CN112472894B - System and method for leak-free connection of a concentrate container to a blood processing device - Google Patents
System and method for leak-free connection of a concentrate container to a blood processing device Download PDFInfo
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- CN112472894B CN112472894B CN201910866970.2A CN201910866970A CN112472894B CN 112472894 B CN112472894 B CN 112472894B CN 201910866970 A CN201910866970 A CN 201910866970A CN 112472894 B CN112472894 B CN 112472894B
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- 239000008280 blood Substances 0.000 title claims abstract description 268
- 210000004369 blood Anatomy 0.000 title claims abstract description 268
- 239000012141 concentrate Substances 0.000 title claims description 41
- 238000000034 method Methods 0.000 title claims description 20
- 239000012530 fluid Substances 0.000 claims abstract description 187
- 238000011282 treatment Methods 0.000 claims abstract description 160
- 235000008504 concentrate Nutrition 0.000 description 34
- 238000011010 flushing procedure Methods 0.000 description 21
- 239000007788 liquid Substances 0.000 description 10
- 235000014666 liquid concentrate Nutrition 0.000 description 10
- 239000012528 membrane Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 230000008878 coupling Effects 0.000 description 5
- 238000010168 coupling process Methods 0.000 description 5
- 238000005859 coupling reaction Methods 0.000 description 5
- 238000002425 crystallisation Methods 0.000 description 5
- 230000008025 crystallization Effects 0.000 description 5
- 235000014483 powder concentrate Nutrition 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 3
- 239000012190 activator Substances 0.000 description 3
- 238000000502 dialysis Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 238000009256 replacement therapy Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 208000036829 Device dislocation Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/26—Valves closing automatically on disconnecting the line and opening on reconnection thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
- A61M1/1666—Apparatus for preparing dialysates by dissolving solids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
- A61M1/1668—Details of containers
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- External Artificial Organs (AREA)
Abstract
The present invention relates to a container comprising a connecting portion allowing a simple, efficient and more hygienic connection of the container to a fluid dosing unit of a blood treatment device. According to the invention, the fluid dosing unit comprises a valve which fluidly closes the fluid dosing unit without a container being connected to the fluid dosing unit and opens the fluid dosing unit when a container is connected to the fluid dosing unit. Thus, undesired spillage that may occur when the container is disconnected from the fluid dosing unit may be avoided.
Description
Technical Field
The present invention relates to a system and a method for connecting a concentrate container with a blood treatment device and/or a fluid dosing unit. Other aspects of the invention relate to a container and a fluid dosing unit/blood treatment device, preferably a dialysis machine for kidney replacement therapy, configured for use in the method according to the invention.
More particularly, the present invention relates to a container comprising a connecting portion allowing a simple, efficient and more hygienic connection of the container to a fluid dosing unit of a blood treatment device. According to the invention, the fluid dosing unit comprises a valve which fluidly closes the fluid dosing unit without a container being connected to the fluid dosing unit and opens the fluid dosing unit when a container is connected to the fluid dosing unit.
Background
For chronic blood treatment, in particular for chronic dialysis, almost exclusively bicarbonate-based dialysis solutions are now used, which are produced during the treatment by the blood treatment device itself/online by diluting the acidic and basic concentrates, preferably the powder concentrate, with water. Thus, it has been established to produce alkaline concentrate on-line during the treatment, i.e. to produce liquid alkaline concentrate continuously during the treatment by diluting the dry concentrate/powder concentrate with water.
For this purpose, dry powder concentrate is typically provided in a container that is fluidly coupled to the blood processing device such that water may be dispensed into the container through the blood processing device to dissolve the dry concentrate. At the same time, the alkaline liquid concentrate/bicarbonate solution produced in this way is drawn out of the concentrate container by the blood treatment device. Such a conventional concentrate container is known, for example, from EP 1344550.
In conventional blood processing apparatuses known in the prior art, the concentrate container cannot be connected to the hydraulic/fluid system of the blood processing apparatus during the disinfection/flushing of the blood processing apparatus.
For this reason, medical personnel must connect the concentrate container to the blood treatment device after disinfection/flushing of the blood treatment device and before preparing/priming the extracorporeal circuit of the blood treatment device for treatment.
In order to connect the concentrate container to the blood treatment device after disinfection/flushing of the blood treatment device and before preparing/priming the extracorporeal circuit of the blood treatment device for treatment, a certain amount of force is required to connect the container to the blood treatment device.
In order to make the blood treatment device and the concentrate container as user-friendly as possible, typically the blood treatment machine and the corresponding concentrate container are configured such that the connecting element of the container is inserted into the connecting element of the machine in a downward movement, such that gravity assists the movement of the connecting element of the container into/onto the connecting element of the machine.
However, a disadvantage of this configuration is that, since the opening of the connecting element of the container is open in a downward direction (such that the connecting element of the container can be coupled with a corresponding connecting element of the blood processing apparatus by moving the connecting element of the container from above when the connecting element of the blood processing apparatus is moved downward), liquid concentrate may drip from the connecting element of the container after the processing is completed and the concentrate container is removed from the blood processing apparatus.
In addition, in blood processing apparatuses according to the prior art, liquid concentrate may spill, leak or drip from the withdrawal line of the blood processing apparatus, which is configured to withdraw concentrate from the container when the container is disconnected from the blood processing apparatus. Since liquid concentrates contain solutes, crystallization can occur, and the further disadvantage of these spills is often unhygienic.
These liquid concentrates may collect in the connecting elements of the blood treatment apparatus, causing unwanted crystallization and thus may clog the connecting elements of the blood treatment apparatus.
Disclosure of Invention
It is therefore an object of the present invention to provide a container and/or a system comprising a container and a fluid dosing system/blood treatment device which avoids such undesired spillage/dripping of liquid concentrate during removal of the container from the blood treatment device, thereby improving hygiene.
This object is solved by the present invention. The present invention uses a container to collect any liquid droplets that drip from the connecting element of the blood processing apparatus and/or to prevent such droplets/spills/leaks in the first place. For this purpose, the opening element of the container according to the invention is preferably open in an upward direction, so that the connecting element of the blood treatment device can be inserted into the opening element of the container by a downward movement from above, or the container can be moved by an upward movement so that the connecting element of the blood treatment device can be inserted into the opening element of the container.
Furthermore, according to the invention, a valve is provided at the fluid dosing unit/blood treatment device, which valve fluidly closes the fluid dosing unit/blood treatment device without a container connected to the fluid dosing unit/blood treatment device, such that no liquid drips from the fluid dosing unit/blood treatment device without a container.
Another advantage of the present invention is that the container can be connected to the blood treatment device at any point in time such that the blood treatment device is properly positioned for subsequent connection to the container when needed.
