CN112237240A - Preparation technology of slow-release enteric microcapsule plant essential oil - Google Patents
Preparation technology of slow-release enteric microcapsule plant essential oil Download PDFInfo
- Publication number
- CN112237240A CN112237240A CN201910640363.4A CN201910640363A CN112237240A CN 112237240 A CN112237240 A CN 112237240A CN 201910640363 A CN201910640363 A CN 201910640363A CN 112237240 A CN112237240 A CN 112237240A
- Authority
- CN
- China
- Prior art keywords
- essential oil
- release
- slow
- plant essential
- microcapsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000341 volatile oil Substances 0.000 title claims abstract description 95
- 239000003094 microcapsule Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000011248 coating agent Substances 0.000 claims abstract description 35
- 238000000576 coating method Methods 0.000 claims abstract description 35
- 239000006187 pill Substances 0.000 claims abstract description 18
- 239000002775 capsule Substances 0.000 claims abstract description 17
- 239000004925 Acrylic resin Substances 0.000 claims abstract description 16
- 229920000178 Acrylic resin Polymers 0.000 claims abstract description 16
- 239000011162 core material Substances 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 15
- 238000002156 mixing Methods 0.000 claims abstract description 15
- 238000013268 sustained release Methods 0.000 claims abstract description 15
- 239000012730 sustained-release form Substances 0.000 claims abstract description 15
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims abstract description 11
- 239000002131 composite material Substances 0.000 claims abstract description 10
- 241000196324 Embryophyta Species 0.000 claims description 40
- ROWKJAVDOGWPAT-UHFFFAOYSA-N Acetoin Chemical compound CC(O)C(C)=O ROWKJAVDOGWPAT-UHFFFAOYSA-N 0.000 claims description 16
- 239000000243 solution Substances 0.000 claims description 16
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 239000002994 raw material Substances 0.000 claims description 13
- 230000002195 synergetic effect Effects 0.000 claims description 13
- 239000007864 aqueous solution Substances 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000011259 mixed solution Substances 0.000 claims description 10
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 229940117916 cinnamic aldehyde Drugs 0.000 claims description 9
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims description 9
- 241000190633 Cordyceps Species 0.000 claims description 8
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 claims description 8
- GFAZHVHNLUBROE-UHFFFAOYSA-N hydroxymethyl propionaldehyde Natural products CCC(=O)CO GFAZHVHNLUBROE-UHFFFAOYSA-N 0.000 claims description 8
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 8
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims description 8
- 235000012141 vanillin Nutrition 0.000 claims description 8
- 239000000834 fixative Substances 0.000 claims description 7
- 235000001510 limonene Nutrition 0.000 claims description 7
- 229940087305 limonene Drugs 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims description 6
- 229920001661 Chitosan Polymers 0.000 claims description 4
- 235000010489 acacia gum Nutrition 0.000 claims description 4
- 229960002903 benzyl benzoate Drugs 0.000 claims description 4
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims description 3
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims description 3
- 235000005979 Citrus limon Nutrition 0.000 claims description 3
- 244000131522 Citrus pyriformis Species 0.000 claims description 3
- 239000005770 Eugenol Substances 0.000 claims description 3
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims description 3
- 239000002199 base oil Substances 0.000 claims description 3
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 3
- 238000005354 coacervation Methods 0.000 claims description 3
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- 229960002217 eugenol Drugs 0.000 claims description 3
- 239000003205 fragrance Substances 0.000 claims description 3
- 239000005457 ice water Substances 0.000 claims description 3
- 239000010661 oregano oil Substances 0.000 claims description 3
- 229940111617 oregano oil Drugs 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 239000010678 thyme oil Substances 0.000 claims description 3
- 241000675108 Citrus tangerina Species 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 10
- 230000000968 intestinal effect Effects 0.000 abstract description 4
- 210000002784 stomach Anatomy 0.000 abstract description 4
- 230000003385 bacteriostatic effect Effects 0.000 abstract description 3
- 238000013270 controlled release Methods 0.000 abstract description 2
- 210000004051 gastric juice Anatomy 0.000 abstract description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract description 2
- 239000008158 vegetable oil Substances 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 5
- 238000005538 encapsulation Methods 0.000 description 3
- 235000019629 palatability Nutrition 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000006065 biodegradation reaction Methods 0.000 description 2
- 229930007927 cymene Natural products 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 1
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 1
- 235000007746 carvacrol Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000000816 effect on animals Effects 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000003629 gastrointestinal hormone Substances 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 229940117960 vanillin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Husbandry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of plant essential oil preparation, and discloses a preparation technology of slow-release enteric microcapsule plant essential oil, wherein the plant essential oil adopts a structural form of an essential oil microcapsule, and the essential oil microcapsule is prepared in a double-coating mode and specifically comprises an inner coating and an outer coating; mixing acrylic resin II and acrylic resin III to form an inner coating material, and coating a plant essential oil core material to form an enteric slow-release pill; taking chitosan-Arabic gum as a composite capsule wall material as an outer capsule, and coating the composite capsule wall material outside the enteric sustained-release pill to form an essential oil microcapsule; in the double-coated essential oil microcapsule, the inner coating material is dissolved in intestinal solution but not in gastric juice, so that the microcapsule smoothly passes through the stomach to reach the intestinal tract, and stable slow release of the vegetable oil is carried out in the intestinal tract, thereby forming a good bacteriostatic effect on the intestinal tract; the outer capsule material has good thermal stability, thereby improving the controlled release and sustained release performance of the essential oil microcapsule.
