CN112386539A - Shampoo product with effects of recovering scalp itching and desquamation - Google Patents

Abstract

The invention discloses a shampoo product with the effects of recovering scalp itching and desquamation, belonging to the field of cosmetics. The shampoo comprises the following substances by taking the total amount of the shampoo as 100 percent: the extract of herba Artemisiae Annuae accounts for 0.1-10% of the total amount, salicylic acid accounts for 0.3-3% of the total amount, and the rest is matrix of shampoo, and can be in the form of emulsion, gel, solution, or powder. The shampoo product contains the sweet wormwood extract and the salicylic acid active component, the sweet wormwood extract is a natural active substance, has small toxic and side effects, has broad-spectrum antifungal and antibacterial effects, and plays a role in factor treatment; the low-concentration salicylic acid can promote normal keratosis of the rash, has an obvious effect of resisting dandruff, plays a role in symptomatic treatment, complements the combination effect of the two, and improves the effect synergistically, so that the effects of recovering scalp pruritus and dandruff are achieved.

Description

Shampoo product with effects of recovering scalp itching and desquamation

Technical Field

The invention relates to a functional shampoo product, in particular to a shampoo product which contains sweet wormwood herb extract and salicylic acid active ingredients and has the effects of recovering scalp itch and desquamation, and belongs to the field of cosmetics.

Background

Scalp pruritus and desquamation diseases account for 2-5% of people, and may be related to sebaceous gland hypersecretion, malassezia furfur infection, bacterial infection, abnormal immune mechanism and the like. The diseases causing desquamation and itching of scalp mainly include seborrheic dermatitis (seborrhoeic dermatitis), psoriasis vulgaris (psoriasis vulgaris), folliculitis (folliculitis), tinea capitis (tinea capitis), pityriasis capitis and the like, and the clinical manifestations of the diseases mainly include scalp itching, erythema, pimple, scale, scab, alopecia and the like. When the disease condition of the patient is aggravated, the patient can choose to be treated in a hospital; when the disease condition is mild, a functional shampoo product with small toxic and side effects is preferred. In recent years, despite the existence of a plurality of brands of anti-dandruff and itching-relieving shampoo products on the market, a plurality of consumers still have unsatisfactory product effects, so that the research and development of novel effective shampoo products are significant, and the market prospect is wide.

Artemisia apiacea is dry overground part of Artemisia annua L of Compositae, has cold nature and bitter and pungent taste, can clear heat, has pungent and fragrant flavor, is good for dispersing yin heat to the outside, and has the effects of clearing deficiency heat, cooling blood, removing steam, relieving summer-heat and preventing malaria (national pharmacopoeia Commission, the people's republic of China pharmacopoeia, a department of Beijing, the Chinese medicine science and technology publisher 2015: 198). "Shen nong Ben Cao Jing" (Shen nong's herbal medicine) Zhongzhong hong: artemisia apiacea, bitter in taste and cold in flavor, is mainly used for scabies, itch, sores, fleas and the like, and is also named as Artemisia apiacea (for visiting, Pengpo, Shennong Ben Cao Jing, Beijing, Aster Press 2014, 243). According to the traditional Chinese medicine, the scalp itching and desquamation are mostly caused by heat, damp-heat and steaming up, or exogenous pathogenic factors such as exogenous summer-heat, dampness, dryness, fire and the like, or excessive eating of spicy food and fat, sweet and thick taste, which causes damp-heat in lung and stomach, and causes scalp eruption. Therefore, the sweet wormwood herb has the functions of clearing heat and cooling blood, killing parasites and relieving itching and the like, and can be used for treating diseases such as erythema, desquamation, pimple, pruritus, sore, carbuncle and the like.

