CN112635288B - Radio frequency transmission quadrupole power supply circuit and control method thereof, and power supply device - Google Patents
Radio frequency transmission quadrupole power supply circuit and control method thereof, and power supply device Download PDFInfo
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- CN112635288B CN112635288B CN202011602876.5A CN202011602876A CN112635288B CN 112635288 B CN112635288 B CN 112635288B CN 202011602876 A CN202011602876 A CN 202011602876A CN 112635288 B CN112635288 B CN 112635288B
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- 230000005540 biological transmission Effects 0.000 title claims abstract description 119
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- 230000003321 amplification Effects 0.000 claims description 36
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 26
- 230000001276 controlling effect Effects 0.000 claims description 15
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- 150000002500 ions Chemical class 0.000 abstract description 32
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- 230000035945 sensitivity Effects 0.000 abstract description 5
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- 238000004949 mass spectrometry Methods 0.000 description 3
- 238000004804 winding Methods 0.000 description 3
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- 238000007796 conventional method Methods 0.000 description 2
- 238000001819 mass spectrum Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 101100102627 Oscarella pearsei VIN1 gene Proteins 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
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- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/022—Circuit arrangements, e.g. for generating deviation currents or voltages ; Components associated with high voltage supply
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
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Abstract
The application relates to a radio frequency transmission quadrupole rod power supply circuit, a control method and power supply equipment thereof, which are provided with a plurality of different radio frequency magnetic ring transformers, wherein when ions with different mass ranges and different mass numbers are transmitted, the different radio frequency magnetic ring transformers can be correspondingly gated through a first gating device and a second gating device, so that the ion transmission from ions with low mass numbers to ions with high mass numbers can be realized, the radio frequency high-voltage electric field flexibly matched with different frequency ranges can be generated, the good ion transmission efficiency and instrument sensitivity in the wide mass range can be achieved, and meanwhile, a closed-loop control architecture is realized through a feedback regulating device, so that the radio frequency transmission quadrupole rod power supply circuit has extremely high self-adaption degree and stability, and the application range of a mass spectrometer can be greatly improved.
Description
Technical Field
The application relates to the technical field of ion transmission, in particular to a radio frequency transmission quadrupole rod power supply circuit, a control method thereof and power supply equipment.
Background
Mass spectrometry (Mass Spectrometry) is an analytical method for determining and analyzing the mass-to-charge ratio (m/q) of ions of a sample to be measured. Firstly, an uncharged sample to be detected is ionized, then the ions are separated according to mass-to-charge ratio by an electric field or magnetic field method to obtain a mass spectrum, and qualitative and quantitative results of the sample can be obtained by analyzing the mass spectrum and related information of the sample. Commonly used mass spectrometers are classified by analyzer, and are largely classified into magnetic deflection type mass spectrometers, quadrupole type mass spectrometers, ion trap mass spectrometers, and time-of-flight mass spectrometers.
With the development of mass spectrometry technology, instrument performance indexes of mass spectrometers are continuously improved, and new methods and new technologies are continuously introduced. The method introduces a radio frequency transmission quadrupole collision cooling focusing technology into the time-of-flight mass spectrometer, and has good effects on improving ion transmission efficiency and enhancing instrument sensitivity as an ion transmission system. When the radio frequency transmission quadrupole works, a radio frequency high-voltage electric field with specific frequency and amplitude is required to be added, and aiming at ions with different mass numbers and mass ranges, the added frequency band and amplitude have great difference, so that the control method and technology of the radio frequency high-voltage power supply electric field have high requirements.
However, in the existing time-of-flight mass spectrometers, for the radio frequency transmission quadrupole, to achieve the ion transmission from low mass number ions to high mass number ions in an extremely wide mass range, especially the ion transmission from low mass number within 20 to high mass number above 4500, a radio frequency high voltage electric field flexibly matched with different frequency bands is generated, so that the good ion transmission efficiency and instrument sensitivity in a wide mass range, as well as self-adaption degree and stability are achieved, no mature method scheme exists, and the application field of the instrument is also greatly limited.
Disclosure of Invention
Based on the above, it is necessary to provide a radio frequency transmission quadrupole power supply circuit, a control method thereof and a power supply device aiming at the problem that the application field of the traditional time-of-flight mass spectrometer is limited.
The radio frequency transmission quadrupole power supply circuit comprises a control device, a sine wave generating device, an amplifying device, a first gating device, a second gating device, a plurality of radio frequency magnetic ring transformers, radio frequency transmission quadrupole rods and a feedback adjusting device, wherein the control device is connected with the sine wave generating device, the sine wave generating device is connected with the amplifying device, the amplifying device is connected with the first gating device, the primary side of each radio frequency magnetic ring transformer is respectively connected with the first gating device, the secondary side of each radio frequency magnetic ring transformer is respectively connected with the second gating device, the second gating device is connected with the radio frequency transmission quadrupole rods, the radio frequency transmission quadrupole rods are connected with the feedback adjusting device, the feedback adjusting device is connected with the control device, the amplifying device, the first gating device, the secondary side tap of each radio frequency magnetic ring transformer and the second gating device are respectively connected with the control device.
In one embodiment, the amplifying device comprises a variable gain amplifying program-controlled amplitude modulator, an in-phase multistage amplifying circuit and an anti-phase multistage amplifying circuit, wherein the variable gain amplifying program-controlled amplitude modulator is connected with the sine wave generating device and the feedback adjusting device, the in-phase multistage amplifying circuit and the anti-phase multistage amplifying circuit are respectively connected with the variable gain amplifying program-controlled amplitude modulator, the in-phase multistage amplifying circuit and the anti-phase multistage amplifying circuit are respectively connected with the first gating device, and the in-phase multistage amplifying circuit and the anti-phase multistage amplifying circuit are respectively connected with the control device.
In one embodiment, the in-phase multistage amplification circuit comprises an in-phase amplifier, a first-stage power amplifier and a second-stage power amplifier, wherein the in-phase amplifier is connected with a variable gain amplification program-controlled amplitude modulator, the in-phase amplifier is connected with the first-stage power amplifier, the first-stage power amplifier is connected with the second-stage power amplifier, the second-stage power amplifier is connected with the first gating device, the in-phase amplifier, the first-stage power amplifier and the second-stage power amplifier are respectively connected with the control device, and/or the inverting multistage amplification circuit comprises an inverting amplifier, a first-stage amplifier and a second-stage amplifier, the inverting amplifier is connected with the variable gain amplification program-controlled amplitude modulator, the inverting amplifier is connected with the first-stage amplifier, the first-stage amplifier is connected with the second-stage amplifier, the second-stage amplifier is connected with the first gating device, and the inverting amplifier, the first-stage amplifier and the second-stage amplifier are respectively connected with the control device.
