CN112618395B - Mite-killing composition and preparation method and application thereof - Google Patents
Mite-killing composition and preparation method and application thereof Download PDFInfo
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- CN112618395B CN112618395B CN202011639501.6A CN202011639501A CN112618395B CN 112618395 B CN112618395 B CN 112618395B CN 202011639501 A CN202011639501 A CN 202011639501A CN 112618395 B CN112618395 B CN 112618395B
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- honokiol
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- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 26
- 239000011593 sulfur Substances 0.000 claims abstract description 26
- VVOAZFWZEDHOOU-UHFFFAOYSA-N honokiol Natural products OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 claims abstract description 24
- BYTORXDZJWWIKR-UHFFFAOYSA-N Hinokiol Natural products CC(C)c1cc2CCC3C(C)(CO)C(O)CCC3(C)c2cc1O BYTORXDZJWWIKR-UHFFFAOYSA-N 0.000 claims abstract description 14
- FVYXIJYOAGAUQK-UHFFFAOYSA-N honokiol Chemical compound C1=C(CC=C)C(O)=CC=C1C1=CC(CC=C)=CC=C1O FVYXIJYOAGAUQK-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 9
- 244000144730 Amygdalus persica Species 0.000 claims description 8
- CKZZREIPBTYJEQ-UHFFFAOYSA-N Totarol Natural products C1CC2C(C)(C)CCCC2(C)C2=C1C(C(C)C)=C(C)C=C2 CKZZREIPBTYJEQ-UHFFFAOYSA-N 0.000 claims description 8
- ZRVDANDJSTYELM-FXAWDEMLSA-N totarol Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C)C1=C2C(C(C)C)=C(O)C=C1 ZRVDANDJSTYELM-FXAWDEMLSA-N 0.000 claims description 8
- 229940074347 totarol Drugs 0.000 claims description 8
- ZRVDANDJSTYELM-UHFFFAOYSA-N trans-totarol Natural products C1CC2C(C)(C)CCCC2(C)C2=C1C(C(C)C)=C(O)C=C2 ZRVDANDJSTYELM-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 3
- 239000005864 Sulphur Substances 0.000 claims 1
- 241000238876 Acari Species 0.000 abstract description 9
- 230000002147 killing effect Effects 0.000 abstract description 9
- 230000002195 synergetic effect Effects 0.000 abstract description 9
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- 231100000344 non-irritating Toxicity 0.000 abstract description 4
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- 239000003755 preservative agent Substances 0.000 abstract description 4
- 240000006413 Prunus persica var. persica Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 16
- 230000000052 comparative effect Effects 0.000 description 13
- 210000003491 skin Anatomy 0.000 description 12
- 238000012360 testing method Methods 0.000 description 8
- 239000000284 extract Substances 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241001128004 Demodex Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 239000004519 grease Substances 0.000 description 3
- 210000003780 hair follicle Anatomy 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
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- 229920000832 Cutin Polymers 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
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- 210000001732 sebaceous gland Anatomy 0.000 description 2
- PNXZXMPQNMBESC-UHFFFAOYSA-N 4-phenyl-2,6-bis(prop-2-enyl)benzene-1,3-diol Chemical compound C(C=C)C1=C(C(=CC(=C1O)CC=C)C1=CC=CC=C1)O PNXZXMPQNMBESC-UHFFFAOYSA-N 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
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- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
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- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 241000186427 Cutibacterium acnes Species 0.000 description 1
- 208000006313 Delayed Hypersensitivity Diseases 0.000 description 1
- 241000193880 Demodex folliculorum Species 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 244000208060 Lawsonia inermis Species 0.000 description 1
- 241000218378 Magnolia Species 0.000 description 1
- 241001673966 Magnolia officinalis Species 0.000 description 1
- 241000218377 Magnoliaceae Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 244000203593 Piper nigrum Species 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 244000086363 Pterocarpus indicus Species 0.000 description 1
- 235000009984 Pterocarpus indicus Nutrition 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 241000293861 Scrophularia nodosa Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 241001671204 Stemona Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- -1 aromatic diterpene Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
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- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 229930004069 diterpene Natural products 0.000 description 1
- GRWZHXKQBITJKP-UHFFFAOYSA-L dithionite(2-) Chemical compound [O-]S(=O)S([O-])=O GRWZHXKQBITJKP-UHFFFAOYSA-L 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000033687 granuloma formation Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 description 1
- 235000019136 lipoic acid Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000018528 secretion by tissue Effects 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides an acarid-removing composition, a preparation method and application thereof. The mite-killing composition comprises the following components in parts by weight: 0.01 to 0.3 part of honokiol; 0.01 to 0.3 part of peach toposide; 0.1 to 2 portions of nano sulfur. The mite-killing composition provided by the invention is compounded by utilizing various plant extracts, contains natural plant components, is mild and non-irritating, has the synergistic effect of various active components, can play a good role in sterilizing and killing mites under the condition of low usage amount, and can also reduce the usage amount of preservatives in cosmetics and reduce the irritation to skin.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an anti-mite composition as well as a preparation method and application thereof.
