CN112604191A - Multi-focus ultrasonic wave generation device and method - Google Patents
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Abstract
本发明提供了一种多焦点超声波的生成装置及生成方法，所述生成装置包括超声激励模块、控制模块、监测模块及反馈模块，所述超声激励模块包括多个超声换能器，所述控制模块用于根据多个目标靶点的超声参数分别控制多个超声换能器发射超声脉冲信号至多个目标靶点，所述监测模块用于检测超声换能器发射的超声脉冲信号是否聚焦至目标靶点，所述反馈模块用于在超声换能器发射的超声脉冲信号未聚焦至目标靶点时发送反馈信号至所述控制模块，所述控制模块根据所述反馈信号调节超声换能器的位置，以使超声换能器发射的超声脉冲信号聚焦至目标靶点。本发明提供的多焦点超声波的生成装置能够根据需要实时、动态地对多个目标靶点进行精准刺激。
The present invention provides a multi-focus ultrasonic generation device and a generation method, the generation device includes an ultrasonic excitation module, a control module, a monitoring module and a feedback module, the ultrasonic excitation module includes a plurality of ultrasonic transducers, the control module The module is used to respectively control the multiple ultrasonic transducers to transmit ultrasonic pulse signals to the multiple target points according to the ultrasonic parameters of the multiple targets, and the monitoring module is used to detect whether the ultrasonic pulse signals emitted by the ultrasonic transducers are focused to the target The target point, the feedback module is used to send a feedback signal to the control module when the ultrasonic pulse signal emitted by the ultrasonic transducer is not focused on the target target point, and the control module adjusts the ultrasonic transducer according to the feedback signal. position, so that the ultrasonic pulse signal emitted by the ultrasonic transducer is focused to the target point. The multifocal ultrasonic wave generating device provided by the present invention can accurately stimulate multiple target points in real time and dynamically as required.
Description
Technical Field
The invention relates to the technical field of ultrasonic application, in particular to a generating device and a generating method of multi-focus ultrasonic waves.
Background
With environmental changes, aging of the population, and the acceleration and increasing competition in the rhythm of social life, neuropsychiatric diseases, particularly parkinson's disease, epilepsy, and depression, have become major medical problems and a heavy social burden worldwide. Similarly, the population base of China is huge, aging is improved year by year, and the prevention and treatment of neuropsychiatric system diseases become a heavy economic burden and social problem in China's society. At present, a safe and effective clinical treatment means is provided for patients with neuropsychiatric diseases by a physical Brain Stimulation nerve regulation technology (Deep Brain Stimulation, Transcranial Magnetic Stimulation and the like). Except for classical electric and magnetic regulation and control means, the ultrasound is used as mechanical wave and also has energy, can deliver the energy to deep nerve nuclei in a non-invasive manner, and the stimulation and regulation and control effect of the ultrasound on neuron cells opens a new visual field for a non-invasive brain stimulation technology.
Neuropsychiatric diseases often occur not only in neuronal dysfunction within a single nuclear cluster but also in direct association with multinuclear cluster abnormalities in the brain functional network. For example, dysfunction of the multifunctional loop plays a critical role in the pathogenesis of epilepsy, which includes primarily the hippocampal amygdala loop, the cortico-subcortical loop, the basal ganglia loop, and the like. The existing physical brain stimulation nerve regulation and control technology has the following defects: the application of the deep brain stimulation technology requires implanting an electrode into deep brain tissue through craniotomy, the stimulation target point cannot be replaced, and the whole power supply equipment needs to be implanted into a body through surgery; the transcranial magnetic stimulation technology has the bottlenecks of insufficient stimulation depth, incapability of focusing, low stimulation resolution, difficulty in determining a stimulation area and the like; the light sensitive gene regulation technology can not be used for treating clinical brain diseases because virus protein needs to be transfected; compared with the former physical brain stimulation nerve regulation and control technologies, the novel ultrasonic nerve regulation and control technology has the unique advantages of no wound, deep brain stimulation, dynamic focus adjustment and the like, but the preclinical research of the ultrasonic nerve regulation and control technology and the clinical research of partial people mainly apply single focus stimulation, and the intervention effect on neuropsychiatric system diseases is poor.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a generating device and a generating method of multi-focus ultrasonic waves, which can accurately stimulate a plurality of target points dynamically in real time according to needs.