In one embodiment, the control device comprises a main controller, a power supply and current monitor, a gating controller and a medium-low voltage generator, wherein the main controller is connected with the sine wave generating device, the feedback adjusting device is connected with the main controller, the power supply and current monitor, the gating controller and the medium-low voltage generator are respectively connected with the main controller, the power supply and current monitor is connected with the amplifying device, the gating controller is connected with the first gating device and the second gating device, and the medium-low voltage generator is connected with a secondary side tap of each radio frequency magnetic ring transformer.
In one embodiment, the feedback adjustment device comprises a detection circuit, an amplitude monitor, a digital-analog controller and a proportional-integral regulator, wherein the detection circuit is connected with the radio frequency transmission quadrupole, the detection circuit is connected with the proportional-integral regulator and the amplitude monitor, the amplitude monitor and the digital-analog controller are respectively connected with the control device, the digital-analog controller is connected with the proportional-integral regulator, and the proportional-integral regulator is connected with the amplifying device.
The control method of the radio frequency transmission quadrupole rod power supply circuit comprises the steps of obtaining a frequency set value, controlling the first gating device and the second gating device to gate the corresponding radio frequency magnetic ring transformer according to the frequency set value, and obtaining the resonance frequency of the radio frequency transmission quadrupole rod power supply circuit when the minimum power consumption is achieved by adjusting the sine wave generating device and the feedback adjusting device.
In one embodiment, the radio frequency magnetic ring transformer comprises a low-frequency radio frequency magnetic ring transformer, a medium-frequency radio frequency magnetic ring transformer and a high-frequency radio frequency magnetic ring transformer, and the step of controlling the first gating device and the second gating device to gate the corresponding radio frequency magnetic ring transformer according to the frequency set value comprises the steps of comparing and analyzing according to the frequency set value and a preset first frequency range, controlling the first gating device and the second gating device to gate the low-frequency radio frequency magnetic ring transformer when the frequency set value is in the preset first frequency range, comparing and analyzing according to the frequency set value and a preset second frequency range when the frequency set value is not in the preset first frequency range, controlling the first gating device and the second gating device to gate the medium-frequency magnetic ring transformer when the frequency set value is in the preset second frequency range, comparing and analyzing according to the frequency set value and the frequency set value when the frequency set value is not in the preset first frequency range, and the minimum threshold value of the preset second frequency range is equal to the maximum threshold of the preset first frequency range, and controlling the first gating device and the second gating device to gate the medium-frequency magnetic ring transformer when the frequency set value is not in the preset second frequency range, and the second frequency set value is in the preset second frequency range, and the third gating device is in the preset second frequency range, and the maximum threshold value is compared with the first frequency range and the second frequency range.
In one embodiment, the step of obtaining the resonant frequency of the radio frequency transmission quadrupole power circuit when the minimum power consumption is achieved by adjusting the sine wave generating device and the feedback adjusting device comprises the steps of adjusting the sine wave generating device and the feedback adjusting device, collecting the current value of the amplifying device in real time, and reading the current frequency of the sine wave generating device when the minimum current value of the amplifying device is obtained, namely the resonant frequency of the radio frequency transmission quadrupole power circuit when the minimum power consumption is achieved.
The radio frequency transmission quadrupole rod power supply device comprises the radio frequency transmission quadrupole rod power supply circuit, and the control device is used for scanning to obtain the resonant frequency with the minimum power consumption according to the control method.
In one embodiment, the radio frequency transmission quadrupole rod power supply device further comprises a case, the control device, the sine wave generating device and the feedback adjusting device are integrally arranged on the same main control board card, the amplifying device, the first gating device, the second gating device and the radio frequency magnetic ring transformers are integrally arranged on the same power amplification board card, and the main control board card and the power amplification board card can be inserted and pulled out to be arranged on the case.
When the radio frequency transmission quadrupole power supply circuit, the control method and the power supply equipment start to work, the control device firstly controls the sine wave generating device to generate corresponding sine wave signals, the sine wave signals and signals fed back by the feedback adjusting device are amplified by the amplifying device, and finally the corresponding radio frequency magnetic ring transformers connected under the gating of the control device, the first gating device and the second gating device are loaded to the radio frequency transmission quadrupole, and a radio frequency high-voltage electric field is generated at the radio frequency transmission quadrupole. According to the scheme, the radio frequency magnetic ring transformers are arranged, when the ion transmission in different mass ranges and different mass numbers is carried out, the first gating device and the second gating device can correspondingly gate the different radio frequency magnetic ring transformers, so that the ion transmission from low-mass-number ions to high-mass-number ions in an extremely wide mass range can be realized, radio frequency high-voltage electric fields flexibly matched in different frequency ranges are generated, the good ion transmission efficiency in the wide mass range and the instrument sensitivity are achieved, meanwhile, a closed loop control architecture is realized through the feedback adjusting device, the radio frequency transmission quadrupole power supply circuit has extremely high self-adaption degree and stability, and the application range of the mass spectrometer can be greatly improved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments or the conventional techniques of the present application, the drawings required for the descriptions of the embodiments or the conventional techniques will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present application, and other drawings may be obtained according to the drawings without inventive effort for those skilled in the art.
FIG. 1 is a schematic diagram of a power circuit of a quadrupole rod for RF transmission in an embodiment;
FIG. 2 is a schematic diagram of a power circuit of a quadrupole rod for RF transmission in another embodiment;
FIG. 3 is a schematic diagram of a part of an amplifying device according to an embodiment;
FIG. 4 is a flow chart of a control method of the quadrupole power circuit for RF transmission according to an embodiment;
FIG. 5 is a flow chart of a control method of a quadrupole power circuit for RF transmission in another embodiment;
FIG. 6 is a schematic diagram of a gating control flow in an embodiment;
FIG. 7 is a schematic diagram of a resonant frequency scanning flow in an embodiment;
fig. 8 is a schematic structural diagram of a quadrupole power device for rf transmission in an embodiment.