Description
Technical Field
The invention belongs to the technical field of plant essential oil preparation, and particularly relates to a preparation technology of slow-release enteric microcapsule plant essential oil.
Background
The active ingredients in the natural plant essential oil are mostly phenol, aldehyde, terpenes and other substances, and the natural plant essential oil has the characteristics of poor stability (low melting point, easy volatilization, easy oxidation), strong irritation, peculiar smell and difficult storage; and as the concentration of the natural plant essential oil is higher, the pungent smell is stronger, so that the palatability of the feed is greatly influenced, and the feed intake is reduced; in addition, untreated essential oil is rapidly absorbed at the front ends of the stomach and the intestinal tract and cannot effectively reach the rear intestine to achieve the effects of bacteriostasis and the like, and particularly, carvacrol, thymol and other substances are easy to combine with albumin to generate an inactivation phenomenon;
the slow release technology is a technology for coating solid or liquid or gas by adopting natural, semisynthetic or synthetic polymer film-forming materials to form micro particles, and has the characteristics of slow release, taste masking, solidification of liquid components, enhancement of the stress resistance of the components, stomach passing (dissolution reduction), intestinal positioning release and good fluidity;
in conclusion, the animal edible essential oil with strong stability, good palatability and long positioning and bacteriostasis time can be prepared based on the slow release technology.
Disclosure of Invention
The invention aims to provide a preparation technology of slow-release enteric microcapsule plant essential oil, and aims to solve the problems that the existing natural plant essential oil is poor in stability and palatability and cannot be accurately positioned for bacteriostasis.
In order to achieve the purpose, the invention provides the following technical scheme:
1. the slow-release enteric microcapsule plant essential oil is in the structural form of an essential oil microcapsule, and the essential oil microcapsule is manufactured in a double-coating mode and specifically comprises an inner coating and an outer coating;
specifically, the method comprises the following steps: mixing acrylic resin II and acrylic resin III to form an inner coating material, and coating a plant essential oil core material to form an enteric slow-release pill; the chitosan-Arabic gum is taken as a composite capsule material to be an outer capsule, and the enteric sustained-release pill is coated with the chitosan-Arabic gum to form the essential oil microcapsule.
Preferably, the plant essential oil core material consists of an essential oil fixative, a synergistic raw material, a phagostimulant and plant base oil, wherein the synergistic raw material not only can generate a synergistic effect with the main components of the essential oil, but also can form an essential oil phagostimulant with the phagostimulant.
Specifically, the method comprises the following steps: the essential oil fixative mainly comprises vanillin, benzyl alcohol and benzyl benzoate; the synergistic raw materials mainly comprise p-cymene, limonene and pinene; the phagostimulant mainly comprises cordyceps peptide, tangerine peel oil, acetoin and cinnamaldehyde; it is worth mentioning that the cinnamaldehyde has the bacteriostatic effect and the food calling effect.
Preferably, the plant essential oil core material and the inner coating or the outer coating are coated by adopting a saturated aqueous solution method or a complex coacervation method.