The specific technical scheme provided by the invention is as follows: the generating device comprises an ultrasonic excitation module, a control module, a monitoring module and a feedback module, wherein the ultrasonic excitation module comprises a plurality of ultrasonic transducers, the control module is used for respectively controlling the plurality of ultrasonic transducers to emit ultrasonic pulse signals to the plurality of target points according to ultrasonic parameters of the plurality of target points, the monitoring module is used for detecting whether the ultrasonic pulse signals emitted by the ultrasonic transducers are focused on the target points, the feedback module is used for sending feedback signals to the control module when the ultrasonic pulse signals emitted by the ultrasonic transducers are not focused on the target points, and the control module adjusts the positions of the ultrasonic transducers according to the feedback signals so as to focus the ultrasonic pulse signals emitted by the ultrasonic transducers on the target points.
Further, the control module comprises a modulation unit and a parameter determination unit, the parameter determination unit is used for determining ultrasonic parameters of a plurality of target points, and the modulation unit is used for selecting the ultrasonic transducer to be turned on according to the ultrasonic parameters of the target points.
Further, the control module further comprises a delay unit, and the delay unit is used for generating a time interval between the emission of the ultrasonic pulse signal by each array element in the ultrasonic transducer.
Further, the time interval is generated by the time delay unit according to the position information and the acoustic parameters of the target point and the position information of the array element of the ultrasonic transducer.
Further, the acoustic parameters include density, sound velocity, and attenuation coefficient.
Further, the control module further comprises a start control unit, and the start control unit is used for controlling the array elements in the ultrasonic transducer to transmit ultrasonic pulse signals according to the time intervals and the ultrasonic parameters.
Further, each ultrasonic transducer comprises a first array element group and a second array element group, the first array element group and the second array element group respectively comprise at least one array element, and the second array element group is centered on the first array element group, surrounds the first array element group and is radially arranged towards the periphery.
The invention also provides a method for generating the multifocal ultrasonic wave, which comprises the following steps:
acquiring ultrasonic parameters of a plurality of target points;
respectively carrying out ultrasonic pulse signal stimulation on the multiple target points according to the ultrasonic parameters of the multiple target points;
and judging whether the ultrasonic pulse signal is focused on the target spot, and if the ultrasonic pulse signal is not focused on the target spot, adjusting the emergent direction of the ultrasonic pulse signal to focus the ultrasonic pulse signal on the target spot.
Further, the performing ultrasonic pulse signal stimulation on the multiple target points according to the ultrasonic parameters of the multiple target points respectively includes:
acquiring time intervals between ultrasonic pulse signals;
and performing ultrasonic pulse signal stimulation on a plurality of target points according to the time interval and the ultrasonic parameters.
Further, the time interval between the acquisition of the ultrasound pulse signals includes:
acquiring position information and acoustic parameters of a target point and position information of an array element of an ultrasonic transducer;
and calculating the time interval between the ultrasonic pulse signals according to the position information and the acoustic parameters of the target point and the position information of the array element of the ultrasonic transducer.
The device for generating the multi-focus ultrasonic waves controls the ultrasonic transducers to emit ultrasonic pulse signals to the target points through the control module, detects whether the ultrasonic pulse signals emitted by the ultrasonic transducers are focused on the target points through the monitoring module, sends feedback signals to the control module through the feedback module when the ultrasonic pulse signals emitted by the ultrasonic transducers are not focused on the target points, and adjusts the positions of the ultrasonic transducers according to the feedback signals so that the ultrasonic pulse signals are focused on the target points, thereby accurately stimulating the target points dynamically in real time.
Drawings
The technical solution and other advantages of the present invention will become apparent from the following detailed description of specific embodiments of the present invention, which is to be read in connection with the accompanying drawings.
Fig. 1 is a schematic structural diagram of a multifocal ultrasonic wave generation device in an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of a wearing portion according to an embodiment of the present invention;
fig. 3a to 3b are schematic diagrams illustrating an arrangement of a plurality of array elements in an ultrasonic transducer according to an embodiment of the present invention;
FIG. 4 is a schematic illustration of an ultrasonic pulse signal in an embodiment of the present invention;
fig. 5 is a flowchart illustrating a method for generating a multifocal ultrasonic wave according to an embodiment of the present invention.
Detailed Description
Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the specific embodiments set forth herein. Rather, these embodiments are provided to explain the principles of the invention and its practical application to thereby enable others skilled in the art to understand the invention for various embodiments and with various modifications as are suited to the particular use contemplated. In the drawings, like reference numerals will be used to refer to like elements throughout.
