CN112263510B - Preparation method of facial mask - Google Patents
Preparation method of facial mask Download PDFInfo
- Publication number
- CN112263510B CN112263510B CN202011108975.8A CN202011108975A CN112263510B CN 112263510 B CN112263510 B CN 112263510B CN 202011108975 A CN202011108975 A CN 202011108975A CN 112263510 B CN112263510 B CN 112263510B
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- China
- Prior art keywords
- pineapple peel
- peel residue
- wogonin
- mask
- cellulose
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- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- 230000001815 facial effect Effects 0.000 title claims description 38
- 241000234671 Ananas Species 0.000 claims abstract description 141
- 235000007119 Ananas comosus Nutrition 0.000 claims abstract description 141
- 239000001913 cellulose Substances 0.000 claims abstract description 101
- 229920002678 cellulose Polymers 0.000 claims abstract description 101
- HIMJIPRMECETLJ-UHFFFAOYSA-N Wogonin Natural products COc1cc(O)c(O)c2C(=O)C=C(Oc12)c3ccccc3 HIMJIPRMECETLJ-UHFFFAOYSA-N 0.000 claims abstract description 67
- XLTFNNCXVBYBSX-UHFFFAOYSA-N wogonin Chemical compound COC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=CC=C1 XLTFNNCXVBYBSX-UHFFFAOYSA-N 0.000 claims abstract description 67
- 150000001875 compounds Chemical class 0.000 claims abstract description 50
- 239000000835 fiber Substances 0.000 claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 102000003425 Tyrosinase Human genes 0.000 claims abstract description 27
- 108060008724 Tyrosinase Proteins 0.000 claims abstract description 27
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 24
- 238000001035 drying Methods 0.000 claims abstract description 23
- 239000004386 Erythritol Substances 0.000 claims abstract description 22
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims abstract description 22
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims abstract description 22
- 229940009714 erythritol Drugs 0.000 claims abstract description 22
- 235000019414 erythritol Nutrition 0.000 claims abstract description 22
- 230000005764 inhibitory process Effects 0.000 claims abstract description 22
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 21
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 16
- 238000005406 washing Methods 0.000 claims abstract description 16
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims abstract description 14
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 14
- 238000000605 extraction Methods 0.000 claims abstract description 13
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 12
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229960002216 methylparaben Drugs 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 11
- 229960003742 phenol Drugs 0.000 claims abstract description 11
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 claims abstract description 11
- 229960002218 sodium chlorite Drugs 0.000 claims abstract description 11
- 239000012153 distilled water Substances 0.000 claims abstract description 10
- 238000007710 freezing Methods 0.000 claims abstract description 10
- 230000008014 freezing Effects 0.000 claims abstract description 10
- 238000003756 stirring Methods 0.000 claims abstract description 9
- 238000004061 bleaching Methods 0.000 claims abstract description 8
- 238000007872 degassing Methods 0.000 claims abstract description 8
- 238000004140 cleaning Methods 0.000 claims abstract description 7
- 230000001954 sterilising effect Effects 0.000 claims description 13
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- 229960002897 heparin Drugs 0.000 claims description 10
- 229920000669 heparin Polymers 0.000 claims description 10
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000012986 modification Methods 0.000 claims description 6
- 230000004048 modification Effects 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 230000014759 maintenance of location Effects 0.000 abstract description 19
- 230000003647 oxidation Effects 0.000 abstract description 11
- 238000007254 oxidation reaction Methods 0.000 abstract description 11
- 239000000243 solution Substances 0.000 description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 32
- 230000000052 comparative effect Effects 0.000 description 23
- 210000003491 skin Anatomy 0.000 description 20
- 238000012360 testing method Methods 0.000 description 18
- 239000000523 sample Substances 0.000 description 12
- 235000019441 ethanol Nutrition 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 239000002608 ionic liquid Substances 0.000 description 9
- 239000011259 mixed solution Substances 0.000 description 9
- 239000000758 substrate Substances 0.000 description 9
- 239000002994 raw material Substances 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 238000001914 filtration Methods 0.000 description 7
- 150000008442 polyphenolic compounds Chemical class 0.000 description 7
- 235000013824 polyphenols Nutrition 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 6
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 6
- 230000003020 moisturizing effect Effects 0.000 description 6
- 239000008363 phosphate buffer Substances 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 5
- 238000004108 freeze drying Methods 0.000 description 5
- 230000007935 neutral effect Effects 0.000 description 5
- 239000012488 sample solution Substances 0.000 description 5
- 238000007873 sieving Methods 0.000 description 5
- 238000002791 soaking Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 241000700159 Rattus Species 0.000 description 4
- 206010040880 Skin irritation Diseases 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 239000004519 grease Substances 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 238000003760 magnetic stirring Methods 0.000 description 4
- 239000012046 mixed solvent Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 230000036556 skin irritation Effects 0.000 description 4
- 231100000475 skin irritation Toxicity 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- 230000002087 whitening effect Effects 0.000 description 4
- 238000000151 deposition Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 238000004537 pulping Methods 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 229960004441 tyrosine Drugs 0.000 description 3
- 229910021642 ultra pure water Inorganic materials 0.000 description 3
