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CN112394185A - Reference substance position distribution method and sample analysis system - Google Patents

Reference substance position distribution method and sample analysis system Download PDF

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Publication number
CN112394185A
CN112394185A CN201910765578.9A CN201910765578A CN112394185A CN 112394185 A CN112394185 A CN 112394185A CN 201910765578 A CN201910765578 A CN 201910765578A CN 112394185 A CN112394185 A CN 112394185A
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reference substance
test tube
information
distributed
idle
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CN112394185B (en
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邓美清
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Physics & Mathematics (AREA)
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Abstract

The invention relates to a reference substance position distribution method and a sample analysis system, and the reference substance position distribution method provided by the invention comprises the following steps: acquiring information of a preset reference substance at a position to be distributed, wherein the information of the reference substance at the position to be distributed comprises the type of the reference substance; receiving an instruction to dispense a location for a reference material for a location to be dispensed; selecting a test tube rack of a corresponding type for the reference substance at the position to be distributed according to the type of the reference substance; acquiring the occupation information of the test tube positions on the test tube rack corresponding to the type of the reference substance at the position to be distributed, wherein the occupation information comprises: occupied and idle; distributing an idle test tube position for the reference material of each position to be distributed, and establishing a corresponding relation between the reference material and the position information of the test tube position, wherein the position information comprises: test tube rack identification and test tube position number; the reference substance position distribution method provided by the invention can automatically distribute the position for the reference substance without manually distributing the position, and is simple and convenient to operate and convenient to use.

Description

Reference substance position distribution method and sample analysis system
Technical Field
The invention relates to the technical field of medical equipment, in particular to a reference substance position distribution method and a sample analysis system.
Background
The sample analysis system comprises control equipment, a sample transfer mechanism and at least one analyzer, wherein the sample transfer mechanism is used for conveying a test tube rack with test tubes, and the test tubes are internally provided with samples. Different kinds of analyzers can detect different detection items. For example, biochemical analyzers are used to detect liver function, kidney function, blood glucose and blood lipid in samples. The immunoassay analyzer is used for detecting related detection items such as antigens or antibodies.
The control equipment is used for controlling the sample transfer mechanism to transfer the sample to be detected to the corresponding analyzer, so that the detection items are automatically completed.
The results of the samples tested by the analyzer vary with the standard limit settings. Therefore, the analyzer needs to be calibrated, and a calibration test is performed by using the calibrator. In order to control the measurement error of the sample, repeated detection with a stable reference material is required, that is, a quality control test is performed using a quality control material.
When calibration or quality control is performed, a user needs to set a position for a calibration product or a quality control product on a corresponding software interface, for example, the user sets the 1 st test tube position of the calibration product 1 on the No. 1 calibration rack on the software interface. And (3) putting the calibrator 1 into the 1 st test tube position of the No. 1 calibration rack according to the set position by the user. During the test, what kind of calibrator was put to the 1 st test tube position of 1 # calibration frame can be known to the analysis appearance to carry out corresponding testing process.
When the sample analysis system is first installed, after the test items are configured, all the test items need to be calibrated and quality controlled. At this time, the user needs to set positions for a large number of calibration products and quality control products on a software interface, and the operation is complex and the use is inconvenient.
And the analyzer needs to be calibrated or quality controlled when the calibrator or quality control is changed for a batch. At this time, the user is also required to manually identify the idle position on the software interface, and then allocate and set the position for the calibration product or the quality control product, which has the disadvantages of large workload, complex operation and inconvenient use.
Disclosure of Invention
The present invention provides a reference material position distribution method and a sample analysis system capable of automatically distributing a position for a calibrator/quality controller.
To achieve the above technical problem, in one embodiment, the present invention provides a reference substance position distribution method applied to a sample analysis system including a sample transfer mechanism and a sample analyzer,
the sample transfer mechanism is used for conveying a test tube rack provided with test tubes, the test tube rack is provided with a plurality of test tube positions, each test tube position is used for placing the corresponding test tube, the test tube is used for storing an object to be tested, the object to be tested comprises a reference substance, the test tube rack is provided with a test tube rack mark, each test tube position on the test tube rack is provided with a corresponding serial number,
the sample analyzer is used for detecting corresponding items of the object to be detected,
the reference substance position distribution method comprises the following steps:
acquiring information of a preset reference substance at a position to be distributed, wherein the information of the reference substance at the position to be distributed comprises the type of the reference substance;
receiving an instruction for a reference material dispensing location for the location to be dispensed;
selecting a test tube rack of a corresponding type for the reference substance at the position to be distributed according to the type of the reference substance;
acquiring occupation information of test tube positions on the test tube rack corresponding to the type of the reference substance at the position to be distributed, wherein the occupation information comprises: occupied and idle;
distributing an idle test tube position for the reference substance of each position to be distributed, and establishing a corresponding relation between the reference substance distributed with the idle test tube position and the position information of the test tube position, wherein the position information comprises: test-tube rack sign and test tube position serial number.
In one embodiment, the type of the reference material is a quality control product or a calibration product, and the type of the test tube rack comprises a quality control rack or a calibration rack.
In one embodiment, the information of the reference substance at the to-be-dispensed position further includes a category name and a concentration parameter of the reference substance, the step of assigning an idle test tube position to the reference substance at each to-be-dispensed position, and the step of establishing a corresponding relationship between the reference substance assigned with the idle test tube position and the position information of the test tube position includes:
if the reference substances at the positions to be distributed comprise a plurality of reference substances, distributing idle test tube positions for the reference substances at the positions to be distributed in sequence according to a preset sequence; or
If the reference substances at the positions to be distributed comprise a plurality of reference substances with the same category names but different concentration parameters, idle test tube positions are sequentially distributed for the reference substances with the same category names but different concentration parameters according to the size sequence of the concentration parameters.