2. The preparation technology of the slow-release enteric microcapsule plant essential oil comprises the following preparation steps:
a. mixing oregano oil, thyme oil, eugenol, vanillin, limonene, lemon essential oil, cinnamaldehyde, cordyceps peptide and acetoin to form a compound essential oil core material;
b. respectively preparing acrylic resin II and acrylic resin III aqueous solutions, mixing, placing in a constant-temperature water bath at 50 ℃, and uniformly stirring;
c. mixing the compound essential oil core material prepared in the step a into the solution prepared in the step b, carrying out high-speed homogenizing and emulsifying, simultaneously adding 10% acetic acid solution into the mixed solution, and adjusting the pH value to 3.8-4.0;
d. taking the mixed solution prepared in the step c out of the water bath environment, continuously stirring, and naturally cooling to 32-35 ℃;
e. d, putting the cooled mixed solution in the step d into an ice water environment, carrying out water bath cooling to reduce the temperature to below 10 ℃, simultaneously adding a 20% sodium hydroxide solution into the mixed solution, adjusting the pH value to 8-9, and continuously stirring to separate out the enteric-coated sustained-release pills; specifically, the grain diameter of the precipitated enteric-coated sustained-release pill is less than 2.5 mm;
f. respectively preparing 0.5 percent aqueous solution and 4 percent aqueous solution of chitosan and Arabic gum, and uniformly stirring in a constant-temperature water bath at 50-55 ℃;
g. taking the enteric-coated sustained-release pill and the solution prepared in the step f as raw materials, and repeating the operations of the step c, the step d and the step e to separate out the essential oil microcapsules;
compared with the prior art, the invention has the following beneficial effects:
(1) the essential oil microcapsule is prepared by adopting a double coating mode, wherein the inner coating is formed by mixing acrylic resin II and acrylic resin III and is dissolved in an intestinal solution, so that the microcapsule smoothly passes through the stomach to reach the intestinal tract, and the vegetable oil is stably released in the intestinal tract, thereby forming a good antibacterial effect on the intestinal tract; in addition, the outer capsule adopts chitosan and Arabic gum as composite capsule walls, and the encapsulation is stable, so that the essential oil microcapsule has good controlled release and slow release effects, and meanwhile, the composite capsule walls are non-toxic and harmless and have good biodegradation performance.
(2) The inner coating and the composite capsule wall have good slow release performance, the plant essential oil is slowly released in intestinal tracts, and the positioning bacteriostasis time is prolonged, so that the plant essential oil prepared by the invention has a more lasting effect.
(3) In the invention, the plant essential oil is also added with the essential oil fixative, thereby effectively delaying the release of the aroma of the essential oil and the volatilization of the essential oil, further improving the stability of the essential oil and being beneficial to the storage of the essential oil; meanwhile, the volatilization speed of the essential oil is reduced, and a certain slow release purpose is achieved.
(4) In order to solve the problem that the plant essential oil is poor in using taste, a certain essential oil phagostimulant is added, and the essential oil phagostimulant mainly comprises a synergistic raw material formed by cymene, limonene and pinene and a phagostimulant formed by cordyceps peptide, acetoin and cinnamaldehyde, so that the odor of the plant essential oil can be effectively improved, and the feeding is promoted.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
1. The invention provides a slow-release enteric microcapsule plant essential oil which adopts the structural form of an essential oil microcapsule, and the corresponding essential oil microcapsule is manufactured in a double-coating mode and specifically comprises an inner coating and an outer coating;
specifically, the method comprises the following steps: mixing acrylic resin II and acrylic resin III to form an inner coating material, and coating a plant essential oil core material to form an enteric slow-release pill: the formed inner coating material is difficult to dissolve in gastric juice, but can form a dissolution rate of 75-84.5% in intestinal solution, so that the plant essential oil coated inside the inner coating can be effectively released in the intestinal tract, and a good bacteriostatic action is formed on the intestinal tract.
Taking chitosan-Arabic gum as a composite capsule material as an outer capsule, and coating the composite capsule material outside the enteric sustained-release pill to form an essential oil microcapsule: the formed essential oil microcapsules have the encapsulation rate of 62-65%, the encapsulation effect is stable, and the composite capsule wall material formed by the chitosan-Arabic gum also has good biodegradation performance.