From the aspect of western medicine, scientists in China take the lead to extract artemisinin from artemisia apiacea and further synthesize derivatives of the artemisinin, including dihydroartemisinin, artesunate, artemether, arteether and the like. The artemisia apiacea extract has the effects of inhibiting and killing trichophyton rubrum, trichophyton gypseum, epidermophyton floccosum, microsporum gypseum, candida albicans and other fungi, and has better curative effect on treating dermatophytosis than miconazole ointment (Chendeyu, xanthophyll, Zhengjuan. artemisia oil liniment antifungal experiment and curative effect observation, China J. dermatology, 1990,4(1): 18-19.). Recent studies by foreign researchers have found that essential oil of Artemisia annua has selective antimicrobial compounds and antibacterial membrane activity against gram-positive and gram-negative strains and yeast strains, and can affect the expression of relevant cells and soluble pathogenic factors (Marinas I C, Oprea E, Chifrius M C, et al.chemical composition and antisense activity of artemia annua essential oil from Romania [ J ]. Chem Biodiodes, 2015,12(10): 1554-1564.). Numerous patent documents in recent years relate to the effects in the aspects of sterilization, disinsection, antivirus and the like, the antibacterial spectrum and the effects are similar to those of the ketoconazole which is a commonly used broad-spectrum antifungal medicament at present, the effects on certain fungi can be stronger than those of the ketoconazole, and the adverse reaction is less; artemisinin can be made into various preparations, and can be used as topical agent for treating superficial fungal infection such as tinea manus and pedis, tinea corporis, tinea capitis, etc., and for preventing and treating dandruff (see patent CN1145224A) (Zhangxie, etc. Artemisinin compound new application related patent status analysis, Chinese invention and patent, 2018, 15(10): 06). The research provides experimental basis for the southernwood drugs to prevent and treat scalp erythema, desquamation, pruritus and the like caused by malassezia scalp fungi.

Wang Jiang et al have focused on the basis and clinical studies on the anti-inflammatory mechanism of Artemisia drugs (suppression of neutrophil chemotaxis), anti-follicular Demodex concentration, Treatment of rosacea and acne (Wang Jiang, Zhang Hai Qing. Artemisia succinate has an effect on neutrophil chemotactic function, journal of dermatology, 2004, 18 (7): 391. plum, Huyang, Anhuhua, Chengming, Zhang Haqing, Wang Gu Jiang. Artemisia J. oral Artesunate 31 cases of clinical observation for treating rosacea. journal of dermatology, 2015,29 (3): 330. 332. Wang Jiang, Gao, Li et al. Artemisia methyl ether in vitro anti-follicular Demodex. Activity analysis, journal of Chinese dermatology, 2016,49 (11): 201811. Guo-Jian Wang, Xiao-Yan Gao, Yun Wu et al. Vol.30, No.8,809-812. doi.org/10.1080/09546634.2019.1610549), and accumulates abundant experience in the prevention, treatment and rehabilitation of the diseases. Considering that the pathogenesis of the seborrheic dermatitis of the scalp is mainly that the rise of the level of androgenic hormones in adolescence leads to the development of sebaceous glands and the production of more grease, which is then infected with malassezia lipoidica, which decomposes fatty acids and stimulates the skin to cause inflammatory reaction to form the seborrheic dermatitis and the pityrosporum folliculitis. Therefore, the treatment target of the scalp seborrheic dermatitis is mainly focused on three aspects of inhibiting sebum secretion, resisting malassezia reproduction and resisting inflammatory medium.

Salicylic acid (Salicylic acid) is a classic antipyretic analgesic drug and is also a natural active ingredient, also known as beta-hydroxy acid (BHA), which is present in many plants as a very important natural active ingredient, such as: willow bark, Betula dulcis bark and Betula platyphylla. Salicylic acid has been widely used to treat pityriasis capitis, acne, rosacea, the problems related to skin such as pigmentation, skin aging and the like gradually show the important application value of salicylic acid in the fields of skin treatment and medical cosmetology along with the deep research on the clinical application of salicylic acid (i.e. single idoch, tianhuimin, particularly gorgeous. the application and prospect of supramolecular salicylic acid in medical cosmetology, Chinese cosmetology, 2019, (28),3: 171-. Salicylic acid has a history of nearly one hundred years, and salicylic acid with different concentrations has different pharmacological actions when being externally used, wherein 5% -10% of salicylic acid is mainly used for exfoliating, namely treating diseases such as hyperkeratosis of skin, epidermal hyperplasia and the like, such as palmoplantar keratosis, callus, perifollicular keratosis and the like; the 3% salicylic acid is a cutin promoter (single idol, tianhumin, Youyanzhi. supermolecule salicylic acid is applied and expected in medical cosmetology, Chinese cosmetology, 2019, (28),3: 171-. In the united states famous functional shampoo Dove (polyhefen shampoo), 3% salicylic acid component is contained. At present, no report and practical application related to the application of the artemisia apiacea extract and the salicylic acid to the hair washing product to realize the functions of recovering scalp pruritus and desquamation are found.