In one embodiment, the sequentially allocating the vacant test tube positions for the reference substances with the same category name but different concentration parameters according to the size sequence of the concentration parameters comprises: and sequentially allocating idle test tube positions with the numbers from small to large for the reference substances with the same type names but different concentration parameters according to the sequence from small to large of the concentration parameters.
In one embodiment, the reference substances at the positions to be allocated include a first reference substance and a second reference substance with the same category name, the concentration parameter of the first reference substance is a first concentration parameter, the concentration parameter of the second reference substance is a second concentration parameter, an idle test tube position is allocated to each reference substance at the positions to be allocated, and the corresponding relationship between the reference substance allocated with the idle test tube position and the position information of the test tube position is established, including:
distributing an idle first test tube position for the first reference substance, and establishing a corresponding relation between the first reference substance and the position information of the first test tube position, wherein the position information of the first test tube position comprises a first test tube rack identifier and a first test tube position number;
and distributing an idle second test tube position for the second reference substance, and establishing a corresponding relation between the second reference substance and the position information of the second test tube position, wherein the position information of the second test tube position comprises the first test tube rack identification and the second test tube position number.
In one embodiment, the information of the reference substance of the to-be-dispensed position further includes a detection item of the reference substance, the reference substance of each to-be-dispensed position is allocated with a free test tube position, and after the corresponding relationship between the reference substance allocated with the free test tube position and the position information of the test tube position is established, the method further includes:
distributing corresponding reagents for the reference substances according to the detection items of the reference substances, so that the reagents and the corresponding reference substances at the positions to be distributed are uniformly mixed to carry out detection of the corresponding items, and establishing the corresponding relation between the reference substances at the positions to be distributed and the identifications of the reagents.
In one embodiment, after the reference material at each of the positions to be allocated is allocated with an idle test tube position, and the corresponding relationship between the reference material allocated with the idle test tube position and the position information of the test tube position is established, the method further includes:
receiving an application calibration command;
generating test information of the reference substance according to the application calibration command, wherein the test information comprises information of the reference substance, position information of a tube position allocated to the reference substance and identification of a reagent allocated to the reference substance;
receiving a test starting command;
selecting a target sample analyzer from the sample analyzers according to the detection items of the reference substance;
controlling the sample transfer mechanism to convey the reference substance on the corresponding test tube position to the target sample analyzer according to the position information;
controlling the target sample analyzer to collect the reference substance;
and controlling the target sample analyzer to uniformly mix the collected reference substance with the corresponding reagent and detect corresponding items.
In one embodiment, before the obtaining of the information of the reference substance at the preset to-be-dispensed position, the method further comprises:
receiving an instruction to add the reference substance;
receiving user-input information of the added reference substance; the added reference substance is the reference substance of the location to be dispensed.
In one embodiment, before the receiving the instruction to increase the reference substance, the method further comprises:
and providing a setting interface of the reference substance, wherein a button for adding the reference substance and information for displaying the added reference substance are displayed on the setting interface, and the button for adding the reference substance is used for receiving the instruction for adding the reference substance.
In one embodiment, an automatic dispensing position button is further provided on the setting interface for receiving the instruction of the dispensing position for the reference substance of the to-be-dispensed position.
In one embodiment, the present invention also provides a sample analysis system comprising a sample transfer mechanism, a sample analyzer, and a data management device,
the sample transfer mechanism is used for conveying a test tube rack provided with test tubes, the test tube rack is provided with a plurality of test tube positions, each test tube position is used for placing the corresponding test tube, the test tube is used for storing an object to be tested, the object to be tested comprises a reference substance, the test tube rack is provided with a test tube rack mark, each test tube position on the test tube rack is provided with a corresponding serial number,
the sample analyzer is used for detecting corresponding items of the object to be detected,
the data management device is connected with the sample transfer mechanism and the sample analyzer respectively, and is used for:
acquiring information of a preset reference substance at a position to be distributed, wherein the information of the reference substance at the position to be distributed comprises the type of the reference substance;
receiving an instruction for a reference material dispensing location for the location to be dispensed;
selecting a test tube rack of a corresponding type for the reference substance at the position to be distributed according to the type of the reference substance;
acquiring occupation information of test tube positions on the test tube rack corresponding to the type of the reference substance at the position to be distributed, wherein the occupation information comprises: occupied and idle;
distributing an idle test tube position for the reference substance of each position to be distributed, and establishing a corresponding relation between the reference substance distributed with the idle test tube position and the position information of the test tube position, wherein the position information comprises: test-tube rack sign and test tube position serial number.
In one embodiment, the information of the reference substance at the position to be dispensed further includes a category name and a concentration parameter of the reference substance, and the data management device is further configured to:
if the reference substances at the positions to be distributed comprise a plurality of reference substances, distributing idle test tube positions for the reference substances at the positions to be distributed in sequence according to a preset sequence; or
If the reference substances at the positions to be distributed comprise a plurality of reference substances with the same category names but different concentration parameters, idle test tube positions are sequentially distributed for the reference substances with the same category names but different concentration parameters according to the size sequence of the concentration parameters.
In one embodiment, the data management apparatus is further configured to:
and sequentially allocating idle test tube positions with the numbers from small to large for the reference substances with the same type names but different concentration parameters according to the sequence from small to large of the concentration parameters.