Preferably, the plant essential oil core material consists of an essential oil fixative, a synergistic raw material, a phagostimulant and plant base oil, wherein the synergistic raw material and the phagostimulant are matched to form an essential oil phagostimulant component;
further: (1) the fixative mainly comprises vanillin, benzyl benzoate and benzyl alcohol: the vanillin has the function of delaying the fragrance release of the essential oil, and the higher the vanillin amount is, the longer the fragrance retention time of the essential oil is; the benzyl benzoate has better stability, and achieves the purpose of slow release while reducing the volatilization of effective components and increasing the storage time of essential oil;
(2) the synergistic raw materials mainly comprise p-cymene, limonene and pinene: wherein, cymene, limonene, pinene and the like are auxiliary components of various essential oils and have synergistic effect on the main components of the essential oils;
(3) the phagostimulant mainly comprises cordyceps peptide, acetoin and cinnamaldehyde: wherein the Cordyceps peptide has effects of tranquilizing, relieving pain, inducing sleep, promoting ingestion, prolonging gastrointestinal peristalsis, and stimulating gastrointestinal hormone release; acetoin is one of the components in natural cream and has strong food calling effect on animals; the cinnamaldehyde has obvious antibacterial effect and can promote animal feeding.
Preferably, the plant essential oil core material and the inner coating or the outer coating are coated by adopting a saturated aqueous solution method or a complex coacervation method.
2. Aiming at the plant essential oil and the essential oil microcapsule, the preparation technology comprises the following preparation steps:
a. mixing oregano oil, thyme oil, eugenol, vanillin, lemon essential oil, cinnamaldehyde, cordyceps peptide and acetoin to form a compound essential oil core material;
b. respectively preparing acrylic resin II and acrylic resin III aqueous solutions, mixing, placing in a constant-temperature water bath at 50 ℃, and uniformly stirring;
c. mixing the compound essential oil core material prepared in the step a into the solution prepared in the step b, carrying out high-speed homogenizing and emulsifying, and simultaneously adjusting the pH value to 3.8-4.0;
specifically, the method comprises the following steps: in the process of adjusting the pH value, a 10% acetic acid solution is added into the mixed solution for adjustment, and meanwhile, the uniformity of mixing among the solutions is required to be ensured;
d. taking the mixed solution prepared in the step c out of the water bath environment, continuously stirring, and naturally cooling to 32-35 ℃;
e. d, putting the cooled mixed solution in the step d into an ice water environment, carrying out water bath cooling to reduce the temperature to below 10 ℃, simultaneously adjusting the pH value to 8-9, and continuously stirring to separate out the enteric-coated sustained-release pill;
specifically, the method comprises the following steps: in the process of adjusting the pH value, a 20% sodium hydroxide solution is added into the mixed solution for adjustment;
further: the grain diameter of the precipitated enteric-coated sustained-release pill is less than 2.5mm, so that the enteric-coated sustained-release pill can be stably coated in the outer capsule;
f. respectively preparing 0.5 percent aqueous solution and 4 percent aqueous solution of chitosan and Arabic gum, and uniformly stirring in a constant-temperature water bath at 50-55 ℃;
g. taking the enteric-coated sustained-release pill and the solution prepared in the step f as raw materials, and repeating the operations of the step c, the step d and the step e to separate out the essential oil microcapsules;
although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. The slow-release enteric microcapsule plant essential oil is characterized in that: the plant essential oil adopts the structural form of essential oil microcapsules, and the essential oil microcapsules are manufactured in a double-coating mode and specifically comprise an inner coating and an outer coating;
mixing acrylic resin II and acrylic resin III to form an inner coating material, and coating a plant essential oil core material to form an enteric slow-release pill;
the chitosan-Arabic gum is taken as a composite capsule material to be an outer capsule, and the enteric sustained-release pill is coated with the chitosan-Arabic gum to form the essential oil microcapsule.
2. The slow-release enteric microcapsule plant essential oil according to claim 1, characterized in that: the plant essential oil core material consists of plant base oil, a fragrance fixative, a synergistic raw material and a phagostimulant; the synergistic raw materials not only can generate synergistic effect with the essential oil main components, but also can form the essential oil phagostimulant components together with the phagostimulant.
3. The slow-release enteric microcapsule plant essential oil according to claim 2, characterized in that: the fixative mainly comprises vanillin, benzyl benzoate and benzyl alcohol.
4. The slow-release enteric microcapsule plant essential oil according to claim 2, characterized in that: the synergistic raw materials mainly comprise p-cymene, limonene and pinene.
5. The slow-release enteric microcapsule plant essential oil according to claim 2, characterized in that: the phagostimulant mainly comprises cordyceps peptide, tangerine peel oil, acetoin and cinnamaldehyde.
6. The slow-release enteric microcapsule plant essential oil according to claim 1, characterized in that: the plant essential oil core material and the inner coating or the outer coating are coated by adopting a saturated aqueous solution method or a complex coacervation method.
7. The technology for preparing the slow-release enteric microcapsule plant essential oil according to any claim, characterized by comprising the following preparation steps:
a. mixing oregano oil, thyme oil, eugenol, vanillin, lemon essential oil, limonene, cinnamaldehyde, cordyceps peptide and acetoin to form a compound essential oil core material;
b. respectively preparing acrylic resin II and acrylic resin III aqueous solutions, mixing, placing in a constant-temperature water bath at 50 ℃, and uniformly stirring;
c. mixing the compound essential oil core material prepared in the step a into the solution prepared in the step b, carrying out high-speed homogenizing and emulsifying, and simultaneously adjusting the pH value to 3.8-4.0;
d. taking the mixed solution prepared in the step c out of the water bath environment, continuously stirring, and naturally cooling to 32-35 ℃;
e. d, putting the cooled mixed solution in the step d into an ice water environment, carrying out water bath cooling to reduce the temperature to below 10 ℃, simultaneously adjusting the pH value to 8-9, and continuously stirring to separate out the enteric-coated sustained-release pill;
f. respectively preparing 0.5 percent aqueous solution and 4 percent aqueous solution of chitosan and Arabic gum, and uniformly stirring in a constant-temperature water bath at 50-55 ℃;
g. taking the enteric-coated sustained-release pill and the solution prepared in the step f as raw materials, and repeating the operations of the step c, the step d and the step e to realize the precipitation of the essential oil microcapsules.
8. The technology for preparing the slow-release enteric microcapsule plant essential oil according to claim 7, characterized in that: the pH value adjustment in the step c adopts a mode of adding 10% acetic acid solution; and e, adjusting the pH value in the step e by adding 20% sodium hydroxide solution.
9. The technology for preparing the slow-release enteric microcapsule plant essential oil according to claim 7, characterized in that: and e, the grain diameter of the enteric-coated sustained-release pill precipitated in the step e is less than 2.5 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910640363.4A CN112237240A (en) | 2019-07-16 | 2019-07-16 | Preparation technology of slow-release enteric microcapsule plant essential oil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910640363.4A CN112237240A (en) | 2019-07-16 | 2019-07-16 | Preparation technology of slow-release enteric microcapsule plant essential oil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112237240A true CN112237240A (en) | 2021-01-19 |
Family
ID=74167042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910640363.4A Pending CN112237240A (en) | 2019-07-16 | 2019-07-16 | Preparation technology of slow-release enteric microcapsule plant essential oil |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112237240A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004006896A1 (en) * | 2002-07-16 | 2004-01-22 | Warner-Lambert Company Llc | Oral care capsules |
| CN101269051A (en) * | 2008-05-08 | 2008-09-24 | 武汉工业学院 | Rumen-passed choline chloride microcapsules and its preparation process |
| CN102511909A (en) * | 2012-01-07 | 2012-06-27 | 中国海洋大学 | Microcapsule |
| CN103752236A (en) * | 2014-01-09 | 2014-04-30 | 陕西科技大学 | Preparation method of double-layer wrapped essence micro-capsule |
| CN104353401A (en) * | 2014-10-24 | 2015-02-18 | 苏州香满庭植物科技有限公司 | Complex coacervation multicore plant essential oil slow-release microcapsule as well as preparation method and application thereof |
| CN104705533A (en) * | 2015-04-14 | 2015-06-17 | 上海美农生物科技股份有限公司 | High-stability pig plant essential oil additive as well as preparation method and application thereof |