Detailed Description
In order that the application may be readily understood, a more complete description of the application will be rendered by reference to the appended drawings. Preferred embodiments of the present application are shown in the drawings. This application may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Referring to fig. 1, a radio frequency transmission quadrupole power circuit includes a control device 10, a sine wave generating device 20, an amplifying device 30, a first gating device 40, a second gating device 60, a plurality of radio frequency magnetic ring transformers 50, a radio frequency transmission quadrupole 70 and a feedback adjusting device 80, wherein the control device 10 is connected with the sine wave generating device 20, the sine wave generating device 20 is connected with the amplifying device 30, the amplifying device 30 is connected with the first gating device 40, primary sides of the radio frequency magnetic ring transformers 50 are respectively connected with the first gating device 40, secondary sides of the radio frequency magnetic ring transformers 50 are respectively connected with the second gating device 60, the second gating device 60 is connected with the radio frequency transmission quadrupole 70, the radio frequency transmission quadrupole 70 is connected with the feedback adjusting device 80, the feedback adjusting device 80 is connected with the control device 10, the feedback adjusting device 80 is connected with the amplifying device 30, the first gating device 40, secondary side taps (not shown) of the radio frequency magnetic ring transformers 50 and the second gating device 60 are respectively connected with the control device 10.
Specifically, the sine wave generating device 20, that is, the DDS sine wave signal generator, can generate sine wave signals with different frequencies by the sine wave generating device 20 under the action of the control device 10. In one embodiment, the sine wave generator 20 is operable to generate sine wave signals in three different frequency bands, a high frequency band, a medium frequency band, and a low frequency band, depending on the time-of-flight mass spectrometer operating requirements using the rf transmission quadrupole rods 70. Meanwhile, in the radio frequency transmission quadrupole power supply circuit of the embodiment, a plurality of radio frequency magnetic ring transformers 50 with different frequency ranges are arranged, under the action of the control device 10 and the first gating device 40, the primary side access circuit of the radio frequency magnetic ring transformer 50 with the corresponding required frequency range can be selected, and under the action of the control device 10 and the second gating device 60, the secondary side access circuit of the radio frequency magnetic ring transformer 50 with the corresponding required frequency range can be selected. Therefore, one of the radio frequency transmission quadrupole rod power supply circuit access circuits is gated to work so as to meet the requirements of ions in different mass ranges, and further, the ion transmission from low mass numbers within 20 to high mass numbers above 4500 can be realized.
Meanwhile, the scheme of the embodiment adopts an amplitude closed-loop feedback control loop on hardware, the output waveform of the radio frequency transmission quadrupole 70 can be acquired in real time through the feedback adjusting device 80 for feedback adjustment, when the amplitude of the radio frequency high voltage applied to the radio frequency transmission quadrupole fluctuates, the amplitude is compensated back through feedback, so that the radio frequency high voltage applied to the radio frequency transmission quadrupole is ensured to be stable continuously and not to be disturbed, the amplitude stability is within 0.1%, and a stable and constant radio frequency electric field is formed. The secondary taps of each rf magnetic ring transformer 50 are respectively connected to the control device 10, so that a dc bias voltage can be generated by the control device 10 and applied to the middle tap end of the secondary side of the coil of the rf magnetic ring transformer 50, thereby providing a dc bias reference voltage for the rf ac high voltage generated by the secondary side coil of the rf magnetic ring transformer 50.
It should be noted that the specific types of the first gating device 40 and the second gating device 60 are not exclusive, and are intended to enable different paths of the rf magnetic ring transformer 50 to be connected to the circuit under the action of the control device 10. For example, in one embodiment, both the first gating device 40, the second gating device 60 may be implemented using relays, wherein the first gating device 40 may be implemented using power relays in particular, and the second gating device 60 may be implemented using high voltage relays in particular.
Referring to fig. 2, in one embodiment, the amplifying device 30 includes a variable gain amplifying programmable modulator 31, an in-phase multistage amplifying circuit 32 and an inverse multistage amplifying circuit 33, the variable gain amplifying programmable modulator 31 is connected to the sine wave generating device 20 and the feedback adjusting device 80, the in-phase multistage amplifying circuit 32 and the inverse multistage amplifying circuit 33 are respectively connected to the variable gain amplifying programmable modulator 31, the in-phase multistage amplifying circuit 32 and the inverse multistage amplifying circuit 33 are respectively connected to the first gating device 40, and the in-phase multistage amplifying circuit 32 and the inverse multistage amplifying circuit 33 are respectively connected to the control device 10.
Specifically, the variable gain amplification program-controlled modulator 31 may perform amplitude modulation, which is connected to the sine wave generating device 20 and the feedback adjusting device 80, and is capable of receiving the sine carrier signal of the sine wave generating device 20 and modulating the feedback signal fed back by the feedback adjusting device 80. The modulated amplitude-modulated wave is divided into two paths, the phases of the two paths of sine wave signals are 180 degrees different, one path of the two paths of sine wave signals is subjected to in-phase power amplification through the in-phase multistage amplification circuit 32, and the other path of the two paths of sine wave signals is subjected to anti-phase power amplification through the anti-phase multistage amplification circuit 33. Then, the controller controls the first gating device 40 to perform gating, and selects a corresponding radio frequency magnetic ring transformer 50 of the radio frequency magnetic ring transformers 50 to be connected to the circuit, so that two amplified sine wave signals with 180-degree phase difference are respectively input from two ends of a primary side coil of the radio frequency magnetic ring transformer 50, pass through two ends of a secondary coil (namely a secondary side winding) of the radio frequency magnetic ring transformer 50 and the second gating device 60, and finally are loaded to the radio frequency transmission quadrupole 70.
It will be understood that, in order to ensure that the rf transmission quadrupole 70 can generate an rf high-voltage electric field, two sine wave signals output after passing through the second gating device 60 are respectively loaded onto any two adjacent rods (the first group of adjacent rods) of the rf transmission quadrupole 70, and the two adjacent rods of the rf transmission quadrupole 70 are connected and conducted, so that the two sine wave signals can be respectively output through the other group of adjacent rods. According to the scheme of the embodiment, a multistage power amplification circuit architecture is adopted for ions with different frequency bands and different mass ranges, and the high-frequency high-voltage amplitude driving capability is achieved.