In one embodiment, the reference substance of the to-be-dispensed position includes a first reference substance and a second reference substance having the same category name, the concentration parameter of the first reference substance is a first concentration parameter, the concentration parameter of the second reference substance is a second concentration parameter, and the data management apparatus is further configured to:
distributing an idle first test tube position for the first reference substance, and establishing a corresponding relation between the first reference substance and the position information of the first test tube position, wherein the position information of the first test tube position comprises a first test tube rack identifier and a first test tube position number;
and distributing an idle second test tube position for the second reference substance, and establishing a corresponding relation between the second reference substance and the position information of the second test tube position, wherein the position information of the second test tube position comprises the first test tube rack identification and the second test tube position number.
In one embodiment, the information of the reference substance at the position to be dispensed further includes a detection item of the reference substance, and the data management device is further configured to:
distributing corresponding reagents for the reference substances according to the detection items of the reference substances, so that the reagents and the corresponding reference substances at the positions to be distributed are uniformly mixed to carry out detection of the corresponding items, and establishing the corresponding relation between the reference substances at the positions to be distributed and the identifications of the reagents.
In one embodiment, the data management apparatus is further configured to:
receiving an application calibration command;
generating test information of the reference substance according to the application calibration command, wherein the test information comprises information of the reference substance, position information of a tube position allocated to the reference substance and identification of a reagent allocated to the reference substance;
receiving a test starting command;
selecting a target sample analyzer from the sample analyzers according to the detection items of the reference substance;
controlling the sample transfer mechanism to convey the reference substance on the corresponding test tube position to the target sample analyzer according to the position information;
controlling the target sample analyzer to collect the reference substance;
and controlling the target sample analyzer to uniformly mix the collected reference substance with the corresponding reagent and detect corresponding items.
In one embodiment, the data management apparatus is further configured to:
receiving an instruction to add the reference substance;
receiving user-input information of the added reference substance; the added reference substance is the reference substance of the location to be dispensed.
In one embodiment, the data management apparatus is further configured to:
and providing a setting interface of the reference substance, wherein a button for adding the reference substance and information for displaying the added reference substance are displayed on the setting interface, and the button for adding the reference substance is used for receiving the instruction for adding the reference substance.
The invention has the beneficial effects that:
the invention provides a reference substance position distribution method, which comprises the following steps: acquiring information of a preset reference substance at a position to be distributed, wherein the information of the reference substance at the position to be distributed comprises the type of the reference substance; receiving an instruction to dispense a location for a reference material for a location to be dispensed; selecting a test tube rack of a corresponding type for the reference substance at the position to be distributed according to the type of the reference substance; acquiring the occupation information of the test tube positions on the test tube rack corresponding to the type of the reference substance at the position to be distributed, wherein the occupation information comprises: occupied and idle; distributing idle test tube positions for the reference materials of each position to be distributed, and establishing the corresponding relation between the reference materials distributed with the idle test tube positions and the position information of the test tube positions, wherein the position information comprises: test tube rack identification and test tube position number; the reference substance position distribution method provided by the invention can automatically distribute the position for the reference substance without manually distributing the position, and is simple and convenient to operate and convenient to use.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and together with the description, serve to explain the principles of the invention.
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without inventive exercise.
FIG. 1 is a schematic diagram of a sample analysis system according to an embodiment of the present invention;
fig. 2 is a schematic structural view of a test tube rack according to an embodiment of the present invention;
fig. 3 is a schematic structural view of a test tube rack according to an embodiment of the present invention;
FIGS. 4-12 are flow charts of a reference mass location assignment method in accordance with one embodiment of the present invention;
FIG. 13 is a schematic view of a setup interface in accordance with an embodiment of the present invention;
FIG. 14 is a diagram of a sample analysis system in accordance with an embodiment of the present invention.
Wherein, the correspondence between the reference numbers and the part names in fig. 1 to 14 is:
10. the device comprises a sample transfer mechanism, 20, a sample analyzer, 30, a test tube rack, 31, a test tube position, 40, a setting interface, 50 and a data management device.
Detailed Description
The present invention will be described in further detail with reference to the following detailed description and accompanying drawings. Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.
Furthermore, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. Also, the various steps or actions in the method descriptions may be transposed or transposed in order, as will be apparent to one of ordinary skill in the art. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.
The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings).
The terms used in this application are defined as follows:
calibration products: the calibration of test items for quantitative testing is a reference with values that are used as independent variables in a calibration function. The calibrator comprises at least one concentration level. For example, typically 1, 2 or 3 concentration levels are included. The calibrator is mostly derived from a mixture of human samples, such as pooled serum. The plant self-body contains the detected analyte, and the vegetation is added with certain analytes at any time to increase the content.
Quality control product: a biological product with a certain shelf life for checking/verifying the performance of an analyzer (quality control purpose) is generally prepared by using human or animal serum or other body fluid as a matrix and adding other additional materials.
The invention provides a reference substance position distribution method which is applied to a sample analysis system.
Fig. 1 is a schematic structural diagram of a sample analysis system according to an embodiment of the present invention. In one embodiment, as shown in fig. 1, the sample analysis system includes a sample transfer mechanism 10 and a sample analyzer 20.
The specimen transfer mechanism 10 is used for transporting a test tube rack 30 on which test tubes are placed, and the test tube rack 30 is provided with a plurality of test tube positions 31. Each test tube position 31 is used for placing a corresponding test tube, and the test tube is used for storing an object to be tested.