| WO2017175225A1 (en) * | 2016-04-06 | 2017-10-12 | Botanocap Ltd. | Spoilage retardant multilayer materials containing food safe adhesives |
| CN107773554A (en) * | 2017-09-07 | 2018-03-09 | 华南农业大学 | A kind of ivermectin slow-releasing microcapsule and its preparation method and application |
-
2019
- 2019-07-16 CN CN201910640363.4A patent/CN112237240A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004006896A1 (en) * | 2002-07-16 | 2004-01-22 | Warner-Lambert Company Llc | Oral care capsules |
| CN101269051A (en) * | 2008-05-08 | 2008-09-24 | 武汉工业学院 | Rumen-passed choline chloride microcapsules and its preparation process |
| CN102511909A (en) * | 2012-01-07 | 2012-06-27 | 中国海洋大学 | Microcapsule |
| CN103752236A (en) * | 2014-01-09 | 2014-04-30 | 陕西科技大学 | Preparation method of double-layer wrapped essence micro-capsule |
| CN104353401A (en) * | 2014-10-24 | 2015-02-18 | 苏州香满庭植物科技有限公司 | Complex coacervation multicore plant essential oil slow-release microcapsule as well as preparation method and application thereof |
| CN104705533A (en) * | 2015-04-14 | 2015-06-17 | 上海美农生物科技股份有限公司 | High-stability pig plant essential oil additive as well as preparation method and application thereof |
| WO2017175225A1 (en) * | 2016-04-06 | 2017-10-12 | Botanocap Ltd. | Spoilage retardant multilayer materials containing food safe adhesives |
| CN107773554A (en) * | 2017-09-07 | 2018-03-09 | 华南农业大学 | A kind of ivermectin slow-releasing microcapsule and its preparation method and application |
Non-Patent Citations (1)
| Title |
|---|
| 唐延甜: "肠溶聚丙烯酸树脂体外游离膜的考察", 《西北药学杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0287488B1 (en) | Medicament, dietary product and hygienic product in the form of a powdery composition obtained by adsorption of the active agents on a rapidly dissolving sugar, and process for the preparation of this composition | |
| EP0022046B1 (en) | Drug composition based on plants and process for its preparation | |
| FR2935084A1 (en) | ADDITIVE FOR ANIMAL FEED AND METHOD FOR PREPARING THE SAME | |
| EP0620731A1 (en) | PHARMACEUTICAL PREPARATION IN THE FORM OF A SHOWER AND / OR DECOMPOSITION TABLET OR INSTANT GRANULES, AND METHOD FOR THE PRODUCTION THEREOF. | |
| CN1151679A (en) | Beverage composition comprising green tea solids, electrolytes and carbohydrates to provide improved cellular hydration and drinkability | |
| CN102429141A (en) | Preparation method and application of propolis microcapsules | |
| CH686923A5 (en) | A composition for improving the digestibility of feed for ruminant animals. | |
| LU83507A1 (en) | CONTROLLED RELEASE OF TRACE ELEMENTS | |
| CN104922073A (en) | Soluble florfenicol powder and preparation method thereof | |
| WO2023197579A1 (en) | Sustained-release vitamin c pellet and method for preparing same | |
| FR2935870A1 (en) | BI-AROMATISE ADDITIVE FOR ANIMAL FEEDING AND METHOD FOR PREPARING THE SAME | |
| CN105581198A (en) | Formula and production process of sober-up vitamin nutrient-reinforcing drink | |
| CN105454685A (en) | Application of tannin micro-capsule in preparation of pig feed additive | |
| CN112237240A (en) | Preparation technology of slow-release enteric microcapsule plant essential oil | |
| CN107412185A (en) | A kind of dog containing food calling composition, cat soft capsule | |
| CN106562116A (en) | Breeding fish feed additive composition and use thereof | |
| CA2335713C (en) | Oral dosage form | |
| CN105165757A (en) | Effervescent tablet type fishing bait and preparation method thereof | |
| CN101612174A (en) | Application of the total extract of mangosteen husk in the preparation of anti-inflammatory and analgesic drugs | |
| CN108935549A (en) | A kind of plant source microcapsules suspension formulation and preparation method thereof | |
| CN109043155A (en) | A kind of preparation method of the meat sheep feed additive instead of antibiotic | |
| CN116327739A (en) | A kind of DHA algae oil bird's nest acid mouth film dissolving agent and preparation method thereof | |
| FR2720944A1 (en) | Therapeutic or dietary composition in the form of a medicated gel for administration to pets. | |
| CA3161557A1 (en) | Choline bolus compositions for ruminants | |
| CN116349787B (en) | Milk cow postpartum fast and long-acting calcium supplementing preparation and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20210119 |