Background
Human demodex is a conditionally pathogenic small parasitic mite, two common types of demodex folliculorum and demodex sebaceous gland are mainly parasitic in hair follicles and sebaceous glands, and weak resistance to high temperature, dryness and alkaline environment can cause various common skin diseases under certain conditions, and possible mechanisms for causing skin damage include mechanical blockage of hair follicles, hair follicle expansion and excessive keratinization; resistance is reduced, and bacterial and fungal infections are easily caused; the chitin exoskeleton of mites contributes to granuloma formation; demodex faeces may activate the immune system and cause delayed hypersensitivity etc. which seriously affect the health and beauty of people.
The most of the products which are used for mildly removing mites by using plant preparations in the market at present are to add plant extracts with the effects of sterilizing and removing mites, such as patent CN111789786A, and the mite-removing plant composition is disclosed, wherein the mite-removing effect is realized by the synergistic effect among rosewood seed extract, pepper fruit extract, radix sophorae flavescentis extract, stemona root extract and cortex phellodendri extract, the active ingredients which are mainly used for the preparations are usually not high, a large addition amount is often required to really realize the mite-removing effect, and the extracts related to the herbal medicines also contain more other complex ingredients and extraction solvents, and a large amount of the extracts are added into the products to have other potential risks, so that the stability, the appearance, the smell and the like of the system can be influenced. In addition, certain amounts of chemical mite-removing agents are added or compounded in the formula by a merchant to achieve a better mite-removing effect, but the chemical mite-removing agents often have certain irritation to skin, and certain chemical mite-removing agents also have certain toxicity.
In general, there is currently a lack of technical applications associated with natural actives that achieve high levels of mite removal and are mild and non-irritating.
Disclosure of Invention
The invention aims to overcome the defects of poor mite removal effect or certain skin irritation in the prior art and provide a mite removal composition. The mite-killing composition provided by the invention is compounded by utilizing various plant extracts, contains natural plant components, is mild and non-irritating, has the synergistic effect of various active components, can play a good role in sterilizing and killing mites under the condition of low usage amount, and can also reduce the usage amount of preservatives in cosmetics and reduce the irritation to skin.
It is another object of the present invention to provide a method for preparing the mite-killing composition.
It is a further object of the present invention to provide the use of the mite-killing composition for preparing cosmetics.
In order to achieve the aim of the invention, the invention adopts the following technical scheme:
the mite-killing composition comprises the following components in parts by weight:
0.01 to 0.3 part of magnolol;
0.01 to 0.3 part of peach toposide;
0.1 to 2 portions of nano sulfur.
Honokiol, commonly found in magnolia bark of magnolia of magnoliaceae, is also known as 3, 5-di-2-propenyl-1, 1-biphenyl-2, 4-diol, is a tan to white fine powder, is dissolved in ethanol, propylene glycol, hexanediol and the like or alkaline medium, has broad-spectrum antibacterial effect, has stronger antibacterial property on gram-positive bacteria and gram-negative bacteria, has stable antibacterial property, is not easy to be damaged by heat, acid and alkali, and has the strongest inhibition effect on staphylococcus aureus; the inventor finds that the anti-mite agent also has better anti-mite and synergistic anti-mite effects.