Disclosure of Invention

The invention aims to provide a shampoo product with effects of recovering scalp itching and desquamation, which comprises the following substances by taking the total amount of the shampoo product as 100 percent: 0.1-10% of sweet wormwood extract, 0.3-3% of salicylic acid and the balance of shampoo matrix.

In some embodiments of the shampoo compositions of the present invention, the components of the base may be surface active components, oils, creams, ions, foams, smoothness, thickeners, water-locking, colloids, solutions, powders.

In some embodiments of the shampoo compositions of the present invention, the formulation may be an emulsion (shampoo), a gel, a solution, or a powder.

In some embodiments of the shampoo of the present invention, the amount of the artemisia apiacea extract is 1-100g and the amount of the salicylic acid is 3-30g, based on 1000mL of the total amount of the shampoo.

One preferred embodiment of the invention is a hair washing cream (shampoo) which comprises 1-100g of sweet wormwood herb extract and 3-30g of salicylic acid, wherein the matrix contains water, a surfactant, a foaming agent, a smoothing agent, an antidandruff agent, a hair care and thickening agent and a water locking component, and the total volume of the hair washing cream (shampoo) is 1000 mL.

One preferred embodiment of the present invention is a shampoo gel comprising 1-100g of artemisia apiacea extract and 3-30g of salicylic acid, based on 1000mL of the total shampoo gel, wherein 10-80g of each of a pH adjuster and a surfactant, 0.25g of an antioxidant, 0.1-1.0 g of a metal chelator, 5-15mL of a permeation enhancer, and the balance of water are contained in a base.

A preferable embodiment of the invention is shampoo, which comprises 1-100g of sweet wormwood herb extract and 3-30g of salicylic acid based on the total amount of 1000mL of the shampoo, and the matrix contains surfactant, foaming agent, smoothing agent, antidandruff agent, water locking component and the balance of water.

The shampoo powder comprises 1-100g of sweet wormwood herb extract and 3-30g of salicylic acid, wherein the total amount of the shampoo powder is 1000g, and the matrix contains a surfactant, a smoothing agent, an antidandruff agent, a water locking component and the balance of starch.

Compared with the prior art, the invention has the beneficial effects that: the shampoo product contains the sweet wormwood herb extract and the salicylic acid active component, and has the effects of recovering scalp pruritus and desquamation. The sweet wormwood herb extract is a natural active substance, has small toxic and side effects, has spectral antifungal and antibacterial effects, and plays a role in factor treatment; the low-concentration salicylic acid promotes normal keratosis of the rash, has obvious effect of resisting scalp desquamation, plays a role in symptomatic treatment, is complementary in combination effect and synergistically enhanced in effect, and achieves the effect of treating both symptoms and root causes (simultaneous treatment of the symptomatic treatment and the symptomatic treatment).

It should be understood that all combinations of the foregoing concepts and additional concepts described in greater detail below can be considered as part of the inventive subject matter of this disclosure unless such concepts are mutually inconsistent.

The foregoing and other aspects, embodiments and features of the invention will be more fully understood from the following description. Additional aspects of the present invention, such as features and/or advantages of exemplary embodiments, will be apparent from the description which follows, or may be learned by practice of specific embodiments in accordance with the teachings of the present invention.

Detailed Description

The invention is further illustrated by the following examples, which are intended to be purely exemplary of the invention and are not intended to limit its scope in any way.

Raw material example 1 preparation of Artemisia annua extract (Artemisia annua oil)

(1) Raw material treatment: cutting fresh aerial parts of herba Artemisiae Annuae, and weighing.