Be equipped with the test-tube rack sign on the test-tube rack 30, distinguish test-tube rack 30 through the test-tube rack sign, the test-tube rack sign can be the bar code, and the bar code can comprise letter and digit, for example S0001.
Fig. 2 is a schematic structural view of a test tube rack according to an embodiment of the present invention, and fig. 3 is a schematic structural view of a test tube rack according to an embodiment of the present invention. As shown in fig. 2 and 3, each test tube position 31 on the test tube rack 30 has a corresponding number, and the test tube positions 31 on the test tube rack 30 are distinguished by the numbers. For example, the test tube positions 31 arranged from left to right on the tube rack 30 may be sequentially numbered with arabic numerals, with the numbers increasing from small to large (e.g., numbers 1, 2, 3, 4 … …), or with numbers decreasing from large to small (e.g., numbers 10, 9, 8, 7 … …).
The analyte may be a body fluid to be analyzed, such as serum, plasma, urine, cerebrospinal fluid, or amniotic fluid.
In this embodiment, the analyte includes a reference substance, and the reference substance is a quality control substance or a calibration substance. As will be appreciated by those skilled in the art, the test substance may also include a common sample, which is a sample of a body fluid from a patient under clinical examination.
In the present embodiment, the number of the test tube positions 31 provided in the test tube rack 30 is 10. Those skilled in the art will appreciate that in other embodiments, the number of the test tube positions 31 provided on the test tube rack 30 may be any number, such as 7, 8, or 9, and is not limited herein.
The sample analyzer 20 is used for detecting the corresponding items of the object to be detected. The sample analysis system may include one or more types of sample analyzers 20, each type of sample analyzer 20 being used to detect a different test item. One skilled in the art will appreciate that the number of each analyzer may be one or more, and is not limited herein.
The sample transfer mechanism 10 transports the test tube rack 30 in the sample introduction direction, so that the sample analyzer 20 sequentially detects the test tube positions 31 arranged in the sample introduction direction on the test tube rack 30.
In one embodiment, the sample analysis system includes a sample analyzer 20, and the sample analyzer 20 may be a biochemical analyzer or an immunoassay analyzer. The biochemical analyzer is used for detecting various substance components in a sample, such as related parameters of liver function, kidney function, blood sugar, blood fat and the like. The immunoassay analyzer is used for detecting relevant parameters such as antigens or antibodies in a sample.
In one embodiment, the sample analysis system includes two sample analyzers 20, and the two sample analyzers 20 may be a biochemical analyzer and an immunoassay analyzer, respectively.
FIG. 4 is a flow chart of a method for dispensing a reference material location in accordance with an embodiment of the present invention. As shown in fig. 4, in one embodiment, the reference substance position distribution method specifically includes the following steps:
step S100, obtaining information of a preset reference substance at a to-be-dispensed position, where the information of the reference substance at the to-be-dispensed position includes a type of the reference substance.
Step S110, receiving an instruction to dispense a position for a reference substance to be dispensed.
Step S120, selecting a corresponding type of test tube rack 30 for the reference material at the position to be dispensed according to the type of the reference material.
Step S130, acquiring occupation information of the test tube position 31 on the test tube rack 30 corresponding to the reference material type of the position to be distributed, wherein the occupation information includes: occupied and idle.
Step S140, allocating a test tube position 31 with idle occupancy information to each reference material to be allocated, and establishing a corresponding relationship between the reference material allocated with the idle test tube position 31 and the position information of the test tube position 31, where the position information includes: test-tube rack identification and test tube position 31 serial number.
The reference substance position distribution method provided by the invention can automatically distribute the position for the reference substance without manually distributing the position, so that the manpower is saved, the operation is simple and convenient, and the use is convenient.
The information of the reference substance at the preset position to be distributed can be the existing information or the newly added information of the user.
The reference substance is a quality control substance or a calibration substance, and the quality control substance or the calibration substance is the type of the reference substance. The types of test tube racks 30 include a quality control rack or a calibration rack. If the reference substance is a quality control product, a quality control frame is distributed for the reference substance. If the reference substance is a calibration article, a calibration rack is assigned to the reference substance.
The quality control frame is specially used for quality control test, and the calibration frame is specially used for calibration test.
In other embodiments, the types of test tube racks 30 also include conventional test tube racks that are used for clinical testing. The structure of matter accuse frame or calibration frame can be the same with the structure of conventional test-tube rack, only distinguishes through the test-tube rack sign, and for example the test-tube rack sign of conventional test-tube rack is the beginning of letter N, and the test-tube rack sign of matter accuse frame is the beginning of letter C, and the test-tube rack sign of calibrator is the beginning of letter S. The structure of the quality control rack or the calibration rack may also be different from that of a conventional test tube rack, and is not limited herein.
The information of the reference substance may further include information such as a lot number of the reference substance and a term of validity of the reference substance.
FIG. 5 is a flow chart of a method for dispensing a reference material location in accordance with an embodiment of the present invention. In one embodiment, as shown in fig. 5, the information of the reference substance further includes an identifier of the reference substance, and the step S140 of establishing a corresponding relationship between the reference substance of the assigned vacant test tube site 31 and the position information of the test tube site 31 includes:
step S200, establishing the corresponding relation between the identification of the reference substance of the allocated idle test tube position 31 and the position information of the test tube position 31.
The identification of the reference substance is the identification of the reference substance and is used for distinguishing the reference substance.
