CN112407429B - Pre-filling equipment for sterile solid medicine granules - Google Patents
Pre-filling equipment for sterile solid medicine granules Download PDFInfo
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- CN112407429B CN112407429B CN202011472812.8A CN202011472812A CN112407429B CN 112407429 B CN112407429 B CN 112407429B CN 202011472812 A CN202011472812 A CN 202011472812A CN 112407429 B CN112407429 B CN 112407429B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B37/00—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
- B65B37/04—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged by vibratory feeders
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B37/00—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
- B65B37/16—Separating measured quantities from supply
- B65B37/18—Separating measured quantities from supply by weighing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B43/00—Forming, feeding, opening or setting-up containers or receptacles in association with packaging
- B65B43/42—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation
- B65B43/50—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation using rotary tables or turrets
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
- B65B5/04—Packaging single articles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B57/00—Automatic control, checking, warning, or safety devices
- B65B57/10—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged
- B65B57/14—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged and operating to control, or stop, the feed of articles or material to be packaged
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B1/00—Closing bottles, jars or similar containers by applying stoppers
- B67B1/005—Feeding stoppers
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Basic Packing Technique (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses a pre-filling device of sterile solid medicine granules, which relates to the field of automation devices and comprises a workbench, a feeding vibration disc, a medicine granule dispersing mechanism, a weighing mechanism, a rubber plug press-loading mechanism and a bottle body press-loading mechanism.
Description
Technical Field
The invention belongs to the field of automation equipment, and particularly relates to a pre-filling device for sterile solid medicine granules.
Background
The preparation such as implant, liposome, microsphere and the like is a new preparation type, has long-acting slow release effect, is generally used for cavity, tissue or subcutaneous implantation, belongs to a sterile solid controlled release preparation form, and is a controlled release system which can be implanted through operation or introduced through a needle. The traditional administration modes comprise oral administration, circulatory administration, mucosal administration and the like, and have various disadvantages, such as first-pass elimination effect of oral administration, hemolytic effect of circulatory administration, incomplete absorption of mucosal administration and the like. The implanted administration mode overcomes the defects of the traditional administration mode, and the medicine directly acts on the focus part, thereby reducing the adverse reaction and greatly improving the bioavailability. In recent years, solid controlled release preparations have attracted much attention and have been studied intensively in the treatment of tumors, ocular diseases, cardiovascular diseases, and the like.
The pre-filling technology is an aseptic production process commonly used for the current aseptic preparation, the pre-filling technology for the liquid preparation is mature at present, but for novel aseptic solid preparations such as implant, liposome, microsphere and the like, no matched pre-filling equipment for solid medicine granules is provided at present, and a manual filling mode is mostly adopted, namely, the weighed solid medicine granules are firstly filled into a pre-filling needle tube by a person, a rubber plug is pressed at one end of the pre-filling needle tube and then pressed into a penicillin bottle together with the rubber plug.
Disclosure of Invention
The invention aims to provide a pre-filling device of sterile solid medicine granules (containing implants, liposomes, microspheres and the like) so as to solve the defects caused in the prior art.
The pre-filling equipment for sterile solid medicine particles comprises a workbench, a feeding vibration disc, a medicine particle dispersing mechanism, a weighing mechanism, a rubber plug press-loading mechanism and a bottle body press-loading mechanism, wherein the weighing mechanism, the rubber plug press-loading mechanism and the bottle body press-loading mechanism are sequentially arranged along the length direction of the workbench;
the feeding vibration disc is arranged on a workbench on one side of the weighing mechanism and is used for feeding the medicine particles, and the medicine particles are discharged into the medicine particle tray after the static electricity on the surface of the medicine particles is removed by the medicine particle dispersing mechanism on one side of the feeding vibration disc;
the weighing mechanism is used for weighing the weight of the empty pre-filled needle tube and the pre-filled needle tube filled with the medicine particles;
the rubber plug press-fitting mechanism is used for assembling the pre-filled needle tube filled with the medicine particles and the rubber plug together;
the bottle body press-fitting mechanism is used for press-fitting the pre-filled needle tube with the rubber plug into the bottle body and rotating to a discharging station along with the bottle body press-fitting mechanism.