(2) Artemisia annua extract (including Artemisia annua oil), prepared in paragraphs 0035 to 0040 of the specification of the referenced patent application (CN108478489A, moisturizing use of Artemisia annua extract and skin composition containing Artemisia annua extract), or purchased at qualified manufacturing companies.

Starting example 2 preparation of low concentration salicylic acid (3%)

Using the salicylic acid powder of the medicine raw material grade sold in the market, fully dissolving the salicylic acid powder by using a solvent compatible with a product matrix, adding the salicylic acid powder into the corresponding matrix, and uniformly mixing.

Product example 1

Referring to patent CN103393551B, a hair lotion (shampoo) was prepared, and the formulation was as follows:

the raw materials No. 1-3 are uniformly mixed by 1000mL of total amount to obtain the shampoo, which is used for cleaning hair and has the effects of recovering scalp itch and desquamation.

Product example 2

Shampoo gels were prepared according to patent application CN107213081A, with the following formulation:

the raw materials No. 1-8 are uniformly mixed by 1000mL of total amount to obtain the shampoo gel which is used for cleaning hair and has the effects of recovering scalp itch and desquamation.

Product example 3

Shampoo was prepared according to patent application CN 102652714 a, with the following formulation:

the shampoo is obtained by uniformly mixing the raw materials No. 1-3 in a total volume of 1000mL, and has the effects of recovering scalp itch and removing dandruff when used for cleaning hair.

Product example 4

Reference is made to patent application CN108451858A for the preparation of shampoo powders, the formulation of which is as follows:

the shampoo powder is obtained by uniformly mixing the raw materials No. 1-4 in a total amount of 1000g, and has the effects of recovering scalp itch and removing dandruff when used for cleaning hair.

Comparative product example 1

Serial number	Composition (I)	Content (wt.)
			1	Artemisia annua extract	20g
2	pH regulator	50g
			3	Surface active agent	50g
4	Antioxidant agent	0.25g
			5	Metal chelating agents	0.5g
6	Penetration enhancer	10mL
			7	Water (W)	Balance of

Compared with the product example 2, the components are the same except that no salicylic acid is added. The raw materials No. 1-7 are uniformly mixed by 1000mL of total amount to obtain the shampoo gel which is used for cleaning the hair and has no effects of recovering scalp itch and desquamation.

Comparative product example 2

Serial number	Composition (I)	Content (wt.)
			1	Salicylic acid	5g
2	pH regulator	50g
			3	Surface active agent	50g
4	Antioxidant agent	0.25g
			5	Metal chelating agents	0.5g
6	Penetration enhancer	10mL
			7	Water (W)	Balance of

Compared with the product of example 2, the ingredients are the same except that the artemisia apiacea extract is not added. The raw materials No. 1-7 are uniformly mixed by 1000mL of total amount to obtain the shampoo gel which is used for cleaning the hair and has no effects of recovering scalp itch and desquamation.

Clinical trial example 1 shampoo of Artemisia annua extract in combination with salicylic acid for the treatment of seborrheic dermatitis of scalp (dandruff)

1. Clinical data: 102 patients with seborrheic dermatitis of the skin department in outpatient department of Zhou hospital affiliated to Shanghai health medical college were selected from 3 months in 2018 to 12 months in 2018. All cases were randomized into:

51 cases, 23 cases for men and 28 cases for women in the treatment group (product); age 18-55 years, mean (31.35 ± 11.67) years, course 2-36 months, mean (14.25 ± 8.30 months;

in the control group (the product substrate), 51 patients, 29 men and 22 women aged 20-53 years, mean (29.67 +/-12.25) years, 3-28 months of course and mean (18.67 +/-1.55) months.

The data of sex, age, course of disease, disease condition, etc. of two groups of patients are statistically processed, the difference is not statistically significant (P >0.05), and the two groups are comparable.

2. Diagnostic criteria: meets the diagnosis standard of head seborrheic dermatitis in the 2 nd edition of Chinese clinical dermatology compiled by Zhao dialectic ministry.

Inclusion criteria were: other drugs for treating seborrheic dermatitis (including internal and external drugs) are not used within 1 month, and the other drugs are not used during the treatment period.

Exclusion criteria: oral administration of antifungal agents; pregnant women and children; patients with serious dysfunction of liver and kidney and mental diseases.