Furthermore, the present invention provides a container that is easier and cheaper to manufacture, as fluid flows from the blood treatment device along the connecting element in the form of a linear channel through the connecting portion of the container and into the container. In other words, the structure of the connecting portion of the container may be simplified compared to the prior art, wherein the connecting portion is typically connected to the blood processing device via a downward movement, which determines the design of the opening at the lower surface of the connecting portion. Thus, according to the prior art, the fluid flowing through the connecting portion of the container is not strictly linear/unidirectional, but the fluid is diverted in multiple directions, which requires more complex designs and more material.
In addition to this, the structure of the container according to the invention, in particular of the connecting portion thereof, allows the filter to be more easily fitted into the opening of the fluid inlet and/or outlet of the container.
A container for concentrate according to an aspect of the present invention comprises: a body for containing a concentrate; at least one attachment element configured to reversibly attach the container to a corresponding at least one attachment element provided on a blood processing apparatus; and at least one connecting element configured to interact with a corresponding at least one connecting element provided on the blood processing apparatus to fluidly couple the container with the blood processing apparatus, wherein the at least one attaching element protrudes in a first direction and the at least one connecting element protrudes in a second direction oriented substantially at right angles to the first direction.
According to a preferred embodiment, the first direction in which the at least one attachment element protrudes is oriented substantially at right angles to the longitudinal axis of the body of the container. The attachment element of the blood device is preferably inserted into the attachment element of the container along a first direction. If the attachment elements of the container are hook-shaped, the attachment elements of the blood treatment device that are inserted into the hook-shaped attachment elements of the container preferably protrude in the first direction.
Furthermore, it has proven to be advantageous if the second direction in which the at least one connecting element protrudes is oriented substantially parallel to the longitudinal axis of the body of the container, and the at least one connecting element has the form of a hollow cylindrical piece which is open at the end face of the container opposite the body of the container, and is configured to receive a corresponding connecting element of the blood treatment device, such as a mouthpiece. The at least one connecting element of the container preferably has an opening at a flat (top) end face of the container facing away from the body of the container.
Preferably, at least one connecting element of the container, which may be used as an inlet for guiding fluid into the container or as an outlet for removing fluid from the container, protrudes through the connecting portion of the container in a straight line from a flat (top) end surface of the container facing away from the body of the container to an end surface of the connecting portion facing the body of the container.
Preferably, the container has two connecting elements each serving as an inlet and an outlet, each connecting element protruding through the connecting portion of the container in a straight line from a flat (top) end face of the container facing away from the body of the container to an end face of the connecting portion facing the body of the container.
In the outlet and/or the inlet, the fluid permeable activator may be arranged to open a valve in a respective connecting element of a fluid dosing unit, e.g. a fluid dosing unit of a blood processing device, when the container is connected to the fluid dosing unit.
According to a preferred embodiment of the invention, the container comprises two attachment elements, each formed as a hook, configured to hook onto a corresponding attachment element provided on the blood treatment device, the corresponding attachment element preferably being formed as a stud for receiving the hook of the container for reversibly attaching the container to the blood treatment device, the stud preferably comprising a circumferential groove.
According to an alternative embodiment of the invention, the container comprises two attachment elements, each formed as a hollow cylinder configured to receive a corresponding attachment element provided on the blood treatment device, the corresponding attachment element being formed as a stud to be inserted into the hollow cylinder of the container to reversibly attach the container to the blood treatment device.
According to another aspect of the invention, the container comprises the following two connecting elements: the two connecting elements are in the form of hollow cylinders that open at the end face of the container opposite/facing away from the body of the container, and are configured to receive corresponding connecting elements of a blood processing device, such as a mouthpiece, wherein the mouthpiece of the blood processing device is inserted into each hollow cylinder in a direction protruding from the end face of the container opposite the body of the container towards the body of the container.
In order to ensure the storage stability of the concentrate contained within the container, at least the connecting element is advantageously sealed by a cap, which is removably attached to the end face of the container opposite/facing away from the body of the container, the cap preferably being in the form of a flexible film.
For example, the cap may be glued or welded to the end face of the container opposite the body of the container. When the container is attached and connected to the blood treatment device, the end face of the opening comprising the at least one connection element of the container preferably faces the at least one connection element of the blood treatment device and forms a top end face of the container.
In order to make the container more user friendly, the flexible film forming the cap preferably comprises a surface configured to be easily peeled off from the end face of the container. In other words, the surface of the flexible film is surface treated to allow a user to easily peel the flexible film from the end face of the container, thereby exposing the at least one connecting element of the container, such as the central opening of the container, through which the container can be filled with dry concentrate.
To ensure proper mounting of the container to the blood processing device, the container may be configured to attach to the blood processing device according to a lock and key configuration. To this end, the container may comprise the following two attachment elements: the two attachment elements are formed in different sizes and/or geometric configurations to allow the container to be attached to the blood processing device in only one defined mounting position. The blood processing apparatus in this embodiment preferably comprises two corresponding attachment elements of different sizes and/or geometric configurations.
Alternatively or additionally, the container or the blood treatment device may comprise the following two connection elements: the two connecting elements are formed in different sizes and/or geometric configurations to allow the container to be fluidly coupled to the blood processing device in only one defined mounting position. The blood processing apparatus or container in this embodiment preferably comprises two corresponding connecting elements.
The number of attachment elements and/or connection elements provided on the container and/or blood processing apparatus is arbitrary and may vary depending on the particular application.
According to a preferred embodiment of the invention, a fluid permeable applicator is provided in the connecting element of the container, which fluid permeable applicator opens a valve in a corresponding connecting element of a fluid dosing unit, e.g. of a blood processing device, when the container is connected to the fluid dosing unit.
For example, the fluid permeable applicator comprises a spike that removes the valve body from the valve seat when the container is connected to the fluid dosing unit. To be fluid permeable, the fluid permeable applicator preferably comprises at least one lumen for guiding a fluid.
Another aspect of the invention relates to a blood treatment device and/or a fluid dosing unit, preferably a blood treatment device comprising a fluid dosing unit, configured for use with a container according to the invention.
The blood processing apparatus includes: a main body; at least one attachment element to which a corresponding attachment element for a container of concentrate can be attached, wherein the at least one attachment element is movable relative to the body in a direction protruding substantially at right angles to a side surface of the body; and at least one connecting element configured to fluidly couple the blood processing apparatus to a container for the concentrate. The body of the blood processing apparatus includes a top surface, a bottom surface, and four side surfaces. Depending on the viewing direction of the user, the side surface of the blood processing device may also be referred to as the front surface.
In a preferred embodiment of the invention, the at least one attachment element of the blood treatment device has the form of a pin or stud protruding outwards from the side surface of the body, and the at least one connection element has the form of a spout protruding in a direction substantially parallel to the side surface of the body.