Preferably, the weighing mechanism includes rotary die one, weigher and servo motor one, last a plurality of mounting grooves one that are circumference and arrange that are equipped with of rotary die, the weigher is installed in mounting groove one, the shape of the weighing pan of weigher cooperatees with the plane shape of mounting groove one, and the upper end of weighing pan is equipped with the standing groove with pre-charge needle tubing matched with, and rotary die one rotates and connects on the workstation and drives its rotation with the help of servo motor one.
Preferably, the rubber plug press-fitting mechanism comprises a second rotary die, a second servo motor, a guide mechanism and a first press-fitting assembly, a plurality of mounting grooves II which are arranged in the circumferential direction are formed in the second rotary die, the second rotary die is rotatably connected to the workbench and is driven to rotate by the second servo motor, the guide mechanism comprises a guide frame and a guide pipe, the guide frame is mounted on the workbench, the guide pipe is mounted at the other end of the guide frame and is vertically placed, the guide pipe is located right above one of the second mounting grooves, and the first press-fitting assembly is mounted right above the guide pipe and is used for achieving press-fitting of the pre-filled needle tube and the rubber plug.
Preferably, the bottle body press-fitting mechanism comprises a third rotary die, a third servo motor, a bottle body fixing mechanism, a righting mechanism and a second press-fitting assembly, the third rotary die is provided with a plurality of press-fitting holes which are arranged circumferentially, the third rotary die is rotationally connected to the workbench and is driven to rotate by the third servo motor, the third rotary die is positioned above the second rotary die, each press-fitting hole corresponds to one bottle body fixing mechanism, the bottle body fixing mechanism is used for fixing the bottle body and can take up the rubber plug together after the bottle body is pressed and assembled so that the rubber plug is separated from the rubber plug pressing and assembling mechanism, the second press-fitting assembly is arranged right above the intersection of the mounting hole and the mounting groove and used for press-fitting a pre-filled needle tube with a rubber plug into the bottle body and rotating to a discharging station along with the bottle body press-fitting mechanism, and the righting mechanism is used for pushing the rubber plug to a press-fitting position before the bottle body is press-fitted.
Preferably, the bottle fixing mechanism comprises a guide seat, two guide rods and a reset spring, the guide seat is provided with placing holes for fixing the bottle, the two guide rods are symmetrically arranged on two sides of the mounting hole and are in sliding connection with the guide seat, and the reset spring is sleeved on the guide rods and is positioned between the guide seat and the rotary mold III.
Preferably, the righting mechanism is located under the mounting hole, and specifically includes a support and a guide wheel, the one end of support is installed in the lower extreme of rotary die, and its other end rotates and is connected with the guide wheel, the bottom of guide wheel is connected with columniform lens, still installs laser marking head on the workstation that is located lens one side.
Preferably, the first press-fitting assembly and the second press-fitting assembly are identical in structure and comprise a rack, an air cylinder and a pressing plate, the rack is mounted on the workbench, the air cylinder is mounted at the upper end of the rack, and the output end of the air cylinder is connected to the pressing plate.
Preferably, the medicine granule dispersion mechanism includes support frame and static eliminator, the support frame is installed on the workstation and is located the one side of material loading vibration dish, static eliminator is installed in the upper end of support frame and is located the discharge passage top of material loading vibration dish.