The peach topol is commonly found in the arhat pine, is rich in aromatic diterpene, can inhibit peroxidation of grease, is a high-efficiency antibacterial agent, has better antibacterial effect on gram positive bacteria including streptococcus, bacillus subtilis, staphylococcus aureus, propionibacterium acnes and the like, and has no irritation and anaphylactic reaction to human skin. The inventor finds that the anti-mite agent also has a certain anti-mite and synergistic anti-mite effect.
The nanometer sulfur has the effects of killing scabies, bacteria and fungi, removing grease, softening epidermis and dissolving cutin, and the action mechanism is the result of generating hydrogen sulfide, dithionite and the like after the sulfur contacts skin and tissue secretion.
The inventor of the invention finds that by using magnolol, totarol and nano sulfur to carry out specific compounding, the composition obtained by compounding the magnolol, the totarol and the nano sulfur has better synergistic effect in the aspect of mite removal, contains natural plant components, is mild and does not irritate, and a plurality of active components have synergistic effect, so that the cosmetic can play a good role in sterilizing and removing mites under the condition of lower using amount, and can also reduce the using amount of preservatives in the cosmetic and reduce the irritation to skin. The nano sulfur can soften skin superfluous cutin, dredge pores, and the peach phenol can regulate grease secretion, and has synergistic effect with honokiol to achieve the effects of inhibiting bacteria and killing mites.
Preferably, the mite-killing composition comprises the following components in parts by weight:
0.015-0.15 part of honokiol;
0.015-0.15 part of peach toposide;
0.3 to 1.0 part of nano sulfur.
Further preferably, the mite-killing composition comprises the following components in parts by weight:
0.03 parts of honokiol;
0.08 part of peach toposide;
0.5 part of nano sulfur.
Preferably, the honokiol and the totarol are commercial raw materials, and the purity is more than 98%.
Preferably, the nano sulfur is nano biological sulfur.
Preferably, the nano biological sulfur is coated in a nano carrier.
Preferably, the nano-carrier is one or a combination of a plurality of lipoic acid, phospholipid and caprylic/capric triglyceride.
The nanometer sulfur can be suspended in colloid solution, has better diffusion and higher skin activity, and has no irritation to skin. The effect of the direct interaction of nano sulfur and skin depends on the particle size, and the larger the effective area of the interaction of sulfur and skin is, the larger the effect is.
Preferably, the particle size of the nano sulfur is 1-100 μm.
The preparation method of the mite-killing composition comprises the following steps: mixing the honokiol, the totarol, the nano sulfur and the water to obtain the mite-removing composition.
Preferably, the temperature of the mixing is 40-45 ℃.
Preferably, the mixing time is 30 to 40 minutes.
The mite-killing composition (or the dilution thereof (the mass fraction of the mite-killing composition is 0.2-3.0 wt%) can be directly sprayed on the skin.
The mite-killing composition can also be added into mite-killing products (such as cosmetics) as an effective component.
The use of the above-described mite-killing composition in the preparation of mite-killing products is also within the scope of the present invention.
Preferably, the mite-killing composition is added in an amount of 0.2-3.0 wt% in the mite-killing product.
Compared with the prior art, the invention has the following beneficial effects:
the mite-killing composition provided by the invention is compounded by utilizing various plant extracts, contains natural plant components, is mild and non-irritating, can play a good role in sterilizing and killing mites under the condition of low usage amount by the synergistic effect of the magnolol, the totarol and the nano sulfur, and can also reduce the usage amount of preservative in cosmetics and reduce the irritation to skin.
Detailed Description
The invention is further illustrated below with reference to examples. These examples are only for illustrating the present invention and are not intended to limit the scope of the present invention. The experimental procedures in the examples below, without specific details, are generally performed under conditions conventional in the art or recommended by the manufacturer; the raw materials, reagents and the like used, unless otherwise specified, are those commercially available from conventional markets and the like. Any insubstantial changes and substitutions made by those skilled in the art in light of the above teachings are intended to be within the scope of the invention as claimed.
