CN112618397A

CN112618397A - Rejuvenation anti-aging repair stock solution and preparation method thereof

Info

Publication number: CN112618397A
Application number: CN202110003251.5A
Authority: CN
Inventors: 鲁建军; 鲁钰; 黄政平; 曹倩文
Original assignee: Guangdong Minglan Cosmetics Manufacturing Co ltd
Current assignee: Guangdong Minglan Cosmetics Manufacturing Co ltd
Priority date: 2021-01-04
Filing date: 2021-01-04
Publication date: 2021-04-09

Abstract

The application relates to the technical field of cosmetics, and particularly discloses a rejuvenation anti-aging repairing stock solution and a preparation method thereof. The rejuvenation anti-aging repair stock solution comprises: water, a chelating agent A, a skin conditioning agent A, a solvent B, a humectant B, an antioxidant C, encapsulated azelaic acid, ellagic acid, a solvent D and an antiseptic synergist D. The preparation method comprises the following steps: step 1), weighing water, a chelating agent A and a skin conditioner A, adding the materials into a container, stirring, heating and keeping the temperature; step 2), weighing the solvent B and the humectant B, adding into a container for homogenizing, stirring, preserving heat and cooling; step 3) weighing the solvent D and the anticorrosion synergist D, adding the solvent D and the anticorrosion synergist D into a container, stirring and cooling; step 4), weighing the antioxidant C, the coated azelaic acid and the ellagic acid, adding into a container, filtering and discharging; the anti-aging and repairing stock solution for the children is easier to absorb by the skin, so that the effect of skin brightening by the adverse age is better, and meanwhile, the anti-aging and repairing stock solution can also have a sun-screening effect.

Description

Rejuvenation anti-aging repair stock solution and preparation method thereof

Technical Field

The application relates to the technical field of cosmetics, in particular to a rejuvenation anti-aging repairing stock solution and a preparation method thereof.

Background

With the passing of time and the increase of age, cells in a body begin to lose vitality, and are influenced by problems of computer radiation, ultraviolet radiation, skin aging and the like, the skin of many women becomes dark yellow and has no luster, and the reason of the dark yellow skin is that aged cells of the face are continuously deposited, so that the skin whitening and anti-aging skin care product can be used as soon as possible to effectively prevent and remove the problems of the dark yellow skin, the cell aging and the like, and more skin whitening and anti-aging skin care products appear.

At present, most of whitening anti-aging products on the market achieve the whitening anti-aging effect by resisting oxidation or enhancing the metabolic activity of skin cells and promoting the metabolic capability of skin, but only a small part of components in most whitening anti-aging skin care products can be absorbed, and the rest components are remained in the cuticle, so that the required whitening anti-aging effect cannot be achieved.

In view of the above-mentioned related technologies, the inventors believe that whitening anti-aging products are not easily absorbed by the skin and are in need of further improvement.

Disclosure of Invention

In order to better absorb whitening and anti-aging products for skin, the application provides a rejuvenation and anti-aging repairing stock solution and a preparation method thereof.

In a first aspect, the application provides a rejuvenation anti-aging repair stock solution, which adopts the following technical scheme:

the rejuvenation anti-aging repairing stock solution comprises a component A, a component B, a component C and a component D, wherein the component A comprises the following components in percentage by mass:

the balance of water;

0.01 to 0.1 percent of chelating agent A;

8% -12% of a skin conditioner A;

the component B comprises the following components in percentage by mass:

2% -5% of a solvent B;

0.1 to 0.5 percent of humectant B;

the component C comprises the following components in percentage by mass:

0.5 to 1.5 percent of antioxidant C;

wrapping azelaic acid 2-5%;

2% -5% of ellagic acid;

the component D comprises the following components in percentage by mass:

0.5 to 2 percent of solvent D;

0.01 to 0.1 percent of antiseptic synergist D.

By adopting the technical scheme, the azelaic acid is wrapped by the cyclodextrin azelaic acid, so that the water solubility is improved, the irritation is reduced, the penetration is promoted, the absorption of active ingredients is promoted while the function of the azelaic acid is kept, the wrapped azelaic acid and the ellagic acid are matched with each other, the skin-penetrating absorption is easier, the skin-whitening and flaw-lightening effects are more remarkable, the skin cutin metabolism can be promoted, the skin aging can be effectively prevented, the skin-whitening effect is better, and the sun-screening effect can be realized.