The invention has the advantages that:
(1) based on assembly line type filling and automatic weighing, compared with the traditional manual filling, the invention obviously improves the filling efficiency and the weighing precision, reduces the operation error, and in the whole filling process, sterile solid medicine particles can keep good contact with the pre-filling needle tube and are not easy to spill;
(2) the weighing device can acquire the weight of the articles on the weighing device and transmit the weight to the computer, and then the computer judges whether the prefilled needle tube filled with sterile solid medicine particles meets the requirements or not, so that the consistency of the weight of the medicines in each product is ensured;
(3) the rubber plug press-fitting structure can quickly realize the pre-positioning of the pre-filled needle tube and the press-fitting with the rubber plug, so that the press-fitting efficiency is improved;
(4) the bottle body press-fitting mechanism can quickly press-fit a pre-filled needle tube with a rubber plug into a bottle body, and the rubber plug can be taken up together by the bottle body fixing mechanism after the bottle body is pressed and fitted, so that the rubber plug is separated from the rubber plug press-fitting mechanism, and the rubber plug can be pushed to a press-fitting position by the centering mechanism before the bottle body is pressed and fitted, so that the press-fitting position is correct.
Drawings
Fig. 1 and fig. 2 are schematic structural diagrams of different viewing angles according to the present invention.
FIG. 3 is a front view of the present invention with the apron below the table removed.
Fig. 4 is a schematic structural view of a weighing mechanism in the present invention.
Fig. 5 is a schematic structural view of the rubber plug press-fitting mechanism in the present invention.
FIG. 6 is a schematic view showing the structure of the bottle body press-fitting mechanism of the present invention.
Fig. 7 is a schematic view of the operation of the centering mechanism of the present invention.
Fig. 8(a) is a schematic structural view of the centering mechanism of the present invention.
Fig. 8(b) is a side view of the centering mechanism of the present invention.
Fig. 9 is a schematic structural view of a dispersion mechanism for granules of a traditional Chinese medicine according to the present invention.
Fig. 10 is an exploded view of the product of the present invention.
Wherein, 1-workbench, 2-feeding vibrating disk, 3-granule dispersing mechanism, 31-supporting frame, 32-electrostatic eliminator, 4-weighing mechanism, 41-rotary die I, 42-weighing device, 421-weighing disk, 422-placing groove, 43-servo motor I, 44-mounting groove I, 5-rubber plug press-mounting mechanism, 51-rotary die II, 52-servo motor II, 53-guiding mechanism, 531-guiding frame, 532-guiding tube, 54-mounting groove II, 55-press-mounting assembly I, 56-press-mounting assembly II, 6-bottle press-mounting mechanism, 61-rotary die III, 62-servo motor III, 63-bottle fixing mechanism, 631-guiding seat, 632-guiding rod, 633-reset spring, 634-placing hole, 64-righting mechanism, 641-bracket, 642-guide wheel, 643-lens, 644-laser marking head, 65-mounting hole, 7-medicine granule tray, 8-finished product tray;
100-prefilled needle tube, 101-plastic sleeve, 102-rubber plug and 103-bottle body.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
As shown in fig. 1 to 10, a pre-filling device for sterile solid medicine particles comprises a workbench 1, a feeding vibration tray 2, a medicine particle dispersing mechanism 3, a weighing mechanism 4, a rubber plug press-loading mechanism 5 and a bottle body press-loading mechanism 6, wherein the weighing mechanism 4, the rubber plug press-loading mechanism 5 and the bottle body press-loading mechanism 6 are sequentially arranged along the length direction of the workbench 1;
the feeding vibration disc 2 is arranged on the workbench 1 on one side of the weighing mechanism 4 and is used for feeding the medicine particles, and the medicine particles are discharged into a medicine particle tray 7 after the static electricity on the surface of the medicine particles is removed by the medicine particle dispersing mechanism 3 on one side of the feeding vibration disc 2;
the weighing mechanism 4 is used for weighing the weight of empty pre-filled needle tubes and pre-filled needle tubes filled with medicine particles, the pre-filled needle tubes comprise a plurality of pre-filled needle tubes 100 and a plastic sleeve 101, the pre-filled needle tubes 100 are integrated and then inserted into the plastic sleeve 101, and the plastic sleeve 101 is used for binding the pre-filled needle tubes 100 together in advance, so that later-stage feeding and assembling are facilitated;
the rubber plug press-fitting mechanism 5 is used for assembling the pre-filled needle tube filled with the medicine particles and the rubber plug 102 together;
the bottle body press-fitting mechanism 6 is used for press-fitting the pre-filled needle tube with the rubber plug 102 into the bottle body 103 and rotating to a blanking station along with the bottle body press-fitting mechanism 6.