It has proven to be advantageous if the blood treatment device further comprises a movable and/or motorized guiding element, preferably a cavity is formed in the guiding element, and the at least one attachment element is mounted to the movable and preferably motorized guiding element. The guide element is movable to a first position in which the at least one connecting element of the blood treatment device, preferably a mouthpiece for fluidly connecting the blood treatment device to a container, is received in a cavity provided on the guide element, allowing for flushing of the blood treatment device.
In the first position, the lumen in the guiding element shorts and/or closes the internal fluid circuit of the blood treatment device to form a closed circuit, so that the flushing liquid can circulate in the blood treatment device.
The guiding element may also be movable to a second position in which the mouthpiece is fluidly connected with a container attached to the at least one attachment element of the blood processing apparatus. The guiding element is preferably movable in a horizontal and/or vertical direction.
In the second position, the guiding element preferably positions the container, in particular the at least one connecting element of the container, attached to the at least one attachment element mounted on the guiding element relative to the at least one connecting element of the blood processing device such that the container is fluidly coupled to the blood processing device.
The guide element may be movable by a motor of the blood processing apparatus. In this case, the movement of the guide element is preferably automatic. Alternatively, the guiding element may be moved manually. In this case, the blood processing apparatus preferably has a lever or similar structure that allows the user to manually move the guide element.
Preferably, the at least one connecting element of the blood processing apparatus, such as a mouthpiece, is movable in a vertical direction substantially parallel to a side surface of the body of the blood processing apparatus.
In a preferred embodiment, the at least one connecting element of the blood processing apparatus is movable in a downward direction towards a bottom surface of a body of the blood processing apparatus. Additionally or alternatively, the at least one connecting element of the blood processing apparatus is movable in an upward direction towards a top surface of a body of the blood processing apparatus.
For example, the at least one connecting element of the blood treatment apparatus may first be moved upwards to allow the container attached to the attachment element to be moved by the guiding element to the following positions: in this position, the at least one connecting element of the blood processing apparatus is aligned in a vertical direction with the at least one connecting element of the container.
The at least one connecting element of the blood processing apparatus may then be moved downwardly towards the guiding element to fluidly couple the container to the blood processing apparatus, for example by inserting the at least one connecting element of the blood processing apparatus into the at least one connecting element of the container.
At a later stage, for example, after the concentrate contained in the container has been exhausted, the at least one connecting element of the blood processing apparatus may again be retracted upwardly to withdraw the at least one connecting element of the blood processing apparatus from the at least one connecting element of the container, thereby fluidly separating the container and the blood processing apparatus from each other.
The blood processing apparatus preferably further comprises a protruding portion provided on a side surface of the main body. The guide element is preferably movable in relation to the protruding part in the manner of a drawer. In other words, the guiding element may be slidably movable with respect to the protruding portion in a direction substantially at right angles to the side surface of the blood processing device, i.e. in a horizontal direction.
Preferably, the at least one connecting element of the blood treatment device is mounted to the protruding portion and is movable in a direction substantially parallel to the side surface of the blood treatment device to protrude from the protruding portion (preferably protruding downwards in a vertical direction towards the bottom surface of the blood treatment device). It is also preferred that the at least one connecting element of the blood treatment device is retractable/movable into the protruding portion in a vertical direction substantially parallel to the side surface of the blood treatment device.
The movement of the guiding element and/or the at least one connecting element of the blood treatment apparatus may be performed automatically or non-automatically, mechanically and/or manually.
According to a preferred aspect of the invention, the blood treatment device comprises two attachment elements, each formed as a pin/stud, preferably comprising a circumferential groove, for receiving a corresponding attachment element of the container, preferably formed as a hook, for reversibly attaching the container to the blood treatment device. The hooks may be inserted into the circumferential groove to prevent slippage.
In order to ensure that the container is properly mounted to the blood treatment device in only one possible mounting position, the blood treatment device preferably comprises two attachment elements that are formed in different sizes and/or geometric configurations to allow the container to be attached to the blood treatment device in only one defined mounting position.
Alternatively or additionally, the blood treatment device may comprise two connecting elements formed in different sizes and/or geometric configurations to allow the container to be fluidly coupled to the blood treatment device in only one defined mounting position.
In order to prevent undesired dripping of fluid/liquid from the connecting element/at least one connecting element of the blood treatment device, the connecting element may be provided with a valve which closes the connecting element without a container being attached to the connecting element and opens the connecting element to fluidly couple the connecting element with the container if the container is connected to the connecting element.
In an embodiment of the invention, the connecting element is a fluid line, such as a supply line or an extraction line, of a fluid dosing unit, preferably of a blood treatment device. Preferably, the connecting element is an extraction line of the fluid dosing unit.
Throughout this application, reference is made to a blood treatment device comprising a fluid dosing unit connectable to a container comprising a dry concentrate for dispensing fluid into the container and withdrawing fluid from the container. However, the invention is not limited to blood treatment devices, but may be applied to any fluid dosing unit.
According to a preferred embodiment of the invention, the fluid dosing unit comprises a valve in the connecting element/fluid line (preferably in the withdrawal line), wherein the valve comprises a valve body which is movable in the axial direction between a closed position (valve body in contact with the valve seat) and an open position (valve body removed from the valve seat). In the open position, fluid may flow from the connecting element/fluid line through the valve into the container. The valve is biased into the closed position, for example by means of a spring.
Preferably, the valve is opened by means of a fluid permeable effector provided in a connecting element of the container, wherein the connecting element serves as an inlet or outlet for fluid into or out of the container. It has proven advantageous to provide a fluid permeable applicator in the outlet of the container, because: the fluid path contains concentrate (rather than water being dispensed into the container through the inlet) which causes crystallization in case of dripping of concentrate from the connecting element/fluid line of the fluid dosing unit. Particularly in the case where the fluid line is a withdrawal line for the flow of liquid concentrate (e.g. bicarbonate solution), crystallization due to spillage is a problem.
Another aspect of the invention relates to a system comprising at least one container according to the invention and at least one blood treatment device according to the invention.
Preferably, the container is reversibly attached to the blood treatment device by means of at least one attachment element provided on the container, which interacts with at least one attachment element provided on the blood treatment device.
Additionally or alternatively, the at least one connecting element of the blood processing apparatus is fluidly coupled to the at least one connecting element of the container.
Another aspect of the invention relates to a method for connecting a container for concentrate, preferably according to the invention, to a blood treatment device, preferably according to the invention, the method comprising the steps of:
-reversibly attaching the container to the blood treatment device by means of at least one attachment element provided on the container and at least one attachment element provided on the blood treatment device;
-moving the container towards the body of the blood processing device in a horizontal direction/in a direction protruding substantially at right angles to a side surface of the body of the blood processing device;
-moving at least one connecting element of the blood treatment device and/or the container in a vertical direction/in a direction protruding substantially parallel to a side surface of a body of the blood treatment device, whereby the at least one connecting element of the blood treatment device is inserted into the at least one connecting element of the container, thereby fluidly coupling the container to the blood treatment device.
