cutting the bone block according to a design scheme to prepare an individualized coral hydroxyapatite artificial bone block (shown in figure 10A) for bone defect recovery.
5. And (3) sterilization: and performing professional sterilization treatment on the prepared personalized coral hydroxyapatite artificial bone block.
6. Installation (clinical application): the titanium nail is used for fixing the sterilized artificial bone block in a bone defect area through the reserved fixing hole, the artificial bone block is finely adjusted according to the matching condition, the matching condition is shown in figure 6, an absorbable biological membrane (or PRF membrane) covers the surface of the artificial bone block, which is in contact with soft tissue, the bone defect healing is promoted, and the gap between the bone grafting block and the tissue surface is filled with artificial bone powder or bone fragments of a patient, so that the coral hydroxyapatite material is perfectly attached to the defect part.
Example 4
1. Scanning: three bone defects of the patient, Cone Beam CT (CBCT), were imaged, and as shown in FIG. 7, 14 and 15 bone defects were obtained, CBCT scan data in Dicom format were derived from CBCT software, and CBCT scan data were obtained.
2. Acquiring data: and (2) importing the CBCT scanning data obtained in the step (1) into editing software (such as Mimics software), selecting a three-dimensional reconstruction function to reconstruct a jaw bone image of the patient III, selecting a bone defect area, deleting other unnecessary areas, and storing the file in an STL format.
3. Designing: and importing the file stored in the STL format into design software (such as 3Shape software), carrying out three-dimensional modeling on a bone defect region, reserving 2 fixing holes, wherein the diameter of each fixing hole is 1.6mm, the volume of the artificial bone block is smaller than that of the bone defect region, reserving gaps on a contact surface, and carrying out gentle treatment on a complex surface to generate an individualized bone block effect diagram and design data as shown in figure 8.
4. Preparation: and (3) importing the design data into a Sinuode three-dimensional numerical control dental professional machine tool, selecting a Coral Hydroxyapatite (CHA) finished bone block with a standard form and a proper size, and cutting the bone block according to a design scheme to prepare an individualized coral hydroxyapatite artificial bone block (shown in figure 10B) for bone defect recovery.
5. And (3) sterilization: and performing professional sterilization treatment on the prepared personalized coral hydroxyapatite artificial bone block.
6. Installation (clinical application): the titanium nails are used for fixing the sterilized artificial bone block in a bone defect area through the reserved fixing holes, the artificial bone block is finely adjusted according to the matching condition, the matching condition is shown in figure 9, an absorbable biological membrane (or PRF membrane) covers the surface of the artificial bone block, which is in contact with soft tissue, the bone defect healing is promoted, and the gap between the bone grafting block and the tissue surface is filled with artificial bone powder or bone fragments of a patient, so that the coral hydroxyapatite material is perfectly attached to the defect part.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions.
Claims (10)
1. An oral cavity implanted bone augmentation method for an individualized coral hydroxyapatite artificial bone block is characterized by comprising the following steps:
(1) scanning: shooting a CBCT of the oral cavity of a patient to obtain CBCT scanning data;
(2) acquiring data: importing the CBCT scanning data obtained in the step (1) into editing software, and establishing an image by using a three-dimensional reconstruction function to obtain bone defect region data;
(3) designing: importing the bone defect region data obtained in the step (2) into design software, carrying out three-dimensional modeling on the bone defect region, reserving fixing holes, and generating a bone block effect diagram and design data;
(4) preparation: importing the design data obtained in the step (3) into a processing machine, and selecting coral hydroxyapatite finished bone blocks with proper sizes to obtain individualized coral hydroxyapatite artificial bone blocks;
(5) and (3) sterilization: and (4) sterilizing the personalized coral hydroxyapatite artificial bone block prepared in the step (4).
2. The method for oral bone augmentation of individualized coral hydroxyapatite artificial bone mass according to claim 1, wherein the editing software in step (2) is Mimics and the designing software in step (3) is 3 Shape.
3. The method for increasing the bone mass for oral implantation of the personalized coral hydroxyapatite artificial bone mass according to claim 1, wherein the size of the fixing hole in the step (3) is matched with that of the titanium nail, and the number of the fixing holes is 1-15.
4. The method for increasing bone mass for oral implantation of artificial bone mass of individualized coral hydroxyapatite according to claim 1, wherein the step (3) further comprises reserving a filling gap and smoothing the contact surface.
5. The method for oral bone augmentation of individualized coral hydroxyapatite artificial bone pieces according to claim 1, wherein the machining machine in step (4) is a cutting machining machine.