The chelating agent A can be one or more of disodium EDTA and trisodium ethylenediamine disuccinate, and the skin conditioning agent A can be one or more of nicotinamide, acetyl chitosamine, glycerol, erythritol and poly gamma-sodium glutamate;

the solvent B can be one or more of butanediol and isopropanol, and the humectant B can be one or more of sodium hyaluronate, acetylated sodium hyaluronate and hydrolyzed sodium hyaluronate;

the antioxidant C can be one or more of carnosine and hydrogenated lecithin;

the solvent D can be one or more of propylene glycol and hexylene glycol, and the preservative synergist D can be one or more of caprylyl hydroximic acid and phenoxyethanol.

Preferably, the component C also comprises the following components in percentage by mass:

1% -2% of adenosine triphosphate.

By adopting the technical scheme, the adenosine triphosphate is added to serve as energy currency in cells, so that the metabolic activity of skin cells can be enhanced, the skin metabolism is promoted, the absorption of active ingredients is promoted, the skin tenderness and smoothness can be obviously improved, the brightness is improved, the skin is whitened, and the skin brightening effect in the inverse age is better.

0.5 to 2 percent of isosorbide dimethyl ether.

By adopting the technical scheme, the isosorbide dimethyl ether is a novel high-efficiency penetration enhancer and can dissolve free fat in the skin, so that the skin is penetrated, the active ingredients enter the epidermal layer and the dermal layer at a higher concentration, the absorption of the active ingredients is further promoted, the skin is whitened, and the skin-lightening effect is further enhanced.

licorice root extract 0.1-0.5%.

By adopting the technical scheme, the liquorice root extract is added, so that the effects of promoting the activity of the skin and the like, inhibiting the formation of melanin, further enhancing the anti-aging effect and whitening and brightening the skin are achieved, and the liquorice root extract contains components with sunscreen efficacy, shows strong absorption to ultraviolet light and visible light, further enhances the sunscreen effect and can enhance the effect of whitening the skin in the inverse age.

0.5 to 1.5 percent of hydroxy pinacolone retinoic acid ester.

By adopting the technical scheme, the hydroxy pinacolone retinoic acid ester is added, is a new generation of esterified retinoic acid, has small irritation, better safety in use and more excellent skin penetration rate, can further promote skin absorption, and enhances the effects of whitening, tendering and resisting oxidation, so that the effect of skin brightening by adverse age is better.

Preferably, the skin conditioner A at least comprises the following components in percentage by mass:

4% -6% of nicotinamide;

1 to 3 percent of acetyl chitosamine.

By adopting the technical scheme, the nicotinamide and the acetyl chitosamine are matched in a specific ratio, the nicotinamide is a classic whitening and skin-tendering raw material, the acetyl chitosamine is a substance prepared by natural enzyme hydrolysis, and has whitening and repairing effects, but the combination of the nicotinamide and the acetyl chitosamine in the specific ratio has a synergistic effect, so that the effect is amplified, the melanin is lightened and inhibited, the whitening and skin-tendering effects are better, and the effect of skin lightening in the adverse age is further enhanced.

In a second aspect, the preparation method of the rejuvenation anti-aging repair stock solution provided by the application adopts the following technical scheme:

the preparation method of the rejuvenation anti-aging repairing stock solution comprises the following steps:

step 1), weighing water, a chelating agent A and a skin conditioner A according to a formula, adding the materials into a container, heating and stirring, and keeping the temperature;

step 2), weighing the solvent B and the humectant B according to the formula, adding the solvent B and the humectant B into a container, homogenizing, stirring, preserving heat and cooling;

step 3), after cooling, weighing the solvent D and the anticorrosion synergist D according to the formula, adding the solvent D and the anticorrosion synergist D into a container, stirring and cooling;

and 4) after cooling, weighing the antioxidant C, the coated azelaic acid and the ellagic acid according to the formula, adding into a container, filtering and discharging.

By adopting the technical scheme, the chelating agent A and the skin conditioner A are added into the container by adding water to be heated and stirred, the dissolving speed is accelerated, meanwhile, the stirring operation is carried out, the dissolving is further accelerated, the chemical characteristics of each component are kept by controlling the temperature, the water solubility is improved, the irritation is reduced, the permeation is promoted, the absorption of active ingredients is promoted while the functions of the azelaic acid are kept by adding the coated azelaic acid, the coated azelaic acid and the ellagic acid are matched with each other, the skin-permeable absorption is easier, the skin-whitening and skin-tendering effects are better, the oxidation resistance is enhanced, the skin aging is effectively prevented, the skin-whitening and skin-brightening effects are better, and the sun-screening effect is also achieved.