In this embodiment, the weighing mechanism 4 includes a first rotary mold 41, a first scale 42 and a first servo motor 43, the first rotary mold is provided with a plurality of first mounting grooves 44 arranged circumferentially, the first scale 42 is mounted in the first mounting grooves 44, the scale disc 421 of the first scale 42 is matched in shape with the first mounting grooves 44 in plan shape, the upper end of the scale disc 421 is provided with a placing groove 422 matched with the prefilled needle tube, and the first rotary mold 41 is rotatably connected to the workbench 1 and is driven to rotate by the first servo motor 43. Each scale 42 has its own power supply and is connected to a wireless transceiver module for wirelessly transmitting the measurement data to a background computer.
In this embodiment, the rubber plug press-fitting mechanism 5 includes a second rotary die 51, a second servo motor 52, a guide mechanism 53 and a first press-fitting assembly 55, the second rotary die 51 is provided with a second plurality of circumferentially arranged mounting grooves 54, the second rotary die 51 is rotatably connected to the workbench 1 and is driven to rotate by the second servo motor 52, the guide mechanism 53 includes a guide frame 531 and a guide pipe 532, the guide frame 531 is mounted on the workbench 1, the guide pipe 532 is mounted at the other end of the guide frame 531 and is vertically disposed, the guide pipe 532 is located right above one of the second mounting grooves 54, and the first press-fitting assembly 55 is mounted right above the guide pipe 532 and is used for press-fitting the pre-filled needle tube and the rubber plug 102.
In this embodiment, the bottle body press-fitting mechanism 6 includes a third rotary die 61, a third servo motor 62, a third bottle body fixing mechanism 63, a centering mechanism 64, and a second press-fitting assembly 56, where the third rotary die 61 is provided with a plurality of press-fitting holes arranged circumferentially, the third rotary die 61 is rotatably connected to the worktable 1 and is driven to rotate by the third servo motor 62, the third rotary die 61 is located above the second rotary die 51, each press-fitting hole corresponds to one bottle body fixing mechanism 63, the bottle body fixing mechanisms 63 are used for fixing the bottle body 103 and can bring the rubber plug 102 together after the press-fitting of the bottle body 103 is finished so that the rubber plug 102 is separated from the rubber plug press-fitting mechanism 5, the second press-fitting assembly 56 is installed right above the intersection of the installation hole 65 and the installation groove and is used for press-fitting the pre-filled needle tube with the rubber plug 102 into the bottle body 103 and rotates to the blanking station along with the press-fitting mechanism 6, the centralizing mechanism 64 is used for pushing the rubber plug 102 to the press-fitting position before the bottle body 103 is press-fitted.
In this embodiment, the bottle fixing mechanism 63 includes a guide seat 631, two guide bars 632 and a return spring 633, the guide seat 631 is provided with a placing hole 634 for fixing the bottle 103, the two guide bars 632 are symmetrically disposed on two sides of the mounting hole 65, the guide bars 632 are slidably connected with the guide seat 631, and the return spring 633 is sleeved on the guide bars 632 and located between the guide seat 631 and the third rotary mold 61.
In this embodiment, the righting mechanism 64 is located right below the mounting hole 65, and specifically includes a bracket 641 and a guide wheel 642, one end of the bracket 641 is mounted at the lower end of the rotary mold, and the other end of the bracket 641 is rotatably connected with the guide wheel 642, in view of the need to laser mark a product after pressing the prefilled syringe with the rubber plug 102 onto the bottle 103, in this embodiment, marking is performed on the side surface of the rubber plug 102, so a cylindrical lens 643 is connected to the bottom of the guide wheel 642, a laser marking head 644 is further mounted on the table 1 located on one side of the lens, a connecting line between the center of the rubber plug 102 and the center of the lens 644 is parallel to a laser emitted by the laser marking head 644, and both the guide wheel 642 and the lens 643 play a role of righting, so that while righting, a laser emitted by the laser marking head 644 can be used to mark the side surface of the rubber plug 102 through the lens 643, and the product needs to be repositioned in the later period of time marking is avoided.