The raw materials selected in each example and comparative example of the present invention are described below:
honokiol: HPH98, 98% pure, purchased from henna and broad biotechnology limited;
peach leaf phenol: wkq-05832 with purity not less than 98% and available from Sichuan Vickers biotechnology Co., ltd;
nano sulfur: nanoActive Sulfur from the Puri Biomedicine.
Examples 1 to 5 and comparative examples 1 to 3
The present example provides a series of the above mite-killing compositions, which are obtained by mixing magnolol, totarol, and nano sulfur according to the formulation in table 1.
The above mite-killing composition was diluted into a dilution liquid having a mass fraction of 2.0wt% to obtain the mite-killing composition dilutions of examples 1 to 5 and comparative examples 1 to 3.
Table 1 formulations (parts by weight, total weight 100 parts) of the mite-killing compositions of each of the examples and comparative examples
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| Honokiol of honokiol | 0.01 | 0.015 | 0.03 | 0.15 | 0.3 | / | 0.03 | 0.03 |
| Peach-leaf alcohol | 0.01 | 0.015 | 0.08 | 0.15 | 0.3 | 0.08 | / | 0.08 |
| Nanometer sulfur | 0.1 | 0.3 | 0.5 | 1.0 | 2.0 | 0.5 | 0.5 | / |
。
Comparative example 4
The comparative example is a commercial kernel and mugwort mite-repellent spray.
Performance testing
The mite-killing compositions provided in each of the examples and comparative examples were tested as follows.
1. Mite removal effect: according to NY/T1151.2-2006, method for testing indoor efficacy of pesticides for pesticide registration sanitary purposes, evaluation part 2: mite killing effect test was carried out in mite killing and dispelling agent.
Wherein, the test group was sprayed with the dilutions of the mite-killing composition prepared in each of the examples and the comparative examples, and the blank control group was not subjected to any treatment.
Mite killing rate = number of dead test insects/number of test insects x 100%
The test results are shown in table 2:
table 2 results of mite-killing test for each of the dilutions of the mite-killing composition of each of the examples and comparative examples
As can be seen from Table 2, the mite-killing effect of the mite-killing composition provided by each embodiment of the invention is better, and the mite-killing rate of more than 95% can be achieved by compounding the components with lower dosage. From example 3 and comparative examples 1-3, it is evident that the composition has significantly reduced killing effect on mites in the absence of either honokiol, totarol or nano sulfur. Compared with the commercial mite-killing products, the effect is remarkable.
Those of ordinary skill in the art will recognize that the embodiments herein are intended to assist the reader in understanding the principles of the invention and should be understood that the scope of the invention is not limited to such specific statements and embodiments. Those of ordinary skill in the art can make various other specific modifications and combinations from the teachings of the present disclosure without departing from the spirit thereof, and such modifications and combinations remain within the scope of the present disclosure.
Claims (7)
1. The application of the mite-killing composition in preparing mite-killing products is characterized in that the mite-killing composition comprises the following components in parts by weight:
0.015-0.15 part of honokiol;
0.015-0.15 part of peach toposide;
0.3 to 1.0 part of nano sulfur;
the addition amount of the mite-killing composition in the mite-killing product is 0.2-3 wt%.
2. The use according to claim 1, characterized in that the mite-killing composition consists of the following components in parts by weight:
0.03 parts of honokiol;
0.08 part of peach toposide;
0.5 part of nano sulfur.
3. The use according to claim 1, wherein the nanosulfur in the mite-killing composition is nanosulfur.
4. The use according to claim 3, wherein the particle size of the nano-biological sulphur is 1-100 μm.
5. A process for the preparation of a mite-killing composition for use according to any one of claims 1 to 4, comprising the steps of: mixing the honokiol, the totarol and the nano sulfur to obtain the mite-removing composition.
6. The process according to claim 5, wherein the temperature of the mixing is 40 to 45 ℃.
7. The method according to claim 5, wherein the mixing time is 30 to 40 minutes.
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