In the step 4), adenosine triphosphate, isosorbide dimethyl ether, licorice root extract and hydroxy pinacolone retinoic acid ester are also added.

By adopting the technical scheme, adenosine triphosphate, isosorbide dimethyl ether, licorice root extract and hydroxy pinacolone retinoic acid ester are added in the step 4), so that the components can effectively exert chemical properties of the components, the solubility is higher, free fat in the skin is dissolved, the components penetrate through the skin, active ingredients enter a epidermal layer and a dermal layer in a higher concentration, the absorption of the active ingredients is further promoted, the dark yellow skin is improved, the skin color is lightened, the skin is whitened and tender, the skin aging is effectively prevented, the effect of skin lightening with inverse age is achieved, the licorice root extract contains ingredients with sun protection efficacy, the ultraviolet light and visible light are strongly absorbed, the sun protection effect is enhanced, and the effect of skin lightening with inverse age is better.

In summary, the present application has the following beneficial effects:

1. the rejuvenation anti-aging repairing stock solution comprises the component A, the component B, the component C and the component D, and the azelaic acid is coated, so that the water solubility is improved, the irritation is reduced, the penetration is promoted, the absorption of active ingredients is promoted while the function of the azelaic acid is kept, and the coated azelaic acid and ellagic acid are matched with each other, so that the skin can be easily absorbed through skin, the skin cutin metabolism can be promoted, the skin aging can be effectively prevented, the skin-aging-resisting and skin-brightening effect is better, and the sunscreen effect can be realized.

2. The application preferably adds isosorbide dimethyl ether, and the addition of isosorbide dimethyl ether is a novel high-efficiency penetration enhancer, so that free fat in the skin can be dissolved, the skin can be penetrated, the active ingredients can enter a epidermal layer and a dermis layer at a higher concentration, the absorption of the active ingredients is further promoted, and the reverse skin brightening effect is further enhanced.

3. The liquorice root extract is preferably added, the formation of melanin is inhibited through the liquorice root extract, the whitening and skin brightening effects are achieved, the liquorice root extract contains components with sunscreen efficacy, ultraviolet light and visible light are strongly absorbed, the sunscreen effect is further enhanced, and the skin brightening effect of the skin in the reverse age can be enhanced.

Drawings

Fig. 1 is a process flow chart of a preparation method of a rejuvenation and anti-aging treatment stock solution in the application.

Detailed Description

The present application will be described in further detail with reference to the following drawings and examples.

The information on the source of each component used in the following examples and comparative examples is shown in Table 1.

TABLE 1

Examples 1 to 5

A rejuvenating, anti-aging and repairing stock solution comprises water, a chelating agent A, a skin conditioner A, a solvent B, a humectant B, encapsulated azelaic acid, ellagic acid, an antioxidant C, a solvent D and an antiseptic synergist D.

The chelating agent A is one or more of disodium EDTA and trisodium ethylenediamine disuccinate, and the skin conditioner A is one or more of nicotinamide, acetyl chitosamine, glycerol, erythritol and poly gamma-sodium glutamate;

the solvent B is one or more of butanediol and isopropanol, and the humectant B is one or more of sodium hyaluronate, acetylated sodium hyaluronate and hydrolyzed sodium hyaluronate;

the antioxidant C is one or more of carnosine and hydrogenated lecithin;

the solvent D is one or more of propylene glycol and hexylene glycol, and the preservative synergist D is one or more of caprylyl hydroximic acid and phenoxyethanol.

In examples 1 to 5, the amounts (in kg) of the respective raw materials are shown in Table 2.