It should be noted that the specific structures of the in-phase multistage amplification circuit 32 and the inverting multistage amplification circuit 33 are not exclusive, and in one embodiment, referring to fig. 2, the in-phase multistage amplification circuit 32 includes an in-phase amplifier 321, a first-stage power amplifier 322, and a second-stage power amplifier 333, the in-phase amplifier 321 is connected to the variable gain amplification program-controlled amplitude modulator 31, the in-phase amplifier 321 is connected to the first-stage power amplifier 322, the first-stage power amplifier 322 is connected to the second-stage power amplifier 323, the second-stage power amplifier 323 is connected to the first gating device 40, the in-phase amplifier 321, the first-stage power amplifier 322, and the second-stage power amplifier 323 are respectively connected to the control device 10, and/or the inverting multistage amplification circuit 33 includes an inverting amplifier 331, a first-stage amplifier 332, and a second-stage amplifier 333, the inverting amplifier 331 is connected to the variable gain amplification program-controlled amplitude modulator 31, the inverting amplifier 331 is connected to the first-stage amplifier 332, the second-stage amplifier 333, the second-stage power amplifier 333 is connected to the first-stage amplifier 333, the first-stage amplifier 333 is connected to the inverting amplifier 321, the first-stage amplifier 40 is connected to the first-stage amplifier 40, and the first-stage gating device 10 is respectively connected to the second-stage gating device 333.
Specifically, in the scheme of this embodiment, two paths of sine wave signals output by the variable gain amplification program-controlled modulator 31, one path of sine wave signals is amplified by the in-phase amplifier 321, the first-stage power amplifier 322 and the second-stage power amplifier 323 to output an in-phase power amplified sine wave, one path of sine wave signals is amplified by the inverting amplifier 331, the first-stage amplifier 332 and the second-stage amplifier 333 to output an inverting power amplified sine wave, and the phases of the two paths of sine wave signals are 180 ° different. The two ends of the primary side coil of the corresponding conducted radio frequency magnetic ring transformer 50 are loaded after being gated by a power relay (namely, a first gating device 40), the two ends of the secondary side coil of the radio frequency magnetic ring transformer 50 are boosted by the turn ratio of the radio frequency magnetic ring transformer 50, two paths of radio frequency high-voltage sine waves with 180-degree phase difference are output by the two ends of the secondary side coil of the radio frequency magnetic ring transformer 50, the two paths of radio frequency high-voltage sine waves are gated by a high-voltage relay (namely, a second gating device 60) and are applied to two adjacent rods of a radio frequency transmission quadrupole rod to form a radio frequency high-voltage electric field, two groups of opposite rods of the radio frequency transmission quadrupole rod are conducted in a connecting mode, and the other group of two paths of radio frequency high-voltage sine waves are output by the adjacent rods.
The specific structures of the first stage power amplifier 322, the second stage power amplifier 323, and the first stage amplifier 332 and the second stage amplifier 333 are not exclusive, and in one embodiment, referring to fig. 3 in combination, the first stage power amplifier 322 includes a first amplifier K1, a first resistor R1, a second resistor R2, and a third resistor R3, the second stage power amplifier 323 includes a first switching tube Q1 and a second switching tube Q2, the first stage amplifier 332 includes a second amplifier K2, a fourth resistor R4, a fifth resistor R5, and a sixth resistor R6, and the second stage amplifier 333 includes a third switching tube Q3 and a fourth switching tube Q4; one end of the first resistor R1 is connected with the forward input end of the first amplifier K1, the other end of the first resistor R1 is connected with the in-phase amplifier 321, the reverse input end of the first resistor K1 is connected with one end of the second resistor R2 and one end of the third resistor R3, the other end of the second resistor R2 is grounded, the other end of the third resistor R3 is connected with the output end of the first amplifier K1, the control end of the first switching tube Q1 and the control end of the second switching tube Q2, the first end of the first switching tube Q1 is connected with a power supply, the second end of the first switching tube Q1 is connected with the first end of the second switching tube Q2 and a first gating device 40 (not shown), the second end of the second switching tube Q2 is connected with the power supply, one end of the fourth resistor R4 is connected with the forward input end of the second amplifier K2, the other end of the fourth resistor R4 is connected with the inverting amplifier 331, the reverse input end of the second resistor R2 is connected with one end of the fifth resistor R5 and one end of the sixth resistor R6, the other end of the fifth resistor R5 is connected with the other end of the third resistor R6, the other end of the fourth resistor R5 is connected with the third end of the fourth switching tube Q3 and the third end of the fourth switching tube Q3 is connected with the control end of the fourth switching tube Q3, a second end of the third switching tube Q3 is connected to the first end of the fourth switching tube Q4 and the first gating device 40, and a second end of the fourth switching tube Q4 is connected to a power supply.
Specifically, the sine wave in-phase signal VIN1 output by the in-phase amplifier 321 and the sine wave opposite-phase signal VIN2 output by the opposite-phase amplifier 331 are amplified by the same proportion by the first-stage high-speed power operational amplifier (i.e. the first amplifier K1 and the second amplifier K2), respectively enter the dual-power common-collector triode complementary push-pull power amplifier circuits in the second-stage power amplifier 323 and the second-stage amplifier 333, output sine wave power signals with good current driving and voltage driving capability in the in-phase and opposite-phase two paths, and are respectively added to two ends of the primary side of the corresponding radio-frequency magnetic ring transformer 50 after being gated, and the adopted radio-frequency magnetic ring can have extremely low loss and boost amplification factor at the resonance point of the radio-frequency band. Through the primary power amplifier, the secondary power amplifier and the special radio frequency magnetic ring transformer 50, the secondary side of the coil of the radio frequency magnetic ring transformer 50 can output radio frequency high voltage with very high amplitude, and the radio frequency high voltage requirements of ions with different mass numbers in different frequency bands can be well met.
It should be noted that in one embodiment, the rf magnetic ring transformer 50 uses a transformer coil of a special material to ensure the operational reliability of the rf magnetic ring transformer 50, which may be specifically a carbonyl iron powder magnetic core material.
Referring to fig. 2, in one embodiment, the control device 10 includes a main controller 11, a power supply and current monitor 12, a gate controller 13, and a low-medium voltage generator 14, the main controller 11 is connected to the sine wave generating device 20, a feedback regulator 80 is connected to the main controller 11, the power supply and current monitor 12, the gate controller 13, and the low-medium voltage generator 14 are respectively connected to the main controller 11, the power supply and current monitor 12 is connected to the amplifying device 30, the gate controller 13 is connected to the first gate device 40 and the second gate device 60, and the low-medium voltage generator 14 is connected to the secondary side tap of each rf magnetic ring transformer 50.