Medical ultrasonic waves interact with human tissues, mainly by using the fluctuation effect of the interaction of sound waves and substances. Besides basic physical properties, ultrasound also has three basic acoustic effects, namely mechanical effects, thermal effects and cavitation effects. Objects or biological tissues in the acoustic field are subjected to forces due to absorption, scattering, reflection of acoustic waves, which convert the energy of the acoustic waves into physical momentum, defined in acoustics as ultrasonic radiation force. In recent years, the non-invasive stimulation and regulation effect of ultrasound on deep brain nuclei opens a new visual field for a nerve regulation technology, and multi-level and multi-species researches prove the effectiveness of transcranial ultrasound regulation of cranial nerves and application prospects of intervention on different neuropsychiatric diseases.
Research shows that neuropsychiatric diseases are closely related to the abnormal function of deep brain nucleus, and corresponding neuron cells and nerve nucleus can be physically stimulated to relieve or cure symptoms. In addition, the complexity of the pathogenesis of different neuropsychiatric diseases indicates that the treatment strategy should focus on the selection of "multi-target synergistic intervention", and the realization of stimulation to a plurality of different intracranial targets will contribute to the clinical efficacy of the neuromodulation technology.
The application provides a generating device of multifocal ultrasonic wave, including supersound excitation module, a control module, monitoring module and feedback module, supersound excitation module includes a plurality of ultrasonic transducers, control module is used for controlling a plurality of ultrasonic transducers to launch ultrasonic pulse signal to a plurality of target points respectively according to the supersound parameter of a plurality of target points, monitoring module is used for detecting whether the ultrasonic pulse signal that ultrasonic transducer launched focuses on the target point, feedback module is used for sending feedback signal to control module when the ultrasonic pulse signal that ultrasonic transducer launched does not focus on the target point, control module adjusts the position of ultrasonic transducer according to feedback signal, so that the ultrasonic pulse signal that ultrasonic transducer launched focuses on the target point.
The multi-focus ultrasonic wave generating device provided by the application controls a plurality of mutually independent ultrasonic transducers to transmit ultrasonic pulse signals to a plurality of target spots through the control module, so that multi-target spot stimulation is realized; and then, detecting whether the ultrasonic pulse signal emitted by the ultrasonic transducer is focused on a target point through the monitoring module, sending a feedback signal to the control module through the feedback module when the ultrasonic pulse signal is not focused on the target point, and adjusting the position of the ultrasonic transducer by the control module according to the feedback signal so as to focus the ultrasonic pulse signal on the target point, thereby accurately stimulating a plurality of target points in real time and dynamically and realizing multi-target-point cooperative intervention.
The following describes in detail a device and a method for generating multifocal ultrasonic waves according to the present application with reference to the accompanying drawings by using specific embodiments.
Referring to fig. 1, the device for generating a multi-focus ultrasonic wave provided by this embodiment includes an ultrasonic excitation module 1, a control module 2, a monitoring module 3, and a feedback module 4.
The ultrasonic excitation module 1 comprises a plurality of ultrasonic transducers 11, the control module 2 is used for respectively controlling the plurality of ultrasonic transducers 11 to emit ultrasonic pulse signals to the plurality of target points according to ultrasonic parameters of the plurality of target points, the monitoring module 3 is used for detecting whether the ultrasonic pulse signals emitted by the ultrasonic transducers 11 are focused on the target points, the feedback module 4 is used for sending feedback signals to the control module 2 when the ultrasonic pulse signals emitted by the ultrasonic transducers 11 are not focused on the target points, and the control module 2 adjusts the positions of the ultrasonic transducers 11 according to the feedback signals so that the ultrasonic pulse signals emitted by the ultrasonic transducers are focused on the target points.
Specifically, the plurality of ultrasonic transducers 11 in this embodiment work independently of each other, and the plurality of ultrasonic transducers 11 stimulate the plurality of target points respectively. Each ultrasonic transducer 11 includes a plurality of array elements 110 and a carrier 111 for carrying the plurality of array elements 110, and the plurality of array elements 110 operate independently of each other. Each array element 110 is an ultrasonic probe, and the target point is stimulated by the ultrasonic pulse signal emitted by each array element 110. In this embodiment each array element 110 has a fundamental frequency of 1MHz and a focal spot size of 5 mm.