In this embodiment, the first press-fitting assembly 55 and the second press-fitting assembly 56 have the same structure and comprise a rack, an air cylinder and a pressing plate, the rack is mounted on the workbench 1, the air cylinder is mounted at the upper end of the rack, and the output end of the air cylinder is connected to the pressing plate.
In this embodiment, the tablet dispersing mechanism 3 includes a support frame 31 and an electrostatic eliminator 32, the support frame 31 is installed on the worktable 1 and is located at one side of the feeding vibration disk 2, and the electrostatic eliminator 32 is installed at the upper end of the support frame 31 and is located above the discharge passage of the feeding vibration disk 2.
The working process of the invention is as follows:
step one, one end of a plastic sleeve 101 of a pre-filled needle tube is placed downwards on a weighing device 42 on a rotary mold I41, the weighing device 42 obtains a weight and counts the weight into a computer, sterile solid medicine particles in a feeding vibration disc 2 are continuously discharged into a medicine particle tray 7 after static electricity is removed through a static electricity eliminator 32, a certain amount of sterile solid medicine particles are loaded into the pre-filled needle tube on one side of the pre-filled needle tube through a feeding mechanical arm (not shown in the figure), the weighing device 42 obtains a weight again, the difference value of the front weight and the rear weight is the weight of the sterile solid medicine particles, whether the weight meets a specified range is judged through the computer, and if not, the pre-filled needle tube is removed from the rotary mold I41 through a removing mechanical arm (not shown in the figure);
secondly, the pre-charging needle tubes enter a rubber plug 102 press-fitting station by virtue of the rotation of the first rotary die 41, the pre-charging needle tubes are taken down from the first rotary die 41 by a material taking manipulator and are placed into the guide tube 532 for temporary positioning, then 55 types of air cylinders of the first press-fitting assembly extend out, and the pressing plate moves downwards and presses the pre-charging needle tubes onto the rubber plug 102 in the second mounting groove 54;
step three, the pressed product continuously rotates on the second rotary die 51 to the pressing station of the bottle body 103, after the product reaches a preset position, the guide wheel 642 centralizes the rubber plug 102, and meanwhile, the laser marking head 644 is started and marks are marked on the side face of the rubber plug 102; at the moment, the bottle body 103 to be pressed is positioned right above the pre-charging needle tube, the air cylinder in the pressing assembly II 56 extends out, the pressing plate moves downwards and presses the pre-charging needle tube with the rubber plug 102 into the bottle body 103, then the air cylinder resets, the pressed product rises to the highest point under the action of the reset spring 633, the rubber plug 102 is taken up and separated from the rotary die II 51, then the rotary die III 61 continues to rotate, the pressed product rotates to a blanking station, and the pressed product is taken down by a worker or a manipulator and is placed into a corresponding finished product tray 8; in the process, when the rubber plug 102 enters the press-fitting station, the guide wheel 642 also arrives at the press-fitting station, and under the action of the guide wheel 642, the rubber plug 102 is pushed to the innermost end of the second mounting groove 54, so that the press-fitting position is ensured to be correct.
In the present invention, the rotating directions of the first rotating die 41, the second rotating die 51, and the third rotating die 61 are counterclockwise, and clockwise in sequence as viewed from above.
It will be appreciated by those skilled in the art that the invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The embodiments disclosed above are therefore to be considered in all respects as illustrative and not restrictive. All changes which come within the scope of or equivalence to the invention are intended to be embraced therein.