In order to prevent uncontrolled dripping of liquid from the at least one connection element of the blood treatment apparatus, which dripping may lead to contamination and/or crystallization on components of the blood treatment apparatus, the method may comprise the additional steps of: the container is used to capture any droplets or spills originating from the at least one connecting element of the blood processing apparatus.
These additional steps may be, for example:
-moving the at least one connection element of the blood treatment device and/or the container in a vertical direction/in a direction substantially parallel to the protrusion of the side surface of the body of the blood treatment device, thereby removing the at least one connection element of the blood treatment device inserted into the at least one connection element of the container from the at least one connection element of the container, thereby fluidly separating the container from the blood treatment device; and
-Suspending the movement of the container in the following positions: in this position, the at least one connecting element of the container is at least partially aligned with the at least one connecting element of the blood processing apparatus in a vertical direction/a direction protruding substantially parallel to a side surface of the body of the blood processing apparatus such that any liquid dripping from the at least one connecting element of the blood processing apparatus is received by the at least one connecting element of the container.
In other words, the container is not removed immediately after disconnecting the container from the blood processing apparatus, but remains vertically below the connecting element of the blood processing apparatus, such as the mouthpiece, for a period of time to capture any drops that fall downwardly from the connecting element.
Furthermore, the method may comprise a flushing step in which the blood treatment device is flushed before connecting the container to the blood treatment device or after disconnecting the container from the blood treatment device.
In this embodiment, the blood treatment apparatus preferably comprises a movable and/or motorized guiding element comprising the at least one attachment element of the blood treatment apparatus and further comprising a cavity configured to receive the at least one connection element of the blood treatment apparatus. The method further comprises the steps of:
-moving the guiding element to a flushing position in which the at least one connecting element of the blood treatment device is received in the cavity, thereby sealing the blood treatment device against external fluid and allowing flushing of the blood treatment device.
In other words, instead of inserting the connecting element of the blood processing device into the connecting element of the container to, for example, dispense water into the container to dissolve the concentrate powder to form the liquid concentrate, in the flushing position the connecting element of the blood processing device is inserted into the cavity of the guiding element.
Thus, the internal fluid circuit of the blood treatment apparatus is closed and the flushing fluid may circulate in the blood treatment apparatus.
Preferably, all method steps are performed by the blood treatment device, except for the step of reversibly attaching the container to the blood treatment device by means of at least one attachment element provided on the container and at least one attachment element provided on the blood treatment device.
This has the advantage that: no personnel are required to manually connect the container to the blood processing apparatus. Instead, the container may be attached to the blood processing apparatus at any convenient time (e.g., during normal operating time), and the blood processing apparatus establishes a fluid connection between the container and the blood processing apparatus as needed (on demand) at a particular point in time (e.g., at night) as determined, for example, by a treatment regimen.
In other words, the present invention can be described as follows:
one aspect of the invention relates to a container for concentrate, the container comprising: a body for containing a concentrate; a connecting portion having a flat end surface facing away from the main body and an opening through which the main body can be filled with concentrate; an inlet through which fluid may be supplied to the body; and an outlet through which fluid may be withdrawn from the body, wherein a fluid permeable applicator is provided at least in the outlet, the fluid permeable applicator being configured to open a valve in a fluid line of the fluid dosing unit when the container is connected to the fluid dosing unit to fluidly couple the container to the fluid dosing unit.
According to an embodiment of the invention, a fluid permeable applicator includes a spike configured to open a valve and at least one lumen for directing fluid.
Preferably, the outlet and the inlet each protrude along a straight line across the connecting portion from a planar end face facing away from the main body to a planar end face facing toward the main body.
According to another aspect of the invention, the container comprises two attachment elements provided at two opposite sides of the connection portion and configured to reversibly attach the container to two corresponding attachment elements present on the blood processing device, wherein the two attachment elements protrude in a first direction and the outlet and inlet protrude in a second direction, the second direction being oriented substantially at right angles to the first direction.
Preferably, the connecting portion is formed to be grip-less, and the connecting portion includes a concave grip portion.
Another aspect of the invention relates to a fluid dosing unit, preferably a fluid dosing unit of a blood treatment device, wherein a valve is provided at least in a fluid line (also referred to as "withdrawal line") of the fluid dosing device configured to withdraw fluid from a container connected to the fluid dosing unit, the valve being configured to fluidly close the fluid line without the container being connected to the fluid dosing unit, and the valve being further configured to be openable when the container is connected to the fluid dosing unit to allow withdrawal of fluid from the container through the valve.
The fluid dosing unit may be part of a blood treatment device, such as a dialysis machine for kidney replacement therapy.
In a preferred embodiment, the fluid line is an extraction line of a fluid dosing unit. In principle, however, the invention can also be applied to supply lines or other fluid lines of fluid metering units.
Preferably, the valve comprises an axially movable valve body which is removable from the valve seat when the container is connected to the fluid dosing unit to allow fluid to be drawn from the container through the valve.
Another aspect of the invention relates to a system comprising at least one container according to the invention and at least one fluid dosing unit/blood treatment device according to the invention, wherein preferably the container is reversibly attached to the fluid dosing unit/blood treatment device.
Another aspect of the invention relates to a method for connecting a container for concentrate, preferably according to the invention, to a fluid dosing unit, preferably according to the invention, the method comprising the steps of:
-reversibly attaching the container to the fluid dosing device by means of an attachment element present on the container and an attachment element present on the fluid dosing unit;
-moving the withdrawal lines of the container and/or the fluid dosing unit relative to each other such that the fluid permeable applicator in the outlet of the container opens a valve in the withdrawal line of the fluid dosing unit to fluidly couple the container to the blood processing device.
The withdrawal lines of the container and/or the fluid dosing unit are preferably moved relative to each other such that a fluid permeable actor is inserted into the withdrawal lines to move the axially movable valve body away from the valve seat to fluidly couple the container to the fluid dosing unit.
Drawings
Other features, advantages and technical effects of the present invention become apparent from the accompanying drawings showing preferred embodiments of the present invention. The drawings are only for the purpose of illustrating the invention and are not to be construed as limiting the invention. In the drawings, the same or similar components are denoted by the same reference numerals.
