CN112350693A - Pulse equipment, pulse output device and high-voltage electric pulse tumor therapeutic apparatus - Google Patents
Pulse equipment, pulse output device and high-voltage electric pulse tumor therapeutic apparatus Download PDFInfo
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- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 41
- 230000001225 therapeutic effect Effects 0.000 title claims description 33
- 238000002955 isolation Methods 0.000 claims abstract description 102
- 238000005259 measurement Methods 0.000 claims abstract description 71
- 238000007599 discharging Methods 0.000 claims abstract description 40
- 238000009532 heart rate measurement Methods 0.000 claims abstract description 21
- 239000000758 substrate Substances 0.000 claims description 64
- 238000012545 processing Methods 0.000 claims description 43
- 238000001514 detection method Methods 0.000 claims description 30
- 230000005693 optoelectronics Effects 0.000 claims description 18
- 230000000149 penetrating effect Effects 0.000 claims description 9
- 239000003990 capacitor Substances 0.000 claims description 7
- 238000002560 therapeutic procedure Methods 0.000 claims description 5
- 238000012544 monitoring process Methods 0.000 claims description 3
- 239000013307 optical fiber Substances 0.000 claims description 3
- 230000005540 biological transmission Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 7
- 230000001276 controlling effect Effects 0.000 description 14
- 238000000034 method Methods 0.000 description 9
- 230000008569 process Effects 0.000 description 8
- 238000010586 diagram Methods 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 6
- 230000008054 signal transmission Effects 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 230000000875 corresponding effect Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 230000005684 electric field Effects 0.000 description 3
- 230000036039 immunity Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
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- H—ELECTRICITY
- H03—ELECTRONIC CIRCUITRY
- H03K—PULSE TECHNIQUE
- H03K3/00—Circuits for generating electric pulses; Monostable, bistable or multistable circuits
- H03K3/02—Generators characterised by the type of circuit or by the means used for producing pulses
- H03K3/53—Generators characterised by the type of circuit or by the means used for producing pulses by the use of an energy-accumulating element discharged through the load by a switching device controlled by an external signal and not incorporating positive feedback
- H03K3/57—Generators characterised by the type of circuit or by the means used for producing pulses by the use of an energy-accumulating element discharged through the load by a switching device controlled by an external signal and not incorporating positive feedback the switching device being a semiconductor device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
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- H—ELECTRICITY
- H03—ELECTRONIC CIRCUITRY
- H03K—PULSE TECHNIQUE
- H03K3/00—Circuits for generating electric pulses; Monostable, bistable or multistable circuits
- H03K3/02—Generators characterised by the type of circuit or by the means used for producing pulses
- H03K3/26—Generators characterised by the type of circuit or by the means used for producing pulses by the use, as active elements, of bipolar transistors with internal or external positive feedback
- H03K3/28—Generators characterised by the type of circuit or by the means used for producing pulses by the use, as active elements, of bipolar transistors with internal or external positive feedback using means other than a transformer for feedback
- H03K3/281—Generators characterised by the type of circuit or by the means used for producing pulses by the use, as active elements, of bipolar transistors with internal or external positive feedback using means other than a transformer for feedback using at least two transistors so coupled that the input of one is derived from the output of another, e.g. multivibrator
- H03K3/286—Generators characterised by the type of circuit or by the means used for producing pulses by the use, as active elements, of bipolar transistors with internal or external positive feedback using means other than a transformer for feedback using at least two transistors so coupled that the input of one is derived from the output of another, e.g. multivibrator bistable
- H03K3/2865—Generators characterised by the type of circuit or by the means used for producing pulses by the use, as active elements, of bipolar transistors with internal or external positive feedback using means other than a transformer for feedback using at least two transistors so coupled that the input of one is derived from the output of another, e.g. multivibrator bistable ensuring a predetermined initial state when the supply voltage has been applied; storing the actual state when the supply voltage fails
-
- H—ELECTRICITY
- H03—ELECTRONIC CIRCUITRY
- H03K—PULSE TECHNIQUE
- H03K3/00—Circuits for generating electric pulses; Monostable, bistable or multistable circuits