FIG. 6 is a flow chart of a method for dispensing a reference material location in accordance with an embodiment of the present invention. In one embodiment, as shown in fig. 6, the information of the reference substance at the position to be dispensed further includes a category name and a concentration parameter of the reference substance. Assigning an idle test tube position 31 to each reference material of the to-be-assigned position, and establishing a corresponding relationship between the reference material assigned with the idle test tube position 31 and the position information of the test tube position 31, that is, step S140, includes:
step S300, if the reference material at the position to be distributed includes a plurality of reference materials, determining whether the type names of the plurality of reference materials are the same.
If the names of the reference materials are not the same, the process goes to step S301. If the species names of the reference substances are the same, the process goes to step S302.
Step S301, if the reference substance at the to-be-dispensed position includes a plurality of reference substances, sequentially dispensing an empty test tube position 31 for each reference substance at the to-be-dispensed position according to a preset sequence.
In step S302, if the reference substance at the position to be dispensed includes a plurality of reference substances with the same type name but different concentration parameters, the plurality of reference substances with the same type name but different concentration parameters are sequentially dispensed with the empty test tube positions 31 according to the magnitude order of the concentration parameters.
The sample analyzer 20 collects a reference substance in the test tube through the sampling needle, and then transfers the collected reference substance to the reaction cell, thereby detecting the reference substance. Furthermore, if a high-concentration reference substance is collected first, the high-concentration reference substance remaining in the sampling needle increases the concentration of a subsequently collected low-concentration reference substance, thereby affecting the detection result of the low-concentration reference substance. Further, the sample analyzer 20 detects the reference substance with low concentration first and then detects the reference substance with high concentration, so as to improve the accuracy of the detection result.
Further, when the reference substance is dispensed to the reference substance dispensing position, the reference substance of a low concentration is dispensed to the test tube position 31 on the test tube rack 30 as far as possible so that the sample analyzer 20 detects the reference substance of a low concentration first.
The front test tube position 31 is the front test tube position 31 arranged in sequence along the sample introduction direction according to the test tube rack 30. If the test tube positions 31 on the test tube rack 30 are numbered in a manner of increasing progressively from left to right, the test tube position 31 with the smallest number is the most front test tube position 31 when the sample introduction direction is to the left (for example, the test tube position 31 with the number of 1 is the most front test tube position 31); or when the sample introduction direction is rightward, the test tube position 31 with the largest number is the most forward test tube position 31 (for example, the test tube position 31 with the number of 10 is the most forward test tube position 31).
FIG. 7 is a flow chart of a method for dispensing a reference material location in accordance with an embodiment of the present invention. In one embodiment, as shown in fig. 7, sequentially allocating the vacant test tube positions 31 for a plurality of reference substances having the same category name but different concentration parameters according to the magnitude order of the concentration parameters, step 302, includes:
in step 400, according to the sequence of the concentration parameters from small to large, idle test tube positions 31 with the serial numbers from small to large are sequentially distributed to a plurality of reference substances with the same type names but different concentration parameters.
FIG. 8 is a flow chart of a method for dispensing a reference material location in accordance with an embodiment of the present invention. In one embodiment, as shown in fig. 8, the reference substance of the to-be-dispensed position includes a first reference substance and a second reference substance with the same category name, the concentration parameter of the first reference substance is a first concentration parameter, the concentration parameter of the second reference substance is a second concentration parameter, a vacant test tube position 31 is allocated to each reference substance of the to-be-dispensed position, and the corresponding relationship between the reference substance allocated with the vacant test tube position 31 and the position information of the test tube position 31 is established, that is, step S140, includes:
step S500, distributing an idle first test tube position 31 for the first reference substance, and establishing a corresponding relation between the first reference substance and the position information of the first test tube position 31, wherein the position information of the first test tube position 31 comprises a first test tube rack identifier and a first test tube position 31 number.
Step S501, distributing an idle second test tube position 31 for a second reference substance, and establishing a corresponding relation between the second reference substance and position information of the second test tube position 31, wherein the position information of the second test tube position 31 comprises a first test tube rack identifier and a second test tube position 31 number.
Wherein the identification of the first reference substance is a first identification and the identification of the second reference substance is a second identification. Establishing the correspondence between the first reference substance and the position information of the first test tube site 31 includes: the correspondence between the first identifier and the position information of the first test tube position 31 is established. Establishing the correspondence between the second reference substance and the position information of the second test tube position 31 includes: and establishing the corresponding relation between the second identifier and the position information of the second test tube position 31.
After the reference substance is collected by the sampling needle of the sample analyzer 20, the collected reference substance is transferred into the reaction cell, and then a corresponding reagent is added to detect the reference substance.
FIG. 9 is a flow chart of a method for dispensing a reference material location in accordance with an embodiment of the present invention. In one embodiment, as shown in fig. 9, the information of the reference substance of the position to be dispensed further includes a detection item of the reference substance. After the idle test tube position 31 is allocated to the reference material of each to-be-allocated position, and the corresponding relationship between the reference material allocated to the idle test tube position 31 and the position information of the test tube position 31 is established, that is, after step S140, the method further includes:
step 600, distributing a corresponding reagent for the reference substance according to the detection item of the reference substance, so that the reagent is uniformly mixed with the reference substance at the corresponding position to be distributed to perform detection of the corresponding item, and establishing a corresponding relation between the reference substance at the position to be distributed and the identifier of the reagent.
Wherein, the identification of the reagent is the identification of the reagent and is used for distinguishing the reagent.
FIG. 10 is a flow chart of a method for dispensing a reference material location in accordance with an embodiment of the present invention. In one embodiment, as shown in fig. 10, after allocating a free test tube position 31 to each reference material to be allocated, and establishing a corresponding relationship between the reference material allocated to the free test tube position 31 and the position information of the test tube position 31, that is, after step S140, the method further includes:
step S700, receiving an application calibration command.