Referring to fig. 2, the ultrasonic excitation module 1 in the present embodiment further includes a wearing portion 12, and the wearing portion 12 is adapted to be worn on the head of a user and has a shape conforming to the shape of the head of a person. The plurality of ultrasonic transducers 11 are uniformly distributed on the head-contacting surface of the wearing portion 12.
The arrangement of the array elements 110 in each ultrasonic transducer 11 may be the same or different. Preferably, the plurality of array elements 110 in each ultrasonic transducer 11 are arranged differently.
Referring to fig. 3a to 3b, the plurality of array elements 110 may be arranged in a matrix array, and the spacing between two adjacent array elements 110 is equal, as shown in fig. 3 a. The array elements 110 of the ultrasonic transducer are divided into a first array element 200 and a second array element 210, each of the first array element 200 and the second array element 210 includes at least one array element 110, preferably, the second array element 210 is centered on the first array element 200 and arranged radially around the first array element 200, as shown in fig. 3b, fig. 3b exemplarily shows that each of the first array element 200 and the second array element 210 includes two array elements 110, of course, in other embodiments of the present embodiment, the first array element 200 and the second array element 210 may include one array element 110, three array elements 110 or more array elements 110, and the number of the array elements 110 in the first array element 200 and the second array element 210 may be equal or unequal. The included angle between two adjacent second array elements 210 is equal, and the array elements 110 in the first array element 200 and the second array element 210 are arranged in a straight line. The sound field modulation may be better performed by centering the second array element 210 on the first array element 200 and radiating around the first array element 200 to obtain the desired sound field.
The control module 2 comprises a modulation unit 21 and a parameter determination unit 22, the parameter determination unit 22 is used for determining ultrasonic parameters of a plurality of target points, and the modulation unit 21 is used for selecting the ultrasonic transducer 11 to be turned on according to the ultrasonic parameters of the plurality of target points.
Specifically, the parameter determination unit 22 obtains the ultrasound parameters of the target point according to the disease type, the disease severity, the type of the target point and the desired stimulation effect. The ultrasonic parameters in the present embodiment include a fundamental frequency, a pulse amplitude, a pulse repetition frequency, a pulse length, and the like, and fig. 4 exemplarily shows the fundamental frequency, the pulse amplitude, the pulse repetition frequency, the pulse length, and the like of one ultrasonic pulse signal.
The parameter determining unit 22 sends the ultrasound parameters of the target point to the modulating unit 21, and the modulating unit 21 selects the ultrasound transducer 11 corresponding to the target point according to the relative position of the target point and the ultrasound transducer 11, the shape and the depth of the target point, for example, in an embodiment, the distance and the angle between the target point and the ultrasound transducer 11 may be selected, that is, the ultrasound transducer 11 closest to the target point is used as the excitation source of the target point, and when the distances are equal, the angle between the target point and the ultrasound transducer 11 may be selected, and the ultrasound transducer 11 stimulating the target point at the optimal angle is selected as the excitation source of the target point. The depth of the target point is the same as the distance between the target point and the ultrasonic transducer 11, and the detailed description is omitted here. In another embodiment, the shape of the target point may be selected, and the ultrasound transducer 11 in which the array elements 110 are arranged in a manner that best matches the shape of the target point is selected as the excitation source of the target point.
The control module 2 further comprises a delay unit 23, and the delay unit 23 is configured to generate a time interval between the emission of the ultrasonic pulse signal by each array element 110 in the ultrasonic transducer 11. A certain time delay exists between two adjacent ultrasonic pulse signals emitted from each ultrasonic transducer 11, so that different depths of stimulation can be performed on the target point, and accurate stimulation on the target point can be realized.
The delay unit 23 generates a time interval between two adjacent ultrasonic pulse signals according to the position information and the acoustic parameters of the target point and the position information of the array element 110 of the ultrasonic transducer 11, where the acoustic parameters of the target point include density, sound velocity, and attenuation coefficient.
The control module 2 in this embodiment further includes a start control unit 24, and the start control unit 24 is configured to control the array element 110 in each ultrasonic transducer 11 to emit an ultrasonic pulse signal according to the time interval and the ultrasonic parameter. The plurality of array elements 110 in the ultrasonic transducer 11 are respectively connected with the start control unit 24 to independently control each array element 110 in the plurality of ultrasonic transducers 11. The modulation unit 21 is connected to the start control unit 24 through a plurality of mutually independent lines, so that the modulation unit 21 independently controls the plurality of ultrasonic transducers 11 to realize multi-target stimulation.