In the drawings:
fig. 1 shows an embodiment of a container according to the invention;
FIG. 2 shows another embodiment of a container according to the present invention that includes a peelable flexible film to seal the connecting elements of the container;
FIG. 3 shows how a user can peel the flexible film from the end face of the container;
FIG. 4 shows a state in which the user has almost completely removed the flexible film from the top end face of the container;
Figure 5 shows a connecting portion of a concentrate container according to the prior art;
FIG. 6 illustrates a connecting portion of a container according to an embodiment of the present invention;
FIG. 7 shows a side view of the connection portion of FIG. 5;
FIG. 8 shows a side view of the connection portion of FIG. 6;
FIG. 9 shows a cross-sectional view of the connection portion of FIG. 7;
FIG. 10 shows a cross-sectional view of the connection portion of FIG. 8;
FIG. 11 shows a top view of the connection portion of FIG. 5;
FIG. 12 shows another side view of the connection portion shown in FIG. 5;
FIG. 13 shows a top view of the connecting portion of FIG. 6;
FIG. 14 shows a different side view of the connecting portion of FIG. 6;
FIG. 15 shows a top perspective view of the connecting portion of FIG. 6;
FIG. 16 shows a detailed view of the flexible membrane sealed connection section of FIG. 6;
fig. 17 shows a blood treatment device according to the invention comprising two attachment elements;
Fig. 18 shows how the container is attached to the attachment element of the blood processing device of fig. 17;
FIG. 19 shows the blood processing apparatus of FIG. 17 with a container attached;
FIG. 20 shows a detailed view of the blood processing apparatus of FIG. 17 with the guide member positioned in a closed flush position relative to the projection;
FIG. 21 shows a side view of the blood processing machine of FIG. 17 with the guide member positioned in a closed flush position relative to the projection;
Fig. 22 shows the blood processing apparatus of fig. 21, wherein the container is attached to an attachment element of the blood processing apparatus;
fig. 23 shows a cross-sectional view illustrating the flushing position of the guide element relative to the protruding part;
fig. 24 shows a perspective view of a container attached to an attachment element of a blood processing device in a closed flush position;
Fig. 25 shows the container connected to the blood processing apparatus in the following positions: in which the container is fluidly coupled to the blood processing apparatus;
FIG. 26 shows a cross-sectional view of the arrangement of FIG. 25;
FIG. 27 illustrates a blood processing apparatus fluidly coupled to a container;
FIG. 28 shows the blood processing apparatus of FIG. 27 in a flush position;
FIG. 29 shows the guide element and protruding portion of the blood processing apparatus in a closed flush position;
FIG. 30 shows the arrangement of FIG. 29 with a container already attached;
FIG. 31 illustrates the position in which the container is fluidly coupled to the blood processing apparatus;
FIG. 32 shows how the container attaches to an accessory element of a blood processing apparatus;
FIG. 33 illustrates how the guide element moves inwardly toward a side surface of the body of the blood processing apparatus to position the container in a position capable of fluidly coupling with a connecting element of the blood processing apparatus;
fig. 34 shows the position of the connecting element of the blood processing device and the connecting element of the container aligned in the vertical direction;
FIG. 35 shows how the container is moved upward to insert the connecting element of the blood processing apparatus into the connecting element of the container;
FIG. 36 illustrates the position of a container fluidly coupled to a blood processing apparatus during blood processing;
FIG. 37 shows how the container is moved downward after the treatment is completed to fluidly separate the connecting element of the container from the connecting element of the blood treatment apparatus;
FIG. 38 shows how the container is held in a position in which the connecting element of the blood processing apparatus and the connecting element of the container are fluidly coupled but vertically aligned;
FIG. 39 illustrates how droplets falling from a connecting element of a blood processing device are captured by a concentration bag;
FIG. 40 shows how the container is removed from the blood processing apparatus after the end of the process by moving the container away from the side surface of the blood processing apparatus;
FIG. 41 shows how the container may be removed from the blood processing apparatus after the process has ended;
FIG. 42 shows how the guide element is then moved to the flushing position by aligning a lumen provided on the guide element with a connecting element of the blood processing apparatus in a vertical direction; and
FIG. 43 illustrates the guide element in a flushing position in which the connecting element is inserted into a flushing lumen provided in the guide element;
fig. 44 shows an embodiment in which the guide element can be moved manually using the lever 21;
fig. 45 shows a cross-sectional view of an embodiment of a fluid dosing unit of a blood treatment device equipped with an integrated valve for preventing fluid from dripping from the fluid dosing unit without a container connected to the fluid dosing unit;
fig. 46 and 47 show cross-sectional views of the embodiment of fig. 45 in a state in which the container is connected to the fluid dosing unit and the valve is opened;
FIG. 48 shows a cross-sectional view of the embodiment of FIG. 45 in a state in which no container is connected to the fluid dosing unit and the valve is closed;
Fig. 49 shows a detailed view of a fluid permeable applicator which may be provided at a container according to the invention to open a valve of a fluid dosing unit as shown in fig. 45;
Fig. 50 shows a cross-sectional view of the fluid permeable applicator of fig. 49.
Detailed Description
As shown in fig. 1, the container 1 comprises a body 2, the body 2 being configured to contain a dry and/or liquid concentrate. Furthermore, the container 1 comprises two attachment elements 3 in the form of hooks, which attachment elements 3 are arranged on opposite sides of the attachment portion 4 of the container 1.
Furthermore, the container 1 comprises a connecting element 5, the connecting element 5 being open towards a top end face 6 of the connecting portion 4 of the container 1 opposite/facing away from the body 2. In this embodiment, the container further comprises a handle 22 allowing the user to grasp the container 1. The top end face 6 is sealed by a flexible membrane 7, the flexible membrane 7 covering the connecting element 5 and the central opening 8 of the connecting portion 4.
Fig. 2 shows another container 1 according to the invention. In this embodiment, the flexible membrane seals the connecting element 5 but does not completely cover the central opening 8. Furthermore, in this embodiment, the attachment element 3 takes the form of a hollow cylinder configured to receive a corresponding stud/pin of the blood treatment device.
Fig. 3 shows the user peeling the flexible film 7 from the top end face 6 of the container 1. As in all the figures, the components denoted by the same reference numerals are the same or similar components.
In the state shown in fig. 4, the user removes the flexible film 7 almost completely from the top end face 6 of the container 1.
Fig. 5 shows a connecting portion 4 of a concentrate container known from the prior art. Such conventional connecting parts of containers known in the prior art generally comprise connecting elements 5, the connecting elements 5 being open downwards so that liquid can drip from these connecting parts into connecting elements provided on the blood treatment device, which are configured to be inserted into the connecting elements 5. The attachment portion further includes a handle 22 that allows a user to grasp the attachment portion.
Fig. 6 shows a connecting portion 4 of a container according to the invention. The connection portion comprises an attachment element 3, the attachment element 3 being formed as a hollow cylinder and being configured to receive a corresponding connection element provided on the blood treatment device, in particular in the form of a stud, a pin or a cylinder.
The connecting portion 4 further comprises a connecting element 5, the connecting element 5 opening upwards towards a top end face 6 of the connecting portion.
According to this embodiment, the connecting portion 4 further comprises a grip portion 8 at the opposite side of the connecting portion 4, which replaces the handle 22 provided in the conventional connecting portion shown in fig. 5.