TABLE 2

Referring to fig. 1, the preparation method of the rejuvenation and anti-aging repair stock solution of examples 1 to 5 includes the following steps:

step 1), selectively weighing water, EDTA disodium, trisodium ethylenediamine disuccinate, nicotinamide, acetyl chitosamine, glycerol, erythritol and poly gamma-sodium glutamate according to a formula, adding into an emulsifying pot, heating and stirring until the temperature reaches 85 ℃, and keeping the temperature for 30 min;

step 2), selecting and weighing butanediol, isopropanol, sodium hyaluronate, acetylated sodium hyaluronate and hydrolyzed sodium hyaluronate according to a formula, adding the materials into an emulsifying pot, rotating at 1000r/min, homogenizing for 3min, adjusting to a stirring state, keeping the stirring speed at 30r/min, keeping the temperature at 85 ℃ for 30min, and cooling;

step 3), cooling to 50 ℃, selectively weighing propylene glycol, hexanediol, caprylyl hydroximic acid and phenoxyethanol according to a formula, adding the mixture into an emulsifying pot, keeping stirring for 20r/min, and cooling;

and 4), cooling to 35 ℃, selectively weighing carnosine, hydrogenated lecithin, coated azelaic acid and ellagic acid according to the formula, adding into an emulsifying pot, filtering and discharging.

Examples 6 to 8

A rejuvenating and anti-aging repair stock solution is different from the stock solution in example 5 only in that:

adenosine triphosphate is also included.

In examples 6 to 8, the amount (in kg) of adenosine triphosphate to be added is shown in Table 3.

TABLE 3

	Example 6	Example 7	Example 8
				Adenosine triphosphate	1	2	1.45

Adenosine triphosphate in step 4), is added to the emulsification vessel together with carnosine, encapsulated azelaic acid, ellagic acid.

Examples 9 to 11

also included are dimethyl isosorbide anhydrides.

In examples 9 to 11, the amount (in kg) of dimethyl isosorbide to be added is shown in Table 4.

TABLE 4

The dimethyl isosorbide anhydride is added into the emulsifying pot in the step 4) together with carnosine, encapsulated azelaic acid and ellagic acid.

Examples 12 to 14

also comprises Glycyrrhrizae radix extract.

In examples 12 to 14, the amount (in kg) of the licorice root extract added is shown in Table 5.

TABLE 5

	Example 12	Example 13	Example 14
				Licorice root extract	0.1	0.5	0.3

The licorice root extract is added to the emulsifying pot in step 4) together with carnosine, encapsulated azelaic acid and ellagic acid.

Examples 15 to 17

hydroxy pinacolone retinoic acid ester is also included.

In examples 15 to 17, the amount (in kg) of the licorice root extract added is shown in Table 6.

TABLE 6

Hydroxy pinacolone retinoic acid ester in step 4), is added to the emulsification vessel together with carnosine, encapsulated azelaic acid, ellagic acid.

Examples 18 to 20

also comprises adenosine triphosphate, poly-isosorbide dimethyl ether, licorice root extract and hydroxy pinacolone retinoic acid ester.

In examples 18 to 20, the amounts (in kg) of adenosine triphosphate, isosorbide dimethyl ether, licorice root extract and hydroxyppinacolone retinoic acid ester to be added are shown in Table 7.

TABLE 7

Adenosine triphosphate, isosorbide dimethyl ether, licorice root extract and hydroxy pinacolone retinoic acid ester are added into an emulsifying pot together with carnosine, encapsulated azelaic acid and ellagic acid in the step 4).

Comparative example 1

when preparing the rejuvenation anti-aging repair stock solution, the same amount of azelaic acid is used for replacing the coating azelaic acid.

Comparative example 2

when preparing the rejuvenation anti-aging repairing stock solution, equivalent water is used for replacing ellagic acid.

Experiment 1

And (3) testing the whitening effect:

the samples of the rejuvenation anti-aging repair stock solution prepared in the examples and the comparative examples are subjected to tyrosinase inhibition rate test according to the standard of T/SHRH 015-2018, cosmetic-tyrosinase activity inhibition experiment method.

Experiment 2

And (3) testing the antioxidant effect:

experiment design:

1. preparation of DPPH test solution: taking 20mg of DPPH solid, using absolute ethyl alcohol to fix the volume to 250ml, carrying out ultrasonic treatment for 5min, and fully shaking to ensure that all parts are uniform.

2. Preparation of test sample liquid: 20mg of the rejuvenation and anti-aging repairing stock solution prepared in each example and comparative example is taken, diluted by absolute ethyl alcohol and metered to 250 ml.

3. Pre-testing: placing 2ml of test sample solution and 2ml of DPPH test solution in a test tube, placing in a thermostat at 37 deg.C for 1h, using anhydrous ethanol as blank control, and measuring absorbance A of each test sample solution at 517nm₁And calculating the free radical scavenging rate, measuring three groups of parallel samples by each test sample solution and each DPPH test solution, and averaging.