- H03K3/02—Generators characterised by the type of circuit or by the means used for producing pulses
- H03K3/353—Generators characterised by the type of circuit or by the means used for producing pulses by the use, as active elements, of field-effect transistors with internal or external positive feedback
- H03K3/356—Bistable circuits
- H03K3/356008—Bistable circuits ensuring a predetermined initial state when the supply voltage has been applied; storing the actual state when the supply voltage fails
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Abstract
本申请涉及一种脉冲设备、脉冲输出装置以及高压电脉冲肿瘤治疗仪，所述脉冲设备包括充电板、脉冲产生板和放电板；充电板上包括相互隔离设置的充电电路和充电测控电路；充电电路电连接充电测控电路；脉冲产生板上包括相互隔离设置的脉冲产生电路和脉冲测控电路；脉冲产生电路电连接脉冲测控电路；放电板上包括相互隔离设置的放电电路和放电测控电路；放电电路电连接放电测控电路；其中，充电电路、脉冲产生电路、放电电路依次电连接；放电电路用于电连接高压电脉冲肿瘤治疗仪的针道面板，本申请增加了脉冲设备的电气隔离效果，提高了输出的脉冲质量。
The present application relates to a pulse device, a pulse output device, and a high-voltage electric pulse tumor treatment instrument, wherein the pulse device includes a charging board, a pulse generating board and a discharging board; the charging board includes a charging circuit and a charging measurement and control circuit that are isolated from each other; The charging circuit is electrically connected to the charging measurement and control circuit; the pulse generation board includes a pulse generation circuit and a pulse measurement and control circuit that are isolated from each other; the pulse generation circuit is electrically connected to the pulse measurement and control circuit; the discharge board includes a mutually isolated discharge circuit and a discharge measurement and control circuit; The circuit is electrically connected to the discharge measurement and control circuit; wherein, the charging circuit, the pulse generation circuit, and the discharge circuit are electrically connected in sequence; the discharge circuit is used to electrically connect the needle track panel of the high-voltage electric pulse tumor treatment instrument, and the present application increases the electrical isolation effect of the pulse device , which improves the output pulse quality.
Description
Technical Field
The application relates to the technical field of medical equipment, in particular to pulse equipment, a pulse output device and a high-voltage electric pulse tumor therapeutic apparatus.
Background
The high-voltage electric pulse tumor therapeutic equipment is a new type equipment for curing malignant tumor, and combines several techniques of biological medical engineering, high-voltage new technology, modern power electronic technology, computer technology and microelectronic technology, etc. The working process of the high-voltage electric pulse tumor therapeutic apparatus is generally as follows: the instantaneous electric field intensity of the electric field pulse applied to the cell is higher than 1kV/cm (kilovolt per centimeter), the molecular permeability of the cell is greatly improved, and then the electroporation phenomenon is generated, and irreversible electric breakdown occurs along with the continuous increase of the pulse electric field intensity, so that the mechanical rupture of the cell membrane is caused until the cell dies.
At present, the quality of the high-voltage electric pulse tumor therapeutic apparatus needs to be continuously improved, and in the implementation process, the inventor finds that at least the following problems exist in the traditional technology: the traditional high-voltage electric pulse tumor therapeutic apparatus has poor electric isolation effect, resulting in poor output pulse quality.
Disclosure of Invention
Therefore, it is necessary to provide a pulse device, a pulse output device and a high-voltage electric pulse tumor therapeutic apparatus, aiming at the problem that the traditional high-voltage electric pulse tumor therapeutic apparatus has poor electrical isolation effect and poor output pulse quality.
In order to achieve the above object, in one aspect, the embodiments of the present application provide a pulse device, which is applied to a high-voltage electric pulse oncology therapeutic apparatus; comprises a charging plate, a pulse generating plate and a discharging plate;
the charging panel comprises a charging circuit and a charging measurement and control circuit which are arranged in an isolated way; the charging circuit is electrically connected with the charging measurement and control circuit;
the pulse generating board comprises a pulse generating circuit and a pulse measuring and controlling circuit which are arranged in an isolated way; the pulse generating circuit is electrically connected with the pulse measurement and control circuit;
the discharge board comprises a discharge circuit and a discharge measurement and control circuit which are arranged in an isolated manner; the discharge circuit is electrically connected with the discharge measurement and control circuit;
the charging circuit, the pulse generating circuit and the discharging circuit are electrically connected in sequence; the discharge circuit is used for electrically connecting the needle passage panel of the high-voltage electric pulse tumor therapeutic apparatus.
In one embodiment, the charging panel further comprises a first substrate, the charging circuit is arranged in a first area on the first substrate, the charging measurement and control circuit is arranged in a second area on the first substrate, and a first isolation groove penetrating through the first substrate is formed between the first area and the second area;
the pulse generating board further comprises a second substrate, the pulse generating circuit is arranged in a third area on the second substrate, the pulse measuring and controlling circuit is arranged in a fourth area on the second substrate, and a second isolation groove penetrating through the second substrate is formed between the third area and the fourth area;
the discharge board further comprises a third substrate, the discharge circuit is arranged in a fifth area on the third substrate, the discharge measurement and control circuit is arranged in a sixth area on the third substrate, and a third isolation groove penetrating through the third substrate is formed between the fifth area and the sixth area.
In one embodiment, the charging panel further comprises a first substrate and a first adapter plate mechanically connected with the first substrate, the charging circuit is arranged on the first substrate, and the charging measurement and control circuit is arranged on the first adapter plate;
the pulse generating board further comprises a second substrate and a second adapter board mechanically connected with the second substrate, the pulse generating circuit is arranged on the second substrate, and the pulse measuring and controlling circuit is arranged on the second adapter board;
the discharge board further comprises a third substrate and a third adapter plate mechanically connected with the third substrate, the discharge circuit is arranged on the third substrate, and the discharge measurement and control circuit is arranged on the third adapter plate.
In one embodiment, the charging circuit comprises a charging path control circuit, a charging capacitor bank and a discharging path control circuit which are electrically connected in sequence; the discharge path control circuit is electrically connected with the pulse generating circuit;
the charging measurement and control circuit comprises a charging control circuit and a charging signal detection circuit;
the charging control circuit is connected with the charging path control circuit; the charging signal detection circuit is electrically connected with the discharging path control circuit or the charging capacitor bank.
In one embodiment, the pulse generating circuit comprises a pulse generator, a protection circuit, a pulse detection circuit and an output path control circuit which are electrically connected in sequence; the output path control circuit is electrically connected with the discharge circuit;
the pulse measurement and control circuit comprises a pulse control circuit and a pulse signal detection circuit;
the pulse control circuit is electrically connected with the pulse generator; the pulse signal detection circuit is electrically connected with the output channel control circuit.
In one embodiment, the discharge circuit includes a pin lane select circuit; the needle channel circuit selection circuit is used for electrically connecting a needle channel panel of the high-voltage electric pulse tumor therapeutic apparatus;
the discharge measurement and control circuit comprises a discharge control circuit and a discharge signal detection circuit;
the discharge control circuit and the discharge signal detection circuit are respectively connected with the needle channel selection circuit.
On the other hand, the embodiment of the application also provides a pulse output device, which comprises the pulse equipment; also includes a control circuit;
the control circuit comprises a controller, a signal output circuit and a photoelectric isolation circuit;
the signal output circuit is respectively and electrically connected with the controller and the photoelectric isolation circuit; the photoelectric isolation circuit is respectively and electrically connected with the controller, the charging measurement and control circuit, the pulse measurement and control circuit and the discharging measurement and control circuit.
In one embodiment, the control circuit further comprises a Buffer module;
the Buffer module is respectively and electrically connected with the controller, the signal output circuit and the photoelectric isolation circuit.
In one embodiment, the optoelectronic isolation circuit comprises:
the first linear optical coupler isolator is used for carrying out photoelectric isolation processing on the PWM wave control signal sent by the controller, and transmitting the PWM wave control signal after the photoelectric isolation processing to a power supply system of the high-voltage electric pulse tumor therapeutic apparatus;
the linear optical coupler isolator string is used for carrying out photoelectric isolation processing on an analog signal sent by the pulse equipment and transmitting the analog signal subjected to the photoelectric isolation processing to the controller so that the controller can identify the running state of the pulse equipment according to the analog signal; the linear optocoupler isolator string comprises a second linear optocoupler isolator and a third linear optocoupler isolator connected with the second linear optocoupler isolator;
the optical fiber isolator is used for carrying out photoelectric isolation processing on the pulse signal sent by the signal output circuit and transmitting the pulse signal after the photoelectric isolation processing to the pulse measurement and control circuit; the charging control circuit is also used for carrying out photoelectric isolation processing on the charging control signal sent by the controller and transmitting the charging control signal subjected to the photoelectric isolation processing to the charging measurement and control circuit; the controller is also used for carrying out photoelectric isolation processing on the discharge control signal sent by the controller and transmitting the discharge control signal subjected to the photoelectric isolation processing to the discharge measurement and control circuit;
the optical coupler isolator is used for realizing the photoelectric isolation transmission of signals between the controller and external computer equipment; and the controller is also used for carrying out photoelectric isolation processing on the level signal sent by the external equipment and transmitting the level signal after the photoelectric isolation processing to the controller.
In another aspect, the present application further provides a high-voltage electric pulse tumor therapeutic apparatus, which includes the pulse output device; the RFID detection module is connected with the needle track panel;
the needle channel panel is connected with the discharge circuit; the RFID detection module is connected with the photoelectric isolation circuit.
One of the above technical solutions has the following advantages and beneficial effects:
the pulse device provided by each embodiment of the application comprises a charging plate, a pulse generating plate and a discharging plate; the charging panel comprises a charging circuit and a charging measurement and control circuit which are arranged in an isolated way; the charging circuit is electrically connected with the charging measurement and control circuit; the pulse generating board comprises a pulse generating circuit and a pulse measuring and controlling circuit which are arranged in an isolated way; the pulse generating circuit is electrically connected with the pulse measurement and control circuit; the discharge board comprises a discharge circuit and a discharge measurement and control circuit which are arranged in an isolated manner; the discharge circuit is electrically connected with the discharge measurement and control circuit; the charging circuit, the pulse generating circuit and the discharging circuit are electrically connected in sequence; the discharge circuit is used for electrically connecting the needle channel panel of the high-voltage electric pulse tumor therapeutic apparatus, and the electric isolation circuit electrically isolates all parts of circuits, thereby increasing the electric isolation effect of the pulse apparatus and improving the output pulse quality.
Drawings
FIG. 1 is a schematic diagram of a pulse device in one embodiment;
FIG. 2 is a schematic structural diagram of a pulse device in another embodiment;
FIG. 3 is a schematic structural diagram of a pulse output apparatus in one embodiment;
fig. 4 is a schematic structural view of a pulse output device in another embodiment;
FIG. 5 is a schematic structural diagram of a high-voltage electric pulse tumor therapy apparatus according to an embodiment;
FIG. 6 is a schematic structural diagram of another embodiment of the high-voltage electric pulse tumor therapy apparatus;
FIG. 7 is a schematic structural diagram of a high-voltage electric pulse tumor therapy apparatus according to still another embodiment.
Detailed Description
To facilitate an understanding of the present application, the present application will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present application are shown in the drawings. This application may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "electrically" or "mechanically" connected to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "disposed," "one end," "the other end," and the like as used herein are for illustrative purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the description of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
In order to solve the problem of poor electrical isolation effect of the conventional high-voltage electric pulse tumor therapeutic apparatus, which results in poor quality of output pulses, referring to fig. 1, in one embodiment, a pulse device is provided, which is applied to the high-voltage electric pulse tumor therapeutic apparatus; comprises a charging plate 11, a pulse generating plate 13 and a discharging plate 15;
the charging panel 11 comprises a charging circuit 111 and a charging measurement and control circuit 113 which are arranged in an isolated manner; the charging circuit 111 is electrically connected with the charging measurement and control circuit 113;
the pulse generating board 13 comprises a pulse generating circuit 131 and a pulse measuring and controlling circuit 133 which are arranged in an isolated manner; the pulse generating circuit 131 is electrically connected with the pulse measuring and controlling circuit 133;
the discharge plate 15 comprises a discharge circuit 151 and a discharge measurement and control circuit 153 which are arranged in an isolated manner; the discharge circuit 151 is electrically connected with the discharge measurement and control circuit 153;
wherein, the charging circuit 111, the pulse generating circuit 131 and the discharging circuit 151 are electrically connected in sequence; the discharge circuit 151 is used for electrically connecting the needle passage panel of the high-voltage electric pulse tumor therapeutic apparatus.
It should be noted that the charging board is used to connect an external power supply or a power supply system of the high-voltage electric pulse tumor therapeutic apparatus for charging, so as to provide a sufficient and stable high-voltage signal for the pulse generating board to generate the high-voltage pulse. The charging panel comprises a charging circuit and a charging measurement and control circuit, wherein the charging circuit is mainly used for storing electric energy, the charging measurement and control circuit is used for controlling the charging and discharging of the charging circuit and detecting signals or states generated by the charging circuit in the operation process, such as whether the charging panel is fully charged, charging voltage/current, discharging voltage/current, whether a discharging channel is opened, whether the charging channel is opened and the like. Specifically, the charging panel is not in direct contact with the pulse generating panel, when the pulse generating panel of the control box outputs a high-voltage signal, the charging panel needs to open a discharging channel on the charging panel, and the charging measurement and control circuit detects whether the discharging channel is opened or not in the process. The charging panel consumes electric quantity in the process of discharging to the pulse generating circuit, the voltage or current at two ends of a capacitor bank of the charging panel can be reduced, the charging measurement and control circuit detects the discharging voltage/current in real time, and when the discharging voltage/current is detected to be smaller than an initial set value, the charging panel is controlled to be charged again. In the charging process of the charging panel, the charging measurement and control circuit detects whether a charging channel is opened or not and detects charging voltage/current, the charging panel is prevented from being damaged due to overlarge charging voltage/current, and when the charging measurement and control circuit detects that the charging panel reaches the electric capacity of the charging panel, the charging is controlled to stop, and the charging panel is prevented from being overcharged.
In one example, referring to fig. 2, the charging circuit 111 includes a charging path control circuit 211, a charging capacitor bank 213, and a discharging path control circuit 215, which are electrically connected in sequence; the discharge path control circuit 215 is electrically connected to the pulse generation circuit 131; the charging measurement and control circuit 113 comprises a charging control circuit 217 and a charging signal detection circuit 219; the charging control circuit 217 is connected with the charging path control circuit 211; the charge signal detection circuit 219 is electrically connected to the discharge path control circuit 215 or the charge capacitor bank 213.
The pulse generating plate is used for receiving the high-voltage signal output by the charging plate and converting the high-voltage signal into a high-voltage pulse. The pulse generating board comprises a pulse generating circuit and a pulse measuring and controlling circuit, wherein the pulse generating circuit is used for converting a high-voltage signal into a high-voltage pulse, the pulse measuring and controlling circuit is used for controlling the pulse generating circuit to generate the high-voltage pulse and detecting signals or states generated by the pulse generating circuit in the operation process, for example, parameters (pulse width, pulse period and pulse number) of the high-voltage pulse output by the pulse generating circuit are judged, whether the output high-voltage pulse meets the initial setting requirement or not, whether an output channel of the pulse generating circuit is opened or not and the like according to the detected parameters.
In one example, referring to fig. 2, the pulse generation circuit 131 includes a pulse generator 221, a protection circuit 223, a pulse detection circuit 225, and an output path control circuit 227 electrically connected in this order; the output path control circuit 227 is electrically connected to the discharge circuit 151; the pulse measurement and control circuit 133 comprises a pulse control circuit 229 and a pulse signal detection circuit 231; the pulse control circuit 229 is electrically connected to the pulse generator 221; the pulse signal detection circuit 231 is electrically connected to the output path control circuit 227.
The discharge plate is used for receiving the high-voltage pulse output by the pulse generating plate and outputting the high-voltage pulse through a needle channel selected on a needle channel panel of the high-voltage electric pulse tumor therapeutic apparatus. The discharge board comprises a discharge circuit and a discharge measurement and control circuit, wherein the discharge circuit is used for selecting a needle channel on a needle channel panel to output high-voltage pulses, the discharge measurement and control circuit is used for controlling the discharge circuit to output the high-voltage pulses and outputting signals or states generated by discharge current in the operation process, for example, the discharge measurement and control circuit detects parameters of the high-voltage pulses output by the discharge circuit, detects the needle channel selected on the needle channel panel, detects discharge voltage/current of the discharge circuit, detects whether a discharge channel of the discharge circuit is opened or not, and the like.
In one example, referring to fig. 2, discharge circuit 151 includes a pin lane select circuit 233; the needle channel path selection circuit 233 is used for electrically connecting a needle channel panel of the high-voltage electric pulse tumor therapeutic apparatus; the discharge measurement and control circuit 153 comprises a discharge control circuit 235 and a discharge signal detection circuit 237; the discharge control circuit 235 and the discharge signal detection circuit 237 are connected to the needle passage selection circuit 233.
In order to enhance the electrical isolation between circuits, it is necessary to isolate the high-voltage circuit (charging circuit, pulse generating circuit, discharging circuit) from the low-voltage circuit (charging measurement and control circuit, pulse measurement and control circuit, discharging measurement and control circuit), and two isolation methods are provided below, but not limited to these two isolation methods:
in one example, the charging panel further comprises a first substrate, the charging circuit is arranged in a first area on the first substrate, the charging measurement and control circuit is arranged in a second area on the first substrate, and a first isolation groove penetrating through the first substrate is formed between the first area and the second area;
the pulse generating board further comprises a second substrate, the pulse generating circuit is arranged in a third area on the second substrate, the pulse measuring and controlling circuit is arranged in a fourth area on the second substrate, and a second isolation groove penetrating through the second substrate is formed between the third area and the fourth area;
the discharge board further comprises a third substrate, the discharge circuit is arranged in a fifth area on the third substrate, the discharge measurement and control circuit is arranged in a sixth area on the third substrate, and a third isolation groove penetrating through the third substrate is formed between the fifth area and the sixth area.
In another example, the charging panel further comprises a first substrate and a first adapter plate mechanically connected with the first substrate, the charging circuit is arranged on the first substrate, and the charging measurement and control circuit is arranged on the first adapter plate;
the pulse generating board further comprises a second substrate and a second adapter board mechanically connected with the second substrate, the pulse generating circuit is arranged on the second substrate, and the pulse measuring and controlling circuit is arranged on the second adapter board;
the discharge board further comprises a third substrate and a third adapter plate mechanically connected with the third substrate, the discharge circuit is arranged on the third substrate, and the discharge measurement and control circuit is arranged on the third adapter plate.
In the embodiments of the pulse device, the pulse device comprises a charging plate, a pulse generating plate and a discharging plate; the charging panel comprises a charging circuit and a charging measurement and control circuit which are arranged in an isolated way; the charging circuit is electrically connected with the charging measurement and control circuit; the pulse generating board comprises a pulse generating circuit and a pulse measuring and controlling circuit which are arranged in an isolated way; the pulse generating circuit is electrically connected with the pulse measurement and control circuit; the discharge board comprises a discharge circuit and a discharge measurement and control circuit which are arranged in an isolated manner; the discharge circuit is electrically connected with the discharge measurement and control circuit; the charging circuit, the pulse generating circuit and the discharging circuit are electrically connected in sequence; the discharge circuit is used for electrically connecting the needle way panel of the high-voltage electric pulse tumor therapeutic apparatus, the charging part, the pulse generating part and the discharging part are independently arranged into plates, and the charging plate, the pulse generating plate and the relevant circuits on the discharge plate are arranged in an isolated mode, so that the electrical isolation effect of pulse equipment is improved, and the output pulse quality is improved.
In one embodiment, referring to fig. 3, there is provided a pulse output apparatus comprising a pulse device according to the various embodiments of the pulse device of the present application; further comprises a control circuit 31;
the control circuit 31 includes a controller 311, a signal output circuit 313 and a photoelectric isolation circuit 315;
the signal output circuit 313 is electrically connected with the controller 311 and the photoelectric isolation circuit 314 respectively; the photoelectric isolation circuit 315 is electrically connected to the controller 311, the charging measurement and control circuit 113, the pulse measurement and control circuit 133 and the discharging measurement and control circuit 153, respectively.
It should be noted that, in a control scenario, the controller is configured to generate pulse parameters (including pulse period, pulse width, and number of pulses) and output a signal output circuit; the signal output circuit is used for generating and outputting a pulse signal according to the pulse parameter when the pulse parameter is smaller than a preset safety threshold value; the photoelectric isolation circuit is used for carrying out photoelectric isolation processing on the pulse signals and transmitting the pulse signals subjected to the photoelectric isolation processing to the pulse measurement and control circuit, and the pulse measurement and control circuit controls the pulse generation circuit to generate high-voltage pulses according to the pulse signals.
The above control scenario is specifically described as follows: and a user inputs an instruction to the controller according to actual requirements, and the controller generates corresponding pulse parameters according to the instruction. The controller generates pulse parameters and writes the pulse parameters into the signal output circuit. The pulse parameters are used to characterize the pulse signal, which includes the pulse period, pulse width, and number of pulses. In one example, the controller includes a Central Processing Unit (CPU) module, which is connected to the signal output circuit.
The signal output circuit is internally provided with a preset safety threshold in advance, after the pulse parameter is written in by the controller, the signal output circuit judges whether the pulse parameter is smaller than the preset safety threshold, and if the pulse parameter is smaller than the preset safety threshold, the signal output circuit generates a pulse signal according to the pulse parameter, so that the safety of pulse signal output is improved, and the safety of the controller for generating and outputting the pulse signal is improved. In one example, the signal output circuit may be a programmable logic or a processor, or other device for generating a pulse signal. Before generating the pulse signal, the signal output circuit needs to judge whether the pulse period of the pulse parameter is smaller than the preset pulse period, whether the pulse width of the pulse parameter is smaller than the preset pulse width and whether the pulse number of the pulse parameter is smaller than the preset pulse number, and if the pulse period of the pulse parameter is smaller than the preset pulse period, the pulse width of the pulse parameter is smaller than the preset pulse width and the pulse number of the pulse parameter is smaller than the preset pulse number, the signal output circuit generates the pulse signal according to the pulse parameter. In one example, a preset safety threshold may be configured in the controller, and the controller determines whether the pulse parameter is smaller than the preset safety threshold after generating the pulse parameter according to an instruction input by a user, and writes the pulse parameter into the signal output circuit if the pulse parameter is smaller than the preset safety threshold. In one example, the signal output circuit is a digital signal output circuit.
To further enhance the immunity to interference of the pulse signal and the accuracy of outputting the pulse signal, in one example, the signal output circuit is configured to output a high level when no pulse signal is output.
In another control scenario, the control circuit interacts with the charging and discharging panel presence signals in the pulse device, and also interacts with the external device presence signal, as described in detail below:
in one example, the controller is used for transmitting a control signal sent by the controller to a charging plate, a discharging plate or a high-voltage electric pulse tumor therapeutic apparatus after photoelectric isolation processing; wherein, the control signal is used for indicating the charging plate, the discharging plate or the high-voltage electric pulse tumor therapeutic apparatus to execute corresponding actions; the control signal includes a charge control signal, a PWM (Pulse Width Modulation) wave control signal, and/or a discharge control signal. Specifically, the charging control signal is transmitted to the charging measurement and control circuit to instruct the charging measurement and control circuit to control the charging circuit to start or stop charging; transmitting the PWM wave control signal to a power supply system to indicate the power supply system to output corresponding voltage; and the discharge control signal is transmitted to the discharge measurement and control circuit so as to indicate the discharge measurement and control circuit to control the discharge circuit to start or stop discharging.
In one example, the photoelectric isolation circuit is further used for performing photoelectric isolation processing on the analog signal sent by the charging plate, the pulse generating plate or the discharging plate, and transmitting the analog signal after the photoelectric isolation processing to the controller;
and the controller is also used for identifying the running state of the charging plate, the pulse generating plate or the discharging plate according to the corresponding analog signals.
It should be noted that, the controller is to control each of the charging panel, the pulse generating panel and the discharging panel, and also to monitor the operating states of the charging panel, the pulse generating panel and the discharging panel, so as to ensure the safe and stable operation of the charging panel, the pulse generating panel and the discharging panel, specifically, the charging measurement and control circuit collects the analog signal of the charging circuit and feeds back the analog signal to the controller through the photoelectric isolation circuit, and the controller can identify whether the charging circuit is fully charged, whether the charging circuit is currently in the charging state, and the like according to the analog signal; the pulse measurement and control circuit collects an analog signal of the pulse generation circuit and feeds back the analog signal to the controller through the photoelectric isolation circuit, and the controller identifies whether the pulse generation circuit can normally generate a pulse signal, parameters of the pulse signal and the like according to the analog signal; the discharge measurement and control circuit collects analog signals of the discharge circuit and feeds back the analog signals to the controller through the photoelectric isolation circuit, and the controller identifies discharge voltage, discharge needle channels and the like of the discharge circuit according to the analog signals.
In one example, the optoelectronic isolation circuit is further configured to perform optoelectronic isolation processing on a level signal sent by the external device, and transmit the level signal after the optoelectronic isolation processing to the controller;
and the controller is also used for identifying the running state of the external equipment according to the level signal.
The controller further includes an expansion interface, which is capable of expanding and connecting external devices, for example, the external devices include a foot switch, an electrocardiograph monitor, and the like, so that the controller realizes unified monitoring of the devices in the expansion connection. For example, the foot switch feeds back a level signal to the controller through the photoelectric isolation circuit, the controller identifies the open state, the closed state and the like of the foot switch according to the level signal, and if the open state is identified, the power supply system is controlled to supply power to the high-voltage electric pulse tumor therapeutic apparatus and start to work; if the high-voltage electric pulse tumor therapeutic apparatus is in the off state, the power supply system is controlled to stop supplying power to the high-voltage electric pulse tumor therapeutic apparatus, and the high-voltage electric pulse tumor therapeutic apparatus stops working.
In one example, the optoelectronic isolation circuit is further configured to perform optoelectronic isolation processing on a signal sent by the controller, and transmit the signal after the optoelectronic isolation processing to the external computer device.
It should be noted that the external computer device may be an input end through which a user inputs an instruction to the controller, and may also receive a signal transmitted by the controller, so that there is signal interaction between the external computer device and the controller.
In order to improve the interference immunity of various types of signal transmission, referring to fig. 4, the control circuit 31 further includes a Buffer module 317; the Buffer module 317 is electrically connected to the controller 311, the signal output circuit 313 and the optoelectronic isolation circuit 315, respectively. It should be noted that, signals of interaction between the controller and the optoelectronic isolation circuit, and signals of the signal output circuit and the optoelectronic isolation circuit all need to be amplified by the Buffer module, so that the anti-interference performance of signal transmission is improved.
In order to isolate various types of signals and realize parallel transmission, in one embodiment, the photoelectric isolation circuit comprises:
the first linear optical coupler isolator is used for carrying out photoelectric isolation processing on the PWM wave control signal sent by the controller, and transmitting the PWM wave control signal after the photoelectric isolation processing to a power supply system of the high-voltage electric pulse tumor therapeutic apparatus;
the linear optical coupler isolator string is used for carrying out photoelectric isolation processing on an analog signal sent by the pulse equipment and transmitting the analog signal subjected to the photoelectric isolation processing to the controller so that the controller can identify the running state of the pulse equipment according to the analog signal; the linear optocoupler isolator string comprises a second linear optocoupler isolator and a third linear optocoupler isolator connected with the second linear optocoupler isolator;
the optical fiber isolator is used for carrying out photoelectric isolation processing on the pulse signal sent by the signal output circuit and transmitting the pulse signal after the photoelectric isolation processing to the pulse measurement and control circuit; the charging control circuit is also used for carrying out photoelectric isolation processing on the charging control signal sent by the controller and transmitting the charging control signal subjected to the photoelectric isolation processing to the charging measurement and control circuit; the controller is also used for carrying out photoelectric isolation processing on the discharge control signal sent by the controller and transmitting the discharge control signal subjected to the photoelectric isolation processing to the discharge measurement and control circuit;
the optical coupler isolator is used for realizing the photoelectric isolation transmission of signals between the controller and external computer equipment; and the controller is also used for carrying out photoelectric isolation processing on the level signal sent by the external equipment and transmitting the level signal after the photoelectric isolation processing to the controller.
In each embodiment of the pulse output device, the charging part, the pulse generating part and the discharging part are independently arranged into plates, and related circuits on the charging plate, the pulse generating plate and the discharging plate are arranged in an isolated mode, so that the electrical isolation effect of pulse equipment is increased, the output pulse quality is improved, an interference propagation path of a signal is isolated, the anti-interference performance of the signal is enhanced, the accuracy of signal transmission is improved, and the output pulse quality is improved.
In one embodiment, referring to fig. 5, there is provided a high voltage electric pulse tumor therapeutic apparatus comprising the pulse output device; the RFID card reader also comprises a needle track panel 51 and an RFID detection module 53 connected with the needle track panel 51;
the needle track panel 51 is connected with the discharge circuit 151; the RFID detection module 53 is connected to the optoelectronic isolation circuit 315.
It should be noted that the needle track panel includes a plurality of pairs of discharge needles, and the discharge needles can be selected by the control board according to actual requirements.
In one example, referring to fig. 6, the high voltage electric pulse oncology therapy apparatus further comprises an external computer device 61, a foot switch 63, and an electrocardiograph 65; the external computer device 61, the foot switch 63 and the electrocardiograph 65 are respectively connected with the photoelectric isolation circuit 315. Specifically, the external computer equipment, the foot switch and the electrocardioscanner are respectively connected with the controller through the photoelectric isolation circuit and the Buffer module. It should be noted that, the functions of the external computer device, the foot switch, and the electrocardiograph monitor, and the signal transmission modes between the external computer device, the foot switch, the electrocardiograph monitor, and the control circuit, etc. please refer to the description in each embodiment of the control circuit of this application, and the description is omitted here.
In another example, referring to fig. 7, the high voltage electric pulse tumor treatment apparatus further comprises a power control circuit 71, a power system 73; the power supply control circuit 71 is connected to the external computer device 61 and the power supply system 73, respectively; the power supply system 73 is connected to the photoelectric isolation circuit 315 and the charging circuit 111, respectively. Specifically, the power supply system is connected with the controller through the photoelectric isolation circuit.
In another example, the high-voltage electric pulse tumor therapeutic apparatus further comprises a temperature detection device, wherein the temperature detection device is connected with the photoelectric isolation circuit and used for monitoring the temperature of the discharge area of the needle track panel and feeding back the temperature to the controller through the photoelectric isolation circuit, and the controller controls the discharge circuit to stop discharging when the temperature exceeds a preset threshold value. Specifically, the temperature detection device is connected with the controller through the photoelectric isolation circuit and the Buffer module.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the claims. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
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