6. The method of claim 4, wherein the pre-filled voids are filled with artificial bone powder or autologous bone chips.
7. The method of claim 1, wherein the method further comprises covering the surface of the artificial bone piece with an absorbable biofilm or PRF membrane.
8. The individualized coral hydroxyapatite artificial bone piece made by the method for oral bone grafting augmentation of individualized coral hydroxyapatite artificial bone piece of claim 1.
9. Use of the individualized coral hydroxyapatite artificial bone piece of claim 8 in the preparation of an artificial bone piece for bone augmentation.
10. Use according to claim 9, wherein the artificial bone piece is an alveolar bone.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113476183A (en) * | 2021-05-21 | 2021-10-08 | 四川大学 | Method for digitally designing and manufacturing personalized bone block |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1462638A (en) * | 2003-06-18 | 2003-12-24 | 中山大学 | Method for synthesizing artificial bone from carboxylic apatite of coral |
| CN101856514A (en) * | 2010-06-02 | 2010-10-13 | 广州军区广州总医院 | Digital coral hydroxyapatite artificial bone scaffold and its preparation method |
| CN103494649A (en) * | 2013-10-23 | 2014-01-08 | 福建医科大学附属口腔医院 | Improvement of bone splitting carried out below lip-cheek crest in oral implantation |
| CN103919631A (en) * | 2014-04-28 | 2014-07-16 | 四川大学 | Manufacturing method for jaw defect individual restoration |
| CN104055595A (en) * | 2014-07-05 | 2014-09-24 | 南宁越洋科技有限公司 | Artificial dental implant suitable for immediate tooth extraction and implantation, restoration and stress |
| CN105126172A (en) * | 2015-09-28 | 2015-12-09 | 武汉大学 | Preparing and mounting method for dental stent capable of raising alveolar ridge |
| CN106974737A (en) * | 2017-03-29 | 2017-07-25 | 西安康拓医疗技术有限公司 | A kind of personalized mouth cavity planting body and preparation method thereof |
| CN107224335A (en) * | 2016-03-25 | 2017-10-03 | 北京大学口腔医学院 | A kind of kind bone grafting increment guide plate designing and manufacturing method to repair to be oriented to |
| CN111904665A (en) * | 2020-07-22 | 2020-11-10 | 四川大学 | Bone increment auxiliary system, design method and bone increment auxiliary device |
| CN112057132A (en) * | 2020-10-13 | 2020-12-11 | 四川大学 | In situ bone harvesting and bone grafting indicator guide plate in horizontal bone augmentation and its manufacturing method |
-
2021
- 2021-01-19 CN CN202110066551.8A patent/CN112641539A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1462638A (en) * | 2003-06-18 | 2003-12-24 | 中山大学 | Method for synthesizing artificial bone from carboxylic apatite of coral |
| CN101856514A (en) * | 2010-06-02 | 2010-10-13 | 广州军区广州总医院 | Digital coral hydroxyapatite artificial bone scaffold and its preparation method |
| CN103494649A (en) * | 2013-10-23 | 2014-01-08 | 福建医科大学附属口腔医院 | Improvement of bone splitting carried out below lip-cheek crest in oral implantation |
| CN103919631A (en) * | 2014-04-28 | 2014-07-16 | 四川大学 | Manufacturing method for jaw defect individual restoration |
| CN104055595A (en) * | 2014-07-05 | 2014-09-24 | 南宁越洋科技有限公司 | Artificial dental implant suitable for immediate tooth extraction and implantation, restoration and stress |
| CN105126172A (en) * | 2015-09-28 | 2015-12-09 | 武汉大学 | Preparing and mounting method for dental stent capable of raising alveolar ridge |
| CN107224335A (en) * | 2016-03-25 | 2017-10-03 | 北京大学口腔医学院 | A kind of kind bone grafting increment guide plate designing and manufacturing method to repair to be oriented to |
| CN106974737A (en) * | 2017-03-29 | 2017-07-25 | 西安康拓医疗技术有限公司 | A kind of personalized mouth cavity planting body and preparation method thereof |
| CN111904665A (en) * | 2020-07-22 | 2020-11-10 | 四川大学 | Bone increment auxiliary system, design method and bone increment auxiliary device |
| CN112057132A (en) * | 2020-10-13 | 2020-12-11 | 四川大学 | In situ bone harvesting and bone grafting indicator guide plate in horizontal bone augmentation and its manufacturing method |
Non-Patent Citations (1)
| Title |
|---|
| 创意生物工程公司: "珊瑚羟基磷灰石骨板——修复用珊瑚羟基磷灰石复合材料", 《眼科》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113476183A (en) * | 2021-05-21 | 2021-10-08 | 四川大学 | Method for digitally designing and manufacturing personalized bone block |
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