- 239000012498 ultrapure water Substances 0.000 description 3
- 241000629412 Ligustrum robustum Species 0.000 description 2
- 239000005708 Sodium hypochlorite Substances 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 238000001878 scanning electron micrograph Methods 0.000 description 2
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- -1 1-allyl-3-methylimidazole chloride salt Chemical class 0.000 description 1
- PBIDWHVVZCGMAR-UHFFFAOYSA-N 1-methyl-3-prop-2-enyl-2h-imidazole Chemical compound CN1CN(CC=C)C=C1 PBIDWHVVZCGMAR-UHFFFAOYSA-N 0.000 description 1
- 244000298800 Actinidia arguta Species 0.000 description 1
- 235000016416 Actinidia arguta Nutrition 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 235000003332 Ilex aquifolium Nutrition 0.000 description 1
- 235000002296 Ilex sandwicensis Nutrition 0.000 description 1
- 235000002294 Ilex volkensiana Nutrition 0.000 description 1
- 241000221638 Morchella Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a preparation method of a mask; the method comprises the following steps: mixing wogonin/pineapple peel residue cellulose compound, bitter Ding Chaduo phenol, erythritol and methyl parahydroxybenzoate, pouring into a mold, cleaning, autoclaving, and freezing; the preparation method of the wogonin/pineapple peel residue cellulose compound comprises the following steps: pretreating pineapple peel residues to obtain pineapple peel residue crude fibers A; step-by-step extraction of the pineapple peel residue fibers by distilled water and sodium hydroxide to obtain pineapple peel residue fibers B; heat-treating the pineapple peel residue with sodium chlorite solution, washing and drying to obtain pineapple peel residue fiber C; then, bleaching the pineapple peel residue cellulose by alkaline hydrogen peroxide to obtain pineapple peel residue cellulose; dissolving pineapple peel residue cellulose in acetic acid solution, adding wogonin, stirring uniformly, ultrasonically degassing, and drying; the prepared mask has good oxidation resistance, safety, water retention, heat resistance and cold resistance, and high tyrosinase inhibition rate and moisture retention rate.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a preparation method of a mask.
Background
Today, the life quality of people is gradually improved, and the demands for the facial mask are also increasing. A large number of enterprises produce various mask products, and the most basic is quality and safety problems, so that safety and environmental protection are future development trends of the mask market. Aiming at the current form of the mask market, the natural product is utilized to manufacture the mask, which is the important point of the development of the mask industry.
The facial mask is a product with efficacy in skin care products, and the principle is that the skin mask is temporarily isolated from the outside air by using the short time covered on the face, and pores indicated by the skin can be opened while the temperature of the skin is increased, so that sweat gland secretion and metabolism can be promoted, the oxygen content of the skin is increased, the skin is facilitated to remove the products of metabolism of epidermal cells and accumulated grease substances, and moisture in the facial mask can permeate into the stratum corneum of the epidermis, so that the skin becomes soft, and the skin is natural, bright and elastic.
A large number of enterprises produce different facial mask products, and the most basic are quality and safety, namely: the problem of whether or not the product contains a irritating chemical component and is harmful to the skin is the biggest problem when the consumer purchases the product. Many researchers extract functional active substances from natural substances as raw materials to make masks. Kang Zhenyu (development of a novel natural facial mask and functional research thereof, shenyang agricultural university, 2019) is prepared by taking actinidia arguta pectin, morchella fermentation broth and beer yeast muddy water solution as raw materials and mixing according to different proportions. The natural facial mask liquid has good antioxidant, antibacterial, moisturizing and whitening effects.
Disclosure of Invention
The invention aims to provide a facial mask with good oxidation resistance, safety, water retention, heat resistance and cold resistance and high tyrosinase inhibition rate and moisture retention rate.
The technical scheme adopted by the invention for achieving the purpose is as follows:
a method for preparing a facial mask, which comprises the following steps: mixing wogonin/pineapple peel residue cellulose compound, bitter Ding Chaduo phenol, erythritol and methyl parahydroxybenzoate, pouring into a mold, cleaning, autoclaving, and freezing to obtain facial mask.
The invention adopts wogonin/pineapple peel residue cellulose compound, bitter Ding Chaduo phenol, erythritol and methyl parahydroxybenzoate as raw materials, and the prepared mask has good oxidation resistance, high tyrosinase inhibition rate, high safety, high moisture retention rate, high antibacterial property and good heat resistance and cold resistance. The reason is probably that the wogonin/pineapple peel residue cellulose compound can form a larger network structure, so that the bitter Ding Chaduo phenol, the erythritol and the methyl p-hydroxybenzoate are fixed in the internal structure of the wogonin/pineapple peel residue cellulose compound by utilizing the double effects of physical adsorption or hydrogen bond coupling, and the essence contained in each component enables the mask to better adhere to the skin, so that excessive grease in the skin is absorbed in a large amount, and the purposes of moisture retention and purification are achieved; meanwhile, the interaction of the components has better inhibition effect on tyrosinase, prevents melanin from depositing, and achieves the effects of whitening, moisturizing and resisting oxidation; in addition, the facial mask does not contain substances which are irritating to skin, has good safety and has good physicochemical properties such as heat resistance, cold resistance and the like.
Preferably, the wogonin/pineapple peel residue cellulose compound is 15-30 parts, the bitter Ding Chaduo phenol is 5-9 parts, the erythritol is 7-12 parts, and the methyl parahydroxybenzoate is 1-4 parts by weight.