The monitoring module 3 detects whether the ultrasonic pulse signal emitted by the ultrasonic transducer 11 is focused on a target spot according to the electrophysiological signal or the image data, and the monitoring module 3 in this embodiment may be an imaging monitoring system or an electrophysiological monitoring system, wherein the imaging monitoring system includes imaging systems such as MEG, CT, f-MRI, MRS, and the like, and the electrophysiological monitoring system includes an electroencephalogram, electrocardiograph, myoelectricity, heart rate, and deep multichannel electrophysiological monitoring system.
The feedback module 4 is configured to send feedback information to the controller 2 when the monitoring module 3 detects that the ultrasonic pulse signal emitted by the ultrasonic transducer 11 is not focused on the target point, and fine-tune the position of the ultrasonic transducer 11 through a modulation unit 21 in the controller 2, so that the ultrasonic pulse signal emitted by the ultrasonic transducer 11 is focused on the target point. The feedback signal may be position information that the ultrasonic transducer 11 needs to adjust, and the feedback module 4 in this embodiment is further configured to convert the feedback information into a digital signal and send the digital signal to the controller 2.
In the embodiment, the feedback module 4 is used for feeding back the stimulation condition of the target point, so that the multiple target points are accurately and dynamically stimulated in real time, and multi-target-point cooperative intervention is realized.
Referring to fig. 5, the present embodiment further provides a method for generating a multifocal ultrasonic wave, where the method includes:
s1, obtaining ultrasonic parameters of a plurality of target points;
s2, respectively carrying out ultrasonic pulse signal stimulation on the multiple target points according to the ultrasonic parameters of the multiple target points;
and S3, judging whether the ultrasonic pulse signal is focused on the target spot, and if the ultrasonic pulse signal is not focused on the target spot, adjusting the emergent direction of the ultrasonic pulse signal to focus the ultrasonic pulse signal on the target spot.
The control module 2 is used for obtaining ultrasonic parameters of a plurality of target points and respectively controlling a plurality of ultrasonic transducers 11 which are independent of each other to emit ultrasonic pulse signals to the plurality of target points according to the ultrasonic parameters of the plurality of target points.
Specifically, the ultrasound parameters of the target point are obtained by the parameter determination unit 22 in the control module 2 according to the disease type, the disease severity, the type of the target point and the desired stimulation effect. The ultrasound parameters in this embodiment include fundamental frequency, pulse amplitude, pulse repetition frequency, pulse length, and the like. The ultrasonic transducer 11 to be turned on is selected according to the ultrasonic parameters of a plurality of target points through the modulation unit 21 in the control module 2.
Step S2 specifically includes:
s21, acquiring time intervals among the ultrasonic pulse signals;
and S22, performing ultrasonic pulse signal stimulation on the target points according to the time interval and the ultrasonic parameters.
The time interval between the transmission of the ultrasonic pulse signal by each array element 110 in the ultrasonic transducer 11 is generated by the delay unit 23. A certain time delay exists between two adjacent ultrasonic pulse signals emitted from each ultrasonic transducer 11, so that different depths of stimulation can be performed on the target point, and accurate stimulation on the target point can be realized. The array element 110 in each ultrasonic transducer 11 is controlled by the start control unit 24 in the control unit 2 to emit ultrasonic pulse signals according to the time interval and the ultrasonic parameters.
Step S21 specifically includes:
s211, acquiring position information and acoustic parameters of a target point and position information of an array element of an ultrasonic transducer;
s212, calculating the time interval between the ultrasonic pulse signals according to the position information and the acoustic parameters of the target point and the position information of the array element of the ultrasonic transducer.
The delay unit 23 generates a time interval between two adjacent ultrasonic pulse signals according to the position information and the acoustic parameters of the target point and the position information of the array element 110 of the ultrasonic transducer 11, where the acoustic parameters of the target point include density, sound velocity, and attenuation coefficient.
The monitoring module 3 judges whether the ultrasonic pulse signal emitted by the ultrasonic transducer 11 is focused on a target point according to the electrophysiological signal or the image data, if the monitoring module 3 detects that the ultrasonic pulse signal emitted by the ultrasonic transducer 11 is not focused on the target point, the feedback module 4 sends feedback information to the controller 2, and the position of the ultrasonic transducer 11 is finely adjusted by the modulation unit 21 in the controller 2, so that the ultrasonic pulse signal emitted by the ultrasonic transducer 11 is focused on the target point.