Fig. 7 shows a connecting part 4 according to the prior art in a side view, which shows a connecting element 5 and a handle 22. In contrast, the connecting portion 4 of the container according to the invention shown in fig. 8 comprises an attachment element 3, which attachment element 3 is arranged on the opposite side of the connecting portion 4 and is formed as a hollow cylinder. The opening of the connecting portion is not visible in this view.
Fig. 9 shows a cross-sectional view of the connecting part 4 of fig. 7, wherein the handle 22 is clearly visible. In the sectional view of the connecting portion 4 according to the invention in fig. 10, the grip portion 9 as well as the attachment element 3 and the connecting element 5 are clearly visible, the attachment element 3 and the connecting element 5 being open towards the top end face 6 of the connecting portion 4.
As can be seen from fig. 11, the connecting element 5 of the connecting portion 4 according to the prior art also serves as an attachment element, since the connecting element 5 in the form of a hollow cylindrical piece is provided on a corresponding mouthpiece of the blood treatment device.
This is further illustrated in the view of fig. 12, whereby it can be seen that the attachment element of the blood treatment apparatus, i.e. the connection element of the blood treatment apparatus according to the prior art, is inserted into the connection element 5 of the connection part 4 in a substantially vertical position/orientation in fig. 12, allowing liquid from the connection element 5 to drip out of the connection element 5 of the connection part 4 of the container 1.
As shown in fig. 13, according to the invention, the attachment element 3 and the connection element 5 are separated from each other. From the slave
It can also be easily seen in fig. 13 that the attachment element 3 and the connection element 5 are arranged relative to each other, because the attachment element 3 and the connection element 5 protrude in directions arranged substantially at right angles to each other, preferably in directions arranged horizontally and vertically, respectively.
In the example of fig. 13, the attachment element protrudes in a direction from the top of fig. 13 to the bottom of fig. 13, whereas the connection element 5 is an opening protruding or extending in a direction into and out of the plane of the paper.
Fig. 14 provides another clear view of the grip portion 9, which may replace the handle 22 provided in the connecting portion 4 as known in the prior art.
Fig. 15 also illustrates how the direction of extension of the attachment element 3 is arranged substantially at right angles to the direction of extension of the connecting element/opening 5.
As can be seen in fig. 16, the connecting element 5 is preferably sealed by a flexible strip 7, the flexible strip 7 preferably being welded to the top end face 6 of the connecting portion 4 to close the connecting element 5.
Preferably, the flexible membrane 7 comprises a gripping section 10, the gripping section 10 allowing a user to grip the flexible membrane 7 to remove the flexible membrane 7 from the top end face 6 of the connecting portion 4 of the container 1.
As can be seen in fig. 17, the blood treatment device 11 according to the invention comprises a main body 12, the main body 12 having a bottom surface 13 and an attachment assembly 14, the attachment assembly 14 being configured for attachment and connection to the container 1.
The attachment assembly 14 comprises a guide element 15 to which guide element 15 two attachment elements 16 are mounted, in this embodiment the attachment elements 16 having the form of protruding cylinders/studs/pins and each having a circumferential groove into which the hook or hook-like attachment element 3 of the container 1 can be inserted.
The attachment assembly 14 further includes a protruding portion 17. In the configuration shown in fig. 17, the front surface 18 of the protruding portion 17 and the front surface 19 of the guiding element 15 are aligned with each other to form a continuous front surface of the attachment assembly 14. This corresponds to the flushing position.
As can be seen in fig. 18, the bag 1 can be attached by means of the hook-shaped attachment elements 3 to the screw-shaped attachment elements 16 mounted on the guide element 15.
Fig. 19 shows a blood treatment device 11, wherein the container 1 is attached to the attachment element 16 of the guiding element 15. The container 1 is in its position of fluid coupling with a blood treatment device.
Fig. 20 shows the attachment assembly 14 of the blood treatment apparatus 11, wherein the guiding element 15 is arranged in a closed position for flushing the blood treatment apparatus relative to the protruding portion 17.
In this position, the front surface 18 of the protruding portion 17 and the front surface 19 of the guiding element 15 form a continuous front surface. The flushing position of the guide element 15 relative to the protruding portion 17 is further shown in the side view of the blood treatment device 11 shown in fig. 21. It becomes particularly clear in this figure that in the closed position/flushing position of the guide element relative to the protruding portion 17, the front end face 18 of the protruding portion 17 and the front end face 19 of the guide element 19 form a continuous front end face.
Fig. 22 shows the blood treatment apparatus of fig. 21, wherein the container 1 is attached to the attachment element 16 of the blood treatment apparatus via its attachment element 3. This position is adopted when the blood treatment apparatus is flushed/disinfected by an internal circulation but is ready for the next blood treatment by providing the container 1. The container 1 will be fluidly connected to the blood treatment device 11 before starting the next blood treatment.
Fig. 23 illustrates in more detail the structural configuration of the attachment assembly 14 of the blood processing apparatus by providing a cross-section of the attachment assembly 14 in the closed/flush position shown in fig. 21 and 22. As in
As can be seen in fig. 23, the front face 18 of the protruding portion 17 and the front face 19 of the guiding element 15 provide a continuous front surface.
In this relative positioning, a connecting element 20, which in the embodiment of fig. 23 has a mouthpiece-type blood treatment device for dispensing water into the container 1, is inserted into a cavity 18 provided in the guide element 15. Thus, the internal fluid system of the blood treatment apparatus is closed from the outside and the flushing fluid may circulate within the blood treatment apparatus without fluid leaking from the mouthpiece 17 to the outside of the blood treatment apparatus 11.
Fig. 24 shows a close-up view of the connection assembly 14 of the blood treatment apparatus 11, wherein the container 1 has been attached via the attachment elements 3 and 16. The connection assembly 14 is in the closed/flush position.
To fluidly couple the container 1 to the connection assembly 14 and thus to the blood processing device 11, the guide element 15 is then moved inwardly towards the side surface of the blood processing device 11, as shown in fig. 25. Thus, the container 1 attached to the attachment element 16 of the blood treatment device 11 is moved towards the side surface of the blood treatment device 11 until the container 1 is arranged below the protruding portion 17 and the connecting element 5 of the bag 1 is horizontally aligned with the connecting element 20 of the blood treatment device.
As shown in fig. 26, the guide element 15 and thus the container 1 attached to the attachment element 16 mounted on the guide element 15 is moved upwards to connect the connecting element 5 of the container 1 with the connecting element 20 of the blood treatment device. Alternatively, the container 1 may be held stationary by the guiding element 15 and the connecting element 20 of the blood treatment device moved downwards for insertion into the connecting element 5 of the container 1, thereby fluidly coupling the container 1 to the blood treatment device 11.
Fig. 27 shows a side view of the blood treatment apparatus wherein the container 1 is fluidly coupled to the blood treatment apparatus 11 in the position/relative positioning shown in fig. 26.