Preferably, the autoclaving temperature is 105-115 ℃ and the sterilization time is 25-35 min.
Preferably, the freezing conditions are: freezing at-25 to-15 ℃ for 20-22 h.
Preferably, the preparation steps of the wogonin/pineapple peel residue cellulose compound are as follows:
pretreating pineapple peel residues to obtain pineapple peel residue crude fibers A;
step-by-step extraction of the pineapple peel residue crude fiber A by distilled water and sodium hydroxide to obtain pineapple peel residue fiber B;
performing heat treatment on the pineapple peel residue fiber B through sodium chlorite solution, washing and drying to obtain pineapple peel residue fiber C;
bleaching the pineapple peel residue fiber C by alkaline hydrogen peroxide at 65-75 ℃ to obtain pineapple peel residue cellulose;
dissolving the pineapple peel residue cellulose in acetic acid solution, then adding wogonin, stirring uniformly, performing ultrasonic degassing, and drying to obtain a wogonin/pineapple peel residue cellulose compound.
Preferably, the solid-liquid density ratio of the step extraction is 1:15-20, the treatment temperature is 60-70 ℃, and the treatment time is 1.5-2.5 h.
Preferably, the sodium chlorite solution is adjusted to a pH of 3.85-4.05 with hydrochloric acid.
Preferably, the heat treatment temperature is 65-75 ℃ and the time is 1-1.5 h, and the pineapple peel residue fiber C is fully extracted.
Preferably, the pineapple peel residue cellulose is 1 to 6 parts by weight and the wogonin is 0.02 to 0.08 part by weight.
Preferably, the degassing time is 6-10 min, the drying temperature is 55-65 ℃ and the drying time is 5-7 h.
Preferably, the preparation method of the kuding tea polyphenol comprises the following steps:
pulverizing Folum Ilicis with pulverizer, sieving to obtain 50-80 mesh Folum Ilicis powder, weighing 65-85 parts by weight of Folum Ilicis powder, placing into volumetric flask, adding 25-75% ethanol solution, reacting at 45-75W ultrasonic power for 0.5-2.5 hr and at 25-45deg.C to obtain extractive solution, centrifuging at 8000-9000 r/min for 6-9 min, collecting supernatant, pre-cooling, and lyophilizing to constant weight, wherein the extraction rate of Folum Ilicis polyphenol is 1.75-3.12%.
Preferably, the inhibition rate of tyrosinase of the mask is not lower than 92%.
In order to further improve the oxidation resistance, tyrosinase inhibition rate, water retention and moisture retention of the mask, the preferred measures adopted further comprise:
performing grafting modification on pineapple peel residue cellulose by heparin to obtain modified pineapple peel residue cellulose, and reacting with wogonin to obtain a wogonin/modified pineapple peel residue cellulose compound; the pineapple peel residue cellulose can activate the groups of cellulose in ionic liquid, so that the pineapple peel residue cellulose fully reacts with heparin to obtain modified pineapple peel residue cellulose with good performance, and then reacts with wogonin to obtain a wogonin/modified pineapple peel residue cellulose compound; the compound is used as a component of the facial mask, and interacts with other components, so that the oxidation resistance, tyrosinase inhibition rate, water retention and moisture retention of the facial mask are further improved.
Preferably, the preparation method of the modified pineapple peel residue cellulose comprises the following steps:
adding pineapple peel cellulose into a mixed solvent for dewaxing for 4.5-5.5 hours, wherein the volume ratio of toluene to absolute ethyl alcohol in the mixed solvent is 1-2:1, adding sodium hypochlorite with the pH value of 3.85-4.05 for bleaching, the reaction temperature is 55-70 ℃, putting into a sodium hydroxide solution with the concentration of 8-10% for soaking for 7-9 hours, filtering, rinsing to be neutral by distilled water, washing by using 95% of ethyl alcohol, and freeze-drying;
heating the ionic liquid of the 1-allyl-3-methylimidazole chloride to 65-75 ℃, adding the dried pineapple peel cellulose into the ionic liquid, removing water vapor under the action of magnetic stirring, fully mixing the pineapple peel cellulose with the ionic liquid, and preserving the temperature for 100-115 min; and then adding heparin, wherein the weight ratio of the heparin to the pineapple peel cellulose is 0.005-0.01:1, removing water vapor under the action of magnetic stirring, preserving heat at 65-80 ℃ for 75-95 min, adding absolute ethyl alcohol to terminate the reaction after the reaction is finished, filtering, adding sufficient distilled water to dissolve ionic liquid, washing a sample, and freeze-drying to obtain the modified pineapple peel cellulose.
The invention adopts the wogonin/pineapple peel residue cellulose compound, the bitter Ding Chaduo phenol, the erythritol and the methyl parahydroxybenzoate as raw materials to prepare the facial mask, so the facial mask has the following beneficial effects: the wogonin/pineapple peel residue cellulose compound may have a larger network structure, so that the bitter Ding Chaduo phenol, erythritol and methyl parahydroxybenzoate are fixed in the internal structure of the wogonin/pineapple peel residue cellulose compound by physical adsorption or hydrogen bond coupling dual action, and a large amount of redundant grease in the skin is absorbed, so that the purposes of moisture retention and water purification are achieved; meanwhile, the interaction of the components has better inhibition effect on tyrosinase, so as to achieve the effects of whitening, moisturizing and antioxidation; in addition, the facial mask does not contain substances which are irritating to skin, has good safety and has good physicochemical properties such as heat resistance, cold resistance and the like. Therefore, the facial mask provided by the invention has good oxidation resistance, safety, water retention, heat resistance and cold resistance, and high tyrosinase inhibition rate and moisture retention rate.
Drawings
FIG. 1 is an SEM image of the surface of a mask in example 2;
FIG. 2 is a graph of the water holding capacity of the mask;
FIG. 3 is a graph showing the moisture retention of the mask;
FIG. 4 shows DPPH removal rate of mask;
FIG. 5 shows tyrosinase inhibition rate of the mask.
Detailed Description
The technical scheme of the invention is further described in detail below with reference to the specific embodiments and the attached drawings:
meanwhile, the experimental methods described in the following examples are all conventional methods unless otherwise specified; the reagents and materials, unless otherwise specified, are commercially available.
In the examples, the preparation method of kuding tea polyphenol comprises the following steps:
pulverizing Folum Ilicis with pulverizer, sieving to obtain 60 mesh Folum Ilicis powder, weighing 70 parts by weight of Folum Ilicis powder, placing in volumetric flask, adding 50% ethanol solution with a volume fraction of 1:20, reacting at 60W ultrasonic power for 1.5 hr at 35 deg.C to obtain extractive solution, centrifuging at 8500r/min for 8min, collecting supernatant, pre-cooling, and drying in freeze dryer to constant weight, wherein the extraction rate of Folum Ilicis polyphenol is 1.86%.
Example 1
A method for preparing a facial mask, which comprises the following steps:
(1) Preparation of wogonin/pineapple peel residue cellulose compound
Washing, pulping and washing pineapple peel residues to remove soluble sugar, filtering, drying and crushing in a 55 ℃ oven, sieving with a 40-mesh sieve to obtain pineapple peel residue crude fiber A, and placing in a drying oven for standby; step-by-step extraction of pineapple peel residue crude fiber A by distilled water and 5% sodium hydroxide, wherein the solid-liquid density ratio of step-by-step extraction is 1:15, the treatment temperature is 65 ℃ and the treatment time is 2 hours, so as to obtain pineapple peel residue fiber B; heat-treating pineapple peel residue fiber B by sodium chlorite solution, regulating the pH of the sodium chlorite solution to 3.85 by hydrochloric acid, heat-treating at 65 ℃ for 1h, washing, and drying to obtain pineapple peel residue fiber C; bleaching pineapple peel residue fiber C by alkaline hydrogen peroxide at 70 ℃ to obtain pineapple peel residue cellulose; dissolving 5 parts by weight of pineapple peel residue cellulose in an acetic acid solution, adding 0.025 part by weight of wogonin, stirring uniformly, degassing in an ultrasonic cleaner for 8min, and drying in a 60 ℃ oven for 5.5h to obtain a wogonin/pineapple peel residue cellulose compound.
(2) Preparation of facial mask
According to parts by weight, 18 parts of wogonin/pineapple peel residue cellulose compound, 7 parts of broadleaf holly leaf polyphenol and 10 parts of erythritol are placed in a beaker, then 2.5 parts of methyl parahydroxybenzoate is added to 100mL, and the mixture is stirred magnetically at 80 ℃ and uniformly mixed to obtain a mixed solution; soaking the mask die in 75% ethanol solution for 30min, then performing ultraviolet sterilization for 30min, and placing in a constant temperature incubator; pouring the mixed solution into a mask mold, standing for 1.5h, taking out, and repeatedly cleaning with ultrapure water until the mixed solution is neutral to obtain a mask substrate; packaging the mask substrate by plastic package, sterilizing at high temperature of 110deg.C for 30min; and then freezing the mask substrate at the temperature of minus 25 ℃ for 20 hours to obtain the mask.
Example 2
A method for preparing a facial mask, which comprises the following steps:
(1) Preparation of wogonin/pineapple peel residue cellulose compound
Washing, pulping and washing pineapple peel residues to remove soluble sugar, filtering, drying and crushing in a 55 ℃ oven, sieving with a 40-mesh sieve to obtain pineapple peel residue crude fiber A, and placing in a drying oven for standby; step-by-step extraction of pineapple peel residue crude fiber A by distilled water and 5% sodium hydroxide, wherein the solid-liquid density ratio of step-by-step extraction is 1:18, the treatment temperature is 70 ℃, and the treatment time is 1.5h, so as to obtain pineapple peel residue fiber B; heat-treating pineapple peel residue fiber B by sodium chlorite solution, regulating the pH of the sodium chlorite solution to 3.92 by hydrochloric acid, heat-treating at 70 ℃ for 1.5h, washing and drying to obtain pineapple peel residue fiber C; bleaching pineapple peel residue fiber C by alkaline hydrogen peroxide at 70 ℃ to obtain pineapple peel residue cellulose; dissolving 3.5 parts by weight of pineapple peel residue cellulose in acetic acid solution, then adding 0.032 parts by weight of wogonin, uniformly stirring, degassing in an ultrasonic cleaner for 7.5min, and drying in a 55 ℃ oven for 6h to obtain a wogonin/pineapple peel residue cellulose compound.
(2) Preparation of facial mask
According to parts by weight, placing 20 parts by weight of wogonin/pineapple peel residue cellulose compound, 8 parts by weight of kudingcha polyphenol and 8.5 parts by weight of erythritol into a beaker, then adding 1.5 parts by weight of methyl parahydroxybenzoate into 100mL, magnetically stirring at 80 ℃ and uniformly mixing to obtain a mixed solution; soaking the mask die in 75% ethanol solution for 30min, then performing ultraviolet sterilization for 30min, and placing in a constant temperature incubator; pouring the mixed solution into a mask mold, standing for 1.5h, taking out, and repeatedly cleaning with ultrapure water until the mixed solution is neutral to obtain a mask substrate; packaging the mask substrate by plastic package, sterilizing at high temperature, wherein the high-pressure sterilization temperature is 108 ℃, and the sterilization time is 27min; and then freezing the mask substrate at the temperature of minus 20 ℃ for 21 hours to obtain the mask.
Example 3
A method for preparing a facial mask, which comprises the following steps:
(1) Preparation of wogonin/pineapple peel residue cellulose compound
Washing, pulping and washing pineapple peel residues to remove soluble sugar, filtering, drying and crushing in a 55 ℃ oven, sieving with a 40-mesh sieve to obtain pineapple peel residue crude fiber A, and placing in a drying oven for standby; step-by-step extraction of pineapple peel residue crude fiber A by distilled water and 5% sodium hydroxide, wherein the solid-liquid density ratio of step-by-step extraction is 1:20, the treatment temperature is 70 ℃, and the treatment time is 2.5h, so as to obtain pineapple peel residue fiber B; heat-treating pineapple peel residue fiber B by sodium chlorite solution, regulating the pH of the sodium chlorite solution to 4 by hydrochloric acid, heat-treating at 75 ℃ for 1.5h, washing, and drying to obtain pineapple peel residue fiber C; bleaching pineapple peel residue fiber C by alkaline hydrogen peroxide at 70 ℃ to obtain pineapple peel residue cellulose; dissolving 4.3 parts by weight of pineapple peel residue cellulose in an acetic acid solution, adding 0.055 parts by weight of wogonin, uniformly stirring, degassing in an ultrasonic cleaner for 10min, and drying in a 58 ℃ oven for 7h to obtain a wogonin/pineapple peel residue cellulose compound.
(2) Preparation of facial mask
According to parts by weight, placing 24 parts by weight of wogonin/pineapple peel residue cellulose compound, 6.5 parts by weight of kudingcha polyphenol and 11 parts by weight of erythritol into a beaker, then adding 3.5 parts by weight of methyl parahydroxybenzoate into 100mL, magnetically stirring at 80 ℃ and uniformly mixing to obtain a mixed solution; soaking the mask die in 75% ethanol solution for 30min, then performing ultraviolet sterilization for 30min, and placing in a constant temperature incubator; pouring the mixed solution into a mask mold, standing for 1.5h, taking out, and repeatedly cleaning with ultrapure water until the mixed solution is neutral to obtain a mask substrate; packaging the mask substrate by plastic package, sterilizing at high temperature, wherein the sterilizing temperature is 115 ℃ and the sterilizing time is 32min; and then freezing the mask substrate at the temperature of-15 ℃ for 22 hours to obtain the mask.
Examples 4 to 5
The preparation method of the mask comprises the same steps as in example 2 in other examples 4-5, wherein the difference of the weight parts of wogonin and pineapple peel residue cellulose in step (1) is shown in the table 1.
TABLE 1 wogonin and pineapple peel residue cellulose weight parts
| Examples | Wogonin | Pineapple peel residue cellulose |
| 2 | 0.032 part by weight | 3.5 parts by weight |
| 4 | 0.055 part by weight | 4.2 parts by weight |
| 5 | 0.075 part by weight | 6 parts by weight |
Examples 6 to 7
The preparation method of the mask is the same as in example 2 in other steps of examples 6-7, and the difference of the mask in the step (2) is shown in Table 2.
TABLE 2 mask having different weight portions of each component
| Examples | Wogonin/pineapple peel residue cellulose compound | Bitter Ding Chaduo phenol | Erythritol | P-hydroxybenzoic acid methyl ester |
| 2 | 20 parts by weight | 8 parts by weight | 8.5 parts by weight | 1.5 parts by weight |
| 6 | 26 parts by weight | 5.5 parts by weight | 7.5 parts by weight | 2.4 parts by weight |
| 7 | 30 parts by weight | 6.4 parts by weight | 10 parts by weight | 3.6 parts by weight |
Example 8
In order to further improve the oxidation resistance, tyrosinase inhibition rate, water retention and moisture retention of the mask, the preparation method of the mask comprises the following steps of:
(1) Preparation of wogonin/modified pineapple peel residue cellulose compound
Adding pineapple peel cellulose into a mixed solvent for dewaxing for 5 hours, wherein the volume ratio of toluene to absolute ethyl alcohol in the mixed solvent is 1:1, adding sodium hypochlorite with the pH value of 3.95 for bleaching, the reaction temperature is 65 ℃, adding 10% sodium hydroxide solution for soaking for 8 hours, filtering, rinsing with distilled water to be neutral, washing with 95% ethyl alcohol, and freeze-drying;
heating the ionic liquid of the 1-allyl-3-methylimidazole chloride salt to 75 ℃, adding the dried pineapple peel cellulose into the ionic liquid, removing water vapor under the action of magnetic stirring, fully mixing the pineapple peel cellulose with the ionic liquid, and preserving the heat for 110min; then adding heparin, wherein the weight ratio of heparin to pineapple peel cellulose is 0.007:1, removing water vapor under the action of magnetic stirring, preserving heat at 70 ℃ for 80min, adding absolute ethyl alcohol to terminate the reaction after the reaction is finished, filtering, adding sufficient distilled water, dissolving ionic liquid, cleaning a sample, and freeze-drying to obtain modified pineapple peel cellulose;
dissolving 3.5 parts by weight of modified pineapple peel residue cellulose in acetic acid solution, then adding 0.032 parts by weight of wogonin, uniformly stirring, degassing in an ultrasonic cleaner for 7.5min, and drying in a 55 ℃ oven for 6h to obtain a wogonin/modified pineapple peel residue cellulose compound.
Step (2) is the same as in example 2.
Examples 9 to 10
The preparation method of the mask is the same as in example 8 in other steps of examples 9 to 10, except that in step (1), the weight ratio of heparin to pineapple peel cellulose in the process of preparing modified pineapple peel cellulose is different from that of example 8, and the specific differences are shown in Table 3.
Table 3 weight ratio of heparin to pineapple peel cellulose in examples 8-10
| Examples | Weight ratio of heparin to pineapple peel cellulose |
| 8 | 0.007:1 |
| 9 | 0.005:1 |
| 10 | 0.01:1 |
Comparative example 1
The preparation method of the facial mask is the same as in example 2 in other steps, and the difference from example 2 is that in step (2), wogonin/pineapple peel residue cellulose complex is replaced by wogonin.
Comparative example 2
The preparation method of the facial mask is the same as in example 2 in other steps, and the difference from example 2 is that in step (2), wogonin/pineapple peel residue cellulose compound is replaced by pineapple peel residue cellulose.
Comparative example 3
The preparation method of the facial mask is the same as in example 2 in other steps, and the difference is that in the step (2), no wogonin/pineapple peel residue cellulose compound is added.
Comparative example 4
The preparation method of the mask was the same as in example 2, except that erythritol was not added in step (2) as in example 2.
Comparative example 5
The preparation method of the facial mask is the same as in example 2 in other steps, and the difference is that in the step (2), no wogonin/pineapple peel residue cellulose compound and erythritol are added.
Test example 1
1. Determination of facial mask surface topography
Analysis was performed by using JSM-6700F-type field emission scanning electron microscope (JEOL Co., ltd.). And freeze-drying the test sample for 24 hours, and observing the surface structure of the mask under 5kV accelerating voltage after the surface of the sample is subjected to metal spraying and film plating by a sub-sputtering instrument.
Fig. 1 is an SEM image of the surface of the mask in example 2. As can be seen from fig. 1, in the mask of embodiment 2, a larger network structure exists, in which cellulose and other components contained therein are adhered to each other, so that the mesh closure degree is large, the air permeability of the mask is reduced, the density is increased, the evaporation of essence in the mask is prevented, the essence contained in each component enables the mask to better adhere to the skin, and excessive grease in the skin is absorbed in a large amount, so that the purposes of moisture retention and purification are achieved.
Test example 2
2. Determination of mask Water-holding Capacity
The wet film of a certain thickness was cut into a film of the same shape and dimensions 3cm x 3 cm. Boiling in water at 100deg.C for 1 hr, weighing and recording wet film weight at 10min, 30min and 60 min; after treatment, placing the wet film into a 60 ℃ oven for 6-10 hours to constant weight, weighing and recording the dry film weight, and then calculating the water holding multiplying power of the mask, wherein the calculation formula is as follows:
water holding capacity = wet film weight/dry film weight
Fig. 2 shows the water holding capacity of the mask. As can be seen from fig. 2, before water absorption, the water holding ratio of the mask in the embodiment 2 and the embodiment 8 is higher than 120, after water absorption for 30min and 60min, the water holding ratio of the mask in the embodiment 2 and the embodiment 8 is almost increased slowly and almost reaches saturation, at the moment, the water holding ratio of the mask is not lower than 190, and the water holding ratio of the mask in the embodiment 2 and the embodiment 8 is higher than that of the embodiment 2, which indicates that the pineapple peel residue cellulose is modified, and the wogonin/modified pineapple peel residue cellulose compound is used as a raw material of the mask, so that the water holding ratio of the mask is further improved; comparative example 2 and comparative examples 1-5, example 2 has a higher water holding capacity than comparative examples 1-5, which demonstrates that adding wogonin/pineapple peel residue cellulose complex and erythritol to the mask simultaneously increases the water holding capacity of the mask; the reason is probably that the wogonin/pineapple peel residue cellulose compound can form a larger network structure, so that the bitter Ding Chaduo phenol, the erythritol and the methyl p-hydroxybenzoate are fixed in the internal structure of the wogonin/pineapple peel residue cellulose compound by utilizing the double effects of physical adsorption or hydrogen bond coupling, and the purpose of water retention is achieved.
3. Determination of heat-resistant and cold-resistant stability of mask
Placing the mask at 40 ℃ and 0 ℃ for 15 days respectively, taking out the mask to be recovered to room temperature, and observing whether the mask has obvious difference from the mask before the test; "+" represents normal and "-" represents abnormal.
Table 4 results of qualitative measurement of heat stability and Cold resistance temperature of examples
Table 4 shows the results of the heat and cold stability tests of the mask. As can be seen from table 4, the heat and cold stability of examples 1 to 10 are normal, and the heat and cold stability of comparative example 2 and comparative examples 1 to 5 are better than those of comparative examples 1 to 5, which indicates that adding wogonin/pineapple peel residue cellulose complex and erythritol to the mask simultaneously improves the heat and cold stability of the mask.
4. Determination of mask moisture retention rate
Placing the mask sample in a drying oven with the temperature of 25 ℃, taking out the mask sample after placing for 8 hours, weighing the mask sample, recording data, and calculating the moisture retention rate of the mask, wherein the calculation formula is as follows:
B＝M 2 /M 1 ×100％
wherein B is the moisture retention rate,%; m is M 1 G, for placing the water content quality of the front mask; m is M 2 G, the water content of the rear mask is set.
Fig. 3 shows the moisture retention of the mask. As can be seen from fig. 3, the moisture retention of the mask in examples 1-7 is higher than 95%, the moisture retention of the mask in examples 8-10 is higher than 99%, and the moisture retention of comparative example 2 and example 8, example 8 is higher than example 2, which shows that the modification of the pineapple peel residue cellulose, the wogonin/modified pineapple peel residue cellulose compound is used as the raw material of the mask, and the compound is used as the component of the mask to interact with other components, so that the moisture retention of the mask is further improved; comparative example 2 and comparative examples 1-5, example 2 all had higher moisturizing rates than comparative examples 1-5, demonstrating that the addition of both wogonin/pineapple peel residue cellulose complex and erythritol to the mask increases the moisturizing rate of the mask; the reason is probably that the wogonin/pineapple peel residue cellulose compound can form a larger network structure, so that the bitter Ding Chaduo phenol, the erythritol and the methyl p-hydroxybenzoate are fixed in the internal structure of the wogonin/pineapple peel residue cellulose compound by utilizing the double effects of physical adsorption or hydrogen bond coupling, thereby achieving the purpose of moisturizing.
5. Determination of mask Oxidation resistance
DPPH 1.5mg was weighed out and the volume was fixed with 95% ethanol and a 50mL volumetric flask was used. Respectively weighing 2mL of each of the sample solution and DPPH solution in a test tube by using a micropipetteIn the above steps, shaking up and standing for 35min, and measuring absorbance A at 517nm with solvent as control s . Simultaneously testing the mixture of 2mL of the sample solution and 2mL of 95% ethanol as the solvent of the sample solution, and measuring absorbance A at 517nm by using an ultraviolet-visible spectrophotometer f . Determination of absorbance A at 517nm after mixing 2mL of 95% ethanol with 2mL of LDPPH solution 0 。
Clearance y= [1- (a) s -A f )/A 0 ]×100％
Fig. 4 shows DPPH removal rate of mask. As can be seen from fig. 4, the removal rate of the mask in examples 1-7 is higher than 92.5%, the removal rate of examples 8-10 is higher than 95%, and the removal rate of comparative examples 2 and 8, example 8 is higher than example 2, which shows that the modification of the pineapple peel residue cellulose, the wogonin/modified pineapple peel residue cellulose compound is used as the raw material of the mask, and the compound is used as the component of the mask, and interacts with other components, so that the DPPH removal rate of the mask is further improved, namely the oxidation resistance of the mask is improved; comparative example 2 and comparative examples 1-5, the clearance rate of example 2 is significantly higher than that of comparative examples 1-5, which demonstrates that adding wogonin/pineapple peel residue cellulose complex and erythritol to the mask simultaneously increases the DPPH clearance rate of the mask, i.e., oxidation resistance; the reason is probably that the components in the mask interact to prevent melanin from depositing and achieve the effect of antioxidation.
6. Determination of inhibition rate of mask tyrosinase
PBS (phosphate buffer) with pH=6.8, 1.0mg/mL of L-tyrosine solution and 0.1mg/mL of tyrosinase solution were prepared, respectively. Sample addition was performed according to the following ratios, wherein the test sample 1:2.0mL PBS+0.5mL tyrosinase solution+0.5 mL L-tyrosine solution; test sample 2:2.5mL PBS+0.5mL tyrosinase solution; test sample 3:0.5 mL sample solution+1.5 mL PBS+0.5mL tyrosinase solution+0.5 mL L-tyrosine solution; test sample 4:0.5mL sample solution+2.0 mL PBS+0.5mL tyrosinase solution. Mixing the test samples, mixing 1-4 test samples, placing in water bath at 37deg.C for 30min, immediately taking out, and measuring absorbance at 475nm (A 1 -A 4 ). The tyrosinase inhibition rate (I) of the mask was calculated as follows.
I＝[1-(A 3 -A 4 )/(A 1 -A 2 )]×100％
Wherein: a is that 1 -A 4 To test the absorbance values of samples 1-4 at 475 nm.
FIG. 5 shows tyrosinase inhibition rate of the mask. As can be seen from fig. 5, the tyrosinase inhibition rate of examples 1-7 is not lower than 92%, the tyrosinase inhibition rate of examples 8-10 is not lower than 95%, and the tyrosinase inhibition rate of comparative example 2 and example 8, example 8 is higher than example 2, which shows that the modification of pineapple peel residue cellulose, the scum-based/modified pineapple peel residue cellulose compound is used as the raw material of the mask, and the compound is used as the component of the mask to interact with other components, so that the tyrosinase inhibition rate of the mask is further improved; comparative example 2 and comparative examples 1 to 5, the tyrosinase inhibition rate of example 2 is higher than that of comparative examples 1 to 5, which shows that the addition of wogonin/pineapple peel residue cellulose complex and erythritol to the mask simultaneously increases the tyrosinase inhibition rate of the mask; the reason is probably that the interaction of the components in the mask has better inhibition effect on tyrosinase, prevents melanin from depositing and achieves the whitening effect.
7. Determination of mask safety
Skin irritation test, 24 hours before test, 8 healthy rats are selected, and the back and the spine of each rat are cut with 3.0cm multiplied by 3.0cm area of hair. 0.5mL of the membrane solution was applied to the sheared area on one side and Pi Yici a day as a control, and the residue was removed with warm water and continuously coated 14d. And (3) observation of test results: during the application, the reaction of the applied skin was observed 1h after each day of washing, and the skin was scored according to the cosmetic safety Specification (2015). Skin irritation intensity evaluation criteria: 0-0.4 is classified as non-irritating; 0.5-2.9 is classified as light-irritating; 3.0-5.9 are classified as medium irritation; 6.0-8.0 are classified as strongly irritating.
TABLE 5 results of skin irritation test of mask on rats
Table 5 shows the results of the skin irritation test of the mask to rats. As can be seen from Table 5, examples 1 to 10 showed no irritation to the skin after the application of the masks 1d and 14d, which indicated that the masks did not contain substances irritating to the skin, and were superior in safety.
Conventional operations in the operation steps of the present invention are well known to those skilled in the art, and are not described herein.
The above embodiments are merely for illustrating the present invention and not for limiting the same, and various changes and modifications may be made by one of ordinary skill in the art without departing from the spirit and scope of the invention. Therefore, all equivalent technical solutions also fall within the scope of the invention, the scope of which is defined by the claims.
Claims (9)
1. A method for preparing a facial mask, which comprises the following steps: mixing wogonin/pineapple peel residue cellulose compound, bitter Ding Chaduo phenol, erythritol and methyl parahydroxybenzoate, pouring into a mold, cleaning, autoclaving, and freezing to obtain facial mask;
15-30 parts of wogonin/pineapple peel residue cellulose compound, 5-9 parts of bitter Ding Chaduo phenol, 7-12 parts of erythritol and 1-4 parts of methyl parahydroxybenzoate;
the preparation method of the wogonin/pineapple peel residue cellulose compound comprises the following steps:
pretreating pineapple peel residues to obtain pineapple peel residue crude fibers A;
step-by-step extraction of the pineapple peel residue crude fiber A by distilled water and sodium hydroxide to obtain pineapple peel residue fiber B;
performing heat treatment on the pineapple peel residue fiber B through sodium chlorite solution, washing and drying to obtain pineapple peel residue fiber C;
bleaching the pineapple peel residue fiber C by alkaline hydrogen peroxide at 65-75 ℃ to obtain pineapple peel residue cellulose;
dissolving the pineapple peel residue cellulose in acetic acid solution, then adding wogonin, stirring uniformly, performing ultrasonic degassing, and drying to obtain a wogonin/pineapple peel residue cellulose compound.
2. The method for preparing the facial mask according to claim 1, wherein the method comprises the following steps: the high-pressure sterilization temperature is 105-115 ℃ and the sterilization time is 25-35 min.
3. The method for preparing the facial mask according to claim 1, wherein the method comprises the following steps: the freezing conditions are as follows: freezing at-25 to-15 ℃ for 20-22 h.
4. The method for preparing the facial mask according to claim 1, wherein the method comprises the following steps: in the preparation step of the wogonin/pineapple peel residue cellulose compound, the solid-liquid density ratio of step extraction is 1:15-20, the treatment temperature is 60-70 ℃, and the treatment time is 1.5-2.5 h.
5. The method for preparing the facial mask according to claim 1, wherein the method comprises the following steps: in the preparation step of the wogonin/pineapple peel residue cellulose compound, the pH value of the sodium chlorite solution is regulated to 3.85-4.05 by hydrochloric acid.
6. The method for preparing the facial mask according to claim 1, wherein the method comprises the following steps: in the preparation step of the wogonin/pineapple peel residue cellulose compound, the heat treatment temperature is 65-75 ℃ and the time is 1-1.5 h.
7. The method for preparing the facial mask according to claim 1, wherein the method comprises the following steps: in the preparation step of the wogonin/pineapple peel residue cellulose compound, the pineapple peel residue cellulose is 1-6 parts by weight, and the wogonin is 0.02-0.08 part by weight.
8. The method for preparing the facial mask according to claim 1, wherein the method comprises the following steps: the modified pineapple peel residue cellulose is obtained by grafting modification of the pineapple peel residue cellulose by heparin, and then the modified pineapple peel residue cellulose reacts with wogonin to obtain a wogonin/modified pineapple peel residue cellulose compound.
9. The mask of claim 1, wherein the tyrosinase inhibition rate is not less than 92%.
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