The foregoing is directed to embodiments of the present application and it is noted that numerous modifications and adaptations may be made by those skilled in the art without departing from the principles of the present application and are intended to be within the scope of the present application.
Claims (10)
1. The device for generating the multi-focus ultrasonic waves is characterized by comprising an ultrasonic excitation module, a control module, a monitoring module and a feedback module, wherein the ultrasonic excitation module comprises a plurality of ultrasonic transducers, the control module is used for respectively controlling the ultrasonic transducers to emit ultrasonic pulse signals to a plurality of target points according to ultrasonic parameters of the target points, the monitoring module is used for detecting whether the ultrasonic pulse signals emitted by the ultrasonic transducers are focused on the target points, the feedback module is used for sending feedback signals to the control module when the ultrasonic pulse signals emitted by the ultrasonic transducers are not focused on the target points, and the control module adjusts the positions of the ultrasonic transducers according to the feedback signals so that the ultrasonic pulse signals emitted by the ultrasonic transducers are focused on the target points.
2. The generation apparatus according to claim 1, wherein the control module comprises a modulation unit and a parameter determination unit, the parameter determination unit is configured to determine ultrasonic parameters of a plurality of target points, and the modulation unit is configured to select the ultrasonic transducer to be turned on according to the ultrasonic parameters of the plurality of target points.
3. The generation apparatus according to claim 2, wherein the control module further comprises a delay unit, and the delay unit is configured to generate a time interval between the emission of the ultrasonic pulse signal by each array element in the ultrasonic transducer.
4. The generation apparatus of claim 3, wherein the delay unit generates the time interval according to the position information and acoustic parameters of the target point and the position information of the array element of the ultrasonic transducer.
5. The generation apparatus of claim 4, wherein the acoustic parameters include density, speed of sound, attenuation coefficient.
6. The generation apparatus according to claim 3, wherein the control module further comprises a start control unit, and the start control unit is configured to control an array element in the ultrasound transducer to emit an ultrasound pulse signal according to the time interval and the ultrasound parameters.
7. The generating device according to any one of claims 1 to 6, wherein each ultrasonic transducer comprises a first array element and a second array element, each of the first array element and the second array element comprises at least one array element, and the second array elements are arranged around the first array element as a center and in a radial arrangement facing all around the first array element.
8. A method of generating a multifocal ultrasonic wave, the method comprising:
acquiring ultrasonic parameters of a plurality of target points;
respectively carrying out ultrasonic pulse signal stimulation on the multiple target points according to the ultrasonic parameters of the multiple target points;
and judging whether the ultrasonic pulse signal is focused on the target spot, and if the ultrasonic pulse signal is not focused on the target spot, adjusting the emergent direction of the ultrasonic pulse signal to focus the ultrasonic pulse signal on the target spot.
9. The generation method according to claim 8, wherein the performing ultrasonic pulse signal stimulation on the plurality of target points according to the ultrasonic parameters of the plurality of target points respectively comprises:
acquiring time intervals between ultrasonic pulse signals;
and performing ultrasonic pulse signal stimulation on a plurality of target points according to the time interval and the ultrasonic parameters.
10. The generation method according to claim 9, wherein the time interval between the acquisition of the ultrasound pulse signals comprises:
acquiring position information and acoustic parameters of a target point and position information of an array element of an ultrasonic transducer;
and calculating the time interval between the ultrasonic pulse signals according to the position information and the acoustic parameters of the target point and the position information of the array element of the ultrasonic transducer.
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| PCT/CN2020/136774 WO2022126420A1 (en) | 2020-12-14 | 2020-12-16 | Multi-focus ultrasonic wave generation device and generation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114308156A (en) * | 2021-12-23 | 2022-04-12 | 深圳先进技术研究院 | A kind of ultrasonic pipetting device and method |
| CN119258421A (en) * | 2024-09-29 | 2025-01-07 | 广东工业大学 | Ultrasound-guided transcranial nerve regulation system and method |
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| CN116680571A (en) * | 2023-06-29 | 2023-09-01 | 苏州景昱医疗器械有限公司 | Parameter configuration device, medical system, storage medium, and program product |
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| WO2022126420A1 (en) | 2022-06-23 |
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