Specifically, the control device 10 includes a main controller 11 for implementing a main control function, a power supply and current monitor 12 for monitoring the power supply and current of the amplifying device 30, a gating controller 13 for controlling the first gating device 40 and the second gating device 60 to operate in corresponding channels, and a medium-low voltage generator 14 for providing a direct current bias voltage to taps of secondary windings of the respective radio frequency magnetic ring transformers 50. When the radio frequency transmission quadrupole power supply circuit is started to operate, the main controller 11 sends a control instruction to the gating controller 13, so that the gating controller 13 controls the first gating device 40 and the second gating device 60 to operate in corresponding channels, the corresponding radio frequency magnetic ring transformer 50 is connected to the circuit, meanwhile, the medium-low voltage generator 14 is controlled to provide direct current bias current for the secondary coil of the radio frequency magnetic ring transformer 50, finally, a high-voltage electric field is generated at the radio frequency transmission quadrupole 70, and the current flowing through the amplifying device 30 can be collected through the power supply and current monitor 12, so that the resonant frequency of the minimum power consumption of the radio frequency transmission quadrupole power supply circuit can be rapidly and accurately scanned.
Referring to fig. 2, in one embodiment, the feedback adjustment device 80 includes a detection circuit 81, an amplitude monitor 84, a digital-to-analog controller 82, and a proportional-integral regulator 83, where the detection circuit 81 is connected to the rf transmission quadrupole 70, the detection circuit 81 is connected to the proportional-integral regulator 83 and the amplitude monitor 84, the amplitude monitor 84 and the digital-to-analog controller 82 are respectively connected to the control device 10, the digital-to-analog controller 82 is connected to the proportional-integral regulator 83, and the proportional-integral regulator 83 is connected to the amplifying device 30.
Specifically, after the two paths of radio frequency high-voltage sine waves output by the radio frequency transmission quadrupole 70 are collected and analyzed by the detection circuit 81, output feedback signals are added to the proportional integral regulator 83 (PI regulator), and are subjected to error comparison and amplification through PI regulation together with control signals generated by the main controller 11 through DA control (namely, the digital-analog controller 82), so that hardware closed-loop negative feedback is formed, and finally, signals output by the PI regulator are fed back to the amplifying device 30, and the amplitude of the radio frequency high-voltage sine waves is subjected to compensation control in real time, so that the stability and the constancy of the amplitude are ensured. Meanwhile, the feedback signal output by the detection circuit 81 is also returned to the main controller 11 through the amplitude monitor 84 for amplitude real-time monitoring, thereby forming a complete hardware closed feedback control loop.
When the radio frequency transmission quadrupole power supply circuit starts to work, the control device 10 firstly controls the sine wave generating device 20 to generate corresponding sine wave signals, the sine wave signals and signals fed back by the feedback adjusting device 80 are amplified by the amplifying device 30, and finally the corresponding radio frequency magnetic ring transformers 50 which are connected under the gating of the control device 10, the first gating device 40 and the second gating device 60 are loaded to the radio frequency transmission quadrupole 70, so that a radio frequency high-voltage electric field is generated at the radio frequency transmission quadrupole 70. In the above scheme, a plurality of different rf magnetic ring transformers 50 are provided, and when ions with different mass ranges and different mass numbers are transmitted, the first gating device 40 and the second gating device 60 can correspondingly gate different rf magnetic ring transformers 50, so that the ion transmission from ions with low mass numbers to ions with high mass numbers can be realized, the rf high-voltage electric field flexibly matched with different frequency ranges can be generated, the good ion transmission efficiency and instrument sensitivity with wide mass ranges can be achieved, and meanwhile, the feedback adjusting device 80 realizes a closed-loop control architecture, so that the rf transmission quadrupole power circuit has extremely high self-adaptation degree and stability, and the application range of the mass spectrometer can be greatly improved.
Referring to fig. 4, a control method of the radio frequency transmission quadrupole power circuit includes steps S100, S200 and S300.
Step S100, obtaining a frequency set value, step S200, controlling a first gating device and a second gating device to gate a corresponding radio frequency magnetic ring transformer according to the frequency set value, and step S300, obtaining the resonant frequency of the radio frequency transmission quadrupole rod power supply circuit during minimum power consumption by adjusting a sine wave generating device and a feedback adjusting device.
Specifically, as shown in the above embodiments and the drawings, the specific structure of the radio frequency transmission quadrupole power supply circuit provided by the application adopts a frequency scanning program algorithm with a wide frequency range and fine stepping when the radio frequency transmission quadrupole power supply circuit is started to work, and under different frequency segments, the resonant frequency with the minimum power consumption can be rapidly and accurately scanned by one key for the radio frequency transmission quadrupole with different effective capacitances and the matched inductance coil on the secondary side of the radio frequency magnetic ring transformer 50. First, the control device 10 acquires a frequency setting value, which may be directly input into the control device 10 by a user, or may be transmitted through a host computer or a user terminal connected to the control device 10.
And then the control device 10 correspondingly controls the first gating device 40 and the second gating device 60 to gate different radio frequency magnetic ring transformers 50 according to the received set frequency, and finally scans to obtain the resonant frequency with the minimum power consumption by continuously adjusting the input of the amplifying device 30, so that the radio frequency transmission quadrupole rod power supply circuit has good self-adaption capability.
The manner in which the resonant frequency is scanned is not unique, referring to fig. 5, in one embodiment, step S300 includes step S310 and step S320.
Step S310, adjusting the sine wave generating device and the feedback adjusting device, and collecting the current value of the amplifying device in real time, and step S320, when the minimum current value of the amplifying device is obtained, reading the current frequency of the sine wave generating device, namely the resonant frequency when the radio frequency transmission quadrupole power supply circuit is at minimum power consumption.
Specifically, when the control device 10 adjusts the sine wave generating device 20 and the feedback adjusting device 80, the corresponding signals applied to the amplifying device 30 will also change, and at this time, the control device 10 may analyze the current signal collected and transmitted by the current monitor 12 through the received power supply, and when obtaining the minimum current signal, the frequency corresponding to the minimum current signal may be regarded as the resonant frequency.
Referring to fig. 6, in one embodiment, the rf magnetic ring transformer 50 includes a low-band rf magnetic ring transformer 50, a medium-band rf magnetic ring transformer 50, and a high-band rf magnetic ring transformer 50, and step S200 includes steps S210, S220, S230, S240, S250, and S260.