Step S701, generating test information of the reference substance according to the application calibration command, where the test information includes information of the reference substance, position information of the test tube position 31 assigned to the reference substance, and an identifier of the reagent assigned to the reference substance.
Step S702, receiving a starting test command.
In step S703, the target sample analyzer 20 is selected among the sample analyzers 20 according to the detection items of the reference substance.
In step S704, the sample transfer mechanism 10 is controlled according to the position information to transfer the reference substance on the corresponding test tube position 31 to the target sample analyzer 20.
In step S705, the target sample analyzer 20 is controlled to collect the reference substance.
Step S706, controlling the target sample analyzer 20 to mix the collected reference substance with the corresponding reagent and perform the detection of the corresponding item.
Wherein after generating the test information of the reference substances according to the application calibration command, i.e. after step S701, each reference substance is placed on the corresponding test tube position 31 before receiving the start test command, i.e. before step S702.
FIG. 11 is a flow chart of a method for dispensing a reference material location in accordance with an embodiment of the present invention. In one embodiment, as shown in fig. 11, before the information of the reference substance at the preset position to be dispensed is obtained, i.e. before step S100, the method further includes:
step S800, receiving an instruction to add a reference substance.
Step S801, receiving information of an added reference substance input by a user, wherein the added reference substance is a reference substance of a position to be dispensed.
Fig. 12 is a flowchart of a reference substance position distribution method according to an embodiment of the present invention, and fig. 13 is a schematic view of a setup interface according to an embodiment of the present invention. In one embodiment, as shown in fig. 12 and 13, before receiving the instruction to add the reference substance, i.e. before step S800, the method further includes:
and step S900, providing a setting interface 40 of the reference substance, wherein the setting interface 40 is displayed with a button for adding the reference substance and information for displaying the added reference substance, and the button for adding the reference substance is used for receiving an instruction for adding the reference substance.
In one embodiment, an automatic dispense location button is also provided on the setup interface 40 for receiving instructions for a reference material dispense location for the location to be dispensed.
FIG. 14 is a diagram of a sample analysis system in accordance with an embodiment of the present invention. In one embodiment, as shown in fig. 14, the sample analysis system further includes a data management device 50, and the data management device 50 is connected to the sample transfer mechanism 10 and the sample analyzer 20, respectively.
The data management apparatus 50 is configured to:
acquiring information of a preset reference substance at a position to be distributed, wherein the information of the reference substance at the position to be distributed comprises the type of the reference substance;
receiving an instruction to dispense a location for a reference material for a location to be dispensed;
selecting a test tube rack 30 of a corresponding type for the reference material at the position to be distributed according to the type of the reference material;
acquiring occupation information of a test tube position 31 on the test tube rack 30 corresponding to the type of the reference substance at the position to be distributed, wherein the occupation information comprises: occupied and idle;
distributing an idle test tube position 31 for the reference material of each position to be distributed, and establishing the corresponding relation between the reference material distributed with the idle test tube position 31 and the position information of the test tube position 31, wherein the position information comprises: test-tube rack identification and test tube position 31 serial number.
In one embodiment, the information of the reference substance at the position to be dispensed further includes a category name and a concentration parameter of the reference substance, and the data management device 50 is further configured to:
if the reference substances at the positions to be distributed comprise a plurality of reference substances, distributing idle test tube positions 31 for the reference substances at each position to be distributed in sequence according to a preset sequence; or
If the reference substance at the position to be distributed comprises a plurality of reference substances with the same type name but different concentration parameters, the idle test tube positions 31 are sequentially distributed for the plurality of reference substances with the same type name but different concentration parameters according to the size sequence of the concentration parameters.
In one embodiment, the data management device 50 is further configured to:
according to the sequence of the concentration parameters from small to large, idle test tube positions 31 with the serial numbers from small to large are sequentially distributed to a plurality of reference substances with the same type names but different concentration parameters.
In one embodiment, the reference substances at the positions to be dispensed include a first reference substance and a second reference substance having the same category name, the concentration parameter of the first reference substance is a first concentration parameter, the concentration parameter of the second reference substance is a second concentration parameter, and the data management device 50 is further configured to:
distributing an idle first test tube position 31 for the first reference substance, and establishing a corresponding relation between the first reference substance and position information of the first test tube position 31, wherein the position information of the first test tube position 31 comprises a first test tube rack identifier and a first test tube position 31 number;
and distributing an idle second test tube position 31 for the second reference substance, and establishing a corresponding relation between the second reference substance and the position information of the second test tube position 31, wherein the position information of the second test tube position 31 comprises a first test tube rack identifier and a second test tube position 31 number.
In one embodiment, the information of the reference substance of the position to be dispensed further includes a detection item of the reference substance, and the data management device 50 is further configured to:
distributing corresponding reagents for the reference substances according to the detection items of the reference substances, so that the reagents are uniformly mixed with the reference substances at the corresponding positions to be distributed to carry out detection of the corresponding items, and establishing the corresponding relation between the reference substances at the positions to be distributed and the identifications of the reagents.
In one embodiment, the data management device 50 is further configured to:
receiving an application calibration command;
generating test information of the reference substance according to the application calibration command, wherein the test information comprises information of the reference substance, position information of the test tube position 31 distributed for the reference substance and identification of the reagent distributed for the reference substance;
receiving a test starting command;
selecting a target sample analyzer 20 among the sample analyzers 20 according to the detection items of the reference substances;
controlling the sample transfer mechanism 10 to transfer the reference substance on the corresponding test tube position 31 to the target sample analyzer 20 according to the position information;
controlling the target sample analyzer 20 to collect the reference substance;
and controlling the target sample analyzer 20 to uniformly mix the collected reference substance with the corresponding reagent and perform detection of the corresponding item.