Fig. 28 shows a side view of the blood processing apparatus 11 with the attachment assembly 24 in the position shown in fig. 24.
Fig. 29 shows another view of the connection assembly 14 of the blood processing apparatus in a closed flush position.
Fig. 30 shows the attachment assembly 14 of fig. 29, wherein the container 1 has been attached via its attachment element 3 (hook-shaped) and the attachment element 16 (stud-shaped) of the blood treatment device. In this depiction, the attachment assembly 14 is still in the closed flush position.
Fig. 31 shows the attachment assembly 14, wherein the container 1 has been moved inwardly under the protruding portion 17 and fluidly coupled to the blood treatment device by inserting the connecting element of the blood treatment device into the connecting element of the container 1, either by moving the container 1 upwards towards the protruding portion 17 or by moving the connecting element 20 of the blood treatment device downwards into the connecting element 5 of the container 1.
Next, a method of connecting a container for concentrate to a blood processing device according to the present invention will be described.
As shown in fig. 32, the attachment element 16 of the blood treatment apparatus is inserted into the attachment element 3 of the container 1. As can be seen in fig. 32, the attachment element 16 of the blood treatment device and the attachment element 3 of the container are asymmetrically configured to allow the container to be mounted to the blood treatment device in only one correct mounting position.
Fig. 33 shows the container 1 connected to the attachment element 16 of the blood treatment apparatus via the attachment element 3 of the container. Then, the guide member 15 is moved inward in the horizontal direction toward the side surface of the blood processing apparatus 11 to pull the container 1 below the protruding portion 17, as shown in fig. 34.
As can also be seen from fig. 34, the connecting element 20 and the connecting element 5 of the blood treatment apparatus are aligned in this position in the vertical direction, so that the connecting element 20 can be inserted into the connecting element 5 of the container 1 by a movement along the vertical axis.
As shown in fig. 35, the connecting element 20 of the blood treatment device can be inserted/plugged into the connecting element 5 of the container 1 by moving the guiding element 15 and thus the container 1 upwards towards the protruding portion 17. Alternatively, the connecting element 20 of the blood treatment device may be moved downwards to be inserted into the connecting element 5 of the container 1.
When the container 1 is fluidly coupled to the blood treatment device via the connection element 20 and the connection element 5, as shown in fig. 36, the treatment may be performed by a blood treatment machine that produces a liquid concentrate from a powder concentrate contained within the body 2 of the container 1.
After the process is completed, the guiding element 15 and thus the container 1 attached thereto is moved downwards, as shown in fig. 37. The container 1 continues to move downwards until the connecting element 20 of the blood treatment device is removed from the connecting element 5 of the container 1, as shown in fig. 38.
The guide element 15 and thus the container 1 to which it is attached is then moved outwards in a horizontal direction similar to a drawer of the side surface of the blood treatment apparatus 11.
As shown in fig. 39, the movement of the container 1 may be paused in a position in which the container 1 is vertically aligned with the connecting element 20 of the blood processing apparatus such that any liquid droplets that fall from the connecting element 20 of the blood processing apparatus are caught by the container 1, preferably by the connecting element 5 of the container 1.
As shown in fig. 40, the container 1 is then moved by means of moving the guide element 15 relative to the protruding portion 17 until the container 1 is positioned farther away/farther away from the side surface of the blood processing device 11 than the front edge of the protruding portion 17. This allows the user to easily grasp the container 1.
As shown in fig. 41, the container 1 can be easily disconnected from the attachment element 16 of the blood treatment apparatus by pulling the container 1 away from the blood treatment apparatus 11.
After removal of the container 1, the blood processing machine may then move the guiding element 15 upwards and/or inwards towards the side surface of the blood processing device 11 until the connecting element 20 of the blood processing device is vertically aligned with the cavity 18 of the guiding element 15, as shown in fig. 42.
In this position, the blood processing apparatus may be brought into a closed/flushing position. As shown in fig. 43, the guide member 15 is moved further upward or the connecting member 20 of the blood processing apparatus 11 is moved further downward to insert the connecting member 20 into the lumen 18 of the guide member 15 to enter the closed flush position.
The blood processing machine can now be flushed and a new concentration bag can be attached to the guide element 15 during flushing by using the attachment element 16 to start a new process.
All movements of the guide element 15 relative to the protruding portion 17 may also be performed manually. For this purpose, the attachment assembly 14 of the blood treatment apparatus may comprise a lever 21 as shown in fig. 44 or similar structure allowing the user to manually move the guiding element with respect to the protruding portion 17.
Fig. 45 shows a cross-sectional view of an embodiment of the fluid dosing unit of the blood treatment device equipped with an integrated valve 23 for preventing fluid from dripping from the fluid dosing unit/coupling element 20 of the fluid dosing unit without a container 1 being connected to the fluid dosing unit.
The fluid dosing unit in this example corresponds to the attachment assembly 14 discussed above. The term "fluid dosing unit" refers to any unit for connecting to a container and dispensing fluid into the container and withdrawing fluid from the container in a controlled manner.
The valve comprises a valve body 24 and a valve seat 25. The valve 23 is biased into the closed position by means of a biasing element, in this embodiment by a spring 26.
In the state shown in fig. 45, the container 1 is attached to and fluidly coupled to the fluid dosing unit such that the valve 23 is opened.
Fig. 46 and 47 show cross-sectional views of the embodiment of fig. 45 in a state in which the container is connected to the fluid dosing unit and the valve is opened. As shown in fig. 46, the fluid permeable activator 27 comprising the spike 28 holds the valve 23 in an open position such that fluid can flow through the inner lumen 29 of the fluid permeable activator 27, through the open valve 23 and through the connecting element 20 of the fluid dosing unit. The connecting element 20 in this embodiment corresponds to a fluid line of a fluid dosing unit. The flow path of the fluid in this state is indicated by the line in fig. 47. The valve body 24 may include a recess 30 for receiving the spike 28.
Fig. 48 shows a cross-sectional view of the embodiment of fig. 45 in a state in which no container is connected to the fluid dosing unit and the valve 23 is closed. In this state, the spring 26 expands and presses the valve body 24 against the valve seat 25.
Fig. 49 shows a detailed view of a fluid permeable applicator 27, which fluid permeable applicator 27 may be arranged at a container 1 according to the invention to open a valve 23 of a fluid dosing unit as shown in fig. 45. The fluid permeable applicator 27 comprises spikes 28 and the fluid permeable applicator 27 in this embodiment comprises four lumens 29 for guiding the fluid. The fluid permeable applicator 27 includes an outer liner/hollow cylinder 31 defining the outer periphery of the fluid permeable applicator 27. Spike 28 may be mounted to a platform 32, with platform 32 disposed concentric with outer sleeve/hollow cylinder 31 and connected to outer sleeve/hollow cylinder 31 via ribs 33. A fluid permeable applicator 27 is provided in the connecting element 5 of the container. The connecting element 5 may be an inlet or an outlet of the container.