3. The treatment method comprises the following steps: the treatment group used the shampoo (containing Artemisia annua extract and salicylic acid) and the control group used the shampoo base (i.e. not containing Artemisia annua extract and salicylic acid).

4. The therapeutic effect judgment standard is as follows: evaluation was made based on the area of skin lesions, erythema, desquamation, and itching.

And (3) healing: the clinical symptoms and signs are resolved by more than 95%.

The effect is shown: the clinical manifestation is reduced by 80 to 94 percent.

Improvement: clinical performance is reduced by 50-79%.

And (4) invalidation: no improvement in clinical manifestations.

5. As a result: the results of treatment for two groups of patients with seborrheic dermatitis are shown in table 1.

TABLE 1

The SPSS14 software chi fang test shows that the difference between the effective rates of the treatment group and the control group has statistical significance (P is 0.012066, P is less than 0.05). The treatment group had 1 dry scalp discomfort and the next day had no dry scalp discomfort, and when the application was repeated, the shampoo took less than 5 minutes on the scalp, and no adverse reaction occurred in the control group.

In summary, the research and development of safe and effective functional shampoo products are urgent needs of the majority of patients with dandruff, and are social responsibility of medical workers and cosmetic developers. The invention adopts the combined formula of the sweet wormwood herb extract and the salicylic acid, the sweet wormwood herb extract and the salicylic acid are both natural plant extracts, can also be artificially synthesized, and have the characteristics of low toxicity, high safety, strong reliability and the like compared with general pharmacological activities. Clinical trial research shows that the formula has good effects of recovering desquamation and pruritus of scalp, stays on scalp for about 5 minutes according to the shampoo, does not generate adverse reaction of skin and the whole body, and can be used for developing functional shampoo.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. It will be readily apparent to those skilled in the art that various modifications to these embodiments and the generic principles defined herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above-described embodiments. Those skilled in the art should appreciate that many modifications and variations are possible in light of the above teaching without departing from the scope of the invention.

Claims (8)

1. A shampoo product with the effects of recovering scalp itch and desquamation is characterized by comprising the following substances by taking the total amount of the shampoo product as 100 percent: 0.1-10% of sweet wormwood extract, 0.3-3% of salicylic acid and the balance of shampoo matrix.

2. The shampoo product of claim 1 wherein the components of the base are selected from the group consisting of surface active components, oils, creams, ions, foams, smoothness, thickening, water locking, gels, solutions, powders.

3. The shampoo article according to claim 1 or 2, characterized in that the formulation is selected from the group consisting of emulsions, gels, solutions, powders.

4. The shampoo product of claim 3, wherein the amount of said Artemisia annua extract is 1-100g and the amount of said salicylic acid is 3-30g, based on 1000mL of the total shampoo product.

5. The shampoo product of claim 4, wherein the shampoo product is a shampoo, and comprises 1-100g of Artemisia annua extract and 3-30g of salicylic acid, wherein the shampoo is 1000mL, and the matrix contains water, surfactant, foaming agent, smoothing agent, dandruff removing agent, hair care and thickening agent, and water locking component.

6. The shampoo product of claim 4, wherein the shampoo product is a shampoo gel comprising 1-100g of Artemisia annua extract and 3-30g of salicylic acid, based on 1000mL of the total shampoo gel, and the base comprises 10-80g of pH regulator and surfactant, 0.25g of antioxidant, 0.1-1.0 g of metal chelator, 5-15mL of penetration enhancer, and balance of water.

7. The shampoo product of claim 4, wherein the shampoo product is a shampoo, comprising 1-100g of Artemisia annua extract and 3-30g of salicylic acid, wherein the shampoo is 1000mL, and the matrix contains surfactant, foaming agent, smoothing agent, antidandruff agent, and water-locking component, and the balance is water.

8. The shampoo product of claim 4, wherein the shampoo product is a shampoo powder, comprising 1-100g of Artemisia annua extract and 3-30g of salicylic acid, wherein the matrix contains surfactant, smoothing agent, antidandruff agent, water-locking component, and starch in balance, wherein the total amount of the shampoo powder is 1000 g.