The method comprises the steps of S210 comparing and analyzing according to a frequency set value with a preset first frequency range, S220 controlling a first gating device and a second gating device to gate a low-frequency-band radio-frequency magnetic ring transformer when the frequency set value is in the preset first frequency range, S230 comparing and analyzing according to the frequency set value and the preset second frequency range when the frequency set value is not in the preset first frequency range, S240 controlling the first gating device and the second gating device to gate the medium-frequency-band radio-frequency magnetic ring transformer when the frequency set value is in the preset second frequency range, S250 comparing and analyzing according to the frequency set value and the preset third frequency range when the frequency set value is not in the preset second frequency range, S260 controlling the first gating device and the second gating device to gate the high-frequency-band radio-frequency magnetic ring transformer when the frequency set value is in the preset third frequency range.
Specifically, referring to fig. 7 in combination, the rf transmission quadrupole power circuit is powered on to perform system initialization, and the control device 10 first reads the Freg set frequency value (i.e. the frequency set value) sent by the upper computer, and starts to determine whether the set frequency value is within a preset first frequency range, i.e. between FS1 and FE1 frequencies. If the judgment result is yes, the gating channel 1 is opened, the power relay (the first gating device 40) and the high-voltage relay (the second gating device 60) gate the first path, and the low-frequency radio-frequency magnetic ring transformer 50 is conducted. The output of the digital-analog controller 82 (DAC) in the feedback regulator 80 and the output of the DDS frequency (i.e. the sine wave generator 20) can be adjusted continuously and finely, the power supply of the controller 10 and the current monitor 12 are used for current signal acquisition, the minimum current value of the amplifying device 30 is searched circularly, and when the minimum current value is found finally, the current actual frequency value Freg is read. Judging whether the frequency value is in a preset first frequency range, if so, judging that the matched resonant frequency in the preset first frequency range is found, and ending the frequency scanning, and if not, judging that the load connection of the radio frequency transmission quadrupole rods has errors, and ending the program.
If the set frequency value is not within the preset first frequency range, then judging whether the set frequency value is within the preset second frequency range, namely, whether the set frequency value is between the FS2 and FE2 frequencies. If so, the gating channel 2 is opened, the power relay and the high-voltage relay gate the second path, the medium-frequency radio-frequency magnetic ring transformer 50 is conducted, the DDS frequency output is output and regulated by the continuous fine stepping regulation integral mode controller 82, the current signal acquisition is carried out by the power supply and current monitor 12 of the control device 10, the minimum current value of the amplifying device 30 is searched circularly, and when the minimum current value is finally found, the current actual frequency value Freg is read. Judging whether the frequency value is in a preset second frequency range, if so, judging that the matched resonant frequency in the preset second frequency range is found, and ending the frequency scanning, and if not, judging that the load connection of the radio frequency transmission quadrupole rods has errors, and ending the program.
If the set frequency value is still not within the preset second frequency range, then it is determined whether the set frequency is within the preset third frequency range, i.e. between the FS3 and FE3 frequencies. If so, the gating channel 3 is opened, the power relay and the high-voltage relay gate the third path, the high-frequency radio-frequency magnetic ring transformer 50 is conducted, the DAC output is continuously and finely adjusted, the DDS frequency output is adjusted, the power supply of the control device 10 and the current monitor 12 are used for current signal acquisition, the minimum current value of the amplifying device 30 is circularly searched, and when the minimum current value is finally found, the current actual frequency value Freg is read. Judging whether the frequency value is in a preset third frequency range, if so, judging that the matched resonant frequency in the preset third frequency range is found, and ending the frequency scanning, and if not, judging that the load connection of the radio frequency transmission quadrupole rods is wrong, ending the program, so that the quick and accurate resonant frequency scanning is realized in the moment of power-on.
It should be noted that the relation among the preset first frequency band range, the preset second frequency band range, and the preset third frequency band range is that fs1< fe1=fs2 < fe2=fs3 < FE3. In one embodiment, when the power supply of the control device 10 and the current monitor 12 perform current signal acquisition, the minimum current value of the amplifying device 30 may be searched for one minute in a circulating manner, and the lowest current value in the one minute is taken as the minimum current value of the amplifying device 30, so as to realize rapid and accurate resonant frequency scanning.
According to the control method of the radio frequency transmission quadrupole power supply circuit, a frequency scanning program algorithm with a wide frequency range and fine stepping is adopted, and automatic, rapid and accurate scanning of high-voltage flexible switching gating and resonance frequency of radio frequencies of three frequency bands of high, medium and low is realized aiming at transmission quadrupole with different capacitance characteristics.
The radio frequency transmission quadrupole power supply device comprises the radio frequency transmission quadrupole power supply circuit, and the control device 10 is used for scanning to obtain the resonant frequency with minimum power consumption according to the control method.
Specifically, the specific structure of the radio frequency transmission quadrupole power supply circuit is that the sine wave generating device 20, namely a DDS sine wave signal generator, is shown in the above embodiments and the drawings, and sine wave signals with different frequencies can be generated by the sine wave generating device 20 under the action of the control device 10. In one embodiment, the sine wave generator 20 is operable to generate sine wave signals in three different frequency bands, a high frequency band, a medium frequency band, and a low frequency band, depending on the time-of-flight mass spectrometer operating requirements using the rf transmission quadrupole rods 70. Meanwhile, in the radio frequency transmission quadrupole power supply circuit of the embodiment, a plurality of radio frequency magnetic ring transformers 50 with different frequency ranges are arranged, under the action of the control device 10 and the first gating device 40, the primary side access circuit of the radio frequency magnetic ring transformer 50 with the corresponding required frequency range can be selected, and under the action of the control device 10 and the second gating device 60, the secondary side access circuit of the radio frequency magnetic ring transformer 50 with the corresponding required frequency range can be selected. Therefore, one of the radio frequency transmission quadrupole rod power supply circuit access circuits is gated to work so as to meet the requirements of ions in different mass ranges, and further, the ion transmission from low mass numbers within 20 to high mass numbers above 4500 can be realized.