4. Data processing:

radical scavenging rate (%) - (1- (a)₀-A₁)/A₀]×100％

A₀The value: 2ml absolute ethyl alcohol and 2ml DPPH test solution absorbance;

A₁the value: 2ml of test sample solution is added with the absorbance of 2ml of DPPH test solution;

A₃the value: absorbance of 2ml of test sample plus 2ml of absolute ethanol.

Experiment 3

And (3) testing the sun protection effect:

the absorbance of the samples prepared from the rejuvenation and anti-aging repairing stock solutions prepared in the examples and the comparative examples was measured according to QB/T2410-1998 ultraviolet absorbance method for evaluating sunscreen effect in UVB region of sunscreen cosmetics. .

The data for the tests 1-3 are detailed in Table 8.

TABLE 8

According to the data comparison of table 8, the data of comparative example 1 and example 5 show that, the azelaic acid is coated in the rejuvenation and anti-aging original liquid, compared with adding azelaic acid, the tyrosinase inhibition rate and the radical scavenging rate are obviously increased, the skin can be obviously promoted to absorb effective components, the effect of skin lightening through inverse age is better, the absorbance is obviously increased, and certain sunscreen effect is achieved by the interaction of the coated azelaic acid and ellagic acid.

According to the comparison of the data in table 8 and comparative example 2 and example 5, the azelaic acid coated alone is added into the rejuvenation and anti-aging repairing stock solution, the tyrosinase inhibition rate and the radical scavenging rate have no obvious change, the effect of skin lightening with inverse age is not obviously affected, the absorbance is obviously reduced, and the azelaic acid coated alone has no sunscreen effect when being added into the rejuvenation and anti-aging repairing stock solution.

As shown in table 8, when the data of examples 12 to 14 are compared with those of example 5, the anti-aging and rejuvenating liquid for children is further added with licorice root extract, so that the tyrosinase inhibition rate, the radical scavenging rate and the absorbance are relatively increased, and the skin-whitening effect and the sunscreen effect of the skin are improved to a certain extent.

The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.

Claims

1. The rejuvenation anti-aging repairing stock solution is characterized in that: the paint is prepared from a component A, a component B, a component C and a component D, wherein the component A comprises the following components in percentage by mass:

the balance of water;

0.01 to 0.1 percent of chelating agent A;

8% -12% of a skin conditioner A;

the component B comprises the following components in percentage by mass:

2% -5% of a solvent B;

0.1 to 0.5 percent of humectant B;

the component C comprises the following components in percentage by mass:

0.5 to 1.5 percent of antioxidant C;

wrapping azelaic acid 2-5%;

2% -5% of ellagic acid;

the component D comprises the following components in percentage by mass:

0.5 to 2 percent of solvent D;

0.01 to 0.1 percent of antiseptic synergist D.

2. The rejuvenation and anti-aging repairing stock solution as defined in claim 1, wherein: the component C also comprises the following components in percentage by mass:

1% -2% of adenosine triphosphate.

3. The rejuvenation and anti-aging repairing stock solution as defined in claim 1, wherein: the component C also comprises the following components in percentage by mass:

0.5 to 2 percent of isosorbide dimethyl ether.

4. The rejuvenation and anti-aging repairing stock solution as defined in claim 1, wherein: the component C also comprises the following components in percentage by mass:

licorice root extract 0.1-0.5%.

5. The rejuvenation and anti-aging repairing stock solution as defined in claim 1, wherein: the component C also comprises the following components in percentage by mass:

0.5 to 1.5 percent of hydroxy pinacolone retinoic acid ester.

6. The rejuvenating and anti-aging original liquid as claimed in claim 1, wherein the skin conditioner A comprises at least the following components in percentage by mass:

4% -6% of nicotinamide;

1 to 3 percent of acetyl chitosamine.

7. The preparation method of the rejuvenation and anti-aging repairing stock solution as defined in claim 1, wherein: the method comprises the following steps:

and 4) after cooling, weighing the antioxidant C, the coated azelaic acid and the ellagic acid according to the formula, adding into a container, uniformly mixing, filtering and discharging.

8. The preparation method of the rejuvenation and anti-aging repairing stock solution as defined in claim 7, wherein: the method comprises the following steps: