CN112336907A - 一种止血修复用生物活性玻璃材料及其制备方法 - Google Patents
一种止血修复用生物活性玻璃材料及其制备方法 Download PDFInfo
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Abstract
本发明属于生物活性玻璃技术领域，尤其为一种止血修复用生物活性玻璃材料及其制备方法，一种止血修复用生物活性玻璃材料，原料由竹原纤维、海藻酸钠、透明质酸钠、硬质酸、壳聚糖、生物活性玻璃、抗菌剂和二甲基硅油构成。本发明通过添加竹原纤维、海藻酸钠、透明质酸钠、壳聚糖、硬脂酸和生物活性玻璃的使用，使得该生物活性玻璃材料具有良好的润滑、保湿、较高抑菌作用、止血效果显著、能够促进伤口愈合并且使用舒适便捷的功效型，通过二甲基硅油和抗菌剂的使用，使得该生物活性玻璃材料拥有很高的抗剪能力，避免玻璃中气泡的产生，无毒无害，同时也减少了抗生素、银离子等的使用量，具有很好的生物安全性，不会对人体产生损害。
Description
技术领域
本发明涉及生物活性玻璃技术领域，具体为一种止血修复用生物活性玻璃材料及其制备方法。
背景技术
玻璃是非晶无机非金属材料，一般是用多种无机矿物(如石英砂、硼砂、硼酸、重晶石、碳酸钡、石灰石、长石、纯碱等)为主要原料，另外加入少量辅助原料制成的。它的主要成分为二氧化硅和其他氧化物，同样生物活性玻璃的制造过程与常规玻璃的制造步骤大体相同，生物活性玻璃是一类能对机体组织进行修复、替代与再生、具有能使组织和材料之间形成键合作用的材料。BAG在1969年由Hench发现，由SiO2，Na2O，CaO和P2O5等基本成分组成的硅酸盐玻璃。生物活性玻璃的降解产物能够促进生长因子的生成、促进细胞的繁衍、增强成骨细胞的基因表达和骨组织的生长。是迄今为止唯一既能够与骨组织成键结合，同时又能与软组织相连接的人工生物材料。
但是现有的生物活性玻璃材料存在以下问题：
1、现有的生物活性玻璃材料在使用三到五天左右会出现腐败恶臭现象，必须专门单独使用杀菌剂处理患处，很难具备抑菌性能，从而降低了该生物活性玻璃材料的实用性；
2、由于该生物活性玻璃材料使用材质比较单一，在皮肤创面愈合过程中，存在愈合速度慢、易感染、疤痕增生和止血效果不理想等问题，很难满足皮肤创面快速愈合的要求。
发明内容
(一)解决的技术问题
针对现有技术的不足，本发明提供了一种止血修复用生物活性玻璃材料及其制备方法，解决了现有的生物活性玻璃材料抑菌性能较差和止血效果不理想的问题。
(二)技术方案
为实现上述目的，本发明提供如下技术方案：一种止血修复用生物活性玻璃材料，原料由竹原纤维、海藻酸钠、透明质酸钠、硬质酸、壳聚糖、生物活性玻璃、抗菌剂和二甲基硅油构成，各组分按重量份数计：竹原纤维60-90 份、海藻酸钠1-5份、透明质酸钠0.1-0.3份、硬质酸25-30份、壳聚糖6-10 份、生物活性玻璃4-8份、抗菌剂1-2份和二甲基硅油0.5-1.5份。
作为本发明的一种优选技术方案，生物活性玻璃包括以下重量份数：45～ 50％的SiO2、4～6％的P2O5、20～25％的Na2O和25～35％的CaO，各组分的含量之和为100％。
作为本发明的一种优选技术方案，生物活性玻璃的粒径为25～35μm。
作为本发明的一种优选技术方案，壳聚糖为壳聚糖碘、壳聚糖季铵盐或羧甲基壳聚糖中的任一种。
一种止血修复用生物活性玻璃材料的制备方法，包括以下步骤：
步骤S1、首先将海藻酸钠和透明质酸钠溶解于去离子水中，在25℃条件下进行搅拌和混合，使得海藻酸钠和透明质酸钠全部溶解，得到混合液A；
步骤S2、将步骤S1中的混合液A依次加入硬质酸、壳聚糖、生物活性玻璃、抗菌剂和二甲基硅油，进行搅拌混合，得到纺丝原液B；
步骤S3、将步骤S2中的纺丝原液B，以氯化钙溶液为凝固浴，经静电纺丝工艺处理，得到功能纤维C；
步骤S4、最后将竹原纤维和步骤S3得到的功能纤维C经开松、共混、梳理、铺网、针刺、整烫、收卷，最后剪切、包装、灭菌，得到生物活性玻璃材料。
作为本发明的一种优选技术方案，步骤S3中氯化钙溶液的质量浓度为 1.0％。
作为本发明的一种优选技术方案，步骤S1中去离子水的质量比为1:20～ 1:100。
作为本发明的一种优选技术方案，步骤S2中得到的纺丝原液B，加入1-10 份数的氨水，调节混合溶液的PH值至8-9。
(三)有益效果
与现有技术相比，本发明提供了一种止血修复用生物活性玻璃材料及其制备方法，具备以下有益效果：
该止血修复用生物活性玻璃材料及其制备方法，通过添加竹原纤维、海藻酸钠、透明质酸钠、壳聚糖、硬脂酸和生物活性玻璃的使用，使得该生物活性玻璃材料具有良好的润滑、保湿、较高抑菌作用、止血效果显著、能够促进伤口愈合并且使用舒适便捷的功效型，通过二甲基硅油和抗菌剂的使用，使得该生物活性玻璃材料拥有很高的抗剪能力，避免玻璃中气泡的产生，无毒无害，同时也减少了抗生素、银离子等的使用量，具有很好的生物安全性，无细胞毒性，无皮肤刺激，不会对人体产生损害。
附图说明
图1为本发明一种止血修复用生物活性玻璃材料及其制备方法流程图。
具体实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
请参阅图1，本发明提供以下技术方案：一种止血修复用生物活性玻璃材料，原料由竹原纤维、海藻酸钠、透明质酸钠、硬质酸、壳聚糖、生物活性玻璃、抗菌剂和二甲基硅油构成，各组分按重量份数计：竹原纤维60份、海藻酸钠1份、透明质酸钠0.1份、硬质酸25份、壳聚糖6份、生物活性玻璃 4份、抗菌剂1份和二甲基硅油0.5份。
具体的，生物活性玻璃包括以下重量份数：45％的SiO2、5％的P2O5、20％的Na2O和30％的CaO，各组分的含量之和为100％。
具体的，生物活性玻璃的粒径为25μm。
具体的，壳聚糖为壳聚糖碘。
一种止血修复用生物活性玻璃材料的制备方法，包括以下步骤：
步骤S1、首先将海藻酸钠和透明质酸钠溶解于去离子水中，在25℃条件下进行搅拌和混合，使得海藻酸钠和透明质酸钠全部溶解，得到混合液A；
步骤S2、将步骤S1中的混合液A依次加入硬质酸、壳聚糖、生物活性玻璃、抗菌剂和二甲基硅油，进行搅拌混合，得到纺丝原液B；
步骤S3、将步骤S2中的纺丝原液B，以氯化钙溶液为凝固浴，经静电纺丝工艺处理，得到功能纤维C；
步骤S4、最后将竹原纤维和步骤S3得到的功能纤维C经开松、共混、梳理、铺网、针刺、整烫、收卷，最后剪切、包装、灭菌，得到生物活性玻璃材料。
具体的，步骤S3中氯化钙溶液的质量浓度为1.0％。
具体的，步骤S1中去离子水的质量比为1:20～1:100。
具体的，步骤S2中得到的纺丝原液B，加入4份数的氨水，调节混合溶液的PH值至8。
实施例2
请参阅图1，本发明提供以下技术方案：一种止血修复用生物活性玻璃材料，原料由竹原纤维、海藻酸钠、透明质酸钠、硬质酸、壳聚糖、生物活性玻璃、抗菌剂和二甲基硅油构成，各组分按重量份数计：竹原纤维80份、海藻酸钠3份、透明质酸钠0.2份、硬质酸28份、壳聚糖8份、生物活性玻璃6份、抗菌剂1.5份和二甲基硅油1份。
具体的，生物活性玻璃包括以下重量份数：46％的SiO2、4％的P2O5、22％的Na2O和28％的CaO，各组分的含量之和为100％。
具体的，生物活性玻璃的粒径为30μm。
具体的，壳聚糖为壳聚糖碘、壳聚糖季铵盐或羧甲基壳聚糖中的任一种。
一种止血修复用生物活性玻璃材料的制备方法，包括以下步骤：
步骤S1、首先将海藻酸钠和透明质酸钠溶解于去离子水中，在25℃条件下进行搅拌和混合，使得海藻酸钠和透明质酸钠全部溶解，得到混合液A；
步骤S2、将步骤S1中的混合液A依次加入硬质酸、壳聚糖、生物活性玻璃、抗菌剂和二甲基硅油，进行搅拌混合，得到纺丝原液B；
步骤S3、将步骤S2中的纺丝原液B，以氯化钙溶液为凝固浴，经静电纺丝工艺处理，得到功能纤维C；
步骤S4、最后将竹原纤维和步骤S3得到的功能纤维C经开松、共混、梳理、铺网、针刺、整烫、收卷，最后剪切、包装、灭菌，得到生物活性玻璃材料。
具体的，步骤S3中氯化钙溶液的质量浓度为1.0％。
具体的，步骤S1中去离子水的质量比为1:20～1:100。
具体的，步骤S2中得到的纺丝原液B，加入8份数的氨水，调节混合溶液的PH值至8.5。
实施例3
请参阅图1，本发明提供以下技术方案：一种止血修复用生物活性玻璃材料，原料由竹原纤维、海藻酸钠、透明质酸钠、硬质酸、壳聚糖、生物活性玻璃、抗菌剂和二甲基硅油构成，各组分按重量份数计：竹原纤维90份、海藻酸钠5份、透明质酸钠0.3份、硬质酸30份、壳聚糖10份、生物活性玻璃8份、抗菌剂2份和二甲基硅油1.5份。
具体的，生物活性玻璃包括以下重量份数：48％的SiO2、6％的P2O5、23％的Na2O和23％的CaO，各组分的含量之和为100％。
具体的，生物活性玻璃的粒径为35μm。
具体的，壳聚糖为羧甲基壳聚糖。
一种止血修复用生物活性玻璃材料的制备方法，包括以下步骤：
步骤S1、首先将海藻酸钠和透明质酸钠溶解于去离子水中，在25℃条件下进行搅拌和混合，使得海藻酸钠和透明质酸钠全部溶解，得到混合液A；
步骤S2、将步骤S1中的混合液A依次加入硬质酸、壳聚糖、生物活性玻璃、抗菌剂和二甲基硅油，进行搅拌混合，得到纺丝原液B；
步骤S3、将步骤S2中的纺丝原液B，以氯化钙溶液为凝固浴，经静电纺丝工艺处理，得到功能纤维C；
步骤S4、最后将竹原纤维和步骤S3得到的功能纤维C经开松、共混、梳理、铺网、针刺、整烫、收卷，最后剪切、包装、灭菌，得到生物活性玻璃材料。
具体的，步骤S3中氯化钙溶液的质量浓度为1.0％。
具体的，步骤S1中去离子水的质量比为1:20～1:100。
具体的，步骤S2中得到的纺丝原液B，加入10份数的氨水，调节混合溶液的PH值至9。
由实施例1、2和3制备的生物活性玻璃材料，通过添加竹原纤维、海藻酸钠、透明质酸钠、壳聚糖、硬脂酸和生物活性玻璃的使用，使得该生物活性玻璃材料具有良好的润滑、保湿、较高抑菌作用、止血效果显著、能够促进伤口愈合并且使用舒适便捷的功效型，通过二甲基硅油和抗菌剂的使用，使得该生物活性玻璃材料拥有很高的抗剪能力，避免玻璃中气泡的产生，无毒无害，同时也减少了抗生素、银离子等的使用量，具有很好的生物安全性，无细胞毒性，无皮肤刺激，不会对人体产生损害。
最后应说明的是：以上所述仅为本发明的优选实施例而已，并不用于限制本发明，尽管参照前述实施例对本发明进行了详细的说明，对于本领域的技术人员来说，其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (8)
1.一种止血修复用生物活性玻璃材料，其特征在于：原料由竹原纤维、海藻酸钠、透明质酸钠、硬质酸、壳聚糖、生物活性玻璃、抗菌剂和二甲基硅油构成，各组分按重量份数计：竹原纤维60-90份、海藻酸钠1-5份、透明质酸钠0.1-0.3份、硬质酸25-30份、壳聚糖6-10份、生物活性玻璃4-8份、抗菌剂1-2份和二甲基硅油0.5-1.5份。
2.根据权利要求1所述的一种止血修复用生物活性玻璃材料，其特征在于：生物活性玻璃包括以下重量份数：45～50％的SiO2、4～6％的P2O5、20～25％的Na2O和25～35％的CaO，各组分的含量之和为100％。
3.根据权利要求1所述的一种止血修复用生物活性玻璃材料，其特征在于：生物活性玻璃的粒径为25～35μm。
4.根据权利要求1所述的一种止血修复用生物活性玻璃材料，其特征在于：壳聚糖为壳聚糖碘、壳聚糖季铵盐或羧甲基壳聚糖中的任一种。
5.根据权利要求1-4任一项所述的一种止血修复用生物活性玻璃材料的制备方法，其特征在于：包括以下步骤：
步骤S1、首先将海藻酸钠和透明质酸钠溶解于去离子水中，在25℃条件下进行搅拌和混合，使得海藻酸钠和透明质酸钠全部溶解，得到混合液A；
步骤S2、将步骤S1中的混合液A依次加入硬质酸、壳聚糖、生物活性玻璃、抗菌剂和二甲基硅油，进行搅拌混合，得到纺丝原液B；
步骤S3、将步骤S2中的纺丝原液B，以氯化钙溶液为凝固浴，经静电纺丝工艺处理，得到功能纤维C；
步骤S4、最后将竹原纤维和步骤S3得到的功能纤维C经开松、共混、梳理、铺网、针刺、整烫、收卷，最后剪切、包装、灭菌，得到生物活性玻璃材料。
6.根据权利要求5所述的一种止血修复用生物活性玻璃材料的制备方法，其特征在于：步骤S3中氯化钙溶液的质量浓度为1.0％。
7.根据权利要求5所述的一种止血修复用生物活性玻璃材料的制备方法，其特征在于：步骤S1中去离子水的质量比为1:20～1:100。
8.根据权利要求5所述的一种止血修复用生物活性玻璃材料的制备方法，其特征在于：步骤S2中得到的纺丝原液B，加入1-10份数的氨水，调节混合溶液的PH值至8-9。
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005084726A1 (en) * | 2004-03-08 | 2005-09-15 | Dr.H.C. Robert Mathys Stiftung | Hydraulic cement based on calcium phosphate for surgical use |
| CN105999365A (zh) * | 2016-07-26 | 2016-10-12 | 四川艾医生医疗科技有限公司 | 一种功效型鼻腔止血材料及其制备方法 |
| CN106377791A (zh) * | 2016-09-06 | 2017-02-08 | 广东泰宝医疗科技股份有限公司 | 一种竹原藻酸盐功能敷料及其制备方法 |
| CN107981967A (zh) * | 2016-10-26 | 2018-05-04 | 袁暾 | 一种载硅酸盐微粒的冷敷敷贴 |
| CN110368517A (zh) * | 2019-07-26 | 2019-10-25 | 深圳阳光环球玻璃有限公司 | 一种伤口止血修复用生物活性玻璃医用材料 |
| CN111529442A (zh) * | 2020-05-08 | 2020-08-14 | 紫水晶(山西)再生医学科技有限公司 | 一种用于医美的水光注射液及其制造方法 |
-
2020
- 2020-10-23 CN CN202011146750.1A patent/CN112336907A/zh active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005084726A1 (en) * | 2004-03-08 | 2005-09-15 | Dr.H.C. Robert Mathys Stiftung | Hydraulic cement based on calcium phosphate for surgical use |
| CN105999365A (zh) * | 2016-07-26 | 2016-10-12 | 四川艾医生医疗科技有限公司 | 一种功效型鼻腔止血材料及其制备方法 |
| CN106377791A (zh) * | 2016-09-06 | 2017-02-08 | 广东泰宝医疗科技股份有限公司 | 一种竹原藻酸盐功能敷料及其制备方法 |
| CN107981967A (zh) * | 2016-10-26 | 2018-05-04 | 袁暾 | 一种载硅酸盐微粒的冷敷敷贴 |
| CN110368517A (zh) * | 2019-07-26 | 2019-10-25 | 深圳阳光环球玻璃有限公司 | 一种伤口止血修复用生物活性玻璃医用材料 |
| CN111529442A (zh) * | 2020-05-08 | 2020-08-14 | 紫水晶(山西)再生医学科技有限公司 | 一种用于医美的水光注射液及其制造方法 |
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