Meanwhile, the scheme of the embodiment adopts an amplitude closed-loop feedback control loop on hardware, the output waveform of the radio frequency transmission quadrupole 70 can be acquired in real time through the feedback adjusting device 80 for feedback adjustment, when the amplitude of the radio frequency high voltage applied to the radio frequency transmission quadrupole fluctuates, the amplitude is compensated back through feedback, so that the radio frequency high voltage applied to the radio frequency transmission quadrupole is ensured to be stable continuously and not to be disturbed, the amplitude stability is within 0.1%, and a stable and constant radio frequency electric field is formed. The secondary taps of each rf magnetic ring transformer 50 are respectively connected to the control device 10, so that a dc bias voltage can be generated by the control device 10 and applied to the middle tap end of the secondary side of the coil of the rf magnetic ring transformer 50, thereby providing a dc bias reference voltage for the rf ac high voltage generated by the secondary side coil of the rf magnetic ring transformer 50.
When the radio frequency transmission quadrupole power circuit is started to work, a frequency scanning program algorithm with a wide frequency range and fine stepping is adopted, and under different frequency segments, the resonance frequency with minimum power consumption can be rapidly and accurately scanned by one key aiming at the radio frequency transmission quadrupole with different equivalent capacitances and the inductance coil on the secondary side of the matched radio frequency magnetic ring transformer 50. First, the control device 10 acquires a frequency setting value, which may be directly input into the control device 10 by a user, or may be transmitted through a host computer or a user terminal connected to the control device 10.
And then the control device 10 correspondingly controls the first gating device 40 and the second gating device 60 to gate different radio frequency magnetic ring transformers 50 according to the received set frequency, and finally scans to obtain the resonant frequency with the minimum power consumption by continuously adjusting the input of the amplifying device 30, so that the radio frequency transmission quadrupole rod power supply circuit has good self-adaption capability.
In one embodiment, the radio frequency transmission quadrupole power supply device further includes a chassis, the control device 10, the sine wave generating device 20 and the feedback adjusting device 80 are integrally disposed on the same main control board card, the amplifying device 30, the first gating device 40, the second gating device 60 and the plurality of radio frequency magnetic ring transformers 50 are integrally disposed on the same power amplifier board card, and the main control board card and the power amplifier board card are pluggable and disposed on the chassis.
Specifically, in this embodiment, for convenience of understanding, please refer to fig. 8, in a more detailed embodiment, the number of the power amplifier boards is two, that is, the first power amplifier board 500 and the second power amplifier board 600, and the two power amplifier boards are two boards with identical structures and functions, wherein the windings of the rf magnetic ring transformer 50 are different to generate different high-voltage electric fields for different rf transmission quadrupoles. The main control board 400, the first power amplifier board 500 and the second power amplifier board 600 can be quickly inserted into and pulled out of the chassis 700. The main control board 400 communicates with the outside and provides control signals for the first power amplification board 500 and the second power amplification board 600, the first power amplification board 500 provides a radio frequency high voltage electric field for the first group of radio frequency transmission quadrupole rods, and the second power amplification board 600 provides a radio frequency high voltage electric field for the second group of radio frequency transmission quadrupole rods. According to different radio frequency transmission quadrupole rod demands, the first power amplification board card 500 and the second power amplification board card 600 can realize rapid custom design and random plug replacement, and meanwhile, maintenance can be more convenient.
According to the radio frequency transmission quadrupole rod power supply device, the integrated mechanical structure of the plug-in card module is adopted, so that each functional module can be rapidly customized, designed, maintained and replaced according to different radio frequency transmission quadrupole rod requirements, and the radio frequency transmission quadrupole rod power supply device has high operation convenience.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples illustrate only a few embodiments of the application, which are described in detail and are not to be construed as limiting the scope of the claims. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the application, which are all within the scope of the application. Accordingly, the scope of protection of the present application is to be determined by the appended claims.
Claims (10)
1. A radio frequency transmission quadrupole rod power supply circuit is characterized by comprising a control device, a sine wave generating device, an amplifying device, a first gating device, a second gating device, a plurality of radio frequency magnetic ring transformers, radio frequency transmission quadrupole rods and a feedback regulating device,
The control device is connected with the sine wave generating device, the sine wave generating device is connected with the amplifying device, the amplifying device is connected with the first gating devices, primary sides of the radio frequency magnetic ring transformers are respectively connected with the first gating devices, secondary sides of the radio frequency magnetic ring transformers are respectively connected with the second gating devices, the second gating devices are connected with the radio frequency transmission quadrupole rods, the radio frequency transmission quadrupole rods are connected with the feedback adjusting device, the feedback adjusting device is connected with the control device, the feedback adjusting device is connected with the amplifying device, and the amplifying device, the first gating devices, secondary side taps of the radio frequency magnetic ring transformers and the second gating devices are respectively connected with the control device.
2. The radio frequency transmission quadrupole power supply circuit according to claim 1, wherein the amplifying device comprises a variable gain amplification program-controlled amplitude modulator, an in-phase multistage amplifying circuit and an anti-phase multistage amplifying circuit, the variable gain amplification program-controlled amplitude modulator is connected with the sine wave generating device and the feedback adjusting device, the in-phase multistage amplifying circuit and the anti-phase multistage amplifying circuit are respectively connected with the variable gain amplification program-controlled amplitude modulator, the in-phase multistage amplifying circuit and the anti-phase multistage amplifying circuit are respectively connected with the first gating device, and the in-phase multistage amplifying circuit and the anti-phase multistage amplifying circuit are respectively connected with the control device.
3. The radio frequency transmission quadrupole power circuit of claim 2, wherein the in-phase multistage amplification circuit comprises an in-phase amplifier, a first stage power amplifier and a second stage power amplifier, the in-phase amplifier is connected to a variable gain amplification programmable amplitude modulator, the in-phase amplifier is connected to the first stage power amplifier, the first stage power amplifier is connected to the second stage power amplifier, the second stage power amplifier is connected to the first gating device, the in-phase amplifier, the first stage power amplifier and the second stage power amplifier are respectively connected to the control device, and/or,
The inverting multistage amplification circuit comprises an inverting amplifier, a first-stage amplifier and a second-stage amplifier, wherein the inverting amplifier is connected with a variable gain amplification program-controlled amplitude modulator, the inverting amplifier is connected with the first-stage amplifier, the first-stage amplifier is connected with the second-stage amplifier, the second-stage amplifier is connected with the first gating device, and the inverting amplifier, the first-stage amplifier and the second-stage amplifier are respectively connected with the control device.
4. A radio frequency transmission quadrupole power circuit according to any one of claims 1-3, wherein the control means comprises a main controller, a power supply and current monitor, a gating controller and a medium-low voltage generator, the main controller being connected to the sine wave generating means, the feedback adjusting means being connected to the main controller, the power supply and current monitor, the gating controller and the medium-low voltage generator being connected to the main controller respectively, the power supply and current monitor being connected to the amplifying means, the gating controller being connected to the first gating device and the second gating device, the medium-low voltage generator being connected to a secondary tap of each of the radio frequency magnetic loop transformers.
5. The radio frequency transmission quadrupole power supply circuit of claim 4, wherein the feedback adjustment device comprises a detection circuit, an amplitude monitor, a digital-to-analog controller, and a proportional-integral regulator, the detection circuit is connected to the radio frequency transmission quadrupole, the detection circuit is connected to the proportional-integral regulator and the amplitude monitor, the amplitude monitor and the digital-to-analog controller are respectively connected to the control device, the digital-to-analog controller is connected to the proportional-integral regulator, and the proportional-to-integral regulator is connected to the amplifying device.
6. A method of controlling a radio frequency transmission quadrupole power circuit as set forth in any one of claims 1-5, comprising:
Acquiring a frequency set value;
Controlling the first gating device and the second gating device to gate the corresponding radio frequency magnetic ring transformer according to the frequency set value;
And the resonance frequency of the radio frequency transmission quadrupole rod power supply circuit with minimum power consumption is obtained by adjusting the sine wave generating device and the feedback adjusting device.
7. The control method according to claim 6, wherein the rf magnetic ring transformer includes a low-band rf magnetic ring transformer, a medium-band rf magnetic ring transformer, and a high-band rf magnetic ring transformer, and the step of controlling the first gating device and the second gating device to gate the corresponding rf magnetic ring transformers according to the frequency set value includes:
Comparing and analyzing the frequency set value with a preset first frequency range according to the frequency set value;
When the frequency set value is in the preset first frequency range, controlling the first gating device and the second gating device to gate the low-frequency radio-frequency magnetic ring transformer;
When the frequency set value is not in the preset first frequency range, comparing and analyzing according to the frequency set value and a preset second frequency range, wherein the minimum threshold value of the preset second frequency range is equal to the maximum threshold value of the preset first frequency range;
When the frequency set value is in the preset second frequency range, the first gating device and the second gating device are controlled to gate the medium-frequency radio-frequency magnetic ring transformer;
When the frequency set value is not in the preset second frequency range, comparing and analyzing according to the frequency set value and a preset third frequency range, wherein the minimum threshold value of the preset third frequency range is equal to the maximum threshold value of the preset second frequency range;
And when the frequency set value is in the preset third frequency range, controlling the first gating device and the second gating device to gate the high-frequency radio-frequency magnetic ring transformer.
8. The control method according to claim 6, wherein the step of obtaining the resonance frequency at which the radio frequency transmission quadrupole power supply circuit has minimum power consumption by adjusting the sine wave generating device and the feedback adjusting device comprises:
the sine wave generating device and the feedback adjusting device are adjusted, and the current value of the amplifying device is collected in real time;
When the minimum current value of the amplifying device is obtained, the current frequency of the sine wave generating device is read, namely the resonant frequency of the radio frequency transmission quadrupole rod power supply circuit when the minimum power consumption is achieved.
9. A radio frequency transmission quadrupole power source apparatus comprising a radio frequency transmission quadrupole power circuit as claimed in any one of claims 1 to 5, the control means being arranged to scan for a resonant frequency of minimum power consumption in accordance with the control method of any one of claims 6 to 8.
10. The radio-frequency transmission quadrupole rod power equipment of claim 9, further comprising a case, wherein the control device, the sine wave generating device and the feedback adjusting device are integrally arranged on the same main control board card, the amplifying device, the first gating device, the second gating device and the plurality of radio-frequency magnetic ring transformers are integrally arranged on the same power amplification board card, and the main control board card and the power amplification board card are pluggable and arranged on the case.
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| CN202011602876.5A CN112635288B (en) | 2020-12-29 | 2020-12-29 | Radio frequency transmission quadrupole power supply circuit and control method thereof, and power supply device |
| PCT/CN2020/142339 WO2022141481A1 (en) | 2020-12-29 | 2020-12-31 | Radio frequency transmission quadrupole rod power source circuit and control method therefor, and power source device |
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| CN113285612A (en) * | 2021-06-15 | 2021-08-20 | 苏州大学 | High-frequency high-voltage power supply system of mass spectrometer |
| CN113921369A (en) * | 2021-09-29 | 2022-01-11 | 上海裕达实业有限公司 | Radio frequency power supply for mass spectrometer ion guidance and tuning method thereof |
| CN116399935B (en) * | 2021-12-27 | 2025-07-22 | 昆山禾信质谱技术有限公司 | Sweep frequency control method and related device |
| CN115085694A (en) * | 2022-05-13 | 2022-09-20 | 中国科学院苏州生物医学工程技术研究所 | Self-tuning method and system for quadrupole rod radio frequency power supply |
| CN116647095A (en) * | 2023-05-06 | 2023-08-25 | 华为技术有限公司 | Power supply circuits and electronics |
| CN116387131B (en) * | 2023-05-19 | 2023-08-08 | 翊新诊断技术(苏州)有限公司 | Quadrupole radio frequency signal generation circuit |
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| US8487249B2 (en) * | 2010-12-14 | 2013-07-16 | The Regents Of The University Of Michigan Office Of Technology Transfer | Auxiliary frequency parametric excitation of quadrupole mass spectrometers |
| CN106711010B (en) * | 2016-12-26 | 2019-01-04 | 中国科学技术大学 | A kind of mass spectrometric quadrupole guide bar radio-frequency power supply circuit |
| CN206992977U (en) * | 2017-04-12 | 2018-02-09 | 江苏可力色质医疗器械有限公司 | One kind is applied to the mass spectrometric radio-frequency power supply circuit of level Four bar |
| CN107124146A (en) * | 2017-05-03 | 2017-09-01 | 宜确半导体（苏州）有限公司 | A kind of radio-frequency power amplifier |
| CN107123585B (en) * | 2017-05-08 | 2018-11-30 | 清华大学深圳研究生院 | A kind of straight drive radio-frequency power supply |
| CN207474415U (en) * | 2017-11-27 | 2018-06-08 | 江苏天瑞仪器股份有限公司 | A kind of signal generator assists radio-frequency power supply tuner |
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