Fig. 50 shows a cross-sectional view of the fluid permeable applicator 27 of fig. 49.
Claims (11)
1. A container for concentrate, the container comprising:
a body for containing the concentrate,
A connecting portion having a planar end face facing away from the body and an opening through which the body can be filled with concentrate,
An inlet through which fluid can be supplied to the body, and
An outlet through which fluid can be withdrawn from the body, wherein a fluid permeable applicator is provided at least in the outlet, the fluid permeable applicator being configured to open a valve in a fluid line of the fluid dosing unit when the container is connected to the fluid dosing unit to fluidly couple the container to the fluid dosing unit, wherein the fluid permeable applicator comprises a spike configured to open the valve and at least one lumen for guiding fluid,
Wherein the container is configured for dry concentrate.
2. The container of claim 1, wherein the outlet and the inlet each protrude along a straight line across the connecting portion from the planar end face facing away from the body to a planar end face facing toward the body.
3. Container according to claim 1 or 2, wherein the container comprises two attachment elements provided at two opposite sides of the connection portion and configured to reversibly attach the container to two corresponding attachment elements present on a blood treatment device, wherein,
The two attachment elements protrude in a first direction and the outlet and the inlet protrude in a second direction, the second direction being oriented substantially at right angles to the first direction.
4. A container according to claim 1 or 2, wherein the connecting portion is formed as a grip-less and comprises a concave gripping portion.
5. A fluid dosing unit, wherein a valve is provided at least in a fluid line of the fluid dosing unit configured to withdraw fluid from a container connected to the fluid dosing unit, the valve being configured to fluidly close the fluid line without a container connected to the fluid dosing unit, and the valve being further configured to be openable when a container is connected to the fluid dosing unit to allow withdrawal of fluid from the container through the valve, wherein the valve comprises a valve body comprising a recess for receiving a fluid permeable actor of a container according to one of claims 1 to 4.
6. The fluid dosing unit of claim 5, wherein the fluid dosing unit is a fluid dosing unit of a blood processing device.
7. A fluid dosing unit according to claim 5 or 6, wherein the valve body is an axially movable valve body which is removable from a valve seat when a container is connected to the fluid dosing unit to allow fluid to be drawn from the container through the valve.
8. A system comprising at least one container according to one of claims 1 to 4 and at least one fluid dosing unit according to one of claims 5 to 7.
9. The system of claim 8, wherein the container is reversibly attached to the fluid dosing unit.
10. A method for connecting a container for concentrate according to one of claims 1 to 4 to a fluid dosing unit according to one of claims 5 to 7, the method comprising the steps of:
-reversibly attaching the container to the fluid dosing unit by means of an attachment element present on the container and an attachment element present on the fluid dosing unit;
-moving the fluid lines of the container and/or the fluid dosing unit relative to each other such that the fluid permeable actor in the outlet of the container opens the valve in the fluid line of the fluid dosing unit to fluidly couple the container to a blood processing device.
11. The method of claim 10, wherein the fluid lines of the container and/or the fluid dosing unit are moved relative to each other such that the fluid permeable applicator is inserted into the fluid lines to move an axially movable valve body away from a valve seat to fluidly couple the container to the fluid dosing unit.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910866970.2A CN112472894B (en) | 2019-09-12 | 2019-09-12 | System and method for leak-free connection of a concentrate container to a blood processing device |
| TW109130955A TW202128234A (en) | 2019-09-12 | 2020-09-09 | System and method for connecting a concentrate container with a blood treatment device without leakages |
| CN202080064125.4A CN114390931A (en) | 2019-09-12 | 2020-09-10 | System and method for leak-free connection of a concentrate container to a blood treatment device |
| US17/642,268 US12186463B2 (en) | 2019-09-12 | 2020-09-10 | System and method for connecting a concentrate container with a blood treatment device without leakages |
| EP20768047.1A EP4028074A1 (en) | 2019-09-12 | 2020-09-10 | System and method for connecting a concentrate container with a blood treatment device without leakages |
| BR112022004498A BR112022004498A2 (en) | 2019-09-12 | 2020-09-10 | System and method for connecting a concentrate container to a leak-free blood treatment device |
| PCT/EP2020/075375 WO2021048298A1 (en) | 2019-09-12 | 2020-09-10 | System and method for connecting a concentrate container with a blood treatment device without leakages |
| KR1020227012031A KR20220062073A (en) | 2019-09-12 | 2020-09-10 | Systems and methods for leak-free connecting concentrate containers to blood treatment devices |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910866970.2A CN112472894B (en) | 2019-09-12 | 2019-09-12 | System and method for leak-free connection of a concentrate container to a blood processing device |
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| Publication Number | Publication Date |
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| CN112472894A CN112472894A (en) | 2021-03-12 |
| CN112472894B true CN112472894B (en) | 2024-07-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910866970.2A Active CN112472894B (en) | 2019-09-12 | 2019-09-12 | System and method for leak-free connection of a concentrate container to a blood processing device |
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| Country | Link |
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| CN (1) | CN112472894B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5540265A (en) * | 1992-06-26 | 1996-07-30 | Fresenius Ag | Container for collection of concentrate |
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| ES2137958T3 (en) * | 1992-06-26 | 2000-01-01 | Fresenius Medical Care De Gmbh | CONCENTRATE BAG. |
| US5806831A (en) * | 1993-10-13 | 1998-09-15 | Paradis; Joseph R. | Control of fluid flow with internal cannula |
| CN100571810C (en) * | 2004-05-11 | 2009-12-23 | 医疗器械创新有限公司 | The check valve that utilizes fluid pressure to open and close |
| EP2537772A1 (en) * | 2011-06-21 | 2012-12-26 | Weibel CDS AG | Device for holding and dispensing a fluid |
| DE102012005189A1 (en) * | 2012-03-16 | 2013-09-19 | Fresenius Medical Care Deutschland Gmbh | Medical device with a socket unit for connecting a device for providing medical fluids |
| WO2016030147A1 (en) * | 2014-08-29 | 2016-03-03 | Fresenius Kabi Deutschland Gmbh | A blood processing apparatus comprising a holder device for a measurement device |
| DE202015003656U1 (en) * | 2015-05-21 | 2015-06-23 | Ritter Gmbh | Dialysis concentrate container |
| DE102018104457A1 (en) * | 2018-02-27 | 2019-08-29 | B. Braun Avitum Ag | Connection unit for a blood treatment machine for connecting the blood treatment machine to an external container and blood treatment machine with such a connection unit |
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2019
- 2019-09-12 CN CN201910866970.2A patent/CN112472894B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5540265A (en) * | 1992-06-26 | 1996-07-30 | Fresenius Ag | Container for collection of concentrate |
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| CN112472894A (en) | 2021-03-12 |
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