Claims (4)
1. The pre-filling equipment for sterile solid medicine particles is characterized by comprising a workbench (1), a feeding vibration disc (2), a medicine particle dispersing mechanism (3), a weighing mechanism (4), a rubber plug press-mounting mechanism (5) and a bottle body press-mounting mechanism (6), wherein the weighing mechanism (4), the rubber plug press-mounting mechanism (5) and the bottle body press-mounting mechanism (6) are sequentially arranged along the length direction of the workbench (1);
the feeding vibration disc (2) is arranged on the workbench (1) on one side of the weighing mechanism (4) and is used for feeding the medicine particles, and the medicine particles are discharged into the medicine particle tray (7) after static electricity on the surfaces of the medicine particles is removed by the medicine particle dispersing mechanism (3) on one side of the feeding vibration disc (2);
the weighing mechanism (4) is used for weighing the weight of the empty pre-filled needle tube and the pre-filled needle tube filled with the medicine particles;
the rubber plug press-fitting mechanism (5) is used for assembling the pre-filled needle tube filled with the medicine particles and the rubber plug (102) together;
the bottle body press-fitting mechanism (6) is used for press-fitting the pre-filled needle tube with the rubber plug (102) into the bottle body (103) and rotating to a discharging station along with the bottle body press-fitting mechanism (6);
the rubber plug press-fitting mechanism (5) comprises a second rotary die (51), a second servo motor (52), a guide mechanism (53) and a first press-fitting component (55), wherein a plurality of second mounting grooves (54) which are circumferentially arranged are formed in the second rotary die (51), the second rotary die (51) is rotatably connected to the workbench (1) and is driven to rotate by the second servo motor (52), the guide mechanism (53) comprises a guide frame (531) and a guide pipe (532), the guide frame (531) is mounted on the workbench (1), the guide pipe (532) is mounted at the other end of the guide frame (531) and is vertically placed, the guide pipe (532) is located right above one of the second mounting grooves (54), and the first press-fitting component (55) is mounted right above the guide pipe (532) and used for press-fitting the pre-filled needle tube and the rubber plug (102);
the weighing mechanism (4) comprises a first rotary die (41), a weighing device (42) and a first servo motor (43), a plurality of first mounting grooves (44) which are circumferentially arranged are formed in the rotary die, the weighing device (42) is mounted in the first mounting grooves (44), a weighing disc (421) of the weighing device (42) is matched with the planar shape of the first mounting grooves (44), a placing groove (422) matched with the needle tube in a pre-filling mode is formed in the upper end of the weighing disc (421), and the first rotary die (41) is rotationally connected to the workbench (1) and driven to rotate by means of the first servo motor (43);
the bottle press-fitting mechanism (6) comprises a rotary die III (61), a servo motor III (62), a bottle fixing mechanism (63), a centering mechanism (64) and a press-fitting assembly II (56), wherein a plurality of press-fitting holes which are circumferentially arranged are formed in the rotary die III (61), the rotary die III (61) is rotatably connected to the workbench (1) and is driven to rotate by the servo motor III (62), the rotary die III (61) is located above the rotary die II (51), each press-fitting hole corresponds to one bottle fixing mechanism (63), the bottle fixing mechanisms (63) are used for fixing the bottle bodies (103) and can drive the rubber plugs (102) to be separated from the rubber plug press-fitting mechanism (5) together after the bottle bodies (103) are pressed and fitted, the press-fitting assembly II (56) is installed right above the intersection of the mounting holes (65) and the mounting grooves and is used for press-fitting the pre-filled needle tubes with the rubber plugs (102) into the bottle bodies (103) along with the press-fitting mechanism (6) The bottle body (103) is rotated to a blanking station, and the righting mechanism (64) is used for pushing the rubber plug (102) to a press-fitting position before the bottle body (103) is pressed;
the righting mechanism (64) is located under the installation hole (65), and specifically comprises a support (641) and a guide wheel (642), one end of the support (641) is installed at the lower end of the rotary die, the other end of the support is connected with the guide wheel (642) in a rotating mode, the bottom of the guide wheel (642) is connected with a cylindrical lens (643), and a laser marking head (644) is further installed on the workbench (1) located on one side of the lens.
2. A pre-filling apparatus for sterile solid pharmaceutical pellets according to claim 1, wherein: bottle fixed establishment (63) is including guide seat (631), guide bar (632) and reset spring (633), be equipped with on guide seat (631) and be used for fixed bottle (103) place hole (634), guide bar (632) have two and the symmetry set up in the both sides of mounting hole (65), guide bar (632) and guide seat (631) sliding connection, reset spring (633) cover is located on guide bar (632) and is located between guide seat (631) and the rotational mould three (61).
3. A pre-filling apparatus for sterile solid pharmaceutical pellets according to claim 1, wherein: the press mounting assembly I (55) and the press mounting assembly II (56) are identical in structure and comprise a rack, an air cylinder and a pressing plate, the rack is mounted on the workbench (1), the air cylinder is mounted at the upper end of the rack, and the output end of the air cylinder is connected to the pressing plate.
4. A pre-filling apparatus for sterile solid pharmaceutical pellets according to claim 1, wherein: medicine grain dispersion mechanism (3) are including support frame (31) and static eliminator (32), support frame (31) are installed on workstation (1) and are located the one side of material loading vibration dish (2), static eliminator (32) are installed in the upper end of support frame (31) and are located the discharge passageway top of material loading vibration dish (2).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011472812.8A CN112407429B (en) | 2020-12-15 | 2020-12-15 | Pre-filling equipment for sterile solid medicine granules |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011472812.8A CN112407429B (en) | 2020-12-15 | 2020-12-15 | Pre-filling equipment for sterile solid medicine granules |
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| CN112407429A CN112407429A (en) | 2021-02-26 |
| CN112407429B true CN112407429B (en) | 2022-03-04 |
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| CN202011472812.8A Active CN112407429B (en) | 2020-12-15 | 2020-12-15 | Pre-filling equipment for sterile solid medicine granules |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113830362A (en) * | 2021-10-29 | 2021-12-24 | 健康元海滨药业有限公司 | Vacuum packing system |
| CN114229376B (en) * | 2022-01-12 | 2023-07-07 | 达尔嘉(广州)标识设备有限公司 | Nest removing machine capable of independently collecting boxes and discs |
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| CN104773310A (en) * | 2014-01-14 | 2015-07-15 | 罗伯特·博世有限公司 | Device for metering fine-grained filling material into packaging containers |
| CN210338367U (en) * | 2020-03-12 | 2020-04-17 | 烟台融科生物科技有限公司 | Automatic weighing type food filling machine |
| CN210417038U (en) * | 2019-06-03 | 2020-04-28 | 余姚市超成机械制造有限公司 | Powder filling machine |
| CN212047963U (en) * | 2020-04-10 | 2020-12-01 | 丹娜(天津)生物科技股份有限公司 | Microsphere filling machine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2018222859A1 (en) * | 2017-05-31 | 2018-12-06 | Allegiance Corporation | Packaging machine and modular attachment for use with a packaging machine for providing modular vented opening package sealing |
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| CN201481790U (en) * | 2009-08-26 | 2010-05-26 | 安徽中人科技有限责任公司 | Packing plant for implants |
| CN104773310A (en) * | 2014-01-14 | 2015-07-15 | 罗伯特·博世有限公司 | Device for metering fine-grained filling material into packaging containers |
| CN210417038U (en) * | 2019-06-03 | 2020-04-28 | 余姚市超成机械制造有限公司 | Powder filling machine |
| CN210338367U (en) * | 2020-03-12 | 2020-04-17 | 烟台融科生物科技有限公司 | Automatic weighing type food filling machine |
| CN212047963U (en) * | 2020-04-10 | 2020-12-01 | 丹娜(天津)生物科技股份有限公司 | Microsphere filling machine |
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