In one embodiment, the data management device 50 is further configured to:
receiving an instruction to add a reference substance;
receiving user-input information of the added reference substance; the added reference substance is the reference substance of the location to be dispensed.
In one embodiment, the data management device 50 is further configured to:
a setting interface 40 for providing the reference substance, wherein the setting interface 40 is displayed with a button for adding the reference substance and information for displaying the added reference substance, and the button for adding the reference substance is used for receiving an instruction for adding the reference substance.
It is noted that, in this document, relational terms such as "first" and "second," and the like, may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The foregoing are merely exemplary embodiments of the present invention, which enable those skilled in the art to understand or practice the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (18)

1. A reference substance position distribution method is applied to a sample analysis system, the sample analysis system comprises a sample transfer mechanism and a sample analyzer,
the sample transfer mechanism is used for conveying a test tube rack provided with test tubes, the test tube rack is provided with a plurality of test tube positions, each test tube position is used for placing the corresponding test tube, the test tube is used for storing an object to be tested, the object to be tested comprises a reference substance, the test tube rack is provided with a test tube rack mark, each test tube position on the test tube rack is provided with a corresponding serial number,
the sample analyzer is used for detecting corresponding items of the object to be detected,
the reference substance position distribution method comprises the following steps:
acquiring information of a preset reference substance at a position to be distributed, wherein the information of the reference substance at the position to be distributed comprises the type of the reference substance;
receiving an instruction for a reference material dispensing location for the location to be dispensed;
selecting a test tube rack of a corresponding type for the reference substance at the position to be distributed according to the type of the reference substance;
acquiring occupation information of test tube positions on the test tube rack corresponding to the type of the reference substance at the position to be distributed, wherein the occupation information comprises: occupied and idle;
distributing an idle test tube position for the reference substance of each position to be distributed, and establishing a corresponding relation between the reference substance distributed with the idle test tube position and the position information of the test tube position, wherein the position information comprises: test-tube rack sign and test tube position serial number.
2. The reference material position distribution method according to claim 1, wherein the type of the reference material is a quality control product or a calibration product, and the type of the test tube rack includes a quality control rack or a calibration rack.
3. The reference material position distribution method according to claim 1 or 2, wherein the information of the reference material of the position to be distributed further includes a category name and a concentration parameter of the reference material, the distributing an idle test tube position for each reference material of the position to be distributed, and establishing a corresponding relationship between the reference material distributed with the idle test tube position and the position information of the test tube position includes:
if the reference substances at the positions to be distributed comprise a plurality of reference substances, distributing idle test tube positions for the reference substances at the positions to be distributed in sequence according to a preset sequence; or
If the reference substances at the positions to be distributed comprise a plurality of reference substances with the same category names but different concentration parameters, idle test tube positions are sequentially distributed for the reference substances with the same category names but different concentration parameters according to the size sequence of the concentration parameters.
4. The reference substance position distribution method according to claim 3, wherein the sequentially distributing the empty test tube positions for the plurality of reference substances having the same category name but different concentration parameters according to the magnitude order of the concentration parameters comprises: and sequentially allocating idle test tube positions with the numbers from small to large for the reference substances with the same type names but different concentration parameters according to the sequence from small to large of the concentration parameters.
5. The reference substance position distribution method according to claim 3, wherein the reference substance at the position to be distributed includes a first reference substance and a second reference substance having the same category name, the concentration parameter of the first reference substance is a first concentration parameter, the concentration parameter of the second reference substance is a second concentration parameter, the reference substance at each position to be distributed is distributed with an idle test tube position, and the corresponding relationship between the reference substance distributed with the idle test tube position and the position information of the test tube position is established, and the method includes:
distributing an idle first test tube position for the first reference substance, and establishing a corresponding relation between the first reference substance and the position information of the first test tube position, wherein the position information of the first test tube position comprises a first test tube rack identifier and a first test tube position number;
and distributing an idle second test tube position for the second reference substance, and establishing a corresponding relation between the second reference substance and the position information of the second test tube position, wherein the position information of the second test tube position comprises the first test tube rack identification and the second test tube position number.
6. The reference substance position assignment method according to any one of claims 1 to 5, wherein the information of the reference substance of the position to be assigned further includes a detection item of the reference substance, the reference substance of each position to be assigned is assigned a vacant test tube position, and after the correspondence relationship between the reference substance to which the vacant test tube position has been assigned and the position information of the test tube position is established, the method further includes:
distributing corresponding reagents for the reference substances according to the detection items of the reference substances, so that the reagents and the corresponding reference substances at the positions to be distributed are uniformly mixed to carry out detection of the corresponding items, and establishing the corresponding relation between the reference substances at the positions to be distributed and the identifications of the reagents.
7. The reference material position distribution method according to claim 6, wherein said reference material of each of said positions to be distributed is distributed with an idle test tube position, and after establishing the corresponding relationship between the reference material distributed with the idle test tube position and the position information of said test tube position, said method further comprises:
receiving an application calibration command;
generating test information of the reference substance according to the application calibration command, wherein the test information comprises information of the reference substance, position information of a tube position allocated to the reference substance and identification of a reagent allocated to the reference substance;
receiving a test starting command;
selecting a target sample analyzer from the sample analyzers according to the detection items of the reference substance;
controlling the sample transfer mechanism to convey the reference substance on the corresponding test tube position to the target sample analyzer according to the position information;
controlling the target sample analyzer to collect the reference substance;
and controlling the target sample analyzer to uniformly mix the collected reference substance with the corresponding reagent and detect corresponding items.
8. The reference material position distribution method according to claim 1, wherein before the obtaining of the information of the reference material of the preset position to be distributed, the method further comprises:
receiving an instruction to add the reference substance;
receiving user-input information of the added reference substance; the added reference substance is the reference substance of the location to be dispensed.
9. The reference mass location assignment method of claim 8, wherein prior to receiving the instruction to add the reference mass, the method further comprises:
and providing a setting interface of the reference substance, wherein a button for adding the reference substance and information for displaying the added reference substance are displayed on the setting interface, and the button for adding the reference substance is used for receiving the instruction for adding the reference substance.
10. The reference material position dispensing method of claim 9, wherein an automatic dispensing position button is further provided on the setup interface for receiving the instruction for the reference material dispensing position for the to-be-dispensed position.
11. A sample analysis system is characterized by comprising a sample transfer mechanism, a sample analyzer and a data management device,
the sample transfer mechanism is used for conveying a test tube rack provided with test tubes, the test tube rack is provided with a plurality of test tube positions, each test tube position is used for placing the corresponding test tube, the test tube is used for storing an object to be tested, the object to be tested comprises a reference substance, the test tube rack is provided with a test tube rack mark, each test tube position on the test tube rack is provided with a corresponding serial number,
the sample analyzer is used for detecting corresponding items of the object to be detected,
the data management device is connected with the sample transfer mechanism and the sample analyzer respectively, and is used for:
acquiring information of a preset reference substance at a position to be distributed, wherein the information of the reference substance at the position to be distributed comprises the type of the reference substance;
receiving an instruction for a reference material dispensing location for the location to be dispensed;
selecting a test tube rack of a corresponding type for the reference substance at the position to be distributed according to the type of the reference substance;
acquiring occupation information of test tube positions on the test tube rack corresponding to the type of the reference substance at the position to be distributed, wherein the occupation information comprises: occupied and idle;
distributing an idle test tube position for the reference substance of each position to be distributed, and establishing a corresponding relation between the reference substance distributed with the idle test tube position and the position information of the test tube position, wherein the position information comprises: test-tube rack sign and test tube position serial number.
12. The sample analysis system of claim 11, wherein the information about the reference substance at the location to be dispensed further comprises a category name and a concentration parameter of the reference substance, and the data management device is further configured to:
if the reference substances at the positions to be distributed comprise a plurality of reference substances, distributing idle test tube positions for the reference substances at the positions to be distributed in sequence according to a preset sequence; or
If the reference substances at the positions to be distributed comprise a plurality of reference substances with the same category names but different concentration parameters, idle test tube positions are sequentially distributed for the reference substances with the same category names but different concentration parameters according to the size sequence of the concentration parameters.
13. The sample analysis system of claim 12, wherein the data management device is further configured to:
and sequentially allocating idle test tube positions with the numbers from small to large for the reference substances with the same type names but different concentration parameters according to the sequence from small to large of the concentration parameters.
14. The sample analysis system of claim 11, wherein the reference substances at the positions to be dispensed include a first reference substance and a second reference substance having the same category name, the concentration parameter of the first reference substance is a first concentration parameter, the concentration parameter of the second reference substance is a second concentration parameter, and the data management device is further configured to:
distributing an idle first test tube position for the first reference substance, and establishing a corresponding relation between the first reference substance and the position information of the first test tube position, wherein the position information of the first test tube position comprises a first test tube rack identifier and a first test tube position number;
and distributing an idle second test tube position for the second reference substance, and establishing a corresponding relation between the second reference substance and the position information of the second test tube position, wherein the position information of the second test tube position comprises the first test tube rack identification and the second test tube position number.
15. The sample analysis system according to any one of claims 11 to 14, wherein the information of the reference substance at the position to be dispensed further includes a detection item of the reference substance, and the data management device is further configured to:
distributing corresponding reagents for the reference substances according to the detection items of the reference substances, so that the reagents and the corresponding reference substances at the positions to be distributed are uniformly mixed to carry out detection of the corresponding items, and establishing the corresponding relation between the reference substances at the positions to be distributed and the identifications of the reagents.
16. The sample analysis system of claim 15, wherein the data management device is further configured to:
receiving an application calibration command;
generating test information of the reference substance according to the application calibration command, wherein the test information comprises information of the reference substance, position information of a tube position allocated to the reference substance and identification of a reagent allocated to the reference substance;
receiving a test starting command;
selecting a target sample analyzer from the sample analyzers according to the detection items of the reference substance;
controlling the sample transfer mechanism to convey the reference substance on the corresponding test tube position to the target sample analyzer according to the position information;
controlling the target sample analyzer to collect the reference substance;
and controlling the target sample analyzer to uniformly mix the collected reference substance with the corresponding reagent and detect corresponding items.
17. The sample analysis system of claim 11, wherein the data management device is further configured to:
receiving an instruction to add the reference substance;
receiving user-input information of the added reference substance; the added reference substance is the reference substance of the location to be dispensed.
18. The sample analysis system of claim 17, wherein the data management device is further configured to:
and providing a setting interface of the reference substance, wherein a button for adding the reference substance and information for displaying the added reference substance are displayed on the setting interface, and the button for adding the reference substance is used for receiving the instruction for adding the reference substance.
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